Alan Hendrie Beggs, PH.D.
|Title||Sir Edwin and Lady Manton Professor of Pediatrics|
|Institution||Children's Hospital Boston|
Genetics, CLSB 15026
300 Longwood Ave
Boston MA 02115
Available: 08/01/12, Expires: 08/31/14
Conduct laboratory reseach on the genetics and molecular pathophysiology of human congenital myopathies and muscular dystrophies. We are a molecular biology lab and do a wide variety of techniques aimed at understanding the molecular basis of normal muscle function and its dysfunction in various neuromuscular disease states. Project will depend on individual student; please see website for more information.
Available: 07/01/11, Expires: 06/30/16
Medical and dental students are invited to participate in any one of multiple ongoing labroratory-based research projects in the Beggs laboratory (http://www.childrenshospital.org/research/beggs/). Projects may be for only one summer, or extend beyond that depending on the student's wishes and schedule. The laboratory uses the tools of molecular genetics, genomics, cell biology and biochemistry to study the genetic and molecular basis for human neuromuscular diseases with a focus on primary disorders of skeletal muscle such as congenital myopathies and muscular dystrophies. Research studies encompass genetic and biochemical testing of human clinical materiel, and creation and analysis, as well as preclinical therapeutic trials, of murine, zebrafish, and cell-based models of these conditions. Students are encouraged to develop their own independent sub-projects related to ongoing studies in the lab, and will have the opportunity to work directly with postdoctoral fellows, technicians and other students, but will retain personal responsibility for their own work with the hope that it will result in authorship on a scientific publication(s).
Characterizing Novel Gene Mutations in Congenital Myopathies: tropomyosin 3 screen in patients with CFTD
Summer, 06/11/07 - 08/10/07
Nebulin Mutations and Their Corresponding Phenotype in Nemaline Myopathy
Summer, 06/19/06 - 12/22/06
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