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Institution

Igor Kissin, PH.D., M.D.

TitleProfessor of Anaesthesia
InstitutionBrigham and Women's Hospital
DepartmentAnaesthesia
AddressBrigham and Women's Hospital
Anesthesia
75 Francis St
Boston MA 02115
Phone617/732-7362
Fax617/734-0682

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kissin I. Long-term opioid treatment of chronic nonmalignant pain: unproven efficacy and neglected safety? J Pain Res. 2013; 6:513-29.
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  2. Kissin I. An early indicator of drug success: Top Journal Selectivity Index. Drug Des Devel Ther. 2013; 7:93-8.
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  3. Kissin I, Gelman S. Chronic postsurgical pain: still a neglected topic? J Pain Res. 2012; 5:473-89.
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  4. Kissin I. How does the lidocaine patch (5%) relieve pain? Pain. 2012 Jun; 153(6):1332-3.
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  5. Vlassakov KV, Narang S, Kissin I. Cutaneous anesthesia in neuropathic pain: Systematic analysis. J Anesth Clin Res. 2012; 3(3):1000199.
  6. Kissin I, Bradley EL Jr. Top Journal Selectivity Index and "me-too" drugs. Scientometrics. 2012; 91(1):131-42.
  7. Kissin I. A call to reassess the clinical value of preventive (preemptive) analgesia. Anesth Analg. 2011 Nov; 113(5):977-8.
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  8. Kissin I, Bradley EL Jr. Top Journal Selectivity Index: Is it acceptable for drugs beyond the field of analgesia? Scientometrics. 2011; 88(2):589- 97.
  9. Kissin I. Can a bibliometric indicator predict the success of an analgesic? Scientometrics. 2011; 86(3):785-95.
  10. Vlassakov KV, Narang S, Kissin I. Local anesthetic blockade of peripheral nerves for treatment of neuralgias: systematic analysis. Anesth Analg. 2011 Jun; 112(6):1487-93.
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  11. Kissin I, Szallasi A. Therapeutic targeting of TRPV1 by resiniferatoxin, from preclinical studies to clinical trials. Curr Top Med Chem. 2011; 11(17):2159-70.
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  12. Kissin I. The development of new analgesics over the past 50 years: a lack of real breakthrough drugs. Anesth Analg. 2010 Mar 1; 110(3):780-9.
    View in: PubMed
  13. Kissin I. Preemptive analgesia: problems with assessment of clinical significance. Methods Mol Biol. 2010; 617:475-82.
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  14. Kissin I. Patient-controlled-analgesia analgesimetry and its problems. Anesth Analg. 2009 Jun; 108(6):1945-9.
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  15. Sugimoto K, Kissin I, Strichartz G. A high concentration of resiniferatoxin inhibits ion channel function in clonal neuroendocrine cells. Anesth Analg. 2008 Jul; 107(1):318-24.
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  16. Kissin I. Vanilloid-induced conduction analgesia: selective, dose-dependent, long-lasting, with a low level of potential neurotoxicity. Anesth Analg. 2008 Jul; 107(1):271-81.
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  17. Yukhananov R, Kissin I. Persistent changes in spinal cord gene expression after recovery from inflammatory hyperalgesia: a preliminary study on pain memory. BMC Neurosci. 2008; 9:32.
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  18. Kissin I, Freitas CF, Mulhern HL, DeGirolami U. Sciatic nerve block with resiniferatoxin: an electron microscopic study of unmyelinated fibers in the rat. Anesth Analg. 2007 Sep; 105(3):825-31.
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  19. Kissin I, Freitas CF, Bradley EL. Perineural resiniferatoxin prevents the development of hyperalgesia produced by loose ligation of the sciatic nerve in rats. Anesth Analg. 2007 May; 104(5):1210-6, tables of contents.
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  20. Kissin I, Freitas CF, Bradley EL. Memory of pain: the effect of perineural resiniferatoxin. Anesth Analg. 2006 Sep; 103(3):721-8.
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  21. Wasan AD, Correll DJ, Kissin I, O'Shea S, Jamison RN. Iatrogenic addiction in patients treated for acute or subacute pain: a systematic review. J Opioid Manag. 2006 Jan-Feb; 2(1):16-22.
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  22. Kissin I. Tolerance to opioid analgesia: why do we differ from rats? Anesth Analg. 2005 Dec; 101(6):1727-9.
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  23. Kissin EY, Freitas CF, Kissin I. The effects of intraarticular resiniferatoxin in experimental knee-joint arthritis. Anesth Analg. 2005 Nov; 101(5):1433-9.
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  24. Kissin I, Davison N, Bradley EL. Perineural resiniferatoxin prevents hyperalgesia in a rat model of postoperative pain. Anesth Analg. 2005 Mar; 100(3):774-80, table of contents.
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  25. Kissin I. Preemptive analgesia at the crossroad. Anesth Analg. 2005 Mar; 100(3):754-6.
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  26. Kissin I, Lee SS. Effects of long-term nerve blockade in the spared nerve injury model. Anesthesiology. 2004 Sep; 101(3):806-7.
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  27. Yukhananov RY, Kissin I. Comment on Zeitz, K.P., et al., Reduced development of tolerance to the analgesic effects of morphine and clonidine in PKC mutant mice, PAIN 94 (2002) 245-253. Pain. 2003 Apr; 102(3):309-10; author reply 310-1.
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  28. Kissin I, Bright CA, Bradley EL. Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity. Anesth Analg. 2002 May; 94(5):1253-8, table of contents.
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  29. Kissin I. Study design to demonstrate clinical value of preemptive analgesia: is the commonly used approach valid? Reg Anesth Pain Med. 2002 May-Jun; 27(3):242-4.
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  30. Kissin I, Bright CA, Bradley EL. Can inflammatory pain prevent the development of acute tolerance to alfentanil? Anesth Analg. 2001 May; 92(5):1296-300.
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  31. Kissin I, Bright CA, Bradley EL. The effect of ketamine on opioid-induced acute tolerance: can it explain reduction of opioid consumption with ketamine-opioid analgesic combinations? Anesth Analg. 2000 Dec; 91(6):1483-8.
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  32. Kissin I. Preemptive analgesia. Anesthesiology. 2000 Oct; 93(4):1138-43.
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  33. Kissin I, Bright CA, Bradley EL. Acute tolerance to continuously infused alfentanil: the role of cholecystokinin and N-methyl-D-aspartate-nitric oxide systems. Anesth Analg. 2000 Jul; 91(1):110-6.
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  34. Kissin I. Depth of anesthesia and bispectral index monitoring. Anesth Analg. 2000 May; 90(5):1114-7.
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  35. Kissin I, Lee SS, Bradley EL. Hyperalgesia caused by nerve transection: long-lasting block prevents early hyperalgesia in the receptive field of the surviving nerve. Anesth Analg. 1999 Dec; 89(6):1475-81.
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  36. Vinik HR, Bradley EL, Kissin I. Isobolographic analysis of propofol-thiopental hypnotic interaction in surgical patients. Anesth Analg. 1999 Mar; 88(3):667-70.
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  37. Tverskoy M, Braslavsky A, Mazor A, Ferman R, Kissin I. The peripheral effect of fentanyl on postoperative pain. Anesth Analg. 1998 Nov; 87(5):1121-4.
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  38. Vinik HR, Kissin I. Rapid development of tolerance to analgesia during remifentanil infusion in humans. Anesth Analg. 1998 Jun; 86(6):1307-11.
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  39. Eappen S, Kissin I. Effect of subarachnoid bupivacaine block on anesthetic requirements for thiopental in rats. Anesthesiology. 1998 Apr; 88(4):1036-42.
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  40. Kissin I, Lee SS, Bradley EL. Effect of prolonged nerve block on inflammatory hyperalgesia in rats: prevention of late hyperalgesia. Anesthesiology. 1998 Jan; 88(1):224-32.
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  41. Kissin I. Anesthetic interactions following bolus injections. J Clin Anesth. 1997 Sep; 9(6 Suppl):14S-17S.
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  42. Kissin I. A concept for assessing interactions of general anesthetics. Anesth Analg. 1997 Jul; 85(1):204-10.
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  43. Kissin I, Lee SS, Arthur GR, Bradley EL. Effect of midazolam on development of acute tolerance to alfentanil: the role of pharmacokinetic interactions. Anesth Analg. 1997 Jul; 85(1):182-7.
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  44. Choi RH, Birknes JK, Popitz-Bergez FA, Kissin I, Strichartz GR. Pharmacokinetic nature of tachyphylaxis to lidocaine: peripheral nerve blocks and infiltration anesthesia in rats. Life Sci. 1997; 61(12):PL 177-84.
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  45. Kissin I, Lee SS, Arthur GR, Bradley EL. Time course characteristics of acute tolerance development to continuously infused alfentanil in rats. Anesth Analg. 1996 Sep; 83(3):600-5.
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  46. Tverskoy M, Oren M, Vaskovich M, Dashkovsky I, Kissin I. Ketamine enhances local anesthetic and analgesic effects of bupivacaine by peripheral mechanism: a study in postoperative patients. Neurosci Lett. 1996 Aug 30; 215(1):5-8.
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  47. Tverskoy M, Oren M, Dashkovsky I, Kissin I. Alfentanil dose-response relationships for relief of postoperative pain. Anesth Analg. 1996 Aug; 83(2):387-93.
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  48. Tverskoy M, Shagal M, Finger J, Kissin I. Spinal anesthesia and midazolam hypnotic requirements. Anesth Analg. 1996 Jul; 83(1):198-9.
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  49. Tverskoy M, Shifrin V, Finger J, Fleyshman G, Kissin I. Effect of epidural bupivacaine block on midazolam hypnotic requirements. Reg Anesth. 1996 May-Jun; 21(3):209-13.
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  50. Kissin I. Preemptive analgesia. Why its effect is not always obvious. Anesthesiology. 1996 May; 84(5):1015-9.
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  51. Kissin I, Tverskoy M. Another explanation for reduced meperidine consumption in the immediate postoperative period. Anesth Analg. 1995 Jan; 80(1):214.
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  52. Tverskoy M, Shagal M, Finger J, Kissin I. Subarachnoid bupivacaine blockade decreases midazolam and thiopental hypnotic requirements. J Clin Anesth. 1994 Nov-Dec; 6(6):487-90.
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  53. Kissin I. Preemptive analgesia: terminology and clinical relevance. Anesth Analg. 1994 Oct; 79(4):809-10.
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  54. Tverskoy M, Oz Y, Isakson A, Finger J, Bradley EL, Kissin I. Preemptive effect of fentanyl and ketamine on postoperative pain and wound hyperalgesia. Anesth Analg. 1994 Feb; 78(2):205-9.
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  55. Vinik HR, Bradley EL, Kissin I. Triple anesthetic combination: propofol-midazolam-alfentanil. Anesth Analg. 1994 Feb; 78(2):354-8.
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  56. Mehta D, Bradley EL, Kissin I. Metoclopramide decreases thiopental hypnotic requirements. Anesth Analg. 1993 Oct; 77(4):784-7.
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  57. DeLorey TM, Kissin I, Brown P, Brown GB. Barbiturate-benzodiazepine interactions at the gamma-aminobutyric acidA receptor in rat cerebral cortical synaptoneurosomes. Anesth Analg. 1993 Sep; 77(3):598-605.
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  58. Kissin I, Stanski DR, Brown PT, Bradley EL. Pentobarbital-morphine anesthetic interactions in terms of intensity of noxious stimulation required for arousal. Anesthesiology. 1993 Apr; 78(4):744-9.
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  59. Kissin I. General anesthetic action: an obsolete notion? Anesth Analg. 1993 Feb; 76(2):215-8.
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  60. Jebeles JA, Reilly JS, Gutierrez JF, Bradley EL, Kissin I. Tonsillectomy and adenoidectomy pain reduction by local bupivacaine infiltration in children. Int J Pediatr Otorhinolaryngol. 1993 Jan; 25(1-3):149-54.
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  61. Kissin I, Brown PT, Bradley EL. Does midazolam inhibit the development of acute tolerance to the analgesic effect of alfentanil? Life Sci. 1993; 52(8):PL55-60.
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  62. Kissin I, Brown PT, Bradley EL. Locomotor activity after recovery from hypnosis: midazolam-morphine versus midazolam. Anesth Analg. 1992 Dec; 75(6):929-31.
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  63. Roytblat L, Katz J, Rozentsveig V, Gesztes T, Bradley EL, Kissin I. Anaesthetic interaction between thiopentone and ketamine. Eur J Anaesthesiol. 1992 Jul; 9(4):307-12.
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  64. Jebeles JA, Reilly JS, Gutierrez JF, Bradley EL, Kissin I. The effect of pre-incisional infiltration of tonsils with bupivacaine on the pain following tonsillectomy under general anesthesia. Pain. 1991 Dec; 47(3):305-8.
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  65. Kissin I, Brown PT, Bradley EL. Magnitude of acute tolerance to opioids is not related to their potency. Anesthesiology. 1991 Nov; 75(5):813-6.
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  66. Kissin I, Brown PT, Robinson CA, Bradley EL. Acute tolerance to the hypnotic effect of morphine in rats. Anesth Analg. 1991 Nov; 73(5):619-21.
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  67. Kissin I, Vinik HR, Bradley EL. Midazolam potentiates thiopental sodium anesthetic induction in patients. J Clin Anesth. 1991 Sep-Oct; 3(5):367-70.
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  68. Kissin I, Brown PT, Johannson ML. Map of contributions to Anesthesiology and Anesthesia and Analgesia. Anesth Analg. 1991 Aug; 73(2):233-5.
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  69. Mehta D, Bradley EL, Kissin I. Effect of alfentanil on hypnotic and antinociceptive components of thiopental sodium anesthesia. J Clin Anesth. 1991 Jul-Aug; 3(4):280-4.
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  70. Vinik HR, Kissin I. Sedation in the ICU. Intensive Care Med. 1991; 17 Suppl 1:S20-3.
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  71. Kissin I, Brown PT, Robinson CA, Bradley EL. Acute tolerance in morphine analgesia: continuous infusion and single injection in rats. Anesthesiology. 1991 Jan; 74(1):166-71.
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  72. Crisologo PA, Neal B, Brown R, McDanal J, Kissin I. Lidocaine-induced spinal block can relieve central poststroke pain: role of the block in chronic pain diagnosis. Anesthesiology. 1991 Jan; 74(1):184-5.
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  73. Kissin I, Brown PT, Bradley EL. Morphine and fentanyl anesthetic interactions with diazepam: relative antagonism in rats. Anesth Analg. 1990 Sep; 71(3):236-41.
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  74. Kissin I, Brown PT, Bradley EL. Sedative and hypnotic midazolam-morphine interactions in rats. Anesth Analg. 1990 Aug; 71(2):137-43.
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  75. Kissin I, Vinik HR, Castillo R, Bradley EL. Alfentanil potentiates midazolam-induced unconsciousness in subanalgesic doses. Anesth Analg. 1990 Jul; 71(1):65-9.
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  76. Xavier AV, Farrell CE, McDanal J, Kissin I. Does antidromic activation of nociceptors play a role in sciatic radicular pain? Pain. 1990 Jan; 40(1):77-9.
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  77. Tverskoy M, Cozacov C, Ayache M, Bradley EL, Kissin I. Postoperative pain after inguinal herniorrhaphy with different types of anesthesia. Anesth Analg. 1990 Jan; 70(1):29-35.
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  78. Kissin I, Xavier AV, McDanal J. Blockade of sciatic nerve branches relieves sciatic radicular pain. Anesth Analg. 1989 Aug; 69(2):262-3.
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  79. Kissin I, McDanal J, Xavier AV. Topical lidocaine for relief of superficial pain in postherpetic neuralgia. Neurology. 1989 Aug; 39(8):1132-3.
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  80. Vinik HR, Bradley EL, Kissin I. Midazolam-alfentanil synergism for anesthetic induction in patients. Anesth Analg. 1989 Aug; 69(2):213-7.
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  81. Kissin I, Gelman S. Isoflurane: myocardial ischemia without coronary steal? Anesth Analg. 1989 Jun; 68(6):825-6.
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  82. Kissin I, Brown PT, Bradley EL, Robinson CA, Cassady JL. Diazepam--morphine hypnotic synergism in rats. Anesthesiology. 1989 Apr; 70(4):689-94.
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  83. Xavier AV, McDanal J, Kissin I. Mechanism of pain caused by the nerve-root tension test in patients with sciatica. Neurology. 1989 Apr; 39(4):601-2.
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  84. Tverskoy M, Fleyshman G, Ezry J, Bradley EL, Kissin I. Midazolam-morphine sedative interaction in patients. Anesth Analg. 1989 Mar; 68(3):282-5.
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  85. Xavier AV, McDanal J, Kissin I. Relief of sciatic radicular pain by sciatic nerve block. Anesth Analg. 1988 Dec; 67(12):1177-80.
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  86. Kissin I, Gelman S. Components of anaesthesia. Br J Anaesth. 1988 Aug; 61(2):237-8.
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  87. Kissin I, Wright AJ. The introduction of hedonal: a Russian contribution to intravenous anesthesia. Anesthesiology. 1988 Aug; 69(2):242-5.
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  88. Tverskoy M, Fleyshman G, Bradley EL, Kissin I. Midazolam-thiopental anesthetic interaction in patients. Anesth Analg. 1988 Apr; 67(4):342-5.
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  89. Kissin I, McDanal J, Brown PT, Xavier AV, Bradley EL. Sympathetic blockade increases tactile sensitivity. Anesth Analg. 1987 Dec; 66(12):1251-5.
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  90. Daghero AM, Bradley EL, Kissin I. Midazolam antagonizes the analgesic effect of morphine in rats. Anesth Analg. 1987 Oct; 66(10):944-7.
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  91. Kissin I, Mason JO, Bradley EL. Morphine and fentanyl hypnotic interactions with thiopental. Anesthesiology. 1987 Sep; 67(3):331-5.
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  92. Kissin I, Mason JO, Bradley EL. Pentobarbital and thiopental anesthetic interactions with midazolam. Anesthesiology. 1987 Jul; 67(1):26-31.
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  93. Kissin I, Mason JO, Vinik HR, McDanal J, Bradley EL. Barbiturates inhibit stress-induced analgesia. Can J Anaesth. 1987 Mar; 34(2):146-51.
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  94. Kissin I, Gelman S. Three components of anesthesia: one more reason to accept the concept. Anesth Analg. 1987 Jan; 66(1):98.
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  95. Kissin I, Mason JO, Bradley EL. Morphine and fentanyl interactions with thiopental in relation to movement response to noxious stimulation. Anesth Analg. 1986 Nov; 65(11):1149-54.
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  96. Jebeles JA, Kissin I, Bradley EL. Spinal and supraspinal mechanisms for morphine-pentobarbital antinociceptive interaction in relation to cardiac acceleration response in rats. Anesth Analg. 1986 Jun; 65(6):601-4.
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  97. Castillo R, Kissin I, Bradley EL. Selective kappa opioid agonist for spinal analgesia without the risk of respiratory depression. Anesth Analg. 1986 Apr; 65(4):350-4.
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  98. Kissin I. Morphine-halothane interaction controversy. Anesth Analg. 1986 Mar; 65(3):319-21.
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  99. Person DL, Kissin I, Brown PT, Xavier AV, Vinik HR, Bradley EL. Morphine--caffeine analgesic interaction in rats. Anesth Analg. 1985 Sep; 64(9):851-6.
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  100. Kissin I, Brown PT. Reserpine-induced changes in anesthetic action of fentanyl. Anesthesiology. 1985 May; 62(5):597-600.
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  101. Menkhaus PG, Reves JG, Kissin I, Alvis JM, Govier AV, Samuelson PN, Lell WA, Henling CE, Bradley E. Cardiovascular effects of esmolol in anesthetized humans. Anesth Analg. 1985 Mar; 64(3):327-34.
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  102. Ritchie G, Ebert JP, Jannett TC, Kissin I, Sheppard LC. A microcomputer based controller for neuromuscular block during surgery. Ann Biomed Eng. 1985; 13(1):3-15.
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  103. Kissin I, Jebeles JA. Halothane antagonizes effect of morphine on the motor reaction threshold in rats. Anesthesiology. 1984 Dec; 61(6):671-6.
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  104. Kissin I, Green D. Effect of halothane on cardiac acceleration response to somatic nerve stimulation in dogs. Anesthesiology. 1984 Dec; 61(6):708-11.
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  105. Kissin I, Jebeles JA. Pentobarbital antagonizes the effect of morphine on cardiac acceleration response to noxious stimulation. Anesth Analg. 1984 Jul; 63(7):669-72.
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  106. Kissin I, Kerr CR, Smith LR. Morphine-halothane interaction in rats. Anesthesiology. 1984 Jun; 60(6):553-61.
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  107. Reves JG, Kissin I, Fournier S. Negative inotropic effects of midazolam. Anesthesiology. 1984 May; 60(5):517-8.
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  108. Kissin I, Kerr CR, Smith LR. Effect of morphine on the heart rate response to noxious stimulation: interaction with halothane and naloxone. Pain. 1984 Apr; 18(4):351-8.
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  109. Reves JG, Kissin I, Fournier SE, Smith LR. Additive negative inotropic effect of a combination of diazepam and fentanyl. Anesth Analg. 1984 Feb; 63(2):97-100.
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  110. Kissin I, Reves JG. Halothane and ischemic injury. Anesthesiology. 1984 Jan; 60(1):74.
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  111. Motomura S, Kissin I, Aultman DF, Reves JG. Effects of fentanyl and nitrous oxide on contractility of blood-perfused papillary muscle of the dog. Anesth Analg. 1984 Jan; 63(1):47-50.
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  112. Kissin I, Motomura S, Aultman DF, Reves JG. Inotropic and anesthetic potencies of etomidate and thiopental in dogs. Anesth Analg. 1983 Nov; 62(11):961-5.
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  113. Kissin I, Kerr CR, Smith LR. Assessment of anaesthetic action of morphine and fentanyl in rats. Can Anaesth Soc J. 1983 Nov; 30(6):623-8.
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  114. Kissin I, Aultman DF, Smith LR. Effects of volatile anesthetics on myocardial oxidation-reduction status assessed by NADH fluorometry. Anesthesiology. 1983 Nov; 59(5):447-52.
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  115. Tosone SR, Reves JG, Kissin I, Smith LR, Fournier SE. Hemodynamic responses to nifedipine in dogs anesthetized with halothane. Anesth Analg. 1983 Oct; 62(10):903-8.
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  116. Marshall AG, Kissin I, Reves JG, Bradley EL, Blackstone EH. Interaction between negative inotropic effects of halothane and nifedipine in the isolated rat heart. J Cardiovasc Pharmacol. 1983 Jul-Aug; 5(4):592-7.
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  117. Kissin I, Morgan PL, Smith LR. Comparison of isoflurane and halothane safety margins in rats. Anesthesiology. 1983 Jun; 58(6):556-61.
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  118. Kissin I, Thomson CT, Smith LR. Effect of halothane on contractile function of ischemic myocardium. J Cardiovasc Pharmacol. 1983 May-Jun; 5(3):438-42.
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  119. Kissin I, Morgan PL. Heart rate response to nociceptive stimulation as an index of anesthetic potency for enflurane. Anesthesiology. 1983 Jan; 58(1):109-10.
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  120. Kissin I, Morgan PL, Smith LR. Anesthetic potencies of isoflurane, halothane, and diethyl ether for various end points of anesthesia. Anesthesiology. 1983 Jan; 58(1):88-92.
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  121. Reves JG, Kissin I, Lell WA, Tosone S. Calcium entry blockers: uses and implications for anesthesiologists. Anesthesiology. 1982 Dec; 57(6):504-18.
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  122. Kissin I, McGee T. Hypnotic effect of thiopental-lidocaine combination in the rat. Anesthesiology. 1982 Oct; 57(4):311-3.
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  123. Kissin I, Kilpatrick JV. Effects of nifedipine on myocardial energy balance in experimental coronary vasoconstriction and occlusion. J Cardiovasc Pharmacol. 1982 Jan-Feb; 4(1):111-5.
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  124. Kissin I, McGee T, Smith LR. The indices of potency for intravenous anaesthetics. Can Anaesth Soc J. 1981 Nov; 28(6):585-90.
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  125. Kissin I, Cavender JB. Effect of propranolol on energy demand -- supply balance in myocardial ischemia. J Cardiovasc Pharmacol. 1981 Sep-Oct; 3(5):992-1001.
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  126. Reves JG, Kissin I, Smith LR. The effective dose of midazolam. Anesthesiology. 1981 Jul; 55(1):82.
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  127. Kissin I, Stanbridge R, Bishop SP, Reves JG. Effect of halothane on myocardial infarct size in rats. Can Anaesth Soc J. 1981 May; 28(3):239-43.
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  128. Kissin I. Bioassay, potency, and intravenous anesthetics. Anesthesiology. 1980 Oct; 53(4):351-3.
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  129. Kissin I. Diazepam anesthesia and myocardial contractility. Anesthesiology. 1980 Jul; 53(1):78.
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  130. Kissin I, Reves JG, Mardis M. Is the rate-pressure product a misleading guide? Anesthesiology. 1980 Apr; 52(4):373-4.
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