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Keywords
Last Name
Institution

William Waiman Chin, M.D.

TitleExecutive Dean for Research
InstitutionHarvard Medical School
DepartmentBasic Sciences and Graduate Studies
AddressHarvard Medical School
Gordon Hall- Executive Dean for Research
25 Shattuck St
Boston MA 02115
Phone617/432-3638
Fax617/432-7494
Other Positions
TitleBertarelli Professor of Translational Medical Science
InstitutionBrigham and Women's Hospital
DepartmentMedicine
DivisionEndocrinology


 Mentoring 
 completed student projects
Optimizing the Role of Academia in Regulatory Science
Summer, 07/02/12 - 08/24/12

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Munos BH, Chin WW. How to revive breakthrough innovation in the pharmaceutical industry. Sci Transl Med. 2011 Jun 29; 3(89):89cm16.
    View in: PubMed
  2. Na S, Ma Y, Zhao J, Schmidt C, Zeng QQ, Chandrasekhar S, Chin WW, Nagpal S. A Nonsecosteroidal Vitamin D Receptor Modulator Ameliorates Experimental Autoimmune Encephalomyelitis without Causing Hypercalcemia. Autoimmune Dis. 2011; 2011:132958.
    View in: PubMed
  3. Lee LS, Thong PS, Olivo M, Chin WW, Ramaswamy B, Kho KW, Lim PL, Lau WK. Chlorin e6-polyvinylpyrrolidone mediated photodynamic therapy--A potential bladder sparing option for high risk non-muscle invasive bladder cancer. Photodiagnosis Photodyn Ther. 2010 Dec; 7(4):213-20.
    View in: PubMed
  4. Chin WW, Praveen T, Heng PW, Olivo M. Effect of polyvinylpyrrolidone on the interaction of chlorin e6 with plasma proteins and its subcellular localization. Eur J Pharm Biopharm. 2010 Oct; 76(2):245-52.
    View in: PubMed
  5. Munos BH, Chin WW. A call for sharing: adapting pharmaceutical research to new realities. Sci Transl Med. 2009 Dec 2; 1(9):9cm8.
    View in: PubMed
  6. Thong PS, Olivo M, Chin WW, Bhuvaneswari R, Mancer K, Soo KC. Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions. Br J Cancer. 2009 Nov 3; 101(9):1580-4.
    View in: PubMed
  7. Chin WW, Thong PS, Bhuvaneswari R, Soo KC, Heng PW, Olivo M. In-vivo optical detection of cancer using chlorin e6--polyvinylpyrrolidone induced fluorescence imaging and spectroscopy. BMC Med Imaging. 2009; 9:1.
    View in: PubMed
  8. Chin WW, Heng PW, Lim PL, Lau WK, Olivo M. Membrane transport enhancement of chlorin e6-polyvinylpyrrolidone and its photodynamic efficacy on the chick chorioallantoic model. J Biophotonics. 2008 Oct; 1(5):395-407.
    View in: PubMed
  9. Bhuvaneswari R, Gan YY, Lucky SS, Chin WW, Ali SM, Soo KC, Olivo M. Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy. Mol Cancer. 2008; 7:56.
    View in: PubMed
  10. Chin WW, Heng PW, Thong PS, Bhuvaneswari R, Hirt W, Kuenzel S, Soo KC, Olivo M. Improved formulation of photosensitizer chlorin e6 polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer. Eur J Pharm Biopharm. 2008 Aug; 69(3):1083-93.
    View in: PubMed
  11. Thong PS, Olivo M, Kho KW, Bhuvaneswari R, Chin WW, Ong KW, Soo KC. Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy. J Environ Pathol Toxicol Oncol. 2008; 27(1):35-42.
    View in: PubMed
  12. Chin WW, Heng PW, Olivo M. Chlorin e6 - polyvinylpyrrolidone mediated photosensitization is effective against human non-small cell lung carcinoma compared to small cell lung carcinoma xenografts. BMC Pharmacol. 2007; 7:15.
    View in: PubMed
  13. Fu CY, Ng BK, Razul SG, Chin WW, Tan PH, Lau WK, Olivo M. Fluorescence detection of bladder cancer using urine cytology. Int J Oncol. 2007 Sep; 31(3):525-30.
    View in: PubMed
  14. Saw CL, Olivo M, Chin WW, Soo KC, Heng PW. Superiority of N-methyl pyrrolidone over albumin with hypericin for fluorescence diagnosis of human bladder cancer cells implanted in the chick chorioallantoic membrane model. J Photochem Photobiol B. 2007 Mar 1; 86(3):207-18.
    View in: PubMed
  15. Chin WW, Heng PW, Bhuvaneswari R, Lau WK, Olivo M. The potential application of chlorin e6-polyvinylpyrrolidone formulation in photodynamic therapy. Photochem Photobiol Sci. 2006 Nov; 5(11):1031-7.
    View in: PubMed
  16. Chin WW, Lau WK, Heng PW, Bhuvaneswari R, Olivo M. Fluorescence imaging and phototoxicity effects of new formulation of chlorin e6-polyvinylpyrrolidone. J Photochem Photobiol B. 2006 Aug 1; 84(2):103-10.
    View in: PubMed
  17. Ma Y, Khalifa B, Yee YK, Lu J, Memezawa A, Savkur RS, Yamamoto Y, Chintalacharuvu SR, Yamaoka K, Stayrook KR, Bramlett KS, Zeng QQ, Chandrasekhar S, Yu XP, Linebarger JH, Iturria SJ, Burris TP, Kato S, Chin WW, Nagpal S. Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators. J Clin Invest. 2006 Apr; 116(4):892-904.
    View in: PubMed
  18. Chin WW, Lau WK, Bhuvaneswari R, Heng PW, Olivo M. Chlorin e6-polyvinylpyrrolidone as a fluorescent marker for fluorescence diagnosis of human bladder cancer implanted on the chick chorioallantoic membrane model. Cancer Lett. 2007 Jan 8; 245(1-2):127-33.
    View in: PubMed
  19. Olivo M, Chin W. Perylenequinones in photodynamic therapy: cellular versus vascular response. J Environ Pathol Toxicol Oncol. 2006; 25(1-2):223-37.
    View in: PubMed
  20. Iwasaki T, Takeshita A, Miyazaki W, Chin WW, Koibuchi N. The interaction of TRbeta1-N terminus with steroid receptor coactivator-1 (SRC-1) serves a full transcriptional activation function of SRC-1. Endocrinology. 2006 Mar; 147(3):1452-7.
    View in: PubMed
  21. Perry WL, Shepard RL, Sampath J, Yaden B, Chin WW, Iversen PW, Jin S, Lesoon A, O'Brien KA, Peek VL, Rolfe M, Shyjan A, Tighe M, Williamson M, Krishnan V, Moore RE, Dantzig AH. Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. Cancer Res. 2005 Aug 1; 65(15):6593-600.
    View in: PubMed
  22. Saw CL, Heng PW, Chin WW, Soo KC, Olivo M. Enhanced photodynamic activity of hypericin by penetration enhancer N-methyl pyrrolidone formulations in the chick chorioallantoic membrane model. Cancer Lett. 2006 Jul 8; 238(1):104-10.
    View in: PubMed
  23. Ramaswamy B, Manivasager V, Chin WW, Soo KC, Olivo M. Photodynamic diagnosis of a human nasopharyngeal carcinoma xenograft model using the novel Chlorin e6 photosensitizer Fotolon. Int J Oncol. 2005 Jun; 26(6):1501-6.
    View in: PubMed
  24. Saw CL, Olivo M, Chin WW, Soo KC, Heng PW. Transport of hypericin across chick chorioallantoic membrane and photodynamic therapy vasculature assessment. Biol Pharm Bull. 2005 Jun; 28(6):1054-60.
    View in: PubMed
  25. Gray SG, Iglesias AH, Lizcano F, Villanueva R, Camelo S, Jingu H, Teh BT, Koibuchi N, Chin WW, Kokkotou E, Dangond F. Functional characterization of JMJD2A, a histone deacetylase- and retinoblastoma-binding protein. J Biol Chem. 2005 Aug 5; 280(31):28507-18.
    View in: PubMed
  26. Iwasaki T, Koibuchi N, Chin WW. Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. Endocrinology. 2005 Sep; 146(9):3892-9.
    View in: PubMed
  27. Vasudevan N, Kia HK, Hadjimarkou M, Koibuchi N, Chin WW, Forrest D, Vennstrom B, Pfaff D. Retinoid-related receptor (ROR) alpha mRNA expression is altered in the brain of male mice lacking all ligand-binding thyroid hormone receptor (TR) isoforms. Endocrine. 2005 Feb; 26(1):25-32.
    View in: PubMed
  28. Chin W, Lau W, Lay SL, Wei KK, Olivo M. Photodynamic-induced vascular damage of the chick chorioallantoic membrane model using perylenequinones. Int J Oncol. 2004 Oct; 25(4):887-91.
    View in: PubMed
  29. Chin W, Lau W, Cheng C, Olivo M. Evaluation of Hypocrellin B in a human bladder tumor model in experimental photodynamic therapy: biodistribution, light dose and drug-light interval effects. Int J Oncol. 2004 Sep; 25(3):623-9.
    View in: PubMed
  30. Jeong KH, Chin WW, Kaiser UB. Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA. Mol Cell Biol. 2004 Jul; 24(14):6127-39.
    View in: PubMed
  31. Bettoun DJ, Lu J, Khalifa B, Yee Y, Chin WW, Nagpal S. Ligand modulates VDR-Ser/Thr protein phosphatase interaction and p70S6 kinase phosphorylation in a cell-context-dependent manner. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):195-8.
    View in: PubMed
  32. Bettoun DJ, Burris TP, Houck KA, Buck DW, Stayrook KR, Khalifa B, Lu J, Chin WW, Nagpal S. Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation. Mol Endocrinol. 2003 Nov; 17(11):2320-8.
    View in: PubMed
  33. Draper MW, Chin WW. Molecular and clinical evidence for the unique nature of individual selective estrogen receptor modulators. Clin Obstet Gynecol. 2003 Jun; 46(2):265-97.
    View in: PubMed
  34. Ko L, Chin WW. Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase. J Biol Chem. 2003 Mar 28; 278(13):11471-9.
    View in: PubMed
  35. Koibuchi N, Jingu H, Iwasaki T, Chin WW. Current perspectives on the role of thyroid hormone in growth and development of cerebellum. Cerebellum. 2003; 2(4):279-89.
    View in: PubMed
  36. Wu Y, Chin WW, Wang Y, Burris TP. Ligand and coactivator identity determines the requirement of the charge clamp for coactivation of the peroxisome proliferator-activated receptor gamma. J Biol Chem. 2003 Mar 7; 278(10):8637-44.
    View in: PubMed
  37. Thomas J, Bramlett KS, Montrose C, Foxworthy P, Eacho PI, McCann D, Cao G, Kiefer A, McCowan J, Yu KL, Grese T, Chin WW, Burris TP, Michael LF. A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor. J Biol Chem. 2003 Jan 24; 278(4):2403-10.
    View in: PubMed
  38. Delerive P, Chin WW, Suen CS. Identification of Reverb(alpha) as a novel ROR(alpha) target gene. J Biol Chem. 2002 Sep 20; 277(38):35013-8.
    View in: PubMed
  39. Bettoun DJ, Buck DW, Lu J, Khalifa B, Chin WW, Nagpal S. A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand. J Biol Chem. 2002 Jul 12; 277(28):24847-50.
    View in: PubMed
  40. Norwitz ER, Xu S, Jeong KH, Bédécarrats GY, Winebrenner LD, Chin WW, Kaiser UB. Activin A augments GnRH-mediated transcriptional activation of the mouse GnRH receptor gene. Endocrinology. 2002 Mar; 143(3):985-97.
    View in: PubMed
  41. Ko L, Cardona GR, Henrion-Caude A, Chin WW. Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors. Mol Cell Biol. 2002 Jan; 22(1):357-69.
    View in: PubMed
  42. Ko L, Cardona GR, Iwasaki T, Bramlett KS, Burris TP, Chin WW. Ser-884 adjacent to the LXXLL motif of coactivator TRBP defines selectivity for ERs and TRs. Mol Endocrinol. 2002 Jan; 16(1):128-40.
    View in: PubMed
  43. Wu Y, Delerive P, Chin WW, Burris TP. Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1. J Biol Chem. 2002 Mar 15; 277(11):8898-905.
    View in: PubMed
  44. Delerive P, Wu Y, Burris TP, Chin WW, Suen CS. PGC-1 functions as a transcriptional coactivator for the retinoid X receptors. J Biol Chem. 2002 Feb 8; 277(6):3913-7.
    View in: PubMed
  45. Vasudevan N, Koibuchi N, Chin WW, Pfaff DW. Differential crosstalk between estrogen receptor (ER)alpha and ERbeta and the thyroid hormone receptor isoforms results in flexible regulation of the consensus ERE. Brain Res Mol Brain Res. 2001 Nov 1; 95(1-2):9-17.
    View in: PubMed
  46. Vasudevan N, Davidkova G, Zhu YS, Koibuchi N, Chin WW, Pfaff D. Differential interaction of estrogen receptor and thyroid hormone receptor isoforms on the rat oxytocin receptor promoter leads to differences in transcriptional regulation. Neuroendocrinology. 2001 Nov; 74(5):309-24.
    View in: PubMed
  47. Chin WW. Message from the president of the American Thyroid Association. Thyroid. 2001 Sep; 11(9):811.
    View in: PubMed
  48. Vasudevan N, Zhu YS, Daniel S, Koibuchi N, Chin WW, Pfaff D. Crosstalk between oestrogen receptors and thyroid hormone receptor isoforms results in differential regulation of the preproenkephalin gene. J Neuroendocrinol. 2001 Sep; 13(9):779-90.
    View in: PubMed
  49. Kia HK, Krebs CJ, Koibuchi N, Chin WW, Pfaff DW. Co-expression of estrogen and thyroid hormone receptors in individual hypothalamic neurons. J Comp Neurol. 2001 Aug 27; 437(3):286-95.
    View in: PubMed
  50. Zhu YS, Cai LQ, You X, Duan Y, Imperato-McGinley J, Chin WW, Pfaff DW. Molecular analysis of estrogen induction of preproenkephalin gene expression and its modulation by thyroid hormones. Brain Res Mol Brain Res. 2001 Jul 13; 91(1-2):23-33.
    View in: PubMed
  51. Iwasaki T, Chin WW, Ko L. Identification and characterization of RRM-containing coactivator activator (CoAA) as TRBP-interacting protein, and its splice variant as a coactivator modulator (CoAM). J Biol Chem. 2001 Sep 7; 276(36):33375-83.
    View in: PubMed
  52. Kubin M, Cassiano L, Chalupny J, Chin W, Cosman D, Fanslow W, Müllberg J, Rousseau AM, Ulrich D, Armitage R. ULBP1, 2, 3: novel MHC class I-related molecules that bind to human cytomegalovirus glycoprotein UL16, activate NK cells. Eur J Immunol. 2001 May; 31(5):1428-37.
    View in: PubMed
  53. Koibuchi N, Yamaoka S, Chin WW. Effect of altered thyroid status on neurotrophin gene expression during postnatal development of the mouse cerebellum. Thyroid. 2001 Mar; 11(3):205-10.
    View in: PubMed
  54. Lizcano F, Koibuchi N, Fukuda H, Dangond F, Chin WW. Cell type-specific roles of histone deacetylase in TR ligand-independent transcriptional repression. Mol Cell Endocrinol. 2001 Feb 14; 172(1-2):13-20.
    View in: PubMed
  55. Eng PH, Cardona GR, Previti MC, Chin WW, Braverman LE. Regulation of the sodium iodide symporter by iodide in FRTL-5 cells. Eur J Endocrinol. 2001 Feb; 144(2):139-44.
    View in: PubMed
  56. Cosman D, Müllberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ. ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor. Immunity. 2001 Feb; 14(2):123-33.
    View in: PubMed
  57. Simoncini T, Hafezi-Moghadam A, Brazil DP, Ley K, Chin WW, Liao JK. Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase. Nature. 2000 Sep 28; 407(6803):538-41.
    View in: PubMed
  58. Kuno-Murata M, Koibuchi N, Fukuda H, Murata M, Chin WW. Augmentation of thyroid hormone receptor-mediated transcription by Ca2+/calmodulin-dependent protein kinase type IV. Endocrinology. 2000 Jun; 141(6):2275-8.
    View in: PubMed
  59. Ko L, Cardona GR, Chin WW. Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):6212-7.
    View in: PubMed
  60. Martinez de Arrieta C, Koibuchi N, Chin WW. Coactivator and corepressor gene expression in rat cerebellum during postnatal development and the effect of altered thyroid status. Endocrinology. 2000 May; 141(5):1693-8.
    View in: PubMed
  61. Koibuchi N, Chin WW. Thyroid hormone action and brain development. Trends Endocrinol Metab. 2000 May-Jun; 11(4):123-8.
    View in: PubMed
  62. Takeshita A, Ozawa Y, Chin WW. Nuclear receptor coactivators facilitate vitamin D receptor homodimer action on direct repeat hormone response elements. Endocrinology. 2000 Mar; 141(3):1281-4.
    View in: PubMed
  63. Zhang P, Chin W, Chow LT, Chan AS, Yim AP, Leung SF, Mok TS, Chang KS, Johnson PJ, Chan JY. Lack of expression for the suppressor PML in human small cell lung carcinoma. Int J Cancer. 2000 Mar 1; 85(5):599-605.
    View in: PubMed
  64. Huang W, Chan P, Chen Y, Chen C, Liao S, Chin W, Cheng J. Changes of superoxide dismutase in cultured rat aortic smooth muscle cells (A7r5) by an incubation of vitamin E. Pharmacology. 1999 Nov; 59(5):275-82.
    View in: PubMed
  65. Kubin MZ, Parshley DL, Din W, Waugh JY, Davis-Smith T, Smith CA, Macduff BM, Armitage RJ, Chin W, Cassiano L, Borges L, Petersen M, Trinchieri G, Goodwin RG. Molecular cloning and biological characterization of NK cell activation-inducing ligand, a counterstructure for CD48. Eur J Immunol. 1999 Nov; 29(11):3466-77.
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  66. Milne M, Kang MI, Cardona G, Quail JM, Braverman LE, Chin WW, Baran DT. Expression of multiple thyroid hormone receptor isoforms in rat femoral and vertebral bone and in bone marrow osteogenic cultures. J Cell Biochem. 1999 Sep 15; 74(4):684-93.
    View in: PubMed
  67. Koibuchi N, Fukuda H, Chin WW. Promoter-specific regulation of the brain-derived neurotropic factor gene by thyroid hormone in the developing rat cerebellum. Endocrinology. 1999 Sep; 140(9):3955-61.
    View in: PubMed
  68. Eng PH, Cardona GR, Fang SL, Previti M, Alex S, Carrasco N, Chin WW, Braverman LE. Escape from the acute Wolff-Chaikoff effect is associated with a decrease in thyroid sodium/iodide symporter messenger ribonucleic acid and protein. Endocrinology. 1999 Aug; 140(8):3404-10.
    View in: PubMed
  69. Norwitz ER, Jeong KH, Chin WW. Molecular mechanisms of gonadotropin-releasing hormone receptor gene regulation. J Soc Gynecol Investig. 1999 Jul-Aug; 6(4):169-78.
    View in: PubMed
  70. Albarracin CT, Frosch MP, Chin WW. The gonadotropin-releasing hormone receptor gene promoter directs pituitary-specific oncogene expression in transgenic mice. Endocrinology. 1999 May; 140(5):2415-21.
    View in: PubMed
  71. Juge-Aubry CE, Hammar E, Siegrist-Kaiser C, Pernin A, Takeshita A, Chin WW, Burger AG, Meier CA. Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain. J Biol Chem. 1999 Apr 9; 274(15):10505-10.
    View in: PubMed
  72. Misiti S, Koibuchi N, Bei M, Farsetti A, Chin WW. Expression of steroid receptor coactivator-1 mRNA in the developing mouse embryo: a possible role in olfactory epithelium development. Endocrinology. 1999 Apr; 140(4):1957-60.
    View in: PubMed
  73. Koibuchi N, Liu Y, Fukuda H, Takeshita A, Yen PM, Chin WW. ROR alpha augments thyroid hormone receptor-mediated transcriptional activation. Endocrinology. 1999 Mar; 140(3):1356-64.
    View in: PubMed
  74. Gu W, Tu Z, Kleyn PW, Kissebah A, Duprat L, Lee J, Chin W, Maruti S, Deng N, Fisher SL, Franco LS, Burn P, Yagaloff KA, Nathan J, Heymsfield S, Albu J, Pi-Sunyer FX, Allison DB. Identification and functional analysis of novel human melanocortin-4 receptor variants. Diabetes. 1999 Mar; 48(3):635-9.
    View in: PubMed
  75. Duncan KG, Jumper MD, Ribeiro RC, Bailey KR, Yen PM, Sugawara A, Patel A, Stern R, Chin WW, Baxter JD, Schwartz DM. Human trabecular meshwork cells as a thyroid hormone target tissue: presence of functional thyroid hormone receptors. Graefes Arch Clin Exp Ophthalmol. 1999 Mar; 237(3):231-40.
    View in: PubMed
  76. Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, Chin W, Jones J, Woodward A, Le T, Smith C, Smolak P, Goodwin RG, Rauch CT, Schuh JC, Lynch DH. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med. 1999 Feb; 5(2):157-63.
    View in: PubMed
  77. Ikeda M, Kawaguchi A, Takeshita A, Chin WW, Endo T, Onaya T. CBP-dependent and independent enhancing activity of steroid receptor coactivator-1 in thyroid hormone receptor-mediated transactivation. Mol Cell Endocrinol. 1999 Jan 25; 147(1-2):103-12.
    View in: PubMed
  78. Norwitz ER, Cardona GR, Jeong KH, Chin WW. Identification and characterization of the gonadotropin-releasing hormone response elements in the mouse gonadotropin-releasing hormone receptor gene. J Biol Chem. 1999 Jan 8; 274(2):867-80.
    View in: PubMed
  79. Halvorson LM, Kaiser UB, Chin WW. The protein kinase C system acts through the early growth response protein 1 to increase LHbeta gene expression in synergy with steroidogenic factor-1. Mol Endocrinol. 1999 Jan; 13(1):106-16.
    View in: PubMed
  80. Nagaya T, Murata Y, Yamaguchi S, Nomura Y, Ohmori S, Fujieda M, Katunuma N, Yen PM, Chin WW, Seo H. Intracellular proteolytic cleavage of 9-cis-retinoic acid receptor alpha by cathepsin L-type protease is a potential mechanism for modulating thyroid hormone action. J Biol Chem. 1998 Dec 11; 273(50):33166-73.
    View in: PubMed
  81. Hosler BA, Sapp PC, Berger R, O'Neill G, Bejaoui K, Hamida MB, Hentati F, Chin W, McKenna-Yasek D, Haines JL, Patterson D, Horvitz HR, Brown RH, Day CB. Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33. Neurogenetics. 1998 Dec; 2(1):34-42.
    View in: PubMed
  82. Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM. Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors. Endocrinology. 1998 Oct; 139(10):4197-204.
    View in: PubMed
  83. Takeshita A, Yen PM, Ikeda M, Cardona GR, Liu Y, Koibuchi N, Norwitz ER, Chin WW. Thyroid hormone response elements differentially modulate the interactions of thyroid hormone receptors with two receptor binding domains in the steroid receptor coactivator-1. J Biol Chem. 1998 Aug 21; 273(34):21554-62.
    View in: PubMed
  84. Halvorson LM, Ito M, Jameson JL, Chin WW. Steroidogenic factor-1 and early growth response protein 1 act through two composite DNA binding sites to regulate luteinizing hormone beta-subunit gene expression. J Biol Chem. 1998 Jun 12; 273(24):14712-20.
    View in: PubMed
  85. Chan JY, Chin W, Liew CT, Chang KS, Johnson PJ. Altered expression of the growth and transformation suppressor PML gene in human hepatocellular carcinomas and in hepatitis tissues. Eur J Cancer. 1998 Jun; 34(7):1015-22.
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  86. Kaiser UB, Sabbagh E, Chen MT, Chin WW, Saunders BD. Sp1 binds to the rat luteinizing hormone beta (LHbeta) gene promoter and mediates gonadotropin-releasing hormone-stimulated expression of the LHbeta subunit gene. J Biol Chem. 1998 May 22; 273(21):12943-51.
    View in: PubMed
  87. Misiti S, Schomburg L, Yen PM, Chin WW. Expression and hormonal regulation of coactivator and corepressor genes. Endocrinology. 1998 May; 139(5):2493-500.
    View in: PubMed
  88. Koibuchi N, Chin WW. ROR alpha gene expression in the perinatal rat cerebellum: ontogeny and thyroid hormone regulation. Endocrinology. 1998 May; 139(5):2335-41.
    View in: PubMed
  89. Kaiser UB, Sabbagh E, Saunders BD, Chin WW. Identification of cis-acting deoxyribonucleic acid elements that mediate gonadotropin-releasing hormone stimulation of the rat luteinizing hormone beta-subunit gene. Endocrinology. 1998 May; 139(5):2443-51.
    View in: PubMed
  90. Saunders BD, Sabbagh E, Chin WW, Kaiser UB. Differential use of signal transduction pathways in the gonadotropin-releasing hormone-mediated regulation of gonadotropin subunit gene expression. Endocrinology. 1998 Apr; 139(4):1835-43.
    View in: PubMed
  91. Ikeda M, Spanjaard RA, Noordhoek EW, Kawaguchi A, Onaya T, Chin WW. Ligand-inducible retinoid X receptor-mediated protein: DNA interactions in the retinoic acid receptor beta2 gene promoter in vivo. Mol Cell Endocrinol. 1998 Jan 15; 136(2):109-18.
    View in: PubMed
  92. Liu Y, Takeshita A, Nagaya T, Baniahmad A, Chin WW, Yen PM. An inhibitory region of the DNA-binding domain of thyroid hormone receptor blocks hormone-dependent transactivation. Mol Endocrinol. 1998 Jan; 12(1):34-44.
    View in: PubMed
  93. Siegrist-Kaiser CA, Pauli V, Juge-Aubry CE, Boss O, Pernin A, Chin WW, Cusin I, Rohner-Jeanrenaud F, Burger AG, Zapf J, Meier CA. Direct effects of leptin on brown and white adipose tissue. J Clin Invest. 1997 Dec 1; 100(11):2858-64.
    View in: PubMed
  94. Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW. TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1. J Biol Chem. 1997 Oct 31; 272(44):27629-34.
    View in: PubMed
  95. Scott RE, Wu-Peng XS, Yen PM, Chin WW, Pfaff DW. Interactions of estrogen- and thyroid hormone receptors on a progesterone receptor estrogen response element (ERE) sequence: a comparison with the vitellogenin A2 consensus ERE. Mol Endocrinol. 1997 Oct; 11(11):1581-92.
    View in: PubMed
  96. Ball SG, Sokolov J, Chin WW. 3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro. J Mol Endocrinol. 1997 Oct; 19(2):137-47.
    View in: PubMed
  97. Ball SG, Ikeda M, Chin WW. Deletion of the thyroid hormone beta1 receptor increases basal and triiodothyronine-induced growth hormone messenger ribonucleic acid in GH3 cells. Endocrinology. 1997 Aug; 138(8):3125-32.
    View in: PubMed
  98. Cosman D, Fanger N, Borges L, Kubin M, Chin W, Peterson L, Hsu ML. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 1997 Aug; 7(2):273-82.
    View in: PubMed
  99. Spanjaard RA, Ikeda M, Lee PJ, Charpentier B, Chin WW, Eberlein TJ. Specific activation of retinoic acid receptors (RARs) and retinoid X receptors reveals a unique role for RARgamma in induction of differentiation and apoptosis of S91 melanoma cells. J Biol Chem. 1997 Jul 25; 272(30):18990-9.
    View in: PubMed
  100. Sanno N, Sugawara A, Teramoto A, Abe Y, Yen PM, Chin WW, Osamura RY. Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas. Neuroendocrinology. 1997 Apr; 65(4):299-306.
    View in: PubMed
  101. Kaiser UB, Jakubowiak A, Steinberger A, Chin WW. Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro. Endocrinology. 1997 Mar; 138(3):1224-31.
    View in: PubMed
  102. Kaiser UB, Conn PM, Chin WW. Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines. Endocr Rev. 1997 Feb; 18(1):46-70.
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  103. Yen PM, Liu Y, Palvimo JJ, Trifiro M, Whang J, Pinsky L, Jänne OA, Chin WW. Mutant and wild-type androgen receptors exhibit cross-talk on androgen-, glucocorticoid-, and progesterone-mediated transcription. Mol Endocrinol. 1997 Feb; 11(2):162-71.
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  104. Zhu YS, Yen PM, Chin WW, Pfaff DW. Estrogen and thyroid hormone interaction on regulation of gene expression. Proc Natl Acad Sci U S A. 1996 Oct 29; 93(22):12587-92.
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  105. Hosler BA, Nicholson GA, Sapp PC, Chin W, Orrell RW, de Belleroche JS, Esteban J, Hayward LJ, Mckenna-Yasek D, Yeung L, Cherryson AK, Dench JE, Wilton SD, Laing NG, Horvitz HR, Brown RH. Three novel mutations and two variants in the gene for Cu/Zn superoxide dismutase in familial amyotrophic lateral sclerosis. Neuromuscul Disord. 1996 Oct; 6(5):361-6.
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  106. Shalev A, Siegrist-Kaiser CA, Yen PM, Wahli W, Burger AG, Chin WW, Meier CA. The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. Endocrinology. 1996 Oct; 137(10):4499-502.
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  107. Ikeda M, Wilcox EC, Chin WW. Different DNA elements can modulate the conformation of thyroid hormone receptor heterodimer and its transcriptional activity. J Biol Chem. 1996 Sep 20; 271(38):23096-104.
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  108. Penabad JL, Bashey HM, Asa SL, Haddad G, Davis KD, Herbst AB, Gennarelli TA, Kaiser UB, Chin WW, Snyder PJ. Decreased follistatin gene expression in gonadotroph adenomas. J Clin Endocrinol Metab. 1996 Sep; 81(9):3397-403.
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  109. Zhao D, McCaffery P, Ivins KJ, Neve RL, Hogan P, Chin WW, Dräger UC. Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase. Eur J Biochem. 1996 Aug 15; 240(1):15-22.
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  110. Takeshita A, Yen PM, Misiti S, Cardona GR, Liu Y, Chin WW. Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. Endocrinology. 1996 Aug; 137(8):3594-7.
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  111. Chin WW. Citation for the 1996 Ernst Oppenheimer Memorial Award of The Endocrine Society to Keith L. Parker. Endocr Rev. 1996 Aug; 17(4):414-5.
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  112. Cohen DM, Gullans SR, Chin WW. Urea inducibility of egr-1 in murine inner medullary collecting duct cells is mediated by the serum response element and adjacent Ets motifs. J Biol Chem. 1996 May 31; 271(22):12903-8.
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  113. Leedman PJ, Stein AR, Chin WW, Rogers JT. Thyroid hormone modulates the interaction between iron regulatory proteins and the ferritin mRNA iron-responsive element. J Biol Chem. 1996 May 17; 271(20):12017-23.
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  114. Yen PM, Liu Y, Sugawara A, Chin WW. Vitamin D receptors repress basal transcription and exert dominant negative activity on triiodothyronine-mediated transcriptional activity. J Biol Chem. 1996 May 3; 271(18):10910-6.
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  115. Cohen DM, Gullans SR, Chin WW. Urea signaling in cultured murine inner medullary collecting duct (mIMCD3) cells involves protein kinase C, inositol 1,4,5-trisphosphate (IP3), and a putative receptor tyrosine kinase. J Clin Invest. 1996 Apr 15; 97(8):1884-9.
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  116. Jones KE, Brubaker JH, Chin WW. An alternative splice variant of the mouse TRH receptor mRNA is the major form expressed in the mouse pituitary gland. J Mol Endocrinol. 1996 Apr; 16(2):197-204.
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  117. Fernández-Vázquez G, Kaiser UB, Albarracin CT, Chin WW. Transcriptional activation of the gonadotropin-releasing hormone receptor gene by activin A. Mol Endocrinol. 1996 Apr; 10(4):356-66.
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  118. Halvorson LM, Kaiser UB, Chin WW. Stimulation of luteinizing hormone beta gene promoter activity by the orphan nuclear receptor, steroidogenic factor-1. J Biol Chem. 1996 Mar 22; 271(12):6645-50.
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  119. Chin WW, Yen PM. T3 or not T3--the slings and arrows of outrageous TR function. Endocrinology. 1996 Feb; 137(2):387-8.
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  120. Kastner P, Mark M, Leid M, Gansmuller A, Chin W, Grondona JM, Décimo D, Krezel W, Dierich A, Chambon P. Abnormal spermatogenesis in RXR beta mutant mice. Genes Dev. 1996 Jan 1; 10(1):80-92.
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  121. Kaiser UB, Sabbagh E, Katzenellenbogen RA, Conn PM, Chin WW. A mechanism for the differential regulation of gonadotropin subunit gene expression by gonadotropin-releasing hormone. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12280-4.
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  122. Hayashi Y, Weiss RE, Sarne DH, Yen PM, Sunthornthepvarakul T, Marcocci C, Chin WW, Refetoff S. Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-beta receptors? J Clin Endocrinol Metab. 1995 Nov; 80(11):3246-56.
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  123. Spanjaard RA, Nguyen VP, Chin WW. Repression of glucocorticoid receptor-mediated transcriptional activation by unliganded thyroid hormone receptor (TR) is TR isoform-specific. Endocrinology. 1995 Nov; 136(11):5084-92.
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  124. Yen PM, Sugawara A, Liu Y, Whang J, Chin WW. Factors that enhance Escherichia coli-expressed TR beta binding to T3 and DNA. Thyroid. 1995 Aug; 5(4):309-13.
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  125. Spanjaard RA, Sugawara A, Ikeda M, Chin WW. Evidence that retinoid X receptors mediate retinoid-dependent transcriptional activation of the retinoic acid receptor beta gene in S91 melanoma cells. J Biol Chem. 1995 Jul 21; 270(29):17429-36.
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  126. Mercer JE, Chin WW. Regulation of pituitary gonadotrophin gene expression. Hum Reprod Update. 1995 Jul; 1(4):363-84.
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  127. Yen PM, Wilcox EC, Hayashi Y, Refetoff S, Chin WW. Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants. Endocrinology. 1995 Jul; 136(7):2845-51.
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  128. Suen CS, Chin WW. A potential transcriptional adaptor(s) may be required in thyroid hormone-stimulated gene transcription in vitro. Endocrinology. 1995 Jun; 136(6):2776-83.
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  129. Rhee M, Ikeda M, Chin WW. Retinoid X receptor-alpha and apolipoprotein AI regulatory protein 1 differentially modulate 3,5,3'-triiodothyronine-induced transcription. Endocrinology. 1995 Jun; 136(6):2697-704.
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  130. Sugawara A, Yen PM, Qi Y, Lechan RM, Chin WW. Isoform-specific retinoid-X receptor (RXR) antibodies detect differential expression of RXR proteins in the pituitary gland. Endocrinology. 1995 Apr; 136(4):1766-74.
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  131. Leedman PJ, Stein AR, Chin WW. Regulated specific protein binding to a conserved region of the 3'-untranslated region of thyrotropin beta-subunit mRNA. Mol Endocrinol. 1995 Mar; 9(3):375-87.
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  132. Chin WW. Van Meter Award. Thyroid. 1995 Feb; 5(1):79.
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  133. Yen PM, Wilcox EC, Chin WW. Steroid hormone receptors selectively affect transcriptional activation but not basal repression by thyroid hormone receptors. Endocrinology. 1995 Feb; 136(2):440-5.
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  134. Albarracin CT, Kaiser UB, Chin WW. Isolation and characterization of the 5'-flanking region of the mouse gonadotropin-releasing hormone receptor gene. Endocrinology. 1994 Dec; 135(6):2300-6.
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  135. Stanislaus D, Janovick JA, Jennes L, Kaiser UB, Chin WW, Conn PM. Functional and morphological characterization of four cell lines derived from GH3 cells stably transfected with gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid. Endocrinology. 1994 Nov; 135(5):2220-7.
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  136. Ribeiro RC, Apriletti JW, Yen PM, Chin WW, Baxter JD. Heterodimerization and deoxyribonucleic acid-binding properties of a retinoid X receptor-related factor. Endocrinology. 1994 Nov; 135(5):2076-85.
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  137. Sugawara A, Yen PM, Chin WW. 9-cis retinoic acid regulation of rat growth hormone gene expression: potential roles of multiple nuclear hormone receptors. Endocrinology. 1994 Nov; 135(5):1956-62.
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  138. Yen PM, Chin WW. Molecular mechanisms of dominant negative activity by nuclear hormone receptors. Mol Endocrinol. 1994 Nov; 8(11):1450-4.
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  139. Cohen DM, Chin WW, Gullans SR. Hyperosmotic urea increases transcription and synthesis of Egr-1 in murine inner medullary collecting duct (mIMCD3) cells. J Biol Chem. 1994 Oct 14; 269(41):25865-70.
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  140. Ikeda M, Rhee M, Chin WW. Thyroid hormone receptor monomer, homodimer, and heterodimer (with retinoid-X receptor) contact different nucleotide sequences in thyroid hormone response elements. Endocrinology. 1994 Oct; 135(4):1628-38.
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  141. Kaiser UB, Katzenellenbogen RA, Conn PM, Chin WW. Evidence that signalling pathways by which thyrotropin-releasing hormone and gonadotropin-releasing hormone act are both common and distinct. Mol Endocrinol. 1994 Aug; 8(8):1038-48.
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  142. Leonard JL, Farwell AP, Yen PM, Chin WW, Stula M. Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells. Endocrinology. 1994 Aug; 135(2):548-55.
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  143. Kuphal D, Janovick JA, Kaiser UB, Chin WW, Conn PM. Stable transfection of GH3 cells with rat gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid results in expression of a receptor coupled to cyclic adenosine 3',5'-monophosphate-dependent prolactin release via a G-protein. Endocrinology. 1994 Jul; 135(1):315-20.
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  144. Beck-Peccoz P, Chatterjee VK, Chin WW, DeGroot LJ, Jameson JL, Nakamura H, Refetoff S, Usala SJ, Weintraub BD. Nomenclature of thyroid hormone receptor beta gene mutations in resistance to thyroid hormone: consensus statement from the First Workshop on Thyroid Hormone Resistance, 10-11 July 1993, Cambridge, UK. Clin Endocrinol (Oxf). 1994 May; 40(5):697-700.
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  145. Yen PM, Ikeda M, Wilcox EC, Brubaker JH, Spanjaard RA, Sugawara A, Chin WW. Half-site arrangement of hybrid glucocorticoid and thyroid hormone response elements specifies thyroid hormone receptor complex binding to DNA and transcriptional activity. J Biol Chem. 1994 Apr 29; 269(17):12704-9.
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  146. Beck-Peccoz P, Chatterjee VK, Chin WW, DeGroot LJ, Jameson JL, Nakamura H, Refetoff S, Usala SJ, Weintraub BD. Nomenclature of thyroid hormone receptor beta gene mutations in resistance to thyroid hormone. First workshop on thyroid hormone resistance, July 10-11, 1993, Cambridge, U.K. J Endocrinol Invest. 1994 Apr; 17(4):283-7.
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  147. Beck-Peccoz P, Chatterjee VK, Chin WW, DeGroot LJ, Jameson JL, Nakamura H, Refetoff S, Usala SJ, Weintraub BD. Nomenclature of thyroid hormone receptor beta-gene mutations in resistance to thyroid hormone: consensus statement from the first workshop on thyroid hormone resistance, July 10-11, 1993, Cambridge, United Kingdom. J Clin Endocrinol Metab. 1994 Apr; 78(4):990-3.
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  148. Beck-Peccoz P, Chatterjee VK, Chin WW, DeGroot LJ, Jameson JL, Nakamura H, Refetoff S, Usala SJ, Weintraub BD. Nomenclature of thyroid hormone receptor-beta gene mutations in resistance to thyroid hormone: consensus statement from the First Workshop on Thyroid Hormone Resistance, 10-11th July 1993, Cambridge, UK. Eur J Endocrinol. 1994 Apr; 130(4):426-8.
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  149. Kaiser UB, Dushkin H, Altherr MR, Beier DR, Chin WW. Chromosomal localization of the gonadotropin-releasing hormone receptor gene to human chromosome 4q13.1-q21.1 and mouse chromosome 5. Genomics. 1994 Apr; 20(3):506-8.
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  150. Spanjaard RA, Nguyen VP, Chin WW. Rat Rev-erbA alpha, an orphan receptor related to thyroid hormone receptor, binds to specific thyroid hormone response elements. Mol Endocrinol. 1994 Mar; 8(3):286-95.
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  151. Yen PM, Brubaker JH, Apriletti JW, Baxter JD, Chin WW. Roles of 3,5,3'-triiodothyronine and deoxyribonucleic acid binding on thyroid hormone receptor complex formation. Endocrinology. 1994 Mar; 134(3):1075-81.
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  152. Yen PM, Chin WW. New advances in understanding the molecular mechanisms of thyroid hormone action. Trends Endocrinol Metab. 1994 Mar; 5(2):65-72.
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  153. Jones KE, Brubaker JH, Chin WW. Evidence that phosphorylation events participate in thyroid hormone action. Endocrinology. 1994 Feb; 134(2):543-8.
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  154. Yen PM, Ikeda M, Brubaker JH, Forgione M, Sugawara A, Chin WW. Roles of v-erbA homodimers and heterodimers in mediating dominant negative activity by v-erbA. J Biol Chem. 1994 Jan 14; 269(2):903-9.
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  155. Suen CS, Yen PM, Chin WW. In vitro transcriptional studies of the roles of the thyroid hormone (T3) response elements and minimal promoters in T3-stimulated gene transcription. J Biol Chem. 1994 Jan 14; 269(2):1314-22.
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  156. Sugawara A, Yen PM, Apriletti JW, Ribeiro RC, Sacks DB, Baxter JD, Chin WW. Phosphorylation selectively increases triiodothyronine receptor homodimer binding to DNA. J Biol Chem. 1994 Jan 7; 269(1):433-7.
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  157. Chin WW. Molecular mechanisms of thyroid hormone action. Thyroid. 1994; 4(3):389-93.
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  158. Beck-Peccoz P, Chatterjee VK, Chin WW, DeGroot LJ, Jameson JL, Nakamura H, Refetoff S, Usala SJ, Weintraub BD. Nomenclature of thyroid hormone receptor beta gene mutations in resistance to thyroid hormone: consensus statement from the first workshop on thyroid hormone resistance, July 10-11th 1993, Cambridge, U.K. Thyroid. 1994; 4(1):135-7.
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  159. Koibuchi N, Gibbs RB, Jones KE, Yamaoka S, Chin WW, Pfaff DW, Suzuki M. Increase in c-erbA alpha 2 mRNA in the parvocellular region of the paraventricular nucleus of the hypothalamus following thyroidectomy in the adult male rat. Neurosci Lett. 1993 Dec 24; 164(1-2):159-62.
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  160. Yen PM, Sugawara A, Forgione M, Spanjaard RA, Macchia E, Cheng SY, Chin WW. Region-specific anti-thyroid hormone receptor (TR) antibodies detect changes in TR structure due to ligand-binding and dimerization. Mol Cell Endocrinol. 1993 Nov; 97(1-2):93-9.
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  161. Sugawara A, Yen PM, Darling DS, Chin WW. Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors. Endocrinology. 1993 Sep; 133(3):965-71.
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  162. Kaiser UB, Jakubowiak A, Steinberger A, Chin WW. Regulation of rat pituitary gonadotropin-releasing hormone receptor mRNA levels in vivo and in vitro. Endocrinology. 1993 Aug; 133(2):931-4.
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  163. Zhao D, Yang J, Jones KE, Gerald C, Suzuki Y, Hogan P, Chin WW, Tashjian AH. Molecular cloning of a complementary deoxyribonucleic acid encoding the thyrotropin-releasing hormone receptor and regulation of its messenger ribonucleic acid in rat GH cells. Endocrinology. 1993 Jun; 132(6):2658.
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  164. Kaiser UB, Chin WW. Regulation of follistatin messenger ribonucleic acid levels in the rat pituitary. J Clin Invest. 1993 Jun; 91(6):2523-31.
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  165. Darling DS, Carter RL, Yen PM, Welborn JM, Chin WW, Umeda PK. Different dimerization activities of alpha and beta thyroid hormone receptor isoforms. J Biol Chem. 1993 May 15; 268(14):10221-7.
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  166. Chin W, Lee VM, Archer MC. Evidence that the hepatotoxicity of N-nitrosodimethylamine in the rat is unrelated to DNA methylation. Chem Res Toxicol. 1993 May-Jun; 6(3):372-5.
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  167. Suen CS, Chin WW. Ligand-dependent, Pit-1/growth hormone factor-1 (GHF-1)-independent transcriptional stimulation of rat growth hormone gene expression by thyroid hormone receptors in vitro. Mol Cell Biol. 1993 Mar; 13(3):1719-27.
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  168. Jones KE, Yaffe BM, Chin WW. Regulation of thyroid hormone receptor beta-2 mRNA levels by retinoic acid. Mol Cell Endocrinol. 1993 Feb; 91(1-2):113-8.
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  169. Chin WW, Carr FE, Burnside J, Darling DS. Thyroid hormone regulation of thyrotropin gene expression. Recent Prog Horm Res. 1993; 48:393-414.
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  170. Spanjaard RA, Chin WW. Reconstitution of ligand-mediated glucocorticoid receptor activity by trans-acting functional domains. Mol Endocrinol. 1993 Jan; 7(1):12-6.
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  171. Hupart KH, Hodin RA, Lazar MA, Shapiro LE, Chin WW, Surks MI. c-erb-A mRNA correlates with T3-receptor levels in liver and pituitary of tumor rats. Thyroid. 1993; 3(1):55-8.
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  172. Kaiser UB, Zhao D, Cardona GR, Chin WW. Isolation and characterization of cDNAs encoding the rat pituitary gonadotropin-releasing hormone receptor. Biochem Biophys Res Commun. 1992 Dec 30; 189(3):1645-52.
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  173. Yen PM, Sugawara A, Chin WW. Triiodothyronine (T3) differentially affects T3-receptor/retinoic acid receptor and T3-receptor/retinoid X receptor heterodimer binding to DNA. J Biol Chem. 1992 Nov 15; 267(32):23248-52.
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  174. Yen PM, Sugawara A, Refetoff S, Chin WW. New insights on the mechanism(s) of the dominant negative effect of mutant thyroid hormone receptor in generalized resistance to thyroid hormone. J Clin Invest. 1992 Nov; 90(5):1825-31.
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  175. Zhao D, Yang J, Jones KE, Gerald C, Suzuki Y, Hogan PG, Chin WW, Tashjian AH. Molecular cloning of a complementary deoxyribonucleic acid encoding the thyrotropin-releasing hormone receptor and regulation of its messenger ribonucleic acid in rat GH cells. Endocrinology. 1992 Jun; 130(6):3529-36.
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  176. Kaiser UB, Lee BL, Carroll RS, Unabia G, Chin WW, Childs GV. Follistatin gene expression in the pituitary: localization in gonadotropes and folliculostellate cells in diestrous rats. Endocrinology. 1992 May; 130(5):3048-56.
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  177. Gordon MS, Chin WW, Shupnik MA. Regulation of angiotensinogen gene expression by estrogen. J Hypertens. 1992 Apr; 10(4):361-6.
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  178. Yen PM, Sunday ME, Darling DS, Chin WW. Isoform-specific thyroid hormone receptor antibodies detect multiple thyroid hormone receptors in rat and human pituitaries. Endocrinology. 1992 Mar; 130(3):1539-46.
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  179. Yen PM, Darling DS, Carter RL, Forgione M, Umeda PK, Chin WW. Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers. J Biol Chem. 1992 Feb 25; 267(6):3565-8.
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  180. Yen PM, Darling DS, Chin WW. Basal and thyroid hormone receptor auxiliary protein-enhanced binding of thyroid hormone receptor isoforms to native thyroid hormone response elements. Endocrinology. 1991 Dec; 129(6):3331-6.
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  181. Carroll RS, Kowash PM, Lofgren JA, Schwall RH, Chin WW. In vivo regulation of FSH synthesis by inhibin and activin. Endocrinology. 1991 Dec; 129(6):3299-304.
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  182. Childs GV, Taub K, Jones KE, Chin WW. Triiodothyronine receptor beta-2 messenger ribonucleic acid expression by somatotropes and thyrotropes: effect of propylthiouracil-induced hypothyroidism in rats. Endocrinology. 1991 Nov; 129(5):2767-73.
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  183. Sunday ME, Choi N, Spindel ER, Chin WW, Mark EJ. Gastrin-releasing peptide gene expression in small cell and large cell undifferentiated lung carcinomas. Hum Pathol. 1991 Oct; 22(10):1030-9.
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  184. Spanjaard RA, Darling DS, Chin WW. Ligand-binding and heterodimerization activities of a conserved region in the ligand-binding domain of the thyroid hormone receptor. Proc Natl Acad Sci U S A. 1991 Oct 1; 88(19):8587-91.
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  185. Carroll RS, Corrigan AZ, Vale W, Chin WW. Activin stabilizes follicle-stimulating hormone-beta messenger ribonucleic acid levels. Endocrinology. 1991 Oct; 129(4):1721-6.
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  186. Krane IM, Spindel ER, Chin WW. Thyroid hormone decreases the stability and the poly(A) tract length of rat thyrotropin beta-subunit messenger RNA. Mol Endocrinol. 1991 Apr; 5(4):469-75.
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  187. Showers MO, Darling DS, Kieffer GD, Chin WW. Isolation and characterization of a cDNA encoding a chicken beta thyroid hormone receptor. DNA Cell Biol. 1991 Apr; 10(3):211-21.
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  188. Jones KE, Chin WW. Differential regulation of thyroid hormone receptor messenger ribonucleic acid levels by thyrotropin-releasing hormone. Endocrinology. 1991 Apr; 128(4):1763-8.
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  189. Corrigan AZ, Bilezikjian LM, Carroll RS, Bald LN, Schmelzer CH, Fendly BM, Mason AJ, Chin WW, Schwall RH, Vale W. Evidence for an autocrine role of activin B within rat anterior pituitary cultures. Endocrinology. 1991 Mar; 128(3):1682-4.
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  190. Darling DS, Beebe JS, Burnside J, Winslow ER, Chin WW. 3,5,3'-triiodothyronine (T3) receptor-auxiliary protein (TRAP) binds DNA and forms heterodimers with the T3 receptor. Mol Endocrinol. 1991 Jan; 5(1):73-84.
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  191. Beebe JS, Darling DS, Chin WW. 3,5,3'-triiodothyronine receptor auxiliary protein (TRAP) enhances receptor binding by interactions within the thyroid hormone response element. Mol Endocrinol. 1991 Jan; 5(1):85-93.
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  192. Lazar MA, Chin WW. Nuclear thyroid hormone receptors. J Clin Invest. 1990 Dec; 86(6):1777-82.
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  193. Gharib SD, Leung PC, Carroll RS, Chin WW. Androgens positively regulate follicle-stimulating hormone beta-subunit mRNA levels in rat pituitary cells. Mol Endocrinol. 1990 Nov; 4(11):1620-6.
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  194. Chin WW. Genes and endocrine maladies. J Clin Endocrinol Metab. 1990 Oct; 71(4):790-1.
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  195. Steel JH, O'Halloran DJ, Jones PM, Van Noorden S, Chin WW, Bloom SR, Polak JM. Combined use of immunocytochemistry and in situ hybridization to study beta thyroid-stimulating hormone gene expression in pituitaries of hypothyroid rats. Mol Cell Probes. 1990 Oct; 4(5):385-96.
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  196. Lazar MA, Hodin RA, Cardona G, Chin WW. Gene expression from the c-erbA alpha/Rev-ErbA alpha genomic locus. Potential regulation of alternative splicing by opposite strand transcription. J Biol Chem. 1990 Aug 5; 265(22):12859-63.
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  197. Wierman ME, Gharib SD, Wang C, LaRovere JM, Badger TM, Chin WW. Divergent regulation of gonadotropin subunit mRNA levels by androgens in the female rat. Biol Reprod. 1990 Aug; 43(2):191-5.
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  198. Hsu DW, el-Azouzi M, Black PM, Chin WW, Hedley-Whyte ET, Kaplan LM. Estrogen increases galanin immunoreactivity in hyperplastic prolactin-secreting cells in Fisher 344 rats. Endocrinology. 1990 Jun; 126(6):3159-67.
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  199. Childs GV, Unabia G, Wierman ME, Gharib SD, Chin WW. Castration induces time-dependent changes in the follicle-stimulating hormone beta-subunit messenger ribonucleic acid-containing gonadotrope cell population. Endocrinology. 1990 Apr; 126(4):2205-13.
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  200. Lazar MA, Jones KE, Chin WW. Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone. DNA Cell Biol. 1990 Mar; 9(2):77-83.
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  201. Burnside J, Darling DS, Chin WW. A nuclear factor that enhances binding of thyroid hormone receptors to thyroid hormone response elements. J Biol Chem. 1990 Feb 15; 265(5):2500-4.
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  202. Gharib SD, Wierman ME, Shupnik MA, Chin WW. Molecular biology of the pituitary gonadotropins. Endocr Rev. 1990 Feb; 11(1):177-99.
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  203. Hodin RA, Lazar MA, Chin WW. Differential and tissue-specific regulation of the multiple rat c-erbA messenger RNA species by thyroid hormone. J Clin Invest. 1990 Jan; 85(1):101-5.
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  204. Catz-Biro L, Chin W, Archer MC, Pollanen MS, Hayes MA. Toxicity of N-nitrosodimethylamine, N-nitrosomethylbenzylamine, and 1,2-dimethylhydrazine in isolated rat hepatocytes. Toxicol Appl Pharmacol. 1990 Jan; 102(1):191-4.
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  205. Carroll RS, Corrigan AZ, Gharib SD, Vale W, Chin WW. Inhibin, activin, and follistatin: regulation of follicle-stimulating hormone messenger ribonucleic acid levels. Mol Endocrinol. 1989 Dec; 3(12):1969-76.
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  206. Shupnik MA, Ridgway EC, Chin WW. Molecular biology of thyrotropin. Endocr Rev. 1989 Nov; 10(4):459-75.
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  207. Lazar MA, Hodin RA, Chin WW. Human carboxyl-terminal variant of alpha-type c-erbA inhibits trans-activation by thyroid hormone receptors without binding thyroid hormone. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):7771-4.
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  208. Darling DS, Burnside J, Chin WW. Binding of thyroid hormone receptors to the rat thyrotropin-beta gene. Mol Endocrinol. 1989 Sep; 3(9):1359-68.
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  209. Haisenleder DJ, Ortolano GA, Dalkin AC, Paul SJ, Chin WW, Marshall JC. Gonadotrophin-releasing hormone regulation of gonadotrophin subunit gene expression: studies in tri-iodothyronine-suppressed rats. J Endocrinol. 1989 Jul; 122(1):117-25.
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  210. Hodin RA, Lazar MA, Chin WW. The pituitary-specific form of rat c-erbA is a biologically active thyroid hormone receptor. Curr Surg. 1989 Jul-Aug; 46(4):298-301.
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  211. Gharib SD, Roy A, Wierman ME, Chin WW. Isolation and characterization of the gene encoding the beta-subunit of rat follicle-stimulating hormone. DNA. 1989 Jun; 8(5):339-49.
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  212. Burnside J, Darling DS, Carr FE, Chin WW. Thyroid hormone regulation of the rat glycoprotein hormone alpha-subunit gene promoter activity. J Biol Chem. 1989 Apr 25; 264(12):6886-91.
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  213. Hodin RA, Lazar MA, Wintman BI, Darling DS, Koenig RJ, Larsen PR, Moore DD, Chin WW. Identification of a thyroid hormone receptor that is pituitary-specific. Science. 1989 Apr 7; 244(4900):76-9.
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  214. Carr FE, Shupnik MA, Burnside J, Chin WW. Thyrotropin-releasing hormone stimulates the activity of the rat thyrotropin beta-subunit gene promoter transfected into pituitary cells. Mol Endocrinol. 1989 Apr; 3(4):717-24.
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  215. Carr FE, Burnside J, Chin WW. Thyroid hormones regulate rat thyrotropin beta gene promoter activity expressed in GH3 cells. Mol Endocrinol. 1989 Apr; 3(4):709-16.
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  216. Shupnik MA, Gordon MS, Chin WW. Tissue-specific regulation of rat estrogen receptor mRNAs. Mol Endocrinol. 1989 Apr; 3(4):660-5.
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  217. Lazar MA, Hodin RA, Darling DS, Chin WW. A novel member of the thyroid/steroid hormone receptor family is encoded by the opposite strand of the rat c-erbA alpha transcriptional unit. Mol Cell Biol. 1989 Mar; 9(3):1128-36.
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  218. Shupnik MA, Gharib SD, Chin WW. Divergent effects of estradiol on gonadotropin gene transcription in pituitary fragments. Mol Endocrinol. 1989 Mar; 3(3):474-80.
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  219. Koenig RJ, Lazar MA, Hodin RA, Brent GA, Larsen PR, Chin WW, Moore DD. Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature. 1989 Feb 16; 337(6208):659-61.
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  220. Shupnik MA, Weinmann CM, Notides AC, Chin WW. An upstream region of the rat luteinizing hormone beta gene binds estrogen receptor and confers estrogen responsiveness. J Biol Chem. 1989 Jan 5; 264(1):80-6.
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  221. Shupnik MA, Chin WW, Ridgway EC. T3 regulation of TSH gene expression. Endocr Res. 1989; 15(4):579-99.
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  222. Wierman ME, Gharib SD, Chin WW. The structure and regulation of the pituitary gonadotrophin subunit genes. Baillieres Clin Endocrinol Metab. 1988 Nov; 2(4):869-89.
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  223. Burnside J, Buckland PR, Chin WW. Isolation and characterization of the gene encoding the alpha-subunit of the rat pituitary glycoprotein hormones. Gene. 1988 Oct 15; 70(1):67-74.
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  224. Lazar MA, Hodin RA, Darling DS, Chin WW. Identification of a rat c-erbA alpha-related protein which binds deoxyribonucleic acid but does not bind thyroid hormone. Mol Endocrinol. 1988 Oct; 2(10):893-901.
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  225. Kaplan LM, Gabriel SM, Koenig JI, Sunday ME, Spindel ER, Martin JB, Chin WW. Galanin is an estrogen-inducible, secretory product of the rat anterior pituitary. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7408-12.
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  226. Krane IM, Naylor SL, Helin-Davis D, Chin WW, Spindel ER. Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin. J Biol Chem. 1988 Sep 15; 263(26):13317-23.
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  227. Chin WW. Hormonal regulation of thyrotropin and gonadotropin gene expression. Clin Res. 1988 Sep; 36(5):484-93.
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  228. Carr FE, Chin WW. Differential thyroid hormone-regulated rat thyrotropin beta gene expression detected by blot hybridization. Mol Endocrinol. 1988 Aug; 2(8):667-73.
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  229. Sunday ME, Kaplan LM, Motoyama E, Chin WW, Spindel ER. Gastrin-releasing peptide (mammalian bombesin) gene expression in health and disease. Lab Invest. 1988 Jul; 59(1):5-24.
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  230. Wierman ME, Gharib SD, LaRovere JM, Badger TM, Chin WW. Selective failure of androgens to regulate follicle stimulating hormone beta messenger ribonucleic acid levels in the male rat. Mol Endocrinol. 1988 Jun; 2(6):492-8.
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  231. Lazar MA, Chin WW. Regulation of two c-erbA messenger ribonucleic acids in rat GH3 cells by thyroid hormone. Mol Endocrinol. 1988 Jun; 2(6):479-84.
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  232. Shupnik MA, Gharib SD, Chin WW. Estrogen suppresses rat gonadotropin gene transcription in vivo. Endocrinology. 1988 May; 122(5):1842-6.
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  233. Boado R, Chopra IJ, Huang TS, Chin WW, Wettstein FO. A study of pituitary thyrotropin, its subunits, and messenger ribonucleic acids in nonthyroidal illness. Metabolism. 1988 Apr; 37(4):395-9.
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  234. Sunday ME, Wolfe HJ, Roos BA, Chin WW, Spindel ER. Gastrin-releasing peptide gene expression in developing, hyperplastic, and neoplastic human thyroid C-cells. Endocrinology. 1988 Apr; 122(4):1551-8.
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  235. Kaplan LM, Spindel ER, Isselbacher KJ, Chin WW. Tissue-specific expression of the rat galanin gene. Proc Natl Acad Sci U S A. 1988 Feb; 85(4):1065-9.
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  236. Childs GV, Lloyd JM, Unabia G, Gharib SD, Wierman ME, Chin WW. Detection of luteinizing hormone beta messenger ribonucleic acid (RNA) in individual gonadotropes after castration: use of a new in situ hybridization method with a photobiotinylated complementary RNA probe. Mol Endocrinol. 1987 Dec; 1(12):926-32.
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  237. Spindel ER, Sunday ME, Hofler H, Wolfe HJ, Habener JF, Chin WW. Transient elevation of messenger RNA encoding gastrin-releasing peptide, a putative pulmonary growth factor in human fetal lung. J Clin Invest. 1987 Oct; 80(4):1172-9.
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  238. Gharib SD, Wierman ME, Badger TM, Chin WW. Sex steroid hormone regulation of follicle-stimulating hormone subunit messenger ribonucleic acid (mRNA) levels in the rat. J Clin Invest. 1987 Aug; 80(2):294-9.
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  239. Spindel ER, Eipper BA, Zilberberg MD, Mains RE, Chin WW. Cerulein mRNA and peptide alpha-amidation activity in the skin of Xenopus laevis: stimulation by norepinephrine. Gen Comp Endocrinol. 1987 Jul; 67(1):67-76.
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  240. Mirell CJ, Yanagisawa M, Lau R, Pekary AE, Chin WW, Hershman JM. Influence of thyroidal status on pituitary content of thyrotropin beta- and alpha-subunit, growth hormone, and prolactin messenger ribonucleic acids. Mol Endocrinol. 1987 Jun; 1(6):408-12.
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  241. Franklyn JA, Wood DF, Balfour NJ, Ramsden DB, Docherty K, Chin WW, Sheppard MC. Effect of hypothyroidism and thyroid hormone replacement in vivo on pituitary cytoplasmic concentrations of thyrotropin-beta and alpha-subunit messenger ribonucleic acids. Endocrinology. 1987 Jun; 120(6):2279-88.
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  242. Spindel ER, Zilberberg MD, Chin WW. Analysis of the gene and multiple messenger ribonucleic acids (mRNAs) encoding human gastrin-releasing peptide: alternate RNA splicing occurs in neural and endocrine tissue. Mol Endocrinol. 1987 Mar; 1(3):224-32.
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  243. Mine M, Tramontano D, Chin WW, Ingbar SH. Interleukin-1 stimulates thyroid cell growth and increases the concentration of the c-myc proto-oncogene mRNA in thyroid follicular cells in culture. Endocrinology. 1987 Mar; 120(3):1212-4.
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  244. Carr FE, Need LR, Chin WW. Isolation and characterization of the rat thyrotropin beta-subunit gene. Differential regulation of two transcriptional start sites by thyroid hormone. J Biol Chem. 1987 Jan 25; 262(3):981-7.
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  245. Chin WW, Carr FE. Thyroid hormone regulation of the rat thyrotropin beta-subunit gene. Horm Metab Res Suppl. 1987; 17:82-6.
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  246. Naylor SL, Sakaguchi AY, Spindel E, Chin WW. Human gastrin-releasing peptide gene is located on chromosome 18. Somat Cell Mol Genet. 1987 Jan; 13(1):87-91.
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  247. Lalley PA, Sakaguchi AY, Eddy RL, Honey NH, Bell GI, Shen LP, Rutter WJ, Jacobs JW, Heinrich G, Chin WW, et al. Mapping polypeptide hormone genes in the mouse: somatostatin, glucagon, calcitonin, and parathyroid hormone. Cytogenet Cell Genet. 1987; 44(2-3):92-7.
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  248. Mirell CJ, Lau R, Huaco M, Pekary AE, Chin WW, Hershman JM. Differential expression of thyrotropin hormone genes by GH3 cells and the normal rat pituitary. Mol Cell Endocrinol. 1986 Sep; 47(1-2):145-51.
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  249. Papavasiliou SS, Zmeili S, Khoury S, Landefeld TD, Chin WW, Marshall JC. Gonadotropin-releasing hormone differentially regulates expression of the genes for luteinizing hormone alpha and beta subunits in male rats. Proc Natl Acad Sci U S A. 1986 Jun; 83(11):4026-9.
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  250. Naylor SL, Sakaguchi AY, McDonald L, Todd S, Lalley PA, Shows TB, Chin WW. Mapping thyrotropin beta subunit gene in man and mouse. Somat Cell Mol Genet. 1986 May; 12(3):307-11.
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  251. Tramontano D, Chin WW, Moses AC, Ingbar SH. Thyrotropin and dibutyryl cyclic AMP increase levels of c-myc and c-fos mRNAs in cultured rat thyroid cells. J Biol Chem. 1986 Mar 25; 261(9):3919-22.
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  252. Gharib SD, Bowers SM, Need LR, Chin WW. Regulation of rat luteinizing hormone subunit messenger ribonucleic acids by gonadal steroid hormones. J Clin Invest. 1986 Feb; 77(2):582-9.
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  253. Chin WW, Gharib SD. Organization and expression of gonadotropin genes. Adv Exp Med Biol. 1986; 205:245-65.
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  254. Spindel ER, Zilberberg MD, Habener JF, Chin WW. Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides. Proc Natl Acad Sci U S A. 1986 Jan; 83(1):19-23.
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  255. Spratt DI, Chin WW, Ridgway EC, Crowley WF. Administration of low dose pulsatile gonadotropin-releasing hormone (GnRH) to GnRH-deficient men regulates free alpha-subunit secretion. J Clin Endocrinol Metab. 1986 Jan; 62(1):102-8.
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  256. Abbot SD, Docherty K, Roberts JL, Tepper MA, Chin WW, Clayton RN. Castration increases luteinizing hormone subunit messenger RNA levels in male rat pituitaries. J Endocrinol. 1985 Nov; 107(2):R1-4.
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  257. Carr FE, Ridgway EC, Chin WW. Rapid simultaneous measurement of rat alpha- and thyrotropin (TSH) beta-subunit messenger ribonucleic acids (mRNAs) by solution hybridization: regulation of TSH subunit mRNAs by thyroid hormones. Endocrinology. 1985 Sep; 117(3):1272-8.
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  258. Chin WW, Muccini JA, Shin L. Evidence for a single rat thyrotropin-beta-subunit gene: thyroidectomy increases its mRNA. Biochem Biophys Res Commun. 1985 May 16; 128(3):1152-8.
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  259. Shupnik MA, Chin WW, Habener JF, Ridgway EC. Transcriptional regulation of the thyrotropin subunit genes by thyroid hormone. J Biol Chem. 1985 Mar 10; 260(5):2900-3.
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  260. Chin WW, Shupnik MA, Ross DS, Habener JF, Ridgway EC. Regulation of the alpha and thyrotropin beta-subunit messenger ribonucleic acids by thyroid hormones. Endocrinology. 1985 Mar; 116(3):873-8.
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  261. Carr FE, Chin WW. Absence of detectable chorionic gonadotropin subunit messenger ribonucleic acids in the rat placenta throughout gestation. Endocrinology. 1985 Mar; 116(3):1151-7.
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  262. Jameson L, Chin WW, Hollenberg AN, Chang AS, Habener JF. The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence. J Biol Chem. 1984 Dec 25; 259(24):15474-80.
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  263. Spindel ER, Chin WW, Price J, Rees LH, Besser GM, Habener JF. Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A. 1984 Sep; 81(18):5699-703.
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  264. Ross DS, Downing MF, Chin WW, Ridgway EC. Discordant changes in pituitary concentrations of LH and TSH subunits following hormonal manipulation. Metabolism. 1984 Mar; 33(3):230-4.
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  265. Shupnik MA, Chin WW, Ross DS, Downing MF, Habener JF, Ridgway EC. Regulation by thyroxine of the mRNA encoding the alpha subunit of mouse thyrotropin. J Biol Chem. 1983 Dec 25; 258(24):15120-4.
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  266. Naylor SL, Chin WW, Goodman HM, Lalley PA, Grzeschik KH, Sakaguchi AY. Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse. Somatic Cell Genet. 1983 Nov; 9(6):757-70.
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  267. Ridgway EC, Kieffer JD, Ross DS, Downing M, Mover H, Chin WW. Mouse pituitary tumor line secreting only the alpha-subunit of the glycoprotein hormones: development from a thyrotropic tumor. Endocrinology. 1983 Nov; 113(5):1587-91.
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  268. Klibanski A, Milbury PE, Chin WW, Ridgway EC. Direct adrenergic stimulation of the release of thyrotropin and its subunits from the thyrotrope in vitro. Endocrinology. 1983 Oct; 113(4):1244-9.
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  269. Chin WW, Godine JE, Klein DR, Chang AS, Tan LK, Habener JF. Nucleotide sequence of the cDNA encoding the precursor of the beta subunit of rat lutropin. Proc Natl Acad Sci U S A. 1983 Aug; 80(15):4649-53.
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  270. Ross DS, Downing MF, Chin WW, Kieffer JD, Ridgway EC. Changes in tissue concentrations of thyrotropin, free thyrotropin beta, and alpha-subunits after thyroxine administration: comparison of mouse hypothyroid pituitary and thyrotropic tumors. Endocrinology. 1983 Jun; 112(6):2050-3.
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  271. Ridgway EC, Klibanski A, Martorana MA, Milbury P, Kieffer JD, Chin WW. The effect of somatostatin on the release of thyrotropin and its subunits from bovine anterior pituitary cells in vitro. Endocrinology. 1983 Jun; 112(6):1937-42.
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  272. Chin WW, Maizel JV, Habener JF. Difference in sizes of human compared to murine alpha-subunits of the glycoprotein hormones arises by four-codon gene deletion or insertion. Endocrinology. 1983 Feb; 112(2):482-5.
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  273. Ross DS, Downing MF, Chin WW, Kieffer JD, Ridgway EC. Divergent changes in murine pituitary concentration of free alpha- and thyrotropin beta-subunits in hypothyroidism and after thyroxine administration. Endocrinology. 1983 Jan; 112(1):187-93.
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  274. Godine JE, Chin WW, Habener JF. alpha Subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs. J Biol Chem. 1982 Jul 25; 257(14):8368-71.
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  275. Cataldo NA, Cooper DS, Chin WW, Maloof F, Ridgway EC. The effect of thyroid hormones on prolactin secretion by cultured bovine pituitary cells. Metabolism. 1982 Jun; 31(6):589-94.
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  276. Godine JE, Chin WW, Habener JF. Detection of two precursors to each of the subunits of human chorionic gonadotropin translated from placental mRNA in the wheat germ cell-free system. Biochem Biophys Res Commun. 1982 Jan 29; 104(2):463-73.
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  277. Chin WW, Kronenberg HM, Dee PC, Maloof F, Habener JF. Nucleotide sequence of the mRNA encoding the pre-alpha-subunit of mouse thyrotropin. Proc Natl Acad Sci U S A. 1981 Sep; 78(9):5329-33.
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  278. Jacobs JW, Goodman RH, Chin WW, Dee PC, Habener JF, Bell NH, Potts JT. Calcitonin messenger RNA encodes multiple polypeptides in a single precursor. Science. 1981 Jul 24; 213(4506):457-9.
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  279. Chin WW, Habener JF. Thyroid-stimulating hormone subunits: evidence from endoglycosidase-H cleavage for late presecretory glycosylation. Endocrinology. 1981 May; 108(5):1628-33.
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  280. Chin WW, Maloof F, Habener JF. Thyroid-stimulating hormone biosynthesis. Cellular processing, assembly, and release of subunits. J Biol Chem. 1981 Mar 25; 256(6):3059-66.
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  281. Godine JE, Chin WW, Habener JF. Cell-free synthesis and processing of the precursors to the subunits of luteinizing hormone. J Biol Chem. 1981 Mar 10; 256(5):2475-9.
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  282. Chin WW, Goodman RH, Jacobs JW, Wolfe HJ, Daniels GH, Habener JF. Medullary thyroid carcinoma identified by cell-free translation of tumor messenger ribonucleic acid in a patient with a neck mass and the syndrome of ectopic adrenocorticotropin. J Clin Endocrinol Metab. 1981 Mar; 52(3):572-5.
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  283. Chin WW, Maloof F, Martorana MA, Pierce JG, Ridgway EC. Production and release of thyrotropin and its subunits by monolayer cultures containing bovine anterior pituitary cells. Endocrinology. 1981 Feb; 108(2):387-94.
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  284. Ridgway EC, Cooper DS, Walker H, Daniels GH, Chin WW, Myers G, Maloof F. Therapy of primary hypothyroidism with L-triiodothyronine: discordant cardiac and pituitary responses. Clin Endocrinol (Oxf). 1980 Nov; 13(5):479-88.
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  285. Chin WW, Habener JF, Martorana MA, Keutmann HT, Kieffer JD, Maloof F. Thyroid-stimulating hormone: isolation and partial characterization of hormone and subunits from a mouse thyrotrope tumor. Endocrinology. 1980 Nov; 107(5):1384-92.
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  286. Goodman RH, Jacobs JW, Chin WW, Lund PK, Dee PC, Habener JF. Nucleotide sequence of a cloned structural gene coding for a precursor of pancreatic somatostatin. Proc Natl Acad Sci U S A. 1980 Oct; 77(10):5869-73.
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  287. Godine JE, Chin WW, Habener JF. Luteinizing and follicle-stimulating hormones. Cell-free translations of messenger RNAs coding for subunit precursors. J Biol Chem. 1980 Sep 25; 255(18):8780-3.
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  288. Ridgway EC, Kourides IA, Chin WW, Cooper DS, Maloof F. Augmentation of pituitary thyrotrophin response to thyrotrophin releasing hormone during subphysiological tri-iodothyroinine therapy in hypothyroidism. Clin Endocrinol (Oxf). 1979 Apr; 10(4):343-53.
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  289. Chin WW, Habener JF, Kieffer JD, Maloof F. Cell-free translation of the messenger RNA coding for the alpha subunit of thyroid-stimulating hormone. J Biol Chem. 1978 Nov 25; 253(22):7985-8.
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  290. Ishibashi M, Chin WW, Maizel JV. The polypeptides of adenovirus. IX. Partial purification of early proteins and observations on late proteins of type 5 adenovirus. Virology. 1977 Nov; 83(1):1-15.
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  291. Kim S, Lotlikar PD, Chin W, Magee PN. Protein bound carboxyl-methyl ester as a precursor of methanol formation during oxidation of dimethylnitrosamine in vitro. Cancer Lett. 1977 Mar; 2(4-5):279-84.
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  292. Chin WW, Maizel JV. The polypeptides of adenovirus. VIII. The enrichment of E3 (11,000) in the nuclear matrix fraction. Virology. 1977 Jan; 76(1):79-89.
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  293. Chin WW, Maizel JV. The polypeptides of adenovirus. VII. Further studies of early polypeptides in vivo and localization of E2 and E2A to the cell plasma membrane. Virology. 1976 Jun; 71(2):518-30.
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  294. Chin W, Schussler GC. Decreased serum free thyroxine concentration in patients treated with diphenylhydantoin. J Clin Endocrinol Metab. 1968 Feb; 28(2):181-6.
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