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Dyann Fergus Wirth, Ph.D.

TitleRichard Pearson Strong Professor of Infectious Disease
InstitutionHarvard School of Public Health
DepartmentMalaria/Wirth
AddressHarvard School of Public Health
Bagnoud Bldg
651 Huntington Ave
Boston MA 02115
Phone617/432-2214
Other Positions
TitleDepartment Chair
InstitutionHarvard School of Public Health
DepartmentImmunology and Infectious Diseases


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lukens AK, Ross LS, Heidebrecht R, Javier Gamo F, Lafuente-Monasterio MJ, Booker ML, Hartl DL, Wiegand RC, Wirth DF. Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):799-804.
    View in: PubMed
  2. Joice R, Narasimhan V, Montgomery J, Sidhu AB, Oh K, Meyer E, Pierre-Louis W, Seydel K, Milner D, Williamson K, Wiegand R, Ndiaye D, Daily J, Wirth D, Taylor T, Huttenhower C, Marti M. Inferring developmental stage composition from gene expression in human malaria. PLoS Comput Biol. 2013 Dec; 9(12):e1003392.
    View in: PubMed
  3. Van Tyne D, Dieye B, Valim C, Daniels RF, Sène PD, Lukens AK, Ndiaye M, Bei AK, Ndiaye YD, Hamilton EJ, Ndir O, Mboup S, Volkman SK, Wirth DF, Ndiaye D. Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal. Malar J. 2013; 12:441.
    View in: PubMed
  4. Chang HH, Moss EL, Park DJ, Ndiaye D, Mboup S, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL. Malaria life cycle intensifies both natural selection and random genetic drift. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20129-34.
    View in: PubMed
  5. Hanson KK, Ressurreição AS, Buchholz K, Prudêncio M, Herman-Ornelas JD, Rebelo M, Beatty WL, Wirth DF, Hänscheid T, Moreira R, Marti M, Mota MM. Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):E2838-47.
    View in: PubMed
  6. Van Tyne D, Uboldi AD, Healer J, Cowman AF, Wirth DF. Modulation of PF10_0355 (MSPDBL2) Alters Plasmodium falciparum Response to Antimalarial Drugs. Antimicrob Agents Chemother. 2013 Jul; 57(7):2937-41.
    View in: PubMed
  7. Daniels R, Chang HH, Séne PD, Park DC, Neafsey DE, Schaffner SF, Hamilton EJ, Lukens AK, Van Tyne D, Mboup S, Sabeti PC, Ndiaye D, Wirth DF, Hartl DL, Volkman SK. Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal. PLoS One. 2013; 8(4):e60780.
    View in: PubMed
  8. Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler EA, Wirth DF, Duraisingh MT. Nuclear Repositioning Precedes Promoter Accessibility and Is Linked to the Switching Frequency of a Plasmodium falciparum Invasion Gene. Cell Host Microbe. 2012 Dec 13; 12(6):739-50.
    View in: PubMed
  9. Badiane AS, Sarr O, Deme AB, Ahouidi AD, Gueye PE, Ndiaye M, Seck MC, Diallo M, Bei AK, Duraisingh MT, Wirth D, Ndiaye D, Ndir O, Mboup S. Distribution of erythrocyte binding antigen 175 (EBA-175) alleles and ABO blood groups in a hypoendemic area in Senegal. J Infect Dev Ctries. 2012 Oct; 6(10):727-33.
    View in: PubMed
  10. Park DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C, Ribacke U, Van Tyne D, Galinsky K, Galligan M, Becker JS, Ndiaye D, Mboup S, Wiegand RC, Hartl DL, Sabeti PC, Wirth DF, Volkman SK. Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci U S A. 2012 Aug 7; 109(32):13052-7.
    View in: PubMed
  11. Milner DA, Pochet N, Krupka M, Williams C, Seydel K, Taylor TE, Van de Peer Y, Regev A, Wirth D, Daily JP, Mesirov JP. Transcriptional profiling of Plasmodium falciparum parasites from patients with severe malaria identifies distinct low vs. high parasitemic clusters. PLoS One. 2012; 7(7):e40739.
    View in: PubMed
  12. Chang HH, Park DJ, Galinsky KJ, Schaffner SF, Ndiaye D, Ndir O, Mboup S, Wiegand RC, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL. Genomic Sequencing of Plasmodium falciparum Malaria Parasites from Senegal Reveals the Demographic History of the Population. Mol Biol Evol. 2012 Nov; 29(11):3427-39.
    View in: PubMed
  13. Ly O, Gueye PE, Deme AB, Dieng T, Badiane AS, Ahouidi AD, Diallo M, Bei AK, Wirth DF, Mboup S, Sarr O. Evolution of the pfcrt T76 and pfmdr1 Y86 markers and chloroquine susceptibility 8 years after cessation of chloroquine use in Pikine, Senegal. Parasitol Res. 2012 Oct; 111(4):1541-6.
    View in: PubMed
  14. Amambua-Ngwa A, Park DJ, Volkman SK, Barnes KG, Bei AK, Lukens AK, Sene P, Van Tyne D, Ndiaye D, Wirth DF, Conway DJ, Neafsey DE, Schaffner SF. SNP Genotyping Identifies New Signatures of Selection in a Deep Sample of West African Plasmodium falciparum Malaria Parasites. Mol Biol Evol. 2012 Nov; 29(11):3249-53.
    View in: PubMed
  15. Bustamante C, Folarin OA, Gbotosho GO, Batista CN, Mesquita EA, Brindeiro RM, Tanuri A, Struchiner CJ, Sowunmi A, Oduola A, Wirth DF, Zalis MG, Happi CT. In vitro-reduced susceptibility to artemether in P. falciparum and its association with polymorphisms on transporter genes. J Infect Dis. 2012 Aug 1; 206(3):324-32.
    View in: PubMed
  16. Volkman SK, Neafsey DE, Schaffner SF, Park DJ, Wirth DF. Harnessing genomics and genome biology to understand malaria biology. Nat Rev Genet. 2012 May; 13(5):315-28.
    View in: PubMed
  17. Daniels R, Ndiaye D, Wall M, McKinney J, Séne PD, Sabeti PC, Volkman SK, Mboup S, Wirth DF. Rapid, field-deployable method for genotyping and discovery of single-nucleotide polymorphisms associated with drug resistance in Plasmodium falciparum. Antimicrob Agents Chemother. 2012 Jun; 56(6):2976-86.
    View in: PubMed
  18. Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, Kim YJ, Lee HK, Cortese JF, Wirth DF, Dignam JD, Rao A, Yeo CY, Mazitschek R, Whitman M. Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Mar; 8(3):311-7.
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  19. Milner DA, Vareta J, Valim C, Montgomery J, Daniels RF, Volkman SK, Neafsey DE, Park DJ, Schaffner SF, Mahesh NC, Barnes KG, Rosen DM, Lukens AK, Van Tyne D, Wiegand RC, Sabeti PC, Seydel KB, Glover SJ, Kamiza S, Molyneux ME, Taylor TE, Wirth DF. Human cerebral malaria and Plasmodium falciparum genotypes in Malawi. Malar J. 2012; 11:35.
    View in: PubMed
  20. Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R. Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. Chem Biol. 2011 Dec 23; 18(12):1602-10.
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  21. Volkman SK, Ndiaye D, Diakite M, Koita OA, Nwakanma D, Daniels RF, Park DJ, Neafsey DE, Muskavitch MA, Krogstad DJ, Sabeti PC, Hartl DL, Wirth DF. Application of genomics to field investigations of malaria by the international centers of excellence for malaria research. Acta Trop. 2012 Mar; 121(3):324-32.
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  22. Doumbia SO, Ndiaye D, Koita OA, Diakité M, Nwakanma D, Coulibaly M, Traoré SF, Keating J, Milner DA, Ndiaye JL, Sene PD, Ahouidi A, Dieye TN, Gaye O, Okebe J, Ceesay SJ, Ngwa A, Oriero EC, Konaté L, Sy N, Jawara M, Faye O, Kéita M, Cissé M, Sogoba N, Poudiougou B, Diawara S, Sangaré L, Coulibaly T, Seck I, Abubakar I, Gomis J, Mather FJ, Sissako A, Diarra A, Kandeh B, Whalen C, Moyer B, Nnedu O, Thiero O, Bei AK, Daniels R, Miura K, Long CA, Fairhurst RM, Duraisingh M, Muskavitch MA, D'Alessandro U, Conway DJ, Volkman SK, Valim C, Wirth DF, Krogstad DJ. Improving malaria control in West Africa: interruption of transmission as a paradigm shift. Acta Trop. 2012 Mar; 121(3):175-83.
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  23. Ceesay SJ, Bojang KA, Nwakanma D, Conway DJ, Koita OA, Doumbia SO, Ndiaye D, Coulibaly TF, Diakité M, Traoré SF, Coulibaly M, Ndiaye JL, Sarr O, Gaye O, Konaté L, Sy N, Faye B, Faye O, Sogoba N, Jawara M, Dao A, Poudiougou B, Diawara S, Okebe J, Sangaré L, Abubakar I, Sissako A, Diarra A, Kéita M, Kandeh B, Long CA, Fairhurst RM, Duraisingh M, Perry R, Muskavitch MA, Valim C, Volkman SK, Wirth DF, Krogstad DJ. Sahel, savana, riverine and urban malaria in West Africa: Similar control policies with different outcomes. Acta Trop. 2012 Mar; 121(3):166-74.
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  24. Zhang JJ, Senaratne TN, Daniels R, Valim C, Alifrangis M, Amerasinghe P, Konradsen F, Rajakaruna R, Wirth DF, Karunaweera ND. Distribution pattern of Plasmodium falciparum chloroquine transporter (pfcrt) gene haplotypes in Sri Lanka 1996-2006. Am J Trop Med Hyg. 2011 Nov; 85(5):811-4.
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  25. Melnikov A, Galinsky K, Rogov P, Fennell T, Van Tyne D, Russ C, Daniels R, Barnes KG, Bochicchio J, Ndiaye D, Sene PD, Wirth DF, Nusbaum C, Volkman SK, Birren BW, Gnirke A, Neafsey DE. Hybrid selection for sequencing pathogen genomes from clinical samples. Genome Biol. 2011; 12(8):R73.
    View in: PubMed
  26. Broadbent KM, Park D, Wolf AR, Van Tyne D, Sims JS, Ribacke U, Volkman S, Duraisingh M, Wirth D, Sabeti PC, Rinn JL. A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. Genome Biol. 2011; 12(6):R56.
    View in: PubMed
  27. Buchholz K, Burke TA, Williamson KC, Wiegand RC, Wirth DF, Marti M. A high-throughput screen targeting malaria transmission stages opens new avenues for drug development. J Infect Dis. 2011 May 15; 203(10):1445-53.
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  28. Van Tyne D, Park DJ, Schaffner SF, Neafsey DE, Angelino E, Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA, Johnson CA, Shlyakhter I, Grossman SR, Becker JS, Yamins D, Karlsson EK, Ndiaye D, Sarr O, Mboup S, Happi C, Furlotte NA, Eskin E, Kang HM, Hartl DL, Birren BW, Wiegand RC, Lander ES, Wirth DF, Volkman SK, Sabeti PC. Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet. 2011 Apr; 7(4):e1001383.
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  29. Barker RH, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E. Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Jun; 55(6):2612-22.
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  30. A research agenda for malaria eradication: vaccines. PLoS Med. 2011; 8(1):e1000398.
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  31. Neafsey DE, Lawniczak MK, Park DJ, Redmond SN, Coulibaly MB, Traoré SF, Sagnon N, Costantini C, Johnson C, Wiegand RC, Collins FH, Lander ES, Wirth DF, Kafatos FC, Besansky NJ, Christophides GK, Muskavitch MA. SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes. Science. 2010 Oct 22; 330(6003):514-7.
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  32. Sandhu U, Cebula M, Behme S, Riemer P, Wodarczyk C, Metzger D, Reimann J, Schirmbeck R, Hauser H, Wirth D. Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells. Nucleic Acids Res. 2011 Jan; 39(1):e1.
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  33. Urgaonkar S, Cortese JF, Barker RH, Cromwell M, Serrano AE, Wirth DF, Clardy J, Mazitschek R. A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity. Org Lett. 2010 Sep 17; 12(18):3998-4001.
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  34. Booker ML, Bastos CM, Kramer ML, Barker RH, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem. 2010 Oct 22; 285(43):33054-64.
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  35. Gama-Norton L, Herrmann S, Schucht R, Coroadinha AS, Löw R, Alves PM, Bartholomae CC, Schmidt M, Baum C, Schambach A, Hauser H, Wirth D. Retroviral vector performance in defined chromosomal Loci of modular packaging cell lines. Hum Gene Ther. 2010 Aug; 21(8):979-91.
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  36. Orjuela-Sánchez P, Karunaweera ND, da Silva-Nunes M, da Silva NS, Scopel KK, Gonçalves RM, Amaratunga C, Sá JM, Socheat D, Fairhust RM, Gunawardena S, Thavakodirasah T, Galapaththy GL, Abeysinghe R, Kawamoto F, Wirth DF, Ferreira MU. Single-nucleotide polymorphism, linkage disequilibrium and geographic structure in the malaria parasite Plasmodium vivax: prospects for genome-wide association studies. BMC Genet. 2010; 11:65.
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  37. Zilversmit MM, Volkman SK, DePristo MA, Wirth DF, Awadalla P, Hartl DL. Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome. Mol Biol Evol. 2010 Sep; 27(9):2198-209.
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  38. Ndiaye D, Patel V, Demas A, LeRoux M, Ndir O, Mboup S, Clardy J, Lakshmanan V, Daily JP, Wirth DF. A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials--increased sensitivity of P. falciparum to chloroquine in Senegal. Am J Trop Med Hyg. 2010 Feb; 82(2):228-30.
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  39. Gunawardena S, Karunaweera ND, Ferreira MU, Phone-Kyaw M, Pollack RJ, Alifrangis M, Rajakaruna RS, Konradsen F, Amerasinghe PH, Schousboe ML, Galappaththy GN, Abeyasinghe RR, Hartl DL, Wirth DF. Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. Am J Trop Med Hyg. 2010 Feb; 82(2):235-42.
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  40. Nehlsen K, Herrmann S, Zauers J, Hauser H, Wirth D. Toxin-antitoxin based transgene expression in mammalian cells. Nucleic Acids Res. 2010 Mar; 38(5):e32.
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  41. Wirth D, Daily J, Winzeler E, Mesirov JP, Regev A. In vivo profiles in malaria are consistent with a novel physiological state. Proc Natl Acad Sci U S A. 2009 Jul 7; 106(27):E70; author reply E71-2.
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  42. Patel V, Mazitschek R, Coleman B, Nguyen C, Urgaonkar S, Cortese J, Barker RH, Greenberg E, Tang W, Bradner JE, Schreiber SL, Duraisingh MT, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum. J Med Chem. 2009 Apr 23; 52(8):2185-7.
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  43. Rush MA, Baniecki ML, Mazitschek R, Cortese JF, Wiegand R, Clardy J, Wirth DF. Colorimetric high-throughput screen for detection of heme crystallization inhibitors. Antimicrob Agents Chemother. 2009 Jun; 53(6):2564-8.
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  44. Dharia NV, Sidhu AB, Cassera MB, Westenberger SJ, Bopp SE, Eastman RT, Plouffe D, Batalov S, Park DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler EA. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biol. 2009; 10(2):R21.
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  45. Sims JS, Militello KT, Sims PA, Patel VP, Kasper JM, Wirth DF. Patterns of gene-specific and total transcriptional activity during the Plasmodium falciparum intraerythrocytic developmental cycle. Eukaryot Cell. 2009 Mar; 8(3):327-38.
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  46. Lantos PM, Ahouidi AD, Bei AK, Jennings CV, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT. Erythrocyte invasion profiles are associated with a common invasion ligand polymorphism in Senegalese isolates of Plasmodium falciparum. Parasitology. 2009 Jan; 136(1):1-9.
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  47. Neafsey DE, Schaffner SF, Volkman SK, Park D, Montgomery P, Milner DA, Lukens A, Rosen D, Daniels R, Houde N, Cortese JF, Tyndall E, Gates C, Stange-Thomann N, Sarr O, Ndiaye D, Ndir O, Mboup S, Ferreira MU, Moraes Sdo L, Dash AP, Chitnis CE, Wiegand RC, Hartl DL, Birren BW, Lander ES, Sabeti PC, Wirth DF. Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biol. 2008; 9(12):R171.
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  48. Happi CT, Gbotosho GO, Folarin OA, Sowunmi A, Hudson T, O'Neil M, Milhous W, Wirth DF, Oduola AM. Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria. Antimicrob Agents Chemother. 2009 Mar; 53(3):888-95.
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  49. Dong CK, Patel V, Yang JC, Dvorin JD, Duraisingh MT, Clardy J, Wirth DF. Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors. Bioorg Med Chem Lett. 2009 Feb 1; 19(3):972-5.
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  50. Nunes JK, Starnbach MN, Wirth DF. Secreted antibody is required for immunity to Plasmodium berghei. Infect Immun. 2009 Jan; 77(1):414-8.
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  51. Daniels R, Volkman SK, Milner DA, Mahesh N, Neafsey DE, Park DJ, Rosen D, Angelino E, Sabeti PC, Wirth DF, Wiegand RC. A general SNP-based molecular barcode for Plasmodium falciparum identification and tracking. Malar J. 2008; 7:223.
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  52. Patel V, Booker M, Kramer M, Ross L, Celatka CA, Kennedy LM, Dvorin JD, Duraisingh MT, Sliz P, Wirth DF, Clardy J. Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem. 2008 Dec 12; 283(50):35078-85.
    View in: PubMed
  53. Sarr O, Ahouidi AD, Ly O, Daily JP, Ndiaye D, Ndir O, Mboup S, Wirth DF. Mutations in PFCRT K76T do not correlate with sulfadoxine-pyrimethamine-amodiaquine failure in Pikine, Senegal. Parasitol Res. 2008 Sep; 103(4):765-9.
    View in: PubMed
  54. Mazitschek R, Patel V, Wirth DF, Clardy J. Development of a fluorescence polarization based assay for histone deacetylase ligand discovery. Bioorg Med Chem Lett. 2008 May 1; 18(9):2809-12.
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  55. Karunaweera ND, Ferreira MU, Munasinghe A, Barnwell JW, Collins WE, King CL, Kawamoto F, Hartl DL, Wirth DF. Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax. Gene. 2008 Feb 29; 410(1):105-12.
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  56. Daily JP, Scanfeld D, Pochet N, Le Roch K, Plouffe D, Kamal M, Sarr O, Mboup S, Ndir O, Wypij D, Levasseur K, Thomas E, Tamayo P, Dong C, Zhou Y, Lander ES, Ndiaye D, Wirth D, Winzeler EA, Mesirov JP, Regev A. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature. 2007 Dec 13; 450(7172):1091-5.
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  57. Bethke L, Thomas S, Walker K, Lakhia R, Rangarajan R, Wirth D. The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites. Mol Biochem Parasitol. 2007 Sep; 155(1):18-25.
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  58. Jennings CV, Ahouidi AD, Zilversmit M, Bei AK, Rayner J, Sarr O, Ndir O, Wirth DF, Mboup S, Duraisingh MT. Molecular analysis of erythrocyte invasion in Plasmodium falciparum isolates from Senegal. Infect Immun. 2007 Jul; 75(7):3531-8.
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  59. Gunasekera AM, Myrick A, Le Roch K, Winzeler E, Wirth DF. Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. Exp Parasitol. 2007 Sep; 117(1):87-92.
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  60. Ferreira MU, Karunaweera ND, da Silva-Nunes M, da Silva NS, Wirth DF, Hartl DL. Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia. J Infect Dis. 2007 Apr 15; 195(8):1218-26.
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  61. Gunasekera AM, Wickramarachchi T, Neafsey DE, Ganguli I, Perera L, Premaratne PH, Hartl D, Handunnetti SM, Udagama-Randeniya PV, Wirth DF. Genetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population. Mol Biol Evol. 2007 Apr; 24(4):939-47.
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  62. Gunasekera AM, Myrick A, Militello KT, Sims JS, Dong CK, Gierahn T, Le Roch K, Winzeler E, Wirth DF. Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum. Mol Biochem Parasitol. 2007 May; 153(1):19-30.
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  63. Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, Waggoner S, Onofrio R, Ziaugra L, Mauceli E, Gnerre S, Jaffe DB, Zainoun J, Wiegand RC, Birren BW, Hartl DL, Galagan JE, Lander ES, Wirth DF. A genome-wide map of diversity in Plasmodium falciparum. Nat Genet. 2007 Jan; 39(1):113-9.
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  64. Baniecki ML, Wirth DF, Clardy J. High-throughput Plasmodium falciparum growth assay for malaria drug discovery. Antimicrob Agents Chemother. 2007 Feb; 51(2):716-23.
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  65. Happi CT, Gbotosho GO, Folarin OA, Milner D, Sarr O, Sowunmi A, Kyle DE, Milhous WK, Wirth DF, Oduola AM. Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa. Malar J. 2006; 5:82.
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  66. Ndiaye D, Daily JP, Sarr O, Ndir O, Gaye O, Mboup S, Roper C, Wirth DF. Defining the origin of Plasmodium falciparum resistant dhfr isolates in Senegal. Acta Trop. 2006 Aug; 99(1):106-11.
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  67. Volkman SK, Lozovsky E, Barry AE, Bedford T, Bethke L, Myrick A, Day KP, Hartl DL, Wirth DF, Sawyer SA. Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum. Gene. 2007 Jan 31; 387(1-2):1-6.
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  68. Happi CT, Gbotosho GO, Folarin OA, Sowunmi A, Bolaji OM, Fateye BA, Kyle DE, Milhous W, Wirth DF, Oduola AM. Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria. Parasitol Res. 2006 Dec; 100(1):141-8.
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  69. Bethke LL, Zilversmit M, Nielsen K, Daily J, Volkman SK, Ndiaye D, Lozovsky ER, Hartl DL, Wirth DF. Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum. Mol Biochem Parasitol. 2006 Nov; 150(1):10-24.
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  70. Happi CT, Gbotosho GO, Folarin OA, Bolaji OM, Sowunmi A, Kyle DE, Milhous W, Wirth DF, Oduola AM. Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance 1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria. Am J Trop Med Hyg. 2006 Jul; 75(1):155-61.
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  71. Kidgell C, Volkman SK, Daily J, Borevitz JO, Plouffe D, Zhou Y, Johnson JR, Le Roch K, Sarr O, Ndir O, Mboup S, Batalov S, Wirth DF, Winzeler EA. A systematic map of genetic variation in Plasmodium falciparum. PLoS Pathog. 2006 Jun; 2(6):e57.
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  72. Ndiaye D, Daily JP, Sarr O, Ndir O, Gaye O, Mboup S, Wirth DF. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Senegal. Trop Med Int Health. 2005 Nov; 10(11):1176-9.
    View in: PubMed
  73. Dieng T, Bah IB, Ndiaye PM, Diallo I, Diop BM, Brasseur P, Mboup S, Wirth D, Ndir O. [In vitro evaluation of the sensitivity of Plasmodium falciparum to chloroquine using the deli-microtest in region of Dakar, Senegal]. Med Trop (Mars). 2005 Nov; 65(6):580-3.
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  74. Happi CT, Gbotosho GO, Folarin OA, Akinboye DO, Yusuf BO, Ebong OO, Sowunmi A, Kyle DE, Milhous W, Wirth DF, Oduola AM. Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria. Acta Trop. 2005 Sep; 95(3):183-93.
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  75. Jethwaney D, Lepore T, Hassan S, Mello K, Rangarajan R, Jahnen-Dechent W, Wirth D, Sultan AA. Fetuin-A, a hepatocyte-specific protein that binds Plasmodium berghei thrombospondin-related adhesive protein: a potential role in infectivity. Infect Immun. 2005 Sep; 73(9):5883-91.
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  76. Sarr O, Myrick A, Daily J, Diop BM, Dieng T, Ndir O, Sow PS, Mboup S, Wirth DF. In vivo and in vitro analysis of chloroquine resistance in Plasmodium falciparum isolates from Senegal. Parasitol Res. 2005 Sep; 97(2):136-40.
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  77. Daily JP, Le Roch KG, Sarr O, Ndiaye D, Lukens A, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler EA, Wirth DF. In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. J Infect Dis. 2005 Apr 1; 191(7):1196-203.
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  78. Militello KT, Patel V, Chessler AD, Fisher JK, Kasper JM, Gunasekera A, Wirth DF. RNA polymerase II synthesizes antisense RNA in Plasmodium falciparum. RNA. 2005 Apr; 11(4):365-70.
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  79. Myrick A, Sarr O, Dieng T, Ndir O, Mboup S, Wirth DF. Analysis of the genetic diversity of the Plasmodium falciparum multidrug resistance gene 5' upstream region. Am J Trop Med Hyg. 2005 Feb; 72(2):182-8.
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  80. Emerson LR, Skillman BC, Wolfger H, Kuchler K, Wirth DF. The sensitivities of yeast strains deficient in PDR ABC transporters, to quinoline-ring antimalarial drugs. Ann Trop Med Parasitol. 2004 Sep; 98(6):643-9.
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  81. Daily JP, Le Roch KG, Sarr O, Fang X, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler EA, Wirth DF. In vivo transcriptional profiling of Plasmodium falciparum. Malar J. 2004 Aug 5; 3:30.
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  82. Gunasekera AM, Patankar S, Schug J, Eisen G, Kissinger J, Roos D, Wirth DF. Widespread distribution of antisense transcripts in the Plasmodium falciparum genome. Mol Biochem Parasitol. 2004 Jul; 136(1):35-42.
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  83. Militello KT, Dodge M, Bethke L, Wirth DF. Identification of regulatory elements in the Plasmodium falciparum genome. Mol Biochem Parasitol. 2004 Mar; 134(1):75-88.
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  84. Dodge MA, Waller RF, Chow LM, Zaman MM, Cotton LM, McConville MJ, Wirth DF. Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites. Mol Microbiol. 2004 Mar; 51(6):1563-75.
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  85. Happi CT, Gbotosho GO, Sowunmi A, Falade CO, Akinboye DO, Gerena L, Kyle DE, Milhous W, Wirth DF, Oduola AM. Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria. Am J Trop Med Hyg. 2004 Jan; 70(1):20-6.
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  86. Gunasekera AM, Patankar S, Schug J, Eisen G, Wirth DF. Drug-induced alterations in gene expression of the asexual blood forms of Plasmodium falciparum. Mol Microbiol. 2003 Nov; 50(4):1229-39.
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  87. Myrick A, Munasinghe A, Patankar S, Wirth DF. Mapping of the Plasmodium falciparum multidrug resistance gene 5'-upstream region, and evidence of induction of transcript levels by antimalarial drugs in chloroquine sensitive parasites. Mol Microbiol. 2003 Aug; 49(3):671-83.
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  88. Happi TC, Thomas SM, Gbotosho GO, Falade CO, Akinboye DO, Gerena L, Hudson T, Sowunmi A, Kyle DE, Milhous W, Wirth DF, Oduola AM. Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine, among malaria patients from Nigeria. Ann Trop Med Parasitol. 2003 Jul; 97(5):439-51.
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  89. Chow CS, Wirth DF. Linker scanning mutagenesis of the Plasmodium gallinaceum sexual stage specific gene pgs28 reveals a novel downstream cis-control element. Mol Biochem Parasitol. 2003 Jul; 129(2):199-208.
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  90. Daily JP, Roberts C, Thomas SM, Ndir O, Dieng T, Mboup S, Wirth DF. Prevalence of Plasmodium falciparum pfcrt polymorphisms and in vitro chloroquine sensitivity in Senegal. Parasitology. 2003 May; 126(Pt 5):401-5.
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  91. Nielsen KM, Kasper J, Choi M, Bedford T, Kristiansen K, Wirth DF, Volkman SK, Lozovsky ER, Hartl DL. Gene conversion as a source of nucleotide diversity in Plasmodium falciparum. Mol Biol Evol. 2003 May; 20(5):726-34.
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  92. Volkman SK, Hartl DL, Wirth DF, Nielsen KM, Choi M, Batalov S, Zhou Y, Plouffe D, Le Roch KG, Abagyan R, Winzeler EA. Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science. 2002 Oct 4; 298(5591):216-8.
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  93. Wirth DF. Biological revelations. Nature. 2002 Oct 3; 419(6906):495-6.
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  94. Militello KT, Wirth DF. A new reporter gene for transient transfection of Plasmodium falciparum. Parasitol Res. 2003 Jan; 89(2):154-7.
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  95. Hartl DL, Volkman SK, Nielsen KM, Barry AE, Day KP, Wirth DF, Winzeler EA. The paradoxical population genetics of Plasmodium falciparum. Trends Parasitol. 2002 Jun; 18(6):266-72.
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  96. Thomas SM, Ndir O, Dieng T, Mboup S, Wypij D, Maguire JH, Wirth DF. In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal. Am J Trop Med Hyg. 2002 May; 66(5):474-80.
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  97. Emerson LR, Nau ME, Martin RK, Kyle DE, Vahey M, Wirth DF. Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae. Antimicrob Agents Chemother. 2002 Mar; 46(3):787-96.
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  98. Hirschmann F, Verhoeyen E, Wirth D, Bauwens S, Hauser H, Rudert M. Vital marking of articular chondrocytes by retroviral infection using green fluorescence protein. Osteoarthritis Cartilage. 2002 Feb; 10(2):109-18.
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  99. Trouiller P, Torreele E, Olliaro P, White N, Foster S, Wirth D, Pécoul B. Drugs for neglected diseases: a failure of the market and a public health failure? Trop Med Int Health. 2001 Nov; 6(11):945-51.
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  100. Patankar S, Munasinghe A, Shoaibi A, Cummings LM, Wirth DF. Serial analysis of gene expression in Plasmodium falciparum reveals the global expression profile of erythrocytic stages and the presence of anti-sense transcripts in the malarial parasite. Mol Biol Cell. 2001 Oct; 12(10):3114-25.
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  101. Volkman SK, Barry AE, Lyons EJ, Nielsen KM, Thomas SM, Choi M, Thakore SS, Day KP, Wirth DF, Hartl DL. Recent origin of Plasmodium falciparum from a single progenitor. Science. 2001 Jul 20; 293(5529):482-4.
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  102. Verhoeyen E, Hauser H, Wirth D. Evaluation of retroviral vector design in defined chromosomal loci by Flp-mediated cassette replacement. Hum Gene Ther. 2001 May 20; 12(8):933-44.
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  103. Munasinghe A, Patankar S, Cook BP, Madden SL, Martin RK, Kyle DE, Shoaibi A, Cummings LM, Wirth DF. Serial analysis of gene expression (SAGE) in Plasmodium falciparum: application of the technique to A-T rich genomes. Mol Biochem Parasitol. 2001 Mar; 113(1):23-34.
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  104. Mbacham WF, Chow CS, Daily J, Golightly LM, Wirth DF. Deletion analysis of the 5' flanking sequence of the Plasmodium gallinaceum sexual stage specific gene pgs28 suggests a bipartite arrangement of cis-control elements. Mol Biochem Parasitol. 2001 Mar; 113(1):183-7.
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  105. Patankar S, Fujioka H, Wirth DF. The signal sequence and C-terminal hydrophobic domain are required for localization of the sexual stage antigen pgs28 to the surface of P. gallinaceum ookinetes. Mol Biochem Parasitol. 2000 Dec; 111(2):425-35.
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  106. Vasconcelos KF, Plowe CV, Fontes CJ, Kyle D, Wirth DF, Pereira da Silva LH, Zalis MG. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase of isolates from the Amazon region of Brazil. Mem Inst Oswaldo Cruz. 2000 Sep-Oct; 95(5):721-8.
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  107. Nau ME, Emerson LR, Martin RK, Kyle DE, Wirth DF, Vahey M. Technical assessment of the affymetrix yeast expression GeneChip YE6100 platform in a heterologous model of genes that confer resistance to antimalarial drugs in yeast. J Clin Microbiol. 2000 May; 38(5):1901-8.
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  108. Acuna-Soto R, Maguire JH, Wirth DF. Gender distribution in asymptomatic and invasive amebiasis. Am J Gastroenterol. 2000 May; 95(5):1277-83.
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  109. Golightly LM, Mbacham W, Daily J, Wirth DF. 3' UTR elements enhance expression of Pgs28, an ookinete protein of Plasmodium gallinaceum. Mol Biochem Parasitol. 2000 Jan 5; 105(1):61-70.
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  110. Laserson KF, Petralanda I, Almera R, Barker RH, Spielman A, Maguire JH, Wirth DF. Genetic characterization of an epidemic of Plasmodium falciparum malaria among Yanomami Amerindians. J Infect Dis. 1999 Dec; 180(6):2081-5.
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  111. Saiz M, Ro YT, Wirth DF, Patterson JL. Host cell proteins bind specifically to the capsid-cleaved 5' end of Leishmaniavirus RNA. J Biochem. 1999 Sep; 126(3):538-44.
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  112. Herbst A, Koester M, Wirth D, Hauser H, Welte K. G-CSF receptor mutations in patients with severe congenital neutropenia do not abrogate Jak2 activation and stat1/stat3 translocation. Ann N Y Acad Sci. 1999 Apr 30; 872:320-5; discussion 325-7.
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  113. Dechering KJ, Kaan AM, Mbacham W, Wirth DF, Eling W, Konings RN, Stunnenberg HG. Isolation and functional characterization of two distinct sexual-stage-specific promoters of the human malaria parasite Plasmodium falciparum. Mol Cell Biol. 1999 Feb; 19(2):967-78.
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  114. Wirth D. Malaria: a 21st century solution for an ancient disease. Nat Med. 1998 Dec; 4(12):1360-2.
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  115. Zalis MG, Pang L, Silveira MS, Milhous WK, Wirth DF. Characterization of Plasmodium falciparum isolated from the Amazon region of Brazil: evidence for quinine resistance. Am J Trop Med Hyg. 1998 May; 58(5):630-7.
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  116. Saiz M, Llanos-Cuentas A, Echevarria J, Roncal N, Cruz M, Muniz MT, Lucas C, Wirth DF, Scheffter S, Magill AJ, Patterson JL. Short report: detection of Leishmaniavirus in human biopsy samples of leishmaniasis from Peru. Am J Trop Med Hyg. 1998 Feb; 58(2):192-4.
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  117. Volkman S, Wirth D. Functional analysis of pfmdr1 gene of Plasmodium falciparum. Methods Enzymol. 1998; 292:174-81.
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  118. Perkins ME, Volkman S, Wirth DF, Le Blancq SM. Characterization of an ATP-binding cassette transporter in Cryptosporidium parvum. Mol Biochem Parasitol. 1997 Jul; 87(1):117-22.
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  119. Olliaro P, Cattani J, Wirth D. Malaria, the submerged disease. JAMA. 1996 Jan 17; 275(3):230-3.
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  120. Gueiros-Filho FJ, Viola JP, Gomes FC, Farina M, Lins U, Bertho AL, Wirth DF, Lopes UG. Leishmania amazonensis: multidrug resistance in vinblastine-resistant promastigotes is associated with rhodamine 123 efflux, DNA amplification, and RNA overexpression of a Leishmania mdr1 gene. Exp Parasitol. 1995 Dec; 81(4):480-90.
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  121. Volkman SK, Cowman AF, Wirth DF. Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8921-5.
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  122. Stark K, Schreier E, Müller R, Wirth D, Driesel G, Bienzle U. Prevalence and determinants of anti-HCV seropositivity and of HCV genotype among intravenous drug users in Berlin. Scand J Infect Dis. 1995; 27(4):331-7.
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  123. Wong AK, Curotto de Lafaille MA, Wirth DF. Identification of a cis-acting gene regulatory element from the lemdr1 locus of Leishmania enriettii. J Biol Chem. 1994 Oct 21; 269(42):26497-502.
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  124. Sánchez MA, Peattie DA, Wirth D, Orozco E. Cloning, genomic organization and transcription of the Entamoeba histolytica alpha-tubulin-encoding gene. Gene. 1994 Sep 2; 146(2):239-44.
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  125. Barker RH, Banchongaksorn T, Courval JM, Suwonkerd W, Rimwungtragoon K, Wirth DF. Plasmodium falciparum and P. vivax: factors affecting sensitivity and specificity of PCR-based diagnosis of malaria. Exp Parasitol. 1994 Aug; 79(1):41-9.
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  126. Coutaux AF, Mooney JJ, Wirth DF. Neuronal monoamine reuptake inhibitors enhance in vitro susceptibility to chloroquine in resistant Plasmodium falciparum. Antimicrob Agents Chemother. 1994 Jun; 38(6):1419-21.
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  127. Wong AK, Chow LM, Wirth DF. A homologous recombination strategy to analyze the vinblastine resistance property of the V-circle in Leishmania. Mol Biochem Parasitol. 1994 Mar; 64(1):75-86.
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  128. Zalis MG, Wilson CM, Zhang Y, Wirth DF. Characterization of the pfmdr2 gene for Plasmodium falciparum. Mol Biochem Parasitol. 1994 Feb; 63(2):311.
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  129. Barker RH, Banchongaksorn T, Courval JM, Suwonkerd W, Rimwungtragoon K, Srittong N, Wirth DF. DNA probes as epidemiological tools for surveillance of Plasmodium falciparum malaria in Thailand. Int J Epidemiol. 1994 Feb; 23(1):161-8.
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  130. Driesel G, Wirth D, Stark K, Baumgarten R, Sucker U, Schreier E. Hepatitis C virus (HCV) genotype distribution in German isolates: studies on the sequence variability in the E2 and NS5 region. Arch Virol. 1994; 139(3-4):379-88.
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  131. Tobin JF, Wirth DF. Mutational analysis of a signal sequence required for protein secretion in Leishmania major. Mol Biochem Parasitol. 1993 Dec; 62(2):243-9.
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  132. Zalis MG, Wilson CM, Zhang Y, Wirth DF. Characterization of the pfmdr2 gene for Plasmodium falciparum. Mol Biochem Parasitol. 1993 Nov; 62(1):83-92.
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  133. Chow LM, Wong AK, Ullman B, Wirth DF. Cloning and functional analysis of an extrachromosomally amplified multidrug resistance-like gene in Leishmania enriettii. Mol Biochem Parasitol. 1993 Aug; 60(2):195-208.
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  134. Iralu JV, Sritharan VK, Pieciak WS, Wirth DF, Maguire JH, Barker RH. Diagnosis of Mycobacterium avium bacteremia by polymerase chain reaction. J Clin Microbiol. 1993 Jul; 31(7):1811-4.
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  135. Hendrickson N, Sifri CD, Henderson DM, Allen T, Wirth DF, Ullman B. Molecular characterization of the ldmdr1 multidrug resistance gene from Leishmania donovani. Mol Biochem Parasitol. 1993 Jul; 60(1):53-64.
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  136. Tobin JF, Reiner SL, Hatam F, Zheng S, Leptak CL, Wirth DF, Locksley RM. Transfected Leishmania expressing biologically active IFN-gamma. J Immunol. 1993 Jun 1; 150(11):5059-69.
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  137. Goonewardene R, Daily J, Kaslow D, Sullivan TJ, Duffy P, Carter R, Mendis K, Wirth D. Transfection of the malaria parasite and expression of firefly luciferase. Proc Natl Acad Sci U S A. 1993 Jun 1; 90(11):5234-6.
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  138. Volkman SK, Wilson CM, Wirth DF. Stage-specific transcripts of the Plasmodium falciparum pfmdr 1 gene. Mol Biochem Parasitol. 1993 Feb; 57(2):203-11.
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  139. Wilson CM, Volkman SK, Thaithong S, Martin RK, Kyle DE, Milhous WK, Wirth DF. Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand. Mol Biochem Parasitol. 1993 Jan; 57(1):151-60.
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  140. Fontanet AL, Johnston DB, Walker AM, Rooney W, Thimasarn K, Sturchler D, Macdonald M, Hours M, Wirth DF. High prevalence of mefloquine-resistant falciparum malaria in eastern Thailand. Bull World Health Organ. 1993; 71(3-4):377-83.
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  141. Acuna-Soto R, Samuelson J, De Girolami P, Zarate L, Millan-Velasco F, Schoolnick G, Wirth D. Application of the polymerase chain reaction to the epidemiology of pathogenic and nonpathogenic Entamoeba histolytica. Am J Trop Med Hyg. 1993 Jan; 48(1):58-70.
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  142. Curotto de Lafaille MA, Wirth DF. Creation of Null/+ mutants of the alpha-tubulin gene in Leishmania enriettii by gene cluster deletion. J Biol Chem. 1992 Nov 25; 267(33):23839-46.
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  143. Henderson DM, Sifri CD, Rodgers M, Wirth DF, Hendrickson N, Ullman B. Multidrug resistance in Leishmania donovani is conferred by amplification of a gene homologous to the mammalian mdr1 gene. Mol Cell Biol. 1992 Jun; 12(6):2855-65.
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  144. Barker RH, Banchongaksorn T, Courval JM, Suwonkerd W, Rimwungtragoon K, Wirth DF. A simple method to detect Plasmodium falciparum directly from blood samples using the polymerase chain reaction. Am J Trop Med Hyg. 1992 Apr; 46(4):416-26.
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  145. Curotto de Lafaille MA, Laban A, Wirth DF. Gene expression in Leishmania: analysis of essential 5' DNA sequences. Proc Natl Acad Sci U S A. 1992 Apr 1; 89(7):2703-7.
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  146. Tobin JF, Wirth DF. A sequence insertion targeting vector for Leishmania enriettii. J Biol Chem. 1992 Mar 5; 267(7):4752-8.
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  147. Fries JW, Patel RJ, Piessens WF, Wirth DF. Detection of untreated mycobacteria by using polymerase chain reaction and specific DNA probes. J Clin Microbiol. 1991 Aug; 29(8):1744-7.
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  148. Tobin JF, Laban A, Wirth DF. Homologous recombination in Leishmania enriettii. Proc Natl Acad Sci U S A. 1991 Feb 1; 88(3):864-8.
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  149. Laskay T, Kiessling R, Rinke deWit TF, Wirth DF. Generation of species-specific DNA probes for Leishmania aethiopica. Mol Biochem Parasitol. 1991 Feb; 44(2):279-86.
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  150. Rodgers MR, Popper SJ, Wirth DF. Amplification of kinetoplast DNA as a tool in the detection and diagnosis of Leishmania. Exp Parasitol. 1990 Oct; 71(3):267-75.
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  151. Ayala P, Samuelson J, Wirth D, Orozco E. Entamoeba histolytica: physiology of multidrug resistance. Exp Parasitol. 1990 Aug; 71(2):169-75.
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  152. Fries JW, Patel RJ, Piessens WF, Wirth DF. Genus- and species-specific DNA probes to identify mycobacteria using the polymerase chain reaction. Mol Cell Probes. 1990 Apr; 4(2):87-105.
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  153. Patel RJ, Fries JW, Piessens WF, Wirth DF. Sequence analysis and amplification by polymerase chain reaction of a cloned DNA fragment for identification of Mycobacterium tuberculosis. J Clin Microbiol. 1990 Mar; 28(3):513-8.
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  154. Laban A, Tobin JF, Curotto de Lafaille MA, Wirth DF. Stable expression of the bacterial neor gene in Leishmania enriettii. Nature. 1990 Feb 8; 343(6258):572-4.
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  155. Samuelson J, Ayala P, Orozco E, Wirth D. Emetine-resistant mutants of Entamoeba histolytica overexpress mRNAs for multidrug resistance. Mol Biochem Parasitol. 1990 Jan 15; 38(2):281-90.
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  156. Ayala P, Samuelson J, Wirth D, Orozco E. [Multidrug resistance in Entamoeba histolytica]. Arch Invest Med (Mex). 1990; 21 Suppl 1:103-7.
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  157. Laban A, Wirth DF. Transfection of Leishmania enriettii and expression of chloramphenicol acetyltransferase gene. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9119-23.
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  158. Barker RH, Brandling-Bennett AD, Koech DK, Mugambi M, Khan B, David R, David JR, Wirth DF. Plasmodium falciparum: DNA probe diagnosis of malaria in Kenya. Exp Parasitol. 1989 Oct; 69(3):226-33.
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  159. Barker RH, Suebsaeng L, Rooney W, Wirth DF. Detection of Plasmodium falciparum infection in human patients: a comparison of the DNA probe method to microscopic diagnosis. Am J Trop Med Hyg. 1989 Sep; 41(3):266-72.
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  160. Aldritt SM, Joseph JT, Wirth DF. Sequence identification of cytochrome b in Plasmodium gallinaceum. Mol Cell Biol. 1989 Sep; 9(9):3614-20.
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  161. Joseph JT, Aldritt SM, Unnasch T, Puijalon O, Wirth DF. Characterization of a conserved extrachromosomal element isolated from the avian malarial parasite Plasmodium gallinaceum. Mol Cell Biol. 1989 Sep; 9(9):3621-9.
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  162. Widmer G, Comeau AM, Furlong DB, Wirth DF, Patterson JL. Characterization of a RNA virus from the parasite Leishmania. Proc Natl Acad Sci U S A. 1989 Aug; 86(15):5979-82.
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  163. Meredith SE, Unnasch TR, Karam M, Piessens WF, Wirth DF. Cloning and characterization of an Onchocerca volvulus specific DNA sequence. Mol Biochem Parasitol. 1989 Aug; 36(1):1-10.
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  164. Wilson CM, Serrano AE, Wasley A, Bogenschutz MP, Shankar AH, Wirth DF. Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum. Science. 1989 Jun 9; 244(4909):1184-6.
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  165. Samuelson J, Acuna-Soto R, Reed S, Biagi F, Wirth D. DNA hybridization probe for clinical diagnosis of Entamoeba histolytica. J Clin Microbiol. 1989 Apr; 27(4):671-6.
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  166. Patel RJ, Piessens WF, David JR, Wirth DF. A cloned DNA fragment for identification of Mycobacterium tuberculosis. Rev Infect Dis. 1989 Mar-Apr; 11 Suppl 2:S411-9.
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  167. Waters AP, Unnasch TR, Wirth DF, McCutchan TF. Sequence of a small ribosomal RNA gene from Plasmodium lophurae. Nucleic Acids Res. 1989 Feb 25; 17(4):1763.
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  168. Lanar DE, McLaughlin GL, Wirth DF, Barker RJ, Zolg JW, Chulay JD. Comparison of thick films, in vitro culture and DNA hybridization probes for detecting Plasmodium falciparum malaria. Am J Trop Med Hyg. 1989 Jan; 40(1):3-6.
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  169. Wirth DF, Rogers WO, Barker R, Dourado H, Suesbang L, Albuquerque B. Leishmaniasis and malaria: DNA probes for diagnosis and epidemiologic analysis. Ann N Y Acad Sci. 1989; 569:183-92.
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  170. Rogers WO, Burnheim PF, Wirth DF. Detection of Leishmania within sand flies by kinetoplast DNA hybridization. Am J Trop Med Hyg. 1988 Nov; 39(5):434-9.
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  171. Rogers WO, Wirth DF. Generation of sequence diversity in the kinetoplast DNA minicircles of Leishmania mexicana amazonensis. Mol Biochem Parasitol. 1988 Jul; 30(1):1-8.
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  172. Miller SI, Wirth DF. trans splicing in Leishmania enriettii and identification of ribonucleoprotein complexes containing the spliced leader and U2 equivalent RNAs. Mol Cell Biol. 1988 Jun; 8(6):2597-603.
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  173. Shah JS, Karam M, Piessens WF, Wirth DF. Characterization of an Onchocerca-specific DNA clone from Onchocerca volvulus. Am J Trop Med Hyg. 1987 Sep; 37(2):376-84.
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  174. Wirth DF, Barker RH. Response: malaria diagnosis. Science. 1987 Apr 3; 236(4797):12.
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  175. Rogers WO, Wirth DF. Kinetoplast DNA minicircles: regions of extensive sequence divergence. Proc Natl Acad Sci U S A. 1987 Jan; 84(2):565-9.
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  176. Sim BK, Shah J, Wirth DF, Piessens WF. Characterization of the filarial genome. Ciba Found Symp. 1987; 127:107-24.
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  177. Landfear SM, Miller SI, Wirth DF. Transcriptional mapping of Leishmania enrietti tubulin mRNAs. Mol Biochem Parasitol. 1986 Dec; 21(3):235-45.
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  178. Wirth DF, Rogers WO, Barker R, Dourado H, Suesebang L, Albuquerque B. Leishmaniasis and malaria: new tools for epidemiologic analysis. Science. 1986 Nov 21; 234(4779):975-9.
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  179. Comeau AM, Miller SI, Wirth DF. Chromosome location of four genes in Leishmania. Mol Biochem Parasitol. 1986 Nov; 21(2):161-9.
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  180. Miller SI, Landfear SM, Wirth DF. Cloning and characterization of a Leishmania gene encoding a RNA spliced leader sequence. Nucleic Acids Res. 1986 Sep 25; 14(18):7341-60.
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  181. Lopes UG, Wirth DF. Identification of visceral Leishmania species with cloned sequences of kinetoplast DNA. Mol Biochem Parasitol. 1986 Jul; 20(1):77-84.
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  182. Sim BK, Mak JW, Cheong WH, Sutanto I, Kurniawan L, Marwoto HA, Franke E, Campell JR, Wirth DF, Piessens WF, et al. Identification of Brugia malayi in vectors with a species-specific DNA probe. Am J Trop Med Hyg. 1986 May; 35(3):559-64.
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  183. Sim BK, Piessens WF, Wirth DF. A DNA probe cloned in Escherichia coli for the identification of Brugia malayi. Mol Biochem Parasitol. 1986 May; 19(2):117-23.
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  184. Shah JS, Lamontagne L, Unnasch TR, Wirth DF, Piessens WF. Characterization of a ribosomal DNA clone of Brugia malayi. Mol Biochem Parasitol. 1986 Apr; 19(1):67-75.
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  185. Barker RH, Suebsaeng L, Rooney W, Alecrim GC, Dourado HV, Wirth DF. Specific DNA probe for the diagnosis of Plasmodium falciparum malaria. Science. 1986 Mar 21; 231(4744):1434-6.
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  186. Unnasch TR, McLafferty M, Wirth DF. The primary structure of the rRNA insertions of Plasmodium lophurae. Mol Biochem Parasitol. 1985 Aug; 16(2):149-61.
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  187. Landfear SM, Wirth DF. Structure of mRNA encoded by tubulin genes in Leishmania enriettii. Mol Biochem Parasitol. 1985 Apr; 15(1):61-82.
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  188. Carter R, Miller LH, Rener J, Kaushal DC, Kumar N, Graves PM, Grotendorst CA, Gwadz RW, French C, Wirth D. Target antigens in malaria transmission blocking immunity. Philos Trans R Soc Lond B Biol Sci. 1984 Nov 13; 307(1131):201-13.
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  189. Landfear SM, Wirth DF. Control of tubulin gene expression in the parasitic protozoan Leishmania enriettii. Nature. 1984 Jun 21-27; 309(5970):716-7.
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  190. Unnasch TR, Wirth DF. The avian malaria Plasmodium lophurae has a small number of heterogeneous ribosomal RNA genes. Nucleic Acids Res. 1983 Dec 10; 11(23):8443-59.
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  191. Unnasch TR, Wirth DF. The cloned rRNA genes of P. lophurae: a novel rDNA structure. Nucleic Acids Res. 1983 Dec 10; 11(23):8461-72.
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  192. Wirth DF, Slater C. Isolation and characterization of an alpha-tubulin gene from Leishmania enriettii. Mol Biochem Parasitol. 1983 Sep; 9(1):83-92.
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  193. Landfear SM, McMahon-Pratt D, Wirth DF. Tandem arrangement of tubulin genes in the protozoan parasite Leishmania enriettii. Mol Cell Biol. 1983 Jun; 3(6):1070-6.
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  194. Wirth DF, Pratt DM. Rapid identification of Leishmania species by specific hybridization of kinetoplast DNA in cutaneous lesions. Proc Natl Acad Sci U S A. 1982 Nov; 79(22):6999-7003.
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  195. Robbins PW, Wirth DF, Hering C. Expression of the Streptomyces enzyme endoglycosidase H in Escherichia coli. J Biol Chem. 1981 Oct 25; 256(20):10640-4.
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  196. Lodish HF, Wirth D, Porter M. Synthesis and assembly of viral membrane proteins. Ann N Y Acad Sci. 1980; 343:319-37.
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  197. Wirth DF, Katz F, Small B, Lodish HF. How a single Sindbis virus mRNA directs the synthesis of one soluble protein and two integral membrane glycoproteins. Cell. 1977 Feb; 10(2):253-63.
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