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Last Name
Institution

Alessandro Biffi, M.D.

TitleClinical Fellow in Neurology (EXT)
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Richard B. Simches Research Center-6
185 Cambridge St
Boston MA 02114
Phone617/726-5094
Fax617/726-5735

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Anderson CD, Biffi A, Nalls MA, Devan WJ, Schwab K, Ayres AM, Valant V, Ross OA, Rost NS, Saxena R, Viswanathan A, Worrall BB, Brott TG, Goldstein JN, Brown D, Broderick JP, Norrving B, Greenberg SM, Silliman SL, Hansen BM, Tirschwell DL, Lindgren A, Slowik A, Schmidt R, Selim M, Roquer J, Montaner J, Singleton AB, Kidwell CS, Woo D, Furie KL, Meschia JF, Rosand J. Common variants within oxidative phosphorylation genes influence risk of ischemic stroke and intracerebral hemorrhage. Stroke. 2013 Mar; 44(3):612-9.
    View in: PubMed
  2. Falcone GJ, Biffi A, Devan WJ, Brouwers HB, Anderson CD, Valant V, Ayres AM, Schwab K, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Selim M, Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Rosand J. Burden of blood pressure-related alleles is associated with larger hematoma volume and worse outcome in intracerebral hemorrhage. Stroke. 2013 Feb; 44(2):321-6.
    View in: PubMed
  3. Giada F, Santomauro M, Biffi A, Casasco M. [Early defibrillation with automated external defibrillators during sports events]. G Ital Cardiol (Rome). 2012 Oct; 13(10 Suppl 2):109-12.
    View in: PubMed
  4. Falcone GJ, Biffi A, Devan WJ, Jagiella JM, Schmidt H, Kissela B, Hansen BM, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, Ayres AM, Schwab K, Pera J, Urbanik A, Rost NS, Goldstein JN, Viswanathan A, Pichler A, Enzinger C, Norrving B, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernandez-Cadenas I, Delgado P, Broderick JP, Greenberg SM, Roquer J, Lindgren A, Slowik A, Schmidt R, Flaherty ML, Kleindorfer DO, Langefeld CD, Woo D, Rosand J. Burden of risk alleles for hypertension increases risk of intracerebral hemorrhage. Stroke. 2012 Nov; 43(11):2877-83.
    View in: PubMed
  5. Brouwers HB, Biffi A, McNamara KA, Ayres AM, Valant V, Schwab K, Romero JM, Viswanathan A, Greenberg SM, Rosand J, Goldstein JN. Apolipoprotein E genotype is associated with CT angiography spot sign in lobar intracerebral hemorrhage. Stroke. 2012 Aug; 43(8):2120-5.
    View in: PubMed
  6. Brouwers HB, Biffi A, Ayres AM, Schwab K, Cortellini L, Romero JM, Rost NS, Viswanathan A, Greenberg SM, Rosand J, Goldstein JN. Apolipoprotein E genotype predicts hematoma expansion in lobar intracerebral hemorrhage. Stroke. 2012 Jun; 43(6):1490-5.
    View in: PubMed
  7. Weng YC, Sonni A, Labelle-Dumais C, de Leau M, Kauffman WB, Jeanne M, Biffi A, Greenberg SM, Rosand J, Gould DB. COL4A1 mutations in patients with sporadic late-onset intracerebral hemorrhage. Ann Neurol. 2012 Apr; 71(4):470-7.
    View in: PubMed
  8. Cheng YC, Anderson CD, Bione S, Keene K, Maguire JM, Nalls M, Rasheed A, Zeginigg M, Attia J, Baker R, Barlera S, Biffi A, Bookman E, Brott TG, Brown RD, Chen F, Chen WM, Ciusani E, Cole JW, Cortellini L, Danesh J, Doheny K, Ferrucci L, Grazia Franzosi M, Frossard P, Furie KL, Golledge J, Hankey GJ, Hernandez D, Holliday EG, Hsu FC, Jannes J, Kamal A, Khan MS, Kittner SJ, Koblar SA, Lewis M, Lincz L, Lisa A, Matarin M, Moscato P, Mychaleckyj JC, Parati EA, Parolo S, Pugh E, Rost NS, Schallert M, Schmidt H, Scott RJ, Sturm JW, Yadav S, Zaidi M, Boncoraglio GB, Levi CR, Meschia JF, Rosand J, Sale M, Saleheen D, Schmidt R, Sharma P, Worrall B, Mitchell BD. Are myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke? Stroke. 2012 Apr; 43(4):980-6.
    View in: PubMed
  9. Herrington WG. Statin use and outcome after intracerebral hemorrhage: case-control study and meta-analysis. Neurology. 2011 Dec 6; 77(23):2073; author reply 2073-4.
    View in: PubMed
  10. Anderson CD, Bartscher JF, Scripko PD, Biffi A, Chase D, Guanci M, Greer DM. Neurologic examination and extubation outcome in the neurocritical care unit. Neurocrit Care. 2011 Dec; 15(3):490-7.
    View in: PubMed
  11. Rost NS, Biffi A, Cloonan L, Chorba J, Kelly P, Greer D, Ellinor P, Furie KL. Brain natriuretic peptide predicts functional outcome in ischemic stroke. Stroke. 2012 Feb; 43(2):441-5.
    View in: PubMed
  12. De Jager PL, Shulman JM, Chibnik LB, Keenan BT, Raj T, Wilson RS, Yu L, Leurgans SE, Tran D, Aubin C, Anderson CD, Biffi A, Corneveaux JJ, Huentelman MJ, Rosand J, Daly MJ, Myers AJ, Reiman EM, Bennett DA, Evans DA. A genome-wide scan for common variants affecting the rate of age-related cognitive decline. Neurobiol Aging. 2012 May; 33(5):1017.e1-15.
    View in: PubMed
  13. Cheng YC, O'Connell JR, Cole JW, Stine OC, Dueker N, McArdle PF, Sparks MJ, Shen J, Laurie CC, Nelson S, Doheny KF, Ling H, Pugh EW, Brott TG, Brown RD, Meschia JF, Nalls M, Rich SS, Worrall B, Anderson CD, Biffi A, Cortellini L, Furie KL, Rost NS, Rosand J, Manolio TA, Kittner SJ, Mitchell BD. Genome-wide association analysis of ischemic stroke in young adults. G3 (Bethesda). 2011 Nov; 1(6):505-14.
    View in: PubMed
  14. Biffi A, Cortellini L, Nearnberg CM, Ayres AM, Schwab K, Gilson AJ, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Rosand J. Body mass index and etiology of intracerebral hemorrhage. Stroke. 2011 Sep; 42(9):2526-30.
    View in: PubMed
  15. Biffi A, Anderson CD, Jagiella JM, Schmidt H, Kissela B, Hansen BM, Jimenez-Conde J, Pires CR, Ayres AM, Schwab K, Cortellini L, Pera J, Urbanik A, Romero JM, Rost NS, Goldstein JN, Viswanathan A, Pichler A, Enzinger C, Rabionet R, Norrving B, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Broderick JP, Greenberg SM, Roquer J, Lindgren A, Slowik A, Schmidt R, Woo D, Rosand J. APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study. Lancet Neurol. 2011 Aug; 10(8):702-9.
    View in: PubMed
  16. Nalls MA, Couper DJ, Tanaka T, van Rooij FJ, Chen MH, Smith AV, Toniolo D, Zakai NA, Yang Q, Greinacher A, Wood AR, Garcia M, Gasparini P, Liu Y, Lumley T, Folsom AR, Reiner AP, Gieger C, Lagou V, Felix JF, Völzke H, Gouskova NA, Biffi A, Döring A, Völker U, Chong S, Wiggins KL, Rendon A, Dehghan A, Moore M, Taylor K, Wilson JG, Lettre G, Hofman A, Bis JC, Pirastu N, Fox CS, Meisinger C, Sambrook J, Arepalli S, Nauck M, Prokisch H, Stephens J, Glazer NL, Cupples LA, Okada Y, Takahashi A, Kamatani Y, Matsuda K, Tsunoda T, Tanaka T, Kubo M, Nakamura Y, Yamamoto K, Kamatani N, Stumvoll M, Tönjes A, Prokopenko I, Illig T, Patel KV, Garner SF, Kuhnel B, Mangino M, Oostra BA, Thein SL, Coresh J, Wichmann HE, Menzel S, Lin J, Pistis G, Uitterlinden AG, Spector TD, Teumer A, Eiriksdottir G, Gudnason V, Bandinelli S, Frayling TM, Chakravarti A, van Duijn CM, Melzer D, Ouwehand WH, Levy D, Boerwinkle E, Singleton AB, Hernandez DG, Longo DL, Soranzo N, Witteman JC, Psaty BM, Ferrucci L, Harris TB, O'Donnell CJ, Ganesh SK. Multiple loci are associated with white blood cell phenotypes. PLoS Genet. 2011 Jun; 7(6):e1002113.
    View in: PubMed
  17. Tranah GJ, Manini TM, Lohman KK, Nalls MA, Kritchevsky S, Newman AB, Harris TB, Miljkovic I, Biffi A, Cummings SR, Liu Y. Mitochondrial DNA variation in human metabolic rate and energy expenditure. Mitochondrion. 2011 Nov; 11(6):855-61.
    View in: PubMed
  18. Biffi A, Greenberg SM. Cerebral amyloid angiopathy: a systematic review. J Clin Neurol. 2011 Mar; 7(1):1-9.
    View in: PubMed
  19. Biffi A, Devan WJ, Anderson CD, Cortellini L, Furie KL, Rosand J, Rost NS. Statin treatment and functional outcome after ischemic stroke: case-control and meta-analysis. Stroke. 2011 May; 42(5):1314-9.
    View in: PubMed
  20. Delise P, Lanari E, Sitta N, Centa M, Allocca G, Biffi A. Influence of training on the number and complexity of frequent VPBs in healthy athletes. J Cardiovasc Med (Hagerstown). 2011 Mar; 12(3):157-61.
    View in: PubMed
  21. Biffi A, Maron BJ, Culasso F, Verdile L, Fernando F, Di Giacinto B, Di Paolo FM, Spataro A, Delise P, Pelliccia A. Patterns of ventricular tachyarrhythmias associated with training, deconditioning and retraining in elite athletes without cardiovascular abnormalities. Am J Cardiol. 2011 Mar 1; 107(5):697-703.
    View in: PubMed
  22. Anderson CD, Nalls MA, Biffi A, Rost NS, Greenberg SM, Singleton AB, Meschia JF, Rosand J. The effect of survival bias on case-control genetic association studies of highly lethal diseases. Circ Cardiovasc Genet. 2011 Apr; 4(2):188-96.
    View in: PubMed
  23. Biffi A, Sonni A, Anderson CD, Kissela B, Jagiella JM, Schmidt H, Jimenez-Conde J, Hansen BM, Fernandez-Cadenas I, Cortellini L, Ayres A, Schwab K, Juchniewicz K, Urbanik A, Rost NS, Viswanathan A, Seifert-Held T, Stoegerer EM, Tomás M, Rabionet R, Estivill X, Brown DL, Silliman SL, Selim M, Worrall BB, Meschia JF, Montaner J, Lindgren A, Roquer J, Schmidt R, Greenberg SM, Slowik A, Broderick JP, Woo D, Rosand J. Variants at APOE influence risk of deep and lobar intracerebral hemorrhage. Ann Neurol. 2010 Dec; 68(6):934-43.
    View in: PubMed
  24. Biffi A, Plourde A, Shen Y, Onofrio R, Smith EE, Frosch M, Prada CM, Gusella J, Greenberg SM, Rosand J. Screening for familial APP mutations in sporadic cerebral amyloid angiopathy. PLoS One. 2010; 5(11):e13949.
    View in: PubMed
  25. Anderson CD, Biffi A, Greenberg SM, Rosand J. Personalized approaches to clopidogrel therapy: are we there yet? Stroke. 2010 Dec; 41(12):2997-3002.
    View in: PubMed
  26. Rost NS, Fitzpatrick K, Biffi A, Kanakis A, Devan W, Anderson CD, Cortellini L, Furie KL, Rosand J. White matter hyperintensity burden and susceptibility to cerebral ischemia. Stroke. 2010 Dec; 41(12):2807-11.
    View in: PubMed
  27. Giada F, Biffi A, Cannom DS, Cappato R, Capucci A, Corrado D, Delise P, Drezner JA, El-Sherif N, Estes M, Furlanello F, Heidbuchel H, Inama G, Lindsay BD, Maron BJ, Maron MS, Mont L, Olshansky B, Pelliccia A, Thiene G, Viskin S, Zeppilli P, Natale A, Raviele A. Sports and arrhythmias: a report of the International Workshop Venice Arrhythmias 2009. Eur J Cardiovasc Prev Rehabil. 2010 Oct; 17(5):607-12.
    View in: PubMed
  28. Desikan RS, Sabuncu MR, Schmansky NJ, Reuter M, Cabral HJ, Hess CP, Weiner MW, Biffi A, Anderson CD, Rosand J, Salat DH, Kemper TL, Dale AM, Sperling RA, Fischl B. Selective disruption of the cerebral neocortex in Alzheimer's disease. PLoS One. 2010; 5(9):e12853.
    View in: PubMed
  29. Anderson CD, Biffi A, Rahman R, Ross OA, Jagiella JM, Kissela B, Cole JW, Cortellini L, Rost NS, Cheng YC, Greenberg SM, de Bakker PI, Brown RD, Brott TG, Mitchell BD, Broderick JP, Worrall BB, Furie KL, Kittner SJ, Woo D, Slowik A, Meschia JF, Saxena R, Rosand J. Common mitochondrial sequence variants in ischemic stroke. Ann Neurol. 2011 Mar; 69(3):471-80.
    View in: PubMed
  30. Biffi A, Anderson CD, Desikan RS, Sabuncu M, Cortellini L, Schmansky N, Salat D, Rosand J. Genetic variation and neuroimaging measures in Alzheimer disease. Arch Neurol. 2010 Jun; 67(6):677-85.
    View in: PubMed
  31. Biffi A, Anderson CD, Nalls MA, Rahman R, Sonni A, Cortellini L, Rost NS, Matarin M, Hernandez DG, Plourde A, de Bakker PI, Ross OA, Greenberg SM, Furie KL, Meschia JF, Singleton AB, Saxena R, Rosand J. Principal-component analysis for assessment of population stratification in mitochondrial medical genetics. Am J Hum Genet. 2010 Jun 11; 86(6):904-17.
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  32. Rost NS, Rahman R, Sonni S, Kanakis A, Butler C, Massasa E, Cloonan L, Gilson A, Delgado P, Chang Y, Biffi A, Jimenez-Conde J, Besanger A, Silva G, Smith EE, Rosand J, Furie KL. Determinants of white matter hyperintensity volume in patients with acute ischemic stroke. J Stroke Cerebrovasc Dis. 2010 May; 19(3):230-5.
    View in: PubMed
  33. Anderson CD, Biffi A, Rost NS, Cortellini L, Furie KL, Rosand J. Chromosome 9p21 in ischemic stroke: population structure and meta-analysis. Stroke. 2010 Jun; 41(6):1123-31.
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  34. Jimenez-Conde J, Biffi A, Rahman R, Kanakis A, Butler C, Sonni S, Massasa E, Cloonan L, Gilson A, Capozzo K, Cortellini L, Ois A, Cuadrado-Godia E, Rodriguez-Campello A, Furie KL, Roquer J, Rosand J, Rost NS. Hyperlipidemia and reduced white matter hyperintensity volume in patients with ischemic stroke. Stroke. 2010 Mar; 41(3):437-42.
    View in: PubMed
  35. Corrado D, Pelliccia A, Heidbuchel H, Sharma S, Link M, Basso C, Biffi A, Buja G, Delise P, Gussac I, Anastasakis A, Borjesson M, Bjørnstad HH, Carrè F, Deligiannis A, Dugmore D, Fagard R, Hoogsteen J, Mellwig KP, Panhuyzen-Goedkoop N, Solberg E, Vanhees L, Drezner J, Estes NA, Iliceto S, Maron BJ, Peidro R, Schwartz PJ, Stein R, Thiene G, Zeppilli P, McKenna WJ. Recommendations for interpretation of 12-lead electrocardiogram in the athlete. Eur Heart J. 2010 Jan; 31(2):243-59.
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  36. Rigolio R, Biffi A, Oggioni N, Cavaletti G. Actively induced EAE in Lewis rats: characterization of spleen and spinal cord infiltrating lymphocytes by flow cytometry during the course of the disease. J Neuroimmunol. 2008 Aug 13; 199(1-2):67-74.
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  37. Giada F, Biffi A, Agostoni P, Anedda A, Belardinelli R, Carlon R, Carù B, D'Andrea L, Delise P, De Francesco A, Fattirolli F, Guglielmi R, Guiducci U, Pelliccia A, Penco M, Perticone F, Thiene G, Vona M, Zeppilli P. Exercise prescription for the prevention and treatment of cardiovascular diseases: part II. J Cardiovasc Med (Hagerstown). 2008 Jun; 9(6):641-52.
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  38. Giada F, Biffi A, Agostoni P, Anedda A, Belardinelli R, Carlon R, Carù B, D'Andrea L, Delise P, De Francesco A, Fattirolli F, Guglielmi R, Guiducci U, Pelliccia A, Penco M, Perticone F, Thiene G, Vona M, Zeppilli P. Exercise prescription for the prevention and treatment of cardiovascular diseases: part I. J Cardiovasc Med (Hagerstown). 2008 May; 9(5):529-44.
    View in: PubMed
  39. Biffi A, Maron BJ, Di Giacinto B, Porcacchia P, Verdile L, Fernando F, Spataro A, Culasso F, Casasco M, Pelliccia A. Relation between training-induced left ventricular hypertrophy and risk for ventricular tachyarrhythmias in elite athletes. Am J Cardiol. 2008 Jun 15; 101(12):1792-5.
    View in: PubMed
  40. Pelliccia A, Di Paolo FM, Quattrini FM, Basso C, Culasso F, Popoli G, De Luca R, Spataro A, Biffi A, Thiene G, Maron BJ. Outcomes in athletes with marked ECG repolarization abnormalities. N Engl J Med. 2008 Jan 10; 358(2):152-61.
    View in: PubMed
  41. Giada F, Barold SS, Biffi A, De Piccoli B, Delise P, El-Sherif N, Gold MR, Gorenek B, Grubb B, Inama G, Kautzner J, Molina L, Olshansky B, Pelliccia A, Thiene G, Wellens H, Wolpert C, Zeppilli P, Raviele A, Heidbuchel H. Sport and arrhythmias: summary of an international symposium. Eur J Cardiovasc Prev Rehabil. 2007 Oct; 14(5):707-14.
    View in: PubMed
  42. Biffi A. How to manage athletes with ventricular arrhythmias. Cardiol Clin. 2007 Aug; 25(3):449-55, vii.
    View in: PubMed
  43. Giada F, Carlon R, Biffi A, Agostoni P, Anedda A, Belardinelli R, Bettini R, Carù B, D'Andrea L, Delise P, de Francesco A, Fattirolli F, Guglielmi R, Guiducci U, Notaristefano A, Pelliccia A, Penco M, Perticone F, Thiene G, Vona M, Zeppilli P. [Consensus statement of Multisocietary Task Force--prescription of physical exercise in the cardiological environment (First part)]. Monaldi Arch Chest Dis. 2007 Mar; 68(1):13-30.
    View in: PubMed
  44. Pelliccia A, Di Paolo FM, Corrado D, Buccolieri C, Quattrini FM, Pisicchio C, Spataro A, Biffi A, Granata M, Maron BJ. Evidence for efficacy of the Italian national pre-participation screening programme for identification of hypertrophic cardiomyopathy in competitive athletes. Eur Heart J. 2006 Sep; 27(18):2196-200.
    View in: PubMed
  45. Biffi A. Idiopathic ventricular arrhythmias in athletes: their causes and when to grant sports eligibility. J Cardiovasc Med (Hagerstown). 2006 Apr; 7(4):279-81.
    View in: PubMed
  46. Pelliccia A, Maron BJ, Di Paolo FM, Biffi A, Quattrini FM, Pisicchio C, Roselli A, Caselli S, Culasso F. Prevalence and clinical significance of left atrial remodeling in competitive athletes. J Am Coll Cardiol. 2005 Aug 16; 46(4):690-6.
    View in: PubMed
  47. Pelliccia A, Fagard R, Bjørnstad HH, Anastassakis A, Arbustini E, Assanelli D, Biffi A, Borjesson M, Carrè F, Corrado D, Delise P, Dorwarth U, Hirth A, Heidbuchel H, Hoffmann E, Mellwig KP, Panhuyzen-Goedkoop N, Pisani A, Solberg EE, van-Buuren F, Vanhees L, Blomstrom-Lundqvist C, Deligiannis A, Dugmore D, Glikson M, Hoff PI, Hoffmann A, Hoffmann E, Horstkotte D, Nordrehaug JE, Oudhof J, McKenna WJ, Penco M, Priori S, Reybrouck T, Senden J, Spataro A, Thiene G. Recommendations for competitive sports participation in athletes with cardiovascular disease: a consensus document from the Study Group of Sports Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology. Eur Heart J. 2005 Jul; 26(14):1422-45.
    View in: PubMed
  48. Corrado D, Pelliccia A, Bjørnstad HH, Vanhees L, Biffi A, Borjesson M, Panhuyzen-Goedkoop N, Deligiannis A, Solberg E, Dugmore D, Mellwig KP, Assanelli D, Delise P, van-Buuren F, Anastasakis A, Heidbuchel H, Hoffmann E, Fagard R, Priori SG, Basso C, Arbustini E, Blomstrom-Lundqvist C, McKenna WJ, Thiene G. Cardiovascular pre-participation screening of young competitive athletes for prevention of sudden death: proposal for a common European protocol. Consensus Statement of the Study Group of Sport Cardiology of the Working Group of Cardiac Rehabilitation and Exercise Physiology and the Working Group of Myocardial and Pericardial Diseases of the European Society of Cardiology. Eur Heart J. 2005 Mar; 26(5):516-24.
    View in: PubMed
  49. Biffi A, Maron BJ, Verdile L, Fernando F, Spataro A, Marcello G, Ciardo R, Ammirati F, Colivicchi F, Pelliccia A. Impact of physical deconditioning on ventricular tachyarrhythmias in trained athletes. J Am Coll Cardiol. 2004 Sep 1; 44(5):1053-8.
    View in: PubMed
  50. Biffi A, Pelliccia A, Verdile L, Fernando F, Spataro A, Caselli S, Santini M, Maron BJ. Long-term clinical significance of frequent and complex ventricular tachyarrhythmias in trained athletes. J Am Coll Cardiol. 2002 Aug 7; 40(3):446-52.
    View in: PubMed
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