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Last Name
Institution

William A. Carlezon, PH.D.

TitleProfessor of Psychiatry
InstitutionMcLean Hospital
DepartmentPsychiatry
AddressMclean Hospital
Behavioral Genetics Lab, Mrc 217
115 Mill St
Belmont MA 02478
Phone617/855-2021
Fax617/855-2023

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Li Y, Meloni EG, Carlezon WA, Milad MR, Pitman RK, Nader K, Bolshakov VY. Learning and reconsolidation implicate different synaptic mechanisms. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):4798-803.
    View in: PubMed
  2. Carroll FI, Carlezon WA. Development of ? Opioid Receptor Antagonists. J Med Chem. 2013 Mar 28; 56(6):2178-95.
    View in: PubMed
  3. Muschamp JW, Carlezon WA. Roles of Nucleus Accumbens CREB and Dynorphin in Dysregulation of Motivation. Cold Spring Harb Perspect Med. 2013; 3(2).
    View in: PubMed
  4. McDougle CJ, Carlezon WA. Neuroinflammation and autism: toward mechanisms and treatments. Neuropsychopharmacology. 2013 Jan; 38(1):241-2.
    View in: PubMed
  5. Carlezon WA. Neuropsychopharmacology: the 2013 transition in leadership. Neuropsychopharmacology. 2013 Jan; 38(2):257-8.
    View in: PubMed
  6. Cho JH, Zushida K, Shumyatsky GP, Carlezon WA, Meloni EG, Bolshakov VY. Pituitary adenylate cyclase-activating polypeptide induces postsynaptically expressed potentiation in the intra-amygdala circuit. J Neurosci. 2012 Oct 10; 32(41):14165-77.
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  7. Murphy BL, Stoll AL, Harris PQ, Ravichandran C, Babb SM, Carlezon WA, Cohen BM. Omega-3 fatty acid treatment, with or without cytidine, fails to show therapeutic properties in bipolar disorder: a double-blind, randomized add-on clinical trial. J Clin Psychopharmacol. 2012 Oct; 32(5):699-703.
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  8. Van't Veer A, Yano JM, Carroll FI, Cohen BM, Carlezon WA. Corticotropin-Releasing Factor (CRF)-Induced Disruption of Attention in Rats Is Blocked by the ?-Opioid Receptor Antagonist JDTic. Neuropsychopharmacology. 2012 Dec; 37(13):2809-16.
    View in: PubMed
  9. Béguin C, Potter DN, Carlezon WA, Stöhr T, Cohen BM. Effects of the anticonvulsant lacosamide compared to valproate and lamotrigine on cocaine-enhanced reward in rats. Brain Res. 2012 Oct 15; 1479:44-51.
    View in: PubMed
  10. Reynolds LM, Engin E, Tantillo G, Lau HM, Muschamp JW, Carlezon WA, Rudolph U. Differential roles of GABA(A) receptor subtypes in benzodiazepine-induced enhancement of brain-stimulation reward. Neuropsychopharmacology. 2012 Oct; 37(11):2531-40.
    View in: PubMed
  11. Myers KM, Carlezon WA. Reply to: Maintaining Clinical Relevance: Considerations for the Future of Research into D-Cycloserine and Cue Exposure Therapy for Addiction. Biol Psychiatry. 2012 Dec 1; 72(11):e31-2.
    View in: PubMed
  12. John CS, Smith KL, Van't Veer A, Gompf HS, Carlezon WA, Cohen BM, Öngür D, Bechtholt-Gompf AJ. Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedonia. Neuropsychopharmacology. 2012 Oct; 37(11):2467-75.
    View in: PubMed
  13. Myers KM, Carlezon WA. D-cycloserine effects on extinction of conditioned responses to drug-related cues. Biol Psychiatry. 2012 Jun 1; 71(11):947-55.
    View in: PubMed
  14. Munro TA, Berry LM, Van't Veer A, Béguin C, Carroll FI, Zhao Z, Carlezon WA, Cohen BM. Long-acting ? opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity. BMC Pharmacol. 2012; 12:5.
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  15. Myers KM, Bechtholt-Gompf AJ, Coleman BR, Carlezon WA. Extinction of conditioned opiate withdrawal in rats in a two-chambered place conditioning apparatus. Nat Protoc. 2012 Mar; 7(3):517-26.
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  16. Cho JH, Bayazitov IT, Meloni EG, Myers KM, Carlezon WA, Zakharenko SS, Bolshakov VY. Coactivation of thalamic and cortical pathways induces input timing-dependent plasticity in amygdala. Nat Neurosci. 2012 Jan; 15(1):113-22.
    View in: PubMed
  17. Béguin C, Potuzak J, Xu W, Liu-Chen LY, Streicher JM, Groer CE, Bohn LM, Carlezon WA, Cohen BM. Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues. Bioorg Med Chem Lett. 2012 Jan 15; 22(2):1023-6.
    View in: PubMed
  18. Wong DL, Tai TC, Wong-Faull DC, Claycomb R, Meloni EG, Myers KM, Carlezon WA, Kvetnansky R. Epinephrine: a short- and long-term regulator of stress and development of illness : a potential new role for epinephrine in stress. Cell Mol Neurobiol. 2012 Jul; 32(5):737-48.
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  19. Muschamp JW, Nemeth CL, Robison AJ, Nestler EJ, Carlezon WA. ?FosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488. Biol Psychiatry. 2012 Jan 1; 71(1):44-50.
    View in: PubMed
  20. Muschamp JW, Van't Veer A, Carlezon WA. Tracking down the molecular substrates of stress: new roles for p38a MAPK and kappa-opioid receptors. Neuron. 2011 Aug 11; 71(3):383-5.
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  21. Melief EJ, Miyatake M, Carroll FI, Béguin C, Carlezon WA, Cohen BM, Grimwood S, Mitch CH, Rorick-Kehn L, Chavkin C. Duration of action of a broad range of selective ?-opioid receptor antagonists is positively correlated with c-Jun N-terminal kinase-1 activation. Mol Pharmacol. 2011 Nov; 80(5):920-9.
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  22. Potter DN, Damez-Werno D, Carlezon WA, Cohen BM, Chartoff EH. Repeated exposure to the ?-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity. Biol Psychiatry. 2011 Oct 15; 70(8):744-53.
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  23. Chartoff E, Sawyer A, Rachlin A, Potter D, Pliakas A, Carlezon WA. Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats. Neuropharmacology. 2012 Jan; 62(1):167-76.
    View in: PubMed
  24. Knoll AT, Muschamp JW, Sillivan SE, Ferguson D, Dietz DM, Meloni EG, Carroll FI, Nestler EJ, Konradi C, Carlezon WA. Kappa opioid receptor signaling in the basolateral amygdala regulates conditioned fear and anxiety in rats. Biol Psychiatry. 2011 Sep 1; 70(5):425-33.
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  25. Paine TA, Slipp LE, Carlezon WA. Schizophrenia-like attentional deficits following blockade of prefrontal cortex GABAA receptors. Neuropsychopharmacology. 2011 Jul; 36(8):1703-13.
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  26. Muschamp JW, Van't Veer A, Parsegian A, Gallo MS, Chen M, Neve RL, Meloni EG, Carlezon WA. Activation of CREB in the nucleus accumbens shell produces anhedonia and resistance to extinction of fear in rats. J Neurosci. 2011 Feb 23; 31(8):3095-103.
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  27. Bechtholt-Gompf AJ, Smith KL, John CS, Kang HH, Carlezon WA, Cohen BM, Ongür D. CD-1 and Balb/cJ mice do not show enduring antidepressant-like effects of ketamine in tests of acute antidepressant efficacy. Psychopharmacology (Berl). 2011 Jun; 215(4):689-95.
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  28. Smith KS, Meloni EG, Myers KM, Van't Veer A, Carlezon WA, Rudolph U. Reduction of fear-potentiated startle by benzodiazepines in C57BL/6J mice. Psychopharmacology (Berl). 2011 Feb; 213(4):697-706.
    View in: PubMed
  29. Myers KM, Carlezon WA, Davis M. Glutamate receptors in extinction and extinction-based therapies for psychiatric illness. Neuropsychopharmacology. 2011 Jan; 36(1):274-93.
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  30. Bechtholt-Gompf AJ, Walther HV, Adams MA, Carlezon WA, Ongür D, Cohen BM. Blockade of astrocytic glutamate uptake in rats induces signs of anhedonia and impaired spatial memory. Neuropsychopharmacology. 2010 Sep; 35(10):2049-59.
    View in: PubMed
  31. Carlezon WA, Miczek KA. Ascent of the kappa-opioid receptor in psychopharmacology. Psychopharmacology (Berl). 2010 Jun; 210(2):107-8.
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  32. Nemeth CL, Paine TA, Rittiner JE, Béguin C, Carroll FI, Roth BL, Cohen BM, Carlezon WA. Role of kappa-opioid receptors in the effects of salvinorin A and ketamine on attention in rats. Psychopharmacology (Berl). 2010 Jun; 210(2):263-74.
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  33. Myers KM, Carlezon WA. Extinction of drug- and withdrawal-paired cues in animal models: relevance to the treatment of addiction. Neurosci Biobehav Rev. 2010 Nov; 35(2):285-302.
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  34. Loweth JA, Singer BF, Baker LK, Wilke G, Inamine H, Bubula N, Alexander JK, Carlezon WA, Neve RL, Vezina P. Transient overexpression of alpha-Ca2+/calmodulin-dependent protein kinase II in the nucleus accumbens shell enhances behavioral responding to amphetamine. J Neurosci. 2010 Jan 20; 30(3):939-49.
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  35. Myers KM, Carlezon WA. D-cycloserine facilitates extinction of naloxone-induced conditioned place aversion in morphine-dependent rats. Biol Psychiatry. 2010 Jan 1; 67(1):85-7.
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  36. Ardayfio PA, Leung A, Park J, Hwang DY, Moran-Gates T, Choi YK, Carlezon WA, Tarazi FI, Kim KS. Pitx3-deficient aphakia mice display unique behavioral responses to psychostimulant and antipsychotic drugs. Neuroscience. 2010 Mar 17; 166(2):391-6.
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  37. Knoll AT, Carlezon WA. Dynorphin, stress, and depression. Brain Res. 2010 Feb 16; 1314:56-73.
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  38. Straub CJ, Carlezon WA, Rudolph U. Diazepam and cocaine potentiate brain stimulation reward in C57BL/6J mice. Behav Brain Res. 2010 Jan 5; 206(1):17-20.
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  39. Cunningham MG, Connor CM, Carlezon WA, Meloni E. Amygdalar GABAergic-rich neural grafts attenuate anxiety-like behavior in rats. Behav Brain Res. 2009 Dec 14; 205(1):146-53.
    View in: PubMed
  40. Carlezon WA, Béguin C, Knoll AT, Cohen BM. Kappa-opioid ligands in the study and treatment of mood disorders. Pharmacol Ther. 2009 Sep; 123(3):334-43.
    View in: PubMed
  41. Riccio A, Li Y, Moon J, Kim KS, Smith KS, Rudolph U, Gapon S, Yao GL, Tsvetkov E, Rodig SJ, Van't Veer A, Meloni EG, Carlezon WA, Bolshakov VY, Clapham DE. Essential role for TRPC5 in amygdala function and fear-related behavior. Cell. 2009 May 15; 137(4):761-72.
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  42. Pereira Do Carmo G, Stevenson GW, Carlezon WA, Negus SS. Effects of pain- and analgesia-related manipulations on intracranial self-stimulation in rats: further studies on pain-depressed behavior. Pain. 2009 Jul; 144(1-2):170-7.
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  43. Paine TA, Neve RL, Carlezon WA. Attention deficits and hyperactivity following inhibition of cAMP-dependent protein kinase within the medial prefrontal cortex of rats. Neuropsychopharmacology. 2009 Aug; 34(9):2143-55.
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  44. Paine TA, Carlezon WA. Effects of antipsychotic drugs on MK-801-induced attentional and motivational deficits in rats. Neuropharmacology. 2009 Mar; 56(4):788-97.
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  45. Carlezon WA, Chartoff E. Perspective: Progress on the study and treatment of depressive illness. Neuropsychopharmacology. 2009 May; 34(6):1361-2.
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  46. Dinieri JA, Nemeth CL, Parsegian A, Carle T, Gurevich VV, Gurevich E, Neve RL, Nestler EJ, Carlezon WA. Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens. J Neurosci. 2009 Feb 11; 29(6):1855-9.
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  47. Paine TA, Pohlman JM, Carlezon WA. Attention in the 5-choice serial reaction time task is disrupted by acute and chronic administration of MK-801 in rats. Neuropharmacology. 2009.
  48. Chartoff EH, Barhight MF, Mague SD, Sawyer AM, Carlezon WA. Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats. Psychopharmacology (Berl). 2009 Jun; 204(2):227-39.
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  49. Do Carmo GP, Folk JE, Rice KC, Chartoff E, Carlezon WA, Negus SS. The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats. Eur J Pharmacol. 2009 Feb 14; 604(1-3):58-65.
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  50. Chartoff EH, Papadopoulou M, MacDonald ML, Parsegian A, Potter D, Konradi C, Carlezon WA. Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue. Mol Pharmacol. 2009 Mar; 75(3):704-12.
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  51. Béguin C, Duncan KK, Munro TA, Ho DM, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM. Modification of the furan ring of salvinorin A: identification of a selective partial agonist at the kappa opioid receptor. Bioorg Med Chem. 2009 Feb 1; 17(3):1370-80.
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  52. Paine TA, Carlezon WA. Effects of GABAA receptor blockade within the medial prefrontal cortex on attention. Society for Neuroscience Abstracts. 2008.
  53. Meloni EG, Adams M, Reedy CL, Cohen BM, Carlezon WA. Potentiation of CRF-induced anxiety-like behavior by acute fluoxetine treatment. Society for Neuroscience Abstracts. 2008.
  54. Dow AL, Lin T, Patel T, Neve RL, Ongur D, Carlezon WA. Disruption of Sprouty2 function in the dorsal hippocampus produces antidepressant-like effects in rats. Society for Neuroscience Abstracts. 2008.
  55. Knoll AT, Carroll FI, Meloni EG, Carlezon WA. Anxiolytic-like effects of kappa opioid receptor antagonism in the central and basolateral amygdala in rats. Society for Neuroscience Abstracts. 2008.
  56. Muschamp JW, Nemeth C, Nestler EJ, Carlezon WA. Inducible elevation of ΔFosB in the basal forebrain enhances cocaine-induced facilitation of ICSS in mice. Society for Neuroscience Abstracts. 2008.
  57. Yap JJ, Chartoff EH, Hogenelst K, Carlezon WA, Miczek KA. Brief social defeat stress-induced sensitization and escalated cocaine self-administration: role of ERK-CREB signaling in the mesocorticolimbic dopamine system. Society for Neuroscience Abstracts. 2008.
  58. Sawyer A, Chartoff EH, Carlezon WA. Effect of intra-nucleus accumbens shell microinjections of AMPA and the AMPA receptor antagonist NBQX on locomotor activity and place conditioning. Society for Neuroscience Abstracts. 2008.
  59. Potter D, Roitman MF, Carlezon WA, Cohen BM, Chartoff EH. Biphasic effects of the kappa opioid receptor agonist salvinorin A on hedonic state. Society for Neuroscience Abstracts. 2008.
  60. Chen MC, Parsegian A, Carlezon WA. Effect of mesocorticolimbic microinjections of the kappa-opioid agonist U50,488 on intracranial self-stimulation in rats. Society for Neuroscience Abstracts. 2008.
  61. Renshaw PF, Parsegian A, Yang CK, Novero A, Yoon SJ, Lyoo IK, Cohen BM, Carlezon WA. Lovastatin potentiates the antidepressant efficacy of fluoxetine in rats. Pharmacol Biochem Behav. 2009 Mar; 92(1):88-92.
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  62. Tomasiewicz HC, Todtenkopf MS, Chartoff EH, Cohen BM, Carlezon WA. The kappa-opioid agonist U69,593 blocks cocaine-induced enhancement of brain stimulation reward. Biol Psychiatry. 2008 Dec 1; 64(11):982-8.
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  63. Carlezon WA, Thomas MJ. Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis. Neuropharmacology. 2009; 56 Suppl 1:122-32.
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  64. Kenny PJ, Chartoff E, Roberto M, Carlezon WA, Markou A. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala. Neuropsychopharmacology. 2009 Jan; 34(2):266-81.
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  65. Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, Berman KF, Blair J, Braff DL, Brown ES, Calabrese JR, Carlezon WA, Cook EH, Davidson RJ, Davis M, Desimone R, Drevets WC, Duman RS, Essock SM, Faraone SV, Freedman R, Friston KJ, Gelernter J, Geller B, Gill M, Gould E, Grace AA, Grillon C, Gueorguieva R, Hariri AR, Innis RB, Jones EG, Kleinman JE, Koob GF, Krystal AD, Leibenluft E, Levinson DF, Levitt PR, Lewis DA, Liberzon I, Lipska BK, Marder SR, Markou A, Mason GF, McDougle CJ, McEwen BS, McMahon FJ, Meaney MJ, Meltzer HY, Merikangas KR, Meyer-Lindenberg A, Mirnics K, Monteggia LM, Neumeister A, O'Brien CP, Owen MJ, Pine DS, Rapoport JL, Rauch SL, Robbins TW, Rosenbaum JF, Rosenberg DR, Ross CA, Rush AJ, Sackeim HA, Sanacora G, Schatzberg AF, Shaham Y, Siever LJ, Sunderland T, Tecott LH, Thase ME, Todd RD, Weissman MM, Yehuda R, Yoshikawa T, Young EA, McCandless R. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biol Psychiatry. 2008 Apr 15; 63(8):725-7.
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  66. Chartoff EH, Potter D, Damez-Werno D, Cohen BM, Carlezon WA. Exposure to the selective kappa-opioid receptor agonist salvinorin A modulates the behavioral and molecular effects of cocaine in rats. Neuropsychopharmacology. 2008 Oct; 33(11):2676-87.
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  67. Monteggia LM, Carlezon WA Jr, DiLeone RJ. Functional genomics and models of mental illness. Neurobiology of Mental Illness;Charney DS, Nestler EJ, editors. 2008; in press.
  68. Meloni EG, Reedy CL, Cohen BM, Carlezon WA. Activation of raphe efferents to the medial prefrontal cortex by corticotropin-releasing factor: correlation with anxiety-like behavior. Biol Psychiatry. 2008 May 1; 63(9):832-9.
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  69. Cunningham MG, Donalds RA, Carlezon WA, Hong S, Kim DS, Kim DW, Kim KS. Antidepressant effect of stem cell-derived monoaminergic grafts. Neuroreport. 2007 Oct 29; 18(16):1663-7.
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  70. Munro TA, Duncan KK, Xu W, Wang Y, Liu-Chen LY, Carlezon WA, Cohen BM, Béguin C. Standard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethers. Bioorg Med Chem. 2008 Feb 1; 16(3):1279-86.
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  71. Béguin C, Potter DN, Dinieri JA, Munro TA, Richards MR, Paine TA, Berry L, Zhao Z, Roth BL, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM. N-methylacetamide analog of salvinorin A: a highly potent and selective kappa-opioid receptor agonist with oral efficacy. J Pharmacol Exp Ther. 2008 Jan; 324(1):188-95.
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  72. Knoll AT, Meloni EG, Thomas JB, Carroll FI, Carlezon WA. Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in rats. J Pharmacol Exp Ther. 2007 Dec; 323(3):838-45.
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  73. Malanga CJ, Riday TT, Carlezon WA, Kosofsky BE. Prenatal exposure to cocaine increases the rewarding potency of cocaine and selective dopaminergic agonists in adult mice. Biol Psychiatry. 2008 Jan 15; 63(2):214-21.
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  74. Kang H, Carlezon WA Jr, Cohen B, Ongur D. Glial-specific lesions of the infralimbic prefrontal cortex are associated with depressive-like behaviors in mice. Society for Neuroscience Abstracts. 2007; 33.
  75. Dow AL, Lin T, Patel T, Neve RL, Ongur D, Carlezon WA Jr . Effects of Sprouty2 on cell proliferation in the hippocampus of adult rat brain. Society for Neuroscience Abstracts. 2007; 33.
  76. Knoll AT, Carroll FI, Meloni EG , Carlezon WA Jr . Anxiolytic-like effects of κ-opioid receptor antagonists in behavioral models of unlearned and learned fear in rats. Society for Neuroscience Abstracts. 2007; 33.
  77. Damez-Werno D, Potter D, Cohen BM, Carlezon WA Jr, Chartoff EH. Exposure to the highly selective kappa agonist salvinorin A modulates the behavioral and molecular effects of cocaine in rats. Society for Neuroscience Abstracts. 2007; 33.
  78. Nemeth CA, Paine TA, Munro T, Cohen BM, Carlezon WA Jr . Effects of the dissociative agents salvinorin A and ketamine on attention in the 5-choice serial reaction time task in Sprague-Dawley rats. Society for Neuroscience Abstracts. 2007; 33.
  79. Meloni EG, Reedy CR, Cohen BM, Carlezon WA Jr. Corticotropin-releasing factor (CRF) activates raphe efferents to the prefrontal cortex: behavioral and anatomical studies. Society for Neuroscience Abstracts. 2007; 33.
  80. Paine TA, Pohlman JM, Carlezon WA Jr . Acute and chronic MK-801 administration: models of the attentional deficits in schizophrenia?. Society for Neuroscience Abstracts. 2007; 33.
  81. Carlezon WA, Chartoff EH. Extreme chipping: addiction to a high-fat diet? Biol Psychiatry. 2007 May 1; 61(9):1019-20.
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  82. Cohen BM, Carlezon WA. Can't get enough of that dopamine. Am J Psychiatry. 2007 Apr; 164(4):543-6.
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  83. Roybal K, Theobold D, Graham A, DiNieri JA, Russo SJ, Krishnan V, Chakravarty S, Peevey J, Oehrlein N, Birnbaum S, Vitaterna MH, Orsulak P, Takahashi JS, Nestler EJ, Carlezon WA, McClung CA. Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6406-11.
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  84. Paine TA, Tomasiewicz HC, Zhang K, Carlezon WA. Sensitivity of the five-choice serial reaction time task to the effects of various psychotropic drugs in Sprague-Dawley rats. Biol Psychiatry. 2007 Sep 15; 62(6):687-93.
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  85. Ongür D, Pohlman J, Dow AL, Eisch AJ, Edwin F, Heckers S, Cohen BM, Patel TB, Carlezon WA. Electroconvulsive seizures stimulate glial proliferation and reduce expression of Sprouty2 within the prefrontal cortex of rats. Biol Psychiatry. 2007 Sep 1; 62(5):505-12.
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  86. Munro TA, Duncan KK, Staples RJ, Xu W, Liu-Chen LY, Béguin C, Carlezon WA, Cohen BM. 8-epi-Salvinorin B: crystal structure and affinity at the kappa opioid receptor. Beilstein J Org Chem. 2007; 3:1.
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  87. Carlezon WA, Chartoff EH. Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation. Nat Protoc. 2007; 2(11):2987-95.
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  88. Carlezon WA Jr, Cohen BM. Potential Utility of Kappa Ligands in the Treatment of Mood Disorders. Opioid Receptors and Antagonists: From Bench to Clinic. R.L. Dean III, E.J. Bilsky, and S.S. Negus III, eds. 2007; (in press).
  89. Todtenkopf MS, Parsegian A, Naydenov A, Neve RL, Konradi C, Carlezon WA. Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell. J Neurosci. 2006 Nov 8; 26(45):11665-9.
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  90. Tegeder I, Costigan M, Griffin RS, Abele A, Belfer I, Schmidt H, Ehnert C, Nejim J, Marian C, Scholz J, Wu T, Allchorne A, Diatchenko L, Binshtok AM, Goldman D, Adolph J, Sama S, Atlas SJ, Carlezon WA, Parsegian A, Lötsch J, Fillingim RB, Maixner W, Geisslinger G, Max MB, Woolf CJ. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med. 2006 Nov; 12(11):1269-77.
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  91. Black YD, Maclaren FR, Naydenov AV, Carlezon WA, Baxter MG, Konradi C. Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence. J Neurosci. 2006 Sep 20; 26(38):9656-65.
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  92. Lee DY, He M, Liu-Chen LY, Wang Y, Li JG, Xu W, Ma Z, Carlezon WA, Cohen B. Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analogues. Bioorg Med Chem Lett. 2006 Nov 1; 16(21):5498-502.
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  93. Meloni EG, Jackson A, Gerety LP, Cohen BM, Carlezon WA. Role of the bed nucleus of the stria terminalis (BST) in the expression of conditioned fear. Ann N Y Acad Sci. 2006 Jul; 1071:538-41.
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  94. Chartoff EH, Mague SD, Barhight MF, Smith AM, Carlezon WA. Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. J Neurosci. 2006 Jun 14; 26(24):6450-7.
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  95. Béguin C, Richards MR, Li JG, Wang Y, Xu W, Liu-Chen LY, Carlezon WA, Cohen BM. Synthesis and in vitro evaluation of salvinorin A analogues: effect of configuration at C(2) and substitution at C(18). Bioorg Med Chem Lett. 2006 Sep 1; 16(17):4679-85.
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  96. Youngs RM, Chu MS, Meloni EG, Naydenov A, Carlezon WA, Konradi C. Lithium administration to preadolescent rats causes long-lasting increases in anxiety-like behavior and has molecular consequences. J Neurosci. 2006 May 31; 26(22):6031-9.
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  97. Tomasiewicz HC, Mague SD, Cohen BM, Carlezon WA. Behavioral effects of short-term administration of lithium and valproic acid in rats. Brain Res. 2006 Jun 6; 1093(1):83-94.
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  98. Meloni EG, Gerety LP, Knoll AT, Cohen BM, Carlezon WA. Behavioral and anatomical interactions between dopamine and corticotropin-releasing factor in the rat. J Neurosci. 2006 Apr 5; 26(14):3855-63.
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  99. Nestler EJ, Carlezon WA. The mesolimbic dopamine reward circuit in depression. Biol Psychiatry. 2006 Jun 15; 59(12):1151-9.
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  100. Todtenkopf MS, Carlezon WA. Contribution of drug doses and conditioning periods to psychomotor stimulant sensitization. Psychopharmacology (Berl). 2006 May; 185(4):451-8.
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  101. Borsook D, Becerra L, Carlezon WA, Shaw M, Renshaw P, Elman I, Levine J. Reward-aversion circuitry in analgesia and pain: implications for psychiatric disorders. Eur J Pain. 2007 Jan; 11(1):7-20.
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  102. Chartoff EH, Pliakas AM, Carlezon WA. Microinjection of the L-type calcium channel antagonist diltiazem into the ventral nucleus accumbens shell facilitates cocaine-induced conditioned place preferences. Biol Psychiatry. 2006 Jun 15; 59(12):1236-9.
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  103. Knoll AT, Carroll FI, Meloni EG, Konradi C, Carlezon WA Jr. Kappa opioid receptor antagonism produces anxiolytic-like behavioral effects in the elevated-plus maze. Society for Neuroscience Abstracts. 2006; 32.
  104. Meloni EG, Gerety LP, Cohen BM, Carlezon WA Jr. Effects of FG 7142 on the expression of fear-potentiated startle and CREF-enhanced startle in rats. Society for Neuroscience Abstracts. 2006; 32.
  105. Parsegian A, Todtenkopf MS, Neve RL, Carlezon WA Jr. Viral vector-induced elevations of CREB expression in the nucleus accumbens produces anhedonia in the rat intracranial self-stimulation (ICSS) test. Society for Neuroscience Abstracts. 2006; 32.
  106. Paine TA, Pohlman JM, Carlezon WA Jr. Activation of protein kinase A in the prefrontal cortex does not affect visuospatial attention in Sprague-Dawley rats. Society for Neuroscience Abstracts. 2006; 32.
  107. Chartoff EC, Barhight M, Carlezon WA Jr. Mesolimbic microinjections of a dopamine D1 receptor agonist: behavioral effects in morphine-dependent rats. Society for Neuroscience Abstracts. 2006; 32.
  108. Goussakov I, Chartoff EH, Tsvetkov E, Gerety LP, Meloni EG, Carlezon WA, Bolshakov VY. LTP in the lateral amygdala during cocaine withdrawal. Eur J Neurosci. 2006 Jan; 23(1):239-50.
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  109. Dow AL, Ongur D, Pohlman JM, Carlezon WA Jr. Effects of electroconvulsive seize (ECS) treatment on Sprouty-2 in adult rat brain. Society for Neuroscience Abstract. 2006; 32.
  110. DiNieri JA, Carle T, Nestler EJ, Carlezon WA Jr. Inducible disruption of CREB activity within nucleus accumbens alters sensitivity to rewarding and prodepressive drugs. Society for Neuroscience Abstracts. 2006; 32.
  111. Carlezon WA Jr. Treatment and screening methods for promoting neurogenesis. 2006.
  112. Carlezon WA, Béguin C, DiNieri JA, Baumann MH, Richards MR, Todtenkopf MS, Rothman RB, Ma Z, Lee DY, Cohen BM. Depressive-like effects of the kappa-opioid receptor agonist salvinorin A on behavior and neurochemistry in rats. J Pharmacol Exp Ther. 2006 Jan; 316(1):440-7.
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  113. Bonci A, Carlezon WA. Ion channels and intracellular signaling proteins as potential targets for novel therapeutics for addictive and depressive disorders. Pharmacol Ther. 2005 Oct; 108(1):65-75.
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  114. Lee DY, He M, Kondaveti L, Liu-Chen LY, Ma Z, Wang Y, Chen Y, Li JG, Beguin C, Carlezon WA, Cohen B. Synthesis and in vitro pharmacological studies of C(4) modified salvinorin A analogues. Bioorg Med Chem Lett. 2005 Oct 1; 15(19):4169-73.
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  115. Lee DY, Ma Z, Liu-Chen LY, Wang Y, Chen Y, Carlezon WA, Cohen B. New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human kappa opioid receptors. Bioorg Med Chem. 2005 Oct 1; 13(19):5635-9.
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  116. Neve RL, Neve KA, Nestler EJ, Carlezon WA. Use of herpes virus amplicon vectors to study brain disorders. Biotechniques. 2005 Sep; 39(3):381-91.
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  117. Lee DY, Karnati VV, He M, Liu-Chen LY, Kondaveti L, Ma Z, Wang Y, Chen Y, Beguin C, Carlezon WA, Cohen B. Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues. Bioorg Med Chem Lett. 2005 Aug 15; 15(16):3744-7.
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  118. Carlezon WA, Duman RS, Nestler EJ. The many faces of CREB. Trends Neurosci. 2005 Aug; 28(8):436-45.
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  119. Meloni EG, Jackson AV, Cohen BM, Carlezon WA. Corticotropin-releasing factor from the rat brain measured by protein immunoblot. Peptides. 2005 Nov; 26(11):2252-6.
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  120. Béguin C, Richards MR, Wang Y, Chen Y, Liu-Chen LY, Ma Z, Lee DY, Carlezon WA, Cohen BM. Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2). Bioorg Med Chem Lett. 2005 Jun 2; 15(11):2761-5.
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  121. Carlezon WA, Rohan ML, Mague SD, Meloni EG, Parsegian A, Cayetano K, Tomasiewicz HC, Rouse ED, Cohen BM, Renshaw PF. Antidepressant-like effects of cranial stimulation within a low-energy magnetic field in rats. Biol Psychiatry. 2005 Mar 15; 57(6):571-6.
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  122. Carlezon WA, Mague SD, Parow AM, Stoll AL, Cohen BM, Renshaw PF. Antidepressant-like effects of uridine and omega-3 fatty acids are potentiated by combined treatment in rats. Biol Psychiatry. 2005 Feb 15; 57(4):343-50.
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  123. Pandey SC, Chartoff EH, Carlezon WA, Zou J, Zhang H, Kreibich AS, Blendy JA, Crews FT. CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction. Alcohol Clin Exp Res. 2005 Feb; 29(2):176-84.
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  124. Mague SD, Andersen SL, Carlezon WA. Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in rats. Biol Psychiatry. 2005 Jan 15; 57(2):120-5.
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  125. Paine TA, Carlezon WA Jr. Inhibition of protein kinase A in the prefrontal cortex does not affect visuospatial attention, but reduces impulsivity in Sprague-Dawley rats. Society for Neuroscience Abstracts. 2005; 31.
  126. Pohlman JM, Ongur D, Eisch AJ, Edwin F, Heckers S, Cohen BM, Patel TB, Carlezon WA Jr. Electroconvulsive seizures stimulate cellular proliferation and reduce expression of Sprouty2 within the prefrontal cortex of rats. Society for Neuroscience Abstracts. 2005; 31.
  127. Todtenkopf MS, Carlezon WA Jr. Viral vector-mediated elevations of GluR1 in the nucleus accumbens shell reduce brain stimulation reward. Society for Neuroscience Abstracts. 2005; 31.
  128. Loweth J, Baker LK, Guillory AM, Guptaa T, Neve RL, Carlezon WA, Bayer KU, Vezina P. Viral-mediated overexpression of CaMKII enhances the locomotor response to amphetamine. Society for Neuroscience Abstracts. 2005; 31.
  129. DiNieri JA, Todtenkopf MS, Nestler EJ, Carlezon WA Jr. Cocaine-induced potentiation of brain stimulation reward is increased in mice expressing dominant negative CREB in the nucleus accumbens. Society for Neuroscience Abstracts. 2005; 31.
  130. Beguin C, Carlezon WA Jr, Lee D, Cohen BM. Salvinorin Derivatives and Uses Thereof. 2005.
  131. McClung CA, Theobold DE, Khatami AJ, DiNieri JA, Carlezon WA Jr, Vitaterna M, Takahashi JS, Nestler EJ. Disruption of the CLOCK gene in mice induces a manic-like state. Society for Neuroscience Abstracts. 2005; 31.
  132. Todtenkopf MS, Neve RL, Carlezon WA Jr. Brain stimulation reward thresholds are altered by viral vector-mediated elevations of GluR subunits within the nucleus accumbens shell. Neuropsychopharmacology. 2005; 30(Supplement 1):S217.
  133. Knoll AT, Gerety LP, Cohen BM, Carlezon WA Jr., Meloni EG. Behavioral effects of 6-hydroxydopamine lesions of the bed nucleus of the stria terminalis (BNST) measured with the fear-potentiated startle in rats. Society for Neuroscience Abstracts. 2005; 31.
  134. Cohen BM, Parsegian A, Ye N, Carlezon WA Jr. Prodepressant effects of the kappa opioid receptor agonist U-50488H are accompanied by alterations in Fos expression within the limbic system. Society for Neuroscience Abstracts. 2005; 31.
  135. Todtenkopf MS, Marcus JF, Portoghese PS, Carlezon WA. Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats. Psychopharmacology (Berl). 2004 Apr; 172(4):463-70.
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  136. Tomasiewicz HC, Meloni EG, Todtenkopf MS, Carlezon WA Jr. Depressive- and anxiogenic-like effects of a kappa-opioid receptor agonist as measured by intracranial self-stimulation and fear conditioning in rats. Society for Neuroscience Abstracts. 2004; 30.
  137. Chartoff EH, Mague SD, Smith AM, Carlezon WA Jr. Effects of microinjections of a dopamine D1 receptor agonist into the nucleus accumbens on precipitated opiate withdrawal-induced place conditioning in rats. Society for Neuroscience Abstracts. 2004; 30.
  138. Renshaw PF, Carlezon WA Jr, Cohen BM. Methods of Treating Psychiatric, Substance Abuse, and Other Disorders Using Combinations Containing Omega-3 Fatty Acids. 2004.
  139. Monteggia LM, Carlezon WA Jr, DiLeone RJ. Functional genomics and models of mental illness. Neurobiology of Mental Illness; Charney DS, Nestler EJ, editors. 2004; 87-100.
  140. Carlezon WA, Konradi C. Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules. Neuropharmacology. 2004; 47 Suppl 1:47-60.
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  141. Carlezon WA, Mague SD, Andersen SL. Enduring behavioral effects of early exposure to methylphenidate in rats. Biol Psychiatry. 2003 Dec 15; 54(12):1330-7.
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  142. Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA. Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitro. Ann N Y Acad Sci. 2003 Nov; 1003:368-71.
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  143. Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA. Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum. J Neurochem. 2003 Oct; 87(1):107-18.
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  144. Mague SD, Pliakas AM, Todtenkopf MS, Tomasiewicz HC, Zhang Y, Stevens WC, Jones RM, Portoghese PS, Carlezon WA. Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. J Pharmacol Exp Ther. 2003 Apr; 305(1):323-30.
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  145. Carlezon WA Jr. Treatment of Depression with Kappa Antagonists. 2003.
  146. Carlezon WA, Neve RL. Viral-mediated gene transfer to study the behavioral correlates of CREB function in the nucleus accumbens of rats. Methods Mol Med. 2003; 79:331-50.
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  147. Carlezon WA, Wise RA. Unmet expectations: the brain minds. Nat Med. 2003 Jan; 9(1):15-6.
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  148. Carlezon WA. Place conditioning to study drug reward and aversion. Methods Mol Med. 2003; 84:243-9.
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  149. Meloni EG, Jackson AV, Cohen BM, Carlezon WA Jr. Differential expression of phosphorylated cAMP response element binding protein (PCREB) in brain nuclei that mediate fear and anxiety in the rat. Society for Neuroscience Abstracts. 2003; 29.
  150. Pliakas AM, Papadopoulou M, Mague SD, Neve RL, Konradi C, Chartoff EH, Carlezon WA Jr. Effects of desipramine associated with decreased CREB function in rat nucleus accumbens and related tissues. Society for Neuroscience Abstracts. 2003; 29.
  151. Neumaier JF, Vincow ES, Arvanitogiannis A, Wise RA, Carlezon WA. Elevated expression of 5-HT1B receptors in nucleus accumbens efferents sensitizes animals to cocaine. J Neurosci. 2002 Dec 15; 22(24):10856-63.
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  152. Carlezon WA, Nestler EJ. Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse? Trends Neurosci. 2002 Dec; 25(12):610-5.
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  153. Kelsey JE, Carlezon WA. Prior experience with bromocriptine in the home cage attenuates locomotor sensitization in rats. Behav Brain Res. 2002 Aug 21; 134(1-2):1-8.
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  154. Gilliss B, Malanga CJ, Pieper JO, Carlezon WA. Cocaine and SKF-82958 potentiate brain stimulation reward in Swiss-Webster mice. Psychopharmacology (Berl). 2002 Sep; 163(2):238-48.
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  155. Carlezon WA, Pliakas AM, Parow AM, Detke MJ, Cohen BM, Renshaw PF. Antidepressant-like effects of cytidine in the forced swim test in rats. Biol Psychiatry. 2002 Jun 1; 51(11):882-9.
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  156. Tsvetkov E, Carlezon WA, Benes FM, Kandel ER, Bolshakov VY. Fear conditioning occludes LTP-induced presynaptic enhancement of synaptic transmission in the cortical pathway to the lateral amygdala. Neuron. 2002 Apr 11; 34(2):289-300.
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  157. Andersen SL, Arvanitogiannis A, Pliakas AM, LeBlanc C, Carlezon WA. Altered responsiveness to cocaine in rats exposed to methylphenidate during development. Nat Neurosci. 2002 Jan; 5(1):13-4.
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  158. Hwang DY, Carlezon WA, Isacson O, Kim KS. A high-efficiency synthetic promoter that drives transgene expression selectively in noradrenergic neurons. Hum Gene Ther. 2001 Sep 20; 12(14):1731-40.
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  159. Pliakas AM, Carlson RR, Neve RL, Konradi C, Nestler EJ, Carlezon WA. Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. J Neurosci. 2001 Sep 15; 21(18):7397-403.
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  160. Carlezon WA, Todtenkopf MS, McPhie DL, Pimentel P, Pliakas AM, Stellar JR, Trzcinska M. Repeated exposure to rewarding brain stimulation downregulates GluR1 expression in the ventral tegmental area. Neuropsychopharmacology. 2001 Aug; 25(2):234-41.
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  161. Josselyn SA, Shi C, Carlezon WA, Neve RL, Nestler EJ, Davis M. Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala. J Neurosci. 2001 Apr 1; 21(7):2404-12.
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  162. Neve RL, Carlezon WA Jr. Gene Delivery into the Brain Using Viral Vectors. Neuropsychopharmacology: The Fifth Generation of Progress. Davis KL, Charney D, Coyle JT, Nemeroff C, eds. 2001; 253-262.
  163. Carlezon WA, Kosten TA, Nestler EJ. Behavioral interactions caused by combined administration of morphine and MK-801 in rats. Psychopharmacology (Berl). 2000 Aug; 151(2-3):261-72.
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  164. Messer CJ, Eisch AJ, Carlezon WA, Whisler K, Shen L, Wolf DH, Westphal H, Collins F, Russell DS, Nestler EJ. Role for GDNF in biochemical and behavioral adaptations to drugs of abuse. Neuron. 2000 Apr; 26(1):247-57.
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  165. Carlezon WA, Haile CN, Coppersmith R, Hayashi Y, Malinow R, Neve RL, Nestler EJ. Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1. J Neurosci. 2000 Mar 1; 20(5):RC62.
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  166. Carlezon WA, Nestler EJ, Neve RL. Herpes simplex virus-mediated gene transfer as a tool for neuropsychiatric research. Crit Rev Neurobiol. 2000; 14(1):47-67.
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  167. Kelz MB, Chen J, Carlezon WA, Whisler K, Gilden L, Beckmann AM, Steffen C, Zhang YJ, Marotti L, Self DW, Tkatch T, Baranauskas G, Surmeier DJ, Neve RL, Duman RS, Picciotto MR, Nestler EJ. Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature. 1999 Sep 16; 401(6750):272-6.
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  168. Atkins JB, Chlan-Fourney J, Nye HE, Hiroi N, Carlezon WA, Nestler EJ. Region-specific induction of deltaFosB by repeated administration of typical versus atypical antipsychotic drugs. Synapse. 1999 Aug; 33(2):118-28.
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  169. Carlezon WA, Rasmussen K, Nestler EJ. AMPA antagonist LY293558 blocks the development, without blocking the expression, of behavioral sensitization to morphine. Synapse. 1999 Mar 15; 31(4):256-62.
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  170. Brodkin ES, Kosten TA, Haile CN, Heninger GR, Carlezon WA, Jatlow P, Remmers EF, Wilder RL, Nestler EJ. Dark Agouti and Fischer 344 rats: differential behavioral responses to morphine and biochemical differences in the ventral tegmental area. Neuroscience. 1999; 88(4):1307-15.
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  171. Carlezon WA, Thome J, Olson VG, Lane-Ladd SB, Brodkin ES, Hiroi N, Duman RS, Neve RL, Nestler EJ. Regulation of cocaine reward by CREB. Science. 1998 Dec 18; 282(5397):2272-5.
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  172. Brodkin ES, Carlezon WA, Haile CN, Kosten TA, Heninger GR, Nestler EJ. Genetic analysis of behavioral, neuroendocrine, and biochemical parameters in inbred rodents: initial studies in Lewis and Fischer 344 rats and in A/J and C57BL/6J mice. Brain Res. 1998 Sep 14; 805(1-2):55-68.
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  173. Carlezon WA, Boundy VA, Haile CN, Lane SB, Kalb RG, Neve RL, Nestler EJ. Sensitization to morphine induced by viral-mediated gene transfer. Science. 1997 Aug 8; 277(5327):812-4.
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  174. Carlezon WA, Wise RA. Microinjections of phencyclidine (PCP) and related drugs into nucleus accumbens shell potentiate medial forebrain bundle brain stimulation reward. Psychopharmacology (Berl). 1996 Dec; 128(4):413-20.
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  175. Carlezon WA, Wise RA. Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex. J Neurosci. 1996 May 1; 16(9):3112-22.
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  176. Wise RA, Mendrek A, Carlezon WA. MK-801 (dizocilpine): synergist and conditioned stimulus in bromocriptine-induced psychomotor sensitization. Synapse. 1996 Apr; 22(4):362-8.
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  177. Carlezon WA, Devine DP, Wise RA. Habit-forming actions of nomifensine in nucleus accumbens. Psychopharmacology (Berl). 1995 Nov; 122(2):194-7.
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  178. Carlezon WA, Mendrek A, Wise RA. MK-801 disrupts the expression but not the development of bromocriptine sensitization: a state-dependency interpretation. Synapse. 1995 May; 20(1):1-9.
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  179. Carlezon WA Jr. Substrates of the rewarding effects of phencyclidine (PCP) and related drugs. 1995.
  180. Wise RA, Carlezon WA. Attenuation of the locomotor-sensitizing effects of the D2 dopamine agonist bromocriptine by either the D1 antagonist SCH 23390 or the D2 antagonist raclopride. Synapse. 1994 Jul; 17(3):155-9.
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  181. Devine DP, Leone P, Carlezon WA, Wise RA. Ventral mesencephalic delta opioid receptors are involved in modulation of basal mesolimbic dopamine neurotransmission: an anatomical localization study. Brain Res. 1993 Sep 17; 622(1-2):348-52.
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  182. Carlezon WA, Wise RA. Morphine-induced potentiation of brain stimulation reward is enhanced by MK-801. Brain Res. 1993 Aug 27; 620(2):339-42.
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  183. Fishkin RJ, Ince ES, Carlezon WA, Dunn RW. D-cycloserine attenuates scopolamine-induced learning and memory deficits in rats. Behav Neural Biol. 1993 Mar; 59(2):150-7.
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  184. Carlezon WA, Wise RA. Phencyclidine-induced potentiation of brain stimulation reward: acute effects are not altered by repeated administration. Psychopharmacology (Berl). 1993; 111(4):402-8.
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  185. Wise RA, Bauco P, Carlezon WA, Trojniar W. Self-stimulation and drug reward mechanisms. Ann N Y Acad Sci. 1992 Jun 28; 654:192-8.
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  186. Carlezon WA Jr. PCP-induced potentiation of brain stimulation reward: acute effects are not altered by repeated administration. 1991.
  187. Dunn RW, Carlezon WA Jr, Corbett R. The preclinical anxiolytic versus antipsychotic profiles of the 5-HT3 antagonists ondansetron, zacopride, 3a-tropanyl-1H-indole-3-carboxylic acid ester, and 1aH, 3a 5aH-tropan-3-yl-3, 5-dichlorobenzoate. Drug Development Research. 1991; 23:289-300.
  188. Carlezon WA Jr, Cornfeldt ML, Szewczak MR, Fielding S, Dunn RW. Reversal of both QNX-induced locomotion and habituation decrement is indicative of M1 agonist properties. Drug Development Research. 1991; 23:333-339.
  189. Kelsey JE, Carlezon WA, Falls WA. Lesions of the nucleus accumbens in rats reduce opiate reward but do not alter context-specific opiate tolerance. Behav Neurosci. 1989 Dec; 103(6):1327-34.
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  190. Carlezon WA Jr. Separate neural systems of opiate reward and addiction. 1986.
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