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Dana H. Boyd, Ph.D.

TitleLecturer on Microbiology and Immunobiology
InstitutionHarvard Medical School
DepartmentMicrobiology and Immunobiology
AddressHarvard Inst of Medicine
Microbiology and Immunobiology, Room 1049
4 Blackfan Cir
Boston MA 02115
Phone617/432-1921
Fax617/738-7664

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. O'Connor TJ, Boyd D, Dorer MS, Isberg RR. Aggravating genetic interactions allow a solution to redundancy in a bacterial pathogen. Science. 2012 Dec 14; 338(6113):1440-4.
    View in: PubMed
  2. Gray AN, Henderson-Frost JM, Boyd D, Sharafi S, Niki H, Goldberg MB. Unbalanced Charge Distribution as a Determinant for Dependence of a Subset of Escherichia coli Membrane Proteins on the Membrane Insertase YidC. MBio. 2012; 3(6).
    View in: PubMed
  3. Chng SS, Xue M, Garner RA, Kadokura H, Boyd D, Beckwith J, Kahne D. Disulfide rearrangement triggered by translocon assembly controls lipopolysaccharide export. Science. 2012 Sep 28; 337(6102):1665-8.
    View in: PubMed
  4. Gray AN, Henderson-Frost JM, Boyd D, Shirafi S, Niki H, Goldberg MB. Unbalanced charge distribution as a determinant for dependence of a subset of Escherichia coli membrane proteins on the membrane insertase YidC. MBio. 2011; 2(6).
    View in: PubMed
  5. O'Connor TJ, Adepoju Y, Boyd D, Isberg RR. Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion. Proc Natl Acad Sci U S A. 2011 Sep 6; 108(36):14733-40.
    View in: PubMed
  6. Feeney MA, Veeravalli K, Boyd D, Gon S, Faulkner MJ, Georgiou G, Beckwith J. Repurposing lipoic acid changes electron flow in two important metabolic pathways of Escherichia coli. Proc Natl Acad Sci U S A. 2011 May 10; 108(19):7991-6.
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  7. Wang X, Dutton RJ, Beckwith J, Boyd D. Membrane topology and mutational analysis of Mycobacterium tuberculosis VKOR, a protein involved in disulfide bond formation and a homologue of human vitamin K epoxide reductase. Antioxid Redox Signal. 2011 Apr 15; 14(8):1413-20.
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  8. Veeravalli K, Boyd D, Iverson BL, Beckwith J, Georgiou G. Laboratory evolution of glutathione biosynthesis reveals natural compensatory pathways. Nat Chem Biol. 2011 Feb; 7(2):101-5.
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  9. Huang L, Boyd D, Amyot WM, Hempstead AD, Luo ZQ, O'Connor TJ, Chen C, Machner M, Montminy T, Isberg RR. The E Block motif is associated with Legionella pneumophila translocated substrates. Cell Microbiol. 2011 Feb; 13(2):227-45.
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  10. Gonzalez MD, Akbay EA, Boyd D, Beckwith J. Multiple interaction domains in FtsL, a protein component of the widely conserved bacterial FtsLBQ cell division complex. J Bacteriol. 2010 Jun; 192(11):2757-68.
    View in: PubMed
  11. Li W, Schulman S, Dutton RJ, Boyd D, Beckwith J, Rapoport TA. Structure of a bacterial homologue of vitamin K epoxide reductase. Nature. 2010 Jan 28; 463(7280):507-12.
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  12. Dutton RJ, Wayman A, Wei JR, Rubin EJ, Beckwith J, Boyd D. Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin. Proc Natl Acad Sci U S A. 2010 Jan 5; 107(1):297-301.
    View in: PubMed
  13. Shouldice SR, Cho SH, Boyd D, Heras B, Eser M, Beckwith J, Riggs P, Martin JL, Berkmen M. In vivo oxidative protein folding can be facilitated by oxidation-reduction cycling. Mol Microbiol. 2010 Jan; 75(1):13-28.
    View in: PubMed
  14. Dutton RJ, Boyd D, Berkmen M, Beckwith J. Bacterial species exhibit diversity in their mechanisms and capacity for protein disulfide bond formation. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11933-8.
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  15. Yamamoto Y, Ritz D, Planson AG, J├Ânsson TJ, Faulkner MJ, Boyd D, Beckwith J, Poole LB. Mutant AhpC peroxiredoxins suppress thiol-disulfide redox deficiencies and acquire deglutathionylating activity. Mol Cell. 2008 Jan 18; 29(1):36-45.
    View in: PubMed
  16. Mac TT, von Hacht A, Hung KC, Dutton RJ, Boyd D, Bardwell JC, Ulmer TS. Insight into disulfide bond catalysis in Chlamydia from the structure and function of DsbH, a novel oxidoreductase. J Biol Chem. 2008 Jan 11; 283(2):824-32.
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  17. Charity JC, Costante-Hamm MM, Balon EL, Boyd DH, Rubin EJ, Dove SL. Twin RNA polymerase-associated proteins control virulence gene expression in Francisella tularensis. PLoS Pathog. 2007 Jun; 3(6):e84.
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  18. Li W, Schulman S, Boyd D, Erlandson K, Beckwith J, Rapoport TA. The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal. Mol Cell. 2007 May 25; 26(4):511-21.
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  19. Eser M, Henrichs T, Boyd D, Ehrmann M. Target-directed proteolysis in vivo. Methods Enzymol. 2007; 421:68-83.
    View in: PubMed
  20. Goehring NW, Petrovska I, Boyd D, Beckwith J. Mutants, suppressors, and wrinkled colonies: mutant alleles of the cell division gene ftsQ point to functional domains in FtsQ and a role for domain 1C of FtsA in divisome assembly. J Bacteriol. 2007 Jan; 189(2):633-45.
    View in: PubMed
  21. Huber D, Boyd D, Xia Y, Olma MH, Gerstein M, Beckwith J. Use of thioredoxin as a reporter to identify a subset of Escherichia coli signal sequences that promote signal recognition particle-dependent translocation. J Bacteriol. 2005 May; 187(9):2983-91.
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  22. Henrichs T, Mikhaleva N, Conz C, Deuerling E, Boyd D, Zelazny A, Bibi E, Ban N, Ehrmann M. Target-directed proteolysis at the ribosome. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4246-51.
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  23. Berkmen M, Boyd D, Beckwith J. The nonconsecutive disulfide bond of Escherichia coli phytase (AppA) renders it dependent on the protein-disulfide isomerase, DsbC. J Biol Chem. 2005 Mar 25; 280(12):11387-94.
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  24. Or E, Boyd D, Gon S, Beckwith J, Rapoport T. The bacterial ATPase SecA functions as a monomer in protein translocation. J Biol Chem. 2005 Mar 11; 280(10):9097-105.
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  25. Goodman AL, Kulasekara B, Rietsch A, Boyd D, Smith RS, Lory S. A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa. Dev Cell. 2004 Nov; 7(5):745-54.
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  26. Ehrle R, Mikhaleva N, Boyd D, Davidson AL, Ehrmann M. Context-dependent effects of charged residues in transmembrane segments of MalF-PhoA fusions. Res Microbiol. 2003 Nov; 154(9):654-7.
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  27. Schierle CF, Berkmen M, Huber D, Kumamoto C, Boyd D, Beckwith J. The DsbA signal sequence directs efficient, cotranslational export of passenger proteins to the Escherichia coli periplasm via the signal recognition particle pathway. J Bacteriol. 2003 Oct; 185(19):5706-13.
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  28. Wolfgang MC, Kulasekara BR, Liang X, Boyd D, Wu K, Yang Q, Miyada CG, Lory S. Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A. 2003 Jul 8; 100(14):8484-9.
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  29. Sassetti CM, Boyd DH, Rubin EJ. Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol. 2003 Apr; 48(1):77-84.
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  30. Buddelmeijer N, Judson N, Boyd D, Mekalanos JJ, Beckwith J. YgbQ, a cell division protein in Escherichia coli and Vibrio cholerae, localizes in codependent fashion with FtsL to the division site. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6316-21.
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  31. Dziejman M, Balon E, Boyd D, Fraser CM, Heidelberg JF, Mekalanos JJ. Comparative genomic analysis of Vibrio cholerae: genes that correlate with cholera endemic and pandemic disease. Proc Natl Acad Sci U S A. 2002 Feb 5; 99(3):1556-61.
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  32. Sassetti CM, Boyd DH, Rubin EJ. Comprehensive identification of conditionally essential genes in mycobacteria. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12712-7.
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  33. Leeds JA, Boyd D, Huber DR, Sonoda GK, Luu HT, Engelman DM, Beckwith J. Genetic selection for and molecular dynamic modeling of a protein transmembrane domain multimerization motif from a random Escherichia coli genomic library. J Mol Biol. 2001 Oct 12; 313(1):181-95.
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  34. Kwon O, Georgellis D, Lynch AS, Boyd D, Lin EC. The ArcB sensor kinase of Escherichia coli: genetic exploration of the transmembrane region. J Bacteriol. 2000 May; 182(10):2960-6.
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  35. Tian H, Boyd D, Beckwith J. A mutant hunt for defects in membrane protein assembly yields mutations affecting the bacterial signal recognition particle and Sec machinery. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4730-5.
    View in: PubMed
  36. Boyd D, Weiss DS, Chen JC, Beckwith J. Towards single-copy gene expression systems making gene cloning physiologically relevant: lambda InCh, a simple Escherichia coli plasmid-chromosome shuttle system. J Bacteriol. 2000 Feb; 182(3):842-7.
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  37. Pellicer MT, Lynch AS, De Wulf P, Boyd D, Aguilar J, Lin EC. A mutational study of the ArcA-P binding sequences in the aldA promoter of Escherichia coli. Mol Gen Genet. 1999 Feb; 261(1):170-6.
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  38. Weiss DS, Chen JC, Ghigo JM, Boyd D, Beckwith J. Localization of FtsI (PBP3) to the septal ring requires its membrane anchor, the Z ring, FtsA, FtsQ, and FtsL. J Bacteriol. 1999 Jan; 181(2):508-20.
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  39. Pogliano J, Dong JM, De Wulf P, Furlong D, Boyd D, Losick R, Pogliano K, Lin EC. Aberrant cell division and random FtsZ ring positioning in Escherichia coli cpxA* mutants. J Bacteriol. 1998 Jul; 180(13):3486-90.
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  40. Prinz WA, Boyd DH, Ehrmann M, Beckwith J. The protein translocation apparatus contributes to determining the topology of an integral membrane protein in Escherichia coli. J Biol Chem. 1998 Apr 3; 273(14):8419-24.
    View in: PubMed
  41. Boyd D, Schierle C, Beckwith J. How many membrane proteins are there? Protein Sci. 1998 Jan; 7(1):201-5.
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  42. Traxler B, Boyd D, Beckwith J. The topological analysis of integral cytoplasmic membrane proteins. J Membr Biol. 1993 Feb; 132(1):1-11.
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  43. Boyd D, Traxler B, Beckwith J. Analysis of the topology of a membrane protein by using a minimum number of alkaline phosphatase fusions. J Bacteriol. 1993 Jan; 175(2):553-6.
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  44. Boyd D, Traxler B, Jander G, Prinz W, Beckwith J. Gene fusion approaches to membrane protein topology. Soc Gen Physiol Ser. 1993; 48:23-37.
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  45. Traxler B, Lee C, Boyd D, Beckwith J. The dynamics of assembly of a cytoplasmic membrane protein in Escherichia coli. J Biol Chem. 1992 Mar 15; 267(8):5339-45.
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  46. Ehrmann M, Boyd D, Beckwith J. Genetic analysis of membrane protein topology by a sandwich gene fusion approach. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7574-8.
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  47. Boyd D, Beckwith J. The role of charged amino acids in the localization of secreted and membrane proteins. Cell. 1990 Sep 21; 62(6):1031-3.
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  48. Boyd D, Beckwith J. Positively charged amino acid residues can act as topogenic determinants in membrane proteins. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9446-50.
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  49. San Millan JL, Boyd D, Dalbey R, Wickner W, Beckwith J. Use of phoA fusions to study the topology of the Escherichia coli inner membrane protein leader peptidase. J Bacteriol. 1989 Oct; 171(10):5536-41.
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  50. Manoil C, Boyd D, Beckwith J. Molecular genetic analysis of membrane protein topology. Trends Genet. 1988 Aug; 4(8):223-6.
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  51. Froshauer S, Green GN, Boyd D, McGovern K, Beckwith J. Genetic analysis of the membrane insertion and topology of MalF, a cytoplasmic membrane protein of Escherichia coli. J Mol Biol. 1988 Apr 5; 200(3):501-11.
    View in: PubMed
  52. Boyd D, Manoil C, Beckwith J. Determinants of membrane protein topology. Proc Natl Acad Sci U S A. 1987 Dec; 84(23):8525-9.
    View in: PubMed
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