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Stuart K. Calderwood, Ph.D.

TitleAssociate Professor of Radiation Oncology
InstitutionBeth Israel Deaconess Medical Center
DepartmentRadiation Oncology
AddressBeth Israel Deaconess Med Ctr
Radiation Oncology
330 Brookline Ave
Boston MA 02215

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hara ES, Ono M, Eguchi T, Kubota S, Pham HT, Sonoyama W, Tajima S, Takigawa M, Calderwood SK, Kuboki T. miRNA-720 Controls Stem Cell Phenotype, Proliferation and Differentiation of Human Dental Pulp Cells. PLoS One. 2013; 8(12):e83545.
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  2. Calderwood SK. From stress protein biochemistry to novel immunotherapeutics. Int J Hyperthermia. 2013 Aug; 29(5):362-3.
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  3. Weng D, Song B, Koido S, Calderwood SK, Gong J. Immunotherapy of radioresistant mammary tumors with early metastasis using molecular chaperone vaccines combined with ionizing radiation. J Immunol. 2013 Jul 15; 191(2):755-63.
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  4. Murshid A, Eguchi T, Calderwood SK. Stress proteins in aging and life span. Int J Hyperthermia. 2013 Aug; 29(5):442-7.
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  5. Calderwood SK, Gong J, Stevenson MA, Murshid A. Cellular and molecular chaperone fusion vaccines: Targeting resistant cancer cell populations. Int J Hyperthermia. 2013 Aug; 29(5):376-9.
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  6. Calderwood SK. Molecular cochaperones: tumor growth and cancer treatment. Scientifica (Cairo). 2013; 2013:217513.
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  7. Eguchi T, Watanabe K, Hara ES, Ono M, Kuboki T, Calderwood SK. OstemiR: A Novel Panel of MicroRNA Biomarkers in Osteoblastic and Osteocytic Differentiation from Mesencymal Stem Cells. PLoS One. 2013; 8(3):e58796.
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  8. Calderwood SK. Tumor heterogeneity, clonal evolution, and therapy resistance: an opportunity for multitargeting therapy. Discov Med. 2013 Mar; 15(82):188-94.
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  9. Murshid A, Gong J, Calderwood SK. Purification, preparation, and use of chaperone-Peptide complexes for tumor immunotherapy. Methods Mol Biol. 2013; 960:209-17.
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  10. Calderwood SK. HSF1, A Versatile Factor in Tumorogenesis. Curr Mol Med. 2012 Nov 1; 12(9):1102-7.
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  11. Calderwood SK, Stevenson MA, Murshid A. Heat shock proteins, autoimmunity, and cancer treatment. Autoimmune Dis. 2012; 2012:486069.
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  12. Ciocca DR, Arrigo AP, Calderwood SK. Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update. Arch Toxicol. 2013 Jan; 87(1):19-48.
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  13. Chou SD, Prince T, Gong J, Calderwood SK. mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis. PLoS One. 2012; 7(6):e39679.
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  14. Calderwood SK, Murshid A, Gong J. Heat shock proteins: conditional mediators of inflammation in tumor immunity. Front Immunol. 2012; 3:75.
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  15. Calderwood SK, Gong J. Molecular chaperones in mammary cancer growth and breast tumor therapy. J Cell Biochem. 2012 Apr; 113(4):1096-103.
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  16. Calderwood SK. Elevated levels of HSF1 indicate a poor prognosis in breast cancer. Future Oncol. 2012 Apr; 8(4):399-401.
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  17. Murshid A, Gong J, Calderwood SK. The role of heat shock proteins in antigen cross presentation. Front Immunol. 2012; 3:63.
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  18. Weng D, Penzner JH, Song B, Koido S, Calderwood SK, Gong J. Metastasis is an early event in mouse mammary carcinomas and is associated with cells bearing stem cell markers. Breast Cancer Res. 2012; 14(1):R18.
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  19. Zhang Y, Murshid A, Prince T, Calderwood SK. Protein kinase A regulates molecular chaperone transcription and protein aggregation. PLoS One. 2011; 6(12):e28950.
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  20. Ogawa K, Kim HK, Shimizu T, Abe S, Shiga Y, Calderwood SK. Plasma heat shock protein 72 as a biomarker of sarcopenia in elderly people. Cell Stress Chaperones. 2012 May; 17(3):349-59.
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  21. Murshid A, Gong J, Stevenson MA, Calderwood SK. Heat shock proteins and cancer vaccines: developments in the past decade and chaperoning in the decade to come. Expert Rev Vaccines. 2011 Nov; 10(11):1553-68.
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  22. Weng D, Song B, Durfee J, Sugiyama V, Wu Z, Koido S, Calderwood SK, Gong J. Induction of cytotoxic T lymphocytes against ovarian cancer-initiating cells. Int J Cancer. 2011 Oct 15; 129(8):1990-2001.
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  23. Zhang Y, Chou SD, Murshid A, Prince TL, Schreiner S, Stevenson MA, Calderwood SK. The role of heat shock factors in stress-induced transcription. Methods Mol Biol. 2011; 787:21-32.
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  24. Zhang Y, Calderwood SK. Autophagy, protein aggregation and hyperthermia: a mini-review. Int J Hyperthermia. 2011; 27(5):409-14.
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  25. Ogawa K, Seta R, Shimizu T, Shinkai S, Calderwood SK, Nakazato K, Takahashi K. Plasma adenosine triphosphate and heat shock protein 72 concentrations after aerobic and eccentric exercise. Exerc Immunol Rev. 2011; 17:136-49.
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  26. Weng D, Calderwood SK, Gong J. Preparation of a heat-shock protein 70-based vaccine from DC-tumor fusion cells. Methods Mol Biol. 2011; 787:255-65.
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  27. Murshid A, Theriault J, Gong J, Calderwood SK. Investigating receptors for extracellular heat shock proteins. Methods Mol Biol. 2011; 787:289-302.
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  28. Murshid A, Chou SD, Prince T, Zhang Y, Bharti A, Calderwood SK. Protein kinase A binds and activates heat shock factor 1. PLoS One. 2010; 5(11):e13830.
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  29. Weng D, Cunin MC, Song B, Price BD, Eller MS, Gilchrest BA, Calderwood SK, Gong J. Radiosensitization of mammary carcinoma cells by telomere homolog oligonucleotide pretreatment. Breast Cancer Res. 2010; 12(5):R71.
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  30. Murshid A, Gong J, Calderwood SK. Heat shock protein 90 mediates efficient antigen cross presentation through the scavenger receptor expressed by endothelial cells-I. J Immunol. 2010 Sep 1; 185(5):2903-17.
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  31. Henderson B, Calderwood SK, Coates AR, Cohen I, van Eden W, Lehner T, Pockley AG. Caught with their PAMPs down? The extracellular signalling actions of molecular chaperones are not due to microbial contaminants. Cell Stress Chaperones. 2010 Mar; 15(2):123-41.
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  32. Calderwood SK. Heat shock proteins in breast cancer progression--a suitable case for treatment? Int J Hyperthermia. 2010; 26(7):681-5.
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  33. Gong J, Zhang Y, Durfee J, Weng D, Liu C, Koido S, Song B, Apostolopoulos V, Calderwood SK. A heat shock protein 70-based vaccine with enhanced immunogenicity for clinical use. J Immunol. 2010 Jan 1; 184(1):488-96.
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  34. Adachi M, Liu Y, Fujii K, Calderwood SK, Nakai A, Imai K, Shinomura Y. Oxidative stress impairs the heat stress response and delays unfolded protein recovery. PLoS One. 2009; 4(11):e7719.
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  35. Kottke T, Pulido J, Thompson J, Sanchez-Perez L, Chong H, Calderwood SK, Selby P, Harrington K, Strome SE, Melcher A, Vile RG. Antitumor immunity can be uncoupled from autoimmunity following heat shock protein 70-mediated inflammatory killing of normal pancreas. Cancer Res. 2009 Oct 1; 69(19):7767-74.
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  36. Jaskelioff M, Song W, Xia J, Liu C, Kramer J, Koido S, Gendler SJ, Calderwood SK, Gong J. Telomerase deficiency and telomere dysfunction inhibit mammary tumors induced by polyomavirus middle T oncogene. Oncogene. 2009 Dec 3; 28(48):4225-36.
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  37. Gong J, Zhu B, Murshid A, Adachi H, Song B, Lee A, Liu C, Calderwood SK. T cell activation by heat shock protein 70 vaccine requires TLR signaling and scavenger receptor expressed by endothelial cells-1. J Immunol. 2009 Sep 1; 183(5):3092-8.
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  38. Calderwood SK, Murshid A, Prince T. The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-review. Gerontology. 2009; 55(5):550-8.
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  39. Li GC, Calderwood SK. Hyperthermia classic article commentary: 'Re-induction of hsp70 synthesis: an assay for thermotolerance' by Gloria C. Li and Johnson Y. Mak, International Journal of Hyperthermia 1989;5:389-403. Int J Hyperthermia. 2009 Jun; 25(4):258-61.
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  40. Pockley AG, Calderwood SK, Multhoff G. The atheroprotective properties of Hsp70: a role for Hsp70-endothelial interactions? Cell Stress Chaperones. 2009 Nov; 14(6):545-53.
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  41. Gong J, Koido S, Calderwood SK. Cell fusion: from hybridoma to dendritic cell-based vaccine. Expert Rev Vaccines. 2008 Sep; 7(7):1055-68.
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  42. Murshid A, Gong J, Calderwood SK. Heat-shock proteins in cancer vaccines: agents of antigen cross-presentation. Expert Rev Vaccines. 2008 Sep; 7(7):1019-30.
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  43. Gray PJ, Prince T, Cheng J, Stevenson MA, Calderwood SK. Targeting the oncogene and kinome chaperone CDC37. Nat Rev Cancer. 2008 Jul; 8(7):491-5.
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  44. Calderwood SK, Ciocca DR. Heat shock proteins: stress proteins with Janus-like properties in cancer. Int J Hyperthermia. 2008 Feb; 24(1):31-9.
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  45. Park MA, Yacoub A, Rahmani M, Zhang G, Hart L, Hagan MP, Calderwood SK, Sherman MY, Koumenis C, Spiegel S, Chen CS, Graf M, Curiel DT, Fisher PB, Grant S, Dent P. OSU-03012 stimulates PKR-like endoplasmic reticulum-dependent increases in 70-kDa heat shock protein expression, attenuating its lethal actions in transformed cells. Mol Pharmacol. 2008 Apr; 73(4):1168-84.
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  46. Pockley AG, Muthana M, Calderwood SK. The dual immunoregulatory roles of stress proteins. Trends Biochem Sci. 2008 Feb; 33(2):71-9.
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  47. Calderwood SK, Gong J, Theriault JR, Mambula SS, Gray PJ. Cell stress proteins: novel immunotherapeutics. Novartis Found Symp. 2008; 291:115-31; discussion 131-40.
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  48. Gray PJ, Stevenson MA, Calderwood SK. Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells. Cancer Res. 2007 Dec 15; 67(24):11942-50.
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  49. Kottke T, Sanchez-Perez L, Diaz RM, Thompson J, Chong H, Harrington K, Calderwood SK, Pulido J, Georgopoulos N, Selby P, Melcher A, Vile R. Induction of hsp70-mediated Th17 autoimmunity can be exploited as immunotherapy for metastatic prostate cancer. Cancer Res. 2007 Dec 15; 67(24):11970-9.
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  50. Calderwood SK, Theriault J, Gray PJ, Gong J. Cell surface receptors for molecular chaperones. Methods. 2007 Nov; 43(3):199-206.
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  51. Mambula SS, Stevenson MA, Ogawa K, Calderwood SK. Mechanisms for Hsp70 secretion: crossing membranes without a leader. Methods. 2007 Nov; 43(3):168-75.
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  52. Khaleque MA, Bharti A, Gong J, Gray PJ, Sachdev V, Ciocca DR, Stati A, Fanelli M, Calderwood SK. Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1. Oncogene. 2008 Mar 20; 27(13):1886-93.
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  53. Calderwood SK, Mambula SS, Gray PJ. Extracellular heat shock proteins in cell signaling and immunity. Ann N Y Acad Sci. 2007 Oct; 1113:28-39.
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  54. Tang D, Kang R, Xiao W, Wang H, Calderwood SK, Xiao X. The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages. J Immunol. 2007 Jul 15; 179(2):1236-44.
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  55. Calderwood SK, Mambula SS, Gray PJ, Theriault JR. Extracellular heat shock proteins in cell signaling. FEBS Lett. 2007 Jul 31; 581(19):3689-94.
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  56. Asea AA, Milani V, Calderwood SK. Heat shock proteins in physiology and pathology: the Berlin meeting. Cell Stress Chaperones. 2007; 12(3):205-8.
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  57. Thériault JR, Adachi H, Calderwood SK. Role of scavenger receptors in the binding and internalization of heat shock protein 70. J Immunol. 2006 Dec 15; 177(12):8604-11.
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  58. Mambula SS, Calderwood SK. Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes. J Immunol. 2006 Dec 1; 177(11):7849-57.
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  59. Enomoto Y, Bharti A, Khaleque AA, Song B, Liu C, Apostolopoulos V, Xing PX, Calderwood SK, Gong J. Enhanced immunogenicity of heat shock protein 70 peptide complexes from dendritic cell-tumor fusion cells. J Immunol. 2006 Nov 1; 177(9):5946-55.
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  60. Mambula SS, Calderwood SK. Heat induced release of Hsp70 from prostate carcinoma cells involves both active secretion and passive release from necrotic cells. Int J Hyperthermia. 2006 Nov; 22(7):575-85.
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  61. Ciocca DR, Gago FE, Fanelli MA, Calderwood SK. Co-expression of steroid receptors (estrogen receptor alpha and/or progesterone receptors) and Her-2/neu: Clinical implications. J Steroid Biochem Mol Biol. 2006 Dec; 102(1-5):32-40.
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  62. Shi Y, Tu Z, Tang D, Zhang H, Liu M, Wang K, Calderwood SK, Xiao X. The inhibition of LPS-induced production of inflammatory cytokines by HSP70 involves inactivation of the NF-kappaB pathway but not the MAPK pathways. Shock. 2006 Sep; 26(3):277-84.
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  63. Calderwood SK, Khaleque MA, Sawyer DB, Ciocca DR. Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci. 2006 Mar; 31(3):164-72.
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  64. Zaarur N, Gabai VL, Porco JA, Calderwood S, Sherman MY. Targeting heat shock response to sensitize cancer cells to proteasome and Hsp90 inhibitors. Cancer Res. 2006 Feb 1; 66(3):1783-91.
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  65. Calderwood SK, Theriault JR, Gong J. How is the immune response affected by hyperthermia and heat shock proteins? Int J Hyperthermia. 2005 Dec; 21(8):713-6.
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  66. Wang X, Khaleque MA, Zhao MJ, Zhong R, Gaestel M, Calderwood SK. Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. J Biol Chem. 2006 Jan 13; 281(2):782-91.
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  67. Khaleque MA, Bharti A, Sawyer D, Gong J, Benjamin IJ, Stevenson MA, Calderwood SK. Induction of heat shock proteins by heregulin beta1 leads to protection from apoptosis and anchorage-independent growth. Oncogene. 2005 Sep 29; 24(43):6564-73.
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  68. Calderwood SK, Theriault JR, Gong J. Message in a bottle: role of the 70-kDa heat shock protein family in anti-tumor immunity. Eur J Immunol. 2005 Sep; 35(9):2518-27.
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  69. Calderwood SK. Evolving connections between molecular chaperones and neuronal function. Int J Hyperthermia. 2005 Aug; 21(5):375-8.
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  70. Tonkiss J, Calderwood SK. Regulation of heat shock gene transcription in neuronal cells. Int J Hyperthermia. 2005 Aug; 21(5):433-44.
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  71. Thériault JR, Mambula SS, Sawamura T, Stevenson MA, Calderwood SK. Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells. FEBS Lett. 2005 Mar 28; 579(9):1951-60.
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  72. Calderwood SK. Chaperones and slow death--a recipe for tumor immunotherapy. Trends Biotechnol. 2005 Feb; 23(2):57-9.
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  73. Peng X, Guo X, Borkan SC, Bharti A, Kuramochi Y, Calderwood S, Sawyer DB. Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. J Biol Chem. 2005 Apr 1; 280(13):13148-52.
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  74. Tang D, Khaleque MA, Jones EL, Theriault JR, Li C, Wong WH, Stevenson MA, Calderwood SK. Expression of heat shock proteins and heat shock protein messenger ribonucleic acid in human prostate carcinoma in vitro and in tumors in vivo. Cell Stress Chaperones. 2005; 10(1):46-58.
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  75. Ciocca DR, Calderwood SK. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones. 2005; 10(2):86-103.
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  76. Calderwood SK. Regulatory interfaces between the stress protein response and other gene expression programs in the cell. Methods. 2005 Feb; 35(2):139-48.
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  77. Jones EL, Zhao MJ, Stevenson MA, Calderwood SK. The 70 kilodalton heat shock protein is an inhibitor of apoptosis in prostate cancer. Int J Hyperthermia. 2004 Dec; 20(8):835-49.
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  78. Wang X, Grammatikakis N, Siganou A, Stevenson MA, Calderwood SK. Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress. J Biol Chem. 2004 Nov 19; 279(47):49460-9.
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  79. Tanaka Y, Koido S, Xia J, Ohana M, Liu C, Cote GM, Sawyer DB, Calderwood S, Gong J. Development of antigen-specific CD8+ CTL in MHC class I-deficient mice through CD4 to CD8 conversion. J Immunol. 2004 Jun 15; 172(12):7848-58.
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  80. Wang Y, Theriault JR, He H, Gong J, Calderwood SK. Expression of a dominant negative heat shock factor-1 construct inhibits aneuploidy in prostate carcinoma cells. J Biol Chem. 2004 Jul 30; 279(31):32651-9.
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  81. Wang X, Grammatikakis N, Siganou A, Calderwood SK. Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. Mol Cell Biol. 2003 Sep; 23(17):6013-26.
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  82. He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, Brown SA, Kingston RE, Calderwood SK. Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. J Biol Chem. 2003 Sep 12; 278(37):35465-75.
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  83. Soncin F, Zhang X, Chu B, Wang X, Asea A, Ann Stevenson M, Sacks DB, Calderwood SK. Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2. Biochem Biophys Res Commun. 2003 Apr 4; 303(2):700-6.
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  84. Xie Y, Zhong R, Chen C, Calderwood SK. Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes. J Biol Chem. 2003 Feb 14; 278(7):4687-98.
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  85. Noessner E, Gastpar R, Milani V, Brandl A, Hutzler PJ, Kuppner MC, Roos M, Kremmer E, Asea A, Calderwood SK, Issels RD. Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells. J Immunol. 2002 Nov 15; 169(10):5424-32.
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  86. Calderwood SK, Asea A. Targeting HSP70-induced thermotolerance for design of thermal sensitizers. Int J Hyperthermia. 2002 Nov-Dec; 18(6):597-608.
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  87. Zhao M, Tang D, Lechpammer S, Hoffman A, Asea A, Stevenson MA, Calderwood SK. Double-stranded RNA-dependent protein kinase (pkr) is essential for thermotolerance, accumulation of HSP70, and stabilization of ARE-containing HSP70 mRNA during stress. J Biol Chem. 2002 Nov 15; 277(46):44539-47.
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  88. Lechpammer S, Asea A, Mallick R, Zhong R, Sherman MY, Calderwood SK. Development of an XTT tetrazolium salt-based assay for detection of specific hyperthermia sensitizers in a high-flux screening programme. Int J Hyperthermia. 2002 May-Jun; 18(3):203-15.
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  89. Xie Y, Chen C, Stevenson MA, Hume DA, Auron PE, Calderwood SK. NF-IL6 and HSF1 have mutually antagonistic effects on transcription in monocytic cells. Biochem Biophys Res Commun. 2002 Mar 8; 291(4):1071-80.
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  90. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, Calderwood SK. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem. 2002 Apr 26; 277(17):15028-34.
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  91. Xie Y, Chen C, Stevenson MA, Auron PE, Calderwood SK. Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6. J Biol Chem. 2002 Apr 5; 277(14):11802-10.
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  92. Singh IS, He JR, Calderwood S, Hasday JD. A high affinity HSF-1 binding site in the 5'-untranslated region of the murine tumor necrosis factor-alpha gene is a transcriptional repressor. J Biol Chem. 2002 Feb 15; 277(7):4981-8.
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  93. Asea A, Mallick R, Lechpammer S, Ara G, Teicher BA, Fiorentino S, Stevenson MA, Calderwood SK. Cyclooxygenase inhibitors are potent sensitizers of prostate tumours to hyperthermia and radiation. Int J Hyperthermia. 2001 Sep-Oct; 17(5):401-14.
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  94. Asea A, Ara G, Teicher BA, Stevenson MA, Calderwood SK. Effects of the flavonoid drug quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo. Int J Hyperthermia. 2001 Jul-Aug; 17(4):347-56.
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  95. Ehmann UK, Calderwood SK, Stevenson MA. Gap-junctional communication between feeder cells and recipient normal epithelial cells correlates with growth stimulation. In Vitro Cell Dev Biol Anim. 2001 Feb; 37(2):100-10.
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  96. Tang D, Xie Y, Zhao M, Stevenson MA, Calderwood SK. Repression of the HSP70B promoter by NFIL6, Ku70, and MAPK involves three complementary mechanisms. Biochem Biophys Res Commun. 2001 Jan 12; 280(1):280-5.
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  97. Soncin F, Asea A, Zhang X, Stevenson MA, Calderwood SK. Role of calcium activated kinases and phosphatases in heat shock factor-1 activation. Int J Mol Med. 2000 Dec; 6(6):705-10.
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  98. Asea A, Kabingu E, Stevenson MA, Calderwood SK. HSP70 peptidembearing and peptide-negative preparations act as chaperokines. Cell Stress Chaperones. 2000 Nov; 5(5):425-31.
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  99. He H, Chen C, Xie Y, Asea A, Calderwood SK. HSP70 and heat shock factor 1 cooperate to repress Ras-induced transcriptional activation of the c-fos gene. Cell Stress Chaperones. 2000 Nov; 5(5):406-11.
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  100. Wang X, Asea A, Xie Y, Kabingu E, Stevenson MA, Calderwood SK. RSK2 represses HSF1 activation during heat shock. Cell Stress Chaperones. 2000 Nov; 5(5):432-7.
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  101. Hecker KH, Asea A, Kobayashi K, Green S, Tang D, Calderwood SK. Mutation detection in the human HSP7OB' gene by denaturing high-performance liquid chromatography. Cell Stress Chaperones. 2000 Nov; 5(5):415-24.
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  102. Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC, Calderwood SK. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med. 2000 Apr; 6(4):435-42.
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  103. Singh IS, Viscardi RM, Kalvakolanu I, Calderwood S, Hasday JD. Inhibition of tumor necrosis factor-alpha transcription in macrophages exposed to febrile range temperature. A possible role for heat shock factor-1 as a negative transcriptional regulator. J Biol Chem. 2000 Mar 31; 275(13):9841-8.
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  104. Palayoor ST, Youmell MY, Calderwood SK, Coleman CN, Price BD. Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 2; 18(51):7389-94.
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  105. Stevenson MA, Zhao MJ, Asea A, Coleman CN, Calderwood SK. Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes. J Immunol. 1999 Nov 15; 163(10):5608-16.
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  106. Housby JN, Cahill CM, Chu B, Prevelige R, Bickford K, Stevenson MA, Calderwood SK. Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May; 11(5):347-58.
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  107. Bruce JL, Chen C, Xie Y, Zhong R, Wang YQ, Stevenson MA, Calderwood SK. Activation of heat shock transcription factor 1 to a DNA binding form during the G(1)phase of the cell cycle. Cell Stress Chaperones. 1999 Mar; 4(1):36-45.
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  108. Xie Y, Cahill CM, Asea A, Auron PE, Calderwood SK. Heat shock proteins and regulation of cytokine expression. Infect Dis Obstet Gynecol. 1999; 7(1-2):26-30.
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  109. Ehmann UK, Stevenson MA, Calderwood SK, DeVries JT. Physical connections between feeder cells and recipient normal mammary epithelial cells. Exp Cell Res. 1998 Aug 25; 243(1):76-86.
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  110. Chu B, Zhong R, Soncin F, Stevenson MA, Calderwood SK. Transcriptional activity of heat shock factor 1 at 37 degrees C is repressed through phosphorylation on two distinct serine residues by glycogen synthase kinase 3 and protein kinases Calpha and Czeta. J Biol Chem. 1998 Jul 17; 273(29):18640-6.
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  111. Palayoor ST, Bump EA, Calderwood SK, Bartol S, Coleman CN. Combined antitumor effect of radiation and ibuprofen in human prostate carcinoma cells. Clin Cancer Res. 1998 Mar; 4(3):763-71.
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  112. Chen C, Xie Y, Stevenson MA, Auron PE, Calderwood SK. Heat shock factor 1 represses Ras-induced transcriptional activation of the c-fos gene. J Biol Chem. 1997 Oct 24; 272(43):26803-6.
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  113. Soncin F, Prevelige R, Calderwood SK. Expression and purification of human heat-shock transcription factor 1. Protein Expr Purif. 1997 Feb; 9(1):27-32.
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  114. Cahill CM, Lin HS, Price BD, Bruce JL, Calderwood SK. Potential role of heat shock transcription factor in the expression of inflammatory cytokines. Adv Exp Med Biol. 1997; 400B:625-30.
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  115. Soncin F, Calderwood SK. Reciprocal effects of pro-inflammatory stimuli and anti-inflammatory drugs on the activity of heat shock factor-1 in human monocytes. Biochem Biophys Res Commun. 1996 Dec 13; 229(2):479-84.
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  116. Chu B, Soncin F, Price BD, Stevenson MA, Calderwood SK. Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1. J Biol Chem. 1996 Nov 29; 271(48):30847-57.
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  117. Cahill CM, Waterman WR, Xie Y, Auron PE, Calderwood SK. Transcriptional repression of the prointerleukin 1beta gene by heat shock factor 1. J Biol Chem. 1996 Oct 4; 271(40):24874-9.
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  118. Di YP, Repasky E, Laszlo A, Calderwood S, Subjeck J. Hsp70 translocates into a cytoplasmic aggregate during lymphocyte activation. J Cell Physiol. 1995 Nov; 165(2):228-38.
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  119. Nunes SL, Calderwood SK. Heat shock factor-1 and the heat shock cognate 70 protein associate in high molecular weight complexes in the cytoplasm of NIH-3T3 cells. Biochem Biophys Res Commun. 1995 Aug 4; 213(1):1-6.
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  120. Stevenson MA, Pollock SS, Coleman CN, Calderwood SK. X-irradiation, phorbol esters, and H2O2 stimulate mitogen-activated protein kinase activity in NIH-3T3 cells through the formation of reactive oxygen intermediates. Cancer Res. 1994 Jan 1; 54(1):12-5.
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  121. Price BD, Calderwood SK. Increased sequence-specific p53-DNA binding activity after DNA damage is attenuated by phorbol esters. Oncogene. 1993 Nov; 8(11):3055-62.
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  122. Calderwood SK, Stevenson MA, Price BD. Activation of phospholipase C by heat shock requires GTP analogs and is resistant to pertussis toxin. J Cell Physiol. 1993 Jul; 156(1):153-9.
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  123. Tishler RB, Calderwood SK, Coleman CN, Price BD. Increases in sequence specific DNA binding by p53 following treatment with chemotherapeutic and DNA damaging agents. Cancer Res. 1993 May 15; 53(10 Suppl):2212-6.
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  124. Calderwood SK, Stevenson MA. Inducers of the heat shock response stimulate phospholipase C and phospholipase A2 activity in mammalian cells. J Cell Physiol. 1993 May; 155(2):248-56.
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  125. Bruce JL, Price BD, Coleman CN, Calderwood SK. Oxidative injury rapidly activates the heat shock transcription factor but fails to increase levels of heat shock proteins. Cancer Res. 1993 Jan 1; 53(1):12-5.
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  126. Price BD, Calderwood SK. Heat-induced transcription from RNA polymerases II and III and HSF binding activity are co-ordinately regulated by the products of the heat shock genes. J Cell Physiol. 1992 Nov; 153(2):392-401.
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  127. Price BD, Mannheim-Rodman LA, Calderwood SK. Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis. J Cell Physiol. 1992 Sep; 152(3):545-52.
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  128. Price BD, Calderwood SK. Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins. Cancer Res. 1992 Jul 1; 52(13):3814-7.
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  129. Lam KT, Calderwood SK. hsp70 binds specifically to a peptide derived from the highly conserved domain (I) region of p53. Biochem Biophys Res Commun. 1992 Apr 15; 184(1):167-74.
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  130. Bader SB, Price BD, Mannheim-Rodman LA, Calderwood SK. Inhibition of heat shock gene expression does not block the development of thermotolerance. J Cell Physiol. 1992 Apr; 151(1):56-62.
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  131. Price BD, Calderwood SK. Ca2+ is essential for multistep activation of the heat shock factor in permeabilized cells. Mol Cell Biol. 1991 Jun; 11(6):3365-8.
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  132. Hensold JO, Hunt CR, Calderwood SK, Housman DE, Kingston RE. DNA binding of heat shock factor to the heat shock element is insufficient for transcriptional activation in murine erythroleukemia cells. Mol Cell Biol. 1990 Apr; 10(4):1600-8.
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  133. Hunt C, Calderwood S. Characterization and sequence of a mouse hsp70 gene and its expression in mouse cell lines. Gene. 1990 Mar 15; 87(2):199-204.
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  134. Stevenson MA, Calderwood SK. Members of the 70-kilodalton heat shock protein family contain a highly conserved calmodulin-binding domain. Mol Cell Biol. 1990 Mar; 10(3):1234-8.
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  135. Calderwood SK, Bornstein B, Farnum EK, Stevenson MA. Heat shock stimulates the release of arachidonic acid and the synthesis of prostaglandins and leukotriene B4 in mammalian cells. J Cell Physiol. 1989 Nov; 141(2):325-33.
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  136. Stevenson MA, Calderwood SK, Coleman CN. Effects of nitroimidazoles on neuronal cells in vitro. Int J Radiat Oncol Biol Phys. 1989 May; 16(5):1225-30.
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  137. Oleson JR, Calderwood SK, Coughlin CT, Dewhirst MW, Gerweck LE, Gibbs FA, Kapp DS. Biological and clinical aspects of hyperthermia in cancer therapy. Am J Clin Oncol. 1988 Jun; 11(3):368-80.
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  138. Calderwood SK, Stevenson MA, Hahn GM. Effects of heat on cell calcium and inositol lipid metabolism. Radiat Res. 1988 Mar; 113(3):414-25.
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  139. Stevenson MA, Calderwood SK, Hahn GM. Effect of hyperthermia (45 degrees C) on calcium flux in Chinese hamster ovary HA-1 fibroblasts and its potential role in cytotoxicity and heat resistance. Cancer Res. 1987 Jul 15; 47(14):3712-7.
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  140. Calderwood SK, Stevenson MA, Hahn GM. Heat stress stimulates inositol trisphosphate release and phosphorylation of phosphoinositides in CHO and Balb C 3T3 cells. J Cell Physiol. 1987 Mar; 130(3):369-76.
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  141. Calderwood SK. Role of energy in cellular responses to heat. Symp Soc Exp Biol. 1987; 41:213-33.
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  142. Calderwood SK, Stevenson MA, Modlinsky M, Hahn GM. Binding of polycation DEAE-dextran to Chinese hamster ovary cells induces reversible Ca2+ influx and inhibits capping of concanavalin A acceptor proteins. Biochim Biophys Acta. 1986 Dec 19; 889(3):316-25.
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  143. Stevenson MA, Calderwood SK, Hahn GM. Rapid increases in inositol trisphosphate and intracellular Ca++ after heat shock. Biochem Biophys Res Commun. 1986 Jun 13; 137(2):826-33.
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  144. Calderwood SK, Bump EA, Stevenson MA, Van Kersen I, Hahn GM. Investigation of adenylate energy charge, phosphorylation potential, and ATP concentration in cells stressed with starvation and heat. J Cell Physiol. 1985 Aug; 124(2):261-8.
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  145. Calderwood SK, Stevenson MA, Hahn GM. Cyclic AMP and the heat shock response in Chinese hamster ovary cells. Biochem Biophys Res Commun. 1985 Jan 31; 126(2):911-6.
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  146. Modlinski M, Calderwood SK, Stevenson MA, Hahn GM. The polycation diethylaminoethyl dextran potentiates thermal cell killing. Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Nov; 46(5):587-96.
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  147. Bump EA, Calderwood SK, Sawyer JM, Brown JM. Role of the adenylate energy charge in the response of Chinese hamster ovary cells to radiation. Int J Radiat Oncol Biol Phys. 1984 Aug; 10(8):1411-4.
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  148. Tao TW, Calderwood S, Hahn GM. Stable heat-resistant clones selected from wild-type and surface variants of B-16 melanoma. Int J Cancer. 1983 Nov 15; 32(5):533-5.
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  149. Calderwood SK, Armour EP, Hahn GM. Concomitant up-regulation of insulin binding and elevated heat sensitivity in serum depleted CHO cells. Cell Biol Int Rep. 1983 Oct; 7(10):869-73.
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  150. Calderwood SK, Hahn GM. Thermal sensitivity and resistance of insulin-receptor binding in thermotolerant cells. Biochim Biophys Acta. 1983 Sep 21; 734(1):76-82.
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  151. Calderwood SK, Hahn GM. Thermal sensitivity and resistance of insulin-receptor binding. Biochim Biophys Acta. 1983 Mar 15; 756(1):1-8.
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  152. Calderwood SK, Dickson JA. Effect of hyperglycemia on blood flow, pH, and response to hyperthermia (42 degrees) of the Yoshida sarcoma in the rat. Cancer Res. 1980 Dec; 40(12):4728-33.
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  153. Dickson JA, Calderwood SK. Temperature range and selective sensitivity of tumors to hyperthermia: a critical review. Ann N Y Acad Sci. 1980; 335:180-205.
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  154. Calderwood SK, Dickson JA. Influence of tumour volume and cell kinetics on the response of the solid Yoshida sarcoma to hyperthermia (42 degrees C). Br J Cancer. 1980 Jan; 41(1):22-32.
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  155. Dickson JA, Calderwood SK. Effects of hyperglycemia and hyperthermia on the pH, glycolysis, and respiration of the Yoshida sarcoma in vivo. J Natl Cancer Inst. 1979 Dec; 63(6):1371-81.
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