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David Saslowsky, Ph.D.

TitleAssistant Professor of Pediatrics
InstitutionChildren's Hospital Boston
DepartmentPediatrics
AddressChildrens Hospital
GI Research, Enders 609
300 Longwood Ave
Boston MA 02115
Phone617/519-8280

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Saslowsky DE, Te Welscher YM, Chinnapen DJ, Wagner JS, Wan J, Kern E, Lencer WI. Ganglioside GM1-mediated Transcytosis of Cholera Toxin Bypasses the Retrograde Pathway and Depends on the Structure of the Ceramide Domain. J Biol Chem. 2013 Sep 6; 288(36):25804-9.
    View in: PubMed
  2. Chinnapen DJ, Hsieh WT, te Welscher YM, Saslowsky DE, Kaoutzani L, Brandsma E, D'Auria L, Park H, Wagner JS, Drake KR, Kang M, Benjamin T, Ullman MD, Costello CE, Kenworthy AK, Baumgart T, Massol RH, Lencer WI. Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1. Dev Cell. 2012 Sep 11; 23(3):573-86.
    View in: PubMed
  3. Tam VC, Suzuki M, Coughlin M, Saslowsky D, Biswas K, Lencer WI, Faruque SM, Mekalanos JJ. Functional analysis of VopF activity required for colonization in Vibrio cholerae. MBio. 2010; 1(5).
    View in: PubMed
  4. Saslowsky DE, Cho JA, Chinnapen H, Massol RH, Chinnapen DJ, Wagner JS, De Luca HE, Kam W, Paw BH, Lencer WI. Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2. J Clin Invest. 2010 Dec; 120(12):4399-4409.
    View in: PubMed
  5. Saslowsky DE, Tanaka N, Reddy KP, Lencer WI. Ceramide activates JNK to inhibit a cAMP-gated K+ conductance and Cl- secretion in intestinal epithelia. FASEB J. 2009 Jan; 23(1):259-70.
    View in: PubMed
  6. Wolf AA, Jobling MG, Saslowsky DE, Kern E, Drake KR, Kenworthy AK, Holmes RK, Lencer WI. Attenuated endocytosis and toxicity of a mutant cholera toxin with decreased ability to cluster ganglioside GM1 molecules. Infect Immun. 2008 Apr; 76(4):1476-84.
    View in: PubMed
  7. Saslowsky DE, Lencer WI. Conversion of apical plasma membrane sphingomyelin to ceramide attenuates the intoxication of host cells by cholera toxin. Cell Microbiol. 2008 Jan; 10(1):67-80.
    View in: PubMed
  8. Chinnapen DJ, Chinnapen H, Saslowsky D, Lencer WI. Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER. FEMS Microbiol Lett. 2007 Jan; 266(2):129-37.
    View in: PubMed
  9. Saslowsky, D.E., Wagner, J.S., Lencer, W.I. regulation of GM1-mediated endocytosis of cholera toxin by membrane sphingomyelin and ceramide. 2006.
  10. Lencer WI, Saslowsky D. Raft trafficking of AB5 subunit bacterial toxins. Biochim Biophys Acta. 2005 Dec 30; 1746(3):314-21.
    View in: PubMed
  11. Saslowsky DE, Warek U, Winkel BS. Nuclear localization of flavonoid enzymes in Arabidopsis. J Biol Chem. 2005 Jun 24; 280(25):23735-40.
    View in: PubMed
  12. David E. Saslowsky and Wayne I. Lencer. Degradation of Sphingomyelin Attenuates Cholera Toxicity in Polarized Epithelia. 2004.
  13. David Saslowsky, Michael Kothe, and Wayne I. Lencer. Cholera toxin: mechanisms of entry into host cells. Microbial Protein Toxins, in Topics in Current Genetics. Schmitt, M. and Schaffrath, R., editors. 2004.
  14. Henderson RM, Edwardson JM, Geisse NA, Saslowsky DE. Lipid rafts: feeling is believing. News Physiol Sci. 2004 Apr; 19:39-43.
    View in: PubMed
  15. Saslowsky, D. and Lencer, W.I. Glycolipid Trafficking of Cholera Toxin by Lipid Rafts. Keystone Symposium on the Molecular Cell Biology of Lipid Domains. 2004.
  16. Saslowsky DE, Lawrence JC, Henderson RM, Edwardson JM. Syntaxin is efficiently excluded from sphingomyelin-enriched domains in supported lipid bilayers containing cholesterol. J Membr Biol. 2003 Aug 1; 194(3):153-64.
    View in: PubMed
  17. Lawrence JC, Saslowsky DE, Edwardson JM, Henderson RM. Real-time analysis of the effects of cholesterol on lipid raft behavior using atomic force microscopy. Biophys J. 2003 Mar; 84(3):1827-32.
    View in: PubMed
  18. Geisse NA, Wäsle B, Saslowsky DE, Henderson RM, Edwardson JM. Syncollin homo-oligomers associate with lipid bilayers in the form of doughnut-shaped structures. J Membr Biol. 2002 Sep 15; 189(2):83-92.
    View in: PubMed
  19. Saslowsky, D., Edwardson, J.M., and Henderson, R.M. Syntaxin is Excluded from Rafts in a Cholesterol-Dependent Manner. European Life Sciences Organization. 2002.
  20. Saslowsky DE, Lawrence J, Ren X, Brown DA, Henderson RM, Edwardson JM. Placental alkaline phosphatase is efficiently targeted to rafts in supported lipid bilayers. J Biol Chem. 2002 Jul 26; 277(30):26966-70.
    View in: PubMed
  21. Saslowsky D, Winkel-Shirley B. Localization of flavonoid enzymes in Arabidopsis roots. Plant J. 2001 Jul; 27(1):37-48.
    View in: PubMed
  22. Saslowsky, D., Edwardson, J.M., and Henderson, R.M. PLAP is Efficiently Targeted to Rafts in Artificial Bilayers. Annual Biophysical Society Meeting. 2001.
  23. David Saslowsky. Molecular Genetics and Subcellular Localization of Flavonoid Metabolism in Arabidopsis. 2000.
  24. Saslowsky DE, Dana CD, Winkel-Shirley B. An allelic series for the chalcone synthase locus in Arabidopsis. Gene. 2000 Sep 19; 255(2):127-38.
    View in: PubMed
  25. Saslowsky, D. and Winkel-Shirley, B.W. Organization of flavonoid metabolism in Arabidopsis. Gordon Conference on Macromolecular Organization and Cell Function. 2000.
  26. Saslowsky, D. and Winkel-Shirley, B.W. Immunolocalization of two flavonoid enzymes in Arabidopsis. 2000.
  27. Saslowsky, D. and Winkel-Shirley, B.W. Organization of flavonoid metabolism in Arabidopsis. 2000.
  28. Winkel-Shirley, B., Burbulis, I.E., Santos, M.O., and Saslowsky, D.E. . Analysis of the flavonoid enzyme complex in Arabidopsis. 16th International Botanical Congress. 1999.
  29. Saslowsky, D. and Winkel-Shirley, B.W. Immunolocalization of two flavonoid enzymes in Arabidopsis. 1999.
  30. Saslowsky, D. and Winkel-Shirley, B.W. Immunolocalization of two flavonoid enzymes in Arabidopsis. 1998.
  31. Saslowsky, D. and Winkel-Shirley, B.W. Analysis of novel chalcone synthase mutants in Arabidopsis. 1998.
  32. Saslowsky, D. and Winkel-Shirley, B.W. Immunolocalization of two flavonoid enzymes in Arabidopsis. 1998.
  33. Saslowsky, D. and Winkel-Shirley, B.W. Organization of flavonoid metabolism in Arabidopsis. 1st International Symposium on Green Fluorescent Protein. 1997.
  34. Cain CC, Saslowsky DE, Walker RA, Shirley BW. Expression of chalcone synthase and chalcone isomerase proteins in Arabidopsis seedlings. Plant Mol Biol. 1997 Oct; 35(3):377-81.
    View in: PubMed
  35. Saslowsky, D. and Winkel-Shirley, B.W. Analysis of novel chalcone synthase mutants in Arabidopsis. 1997.
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