Marcia C. Haigis, Ph.D.
|Title||Associate Professor of Cell Biology|
|Institution||Harvard Medical School|
|Address||Harvard Medical School|
Cell Biology, Seeley Mudd Bldg 329
250 Longwood Ave
Boston MA 02115
Available: 10/01/12, Expires: 09/27/14
The Haigis laboratory is interested in understanding the links between mitochondrial dysfunction and cancer onset and progression. Mitochondria are dynamic organelles that provide cells with energy and are also a major site for reactive oxygen species production and stress response. Not surprisingly, mitochondrial dysfunction and aberrant metabolism have been implicated in metabolic diseases and several types of cancer.
Mammals have seven homologs of the protein deacetylase SIR2, three of which are found in mitochondria. Recent studies have shown that sirtuins are key regulators of mitochondrial function and energy production. Our lab is focused on understanding the links between sirtuins and tumor cell metabolism. The main goals of this research project will be: 1) to identify novel substrates of mitochondrial sirtuins and 2) to determine how aberrant sirtuin function may promote tumor cell metabolism. To accomplish these goals, our research integrates biochemistry, proteomics, cell biology and mouse genetics.
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