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Keywords
Last Name
Institution

Roland Baron, Ph.D., D.D.S.

TitleProfessor of Oral Medicine, Infection, and Immunity
InstitutionHarvard School of Dental Medicine
DepartmentOral Med - Infection + Immunity
AddressHarvard School of Dental Medicine
Oral Medicine, Infection & Immunity
188 Longwood Ave
Boston MA 02115
Phone617/432-7320
Fax617/432-1897
Other Positions
TitleHead of the Department of Oral Medicine, Infection, and Immunity
InstitutionHarvard School of Dental Medicine
DepartmentOral Med - Infection + Immunity

TitleProfessor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
DivisionEndocrinology


 Biography 
 awards and honors
1972 - 1972Silver Medal, Thesis Prize for the Ph.D. Thesis
1993 - 2003Merit Award
1997 - 1997Seymour J, Kreshover Lecture Award
2002 - 2002Doctor Honoris Causa
2002 - 2002Japan Society for Promotion of Science Travel Grant
2002 - 2002Louis V, Avioli Founders Award
2005 - 2005D. Harold Copp Award in Basic Research

 Mentoring 
 completed student projects
The Role of Insulin of Bone Growth, and the Relation to DeltaFosB/AP1
Summer, 06/20/11 - 08/12/11

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Biosse Duplan M, Zalli D, Stephens S, Zenger S, Neff L, Oelkers JM, Lai FP, Horne W, Rottner K, Baron R. Microtubule Dynamic Instability Controls Podosome Patterning in Osteoclasts through EB1, Cortactin, and Src. Mol Cell Biol. 2014 Jan; 34(1):16-29.
    View in: PubMed
  2. Nallamshetty S, Wang H, Rhee EJ, Kiefer FW, Brown JD, Lotinun S, Le P, Baron R, Rosen CJ, Plutzky J. Deficiency of Retinaldehyde Dehydrogenase 1 Induces BMP2 and Increases Bone Mass In Vivo. PLoS One. 2013; 8(8):e71307.
    View in: PubMed
  3. Saini V, Marengi DA, Barry KJ, Fulzele KS, Heiden E, Liu X, Dedic C, Maeda A, Lotinun S, Baron R, Pajevic PD. Parathyroid Hormone (PTH)/PTH-related Peptide Type 1 Receptor (PPR) Signaling in Osteocytes Regulates Anabolic and Catabolic Skeletal Responses to PTH. J Biol Chem. 2013 Jul 12; 288(28):20122-34.
    View in: PubMed
  4. Kiviranta R, Yamana K, Saito H, Ho DK, Laine J, Tarkkonen K, Nieminen-Pihala V, Hesse E, Correa D, Määttä J, Tessarollo L, Rosen ED, Horne WC, Jenkins NA, Copeland NG, Warming S, Baron R. Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages. J Exp Med. 2013 May 6; 210(5):969-85.
    View in: PubMed
  5. Biosse-Duplan M, Stephens S, Lai FP, Oelkers M, Kitamura D, Rottner K, Horne W, Baron R. Retraction: The association between the microtubule plus end protein EB1 and cortactin controls podosomes and bone resorption. J Bone Miner Res. 2013 Apr; 28(4):970.
    View in: PubMed
  6. Baron R, Kneissel M. WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med. 2013 Feb; 19(2):179-92.
    View in: PubMed
  7. Coury F, Zenger S, Stewart AK, Stephens S, Neff L, Tsang K, Shull GE, Alper SL, Baron R, Aliprantis AO. SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts. Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6):2163-8.
    View in: PubMed
  8. Lotinun S, Kiviranta R, Matsubara T, Alzate JA, Neff L, Lüth A, Koskivirta I, Kleuser B, Vacher J, Vuorio E, Horne WC, Baron R. Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation. J Clin Invest. 2013 Feb 1; 123(2):666-81.
    View in: PubMed
  9. Idelevich A, Sato K, Baron R. What are the effects of leptin on bone and where are they exerted? J Bone Miner Res. 2013 Jan; 28(1):18-21.
    View in: PubMed
  10. Kang S, Akerblad P, Kiviranta R, Gupta RK, Kajimura S, Griffin MJ, Min J, Baron R, Rosen ED. Regulation of early adipose commitment by zfp521. PLoS Biol. 2012 Nov; 10(11):e1001433.
    View in: PubMed
  11. Liu Y, Berendsen AD, Jia S, Lotinun S, Baron R, Ferrara N, Olsen BR. Intracellular VEGF regulates the balance between osteoblast and adipocyte differentiation. J Clin Invest. 2012 Sep 4; 122(9):3101-13.
    View in: PubMed
  12. Rowe GC, Vialou V, Sato K, Saito H, Yin M, Green TA, Lotinun S, Kveiborg M, Horne WC, Nestler EJ, Baron R. Energy expenditure and bone formation share a common sensitivity to AP-1 transcription in the hypothalamus. J Bone Miner Res. 2012 Aug; 27(8):1649-58.
    View in: PubMed
  13. Lotinun S, Pearsall RS, Horne WC, Baron R. Activin receptor signaling: a potential therapeutic target for osteoporosis. Curr Mol Pharmacol. 2012 Jun; 5(2):195-204.
    View in: PubMed
  14. Baron R, Saito H, Gori F. Bone cells crosstalk: noncanonical roring in the wnt. Cell Metab. 2012 Apr 4; 15(4):415-7.
    View in: PubMed
  15. Baron R, Hesse E. Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives. J Clin Endocrinol Metab. 2012 Feb; 97(2):311-25.
    View in: PubMed
  16. Baron R. Osteoporosis in 2011: Osteoporosis therapy--dawn of the post-bisphosphonate era. Nat Rev Endocrinol. 2012 Feb; 8(2):76-8.
    View in: PubMed
  17. Zou W, Greenblatt MB, Shim JH, Kant S, Zhai B, Lotinun S, Brady N, Hu DZ, Gygi SP, Baron R, Davis RJ, Jones D, Glimcher LH. MLK3 regulates bone development downstream of the faciogenital dysplasia protein FGD1 in mice. J Clin Invest. 2011 Nov; 121(11):4383-92.
    View in: PubMed
  18. Motyl KJ, Dick-de-Paula I, Maloney AE, Lotinun S, Bornstein S, de Paula FJ, Baron R, Houseknecht KL, Rosen CJ. Trabecular bone loss after administration of the second-generation antipsychotic risperidone is independent of weight gain. Bone. 2012 Feb; 50(2):490-8.
    View in: PubMed
  19. Marzia M, Guaiquil V, Horne WC, Blobel CP, Baron R, Chiusaroli R. Lack of ADAM15 in mice is associated with increased osteoblast function and bone mass. Biol Chem. 2011 Oct; 392(10):877-85.
    View in: PubMed
  20. de Paula FJ, Dick-de-Paula I, Bornstein S, Rostama B, Le P, Lotinun S, Baron R, Rosen CJ. VDR haploinsufficiency impacts body composition and skeletal acquisition in a gender-specific manner. Calcif Tissue Int. 2011 Sep; 89(3):179-91.
    View in: PubMed
  21. Seriwatanachai D, Densmore MJ, Sato T, Correa D, Neff L, Baron R, Lanske B. Deletion of Zfp521 rescues the growth plate phenotype in a mouse model of Jansen metaphyseal chondrodysplasia. FASEB J. 2011 Sep; 25(9):3057-67.
    View in: PubMed
  22. Moisan A, Rivera MN, Lotinun S, Akhavanfard S, Coffman EJ, Cook EB, Stoykova S, Mukherjee S, Schoonmaker JA, Burger A, Kim WJ, Kronenberg HM, Baron R, Haber DA, Bardeesy N. The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification. Dev Cell. 2011 May 17; 20(5):583-96.
    View in: PubMed
  23. Christov M, Koren S, Yuan Q, Baron R, Lanske B. Genetic ablation of sfrp4 in mice does not affect serum phosphate homeostasis. Endocrinology. 2011 May; 152(5):2031-6.
    View in: PubMed
  24. Hesse E, Saito H, Kiviranta R, Correa D, Yamana K, Neff L, Toben D, Duda G, Atfi A, Geoffroy V, Horne WC, Baron R. Zfp521 controls bone mass by HDAC3-dependent attenuation of Runx2 activity. J Cell Biol. 2010 Dec 27; 191(7):1271-83.
    View in: PubMed
  25. Baron R, Ferrari S, Russell RG. Denosumab and bisphosphonates: different mechanisms of action and effects. Bone. 2011 Apr 1; 48(4):677-92.
    View in: PubMed
  26. Correa D, Hesse E, Seriwatanachai D, Kiviranta R, Saito H, Yamana K, Neff L, Atfi A, Coillard L, Sitara D, Maeda Y, Warming S, Jenkins NA, Copeland NG, Horne WC, Lanske B, Baron R. Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell. 2010 Oct 19; 19(4):533-46.
    View in: PubMed
  27. Devlin MJ, Cloutier AM, Thomas NA, Panus DA, Lotinun S, Pinz I, Baron R, Rosen CJ, Bouxsein ML. Caloric restriction leads to high marrow adiposity and low bone mass in growing mice. J Bone Miner Res. 2010 Sep; 25(9):2078-88.
    View in: PubMed
  28. Greenblatt MB, Shim JH, Zou W, Sitara D, Schweitzer M, Hu D, Lotinun S, Sano Y, Baron R, Park JM, Arthur S, Xie M, Schneider MD, Zhai B, Gygi S, Davis R, Glimcher LH. The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice. J Clin Invest. 2010 Jul; 120(7):2457-73.
    View in: PubMed
  29. Schulze J, Seitz S, Saito H, Schneebauer M, Marshall RP, Baranowsky A, Busse B, Schilling AF, Friedrich FW, Albers J, Spiro AS, Zustin J, Streichert T, Ellwanger K, Niehrs C, Amling M, Baron R, Schinke T. Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2. PLoS One. 2010; 5(4):e10309.
    View in: PubMed
  30. Atfi A, Baron R. PTH battles TGF-beta in bone. Nat Cell Biol. 2010 Mar; 12(3):205-7.
    View in: PubMed
  31. Hesse E, Kiviranta R, Wu M, Saito H, Yamana K, Correa D, Atfi A, Baron R. Zinc finger protein 521, a new player in bone formation. Ann N Y Acad Sci. 2010 Mar; 1192:32-7.
    View in: PubMed
  32. Guo J, Liu M, Yang D, Bouxsein ML, Saito H, Galvin RJ, Kuhstoss SA, Thomas CC, Schipani E, Baron R, Bringhurst FR, Kronenberg HM. Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation. Cell Metab. 2010 Feb 3; 11(2):161-71.
    View in: PubMed
  33. Lotinun S, Pearsall RS, Davies MV, Marvell TH, Monnell TE, Ucran J, Fajardo RJ, Kumar R, Underwood KW, Seehra J, Bouxsein ML, Baron R. A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys. Bone. 2010 Apr; 46(4):1082-8.
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  34. Purev E, Neff L, Horne WC, Baron R. c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes. Mol Biol Cell. 2009 Sep; 20(18):4021-30.
    View in: PubMed
  35. Nakajima A, Sanjay A, Chiusaroli R, Adapala NS, Neff L, Itzsteink C, Horne WC, Baron R. Loss of Cbl-b increases osteoclast bone-resorbing activity and induces osteopenia. J Bone Miner Res. 2009 Jul; 24(7):1162-72.
    View in: PubMed
  36. Bruzzaniti A, Neff L, Sandoval A, Du L, Horne WC, Baron R. Dynamin reduces Pyk2 Y402 phosphorylation and SRC binding in osteoclasts. Mol Cell Biol. 2009 Jul; 29(13):3644-56.
    View in: PubMed
  37. Alles N, Soysa NS, Hussain MD, Tomomatsu N, Saito H, Baron R, Morimoto N, Aoki K, Akiyoshi K, Ohya K. Polysaccharide nanogel delivery of a TNF-alpha and RANKL antagonist peptide allows systemic prevention of bone loss. Eur J Pharm Sci. 2009 May 12; 37(2):83-8.
    View in: PubMed
  38. Wu M, Hesse E, Morvan F, Zhang JP, Correa D, Rowe GC, Kiviranta R, Neff L, Philbrick WM, Horne WC, Baron R. Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivo. Bone. 2009 Apr; 44(4):528-36.
    View in: PubMed
  39. Rowe GC, Choi CS, Neff L, Horne WC, Shulman GI, Baron R. Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice. Endocrinology. 2009 Jan; 150(1):135-43.
    View in: PubMed
  40. Atfi A, Baron R. p53 brings a new twist to the Smad signaling network. Sci Signal. 2008; 1(26):pe33.
    View in: PubMed
  41. Ellwanger K, Saito H, Clément-Lacroix P, Maltry N, Niedermeyer J, Lee WK, Baron R, Rawadi G, Westphal H, Niehrs C. Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density. Mol Cell Biol. 2008 Aug; 28(15):4875-82.
    View in: PubMed
  42. Sabatakos G, Rowe GC, Kveiborg M, Wu M, Neff L, Chiusaroli R, Philbrick WM, Baron R. Doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity. J Bone Miner Res. 2008 May; 23(5):584-95.
    View in: PubMed
  43. Sabatakos G. Rowe GC, Kveiborg M, Wu M, Neff L, Chiusaroli R, Philbrick WM, Baron R. The doubly truncated FosB isoform (Delta2DeltaFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of intrinsic AP-1 activity. J Bone and Min. Res. 2008; 23:584-595.
  44. Wang L, Tassiulas I, Park-Min KH, Reid AC, Gil-Henn H, Schlessinger J, Baron R, Zhang JJ, Ivashkiv LB. 'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages. Nat Immunol. 2008 Feb; 9(2):186-93.
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  45. Destaing O, Sanjay A, Itzstein C, Horne WC, Toomre D, De Camilli P, Baron R. The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts. Mol Biol Cell. 2008 Jan; 19(1):394-404.
    View in: PubMed
  46. Li L, Hisamoto K, Kim KH, Haynes MP, Bauer PM, Sanjay A, Collinge M, Baron R, Sessa WC, Bender JR. Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16468-73.
    View in: PubMed
  47. Garcia T, Jackson A, Bachelier R, Clément-Lacroix P, Baron R, Clézardin P, Pujuguet P. A convenient clinically relevant model of human breast cancer bone metastasis. Clin Exp Metastasis. 2008; 25(1):33-42.
    View in: PubMed
  48. Gil-Henn H, Destaing O, Sims NA, Aoki K, Alles N, Neff L, Sanjay A, Bruzzaniti A, De Camilli P, Baron R, Schlessinger J. Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice. J Cell Biol. 2007 Sep 10; 178(6):1053-64.
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  49. Zhao Y, Bachelier R, Treilleux I, Pujuguet P, Peyruchaud O, Baron R, Clément-Lacroix P, Clézardin P. Tumor alphavbeta3 integrin is a therapeutic target for breast cancer bone metastases. Cancer Res. 2007 Jun 15; 67(12):5821-30.
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  50. Baron R, Rawadi G. Wnt signaling and the regulation of bone mass. Curr Osteoporos Rep. 2007 Jun; 5(2):73-80.
    View in: PubMed
  51. Bonaventure J, Gibbs L, Horne WC, Baron R. The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor. FEBS J. 2007 Jun; 274(12):3078-93.
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  52. Saito H, Kojima T, Takahashi M, Horne WC, Baron R, Amagasa T, Ohya K, Aoki K. A tumor necrosis factor receptor loop peptide mimic inhibits bone destruction to the same extent as anti-tumor necrosis factor monoclonal antibody in murine collagen-induced arthritis. Arthritis Rheum. 2007 Apr; 56(4):1164-74.
    View in: PubMed
  53. Baron R, Rawadi G. Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology. 2007 Jun; 148(6):2635-43.
    View in: PubMed
  54. Lin HS, Hu CY, Chan HY, Liew YY, Huang HP, Lepescheux L, Bastianelli E, Baron R, Rawadi G, Clément-Lacroix P. Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents. Br J Pharmacol. 2007 Apr; 150(7):862-72.
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  55. Wang L, Tassiulas I, Gil-Henn H, Schlessinger J, Baron R, Zhang J, Ivashkiv LB. Regulation of Macrophage Jak activation and STAT1 tyrosine phosphorylation by ITAM-associated receptors in mediated by calcium-dependent CaMK and Pyk2. Nature Immunology. 2007; 9:186-193.
  56. Sanjay A, Miyazaki T, Itzstein C, Purev E, Horne WC, Baron R. Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl. FEBS J. 2006 Dec; 273(23):5442-56.
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  57. Windahl SH, Galien R, Chiusaroli R, Clément-Lacroix P, Morvan F, Lepescheux L, Nique F, Horne WC, Resche-Rigon M, Baron R. Bone protection by estrens occurs through non-tissue-selective activation of the androgen receptor. J Clin Invest. 2006 Sep; 116(9):2500-9.
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  58. Koga F, Xu W, Karpova TS, McNally JG, Baron R, Neckers L. Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11318-22.
    View in: PubMed
  59. Morvan F, Boulukos K, Clément-Lacroix P, Roman Roman S, Suc-Royer I, Vayssière B, Ammann P, Martin P, Pinho S, Pognonec P, Mollat P, Niehrs C, Baron R, Rawadi G. Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res. 2006 Jun; 21(6):934-45.
    View in: PubMed
  60. Bruzzaniti A, Baron R. Molecular regulation of osteoclast activity. Rev Endocr Metab Disord. 2006 Jun; 7(1-2):123-39.
    View in: PubMed
  61. Aoki K, Saito H, Itzstein C, Ishiguro M, Shibata T, Blanque R, Mian AH, Takahashi M, Suzuki Y, Yoshimatsu M, Yamaguchi A, Deprez P, Mollat P, Murali R, Ohya K, Horne WC, Baron R. A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. J Clin Invest. 2006 Jun; 116(6):1525-34.
    View in: PubMed
  62. Baron R. FSH versus estrogen: who's guilty of breaking bones? Cell Metab. 2006 May; 3(5):302-5.
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  63. Suzuki Y, Aoki K, Saito H, Umeda M, Nitta H, Baron R, Ohya K. A tumor necrosis factor-alpha antagonist inhibits inflammatory bone resorption induced by Porphyromonas gingivalis infection in mice. J Periodontal Res. 2006 Apr; 41(2):81-91.
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  64. Marzia M, Chiusaroli R, Neff L, Kim NY, Chishti AH, Baron R, Horne WC. Calpain is required for normal osteoclast function and is down-regulated by calcitonin. J Biol Chem. 2006 Apr 7; 281(14):9745-54.
    View in: PubMed
  65. Koga F, Xu W, Karpova TS, McNally JG, Baron R, Neckers L. Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation. Proc. Nat. Acad. Sci. USA. 2006; 103:11318-11322.
  66. Baron R, Rawadi G, Roman-Roman S. Wnt signaling: a key regulator of bone mass. Curr Top Dev Biol. 2006; 76:103-27.
    View in: PubMed
  67. Miyazaki T, Tanaka S, Sanjay A, Baron R. The role of c-Src kinase in the regulation of osteoclast function. Mod Rheumatol. 2006; 16(2):68-74.
    View in: PubMed
  68. Horne WC, Sanjay A, Bruzzaniti A, Baron R. The role(s) of Src kinase and Cbl proteins in the regulation of osteoclast differentiation and function. Immunol Rev. 2005 Dec; 208:106-25.
    View in: PubMed
  69. Clément-Lacroix P, Ai M, Morvan F, Roman-Roman S, Vayssière B, Belleville C, Estrera K, Warman ML, Baron R, Rawadi G. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17406-11.
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  70. Rucci N, DiGiacinto C, Orrù L, Millimaggi D, Baron R, Teti A. A novel protein kinase C alpha-dependent signal to ERK1/2 activated by alphaVbeta3 integrin in osteoclasts and in Chinese hamster ovary (CHO) cells. J Cell Sci. 2005 Aug 1; 118(Pt 15):3263-75.
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  71. Bruzzaniti A, Neff L, Sanjay A, Horne WC, De Camilli P, Baron R. Dynamin forms a Src kinase-sensitive complex with Cbl and regulates podosomes and osteoclast activity. Mol Biol Cell. 2005 Jul; 16(7):3301-13.
    View in: PubMed
  72. Seck T, Pellegrini M, Florea AM, Grignoux V, Baron R, Mierke DF, Horne WC. The delta e13 isoform of the calcitonin receptor forms a six-transmembrane domain receptor with dominant-negative effects on receptor surface expression and signaling. Mol Endocrinol. 2005 Aug; 19(8):2132-44.
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  73. Jackson A, Vayssière B, Garcia T, Newell W, Baron R, Roman-Roman S, Rawadi G. Gene array analysis of Wnt-regulated genes in C3H10T1/2 cells. Bone. 2005 Apr; 36(4):585-98.
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  74. Kojima T, Aoki K, Nonaka K, Saito H, Azuma M, Iwai H, Varghese BJ, Yoshimasu H, Baron R, Ohya K, Amagasa T. Subcutaneous injections of a TNF-alpha antagonistic peptide inhibit both inflammation and bone resorption in collagen-induced murine arthritis. J Med Dent Sci. 2005 Mar; 52(1):91-9.
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  75. Hay E, Faucheu C, Suc-Royer I, Touitou R, Stiot V, Vayssière B, Baron R, Roman-Roman S, Rawadi G. Interaction between LRP5 and Frat1 mediates the activation of the Wnt canonical pathway. J Biol Chem. 2005 Apr 8; 280(14):13616-23.
    View in: PubMed
  76. Baron R, Horne WC. Regulation of osteoclast activity. Bone Resorption, F Bronner, MC Farach-Carson, J Rubin, Eds. 2005; 34-57.
  77. Ammann P, Bourrin S, Brunner F, Meyer JM, Clément-Lacroix P, Baron R, Gaillard M, Rizzoli R. A new selective estrogen receptor modulator HMR-3339 fully corrects bone alterations induced by ovariectomy in adult rats. Bone. 2004 Jul; 35(1):153-61.
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  78. Baron R. Arming the osteoclast. Nat Med. 2004 May; 10(5):458-60.
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  79. Kveiborg M, Sabatakos G, Chiusaroli R, Wu M, Philbrick WM, Horne WC, Baron R. DeltaFosB induces osteosclerosis and decreases adipogenesis by two independent cell-autonomous mechanisms. Mol Cell Biol. 2004 Apr; 24(7):2820-30.
    View in: PubMed
  80. Miyazaki T, Sanjay A, Neff L, Tanaka S, Horne WC, Baron R. Src kinase activity is essential for osteoclast function. J Biol Chem. 2004 Apr 23; 279(17):17660-6.
    View in: PubMed
  81. Zhou HM, Weskamp G, Chesneau V, Sahin U, Vortkamp A, Horiuchi K, Chiusaroli R, Hahn R, Wilkes D, Fisher P, Baron R, Manova K, Basson CT, Hempstead B, Blobel CP. Essential role for ADAM19 in cardiovascular morphogenesis. Mol Cell Biol. 2004 Jan; 24(1):96-104.
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  82. Baron R, Horne WC. The regulation of osteoclast activation. Topics in Bone Biology: Bone Resorption, Rubin J, Farach-Carson M, Bronner F, Eds. 2004.
  83. Longo M, Brama M, Marino M, Bernardini S, Korach KS, Wetsel WC, Scandurra R, Faraggiana T, Spera G, Baron R, Teti A, Migliaccio S. Interaction of estrogen receptor alpha with protein kinase C alpha and c-Src in osteoblasts during differentiation. Bone. 2004 Jan; 34(1):100-11.
    View in: PubMed
  84. Akiyama T, Bouillet P, Miyazaki T, Kadono Y, Chikuda H, Chung UI, Fukuda A, Hikita A, Seto H, Okada T, Inaba T, Sanjay A, Baron R, Kawaguchi H, Oda H, Nakamura K, Strasser A, Tanaka S. Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim. EMBO J. 2003 Dec 15; 22(24):6653-64.
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  85. Roman-Roman S, Shi DL, Stiot V, Haÿ E, Vayssière B, Garcia T, Baron R, Rawadi G. Murine Frizzled-1 behaves as an antagonist of the canonical Wnt/beta-catenin signaling. J Biol Chem. 2004 Feb 13; 279(7):5725-33.
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  86. Shin HI, Divieti P, Sims NA, Kobayashi T, Miao D, Karaplis AC, Baron R, Bringhurst R, Kronenberg HM. Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro. Endocrinology. 2004 Mar; 145(3):1376-85.
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  87. Chiusaroli R, Knobler H, Luxenburg C, Sanjay A, Granot-Attas S, Tiran Z, Miyazaki T, Harmelin A, Baron R, Elson A. Tyrosine phosphatase epsilon is a positive regulator of osteoclast function in vitro and in vivo. Mol Biol Cell. 2004 Jan; 15(1):234-44.
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  88. Rawadi G, Vayssière B, Dunn F, Baron R, Roman-Roman S. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res. 2003 Oct; 18(10):1842-53.
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  89. Chiusaroli R, Sanjay A, Henriksen K, Engsig MT, Horne WC, Gu H, Baron R. Deletion of the gene encoding c-Cbl alters the ability of osteoclasts to migrate, delaying resorption and ossification of cartilage during the development of long bones. Dev Biol. 2003 Sep 15; 261(2):537-47.
    View in: PubMed
  90. Chiusaroli R, Maier A, Knight MC, Byrne M, Calvi LM, Baron R, Krane SM, Schipani E. Collagenase cleavage of type I collagen is essential for both basal and parathyroid hormone (PTH)/PTH-related peptide receptor-induced osteoclast activation and has differential effects on discrete bone compartments. Endocrinology. 2003 Sep; 144(9):4106-16.
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  91. Horiuchi K, Weskamp G, Lum L, Hammes HP, Cai H, Brodie TA, Ludwig T, Chiusaroli R, Baron R, Preissner KT, Manova K, Blobel CP. Potential role for ADAM15 in pathological neovascularization in mice. Mol Cell Biol. 2003 Aug; 23(16):5614-24.
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  92. Sims NA, Clément-Lacroix P, Minet D, Fraslon-Vanhulle C, Gaillard-Kelly M, Resche-Rigon M, Baron R. A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice. J Clin Invest. 2003 May; 111(9):1319-27.
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  93. Roman-Roman S, Garcia T, Jackson A, Theilhaber J, Rawadi G, Connolly T, Spinella-Jaegle S, Kawai S, Courtois B, Bushnell S, Auberval M, Call K, Baron R. Identification of genes regulated during osteoblastic differentiation by genome-wide expression analysis of mouse calvaria primary osteoblasts in vitro. Bone. 2003 May; 32(5):474-82.
    View in: PubMed
  94. Seck T, Baron R, Horne WC. The alternatively spliced deltae13 transcript of the rabbit calcitonin receptor dimerizes with the C1a isoform and inhibits its surface expression. J Biol Chem. 2003 Jun 20; 278(25):23085-93.
    View in: PubMed
  95. Miyazaki T, Neff L, Tanaka S, Horne WC, Baron R. Regulation of cytochrome c oxidase activity by c-Src in osteoclasts. J Cell Biol. 2003 Mar 3; 160(5):709-18.
    View in: PubMed
  96. Seck T, Baron R, Horne WC. Binding of filamin to the C-terminal tail of the calcitonin receptor controls recycling. J Biol Chem. 2003 Mar 21; 278(12):10408-16.
    View in: PubMed
  97. Baron R. General principals of bone biology. Primer on the metabolic bone diseases and disorders of mineral metabolism, Favus M, Ed. 2003; 1-8.
  98. Haynes MP, Li L, Sinha D, Russell KS, Hisamoto K, Baron R, Collinge M, Sessa WC, Bender JR. Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen. J Biol Chem. 2003 Jan 24; 278(4):2118-23.
    View in: PubMed
  99. Kveiborg M, Chiusaroli R, Sims NA, Wu M, Sabatakos G, Horne WC, Baron R. The increased bone mass in deltaFosB transgenic mice is independent of circulating leptin levels. Endocrinology. 2002 Nov; 143(11):4304-9.
    View in: PubMed
  100. Mandine E, Jean-Baptiste V, Vayssière B, Gofflo D, Bénard D, Sarubbi E, Deprez P, Baron R, Superti-Furga G, Lesuisse D. High-affinity Src-SH2 ligands which do not activate Tyr(527)-phosphorylated Src in an experimental in vivo system. Biochem Biophys Res Commun. 2002 Oct 25; 298(2):185-92.
    View in: PubMed
  101. Zhang Z, Neff L, Bothwell AL, Baron R, Horne WC. Calcitonin induces dephosphorylation of Pyk2 and phosphorylation of focal adhesion kinase in osteoclasts. Bone. 2002 Sep; 31(3):359-65.
    View in: PubMed
  102. Baron R, Tsouderos Y. In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation. Eur J Pharmacol. 2002 Aug 16; 450(1):11-7.
    View in: PubMed
  103. Teti A, Migliaccio S, Baron R. The role of the alphaVbeta3 integrin in the development of osteolytic bone metastases: a pharmacological target for alternative therapy? Calcif Tissue Int. 2002 Oct; 71(4):293-9.
    View in: PubMed
  104. Garcia T, Roman-Roman S, Jackson A, Theilhaber J, Connolly T, Spinella-Jaegle S, Kawai S, Courtois B, Bushnell S, Auberval M, Call K, Baron R. Behavior of osteoblast, adipocyte, and myoblast markers in genome-wide expression analysis of mouse calvaria primary osteoblasts in vitro. Bone. 2002 Jul; 31(1):205-11.
    View in: PubMed
  105. Sims NA, Baron R. Bone: Structure, function, growth and remodeling. Orthopaedics, Firzgerald R, Kaufer H, Malkani AL, Eds. 2002; Section 2, Chapter 2:147-159.
  106. Duong LT, Sanjay A, Horne WC, Baron R, Rodan G. Integrin and calcitonin receptor signaling in the regulation of the cytoskeleton and function of the osteoclast. Principles of Bone Biology, Bilezikian J, Raisz L, Rodan G, Eds. 2002; Chapter 9:141-150.
  107. Bard F, Patel U, Levy JB, Jurdic P, Horne WC, Baron R. Molecular complexes that contain both c-Cbl and c-Src associate with Golgi membranes. Eur J Cell Biol. 2002 Jan; 81(1):26-35.
    View in: PubMed
  108. Sims NA, Dupont S, Krust A, Clement-Lacroix P, Minet D, Resche-Rigon M, Gaillard-Kelly M, Baron R. Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males. Bone. 2002 Jan; 30(1):18-25.
    View in: PubMed
  109. Theilhaber J, Connolly T, Roman-Roman S, Bushnell S, Jackson A, Call K, Garcia T, Baron R. Finding genes in the C2C12 osteogenic pathway by k-nearest-neighbor classification of expression data. Genome Res. 2002 Jan; 12(1):165-76.
    View in: PubMed
  110. Sims NA, Sabatakos G, Chen JS, Kelz MB, Nestler EJ, Baron R. Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass. Bone. 2002 Jan; 30(1):32-9.
    View in: PubMed
  111. Baron R, Sanjay A. The role of Src, Cbl and Pyk2 in vitronectin receptor-mediated adhesion in osteoclasts. Molecular Biology in Orthopaedics, Rosier RN, Evans CE, Eds. 2002; 221-228.
  112. Sanjay A, Horne WC, Baron R. The Cbl family: ubiquitin ligases regulating signaling by tyrosine kinases. Sci STKE. 2001 Nov 27; 2001(110):pe40.
    View in: PubMed
  113. Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GC, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Jüppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard MJ, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001 Nov 16; 107(4):513-23.
    View in: PubMed
  114. Rawadi G, Ferrer C, Spinella-Jaegle S, Roman-Roman S, Bouali Y, Baron R. 1-(5-oxohexyl)-3,7-Dimethylxanthine, a phosphodiesterase inhibitor, activates MAPK cascades and promotes osteoblast differentiation by a mechanism independent of PKA activation (pentoxifylline promotes osteoblast differentiation). Endocrinology. 2001 Nov; 142(11):4673-82.
    View in: PubMed
  115. Spinella-Jaegle S, Roman-Roman S, Faucheu C, Dunn FW, Kawai S, Galléa S, Stiot V, Blanchet AM, Courtois B, Baron R, Rawadi G. Opposite effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on osteoblast differentiation. Bone. 2001 Oct; 29(4):323-30.
    View in: PubMed
  116. Santhanagopal A, Chidiac P, Horne WC, Baron R, Dixon SJ. Calcitonin (CT) rapidly increases NA(+)/H(+) exchange and metabolic acid production: effects mediated selectively by the C1A CT receptor isoform. Endocrinology. 2001 Oct; 142(10):4401-13.
    View in: PubMed
  117. Peña CS, Saini S, Baron RL, Hamm BA, Morana G, Caudana R, Giovagnoni A, Villa A, Carriero A, Mathieu D, Bourne MW, Kirchin MA, Pirovano G, Spinazzi A. Detection of malignant primary hepatic neoplasms with gadobenate dimeglumine (Gd-BOPTA) enhanced T1-weighted hepatocyte phase MR imaging: results of off-site blinded review in a phase-II multicenter trial. Korean J Radiol. 2001 Oct-Dec; 2(4):210-5.
    View in: PubMed
  118. Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K, Tsuneoka M, Komiya S, Baron R, Yoshimura A. Spred is a Sprouty-related suppressor of Ras signalling. Nature. 2001 Aug 9; 412(6847):647-51.
    View in: PubMed
  119. Peyman A, Scheunemann K, Will DW, Knolle J, Wehner V, Breipohl G, Stilz HU, Carniato D, Ruxer J, Gourvest J, Auberval M, Doucet B, Baron R, Gaillard M, Gadek TR, Bodary S. alpha(v)beta(3) Antagonists based on a central thiophene scaffold. Bioorg Med Chem Lett. 2001 Aug 6; 11(15):2011-5.
    View in: PubMed
  120. Yokouchi M, Kondo T, Sanjay A, Houghton A, Yoshimura A, Komiya S, Zhang H, Baron R. Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins. J Biol Chem. 2001 Sep 14; 276(37):35185-93.
    View in: PubMed
  121. David JP, Rincon M, Neff L, Horne WC, Baron R. Carbonic anhydrase II is an AP-1 target gene in osteoclasts. J Cell Physiol. 2001 Jul; 188(1):89-97.
    View in: PubMed
  122. Spinella-Jaegle S, Rawadi G, Kawai S, Gallea S, Faucheu C, Mollat P, Courtois B, Bergaud B, Ramez V, Blanchet AM, Adelmant G, Baron R, Roman-Roman S. Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation. J Cell Sci. 2001 Jun; 114(Pt 11):2085-94.
    View in: PubMed
  123. Gallea S, Lallemand F, Atfi A, Rawadi G, Ramez V, Spinella-Jaegle S, Kawai S, Faucheu C, Huet L, Baron R, Roman-Roman S. Activation of mitogen-activated protein kinase cascades is involved in regulation of bone morphogenetic protein-2-induced osteoblast differentiation in pluripotent C2C12 cells. Bone. 2001 May; 28(5):491-8.
    View in: PubMed
  124. Rajapurohitam V, Chalhoub N, Benachenhou N, Neff L, Baron R, Vacher J. The mouse osteopetrotic grey-lethal mutation induces a defect in osteoclast maturation/function. Bone. 2001 May; 28(5):513-23.
    View in: PubMed
  125. Perez M, Migliaccio S, Taranta A, Festuccia C, Orrù L, Brama M, Bologna M, Faraggiana T, Baron R, Teti A. Melanoma cells stimulate osteoclastogenesis, c-Src expression and osteoblast cytokines. Eur J Cancer. 2001 Mar; 37(5):629-40.
    View in: PubMed
  126. Calvi LM, Sims NA, Hunzelman JL, Knight MC, Giovannetti A, Saxton JM, Kronenberg HM, Baron R, Schipani E. Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone. J Clin Invest. 2001 Feb; 107(3):277-86.
    View in: PubMed
  127. Sanjay A, Houghton A, Neff L, DiDomenico E, Bardelay C, Antoine E, Levy J, Gailit J, Bowtell D, Horne WC, Baron R. Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility. J Cell Biol. 2001 Jan 8; 152(1):181-95.
    View in: PubMed
  128. Violette SM, Guan W, Bartlett C, Smith JA, Bardelay C, Antoine E, Rickles RJ, Mandine E, van Schravendijk MR, Adams SE, Lynch BA, Shakespeare WC, Yang M, Jacobsen VA, Takeuchi CS, Macek KJ, Bohacek RS, Dalgarno DC, Weigele M, Lesuisse D, Sawyer TK, Baron R. Bone-targeted Src SH2 inhibitors block Src cellular activity and osteoclast-mediated resorption. Bone. 2001 Jan; 28(1):54-64.
    View in: PubMed
  129. Baron R. L'osteoclaste et les mecanismes moleculaires de la resorption osseuse. (Invited Review). Medecine et Sciences. 2001; 17:1260-1269.
  130. Zhang Z, Baron R, Horne WC. Integrin engagement, the actin cytoskeleton, and c-Src are required for the calcitonin-induced tyrosine phosphorylation of paxillin and HEF1, but not for calcitonin-induced Erk1/2 phosphorylation. J Biol Chem. 2000 Nov 24; 275(47):37219-23.
    View in: PubMed
  131. Sims NA, Clément-Lacroix P, Da Ponte F, Bouali Y, Binart N, Moriggl R, Goffin V, Coschigano K, Gaillard-Kelly M, Kopchick J, Baron R, Kelly PA. Bone homeostasis in growth hormone receptor-null mice is restored by IGF-I but independent of Stat5. J Clin Invest. 2000 Nov; 106(9):1095-103.
    View in: PubMed
  132. Amling M, Neff L, Priemel M, Schilling AF, Rueger JM, Baron R. Progressive increase in bone mass and development of odontomas in aging osteopetrotic c-src-deficient mice. Bone. 2000 Nov; 27(5):603-10.
    View in: PubMed
  133. Marzia M, Sims NA, Voit S, Migliaccio S, Taranta A, Bernardini S, Faraggiana T, Yoneda T, Mundy GR, Boyce BF, Baron R, Teti A. Decreased c-Src expression enhances osteoblast differentiation and bone formation. J Cell Biol. 2000 Oct 16; 151(2):311-20.
    View in: PubMed
  134. Sabatakos G, Sims NA, Chen J, Aoki K, Kelz MB, Amling M, Bouali Y, Mukhopadhyay K, Ford K, Nestler EJ, Baron R. Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis. Nat Med. 2000 Sep; 6(9):985-90.
    View in: PubMed
  135. Saini S, Sharma R, Baron RL, Turner DA, Ros PR, Hahn PF, Small WC, Delange EE, Stillman AE, Edelman RR, Runge VM, Outwater EK. Multicentre dose-ranging study on the efficacy of USPIO ferumoxtran-10 for liver MR imaging. Clin Radiol. 2000 Sep; 55(9):690-5.
    View in: PubMed
  136. Ochoa GC, Slepnev VI, Neff L, Ringstad N, Takei K, Daniell L, Kim W, Cao H, McNiven M, Baron R, De Camilli P. A functional link between dynamin and the actin cytoskeleton at podosomes. J Cell Biol. 2000 Jul 24; 150(2):377-89.
    View in: PubMed
  137. Kawai S, Faucheu C, Gallea S, Spinella-Jaegle S, Atfi A, Baron R, Roman SR. Mouse smad8 phosphorylation downstream of BMP receptors ALK-2, ALK-3, and ALK-6 induces its association with Smad4 and transcriptional activity. Biochem Biophys Res Commun. 2000 May 19; 271(3):682-7.
    View in: PubMed
  138. Delany AM, Amling M, Priemel M, Howe C, Baron R, Canalis E. Osteopenia and decreased bone formation in osteonectin-deficient mice J Clin Invest. 2000 May; 105(9):1325.
    View in: PubMed
  139. Violette SM, Shakespeare WC, Bartlett C, Guan W, Smith JA, Rickles RJ, Bohacek RS, Holt DA, Baron R, Sawyer TK. A Src SH2 selective binding compound inhibits osteoclast-mediated resorption. Chem Biol. 2000 Mar; 7(3):225-35.
    View in: PubMed
  140. Delaissé JM, Engsig MT, Everts V, del Carmen Ovejero M, Ferreras M, Lund L, Vu TH, Werb Z, Winding B, Lochter A, Karsdal MA, Troen T, Kirkegaard T, Lenhard T, Heegaard AM, Neff L, Baron R, Foged NT. Proteinases in bone resorption: obvious and less obvious roles. Clin Chim Acta. 2000 Feb 15; 291(2):223-34.
    View in: PubMed
  141. Townsend PA, Villanova I, Uhlmann E, Peyman A, Knolle J, Baron R, Teti A, Horton MA. An antisense oligonucleotide targeting the alphaV integrin gene inhibits adhesion and induces apoptosis in breast cancer cells. Eur J Cancer. 2000 Feb; 36(3):397-409.
    View in: PubMed
  142. Yokouchi M, Baron R, Yoshimura A. RING connection between ubiquitination and tumorigenesis. Experimental Medicine. 2000; 18:464-467.
  143. Sims NA, Baron R. Bone Cells and their Functions. Skeletal Growth Factors, E Canalis, Editor. 2000; Chpter 1:1-16.
  144. Riggs BL, Baron R, Boyle WJ, Drezner M, Manolagas S, Martin TJ, Stewart AF, Suda T, Yasuda H, Aubin J, Goltzman D. Proposed standard nomenclature for new tumor necrosis factor members involved in the regulation of bone resorption. Bone. 2000; 67:761-764.
  145. Villanova I, Townsend PA, Uhlmann E, Knolle J, Peyman A, Amling M, Baron R, Horton MA, Teti A. Oligodeoxynucleotide targeted to the alphav gene inhibits alphav integrin synthesis, impairs osteoclast function, and activates intracellular signals to apoptosis. J Bone Miner Res. 1999 Nov; 14(11):1867-79.
    View in: PubMed
  146. Amling M, Priemel M, Holzmann T, Chapin K, Rueger JM, Baron R, Demay MB. Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses. Endocrinology. 1999 Nov; 140(11):4982-7.
    View in: PubMed
  147. Hernando N, David P, Tarsio M, Bartkiewicz M, Horne WC, Kane PM, Baron R. The presence of the alternatively spliced A2 cassette in the vacuolar H+-ATPase subunit A prevents assembly of the V1 catalytic domain. Eur J Biochem. 1999 Nov; 266(1):293-301.
    View in: PubMed
  148. Yokouchi M, Kondo T, Houghton A, Bartkiewicz M, Horne WC, Zhang H, Yoshimura A, Baron R. Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J Biol Chem. 1999 Oct 29; 274(44):31707-12.
    View in: PubMed
  149. Bartkiewicz M, Houghton A, Baron R. Leucine zipper-mediated homodimerization of the adaptor protein c-Cbl. A role in c-Cbl's tyrosine phosphorylation and its association with epidermal growth factor receptor. J Biol Chem. 1999 Oct 22; 274(43):30887-95.
    View in: PubMed
  150. Aoki K, Didomenico E, Sims NA, Mukhopadhyay K, Neff L, Houghton A, Amling M, Levy JB, Horne WC, Baron R. The tyrosine phosphatase SHP-1 is a negative regulator of osteoclastogenesis and osteoclast resorbing activity: increased resorption and osteopenia in me(v)/me(v) mutant mice. Bone. 1999 Sep; 25(3):261-7.
    View in: PubMed
  151. Zhang Z, Hernandez-Lagunas L, Horne WC, Baron R. Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase. J Biol Chem. 1999 Aug 27; 274(35):25093-8.
    View in: PubMed
  152. Schecroun N, Pidoux E, Horne WC, Hernandez-Lagunas L, Baron R, Cressent M. Biological properties of salmon calcitonin IV. J Bone Miner Res. 1999 Aug; 14(8):1425-31.
    View in: PubMed
  153. Lanske B, Amling M, Neff L, Guiducci J, Baron R, Kronenberg HM. Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development. J Clin Invest. 1999 Aug; 104(4):399-407.
    View in: PubMed
  154. Shyu JF, Zhang Z, Hernandez-Lagunas L, Camerino C, Chen Y, Inoue D, Baron R, Horne WC. Protein kinase C antagonizes pertussis-toxin-sensitive coupling of the calcitonin receptor to adenylyl cyclase. Eur J Biochem. 1999 May; 262(1):95-101.
    View in: PubMed
  155. Inoue D, Shih C, Galson DL, Goldring SR, Horne WC, Baron R. Calcitonin-dependent down-regulation of the mouse C1a calcitonin receptor in cells of the osteoclast lineage involves a transcriptional mechanism. Endocrinology. 1999 Mar; 140(3):1060-8.
    View in: PubMed
  156. Clément-Lacroix P, Ormandy C, Lepescheux L, Ammann P, Damotte D, Goffin V, Bouchard B, Amling M, Gaillard-Kelly M, Binart N, Baron R, Kelly PA. Osteoblasts are a new target for prolactin: analysis of bone formation in prolactin receptor knockout mice. Endocrinology. 1999 Jan; 140(1):96-105.
    View in: PubMed
  157. Corral DA, Amling M, Priemel M, Loyer E, Fuchs S, Ducy P, Baron R, Karsenty G. Dissociation between bone resorption and bone formation in osteopenic transgenic mice. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13835-40.
    View in: PubMed
  158. David JP, Neff L, Chen Y, Rincon M, Horne WC, Baron R. A new method to isolate large numbers of rabbit osteoclasts and osteoclast-like cells: application to the characterization of serum response element binding proteins during osteoclast differentiation. J Bone Miner Res. 1998 Nov; 13(11):1730-8.
    View in: PubMed
  159. Li YC, Amling M, Pirro AE, Priemel M, Meuse J, Baron R, Delling G, Demay MB. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology. 1998 Oct; 139(10):4391-6.
    View in: PubMed
  160. Chen Y, Shyu JF, Santhanagopal A, Inoue D, David JP, Dixon SJ, Horne WC, Baron R. The calcitonin receptor stimulates Shc tyrosine phosphorylation and Erk1/2 activation. Involvement of Gi, protein kinase C, and calcium. J Biol Chem. 1998 Jul 31; 273(31):19809-16.
    View in: PubMed
  161. Kelly KA, Tanaka S, Baron R, Gimble JM. Murine bone marrow stromally derived BMS2 adipocytes support differentiation and function of osteoclast-like cells in vitro. Endocrinology. 1998 Apr; 139(4):2092-101.
    View in: PubMed
  162. Inoue D, Reid M, Lum L, Krätzschmar J, Weskamp G, Myung YM, Baron R, Blobel CP. Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells. J Biol Chem. 1998 Feb 13; 273(7):4180-7.
    View in: PubMed
  163. Insogna KL, Sahni M, Grey AB, Tanaka S, Horne WC, Neff L, Mitnick M, Levy JB, Baron R. Colony-stimulating factor-1 induces cytoskeletal reorganization and c-src-dependent tyrosine phosphorylation of selected cellular proteins in rodent osteoclasts. J Clin Invest. 1997 Nov 15; 100(10):2476-85.
    View in: PubMed
  164. Inoue D, Santiago P, Horne WC, Baron R. Identification of an osteoclast transcription factor that binds to the human T cell leukemia virus type I-long terminal repeat enhancer element. J Biol Chem. 1997 Oct 3; 272(40):25386-93.
    View in: PubMed
  165. Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R, Demay MB. Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc Natl Acad Sci U S A. 1997 Sep 2; 94(18):9831-5.
    View in: PubMed
  166. Billecocq A, Horne WC, Chakraborty M, Takeyasu K, Levenson R, Baron R. 1,25-Dihydroxyvitamin D3 selectively induces increased expression of the Na,K-ATPase beta 1 subunit in avian myelomonocytic cells without a concomitant change in Na,K-ATPase activity. J Cell Physiol. 1997 Aug; 172(2):221-9.
    View in: PubMed
  167. Amling M, Neff L, Tanaka S, Inoue D, Kuida K, Weir E, Philbrick WM, Broadus AE, Baron R. Bcl-2 lies downstream of parathyroid hormone-related peptide in a signaling pathway that regulates chondrocyte maturation during skeletal development. J Cell Biol. 1997 Jan 13; 136(1):205-13.
    View in: PubMed
  168. Insogna K, Tanaka S, Neff L, Horne W, Levy J, Baron R. Role of c-Src in cellular events associated with colony-stimulating factor-1-induced spreading in osteoclasts. Mol Reprod Dev. 1997 Jan; 46(1):104-8.
    View in: PubMed
  169. Sahni M, Zhou XM, Bakiri L, Schlessinger J, Baron R, Levy JB. Identification of a novel 135-kDa Grb2-binding protein in osteoclasts. J Biol Chem. 1996 Dec 20; 271(51):33141-7.
    View in: PubMed
  170. Shyu JF, Inoue D, Baron R, Horne WC. The deletion of 14 amino acids in the seventh transmembrane domain of a naturally occurring calcitonin receptor isoform alters ligand binding and selectively abolishes coupling to phospholipase C. J Biol Chem. 1996 Dec 6; 271(49):31127-34.
    View in: PubMed
  171. Baron R. Molecular mechanisms of bone resorption: therapeutic implications. Rev Rhum Engl Ed. 1996 Nov; 63(10):633-8.
    View in: PubMed
  172. Tanaka S, Amling M, Neff L, Peyman A, Uhlmann E, Levy JB, Baron R. c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption. Nature. 1996 Oct 10; 383(6600):528-31.
    View in: PubMed
  173. David P, Nguyen H, Barbier A, Baron R. The bisphosphonate tiludronate is a potent inhibitor of the osteoclast vacuolar H(+)-ATPase. J Bone Miner Res. 1996 Oct; 11(10):1498-507.
    View in: PubMed
  174. Weir EC, Philbrick WM, Amling M, Neff LA, Baron R, Broadus AE. Targeted overexpression of parathyroid hormone-related peptide in chondrocytes causes chondrodysplasia and delayed endochondral bone formation. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10240-5.
    View in: PubMed
  175. David P, Horne WC, Baron R. Vanadate inhibits vacuolar H(+)-ATPase-mediated proton transport in chicken kidney microsomes by an ADP-dependent mechanism. Biochim Biophys Acta. 1996 Apr 3; 1280(1):155-60.
    View in: PubMed
  176. Levy JB, Schindler C, Raz R, Levy DE, Baron R, Horowitz MC. Activation of the JAK-STAT signal transduction pathway by oncostatin-M cultured human and mouse osteoblastic cells. Endocrinology. 1996 Apr; 137(4):1159-65.
    View in: PubMed
  177. Tanaka S, Levy JB, Insogna KL. Baron R. c-Src: An essential gene for osteoclast function. Osteoporosis Japan. 1996; 4:62-67.
  178. Baron R. Molecular mechanisms of bone resorption. An update. Acta Orthop Scand Suppl. 1995 Oct; 266:66-70.
    View in: PubMed
  179. Bartkiewicz M, Hernando N, Reddy SV, Roodman GD, Baron R. Characterization of the osteoclast vacuolar H(+)-ATPase B-subunit. Gene. 1995 Jul 28; 160(2):157-64.
    View in: PubMed
  180. Hernando N, Bartkiewicz M, Collin-Osdoby P, Osdoby P, Baron R. Alternative splicing generates a second isoform of the catalytic A subunit of the vacuolar H(+)-ATPase. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):6087-91.
    View in: PubMed
  181. Tanaka S, Neff L, Baron R, Levy JB. Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways. J Biol Chem. 1995 Jun 16; 270(24):14347-51.
    View in: PubMed
  182. Ravesloot JH, Eisen T, Baron R, Boron WF. Role of Na-H exchangers and vacuolar H+ pumps in intracellular pH regulation in neonatal rat osteoclasts. J Gen Physiol. 1995 Feb; 105(2):177-208.
    View in: PubMed
  183. David P, Baron R. The vacuolar H+ATPase: A potential target for drug development in bone diseases. Expert Opinion on Invest. Drugs. 1995; 4:725-740.
  184. Baron R,. Anatomy and ultrastructure of bone. Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. 1995; 3-9.
  185. Baron R, Bartkiewicz M, David P Hernando-Sobrino N. Acidification and Bone Resorption: The Role and Characteristics of V-ATPases in the Osteoclast. Organellar Proton ATPases, Nelson N, Ed., Molecular biology Intelligence Series. 1995; 49-74.
  186. David P, Baron R. The catalytic cycle of the vacuolar H(+)-ATPase. Comparison of proton transport in kidney- and osteoclast-derived vesicles. J Biol Chem. 1994 Dec 2; 269(48):30158-63.
    View in: PubMed
  187. Chakraborty M, Chatterjee D, Gorelick FS, Baron R. Cell cycle-dependent and kinase-specific regulation of the apical Na/H exchanger and the Na,K-ATPase in the kidney cell line LLC-PK1 by calcitonin. Proc Natl Acad Sci U S A. 1994 Mar 15; 91(6):2115-9.
    View in: PubMed
  188. Baron R. The cellular basis of bone resorption: Cell biology of the osteoclast. Bone Formation and Repair, CT Brighton, GE Friedlaender, JM Lane, Eds. 1994; 247-252.
  189. Horowitz MC, Jay PR, Quian H-Y, baron R, Levy JB. Cytokine-induced signl transduction mediated by nonreceptor-tyrosine kinases in bone cells. Bone Formation and Repair, CT Brighton, GE Friedlaender, JM Lane, Eds. 1994; 269-278.
  190. Friedlaender GE, Troiano N, Ishii M, Pelker RR, Baron R. Abnormal bone remodeling: The consequences of the therapeutic drugs and physical modalities. Bone Formation and Repair, CT Brighton, GE Friedlaender, JM Lane, Eds. 1994; 289-297.
  191. Horne WC, Shyu JF, Chakraborty M, Baron R. Signal transduction by calcitonin: Multiple ligands, receptors and signaling pathways. Trends in Endocrinology. 1994; 5:395-401.
  192. Baron R, Bartkiewicz M, Chatterjee D, Chakrabort M, David P, Fabricant C, Hernando N. Characterization of the osteoclast vacuolar ATPase: Biochemistry, subunit composition and cloning of catalytic subunits. Molecular and Cellular Mechanisms of H+ Transport, NATO ASI Cell Biology Series, BH Hirst, Ed. 1994; 89:145-151.
  193. Weir EC, Horowitz MC, Baron R, Centrella M, Kacinski BM, Insogna KL. Macrophage colony-stimulating factor release and receptor expression in bone cells. J Bone Miner Res. 1993 Dec; 8(12):1507-18.
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  194. Delaissé JM, Eeckhout Y, Neff L, François-Gillet C, Henriet P, Su Y, Vaes G, Baron R. (Pro)collagenase (matrix metalloproteinase-1) is present in rodent osteoclasts and in the underlying bone-resorbing compartment. J Cell Sci. 1993 Dec; 106 ( Pt 4):1071-82.
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  195. Ruddle NH, Li CB, Horne WC, Santiago P, Troiano N, Jay G, Horowitz M, Baron R. Mice transgenic for HTLV-I LTR-tax exhibit tax expression in bone, skeletal alterations, and high bone turnover. Virology. 1993 Nov; 197(1):196-204.
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  196. Chatterjee D, Neff L, Chakraborty M, Fabricant C, Baron R. Sensitivity to nitrate and other oxyanions further distinguishes the vanadate-sensitive osteoclast proton pump from other vacuolar H(+)-ATPases. Biochemistry. 1993 Mar 23; 32(11):2808-12.
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  197. Horne WC, Levy JB, Baron R. Proto-oncogenes and osteoclast function. Italian J. of Min. and Electrolyte Metab. 1993; 7:185-197.
  198. Baron R. The molecular mechanisms of bone resorption. Proceedings of the 24th International Conf. on Osteoporosis, C Christiansen, B Riis, Eds. 1993; 258-260.
  199. Baron R, Chakraborty M, Chatterjee D, Horne WC, Lomri , Ravesloot J-H. Biology of the Osteoclast. Handbook of Experimental Pharmacology, Vol 107: Physiology and Pharmacology of Bone, GR Mundy, TJ Martin, Eds. 1993; Vol 107(Chapter 3):111-147.
  200. Baron R, Ravesloot J-H, Neff L, Chakraborty M, Chatterjee D, Lomri A, Horne WC. Cellular and Molecular Biology of the osteoclast. Cellular and Molecular Biology of Bone, M Noda, Ed. 1993; 446-495.
  201. Baron R, . Molecular Mechanisms and Regulation of Bone Resorption. Progress in Endocrinology, Mornex R, Jaffiol C, Lecleare J, Eds. 1993; 375-381.
  202. Horne WC, Neff L, Chatterjee D, Lomri A, Levy JB, Baron R. Osteoclasts express high levels of pp60c-src in association with intracellular membranes. J Cell Biol. 1992 Nov; 119(4):1003-13.
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  203. Chatterjee D, Chakraborty M, Leit M, Neff L, Jamsa-Kellokumpu S, Fuchs R, Bartkiewicz M, Hernando N, Baron R. The osteoclast proton pump differs in its pharmacology and catalytic subunits from other vacuolar H(+)-ATPases. J Exp Biol. 1992 Nov; 172:193-204.
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  204. Su Y, Chakraborty M, Nathanson MH, Baron R. Differential effects of the 3',5'-cyclic adenosine monophosphate and protein kinase C pathways on the response of isolated rat osteoclasts to calcitonin. Endocrinology. 1992 Sep; 131(3):1497-502.
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  205. Chatterjee D, Chakraborty M, Leit M, Neff L, Jamsa-Kellokumpu S, Fuchs R, Baron R. Sensitivity to vanadate and isoforms of subunits A and B distinguish the osteoclast proton pump from other vacuolar H+ ATPases. Proc Natl Acad Sci U S A. 1992 Jul 15; 89(14):6257-61.
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  206. Lomri A, Baron R. 1 alpha,25-dihydroxyvitamin D3 regulates the transcription of carbonic anhydrase II mRNA in avian myelomonocytes. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4688-92.
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  207. Prallet B, Male P, Neff L, Baron R. Identification of a functional mononuclear precursor of the osteoclast in chicken medullary bone marrow cultures. J Bone Miner Res. 1992 Apr; 7(4):405-14.
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  208. Delaisse JM, Neff L, Eeckhout Y, Su Y, Vaes G, Baron R. Evidence for the presence of (ro) collagenase in osteoclasts. Calcium Regulation and Bone Metabolism, Cohn DV, Gennari C, Tashjian AH, Eds. 1992; 161-164.
  209. Baron R, Bartkiewicz M, Chakraborty M, Chatterjee D, Fabricant C, Hernando N, Horne WC, Lomri A, Neff L, Ravesloot JH, Su Y. Ion transport and the molecular mechanisms of bone resorption. Calcium Regulation and Bone Metabolism, Cohn DV, Gennari C, Tashjian AH, Eds. 1992; 131-141.
  210. Prallet B, Alexandre C, Baron R. [In vitro identification of a mononuclear precursor of osteoclast]. Rev Rhum Mal Osteoartic. 1991 Nov 30; 58(11):777-80.
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  211. Chakraborty M, Chatterjee D, Kellokumpu S, Rasmussen H, Baron R. Cell cycle-dependent coupling of the calcitonin receptor to different G proteins. Science. 1991 Mar 1; 251(4997):1078-82.
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  212. Baron R, Neff L, Brown W, Louvard D, Courtoy PJ. Selective internalization of the apical plasma membrane and rapid redistribution of lysosomal enzymes and mannose 6-phosphate receptors during osteoclast inactivation by calcitonin. J Cell Sci. 1990 Nov; 97 ( Pt 3):439-47.
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  213. Billecocq A, Emanuel JR, Levenson R, Baron R. 1 alpha,25-dihydroxyvitamin D3 regulates the expression of carbonic anhydrase II in nonerythroid avian bone marrow cells. Proc Natl Acad Sci U S A. 1990 Aug; 87(16):6470-4.
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  214. Lindsey AE, Schneider K, Simmons DM, Baron R, Lee BS, Kopito RR. Functional expression and subcellular localization of an anion exchanger cloned from choroid plexus. Proc Natl Acad Sci U S A. 1990 Jul; 87(14):5278-82.
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  215. Billecocq A. Rettig-Emanuel J, Levenson R, Baron R. l alpha,25-Dihydroxyvitamin D3 regulates the expression of carbonic anhydrase II n nonerythroid avain bone marrow cells. Proc. nat. Acad. Sci. USA. 1990; 87:6470-6474.
  216. Prallet B, Male P, Neff L, Billecocq A, Baron R. late mononuclear osteoclast precursors resorb bone in vitro. Calcium Regulation and Bone Metabolism, DV Cohn, FH Glorieux, TJ Martin, Eds. 1990; 434-438.
  217. Chen C, Carpenter T, Steg N, Baron R, Anast C. Hypercalciuric hypophosphatemic rickets, mineral balance, bone histomorphometry, and therapeutic implications of hypercalciuria. Pediatrics. 1989 Aug; 84(2):276-80.
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  218. Baron R. Molecular mechanisms of bone resorption by the osteoclast. Anat Rec. 1989 Jun; 224(2):317-24.
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  219. Baron R, Prallet B. Les Bases Cellulaires de l'Homeostasie du Squelette. Medicine and Hygiene. 1989; 47:825-828.
  220. Baron R. Polarity and membrane transport in osteoclasts. Connect Tissue Res. 1989; 20(1-4):109-20.
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  221. Thomas HA, Machen TE, Smolka A, Baron R, Kopito RR. Anion exchanger-related peptides and (H,K)ATPase are present on opposite membranes of the same gastric mucosal oxntic cells. Am J Physiol. 1989; 257:C537-C544.
  222. Kellokumpu S, Neff L, Jämsä-Kellokumpu S, Kopito R, Baron R. A 115-kD polypeptide immunologically related to erythrocyte band 3 is present in Golgi membranes. Science. 1988 Dec 2; 242(4883):1308-11.
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  223. Rubin KR, Ballow M, Baron R, Greenstein RM, Raisz LG, Rowe DW. Malignant osteoporosis and defective immunoregulation. J Bone Miner Res. 1988 Oct; 3(5):509-16.
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  224. Baron R, Neff L, Brown W, Courtoy PJ, Louvard D, Farquhar MG. Polarized secretion of lysosomal enzymes: co-distribution of cation-independent mannose-6-phosphate receptors and lysosomal enzymes along the osteoclast exocytic pathway. J Cell Biol. 1988 Jun; 106(6):1863-72.
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  225. Key LL, Volberg F, Baron R, Anast CS. Treatment of craniometaphyseal dysplasia with calcitriol. J Pediatr. 1988 Apr; 112(4):583-7.
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  226. de Vernejoul MC, Horowitz M, Demignon J, Neff L, Baron R. Bone resorption by isolated chick osteoclasts in culture is stimulated by murine spleen cell supernatant fluids (osteoclast-activating factor) and inhibited by calcitonin and prostaglandin E2. J Bone Miner Res. 1988 Feb; 3(1):69-80.
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  227. Jaeger P, Jones W, Kashgarian M, Baron R, Clemens TL, Segre GV, Hayslett JP. Animal model of primary hyperparathyroidism. Am J Physiol. 1987 Jun; 252(6 Pt 1):E790-8.
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  228. Dyess CL, Carter D, Kirchner JA, Baron RE. A morphometric comparison of the changes in the laryngeal skeleton associated with invasion by tumor and by external-beam radiation. Cancer. 1987 Mar 15; 59(6):1117-22.
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  229. Marie P, Alexandre C, Chappard D, Berthel M, Jensen P, Baron R, Caulin F. Postmenopausal osteoporosis treated with phosphate and intermittent calcitonin. Osteoporosis, C. Christiansen, JS Johansen, BJ Riss, Eds. 1987; 936-941.
  230. Marie P, Alexandre C, Chappard D, Berthel M, Jensen P, Lange R, Baron R, Caulin F. Rationale of using sequential treatment with phosphate and calcitonin in postmenopausal osteoporosis. Calcium Regulation and Bone Metabolism: Basic and Clinical Aspects, Cohn DV, Martin TJ, Meunier PJ, Eds. 1987; 943-947.
  231. De Luca J, Cianelli C, Friedlaender GE, Baron R. A comparative histomorphometric study of bone remodeling in human paired cancellous allografts and autografts. Trans. Orthop. Res. Soc. 1987; 12:356.
  232. Baron R, Neff L, Roy C, Boisvert A, Caplan M. Evidence for a high and specific concentration of (Na+,K+)ATPase in the plasma membrane of the osteoclast. Cell. 1986 Jul 18; 46(2):311-20.
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  233. Baron R, Neff L, Tran Van P, Nefussi JR, Vignery A. Kinetic and cytochemical identification of osteoclast precursors and their differentiation into multinucleated osteoclasts. Am J Pathol. 1986 Feb; 122(2):363-78.
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  234. Baron R. [The cellular base of adult bone remodelling]. Orthod Fr. 1986; 57 Pt 2:371-7.
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  235. Baron R, Neff L, Louvard D, Courtoy PJ. Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border. J Cell Biol. 1985 Dec; 101(6):2210-22.
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  236. Nefussi JR, Baron R. PGE2 stimulates both resorption and formation of bone in vitro: differential responses of the periosteum and the endosteum in fetal rat long bone cultures. Anat Rec. 1985 Jan; 211(1):9-16.
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  237. Horowitz M, Baron R, Mart J, Andreoli M, Vignery A. Osteoclast Activating Factor is distinct from the monokine Interleukin-1. Br. J. Rheumatol. 1985; 24(suppl 1):162-164.
  238. Gkonos PJ, Hayes T, Burtis W, Jacoby R, McGuire J, Baron R, Stewart AF. Squamous carcinoma model of humoral hypercalcemia of malignancy. Endocrinology. 1984 Dec; 115(6):2384-90.
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  239. Godsall JW, Baron R, Insogna KL. Vitamin D metabolism and bone histomorphometry in a patient with antacid-induced osteomalacia. Am J Med. 1984 Oct; 77(4):747-50.
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  240. Horowitz M, Vignery A, Gershon RK, Baron R. Thymus-derived lymphocytes and their interactions with macrophages are required for the production of osteoclast-activating factor in the mouse. Proc Natl Acad Sci U S A. 1984 Apr; 81(7):2181-5.
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  241. Friedlaender GE, Tross RB, Doganis AC, Kirkwood JM, Baron R. Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model. J Bone Joint Surg Am. 1984 Apr; 66(4):602-7.
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  242. Insogna KL, Stewart AF, Vignery AM, Weir EC, Namnum PA, Baron RE, Kirkwood JM, Deftos LM, Broadus AE. Biochemical and histomorphometric characterization of a rat model for humoral hypercalcemia of malignancy. Endocrinology. 1984 Mar; 114(3):888-96.
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  243. Baron R, Tross R, Vignery A. Evidence of sequential remodeling in rat trabecular bone: morphology, dynamic histomorphometry, and changes during skeletal maturation. Anat Rec. 1984 Jan; 208(1):137-45.
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  244. Friedlander GE, Baron R, Pelker RR, Doganis AC. The effects of chemotherapy and radiation therapy on physiologic bone turnover and fracture repair. Soft and Hard Tissue, TK Hunt, RB Heppenstall, E Pines, D Rovee, Eds. 1984; 397-416.
  245. Baron R, Vignery A, Horowitz M. Lymphocytes, macrophages and the regulation of bone remodeling. Advances in Bone and Mineral Research, Annual, HWA Peck, Ed. 1984; 175-243.
  246. Guedon C, de Vernejoul MC, Gehanno P, Baron R, Soussaline M. [Biological aspects of bone grafts and vascularized bone transfer]. Ann Chir Plast Esthet. 1984; 29(4):322-8.
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  247. Jaeger P, Jones W, Baron R, Hayslett JP. Modulation of hypercalcemia by dichloromethane diphosphonate and by calcitonin in a model of chronic primary hyperparathyroidism in rats. Prog Clin Biol Res. 1984; 168:375-80.
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  248. Baron R, Mage S, Silverglate A, Broadus A, Lang R. Estimation of trabecular bone resorption by histomorpometry: Evidence for a prolonged reversal phase with normal resorption in post-menopausal osteoporosis and coupled increased resorption in primary hyperparathyroidism. Clinical Disorders of Bone and Mineral Metabolism, Frame B and Potts J, Eds. 1984; 191-195.
  249. Broadus AE, Magee JS, Mallette LE, Horst RL, Lang R, Jensen PS, Gertner JM, Baron R. A detailed evaluation of oral phosphate therapy in selected patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 1983 May; 56(5):953-61.
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  250. Simmons DJ, Russell JE, Winter F, Tran Van P, Vignery A, Baron R, Rosenberg GD, Walker WV. Effect of spaceflight on the non-weight-bearing bones of rat skeleton. Am J Physiol. 1983 Mar; 244(3):R319-26.
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  251. Baron R, Gertner JM, Lang R, Vignery A. Increased bone turnover with decreased bone formation by osteoblasts in children with osteogenesis imperfecta tarda. Pediatr Res. 1983 Mar; 17(3):204-7.
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  252. Baron R, Vignery A, Neff L, Silverglate A, Santa Maria A. Processing of undecalcified bone specimens for bone histomorphometry. Bone Histomorphometry: Techniques and Interpretation, R.R. Recker Ed. 1983; 13-35.
  253. Friedlaender GE, Baron R, Pelker RR. Effects of Chemotherapy on Bone. Osteochondrial Allografts. Biology, Banking and Clinical Applications, Friedlaender, GE, Mankin HJ, Sell KW, Eds. 1983; 319-327.
  254. Nefussi JR, Vignery A, Puzas JE, Baron R. Histomorphometry and autoradiography of cultured fetal rat long bones. Anat Rec. 1982 Oct; 204(2):105-12.
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  255. Stewart AF, Vignery A, Silverglate A, Ravin ND, LiVolsi V, Broadus AE, Baron R. Quantitative bone histomorphometry in humoral hypercalcemia of malignancy: uncoupling of bone cell activity. J Clin Endocrinol Metab. 1982 Aug; 55(2):219-27.
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  256. Tran Van PT, Vignery A, Baron R. Cellular kinetics of the bone remodeling sequence in the rat. Anat Rec. 1982 Apr; 202(4):445-51.
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  257. Tran Van P, Vignery A, Baron R. An electron-microscopic study of the bone-remodeling sequence in the rat. Cell Tissue Res. 1982; 225(2):283-92.
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  258. Baron R, Mazur A, Norman M. Histomorphometric classification of juvenile renal osteodystrophy: Prevalence of a mineralization defect. Vitamin D, A.W. Norman et al, Eds. 1982; 853-855.
  259. Baron R, Tran Van P, Vignery A. Local control of bone remodeling: A suggested role for receptor-mediated endocytosis. Current Advances in Skeletogenesis, M. Silbermann and H. Slavkin, Eds. 1982; 123-127.
  260. Rasmussen H, Mazur A, Pechet M, Gertner J, Baron R, Anast C. Treatment of familial hypophosphatemic rickets. Vitamin D, A.W. Norman et al, Eds. 1982; 1219-1225.
  261. Langman C B, Mazur A T, Baron R, Norman M E. 25-hydroxyvitamin D3 (calcifediol) therapy of juvenile renal osteodystrophy: Beneficial effect on linear growth velocity. J. Peds. 1982; 100:815-820.
  262. Baron R, Vignery A. Behavior of the osteoclasts during a rapid change in their number induced by high doses of parathyroid hormone or calcitonin in intact rats. . Metab. Bone Dis. Rel. Res. 1981; 2:339-346.
  263. Simmons DJ, Russell JE, Winter F, Baron R, Vignery A, Tran VT, Rosenberg GD, Walker W. Bone growth in the rat mandible during space flight. Physiologist. 1980 Dec; 23(Suppl 6):S87-90.
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  264. Rasmussen H, Baron R, Broadus A, DeFronzo R, Lang R, Horst R. 1,25(OH)2D3 is not the only D metabolite involved in the pathogenesis of osteomalacia. Am J Med. 1980 Sep; 69(3):360-8.
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  265. Norman ME, Mazur AT, Borden S, Gruskin A, Anast C, Baron R, Rasmussen H. Early diagnosis of juvenile renal osteodystrophy. J Pediatr. 1980 Aug; 97(2):226-32.
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  266. Vignery A, Baron R. Dynamic histomorphometry of alveolar bone remodeling in the adult rat. Anat Rec. 1980 Feb; 196(2):191-200.
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  267. Jensen PS, Orphanoudakis SC, Rauschkolb EN, Baron R, Lang R, Rasmussen H. Assessment of bone mass in the radius by computed tomography. AJR Am J Roentgenol. 1980 Feb; 134(2):285-92.
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  268. Delling G, Luehmann M, Baron R, Mathews CHE, Olah A. Investigation of intra-and inter-reader reproducibility. Bone Histomorphometry, A.M. Parfitt and W.S.S. Jee, Eds. Suppl. to Metab. Bone Dis. Rel. Res. 1980; 2S:419-427.
  269. Baron R, Vignery A, Lang R. Reversal phase and osteoporosis: Defective coupling of resorption to formationn of pathogenesis of osteoporosis. Osteoporosis: Recent Advances in Pathogenesis and Treatment, H.F. DeLuca, Ed. 1980; 311-320.
  270. Canalis E, Reardon G E, Baron R, Raisz L G. Dynamic bone morphometry and studies on the effects of serum on bone metabolism in vitro in a case of pycnodysostosis. Metab. Bone Dis. Rel. Res. 1980; 2:99-106.
  271. Baron R, Vignery A, Tran Van P. The significance of lacunar erosion without osteoclasts: Studies on the reversal phase of the remodeling sequence. Bone Histomorphometry, A.M. Parfitt, W.S.S. Jee, Eds., Suppl. to Metab. Bone Dis. Res. 1980; 2S:35-40.
  272. Baron R, Vignery A, Lang R, LiVolsi V, Broadus A. Reversal lacunae and resporption-formation coupling: A histomorphometric comparison between osteopenia and hyperparathyroidism. Osteoporosis, H. Rasmussen, Ed. 1980; 141-149.
  273. Vignery A, Baron R. Comparative effects of APD and C12MDP on bone in the rat: In vivo and In vitro studies. Bone Histomorphometry, A.M. Parfitt and W.S.S. Jee Eds., Suppl. to Metab. Bone Dis. Rel. Res. 1980; 2S:381-387.
  274. Baron R, Norman M, Mazur A, Gruskin A, Rasmussen H. Bone histomorphometry in children with early chronic renal failure treated with 25(OH)D3. Vitamin D, Basic Research and Its Clinical Application, AW Norman, K Schaefer, DV Herrath, HG Grigoleit, JW Coburn, HF DeLuca, EB Mauer, T Suda, Eds. 1979; 847-850.
  275. Baron R, Gertner J, Lang R, Vignery A . Dynamic histomorphometry of trabecular bone in children with osteogenesis imperfecta. Trans. Orthop. Res. Soc. 1979; 4:107.
  276. Tross R B, Friedlaender G E, Baron R, Panjabi M. The effect of chemotherapy on bone volume and strength. Trans. Orthop. Res. Soc. 1979; 4:262.
  277. Vignery A, Baron R. Effects of parathyroid hormone on the osteoclastic pool, bone resorption and formation in rat alveolar bone. Calcif Tissue Res. 1978 Nov 10; 26(1):23-8.
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  278. Baron R, Saffar JL. A quantitative study of bone remodeling during experimental periodontal disease in the golden hamster. J Periodontal Res. 1978 Jul; 13(4):309-15.
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  279. Saffar JL, Baron R. A quantitative study of osteoclastic bone resorption during experimental periodontal disease in the golden hamster. J Periodontal Res. 1977 Sep; 12(5):387-94.
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  280. Baron R, Saffar JL, Duflot-Vignery A. Alveolar bone remodelling in the rat: normal status and effects of PTX and PTH on the remodelling sequence and the osteoclastic pool. Calcif Tissue Res. 1977 May; 22 Suppl:502-4.
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  281. Baron R, Saffar JL. A quantitative study of the effects of prolonged calcitonin treatment on alveolar bone remodelling in the golden hamster. Calcif Tissue Res. 1977 Feb 11; 22(3):265-74.
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  282. Baron R. [Changes in alveolar bone during spontaneous and induced tooth movement]. Mondo Ortod. 1977 Feb-Mar; 19(1):29-44.
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  283. Baron R. Importance of the intermediate phases between resorption and formation in the measurement and understanding of the bone remodeling sequence. Bone Histomorphometry, P.J. Meunier, Ed. 1977; 1977.
  284. Baron R. Osteogenese et fonction osteoblastique dans le maintien de la masse osseuse. Entretiens de Bichat. Odonto-Stomatologie, L'Expansion Scientifique, Ed. 1976; 27-32.
  285. Baron R, Saffar J-L, Kaleka R. Etude histometrique des effects de la calcitonine sur la pathologies observee au cours des parodontopathies experimentales chez le hamster dore. L'Information Dentaire. 1976; 48:103-112.
  286. Baron R, Vignery A. Changes in the osteoclastic pools and the osteoclasts nuclei balance after a single injection of salmon calcitonin in the adult rat. Bone Histomorphometry, P.J. Meunier, Ed. 1976; 147-156.
  287. Baron R. [Remodeling of alveolar bone in spontaneous and induced tooth displacement]. Rev Orthop Dento Faciale. 1975 Jul; 9(3):309-25.
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  288. Mailland M, Baron R. [Quantitative study of the effects of occlusal overload on interradicular bone density in the rat]. J Biol Buccale. 1975 Mar; 3(1):41-51.
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  289. Baron R. [Changes in alveolar bone in spontaneous or completed dental movement]. Inf Orthod Kieferorthop. 1975; 7(3):241-59.
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  290. Baron R. Histophysiologie des reactions tissulaires au cours du deplacement orthodontique. Bases Fondamentales de l'ODF, M Chateau, Ed. 1975; 328-364.
  291. Drouet J, Deloince R, Baron R. Etude ultrastructurale de la reaction periostee au cours des fractures diaphysaires chez des souris exposees a une irradiation X. Medecine et Armees. 1974; 2:427-436.
  292. Baron R. Histologie et physiologie de al lame cribriforme. Entretiens de Bichat. Ondonto-Stomatologie, L'Expansion Scientifique Ed. 1973; 7-15.
  293. Baron R. Ultrastructure de l'os fascicule et des fibres de Sharpey de la lame cribriforme. J. Biol. Buccale. 1973; 1:201-213.
  294. Deloince R, Baron R, Drouet J. Ultrastructure de la reaction periostee apres fracture chez la souris. I. Les differents type cellulaires. Bull. Ann. CRSSA. 1973; 103-105.
  295. Baron R. Analyse de la conservation des vestiges dentaires dans les sepultures collectives. L'Homme, Hier et Aujourd'hui. Receuil d'etudes en Hommage a Andre Leroi-Gourhan. 1973; 295-305.
  296. Drouet J, Baron R, Deloince R. Ultrastructure de la reaction periostee apres fracture chez la souris. II. Formation et mineralisation du tissue osteoide. Bull. Ann. CRSSA. 1973; 106-108.
  297. Drouet J, Baron R, Deloince R. Etude ultrastructurale des effects d'une irradiation sur la reaction periostee apres fracture chez la souris. Bull. Ann. CRSSA. 1973; 43-45.
  298. Markostamou K, Baron R. [Quantitative study of osteoclasia of the alveolar ridge in experimental orthodontics in rats]. Orthod Fr. 1973; 44(1):245-58.
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  299. Baron R. Remaniement de la lame cribriforme et des fibres desmodontales au cours de la migration physiologique. J. Biol. Buccale. 1973; 1:151-171.
  300. Baron R., Le Jeune M, Klapisz-Wolikow M. Aspects miscroscopiques des surfaces d'usure et mouvements mandibulaires. Etude prelimninaire sur quelques mammiferes. Sci. Rech. Odontostom. 1972; 2:25-31.
  301. Baron R, Mailland M, Lai Son OH. Les transplantations sous-cutanees de germes dentaires dans le cadre de l'etude de l'os alveolaire. ConreAngle. 1972; 2:7576.
  302. Lai HO, Baron R, Mailland M. [Statistical study of the incidence of dental caries and missing teeth in some neolithic populations of the Paris basin]. Rev Fr Odontostomatol. 1970 Oct; 17(8):1063-80.
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  303. Juster M, Hess JC, Baron R. [Microradiography and dentistry]. Rev Fr Odontostomatol. 1970 Aug-Sep; 17(7):917-26.
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  304. Baron R, Balmain-Oligo N. [The cribriform lamina in the rat. A microradiographic and historical survey]. Actual Odontostomatol (Paris). 1970 Jun; 90:183-98.
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  305. Baron R. Etude odontologique de la population neolithique des incinerations de Neuvy-en-Dunois. Gallia Prehistoire (CNRS) XI. 1968; 224-231.
  306. Baron R, Monimignaut C. Etude odontologique de la population neolithique de la epulture collective de marolles sur Seine. Gallia Prehistoire (CNRS) X. 1967; 141-155.
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