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Last Name
Institution

Douglas J Rhee, M.D.

TitleAssociate Professor of Ophthalmology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology
AddressMassachusetts Eye & Ear Infrm
Glaucoma Service
243 Charles St
Boston MA 02114
Phone617/573-3670
Fax617/573-3707

 Mentoring 
 completed student projects
Testing the Role of SPARC in Intraocular Pressure Regulation in Trabecular Meshwork and Uveoscleral Tract using Dexamethasone and Latanoprost in SPARC Null Mice
Full Time/Year Long, 08/20/07 - 09/01/08
Modulation of Aqueous Humor Outflow Resistance and Outflow Pattern by SPARC
Summer, 05/24/10 - 08/30/10

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Kang MH, Oh DJ, Kang JH, Rhee DJ. Regulation of SPARC by Transforming Growth Factor ß2 in Human Trabecular Meshwork. Invest Ophthalmol Vis Sci. 2013; 54(4):2523-32.
    View in: PubMed
  2. Swaminathan SS, Oh DJ, Kang MH, Ren R, Jin R, Gong H, Rhee DJ. Secreted Protein Acidic and Rich in Cysteine (SPARC)-Null Mice Exhibit More Uniform Outflow. Invest Ophthalmol Vis Sci. 2013; 54(3):2035-47.
    View in: PubMed
  3. Buys ES, Ko YC, Alt C, Hayton SR, Jones A, Tainsh LT, Ren R, Giani A, Clerté M, Abernathy E, Tainsh RE, Oh DJ, Malhotra R, Arora P, de Waard N, Yu B, Turcotte R, Nathan D, Scherrer-Crosbie M, Loomis SJ, Kang JH, Lin CP, Gong H, Rhee DJ, Brouckaert P, Wiggs JL, Gregory MS, Pasquale LR, Bloch KD, Ksander BR. Soluble Guanylate Cyclase a1-Deficient Mice: A Novel Murine Model for Primary Open Angle Glaucoma. PLoS One. 2013; 8(3):e60156.
    View in: PubMed
  4. Jea SY, Filippopoulos T, Vakili G, Francis BA, Rhee DJ. Author reply. Ophthalmology. 2012 Dec; 119(12):2651-2.
    View in: PubMed
  5. Pasquale LR, Loomis SJ, Kang JH, Yaspan BL, Abdrabou W, Budenz DL, Chen TC, Delbono E, Friedman DS, Gaasterland D, Gaasterland T, Grosskreutz CL, Lee RK, Lichter PR, Liu Y, McCarty CA, Moroi SE, Olson LM, Realini T, Rhee DJ, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Allingham RR, Pericak-Vance MA, Weinreb RN, Zhang K, Hauser MA, Richards JE, Haines JL, Wiggs JL. CDKN2B-AS1 Genotype-Glaucoma Feature Correlations in Primary Open-Angle Glaucoma Patients From the United States. Am J Ophthalmol. 2013 Feb; 155(2):342-353.e5.
    View in: PubMed
  6. Haddadin RI, Oh DJ, Kang MH, Villarreal G, Kang JH, Jin R, Gong H, Rhee DJ. Thrombospondin-1 (TSP1)-null and TSP2-null mice exhibit lower intraocular pressures. Invest Ophthalmol Vis Sci. 2012; 53(10):6708-17.
    View in: PubMed
  7. Kronberg BP, Rhee DJ. Anterior segment imaging and the intraocular pressure lowering effect of cataract surgery for open and narrow angle glaucoma. Semin Ophthalmol. 2012 Sep; 27(5-6):154-9.
    View in: PubMed
  8. Jea SY, Mosaed S, Vold SD, Rhee DJ. Effect of a failed trabectome on subsequent trabeculectomy. J Glaucoma. 2012 Feb; 21(2):71-5.
    View in: PubMed
  9. Tanna AP, Budenz DL, Bandi J, Feuer WJ, Feldman RM, Herndon LW, Rhee DJ, Whiteside-de Vos J, Huang J, Anderson DR. Glaucoma Progression Analysis software compared with expert consensus opinion in the detection of visual field progression in glaucoma. Ophthalmology. 2012 Mar; 119(3):468-73.
    View in: PubMed
  10. Jea SY, Francis BA, Vakili G, Filippopoulos T, Rhee DJ. Ab interno trabeculectomy versus trabeculectomy for open-angle glaucoma. Ophthalmology. 2012 Jan; 119(1):36-42.
    View in: PubMed
  11. Chowdhury UR, Jea SY, Oh DJ, Rhee DJ, Fautsch MP. Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye. Invest Ophthalmol Vis Sci. 2011 Aug; 52(9):6443-51.
    View in: PubMed
  12. Jackson ML, Drohan B, Agrawal K, Rhee DJ. Charles Bonnet Syndrome and glaucoma. Ophthalmology. 2011 May; 118(5):1005-1005.e2.
    View in: PubMed
  13. Villarreal G, Oh DJ, Kang MH, Rhee DJ. Coordinated regulation of extracellular matrix synthesis by the microRNA-29 family in the trabecular meshwork. Invest Ophthalmol Vis Sci. 2011 May; 52(6):3391-7.
    View in: PubMed
  14. Fan BJ, Pasquale LR, Rhee D, Li T, Haines JL, Wiggs JL. LOXL1 promoter haplotypes are associated with exfoliation syndrome in a U.S. Caucasian population. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2372-8.
    View in: PubMed
  15. Kang MH, Oh DJ, Rhee DJ. Effect of hevin deletion in mice and characterization in trabecular meshwork. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2187-93.
    View in: PubMed
  16. Brauner SC, Berry JL, Pye J, Lee EG, Rhee DJ. Effect of saline conditions on the tensile strength of ophthalmic sutures. Ophthalmic Surg Lasers Imaging. 2011 Mar-Apr; 42(2):148-51.
    View in: PubMed
  17. Chen LJ, Tam PO, Tham CC, Liang XY, Chiang SW, Canlas O, Ritch R, Rhee DJ, Pang CP. Evaluation of SPARC as a candidate gene of juvenile-onset primary open-angle glaucoma by mutation and copy number analyses. Mol Vis. 2010; 16:2016-25.
    View in: PubMed
  18. Fan BJ, Figuieredo Sena DR, Pasquale LR, Grosskreutz CL, Rhee DJ, Chen TC, Delbono EA, Haines JL, Wiggs JL. Lack of association of polymorphisms in elastin with pseudoexfoliation syndrome and glaucoma. J Glaucoma. 2010 Sep; 19(7):432-6.
    View in: PubMed
  19. Tanna AP, Bandi JR, Budenz DL, Feuer WJ, Feldman RM, Herndon LW, Rhee DJ, Whiteside-de Vos J. Interobserver agreement and intraobserver reproducibility of the subjective determination of glaucomatous visual field progression. Ophthalmology. 2011 Jan; 118(1):60-5.
    View in: PubMed
  20. Rhee DJ, Krad O, Pasquale LR. Hyphema following selective laser trabeculoplasty. Ophthalmic Surg Lasers Imaging. 2009 Sep-Oct; 40(5):493-4.
    View in: PubMed
  21. Ooi YH, Oh DJ, Rhee DJ. Effect of bimatoprost, latanoprost, and unoprostone on matrix metalloproteinases and their inhibitors in human ciliary body smooth muscle cells. Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5259-65.
    View in: PubMed
  22. Ooi YH, Oh DJ, Rhee DJ. Analysis of alpha2-adrenergic receptors and effect of brimonidine on matrix metalloproteinases and their inhibitors in human ciliary body. Invest Ophthalmol Vis Sci. 2009 Sep; 50(9):4237-43.
    View in: PubMed
  23. Rhee DJ. Preventing glaucoma in a high-risk population: impact and observations of the Ocular Hypertension Treatment Study. Arch Ophthalmol. 2009 Feb; 127(2):216-8.
    View in: PubMed
  24. Haddadin RI, Oh DJ, Kang MH, Filippopoulos T, Gupta M, Hart L, Sage EH, Rhee DJ. SPARC-null mice exhibit lower intraocular pressures. Invest Ophthalmol Vis Sci. 2009 Aug; 50(8):3771-7.
    View in: PubMed
  25. Fan BJ, Chen T, Grosskreutz C, Pasquale L, Rhee D, DelBono E, Haines JL, Wiggs JL. Lack of association of polymorphisms in homocysteine metabolism genes with pseudoexfoliation syndrome and glaucoma. Mol Vis. 2008; 14:2484-91.
    View in: PubMed
  26. Rhee DJ, Haddadin RI, Kang MH, Oh DJ. Matricellular proteins in the trabecular meshwork. Exp Eye Res. 2009 Apr; 88(4):694-703.
    View in: PubMed
  27. Allingham RR, Liu Y, Rhee DJ. The genetics of primary open-angle glaucoma: a review. Exp Eye Res. 2009 Apr; 88(4):837-44.
    View in: PubMed
  28. Rhee DJ, Gupta M, Moncavage MB, Moster ML, Moster MR. Idiopathic elevated episcleral venous pressure and open-angle glaucoma. Br J Ophthalmol. 2009 Feb; 93(2):231-4.
    View in: PubMed
  29. Rhee DJ, Peace JH, Mallick S, Landry TA, Bergamini MV. A study of the safety and efficacy of travoprost 0.004%/timolol 0.5% ophthalmic solution compared to latanoprost 0.005% and timolol 0.5% dosed concomitantly in patients with open-angle glaucoma or ocular hypertension. Clin Ophthalmol. 2008 Jun; 2(2):313-9.
    View in: PubMed
  30. Filippopoulos T, Rhee DJ. Novel surgical procedures in glaucoma: advances in penetrating glaucoma surgery. Curr Opin Ophthalmol. 2008 Mar; 19(2):149-54.
    View in: PubMed
  31. Fan BJ, Pasquale L, Grosskreutz CL, Rhee D, Chen T, DeAngelis MM, Kim I, del Bono E, Miller JW, Li T, Haines JL, Wiggs JL. DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity. BMC Med Genet. 2008; 9:5.
    View in: PubMed
  32. Panday VA, Rhee DJ. Review of sulfonamide-induced acute myopia and acute bilateral angle-closure glaucoma. Compr Ophthalmol Update. 2007 Sep-Oct; 8(5):271-6.
    View in: PubMed
  33. Maki JL, Nesti HA, Shetty RK, Rhee DJ. Transcorneal tube extrusion in a child with a Baerveldt glaucoma drainage device. J AAPOS. 2007 Aug; 11(4):395-7.
    View in: PubMed
  34. Hartmann CW, Rhee DJ. The patient's journey: glaucoma. BMJ. 2006 Oct 7; 333(7571):738-9.
    View in: PubMed
  35. Etter JR, Affel EL, Rhee DJ. High prevalence of plateau iris configuration in family members of patients with plateau iris syndrome. J Glaucoma. 2006 Oct; 15(5):394-8.
    View in: PubMed
  36. Oh DJ, Martin JL, Williams AJ, Russell P, Birk DE, Rhee DJ. Effect of latanoprost on the expression of matrix metalloproteinases and their tissue inhibitors in human trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2006 Sep; 47(9):3887-95.
    View in: PubMed
  37. Rhee DJ, Kong DS, Park K, Lee JA. Frequency and prognosis of delayed facial palsy after microvascular decompression for hemifacial spasm. Acta Neurochir (Wien). 2006 Aug; 148(8):839-43; discussion 843.
    View in: PubMed
  38. Rhee DJ, Ramos-Esteban JC, Nipper KS. Rapid resolution of topiramate-induced angle-closure glaucoma with methylprednisolone and mannitol. Am J Ophthalmol. 2006 Jun; 141(6):1133-4.
    View in: PubMed
  39. Kharod BV, Johnson PB, Nesti HA, Rhee DJ. Effect of written instructions on accuracy of self-reporting medication regimen in glaucoma patients. J Glaucoma. 2006 Jun; 15(3):244-7.
    View in: PubMed
  40. Rhee DJ, Peck RE, Belmont J, Martidis A, Liu M, Chang J, Fontanarosa J, Moster MR. Intraocular pressure alterations following intravitreal triamcinolone acetonide. Br J Ophthalmol. 2006 Aug; 90(8):999-1003.
    View in: PubMed
  41. Jones R, Rhee DJ. Corticosteroid-induced ocular hypertension and glaucoma: a brief review and update of the literature. Curr Opin Ophthalmol. 2006 Apr; 17(2):163-7.
    View in: PubMed
  42. Burakgazi AZ, Ozbek Z, Rapuano CJ, Rhee DJ. Long-term complications of iris-claw phakic intraocular lens implantation in Weill-Marchesani syndrome. Cornea. 2006 Apr; 25(3):361-3.
    View in: PubMed
  43. Oh DJ, Martin JL, Williams AJ, Peck RE, Pokorny C, Russell P, Birk DE, Rhee DJ. Analysis of expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human ciliary body after latanoprost. Invest Ophthalmol Vis Sci. 2006 Mar; 47(3):953-63.
    View in: PubMed
  44. Johnson PB, Katz LJ, Rhee DJ. Selective laser trabeculoplasty: predictive value of early intraocular pressure measurements for success at 3 months. Br J Ophthalmol. 2006 Jun; 90(6):741-3.
    View in: PubMed
  45. Farjo AA, Rhee DJ, Soong HK, Meyer RF, Sugar A. Iris-sutured posterior chamber intraocular lens implantation during penetrating keratoplasty. Cornea. 2004 Jan; 23(1):18-28.
    View in: PubMed
  46. Rhee DJ, Tamm ER, Russell P. Donor corneoscleral buttons: a new source of trabecular meshwork for research. Exp Eye Res. 2003 Dec; 77(6):749-56.
    View in: PubMed
  47. Rhee DJ, Fariss RN, Brekken R, Sage EH, Russell P. The matricellular protein SPARC is expressed in human trabecular meshwork. Exp Eye Res. 2003 Nov; 77(5):601-7.
    View in: PubMed
  48. Altangerel U, Spaeth GL, Rhee DJ. Visual function, disability, and psychological impact of glaucoma. Curr Opin Ophthalmol. 2003 Apr; 14(2):100-5.
    View in: PubMed
  49. Takase H, Sugita S, Rhee DJ, Imai Y, Taguchi C, Sugamoto Y, Tagawa Y, Nishihira J, Russell P, Mochizuki M. The presence of macrophage migration inhibitory factor in human trabecular meshwork and its upregulatory effects on the T helper 1 cytokine. Invest Ophthalmol Vis Sci. 2002 Aug; 43(8):2691-6.
    View in: PubMed
  50. Rhee DJ, Spaeth GL, Myers JS, Steinmann WC, Augsburger JJ, Shatz LJ, Terebuh AK, Ritner JA, Katz LJ. Prevalence of the use of complementary and alternative medicine for glaucoma. Ophthalmology. 2002 Mar; 109(3):438-43.
    View in: PubMed
  51. Rhee DJ, Greenfield DS, Chen PP, Schiffman J. Reproducibility of retinal nerve fiber layer thickness measurements using scanning laser polarimetry in pseudophakic eyes. Ophthalmic Surg Lasers. 2002 Mar-Apr; 33(2):117-22.
    View in: PubMed
  52. Spaeth GL, Henderer J, Liu C, Kesen M, Altangerel U, Bayer A, Katz LJ, Myers J, Rhee D, Steinmann W. The disc damage likelihood scale: reproducibility of a new method of estimating the amount of optic nerve damage caused by glaucoma. Trans Am Ophthalmol Soc. 2002; 100:181-5; discussion 185-6.
    View in: PubMed
  53. Rhee DJ, Goldberg MJ, Parrish RK. Bilateral angle-closure glaucoma and ciliary body swelling from topiramate. Arch Ophthalmol. 2001 Nov; 119(11):1721-3.
    View in: PubMed
  54. Rhee DJ, Katz LJ, Spaeth GL, Myers JS. Complementary and alternative medicine for glaucoma. Surv Ophthalmol. 2001 Jul-Aug; 46(1):43-55.
    View in: PubMed
  55. Rhee DJ, Casuso LA, Rosa RH, Budenz DL. Motility disturbance due to true Tenon cyst in a child with a Baerveldt glaucoma drainage implant. Arch Ophthalmol. 2001 Mar; 119(3):440-2.
    View in: PubMed
  56. Rhee DJ, Casuso LA, Budenz DL. Retrograde infusion of fluorescein to confirm location and patency of a glaucoma drainage device. J Glaucoma. 2001 Feb; 10(1):68-70.
    View in: PubMed
  57. Rhee DJ, Deramo VA, Connolly BP, Blecher MH. Intraocular pressure trends after supranormal pressurization to aid closure of sutureless cataract wounds. J Cataract Refract Surg. 1999 Apr; 25(4):546-9.
    View in: PubMed
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