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Matti S. Hamalainen, PH.D.

TitleAssociate Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
Radiology 1st Floor Room 1111, 149-2301
149 13th Street
Charlestown MA 02129
Phone617/726-0323
Fax617/726-7422
Other Positions
TitleMember of the Affiliated Faculty of the Harvard-MIT Division of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lamus C, Hämäläinen MS, Temereanca S, Brown EN, Purdon PL. A spatiotemporal dynamic distributed solution to the MEG inverse problem. Neuroimage. 2012 Nov 1; 63(2):894-909.
    View in: PubMed
  2. Agam Y, Hämäläinen MS, Lee AK, Dyckman KA, Friedman JS, Isom M, Makris N, Manoach DS. Multimodal neuroimaging dissociates hemodynamic and electrophysiological correlates of error processing. Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17556-61.
    View in: PubMed
  3. Shiraishi H, Ahlfors SP, Stufflebeam SM, Knake S, Larsson PG, Hämäläinen MS, Takano K, Okajima M, Hatanaka K, Saitoh S, Dale AM, Halgren E. Comparison of three methods for localizing interictal epileptiform discharges with magnetoencephalography. J Clin Neurophysiol. 2011 Oct; 28(5):431-40.
    View in: PubMed
  4. Tanaka N, Grant PE, Suzuki N, Madsen JR, Bergin AM, Hämäläinen MS, Stufflebeam SM. Multimodal imaging of spike propagation: a technical case report. AJNR Am J Neuroradiol. 2012 Jun; 33(6):E82-4.
    View in: PubMed
  5. Ciesielski KT, Rauch SL, Ahlfors SP, Vangel ME, Wilhelm S, Rosen BR, Hämäläinen MS. Role of medial cortical networks for anticipatory processing in obsessive-compulsive disorder. Hum Brain Mapp. 2012 Sep; 33(9):2125-34.
    View in: PubMed
  6. Witzel T, Napadow V, Kettner NW, Vangel MG, Hämäläinen MS, Dhond RP. Differences in cortical response to acupressure and electroacupuncture stimuli. BMC Neurosci. 2011; 12:73.
    View in: PubMed
  7. Chen WT, Lin YY, Fuh JL, Hämäläinen MS, Ko YC, Wang SJ. Sustained visual cortex hyperexcitability in migraine with persistent visual aura. Brain. 2011 Aug; 134(Pt 8):2387-95.
    View in: PubMed
  8. Long CJ, Purdon PL, Temereanca S, Desai NU, Hämäläinen MS, Brown EN. STATE-SPACE SOLUTIONS TO THE DYNAMIC MAGNETOENCEPHALOGRAPHY INVERSE PROBLEM USING HIGH PERFORMANCE COMPUTING. Ann Appl Stat. 2011 Jun 1; 5(2B):1207-1228.
    View in: PubMed
  9. Kerr CE, Jones SR, Wan Q, Pritchett DL, Wasserman RH, Wexler A, Villanueva JJ, Shaw JR, Lazar SW, Kaptchuk TJ, Littenberg R, Hämäläinen MS, Moore CI. Effects of mindfulness meditation training on anticipatory alpha modulation in primary somatosensory cortex. Brain Res Bull. 2011 May 30; 85(3-4):96-103.
    View in: PubMed
  10. Kveraga K, Ghuman AS, Kassam KS, Aminoff EA, Hämäläinen MS, Chaumon M, Bar M. Early onset of neural synchronization in the contextual associations network. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3389-94.
    View in: PubMed
  11. Gramfort A, Strohmeier D, Haueisen J, Hamalainen M, Kowalski M. Functional brain imaging with M/EEG using structured sparsity in time-frequency dictionaries. Inf Process Med Imaging. 2011; 22:600-11.
    View in: PubMed
  12. Luck SJ, Mathalon DH, O'Donnell BF, Hämäläinen MS, Spencer KM, Javitt DC, Uhlhaas PJ. A roadmap for the development and validation of event-related potential biomarkers in schizophrenia research. Biol Psychiatry. 2011 Jul 1; 70(1):28-34.
    View in: PubMed
  13. Ciesielski KT, Ahlfors SP, Bedrick EJ, Kerwin AA, Hämäläinen MS. Top-down control of MEG alpha-band activity in children performing Categorical N-Back Task. Neuropsychologia. 2010 Oct; 48(12):3573-9.
    View in: PubMed
  14. Ahlfors SP, Han J, Belliveau JW, Hämäläinen MS. Sensitivity of MEG and EEG to source orientation. Brain Topogr. 2010 Sep; 23(3):227-32.
    View in: PubMed
  15. Lee AK, Hämäläinen MS, Dyckman KA, Barton JJ, Manoach DS. Saccadic preparation in the frontal eye field is modulated by distinct trial history effects as revealed by magnetoencephalography. Cereb Cortex. 2011 Feb; 21(2):245-53.
    View in: PubMed
  16. Ou W, Nummenmaa A, Ahveninen J, Belliveau JW, Hämäläinen MS, Golland P. Multimodal functional imaging using fMRI-informed regional EEG/MEG source estimation. Neuroimage. 2010 Aug 1; 52(1):97-108.
    View in: PubMed
  17. Gutschalk A, Hämäläinen MS, Melcher JR. BOLD responses in human auditory cortex are more closely related to transient MEG responses than to sustained ones. J Neurophysiol. 2010 Apr; 103(4):2015-26.
    View in: PubMed
  18. Ahlfors SP, Han J, Lin FH, Witzel T, Belliveau JW, Hämäläinen MS, Halgren E. Cancellation of EEG and MEG signals generated by extended and distributed sources. Hum Brain Mapp. 2010 Jan; 31(1):140-9.
    View in: PubMed
  19. Tanaka N, Hämäläinen MS, Ahlfors SP, Liu H, Madsen JR, Bourgeois BF, Lee JW, Dworetzky BA, Belliveau JW, Stufflebeam SM. Propagation of epileptic spikes reconstructed from spatiotemporal magnetoencephalographic and electroencephalographic source analysis. Neuroimage. 2010 Mar; 50(1):217-22.
    View in: PubMed
  20. Weiss AP, Ellis CB, Roffman JL, Stufflebeam S, Hamalainen MS, Duff M, Goff DC, Schacter DL. Aberrant frontoparietal function during recognition memory in schizophrenia: a multimodal neuroimaging investigation. J Neurosci. 2009 Sep 9; 29(36):11347-59.
    View in: PubMed
  21. Mosher JC, Hämäläinen MS, Pantazis D, Hui HB, Burgess RC, Leahy RM. GENERALIZED SIDELOBE CANCELLER FOR MAGNETOENCEPHALOGRAPHY ARRAYS. Proc IEEE Int Symp Biomed Imaging. 2009 Aug 7; 2009:149-152.
    View in: PubMed
  22. Lin FH, Hara K, Solo V, Vangel M, Belliveau JW, Stufflebeam SM, Hämäläinen MS. Dynamic Granger-Geweke causality modeling with application to interictal spike propagation. Hum Brain Mapp. 2009 Jun; 30(6):1877-86.
    View in: PubMed
  23. Tanaka N, Cole AJ, von Pechmann D, Wakeman DG, Hämäläinen MS, Liu H, Madsen JR, Bourgeois BF, Stufflebeam SM. Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy. Epilepsy Res. 2009 Aug; 85(2-3):279-86.
    View in: PubMed
  24. Goldenholz DM, Ahlfors SP, Hämäläinen MS, Sharon D, Ishitobi M, Vaina LM, Stufflebeam SM. Mapping the signal-to-noise-ratios of cortical sources in magnetoencephalography and electroencephalography. Hum Brain Mapp. 2009 Apr; 30(4):1077-86.
    View in: PubMed
  25. Auranen T, Nummenmaa A, Vanni S, Vehtari A, Hämäläinen MS, Lampinen J, Jääskeläinen IP. Automatic fMRI-guided MEG multidipole localization for visual responses. Hum Brain Mapp. 2009 Apr; 30(4):1087-99.
    View in: PubMed
  26. Ou W, Nissilä I, Radhakrishnan H, Boas DA, Hämäläinen MS, Franceschini MA. Study of neurovascular coupling in humans via simultaneous magnetoencephalography and diffuse optical imaging acquisition. Neuroimage. 2009 Jul 1; 46(3):624-32.
    View in: PubMed
  27. Ou W, Nummenmaa A, Golland P, Hamalainen MS. Multimodal functional imaging using fMRI-informed regional EEG/MEG source estimation. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:1926-9.
    View in: PubMed
  28. Meeren HK, Hadjikhani N, Ahlfors SP, Hämäläinen MS, de Gelder B. Early category-specific cortical activation revealed by visual stimulus inversion. PLoS One. 2008; 3(10):e3503.
    View in: PubMed
  29. Dhond RP, Witzel T, Hämäläinen M, Kettner N, Napadow V. Spatiotemporal mapping the neural correlates of acupuncture with MEG. J Altern Complement Med. 2008 Jul; 14(6):679-88.
    View in: PubMed
  30. Molins A, Stufflebeam SM, Brown EN, Hämäläinen MS. Quantification of the benefit from integrating MEG and EEG data in minimum l2-norm estimation. Neuroimage. 2008 Sep 1; 42(3):1069-77.
    View in: PubMed
  31. Ou W, Hämäläinen MS, Golland P. A distributed spatio-temporal EEG/MEG inverse solver. Neuroimage. 2009 Feb 1; 44(3):932-46.
    View in: PubMed
  32. Stufflebeam SM, Witzel T, Mikulski S, Hämäläinen MS, Temereanca S, Barton JJ, Tuch DS, Manoach DS. A non-invasive method to relate the timing of neural activity to white matter microstructural integrity. Neuroimage. 2008 Aug 15; 42(2):710-6.
    View in: PubMed
  33. Raij T, Karhu J, Kicic D, Lioumis P, Julkunen P, Lin FH, Ahveninen J, Ilmoniemi RJ, Mäkelä JP, Hämäläinen M, Rosen BR, Belliveau JW. Parallel input makes the brain run faster. Neuroimage. 2008 May 1; 40(4):1792-7.
    View in: PubMed
  34. Wehner DT, Hämäläinen MS, Mody M, Ahlfors SP. Head movements of children in MEG: quantification, effects on source estimation, and compensation. Neuroimage. 2008 Apr 1; 40(2):541-50.
    View in: PubMed
  35. Ciesielski KT, Hämäläinen MS, Geller DA, Wilhelm S, Goldsmith TE, Ahlfors SP. Dissociation between MEG alpha modulation and performance accuracy on visual working memory task in obsessive compulsive disorder. Hum Brain Mapp. 2007 Dec; 28(12):1401-14.
    View in: PubMed
  36. Lin FH, Wang FN, Ahlfors SP, Hämäläinen MS, Belliveau JW. Parallel MRI reconstruction using variance partitioning regularization. Magn Reson Med. 2007 Oct; 58(4):735-44.
    View in: PubMed
  37. Auranen T, Nummenmaa A, Hämäläinen MS, Jääskeläinen IP, Lampinen J, Vehtari A, Sams M. Bayesian inverse analysis of neuromagnetic data using cortically constrained multiple dipoles. Hum Brain Mapp. 2007 Oct; 28(10):979-94.
    View in: PubMed
  38. Lamus C, Long CJ, Hämäläinen MS, Brown EN, Purdon PL. PARAMETER ESTIMATION AND DYNAMIC SOURCE LOCALIZATION FOR THE MAGNETOENCEPHALOGRAPHY (MEG) INVERSE PROBLEM. Proc IEEE Int Symp Biomed Imaging. 2007 May 15; 2007:1092-1095.
    View in: PubMed
  39. Moon SY, Barton JJ, Mikulski S, Polli FE, Cain MS, Vangel M, Hämäläinen MS, Manoach DS. Where left becomes right: a magnetoencephalographic study of sensorimotor transformation for antisaccades. Neuroimage. 2007 Jul 15; 36(4):1313-23.
    View in: PubMed
  40. Sharon D, Hämäläinen MS, Tootell RB, Halgren E, Belliveau JW. The advantage of combining MEG and EEG: comparison to fMRI in focally stimulated visual cortex. Neuroimage. 2007 Jul 15; 36(4):1225-35.
    View in: PubMed
  41. Nummenmaa A, Auranen T, Hämäläinen MS, Jääskeläinen IP, Sams M, Vehtari A, Lampinen J. Automatic relevance determination based hierarchical Bayesian MEG inversion in practice. Neuroimage. 2007 Sep 1; 37(3):876-89.
    View in: PubMed
  42. Nummenmaa A, Auranen T, Hämäläinen MS, Jääskeläinen IP, Lampinen J, Sams M, Vehtari A. Hierarchical Bayesian estimates of distributed MEG sources: theoretical aspects and comparison of variational and MCMC methods. Neuroimage. 2007 Apr 1; 35(2):669-85.
    View in: PubMed
  43. Ahveninen J, Lin FH, Kivisaari R, Autti T, Hämäläinen M, Stufflebeam S, Belliveau JW, Kähkönen S. MRI-constrained spectral imaging of benzodiazepine modulation of spontaneous neuromagnetic activity in human cortex. Neuroimage. 2007 Apr 1; 35(2):577-82.
    View in: PubMed
  44. Ou W, Golland P, Hämäläinen M. Sources of variability in MEG. Med Image Comput Comput Assist Interv. 2007; 10(Pt 2):751-9.
    View in: PubMed
  45. Lin FH, Wald LL, Ahlfors SP, Hämäläinen MS, Kwong KK, Belliveau JW. Dynamic magnetic resonance inverse imaging of human brain function. Magn Reson Med. 2006 Oct; 56(4):787-802.
    View in: PubMed
  46. Ahveninen J, Jääskeläinen IP, Raij T, Bonmassar G, Devore S, Hämäläinen M, Levänen S, Lin FH, Sams M, Shinn-Cunningham BG, Witzel T, Belliveau JW. Task-modulated "what" and "where" pathways in human auditory cortex. Proc Natl Acad Sci U S A. 2006 Sep 26; 103(39):14608-13.
    View in: PubMed
  47. Lin FH, Witzel T, Ahlfors SP, Stufflebeam SM, Belliveau JW, Hämäläinen MS. Assessing and improving the spatial accuracy in MEG source localization by depth-weighted minimum-norm estimates. Neuroimage. 2006 May 15; 31(1):160-71.
    View in: PubMed
  48. Knake S, Halgren E, Shiraishi H, Hara K, Hamer HM, Grant PE, Carr VA, Foxe D, Camposano S, Busa E, Witzel T, Hämäläinen MS, Ahlfors SP, Bromfield EB, Black PM, Bourgeois BF, Cole AJ, Cosgrove GR, Dworetzky BA, Madsen JR, Larsson PG, Schomer DL, Thiele EA, Dale AM, Rosen BR, Stufflebeam SM. The value of multichannel MEG and EEG in the presurgical evaluation of 70 epilepsy patients. Epilepsy Res. 2006 Apr; 69(1):80-6.
    View in: PubMed
  49. Bar M, Kassam KS, Ghuman AS, Boshyan J, Schmid AM, Schmidt AM, Dale AM, Hämäläinen MS, Marinkovic K, Schacter DL, Rosen BR, Halgren E. Top-down facilitation of visual recognition. Proc Natl Acad Sci U S A. 2006 Jan 10; 103(2):449-54.
    View in: PubMed
  50. Long CJ, Purdon RL, Temereanca S, Desai NU, Hämäläinen M, Brown EN. Large scale Kalman filtering solutions to the electrophysiological source localization problem--a MEG case study. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:4532-5.
    View in: PubMed
  51. Lin FH, Belliveau JW, Dale AM, Hämäläinen MS. Distributed current estimates using cortical orientation constraints. Hum Brain Mapp. 2006 Jan; 27(1):1-13.
    View in: PubMed
  52. Seppä M, Hämäläinen M. Visualizing human brain surface from T1-weighted MR images using texture-mapped triangle meshes. Neuroimage. 2005 May 15; 26(1):1-12.
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  53. Auranen T, Nummenmaa A, Hämäläinen MS, Jääskeläinen IP, Lampinen J, Vehtari A, Sams M. Bayesian analysis of the neuromagnetic inverse problem with l(p)-norm priors. Neuroimage. 2005 Jul 1; 26(3):870-84.
    View in: PubMed
  54. Ciesielski KT, Hämäläinen MS, Lesnik PG, Geller DA, Ahlfors SP. Increased MEG activation in OCD reflects a compensatory mechanism specific to the phase of a visual working memory task. Neuroimage. 2005 Feb 15; 24(4):1180-91.
    View in: PubMed
  55. Lin FH, Witzel T, Hämäläinen MS, Dale AM, Belliveau JW, Stufflebeam SM. Spectral spatiotemporal imaging of cortical oscillations and interactions in the human brain. Neuroimage. 2004 Oct; 23(2):582-95.
    View in: PubMed
  56. Uutela K, Taulu S, Hämäläinen M. Detecting and correcting for head movements in neuromagnetic measurements. Neuroimage. 2001 Dec; 14(6):1424-31.
    View in: PubMed
  57. Nolte G, Hämäläinen MS. Partial signal space projection for artefact removal in MEG measurements: a theoretical analysis. Phys Med Biol. 2001 Nov; 46(11):2873-87.
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  58. Mäkelä JP, Kirveskari E, Seppä M, Hämäläinen M, Forss N, Avikainen S, Salonen O, Salenius S, Kovala T, Randell T, Jääskeläinen J, Hari R. Three-dimensional integration of brain anatomy and function to facilitate intraoperative navigation around the sensorimotor strip. Hum Brain Mapp. 2001 Mar; 12(3):180-92.
    View in: PubMed
  59. Gross J, Kujala J, Hamalainen M, Timmermann L, Schnitzler A, Salmelin R. Dynamic imaging of coherent sources: Studying neural interactions in the human brain. Proc Natl Acad Sci U S A. 2001 Jan 16; 98(2):694-9.
    View in: PubMed
  60. Uutela K, Hämäläinen M, Somersalo E. Visualization of magnetoencephalographic data using minimum current estimates. Neuroimage. 1999 Aug; 10(2):173-80.
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  61. Uutela K, Hämäläinen M, Salmelin R. Global optimization in the localization of neuromagnetic sources. IEEE Trans Biomed Eng. 1998 Jun; 45(6):716-23.
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  62. Lounasmaa OV, Hämäläinen M, Hari R, Salmelin R. Information processing in the human brain: magnetoencephalographic approach. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):8809-15.
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  63. Vasama JP, Mäkelä JP, Tissari SO, Hämäläinen MS. Effects of intensity variation on human auditory evoked magnetic fields. Acta Otolaryngol. 1995 Sep; 115(5):616-21.
    View in: PubMed
  64. Kujala T, Huotilainen M, Sinkkonen J, Ahonen AI, Alho K, Hämäläinen MS, Ilmoniemi RJ, Kajola M, Knuutila JE, Lavikainen J, et al. Visual cortex activation in blind humans during sound discrimination. Neurosci Lett. 1995 Jan 2; 183(1-2):143-6.
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  65. Hämäläinen MS. Functional localization based on measurements with a whole-head magnetometer system. Brain Topogr. 1995; 7(4):283-9.
    View in: PubMed
  66. Salmelin RH, Hämäläinen MS. Dipole modelling of MEG rhythms in time and frequency domains. Brain Topogr. 1995; 7(3):251-7.
    View in: PubMed
  67. Greitz T, Bohm C, Hellstrand E, Hämäläinen MS, Hari R, Ilmoniemi LJ, Seitz R, Lounasmaa OV. Use of a computerized brain atlas in magnetoencephalographic activation studies. Neuroreport. 1994 Jan 12; 5(4):449-52.
    View in: PubMed
  68. Hämäläinen MS, Ilmoniemi RJ. Interpreting magnetic fields of the brain: minimum norm estimates. Med Biol Eng Comput. 1994 Jan; 32(1):35-42.
    View in: PubMed
  69. Nenonen JT, Hämäläinen MS, Ilmoniemi RJ. Minimum-norm estimation in a boundary-element torso model. Med Biol Eng Comput. 1994 Jan; 32(1):43-8.
    View in: PubMed
  70. Ahonen AI, Hämäläinen MS, Ilmoniemi RJ, Kajola MJ, Knuutila JE, Simola JT, Vilkman VA. Sampling theory for neuromagnetic detector arrays. IEEE Trans Biomed Eng. 1993 Sep; 40(9):859-69.
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  71. Ahlfors SP, Ilmoniemi RJ, Hämäläinen MS. Estimates of visually evoked cortical currents. Electroencephalogr Clin Neurophysiol. 1992 Mar; 82(3):225-36.
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  72. Hämäläinen MS. Magnetoencephalography: a tool for functional brain imaging. Brain Topogr. 1992; 5(2):95-102.
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  73. Rif J, Hari R, Hämäläinen MS, Sams M. Auditory attention affects two different areas in the human supratemporal cortex. Electroencephalogr Clin Neurophysiol. 1991 Dec; 79(6):464-72.
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  74. Kajola M, Ahonen A, Hämäläinen MS, Knuutila J, Lounasmaa OV, Simola J, Vilkman V. Development of multichannel neuromagnetic instrumentation in Finland. Clin Phys Physiol Meas. 1991; 12 Suppl B:39-44.
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  75. Hämäläinen MS. Basic principles of magnetoencephalography. Acta Radiol Suppl. 1991; 377:58-62.
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  76. de Munck JC, Hämäläinen MS, Peters MJ. The use of the asymptotic expansion to speed up the computation of a series of spherical harmonics. Clin Phys Physiol Meas. 1991; 12 Suppl A:83-7.
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  77. Lu ST, Hämäläinen MS, Hari R, Ilmoniemi RJ, Lounasmaa OV, Sams M, Vilkman V. Seeing faces activates three separate areas outside the occipital visual cortex in man. Neuroscience. 1991; 43(2-3):287-90.
    View in: PubMed
  78. Hämäläinen MS, Sarvas J. Realistic conductivity geometry model of the human head for interpretation of neuromagnetic data. IEEE Trans Biomed Eng. 1989 Feb; 36(2):165-71.
    View in: PubMed
  79. Hämäläinen MS, Sarvas J. Feasibility of the homogeneous head model in the interpretation of neuromagnetic fields. Phys Med Biol. 1987 Jan; 32(1):91-7.
    View in: PubMed
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