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Brendan D. Price, Ph.D.

TitleAssociate Professor of Radiation Oncology
InstitutionDana-Farber Cancer Institute
DepartmentRadiation Oncology
AddressDana-Farber Cancer Institute
J516
450 Brookline Ave
Boston MA 02215
Phone617/632-4946
Fax617/632-4599

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Park E, Kim H, Kim JM, Primack B, Vidal-Cardenas S, Xu Y, Price BD, Mills AA, D'Andrea AD. FANCD2 Activates Transcription of TAp63 and Suppresses Tumorigenesis. Mol Cell. 2013 Jun 27; 50(6):908-18.
    View in: PubMed
  2. Price BD, D'Andrea AD. Chromatin remodeling at DNA double-strand breaks. Cell. 2013 Mar 14; 152(6):1344-54.
    View in: PubMed
  3. Berbeco RI, Korideck H, Ngwa W, Kumar R, Patel J, Sridhar S, Johnson S, Price BD, Kimmelman A, Makrigiorgos GM. DNA Damage Enhancement from Gold Nanoparticles for Clinical MV Photon Beams. Radiat Res. 2012 Dec; 178(6):604-8.
    View in: PubMed
  4. Xu Y, Ayrapetov MK, Xu C, Gursoy-Yuzugullu O, Hu Y, Price BD. Histone H2A.Z Controls a Critical Chromatin Remodeling Step Required for DNA Double-Strand Break Repair. Mol Cell. 2012 Dec 14; 48(5):723-33.
    View in: PubMed
  5. Xu C, Xu Y, Gursoy-Yuzugullu O, Price BD. The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1. FEBS Lett. 2012 Nov 2; 586(21):3920-5.
    View in: PubMed
  6. Xu Y, Xu C, Price BD. Mechanistic links between ATM and histone methylation codes during DNA repair. Prog Mol Biol Transl Sci. 2012; 110:263-88.
    View in: PubMed
  7. Xu Y, Parmar K, Du F, Price BD, Sun Y. The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase. Int J Biochem Mol Biol. 2011; 2(4):295-302.
    View in: PubMed
  8. Ayrapetov MK, Xu C, Sun Y, Zhu K, Parmar K, D'Andrea AD, Price BD. Activation of Hif1a by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. PLoS One. 2011; 6(10):e26064.
    View in: PubMed
  9. Xu Y, Price BD. Chromatin dynamics and the repair of DNA double strand breaks. Cell Cycle. 2011 Jan 15; 10(2):261-7.
    View in: PubMed
  10. Xu Y, Sun Y, Jiang X, Ayrapetov MK, Moskwa P, Yang S, Weinstock DM, Price BD. The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol. 2010 Oct 4; 191(1):31-43.
    View in: PubMed
  11. Lin CI, Whang EE, Donner DB, Du J, Lorch J, He F, Jiang X, Price BD, Moore FD, Ruan DT. Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer. Mol Cancer Res. 2010 Sep; 8(9):1217-26.
    View in: PubMed
  12. Jiang X, Xu Y, Price BD. Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway. FEBS Lett. 2010 Jul 2; 584(13):2926-30.
    View in: PubMed
  13. Sun Y, Jiang X, Price BD. Tip60: connecting chromatin to DNA damage signaling. Cell Cycle. 2010 Mar 1; 9(5):930-6.
    View in: PubMed
  14. Lin CI, Whang EE, Abramson MA, Jiang X, Price BD, Donner DB, Moore FD, Ruan DT. Autophagy: a new target for advanced papillary thyroid cancer therapy. Surgery. 2009 Dec; 146(6):1208-14.
    View in: PubMed
  15. Kim K, Pollard JM, Norris AJ, McDonald JT, Sun Y, Micewicz E, Pettijohn K, Damoiseaux R, Iwamoto KS, Sayre JW, Price BD, Gatti RA, McBride WH. High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones. Clin Cancer Res. 2009 Dec 1; 15(23):7238-45.
    View in: PubMed
  16. Lin CI, Whang EE, Donner DB, Jiang X, Price BD, Carothers AM, Delaine T, Leffler H, Nilsson UJ, Nose V, Moore FD, Ruan DT. Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer. Mol Cancer Res. 2009 Oct; 7(10):1655-62.
    View in: PubMed
  17. Sun Y, Jiang X, Xu Y, Ayrapetov MK, Moreau LA, Whetstine JR, Price BD. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat Cell Biol. 2009 Nov; 11(11):1376-82.
    View in: PubMed
  18. Sun Y, Xu Y, Roy K, Price BD. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol Cell Biol. 2007 Dec; 27(24):8502-9.
    View in: PubMed
  19. Fernandes ND, Sun Y, Price BD. Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. J Biol Chem. 2007 Jun 1; 282(22):16577-84.
    View in: PubMed
  20. Sun Y, Jiang X, Chen S, Price BD. Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Lett. 2006 Aug 7; 580(18):4353-6.
    View in: PubMed
  21. Roy K, Wang L, Makrigiorgos GM, Price BD. Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity. Biochem Biophys Res Commun. 2006 Jun 9; 344(3):821-6.
    View in: PubMed
  22. Jiang X, Sun Y, Chen S, Roy K, Price BD. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. J Biol Chem. 2006 Jun 9; 281(23):15741-6.
    View in: PubMed
  23. Sun Y, Jiang X, Chen S, Fernandes N, Price BD. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13182-7.
    View in: PubMed
  24. Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD. DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. J Biol Chem. 2005 Apr 15; 280(15):15158-64.
    View in: PubMed
  25. Wang G, Brennan C, Rook M, Wolfe JL, Leo C, Chin L, Pan H, Liu WH, Price B, Makrigiorgos GM. Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples. Nucleic Acids Res. 2004; 32(9):e76.
    View in: PubMed
  26. Chen S, Wang G, Makrigiorgos GM, Price BD. Stable siRNA-mediated silencing of ATM alters the transcriptional profile of HeLa cells. Biochem Biophys Res Commun. 2004 May 14; 317(4):1037-44.
    View in: PubMed
  27. Chen S, Paul P, Price BD. ATM's leucine-rich domain and adjacent sequences are essential for ATM to regulate the DNA damage response. Oncogene. 2003 Sep 25; 22(41):6332-9.
    View in: PubMed
  28. Kaur M, Zhang Y, Liu WH, Tetradis S, Price BD, Makrigiorgos GM. Ligation of a primer at a mutation: a method to detect low level mutations in DNA. Mutagenesis. 2002 Sep; 17(5):365-74.
    View in: PubMed
  29. Makrigiorgos GM, Chakrabarti S, Zhang Y, Kaur M, Price BD. A PCR-based amplification method retaining the quantitative difference between two complex genomes. Nat Biotechnol. 2002 Sep; 20(9):936-9.
    View in: PubMed
  30. Zhang Y, Kaur M, Price BD, Tetradis S, Makrigiorgos GM. An amplification and ligation-based method to scan for unknown mutations in DNA. Hum Mutat. 2002 Aug; 20(2):139-47.
    View in: PubMed
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