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Alan F. Cowman, Ph.D.

TitleVisiting Scientist
InstitutionHarvard School of Public Health
DepartmentImmunology and Infectious Diseases
AddressHarvard School of Public Health
Bldg 1 RM 704
665 Huntington Ave
Boston MA 02115

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Boddey JA, Carvalho TG, Hodder AN, Sargeant TJ, Sleebs BE, Marapana D, Lopaticki S, Nebl T, Cowman AF. Role of Plasmepsin V in Export of Diverse Protein Families from the Plasmodium falciparum Exportome. Traffic. 2013 May; 14(5):532-50.
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  2. Riglar DT, Rogers KL, Hanssen E, Turnbull L, Bullen HE, Charnaud SC, Przyborski J, Gilson PR, Whitchurch CB, Crabb BS, Baum J, Cowman AF. Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes. Nat Commun. 2013 Jan 29; 4:1415.
    View in: PubMed
  3. Hill DL, Eriksson EM, Carmagnac AB, Wilson DW, Cowman AF, Hansen DS, Schofield L. Efficient Measurement of Opsonising Antibodies to Plasmodium falciparum Merozoites. PLoS One. 2012; 7(12):e51692.
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  4. Drew DR, Hodder AN, Wilson DW, Foley M, Mueller I, Siba PM, Dent AE, Cowman AF, Beeson JG. Defining the Antigenic Diversity of Plasmodium falciparum Apical Membrane Antigen 1 and the Requirements for a Multi-Allele Vaccine against Malaria. PLoS One. 2012; 7(12):e51023.
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  5. Reiling L, Richards JS, Fowkes FJ, Wilson DW, Chokejindachai W, Barry AE, Tham WH, Stubbs J, Langer C, Donelson J, Michon P, Tavul L, Crabb BS, Siba PM, Cowman AF, Mueller I, Beeson JG. The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria. PLoS One. 2012; 7(9):e45253.
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  6. Cowman AF, Berry D, Baum J. The cellular and molecular basis for malaria parasite invasion of the human red blood cell. J Cell Biol. 2012 Sep 17; 198(6):961-71.
    View in: PubMed
  7. Volz JC, Cowman AF. Unveiling malaria's "cloak of invisibility": The role of PfSET10 in the genetic control of P. falciparum virulence. Virulence. 2012 Aug 15; 3(5):449-51.
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  8. Chan JA, Howell KB, Reiling L, Ataide R, Mackintosh CL, Fowkes FJ, Petter M, Chesson JM, Langer C, Warimwe GM, Duffy MF, Rogerson SJ, Bull PC, Cowman AF, Marsh K, Beeson JG. Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity. J Clin Invest. 2012 Sep 4; 122(9):3227-38.
    View in: PubMed
  9. Taechalertpaisarn T, Crosnier C, Bartholdson SJ, Hodder AN, Thompson J, Bustamante LY, Wilson DW, Sanders PR, Wright GJ, Rayner JC, Cowman AF, Gilson PR, Crabb BS. Biochemical and functional analysis of two Plasmodium falciparum blood-stage 6-cys proteins: P12 and P41. PLoS One. 2012; 7(7):e41937.
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  10. Hodder AN, Czabotar PE, Uboldi AD, Clarke OB, Lin CS, Healer J, Smith BJ, Cowman AF. Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum. J Biol Chem. 2012 Sep 21; 287(39):32922-39.
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  11. Ehlgen F, Pham JS, de Koning-Ward T, Cowman AF, Ralph SA. Investigation of the Plasmodium falciparum food vacuole through inducible expression of the chloroquine resistance transporter (PfCRT). PLoS One. 2012; 7(6):e38781.
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  12. Hoeijmakers WA, Flueck C, Françoijs KJ, Smits AH, Wetzel J, Volz JC, Cowman AF, Voss T, Stunnenberg HG, Bártfai R. Plasmodium falciparum centromeres display a unique epigenetic makeup and cluster prior to and during schizogony. Cell Microbiol. 2012 Sep; 14(9):1391-401.
    View in: PubMed
  13. Tetteh-Quarcoo PB, Schmidt CQ, Tham WH, Hauhart R, Mertens HD, Rowe A, Atkinson JP, Cowman AF, Rowe JA, Barlow PN. Lack of evidence from studies of soluble protein fragments that Knops blood group polymorphisms in complement receptor-type 1 are driven by malaria. PLoS One. 2012; 7(4):e34820.
    View in: PubMed
  14. Angrisano F, Riglar DT, Sturm A, Volz JC, Delves MJ, Zuccala ES, Turnbull L, Dekiwadia C, Olshina MA, Marapana DS, Wong W, Mollard V, Bradin CH, Tonkin CJ, Gunning PW, Ralph SA, Whitchurch CB, Sinden RE, Cowman AF, McFadden GI, Baum J. Spatial localisation of actin filaments across developmental stages of the malaria parasite. PLoS One. 2012; 7(2):e32188.
    View in: PubMed
  15. Volz JC, Bártfai R, Petter M, Langer C, Josling GA, Tsuboi T, Schwach F, Baum J, Rayner JC, Stunnenberg HG, Duffy MF, Cowman AF. PfSET10, a Plasmodium falciparum methyltransferase, maintains the active var gene in a poised state during parasite division. Cell Host Microbe. 2012 Jan 19; 11(1):7-18.
    View in: PubMed
  16. Bullen HE, Charnaud SC, Kalanon M, Riglar DT, Dekiwadia C, Kangwanrangsan N, Torii M, Tsuboi T, Baum J, Ralph SA, Cowman AF, de Koning-Ward TF, Crabb BS, Gilson PR. Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX). J Biol Chem. 2012 Mar 9; 287(11):7871-84.
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  17. Sakamoto H, Takeo S, Maier AG, Sattabongkot J, Cowman AF, Tsuboi T. Antibodies against a Plasmodium falciparum antigen PfMSPDBL1 inhibit merozoite invasion into human erythrocytes. Vaccine. 2012 Mar 2; 30(11):1972-80.
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  18. Tham WH, Healer J, Cowman AF. Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum. Trends Parasitol. 2012 Jan; 28(1):23-30.
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  19. Nebl T, Prieto JH, Kapp E, Smith BJ, Williams MJ, Yates JR, Cowman AF, Tonkin CJ. Quantitative in vivo analyses reveal calcium-dependent phosphorylation sites and identifies a novel component of the Toxoplasma invasion motor complex. PLoS Pathog. 2011 Sep; 7(9):e1002222.
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  20. Arumugam TU, Takeo S, Yamasaki T, Thonkukiatkul A, Miura K, Otsuki H, Zhou H, Long CA, Sattabongkot J, Thompson J, Wilson DW, Beeson JG, Healer J, Crabb BS, Cowman AF, Torii M, Tsuboi T. Discovery of GAMA, a Plasmodium falciparum merozoite micronemal protein, as a novel blood-stage vaccine candidate antigen. Infect Immun. 2011 Nov; 79(11):4523-32.
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  21. Chen L, Lopaticki S, Riglar DT, Dekiwadia C, Uboldi AD, Tham WH, O'Neill MT, Richard D, Baum J, Ralph SA, Cowman AF. An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum. PLoS Pathog. 2011 Sep; 7(9):e1002199.
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  22. Baum J, Cowman AF. Biochemistry. Revealing a parasite's invasive trick. Science. 2011 Jul 22; 333(6041):410-1.
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  23. Mikolajczak SA, Sacci JB, De La Vega P, Camargo N, VanBuskirk K, Krzych U, Cao J, Jacobs-Lorena M, Cowman AF, Kappe SH. Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites. Cell Microbiol. 2011 Aug; 13(8):1250-60.
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  24. Tham WH, Schmidt CQ, Hauhart RE, Guariento M, Tetteh-Quarcoo PB, Lopaticki S, Atkinson JP, Barlow PN, Cowman AF. Plasmodium falciparum uses a key functional site in complement receptor type-1 for invasion of human erythrocytes. Blood. 2011 Aug 18; 118(7):1923-33.
    View in: PubMed
  25. Triglia T, Chen L, Lopaticki S, Dekiwadia C, Riglar DT, Hodder AN, Ralph SA, Baum J, Cowman AF. Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains. PLoS Pathog. 2011 Jun; 7(6):e1002075.
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  26. Petter M, Lee CC, Byrne TJ, Boysen KE, Volz J, Ralph SA, Cowman AF, Brown GV, Duffy MF. Expression of P. falciparum var genes involves exchange of the histone variant H2A.Z at the promoter. PLoS Pathog. 2011 Feb; 7(2):e1001292.
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  27. Richard D, Bartfai R, Volz J, Ralph SA, Muller S, Stunnenberg HG, Cowman AF. A genome-wide chromatin-associated nuclear peroxiredoxin from the malaria parasite Plasmodium falciparum. J Biol Chem. 2011 Apr 1; 286(13):11746-55.
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  28. Cowman AF, Tonkin CJ. Microbiology. A tail of division. Science. 2011 Jan 28; 331(6016):409-10.
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  29. Riglar DT, Richard D, Wilson DW, Boyle MJ, Dekiwadia C, Turnbull L, Angrisano F, Marapana DS, Rogers KL, Whitchurch CB, Beeson JG, Cowman AF, Ralph SA, Baum J. Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte. Cell Host Microbe. 2011 Jan 20; 9(1):9-20.
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  30. Lopaticki S, Maier AG, Thompson J, Wilson DW, Tham WH, Triglia T, Gout A, Speed TP, Beeson JG, Healer J, Cowman AF. Reticulocyte and erythrocyte binding-like proteins function cooperatively in invasion of human erythrocytes by malaria parasites. Infect Immun. 2011 Mar; 79(3):1107-17.
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  31. Reiling L, Richards JS, Fowkes FJ, Barry AE, Triglia T, Chokejindachai W, Michon P, Tavul L, Siba PM, Cowman AF, Mueller I, Beeson JG. Evidence that the erythrocyte invasion ligand PfRh2 is a target of protective immunity against Plasmodium falciparum malaria. J Immunol. 2010 Nov 15; 185(10):6157-67.
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  32. Richards JS, Stanisic DI, Fowkes FJ, Tavul L, Dabod E, Thompson JK, Kumar S, Chitnis CE, Narum DL, Michon P, Siba PM, Cowman AF, Mueller I, Beeson JG. Association between naturally acquired antibodies to erythrocyte-binding antigens of Plasmodium falciparum and protection from malaria and high-density parasitemia. Clin Infect Dis. 2010 Oct 15; 51(8):e50-60.
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  33. Külzer S, Rug M, Brinkmann K, Cannon P, Cowman A, Lingelbach K, Blatch GL, Maier AG, Przyborski JM. Parasite-encoded Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum-infected erythrocyte. Cell Microbiol. 2010 Oct; 12(10):1398-420.
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  34. Tham WH, Wilson DW, Lopaticki S, Schmidt CQ, Tetteh-Quarcoo PB, Barlow PN, Richard D, Corbin JE, Beeson JG, Cowman AF. Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand. Proc Natl Acad Sci U S A. 2010 Oct 5; 107(40):17327-32.
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  35. O'Neill MT, Phuong T, Healer J, Richard D, Cowman AF. Gene deletion from Plasmodium falciparum using FLP and Cre recombinases: implications for applied site-specific recombination. Int J Parasitol. 2011 Jan; 41(1):117-23.
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  36. Goldberg DE, Cowman AF. Moving in and renovating: exporting proteins from Plasmodium into host erythrocytes. Nat Rev Microbiol. 2010 Sep; 8(9):617-21.
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  37. Loukas A, Spithill T, Cowman A. Editorial--ICOPA down under. Int J Parasitol. 2010 Aug 15; 40(10):1107.
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  38. Goldberg DE, Janse CJ, Cowman AF, Waters AP. Has the time come for us to complement our malaria parasites? Trends Parasitol. 2011 Jan; 27(1):1-2.
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  39. Thanh NV, Toan TQ, Cowman AF, Casey GJ, Phuc BQ, Tien NT, Hung NM, Biggs BA. Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009. Malar J. 2010; 9:181.
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  40. Leykauf K, Treeck M, Gilson PR, Nebl T, Braulke T, Cowman AF, Gilberger TW, Crabb BS. Protein kinase a dependent phosphorylation of apical membrane antigen 1 plays an important role in erythrocyte invasion by the malaria parasite. PLoS Pathog. 2010; 6(6):e1000941.
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  41. Kappe SH, Vaughan AM, Boddey JA, Cowman AF. That was then but this is now: malaria research in the time of an eradication agenda. Science. 2010 May 14; 328(5980):862-6.
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  42. Mackellar DC, O'Neill MT, Aly AS, Sacci JB, Cowman AF, Kappe SH. Plasmodium falciparum PF10_0164 (ETRAMP10.3) is an essential parasitophorous vacuole and exported protein in blood stages. Eukaryot Cell. 2010 May; 9(5):784-94.
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  43. Richard D, MacRaild CA, Riglar DT, Chan JA, Foley M, Baum J, Ralph SA, Norton RS, Cowman AF. Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites. J Biol Chem. 2010 May 7; 285(19):14815-22.
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  44. Boddey JA, Hodder AN, Günther S, Gilson PR, Patsiouras H, Kapp EA, Pearce JA, de Koning-Ward TF, Simpson RJ, Crabb BS, Cowman AF. An aspartyl protease directs malaria effector proteins to the host cell. Nature. 2010 Feb 4; 463(7281):627-31.
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  45. Volz J, Carvalho TG, Ralph SA, Gilson P, Thompson J, Tonkin CJ, Langer C, Crabb BS, Cowman AF. Potential epigenetic regulatory proteins localise to distinct nuclear sub-compartments in Plasmodium falciparum. Int J Parasitol. 2010 Jan; 40(1):109-21.
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  46. Rosenberg E, Ben-Shmuel A, Shalev O, Sinay R, Cowman A, Pollack Y. Differential, positional-dependent transcriptional response of antigenic variation (var) genes to biological stress in Plasmodium falciparum. PLoS One. 2009; 4(9):e6991.
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  47. Flueck C, Bartfai R, Volz J, Niederwieser I, Salcedo-Amaya AM, Alako BT, Ehlgen F, Ralph SA, Cowman AF, Bozdech Z, Stunnenberg HG, Voss TS. Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors. PLoS Pathog. 2009 Sep; 5(9):e1000569.
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  48. VanBuskirk KM, O'Neill MT, De La Vega P, Maier AG, Krzych U, Williams J, Dowler MG, Sacci JB, Kangwanrangsan N, Tsuboi T, Kneteman NM, Heppner DG, Murdock BA, Mikolajczak SA, Aly AS, Cowman AF, Kappe SH. Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design. Proc Natl Acad Sci U S A. 2009 Aug 4; 106(31):13004-9.
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  49. Triglia T, Tham WH, Hodder A, Cowman AF. Reticulocyte binding protein homologues are key adhesins during erythrocyte invasion by Plasmodium falciparum. Cell Microbiol. 2009 Nov; 11(11):1671-87.
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  50. Bullen HE, Tonkin CJ, O'Donnell RA, Tham WH, Papenfuss AT, Gould S, Cowman AF, Crabb BS, Gilson PR. A novel family of Apicomplexan glideosome-associated proteins with an inner membrane-anchoring role. J Biol Chem. 2009 Sep 11; 284(37):25353-63.
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  51. de Koning-Ward TF, Gilson PR, Boddey JA, Rug M, Smith BJ, Papenfuss AT, Sanders PR, Lundie RJ, Maier AG, Cowman AF, Crabb BS. A newly discovered protein export machine in malaria parasites. Nature. 2009 Jun 18; 459(7249):945-9.
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  52. Maier AG, Cooke BM, Cowman AF, Tilley L. Malaria parasite proteins that remodel the host erythrocyte. Nat Rev Microbiol. 2009 May; 7(5):341-54.
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  53. DeSimone TM, Jennings CV, Bei AK, Comeaux C, Coleman BI, Refour P, Triglia T, Stubbs J, Cowman AF, Duraisingh MT. Cooperativity between Plasmodium falciparum adhesive proteins for invasion into erythrocytes. Mol Microbiol. 2009 May; 72(3):578-89.
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  54. Baum J, Papenfuss AT, Mair GR, Janse CJ, Vlachou D, Waters AP, Cowman AF, Crabb BS, de Koning-Ward TF. Molecular genetics and comparative genomics reveal RNAi is not functional in malaria parasites. Nucleic Acids Res. 2009 Jun; 37(11):3788-98.
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  55. Tonkin CJ, Carret CK, Duraisingh MT, Voss TS, Ralph SA, Hommel M, Duffy MF, Silva LM, Scherf A, Ivens A, Speed TP, Beeson JG, Cowman AF. Sir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparum. PLoS Biol. 2009 Apr 14; 7(4):e84.
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  56. Tham WH, Wilson DW, Reiling L, Chen L, Beeson JG, Cowman AF. Antibodies to reticulocyte binding protein-like homologue 4 inhibit invasion of Plasmodium falciparum into human erythrocytes. Infect Immun. 2009 Jun; 77(6):2427-35.
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  57. Richard D, Kats LM, Langer C, Black CG, Mitri K, Boddey JA, Cowman AF, Coppel RL. Identification of rhoptry trafficking determinants and evidence for a novel sorting mechanism in the malaria parasite Plasmodium falciparum. PLoS Pathog. 2009 Mar; 5(3):e1000328.
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  58. Maier AG, Baum J, Smith B, Conway DJ, Cowman AF. Polymorphisms in erythrocyte binding antigens 140 and 181 affect function and binding but not receptor specificity in Plasmodium falciparum. Infect Immun. 2009 Apr; 77(4):1689-99.
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  59. Boddey JA, Moritz RL, Simpson RJ, Cowman AF. Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte. Traffic. 2009 Mar; 10(3):285-99.
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  60. Vaughan AM, O'Neill MT, Tarun AS, Camargo N, Phuong TM, Aly AS, Cowman AF, Kappe SH. Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cell Microbiol. 2009 Mar; 11(3):506-20.
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  61. Hodder AN, Maier AG, Rug M, Brown M, Hommel M, Pantic I, Puig-de-Morales-Marinkovic M, Smith B, Triglia T, Beeson J, Cowman AF. Analysis of structure and function of the giant protein Pf332 in Plasmodium falciparum. Mol Microbiol. 2009 Jan; 71(1):48-65.
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  62. Phuc BQ, Caruana SR, Cowman AF, Biggs BA, Thanh NV, Tien NT, Thuan le K. Prevalence of polymorphisms in DHFR, DHPS, PFMDR1 and PFCRT genes of Plasmodium falciparum isolates in Quang Tri Province, Vietnam. Southeast Asian J Trop Med Public Health. 2008 Nov; 39(6):959-62.
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  63. Baum J, Chen L, Healer J, Lopaticki S, Boyle M, Triglia T, Ehlgen F, Ralph SA, Beeson JG, Cowman AF. Reticulocyte-binding protein homologue 5 - an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum. Int J Parasitol. 2009 Feb; 39(3):371-80.
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  64. Cooke BM, Crabb BS, Cowman A. Spotlight on malaria: MAM2008. Trends Parasitol. 2008 Dec; 24(12):531.
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  65. Pain A, Böhme U, Berry AE, Mungall K, Finn RD, Jackson AP, Mourier T, Mistry J, Pasini EM, Aslett MA, Balasubrammaniam S, Borgwardt K, Brooks K, Carret C, Carver TJ, Cherevach I, Chillingworth T, Clark TG, Galinski MR, Hall N, Harper D, Harris D, Hauser H, Ivens A, Janssen CS, Keane T, Larke N, Lapp S, Marti M, Moule S, Meyer IM, Ormond D, Peters N, Sanders M, Sanders S, Sargeant TJ, Simmonds M, Smith F, Squares R, Thurston S, Tivey AR, Walker D, White B, Zuiderwijk E, Churcher C, Quail MA, Cowman AF, Turner CM, Rajandream MA, Kocken CH, Thomas AW, Newbold CI, Barrell BG, Berriman M. The genome of the simian and human malaria parasite Plasmodium knowlesi. Nature. 2008 Oct 9; 455(7214):799-803.
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  66. Maier AG, Rug M, O'Neill MT, Brown M, Chakravorty S, Szestak T, Chesson J, Wu Y, Hughes K, Coppel RL, Newbold C, Beeson JG, Craig A, Crabb BS, Cowman AF. Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes. Cell. 2008 Jul 11; 134(1):48-61.
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  67. Struck NS, Herrmann S, Langer C, Krueger A, Foth BJ, Engelberg K, Cabrera AL, Haase S, Treeck M, Marti M, Cowman AF, Spielmann T, Gilberger TW. Plasmodium falciparum possesses two GRASP proteins that are differentially targeted to the Golgi complex via a higher- and lower-eukaryote-like mechanism. J Cell Sci. 2008 Jul 1; 121(Pt 13):2123-9.
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  68. Spycher C, Rug M, Pachlatko E, Hanssen E, Ferguson D, Cowman AF, Tilley L, Beck HP. The Maurer's cleft protein MAHRP1 is essential for trafficking of PfEMP1 to the surface of Plasmodium falciparum-infected erythrocytes. Mol Microbiol. 2008 Jun; 68(5):1300-14.
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  69. Gould SB, Tham WH, Cowman AF, McFadden GI, Waller RF. Alveolins, a new family of cortical proteins that define the protist infrakingdom Alveolata. Mol Biol Evol. 2008 Jun; 25(6):1219-30.
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  70. Tonkin CJ, Foth BJ, Ralph SA, Struck N, Cowman AF, McFadden GI. Evolution of malaria parasite plastid targeting sequences. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4781-5.
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  71. Baum J, Tonkin CJ, Paul AS, Rug M, Smith BJ, Gould SB, Richard D, Pollard TD, Cowman AF. A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion. Cell Host Microbe. 2008 Mar 13; 3(3):188-98.
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  72. Struck NS, Herrmann S, Schmuck-Barkmann I, de Souza Dias S, Haase S, Cabrera AL, Treeck M, Bruns C, Langer C, Cowman AF, Marti M, Spielmann T, Gilberger TW. Spatial dissection of the cis- and trans-Golgi compartments in the malaria parasite Plasmodium falciparum. Mol Microbiol. 2008 Mar; 67(6):1320-30.
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  73. Haase S, Cabrera A, Langer C, Treeck M, Struck N, Herrmann S, Jansen PW, Bruchhaus I, Bachmann A, Dias S, Cowman AF, Stunnenberg HG, Spielmann T, Gilberger TW. Characterization of a conserved rhoptry-associated leucine zipper-like protein in the malaria parasite Plasmodium falciparum. Infect Immun. 2008 Mar; 76(3):879-87.
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  74. Persson KE, McCallum FJ, Reiling L, Lister NA, Stubbs J, Cowman AF, Marsh K, Beeson JG. Variation in use of erythrocyte invasion pathways by Plasmodium falciparum mediates evasion of human inhibitory antibodies. J Clin Invest. 2008 Jan; 118(1):342-51.
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  75. Voss TS, Tonkin CJ, Marty AJ, Thompson JK, Healer J, Crabb BS, Cowman AF. Alterations in local chromatin environment are involved in silencing and activation of subtelomeric var genes in Plasmodium falciparum. Mol Microbiol. 2007 Oct; 66(1):139-50.
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  76. D'Ombrain MC, Voss TS, Maier AG, Pearce JA, Hansen DS, Cowman AF, Schofield L. Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma. Cell Host Microbe. 2007 Aug 16; 2(2):130-8.
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  77. Dasaradhi PV, Korde R, Thompson JK, Tanwar C, Nag TC, Chauhan VS, Cowman AF, Mohmmed A, Malhotra P. Food vacuole targeting and trafficking of falcipain-2, an important cysteine protease of human malaria parasite Plasmodium falciparum. Mol Biochem Parasitol. 2007 Nov; 156(1):12-23.
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  78. Elliott SR, Spurck TP, Dodin JM, Maier AG, Voss TS, Yosaatmadja F, Payne PD, McFadden GI, Cowman AF, Rogerson SJ, Schofield L, Brown GV. Inhibition of dendritic cell maturation by malaria is dose dependent and does not require Plasmodium falciparum erythrocyte membrane protein 1. Infect Immun. 2007 Jul; 75(7):3621-32.
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  79. Tilley L, McFadden G, Cowman A, Klonis N. Illuminating Plasmodium falciparum-infected red blood cells. Trends Parasitol. 2007 Jun; 23(6):268-77.
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  80. Adisa A, Frankland S, Rug M, Jackson K, Maier AG, Walsh P, Lithgow T, Klonis N, Gilson PR, Cowman AF, Tilley L. Re-assessing the locations of components of the classical vesicle-mediated trafficking machinery in transfected Plasmodium falciparum. Int J Parasitol. 2007 Aug; 37(10):1127-41.
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  81. Maier AG, Rug M, O'Neill MT, Beeson JG, Marti M, Reeder J, Cowman AF. Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface. Blood. 2007 Feb 1; 109(3):1289-97.
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  82. Cowman AF, Kappe SH. Microbiology. Malaria's stealth shuttle. Science. 2006 Sep 1; 313(5791):1245-6.
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  83. Marty AJ, Thompson JK, Duffy MF, Voss TS, Cowman AF, Crabb BS. Evidence that Plasmodium falciparum chromosome end clusters are cross-linked by protein and are the sites of both virulence gene silencing and activation. Mol Microbiol. 2006 Oct; 62(1):72-83.
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  84. Treeck M, Struck NS, Haase S, Langer C, Herrmann S, Healer J, Cowman AF, Gilberger TW. A conserved region in the EBL proteins is implicated in microneme targeting of the malaria parasite Plasmodium falciparum. J Biol Chem. 2006 Oct 20; 281(42):31995-2003.
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  85. Baum J, Papenfuss AT, Baum B, Speed TP, Cowman AF. Regulation of apicomplexan actin-based motility. Nat Rev Microbiol. 2006 Aug; 4(8):621-8.
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  86. Maier AG, Braks JA, Waters AP, Cowman AF. Negative selection using yeast cytosine deaminase/uracil phosphoribosyl transferase in Plasmodium falciparum for targeted gene deletion by double crossover recombination. Mol Biochem Parasitol. 2006 Nov; 150(1):118-21.
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  87. Tonkin CJ, Pearce JA, McFadden GI, Cowman AF. Protein targeting to destinations of the secretory pathway in the malaria parasite Plasmodium falciparum. Curr Opin Microbiol. 2006 Aug; 9(4):381-7.
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  88. Spycher C, Rug M, Klonis N, Ferguson DJ, Cowman AF, Beck HP, Tilley L. Genesis of and trafficking to the Maurer's clefts of Plasmodium falciparum-infected erythrocytes. Mol Cell Biol. 2006 Jun; 26(11):4074-85.
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  89. Frankland S, Adisa A, Horrocks P, Taraschi TF, Schneider T, Elliott SR, Rogerson SJ, Knuepfer E, Cowman AF, Newbold CI, Tilley L. Delivery of the malaria virulence protein PfEMP1 to the erythrocyte surface requires cholesterol-rich domains. Eukaryot Cell. 2006 May; 5(5):849-60.
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  90. Duffy MF, Maier AG, Byrne TJ, Marty AJ, Elliott SR, O'Neill MT, Payne PD, Rogerson SJ, Cowman AF, Crabb BS, Brown GV. VAR2CSA is the principal ligand for chondroitin sulfate A in two allogeneic isolates of Plasmodium falciparum. Mol Biochem Parasitol. 2006 Aug; 148(2):117-24.
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  91. Rug M, Prescott SW, Fernandez KM, Cooke BM, Cowman AF. The role of KAHRP domains in knob formation and cytoadherence of P falciparum-infected human erythrocytes. Blood. 2006 Jul 1; 108(1):370-8.
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  92. Cowman AF, Crabb BS. Invasion of red blood cells by malaria parasites. Cell. 2006 Feb 24; 124(4):755-66.
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  93. Sargeant TJ, Marti M, Caler E, Carlton JM, Simpson K, Speed TP, Cowman AF. Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites. Genome Biol. 2006; 7(2):R12.
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  94. Voss TS, Healer J, Marty AJ, Duffy MF, Thompson JK, Beeson JG, Reeder JC, Crabb BS, Cowman AF. A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria. Nature. 2006 Feb 23; 439(7079):1004-8.
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  95. Baum J, Maier AG, Good RT, Simpson KM, Cowman AF. Invasion by P. falciparum merozoites suggests a hierarchy of molecular interactions. PLoS Pathog. 2005 Dec; 1(4):e37.
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  96. Struck NS, de Souza Dias S, Langer C, Marti M, Pearce JA, Cowman AF, Gilberger TW. Re-defining the Golgi complex in Plasmodium falciparum using the novel Golgi marker PfGRASP. J Cell Sci. 2005 Dec 1; 118(Pt 23):5603-13.
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  97. Baum J, Richard D, Healer J, Rug M, Krnajski Z, Gilberger TW, Green JL, Holder AA, Cowman AF. A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites. J Biol Chem. 2006 Feb 24; 281(8):5197-208.
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  98. Marti M, Baum J, Rug M, Tilley L, Cowman AF. Signal-mediated export of proteins from the malaria parasite to the host erythrocyte. J Cell Biol. 2005 Nov 21; 171(4):587-92.
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  99. Knuepfer E, Rug M, Klonis N, Tilley L, Cowman AF. Trafficking determinants for PfEMP3 export and assembly under the Plasmodium falciparum-infected red blood cell membrane. Mol Microbiol. 2005 Nov; 58(4):1039-53.
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  100. Cooke BM, Mohandas N, Cowman AF, Coppel RL. Cellular adhesive phenomena in apicomplexan parasites of red blood cells. Vet Parasitol. 2005 Sep 30; 132(3-4):273-95.
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  101. Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, Duraisingh MT, Maier AG, Winzeler EA, Cowman AF. Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science. 2005 Aug 26; 309(5739):1384-7.
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  102. Knuepfer E, Rug M, Cowman AF. Function of the plasmodium export element can be blocked by green fluorescent protein. Mol Biochem Parasitol. 2005 Aug; 142(2):258-62.
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  103. van Dooren GG, Marti M, Tonkin CJ, Stimmler LM, Cowman AF, McFadden GI. Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum. Mol Microbiol. 2005 Jul; 57(2):405-19.
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  104. Cowman AF, Crabb BS. Revealing the molecular determinants of gender in malaria parasites. Cell. 2005 Jun 3; 121(5):659-60.
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  105. Duraisingh MT, Cowman AF. Contribution of the pfmdr1 gene to antimalarial drug-resistance. Acta Trop. 2005 Jun; 94(3):181-90.
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  106. Fu J, Sáenz FE, Reed MB, Balu B, Singh N, Blair PL, Cowman AF, Adams JH. Targeted disruption of maebl in Plasmodium falciparum. Mol Biochem Parasitol. 2005 May; 141(1):113-7.
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  107. Simpson KM, Baum J, Good RT, Winzeler EA, Cowman AF, Speed TP. A comparison of match-only algorithms for the analysis of Plasmodium falciparum oligonucleotide arrays. Int J Parasitol. 2005 Apr 30; 35(5):523-31.
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  108. Duraisingh MT, Voss TS, Marty AJ, Duffy MF, Good RT, Thompson JK, Freitas-Junior LH, Scherf A, Crabb BS, Cowman AF. Heterochromatin silencing and locus repositioning linked to regulation of virulence genes in Plasmodium falciparum. Cell. 2005 Apr 8; 121(1):13-24.
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  109. Healer J, Triglia T, Hodder AN, Gemmill AW, Cowman AF. Functional analysis of Plasmodium falciparum apical membrane antigen 1 utilizing interspecies domains. Infect Immun. 2005 Apr; 73(4):2444-51.
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  110. Knuepfer E, Rug M, Klonis N, Tilley L, Cowman AF. Trafficking of the major virulence factor to the surface of transfected P. falciparum-infected erythrocytes. Blood. 2005 May 15; 105(10):4078-87.
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  111. Syafruddin D, Asih PB, Casey GJ, Maguire J, Baird JK, Nagesha HS, Cowman AF, Reeder JC. Molecular epidemiology of Plasmodium falciparum resistance to antimalarial drugs in Indonesia. Am J Trop Med Hyg. 2005 Feb; 72(2):174-81.
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  112. Pearce JA, Mills K, Triglia T, Cowman AF, Anders RF. Characterisation of two novel proteins from the asexual stage of Plasmodium falciparum, H101 and H103. Mol Biochem Parasitol. 2005 Feb; 139(2):141-51.
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  113. Triglia T, Duraisingh MT, Good RT, Cowman AF. Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum. Mol Microbiol. 2005 Jan; 55(1):162-74.
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  114. Marti M, Good RT, Rug M, Knuepfer E, Cowman AF. Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science. 2004 Dec 10; 306(5703):1930-3.
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  115. Soldati D, Foth BJ, Cowman AF. Molecular and functional aspects of parasite invasion. Trends Parasitol. 2004 Dec; 20(12):567-74.
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  116. Wiek S, Cowman AF, Lingelbach K. Double cross-over gene replacement within the sec 7 domain of a GDP-GTP exchange factor from Plasmodium falciparum allows the generation of a transgenic brefeldin A-resistant parasite line. Mol Biochem Parasitol. 2004 Nov; 138(1):51-5.
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  117. Rug M, Wickham ME, Foley M, Cowman AF, Tilley L. Correct promoter control is needed for trafficking of the ring-infected erythrocyte surface antigen to the host cytosol in transfected malaria parasites. Infect Immun. 2004 Oct; 72(10):6095-105.
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  118. Kasekarn W, Sirawaraporn R, Chahomchuen T, Cowman AF, Sirawaraporn W. Molecular characterization of bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium falciparum. Mol Biochem Parasitol. 2004 Sep; 137(1):43-53.
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  119. Tonkin CJ, van Dooren GG, Spurck TP, Struck NS, Good RT, Handman E, Cowman AF, McFadden GI. Localization of organellar proteins in Plasmodium falciparum using a novel set of transfection vectors and a new immunofluorescence fixation method. Mol Biochem Parasitol. 2004 Sep; 137(1):13-21.
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  120. Healer J, Murphy V, Hodder AN, Masciantonio R, Gemmill AW, Anders RF, Cowman AF, Batchelor A. Allelic polymorphisms in apical membrane antigen-1 are responsible for evasion of antibody-mediated inhibition in Plasmodium falciparum. Mol Microbiol. 2004 Apr; 52(1):159-68.
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  121. Pearce JA, Triglia T, Hodder AN, Jackson DC, Cowman AF, Anders RF. Plasmodium falciparum merozoite surface protein 6 is a dimorphic antigen. Infect Immun. 2004 Apr; 72(4):2321-8.
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  122. Casey GJ, Ginny M, Uranoli M, Mueller I, Reeder JC, Genton B, Cowman AF. Molecular analysis of Plasmodium falciparum from drug treatment failure patients in Papua New Guinea. Am J Trop Med Hyg. 2004 Mar; 70(3):251-5.
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  123. Chow C, Gauci CG, Cowman AF, Lightowlers MW. Echinococcus granulosus: oncosphere-specific transcription of genes encoding a host-protective antigen. Exp Parasitol. 2004 Mar-Apr; 106(3-4):183-6.
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  124. Crabb BS, Rug M, Gilberger TW, Thompson JK, Triglia T, Maier AG, Cowman AF. Transfection of the human malaria parasite Plasmodium falciparum. Methods Mol Biol. 2004; 270:263-76.
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  125. Cowman AF, Crabb BS. Functional genomics: identifying drug targets for parasitic diseases. Trends Parasitol. 2003 Nov; 19(11):538-43.
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  126. Gilberger TW, Thompson JK, Reed MB, Good RT, Cowman AF. The cytoplasmic domain of the Plasmodium falciparum ligand EBA-175 is essential for invasion but not protein trafficking. J Cell Biol. 2003 Jul 21; 162(2):317-27.
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  127. Wickham ME, Culvenor JG, Cowman AF. Selective inhibition of a two-step egress of malaria parasites from the host erythrocyte. J Biol Chem. 2003 Sep 26; 278(39):37658-63.
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  128. Wickham ME, Thompson JK, Cowman AF. Characterisation of the merozoite surface protein-2 promoter using stable and transient transfection in Plasmodium falciparum. Mol Biochem Parasitol. 2003 Jul; 129(2):147-56.
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  129. Duraisingh MT, Maier AG, Triglia T, Cowman AF. Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways. Proc Natl Acad Sci U S A. 2003 Apr 15; 100(8):4796-801.
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  130. Duraisingh MT, Triglia T, Ralph SA, Rayner JC, Barnwell JW, McFadden GI, Cowman AF. Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes. EMBO J. 2003 Mar 3; 22(5):1047-57.
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  131. Ngo T, Duraisingh M, Reed M, Hipgrave D, Biggs B, Cowman AF. Analysis of pfcrt, pfmdr1, dhfr, and dhps mutations and drug sensitivities in Plasmodium falciparum isolates from patients in Vietnam before and after treatment with artemisinin. Am J Trop Med Hyg. 2003 Mar; 68(3):350-6.
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  132. Foth BJ, Ralph SA, Tonkin CJ, Struck NS, Fraunholz M, Roos DS, Cowman AF, McFadden GI. Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum. Science. 2003 Jan 31; 299(5607):705-8.
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  133. Gilberger TW, Thompson JK, Triglia T, Good RT, Duraisingh MT, Cowman AF. A novel erythrocyte binding antigen-175 paralogue from Plasmodium falciparum defines a new trypsin-resistant receptor on human erythrocytes. J Biol Chem. 2003 Apr 18; 278(16):14480-6.
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  134. Waller RF, Ralph SA, Reed MB, Su V, Douglas JD, Minnikin DE, Cowman AF, Besra GS, McFadden GI. A type II pathway for fatty acid biosynthesis presents drug targets in Plasmodium falciparum. Antimicrob Agents Chemother. 2003 Jan; 47(1):297-301.
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  135. Maier AG, Duraisingh MT, Reeder JC, Patel SS, Kazura JW, Zimmerman PA, Cowman AF. Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations. Nat Med. 2003 Jan; 9(1):87-92.
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  136. Adisa A, Rug M, Klonis N, Foley M, Cowman AF, Tilley L. The signal sequence of exported protein-1 directs the green fluorescent protein to the parasitophorous vacuole of transfected malaria parasites. J Biol Chem. 2003 Feb 21; 278(8):6532-42.
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  137. Cowman AF, Crabb BS. A parasite genome sheds light on an old enemy. Nat Biotechnol. 2002 Nov; 20(11):1098-9.
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  138. Crabb BS, Cowman AF. Plasmodium falciparum virulence determinants unveiled. Genome Biol. 2002 Oct 25; 3(11):REVIEWS1031.
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  139. Cowman AF, Crabb BS. The Plasmodium falciparum genome--a blueprint for erythrocyte invasion. Science. 2002 Oct 4; 298(5591):126-8.
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  140. Healer J, Crawford S, Ralph S, McFadden G, Cowman AF. Independent translocation of two micronemal proteins in developing Plasmodium falciparum merozoites. Infect Immun. 2002 Oct; 70(10):5751-8.
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  141. Miller SK, Good RT, Drew DR, Delorenzi M, Sanders PR, Hodder AN, Speed TP, Cowman AF, de Koning-Ward TF, Crabb BS. A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycle. J Biol Chem. 2002 Dec 6; 277(49):47524-32.
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  142. Baldi DL, Good R, Duraisingh MT, Crabb BS, Cowman AF. Identification and disruption of the gene encoding the third member of the low-molecular-mass rhoptry complex in Plasmodium falciparum. Infect Immun. 2002 Sep; 70(9):5236-45.
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  143. Krnajski Z, Gilberger TW, Walter RD, Cowman AF, Müller S. Thioredoxin reductase is essential for the survival of Plasmodium falciparum erythrocytic stages. J Biol Chem. 2002 Jul 19; 277(29):25970-5.
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  144. Mills KE, Pearce JA, Crabb BS, Cowman AF. Truncation of merozoite surface protein 3 disrupts its trafficking and that of acidic-basic repeat protein to the surface of Plasmodium falciparum merozoites. Mol Microbiol. 2002 Mar; 43(6):1401-11.
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  145. Klonis N, Rug M, Harper I, Wickham M, Cowman A, Tilley L. Fluorescence photobleaching analysis for the study of cellular dynamics. Eur Biophys J. 2002 Mar; 31(1):36-51.
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  146. O'Donnell RA, Freitas-Junior LH, Preiser PR, Williamson DH, Duraisingh M, McElwain TF, Scherf A, Cowman AF, Crabb BS. A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes. EMBO J. 2002 Mar 1; 21(5):1231-9.
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  147. Duffy MF, Brown GV, Basuki W, Krejany EO, Noviyanti R, Cowman AF, Reeder JC. Transcription of multiple var genes by individual, trophozoite-stage Plasmodium falciparum cells expressing a chondroitin sulphate A binding phenotype. Mol Microbiol. 2002 Mar; 43(5):1285-93.
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  148. Glenister FK, Coppel RL, Cowman AF, Mohandas N, Cooke BM. Contribution of parasite proteins to altered mechanical properties of malaria-infected red blood cells. Blood. 2002 Feb 1; 99(3):1060-3.
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  149. Cowman AF, Baldi DL, Duraisingh M, Healer J, Mills KE, O'Donnell RA, Thompson J, Triglia T, Wickham ME, Crabb BS. Functional analysis of Plasmodium falciparum merozoite antigens: implications for erythrocyte invasion and vaccine development. Philos Trans R Soc Lond B Biol Sci. 2002 Jan 29; 357(1417):25-33.
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  150. Duraisingh MT, Triglia T, Cowman AF. Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. Int J Parasitol. 2002 Jan; 32(1):81-9.
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  151. Sibley CH, Hyde JE, Sims PF, Plowe CV, Kublin JG, Mberu EK, Cowman AF, Winstanley PA, Watkins WM, Nzila AM. Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next? Trends Parasitol. 2001 Dec; 17(12):582-8.
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  152. Chow C, Gauci CG, Cowman AF, Lightowlers MW. A gene family expressing a host-protective antigen of Echinococcus granulosus. Mol Biochem Parasitol. 2001 Nov; 118(1):83-8.
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  153. Wickham ME, Rug M, Ralph SA, Klonis N, McFadden GI, Tilley L, Cowman AF. Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes. EMBO J. 2001 Oct 15; 20(20):5636-49.
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  154. Thanh NV, Cowman AF, Hipgrave D, Kim TB, Phuc BQ, Cong LD, Biggs BA. Assessment of susceptibility of Plasmodium falciparum to chloroquine, quinine, mefloquine, sulfadoxine-pyrimethamine and artemisinin in southern Viet Nam. Trans R Soc Trop Med Hyg. 2001 Sep-Oct; 95(5):513-7.
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  155. Triglia T, Thompson JK, Cowman AF. An EBA175 homologue which is transcribed but not translated in erythrocytic stages of Plasmodium falciparum. Mol Biochem Parasitol. 2001 Aug; 116(1):55-63.
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  156. Thompson JK, Triglia T, Reed MB, Cowman AF. A novel ligand from Plasmodium falciparum that binds to a sialic acid-containing receptor on the surface of human erythrocytes. Mol Microbiol. 2001 Jul; 41(1):47-58.
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  157. Cowman AF. Functional analysis of drug resistance in Plasmodium falciparum in the post-genomic era. Int J Parasitol. 2001 Jul; 31(9):871-8.
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  158. O'Donnell RA, de Koning-Ward TF, Burt RA, Bockarie M, Reeder JC, Cowman AF, Crabb BS. Antibodies against merozoite surface protein (MSP)-1(19) are a major component of the invasion-inhibitory response in individuals immune to malaria. J Exp Med. 2001 Jun 18; 193(12):1403-12.
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  159. Taylor HM, Triglia T, Thompson J, Sajid M, Fowler R, Wickham ME, Cowman AF, Holder AA. Plasmodium falciparum homologue of the genes for Plasmodium vivax and Plasmodium yoelii adhesive proteins, which is transcribed but not translated. Infect Immun. 2001 Jun; 69(6):3635-45.
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  160. Noviyanti R, Brown GV, Wickham ME, Duffy MF, Cowman AF, Reeder JC. Multiple var gene transcripts are expressed in Plasmodium falciparum infected erythrocytes selected for adhesion. Mol Biochem Parasitol. 2001 May; 114(2):227-37.
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  161. O'Donnell RA, Preiser PR, Williamson DH, Moore PW, Cowman AF, Crabb BS. An alteration in concatameric structure is associated with efficient segregation of plasmids in transfected Plasmodium falciparum parasites. Nucleic Acids Res. 2001 Feb 1; 29(3):716-24.
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  162. Cowman AF, Duraisingh MT. An old enemy, a new battle plan. Perspective on combating drug-resistant malaria. EMBO Rep. 2001 Feb; 2(2):77-9.
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  163. Triglia T, Thompson J, Caruana SR, Delorenzi M, Speed T, Cowman AF. Identification of proteins from Plasmodium falciparum that are homologous to reticulocyte binding proteins in Plasmodium vivax. Infect Immun. 2001 Feb; 69(2):1084-92.
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  164. Waterkeyn JG, Cowman AF, Cooke BM. Plasmodium falciparum: gelatin enrichment selects for parasites with full-length chromosome 2. implications for cytoadhesion assays. Exp Parasitol. 2001 Feb; 97(2):115-8.
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  165. Nagesha HS, Casey GJ, Susanti AI, Fryauff DJ, Reeder JC, Cowman AF. Mutations in the pfmdr1, dhfr and dhps genes of Plasmodium falciparum are associated with in-vivo drug resistance in West Papua, Indonesia. Trans R Soc Trop Med Hyg. 2001 Jan-Feb; 95(1):43-9.
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  166. Triglia T, Healer J, Caruana SR, Hodder AN, Anders RF, Crabb BS, Cowman AF. Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species. Mol Microbiol. 2000 Nov; 38(4):706-18.
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  167. Cowman AF, Baldi DL, Healer J, Mills KE, O'Donnell RA, Reed MB, Triglia T, Wickham ME, Crabb BS. Functional analysis of proteins involved in Plasmodium falciparum merozoite invasion of red blood cells. FEBS Lett. 2000 Jun 30; 476(1-2):84-8.
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  168. Reed MB, Caruana SR, Batchelor AH, Thompson JK, Crabb BS, Cowman AF. Targeted disruption of an erythrocyte binding antigen in Plasmodium falciparum is associated with a switch toward a sialic acid-independent pathway of invasion. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7509-14.
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  169. Waterkeyn JG, Wickham ME, Davern KM, Cooke BM, Coppel RL, Reeder JC, Culvenor JG, Waller RF, Cowman AF. Targeted mutagenesis of Plasmodium falciparum erythrocyte membrane protein 3 (PfEMP3) disrupts cytoadherence of malaria-infected red blood cells. EMBO J. 2000 Jun 15; 19(12):2813-23.
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  170. Baldi DL, Andrews KT, Waller RF, Roos DS, Howard RF, Crabb BS, Cowman AF. RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparum. EMBO J. 2000 Jun 1; 19(11):2435-43.
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  171. Cooke BM, Cowman AF. Molecular approaches to malaria. Parasitol Today. 2000 May; 16(5):177-8.
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  172. Waller RF, Reed MB, Cowman AF, McFadden GI. Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway. EMBO J. 2000 Apr 17; 19(8):1794-802.
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  173. Trenholme KR, Gardiner DL, Holt DC, Thomas EA, Cowman AF, Kemp DJ. clag9: A cytoadherence gene in Plasmodium falciparum essential for binding of parasitized erythrocytes to CD36. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4029-33.
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  174. Voss TS, Thompson JK, Waterkeyn J, Felger I, Weiss N, Cowman AF, Beck HP. Genomic distribution and functional characterisation of two distinct and conserved Plasmodium falciparum var gene 5' flanking sequences. Mol Biochem Parasitol. 2000 Mar 15; 107(1):103-15.
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  175. Reed MB, Saliba KJ, Caruana SR, Kirk K, Cowman AF. Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum. Nature. 2000 Feb 24; 403(6772):906-9.
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  176. O'Donnell RA, Saul A, Cowman AF, Crabb BS. Functional conservation of the malaria vaccine antigen MSP-119across distantly related Plasmodium species. Nat Med. 2000 Jan; 6(1):91-5.
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  177. Chaiyaroj SC, Buranakiti A, Angkasekwinai P, Looressuwan S, Cowman AF. Analysis of mefloquine resistance and amplification of pfmdr1 in multidrug-resistant Plasmodium falciparum isolates from Thailand. Am J Trop Med Hyg. 1999 Nov; 61(5):780-3.
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  178. Thompson JK, Caruana SR, Cowman AF. YAC contigs and restriction maps of chromosomes 4 and 5 from the cloned line 3D7 of Plasmodium falciparum. Mol Biochem Parasitol. 1999 Jul 30; 102(1):197-204.
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  179. Triglia T, Cowman AF. Plasmodium falciparum: a homologue of p-aminobenzoic acid synthetase. Exp Parasitol. 1999 Jun; 92(2):154-8.
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  180. Waterkeyn JG, Crabb BS, Cowman AF. Transfection of the human malaria parasite Plasmodium falciparum. Int J Parasitol. 1999 Jun; 29(6):945-55.
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  181. Reeder JC, Cowman AF, Davern KM, Beeson JG, Thompson JK, Rogerson SJ, Brown GV. The adhesion of Plasmodium falciparum-infected erythrocytes to chondroitin sulfate A is mediated by P. falciparum erythrocyte membrane protein 1. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):5198-202.
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  182. Waller RF, Keeling PJ, Donald RG, Striepen B, Handman E, Lang-Unnasch N, Cowman AF, Besra GS, Roos DS, McFadden GI. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12352-7.
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  183. Triglia T, Wang P, Sims PF, Hyde JE, Cowman AF. Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria. EMBO J. 1998 Jul 15; 17(14):3807-15.
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  184. Humberstone AJ, Cowman AF, Horton J, Charman WN. Effect of altered serum lipid concentrations on the IC50 of halofantrine against Plasmodium falciparum. J Pharm Sci. 1998 Feb; 87(2):256-8.
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  185. Waterkeyn JG, Gauci C, Cowman AF, Lightowlers MW. Codon usage in Taenia species. Exp Parasitol. 1998 Jan; 88(1):76-8.
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  186. Thompson JK, Cowman AF. A YAC contig and high resolution restriction map of chromosome 3 from Plasmodium falciparum. Mol Biochem Parasitol. 1997 Dec 15; 90(2):537-42.
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  187. Triglia T, Menting JG, Wilson C, Cowman AF. Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum. Proc Natl Acad Sci U S A. 1997 Dec 9; 94(25):13944-9.
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  188. Crabb BS, Triglia T, Waterkeyn JG, Cowman AF. Stable transgene expression in Plasmodium falciparum. Mol Biochem Parasitol. 1997 Dec 1; 90(1):131-44.
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  189. Menting JG, Tilley L, Deady LW, Ng K, Simpson RJ, Cowman AF, Foley M. The antimalarial drug, chloroquine, interacts with lactate dehydrogenase from Plasmodium falciparum. Mol Biochem Parasitol. 1997 Sep; 88(1-2):215-24.
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  190. Thompson JK, Rubio JP, Caruana S, Brockman A, Wickham ME, Cowman AF. The chromosomal organization of the Plasmodium falciparum var gene family is conserved. Mol Biochem Parasitol. 1997 Jul; 87(1):49-60.
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  191. Waterkeyn JG, Cowman AF, Lightowlers MW. Taenia ovis: copy number of genes encoding host-protective antigens determined by competitive PCR. Exp Parasitol. 1997 May; 86(1):84-8.
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  192. Waterkeyn J, Gauci C, Cowman A, Lightowlers M. Sequence analysis of a gene family encoding Taenia ovis vaccine antigens expressed during embryogenesis of eggs. Mol Biochem Parasitol. 1997 May; 86(1):75-84.
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  193. Crabb BS, Cooke BM, Reeder JC, Waller RF, Caruana SR, Davern KM, Wickham ME, Brown GV, Coppel RL, Cowman AF. Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear stress. Cell. 1997 Apr 18; 89(2):287-96.
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  194. Price R, Robinson G, Brockman A, Cowman A, Krishna S. Assessment of pfmdr 1 gene copy number by tandem competitive polymerase chain reaction. Mol Biochem Parasitol. 1997 Apr; 85(2):161-9.
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  195. Desneves J, Thorn G, Berman A, Galatis D, La Greca N, Sinding J, Foley M, Deady LW, Cowman AF, Tilley L. Photoaffinity labeling of mefloquine-binding proteins in human serum, uninfected erythrocytes and Plasmodium falciparum-infected erythrocytes. Mol Biochem Parasitol. 1996 Nov 25; 82(2):181-94.
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  196. Riffkin CD, Chung R, Wall DM, Zalcberg JR, Cowman AF, Foley M, Tilley L. Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine. Biochem Pharmacol. 1996 Nov 22; 52(10):1545-52.
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  197. Bozdech Z, Delling U, Volkman SK, Cowman AF, Schurr E. Cloning and sequence analysis of a novel member of the ATP-binding cassette (ABC) protein gene family from Plasmodium falciparum. Mol Biochem Parasitol. 1996 Oct 18; 81(1):41-51.
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  198. Rubio JP, Thompson JK, Cowman AF. The var genes of Plasmodium falciparum are located in the subtelomeric region of most chromosomes. EMBO J. 1996 Aug 1; 15(15):4069-77.
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  199. Lim AS, Galatis D, Cowman AF. Plasmodium falciparum: amplification and overexpression of pfmdr1 is not necessary for increased mefloquine resistance. Exp Parasitol. 1996 Aug; 83(3):295-303.
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  200. Lim AS, Cowman AF. Plasmodium falciparum: chloroquine selection of a cloned line and DNA rearrangements. Exp Parasitol. 1996 Aug; 83(3):283-94.
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  201. Reeder JC, Rieckmann KH, Genton B, Lorry K, Wines B, Cowman AF. Point mutations in the dihydrofolate reductase and dihydropteroate synthetase genes and in vitro susceptibility to pyrimethamine and cycloguanil of Plasmodium falciparum isolates from Papua New Guinea. Am J Trop Med Hyg. 1996 Aug; 55(2):209-13.
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  202. Crabb BS, Cowman AF. Characterization of promoters and stable transfection by homologous and nonhomologous recombination in Plasmodium falciparum. Proc Natl Acad Sci U S A. 1996 Jul 9; 93(14):7289-94.
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  203. Dame JB, Arnot DE, Bourke PF, Chakrabarti D, Christodoulou Z, Coppel RL, Cowman AF, Craig AG, Fischer K, Foster J, Goodman N, Hinterberg K, Holder AA, Holt DC, Kemp DJ, Lanzer M, Lim A, Newbold CI, Ravetch JV, Reddy GR, Rubio J, Schuster SM, Su XZ, Thompson JK, Werner EB, et al. Current status of the Plasmodium falciparum genome project. Mol Biochem Parasitol. 1996 Jul; 79(1):1-12.
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  204. Rubio JP, Cowman AF. The ATP-binding cassette (ABC) gene family of Plasmodium falciparum. Parasitol Today. 1996 Apr; 12(4):135-40.
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  205. Cowman AF. Mechanisms of drug resistance in malaria. Aust N Z J Med. 1995 Dec; 25(6):837-44.
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  206. Trottein F, Triglia T, Cowman AF. Molecular cloning of a gene from Plasmodium falciparum that codes for a protein sharing motifs found in adhesive molecules from mammals and plasmodia. Mol Biochem Parasitol. 1995 Nov; 74(2):129-41.
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  207. Volkman SK, Cowman AF, Wirth DF. Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8921-5.
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  208. Waterkeyn JG, Lightowlers MW, Coppel R, Cowman AF. Characterization of the gene family encoding a host-protective antigen of the tapeworm Taenia ovis. Mol Biochem Parasitol. 1995 Jul; 73(1-2):123-31.
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  209. Trottein F, Thompson J, Cowman AF. Cloning of a new cation ATPase from Plasmodium falciparum: conservation of critical amino acids involved in calcium binding in mammalian organellar Ca(2+)-ATPases. Gene. 1995 May 26; 158(1):133-7.
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  210. Rubio JP, Triglia T, Kemp DJ, de Bruin D, Ravetch JV, Cowman AF. A YAC contig map of Plasmodium falciparum chromosome 4: characterization of a DNA amplification between two recently separated isolates. Genomics. 1995 Mar 20; 26(2):192-8.
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  211. Trottein F, Cowman AF. The primary structure of a putative phosphatidylethanolamine-binding protein from Plasmodium falciparum. Mol Biochem Parasitol. 1995 Mar; 70(1-2):235-9.
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  212. Trottein F, Cowman AF. Molecular cloning and sequence of two novel P-type adenosinetriphosphatases from Plasmodium falciparum. Eur J Biochem. 1995 Jan 15; 227(1-2):214-25.
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  213. Raynes K, Galatis D, Cowman AF, Tilley L, Deady LW. Synthesis and activity of some antimalarial bisquinolines. J Med Chem. 1995 Jan 6; 38(1):204-6.
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  214. Rubio JP, Cowman AF. Plasmodium falciparum: the pfmdr2 protein is not overexpressed in chloroquine-resistant isolates of the malaria parasite. Exp Parasitol. 1994 Sep; 79(2):137-47.
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  215. Triglia T, Cowman AF. Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7149-53.
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  216. Karcz SR, Herrmann VR, Trottein F, Cowman AF. Cloning and characterization of the vacuolar ATPase B subunit from Plasmodium falciparum. Mol Biochem Parasitol. 1994 May; 65(1):123-33.
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  217. van Es HH, Karcz S, Chu F, Cowman AF, Vidal S, Gros P, Schurr E. Expression of the plasmodial pfmdr1 gene in mammalian cells is associated with increased susceptibility to chloroquine. Mol Cell Biol. 1994 Apr; 14(4):2419-28.
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  218. Foley M, Deady LW, Ng K, Cowman AF, Tilley L. Photoaffinity labeling of chloroquine-binding proteins in Plasmodium falciparum. J Biol Chem. 1994 Mar 4; 269(9):6955-61.
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  219. Foote SJ, Cowman AF. The mode of action and the mechanism of resistance to antimalarial drugs. Acta Trop. 1994 Mar; 56(2-3):157-71.
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  220. Cowman AF, Galatis D, Thompson JK. Selection for mefloquine resistance in Plasmodium falciparum is linked to amplification of the pfmdr1 gene and cross-resistance to halofantrine and quinine. Proc Natl Acad Sci U S A. 1994 Feb 1; 91(3):1143-7.
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  221. Lim AS, Cowman AF. Phosphorylation of a P-glycoprotein homologue in Plasmodium falciparum. Mol Biochem Parasitol. 1993 Dec; 62(2):293-302.
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  222. Karcz SR, Herrmann VR, Cowman AF. Cloning and characterization of a vacuolar ATPase A subunit homologue from Plasmodium falciparum. Mol Biochem Parasitol. 1993 Apr; 58(2):333-44.
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  223. Karcz SR, Galatis D, Cowman AF. Nucleotide binding properties of a P-glycoprotein homologue from Plasmodium falciparum. Mol Biochem Parasitol. 1993 Apr; 58(2):269-76.
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  224. Cowman AF, Karcz S. Drug resistance and the P-glycoprotein homologues of Plasmodium falciparum. Semin Cell Biol. 1993 Feb; 4(1):29-35.
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  225. Cappai R, Kaslow DC, Peterson MG, Cowman AF, Anders RF, Kemp DJ. Cloning and analysis of the RESA-2 gene: a DNA homologue of the ring-infected erythrocyte surface antigen gene of Plasmodium falciparum. Mol Biochem Parasitol. 1992 Sep; 54(2):213-21.
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  226. Cappai R, Cowman AF. The Plasmodium falciparum hypoxanthine-guanine phosphoribosyl transferase gene has a 5' upstream intron. Mol Biochem Parasitol. 1992 Aug; 54(1):117-20.
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  227. Barnes DA, Foote SJ, Galatis D, Kemp DJ, Cowman AF. Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum. EMBO J. 1992 Aug; 11(8):3067-75.
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  228. Cowman AF, Galatis D. Plasmodium falciparum: the calmodulin gene is not amplified or overexpressed in chloroquine resistant or sensitive isolates. Exp Parasitol. 1991 Oct; 73(3):269-75.
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  229. Triglia T, Foote SJ, Kemp DJ, Cowman AF. Amplification of the multidrug resistance gene pfmdr1 in Plasmodium falciparum has arisen as multiple independent events. Mol Cell Biol. 1991 Oct; 11(10):5244-50.
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  230. Karcz S, Cowman AF. Similarities and differences between the multidrug resistance phenotype of mammalian tumor cells and chloroquine resistance in Plasmodium falciparum. Exp Parasitol. 1991 Aug; 73(2):233-40.
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  231. Cowman AF, Karcz S, Galatis D, Culvenor JG. A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole. J Cell Biol. 1991 Jun; 113(5):1033-42.
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  232. Cowman AF. The P-glycoprotein homologues of Plasmodium falciparum: Are they involved in chloroquine resistance? Parasitol Today. 1991 Apr; 7(4):70-6.
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  233. Cowman AF, Karcz SR. The pfmdr gene homologues of Plasmodium falciparum. Acta Leiden. 1991; 60(1):121-9.
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  234. Sirawaraporn W, Sirawaraporn R, Cowman AF, Yuthavong Y, Santi DV. Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum. Biochemistry. 1990 Dec 4; 29(48):10779-85.
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  235. Cowman AF, Lew AM. Chromosomal rearrangements and point mutations in the DHFR-TS gene of Plasmodium chabaudi under antifolate selection. Mol Biochem Parasitol. 1990 Aug; 42(1):21-9.
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  236. Cowman AF, Foote SJ. Chemotherapy and drug resistance in malaria. Int J Parasitol. 1990 Jul; 20(4):503-13.
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  237. Foote SJ, Kyle DE, Martin RK, Oduola AM, Forsyth K, Kemp DJ, Cowman AF. Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparum. Nature. 1990 May 17; 345(6272):255-8.
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  238. Foote SJ, Galatis D, Cowman AF. Amino acids in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum involved in cycloguanil resistance differ from those involved in pyrimethamine resistance. Proc Natl Acad Sci U S A. 1990 Apr; 87(8):3014-7.
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  239. Kemp DJ, Cowman AF, Walliker D. Genetic diversity in Plasmodium falciparum. Adv Parasitol. 1990; 29:75-149.
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  240. Cowman AF, Lew AM. Antifolate drug selection results in duplication and rearrangement of chromosome 7 in Plasmodium chabaudi. Mol Cell Biol. 1989 Nov; 9(11):5182-8.
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  241. Cappai R, van Schravendijk MR, Anders RF, Peterson MG, Thomas LM, Cowman AF, Kemp DJ. Expression of the RESA gene in Plasmodium falciparum isolate FCR3 is prevented by a subtelomeric deletion. Mol Cell Biol. 1989 Aug; 9(8):3584-7.
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  242. Foote SJ, Thompson JK, Cowman AF, Kemp DJ. Amplification of the multidrug resistance gene in some chloroquine-resistant isolates of P. falciparum. Cell. 1989 Jun 16; 57(6):921-30.
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  243. Cowman AF, Morry MJ, Biggs BA, Cross GA, Foote SJ. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):9109-13.
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  244. Saint RB, Coppel RL, Cowman AF, Brown GV, Shi PT, Barzaga N, Kemp DJ, Anders RF. Changes in repeat number, sequence, and reading frame in S-antigen genes of Plasmodium falciparum. Mol Cell Biol. 1987 Aug; 7(8):2968-73.
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  245. Gill AC, Cowman AF, Stewart NP, Kemp DJ, Timms P. Babesia bovis: molecular and biological characteristics of cloned parasite lines. Exp Parasitol. 1987 Apr; 63(2):180-8.
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  246. Zuker CS, Cowman AF, Rubin GM. Isolation and structure of a rhodopsin gene from D. melanogaster. Cell. 1985 Apr; 40(4):851-8.
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  247. Cowman AF, Saint RB, Coppel RL, Brown GV, Anders RF, Kemp DJ. Conserved sequences flank variable tandem repeats in two S-antigen genes of Plasmodium falciparum. Cell. 1985 Apr; 40(4):775-83.
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  248. Brown GV, Anders RF, Coppel RL, Saint RB, Cowman AF, Stahl HD, Lingelbach KR, Mitchell GF, Alpers MP, Kemp DJ. The expression of Plasmodium falciparum bloodstage antigens in Escherichia coli. Philos Trans R Soc Lond B Biol Sci. 1984 Nov 13; 307(1131):179-87.
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  249. Coppel RL, Cowman AF, Anders RF, Bianco AE, Saint RB, Lingelbach KR, Kemp DJ, Brown GV. Immune sera recognize on erythrocytes Plasmodium falciparum antigen composed of repeated amino acid sequences. Nature. 1984 Aug 30-Sep 5; 310(5980):789-92.
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  250. Cowman AF, Coppel RL, Saint RB, Favaloro J, Crewther PE, Stahl HD, Bianco AE, Brown GV, Anders RF, Kemp DJ. The ring-infected erythrocyte surface antigen (RESA) polypeptide of Plasmodium falciparum contains two separate blocks of tandem repeats encoding antigenic epitopes that are naturally immunogenic in man. Mol Biol Med. 1984 Jun; 2(3):207-21.
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  251. Anders RF, Coppel RL, Brown GV, Saint RB, Cowman AF, Lingelbach KR, Mitchell GF, Kemp DJ. Plasmodium falciparum complementary DNA clones expressed in Escherichia coli encode many distinct antigens. Mol Biol Med. 1984 Jun; 2(3):177-91.
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  252. Kemp DJ, Easton KE, Cowman AF. Accurate transcription of a cloned gene from Babesia bovis in Saccharomyces cerevisiae. Mol Biochem Parasitol. 1984 May; 12(1):61-7.
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  253. Stahl HD, Coppel RL, Brown GV, Saint R, Lingelbach K, Cowman AF, Anders RF, Kemp DJ. Differential antibody screening of cloned Plasmodium falciparum sequences expressed in Escherichia coli: procedure for isolation of defined antigens and analysis of human antisera. Proc Natl Acad Sci U S A. 1984 Apr; 81(8):2456-60.
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  254. Cowman AF, Timms P, Kemp DJ. DNA polymorphisms and subpopulations in Babesia bovis. Mol Biochem Parasitol. 1984 Apr; 11:91-103.
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  255. Coppel RL, Cowman AF, Lingelbach KR, Brown GV, Saint RB, Kemp DJ, Anders RF. Isolate-specific S-antigen of Plasmodium falciparum contains a repeated sequence of eleven amino acids. Nature. 1983 Dec 22-1984 Jan 4; 306(5945):751-6.
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  256. Kemp DJ, Coppel RL, Cowman AF, Saint RB, Brown GV, Anders RF. Expression of Plasmodium falciparum blood-stage antigens in Escherichia coli: detection with antibodies from immune humans. Proc Natl Acad Sci U S A. 1983 Jun; 80(12):3787-91.
    View in: PubMed
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