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Denise L. Faustman, M.D., PH.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMass General Hospital-East
Immunobiolgy Labs
149 13th Street
Charlestown MA 02129
Phone617/726-4084
Fax617/726-4095

 Research 
 research resources
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BADERC Flow Cytometry Core (HMS) - Core services (7) and Instruments (3)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Okubo Y, Mera T, Wang L, Faustman DL. Homogeneous expansion of human T-regulatory cells via tumor necrosis factor receptor 2. Sci Rep. 2013; 3:3153.
    View in: PubMed
  2. Faustman DL. Why were we wrong for so long? The pancreas of type 1 diabetic patients commonly functions for decades. Diabetologia. 2014 Jan; 57(1):1-3.
    View in: PubMed
  3. Enger TB, Samad-Zadeh A, Bouchie MP, Skarstein K, Galtung HK, Mera T, Walker J, Menko AS, Varelas X, Faustman DL, Jensen JL, A Kukuruzinska M. The Hippo signaling pathway is required for salivary gland development and its dysregulation is associated with Sjogren's syndrome. Lab Invest. 2013 Nov; 93(11):1203-18.
    View in: PubMed
  4. Martinez-Gamboa L, Lesemann K, Kuckelkorn U, Scheffler S, Ghannam K, Hahne M, Gaber-Elsner T, Egerer K, Naumann L, Buttgereit F, Dörner T, Kloetzel PM, Burmester GR, Faustman DL, Feist E. Gene expression of catalytic proteasome subunits and resistance toward proteasome inhibition of B lymphocytes from patients with primary sjogren syndrome. J Rheumatol. 2013 May; 40(5):663-73.
    View in: PubMed
  5. Faustman DL. EBV infection and anti-CD3 treatment for Type 1 diabetes: bad cop, good cop? Expert Rev Clin Immunol. 2013 Feb; 9(2):95-7.
    View in: PubMed
  6. Faustman DL, Wang L, Okubo Y, Burger D, Ban L, Man G, Zheng H, Schoenfeld D, Pompei R, Avruch J, Nathan DM. Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes. PLoS One. 2012; 7(8):e41756.
    View in: PubMed
  7. Wang L, Lovejoy NF, Faustman DL. Persistence of prolonged C-peptide production in type 1 diabetes as measured with an ultrasensitive C-peptide assay. Diabetes Care. 2012 Mar; 35(3):465-70.
    View in: PubMed
  8. Burger DE, Wang L, Ban L, Okubo Y, Kühtreiber WM, Leichliter AK, Faustman DL. Novel automated blood separations validate whole cell biomarkers. PLoS One. 2011; 6(7):e22430.
    View in: PubMed
  9. Faustman DL, Davis M. Stem cells in the spleen: therapeutic potential for Sjogren's syndrome, type I diabetes, and other disorders. Int J Biochem Cell Biol. 2010 Oct; 42(10):1576-9.
    View in: PubMed
  10. Faustman D, Davis M. TNF receptor 2 pathway: drug target for autoimmune diseases. Nat Rev Drug Discov. 2010 Jun; 9(6):482-93.
    View in: PubMed
  11. Dieguez-Acuña F, Kodama S, Okubo Y, Paz AC, Gygi SP, Faustman DL. Proteomics identifies multipotent and low oncogenic risk stem cells of the spleen. Int J Biochem Cell Biol. 2010 Oct; 42(10):1651-60.
    View in: PubMed
  12. Morawietz L, Martinez-Gamboa L, Scheffler S, Hausdorf G, Dankof A, Kuckelkorn U, Doerner T, Egerer K, Burmester GR, Faustman DL, Feist E. Expression of proteasomal immunosubunit beta1i is dysregulated in inflammatory infiltrates of minor salivary glands in Sjogren's syndrome. J Rheumatol. 2009 Dec; 36(12):2694-703.
    View in: PubMed
  13. Faustman DL, Davis M. The primacy of CD8 T lymphocytes in type 1 diabetes and implications for therapies. J Mol Med (Berl). 2009 Dec; 87(12):1173-8.
    View in: PubMed
  14. Faustman DL. Immunotherapy on trial for new-onset type 1 diabetes. N Engl J Med. 2008 Oct 30; 359(18):1956-8.
    View in: PubMed
  15. Ban L, Zhang J, Wang L, Kuhtreiber W, Burger D, Faustman DL. Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism. Proc Natl Acad Sci U S A. 2008 Sep 9; 105(36):13644-9.
    View in: PubMed
  16. Lonyai A, Kodama S, Burger D, Faustman DL. Fetal Hox11 expression patterns predict defective target organs: a novel link between developmental biology and autoimmunity. Immunol Cell Biol. 2008 May-Jun; 86(4):301-9.
    View in: PubMed
  17. Lonyai A, Kodama S, Burger D, Davis M, Faustman DL. The promise of Hox11+ stem cells of the spleen for treating autoimmune diseases. Horm Metab Res. 2008 Feb; 40(2):137-46.
    View in: PubMed
  18. Dieguez-Acuna FJ, Gygi SP, Davis M, Faustman DL. Splenectomy: a new treatment option for ALL tumors expressing Hox-11 and a means to test the stem cell hypothesis of cancer in humans. Leukemia. 2007 Oct; 21(10):2192-4.
    View in: PubMed
  19. Faustman DL. Permanent reversal of diabetes in NOD mice. Science. 2007 Jul 13; 317(5835):196.
    View in: PubMed
  20. Faustman DL. Reversal of type 1 diabetes in mice. N Engl J Med. 2007 Jan 18; 356(3):311-2.
    View in: PubMed
  21. Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Khalili S, Faustman DL, Mezey E. Reversal of Sjogren's-like syndrome in non-obese diabetic mice. Ann Rheum Dis. 2007 Jun; 66(6):812-4.
    View in: PubMed
  22. Dale E, Davis M, Faustman DL. A role for transcription factor NF-kappaB in autoimmunity: possible interactions of genes, sex, and the immune response. Adv Physiol Educ. 2006 Dec; 30(4):152-8.
    View in: PubMed
  23. Faustman DL, Tran SD, Kodama S, Lodde BM, Szalayova I, Key S, Toth ZE, Mezey E. Comment on papers by Chong et al., Nishio et al., and Suri et al. on diabetes reversal in NOD mice. Science. 2006 Nov 24; 314(5803):1243; author reply 1243.
    View in: PubMed
  24. Faustman D. Search for cure moves forward despite controversy. Interview by Ho Spencer. Nephrol News Issues. 2006 Jun; 20(7):24, 26.
    View in: PubMed
  25. Faustman DL. Regenerative medicine: Stem cell research turns to the spleen. Discov Med. 2005 Oct; 5(29):447-9.
    View in: PubMed
  26. Kühtreiber WM, Kodama S, Burger DE, Dale EA, Faustman DL. Methods to characterize lymphoid apoptosis in a murine model of autoreactivity. J Immunol Methods. 2005 Nov 30; 306(1-2):137-50.
    View in: PubMed
  27. Kodama S, Davis M, Faustman DL. The therapeutic potential of tumor necrosis factor for autoimmune disease: a mechanistically based hypothesis. Cell Mol Life Sci. 2005 Aug; 62(16):1850-62.
    View in: PubMed
  28. Dieguez-Acuna FJ, Gerber SA, Kodama S, Elias JE, Beausoleil SA, Faustman D, Gygi SP. Characterization of mouse spleen cells by subtractive proteomics. Mol Cell Proteomics. 2005 Oct; 4(10):1459-70.
    View in: PubMed
  29. Kodama S, Davis M, Faustman DL. Regenerative medicine: a radical reappraisal of the spleen. Trends Mol Med. 2005 Jun; 11(6):271-6.
    View in: PubMed
  30. Kodama S, Davis M, Faustman DL. Diabetes and stem cell researchers turn to the lowly spleen. Sci Aging Knowledge Environ. 2005 Jan 19; 2005(3):pe2.
    View in: PubMed
  31. Abraham EJ, Kodama S, Lin JC, Ubeda M, Faustman DL, Habener JF. Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice. Am J Pathol. 2004 Mar; 164(3):817-30.
    View in: PubMed
  32. Kodama S, Faustman DL. Routes to regenerating islet cells: stem cells and other biological therapies for type 1 diabetes. Pediatr Diabetes. 2004; 5 Suppl 2:38-44.
    View in: PubMed
  33. Kühtreiber WM, Hayashi T, Dale EA, Faustman DL. Central role of defective apoptosis in autoimmunity. J Mol Endocrinol. 2003 Dec; 31(3):373-99.
    View in: PubMed
  34. Kodama S, Kühtreiber W, Fujimura S, Dale EA, Faustman DL. Islet regeneration during the reversal of autoimmune diabetes in NOD mice. Science. 2003 Nov 14; 302(5648):1223-7.
    View in: PubMed
  35. Hayashi T, Faustman DL. Role of defective apoptosis in type 1 diabetes and other autoimmune diseases. Recent Prog Horm Res. 2003; 58:131-53.
    View in: PubMed
  36. Penfornis A, Yan G, Shi L, Faustman DL. Polymorphisms of human TAP2 detected by denaturing gradient gel electrophoresis. Hum Immunol. 2003 Jan; 64(1):156-67.
    View in: PubMed
  37. Yan G, Shi L, Penfornis A, Faustman DL. Impaired processing and presentation by MHC class II proteins in human diabetic cells. J Immunol. 2003 Jan 1; 170(1):620-7.
    View in: PubMed
  38. Faustman DL, Pedersen RL, Kim SK, Lemischka IR, McKay RD. Cells for repair: breakout session summary. Ann N Y Acad Sci. 2002 Jun; 961:45-7.
    View in: PubMed
  39. Faustman DL. Reversal of established autoimmune diabetes by in situ beta-cell regeneration. Ann N Y Acad Sci. 2002 Jun; 961:40.
    View in: PubMed
  40. Penfornis A, Tuomilehto-Wolf E, Faustman DL, Hitman GA. Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes. Hum Immunol. 2002 Jan; 63(1):61-70.
    View in: PubMed
  41. Hayashi T, Faustman DL. Development of spontaneous uterine tumors in low molecular mass polypeptide-2 knockout mice. Cancer Res. 2002 Jan 1; 62(1):24-7.
    View in: PubMed
  42. Hayashi T, Faustman DL. Selected contribution: Association of gender-related LMP2 inactivation with autoimmune pathogenesis. J Appl Physiol. 2001 Dec; 91(6):2804-15.
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  43. Ryu S, Kodama S, Ryu K, Schoenfeld DA, Faustman DL. Reversal of established autoimmune diabetes by restoration of endogenous beta cell function. J Clin Invest. 2001 Jul; 108(1):63-72.
    View in: PubMed
  44. Hayashi T, Faustman DL. Implications of altered apoptosis in diabetes mellitus and autoimmune disease. Apoptosis. 2001 Feb-Apr; 6(1-2):31-45.
    View in: PubMed
  45. Hayashi T, Kodama S, Faustman DL. Reply to 'LMP2 expression and proteasome activity in NOD mice' Nat Med. 2000 Oct; 6(10):1065-6.
    View in: PubMed
  46. Hayashi T, Faustman D. The role of the proteasome in autoimmunity. Diabetes Metab Res Rev. 2000 Sep-Oct; 16(5):325-37.
    View in: PubMed
  47. Yan G, Schoenfeld D, Penney C, Hurxthal K, Taylor AE, Faustman D. Identification of premature ovarian failure patients with underlying autoimmunity. J Womens Health Gend Based Med. 2000 Apr; 9(3):275-87.
    View in: PubMed
  48. Hayashi T, Faustman D. Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis. J Biol Chem. 2000 Feb 18; 275(7):5238-47.
    View in: PubMed
  49. Hayashi T, Faustman D. A role for NF-kappaB and the proteasome in autoimmunity. Arch Immunol Ther Exp (Warsz). 2000; 48(5):353-65.
    View in: PubMed
  50. Hayashi T, Faustman D. Defective function of the proteasome in autoimmunity: involvement of impaired NF-kappaB activation. Diabetes Technol Ther. 2000; 2(3):415-28.
    View in: PubMed
  51. Faustman DL. Antibodies for transplantation. Methods Mol Med. 2000; 40:141-56.
    View in: PubMed
  52. Hayashi T, Faustman D. NOD mice are defective in proteasome production and activation of NF-kappaB. Mol Cell Biol. 1999 Dec; 19(12):8646-59.
    View in: PubMed
  53. Faustman D. On the periphery: Nature questions the role of women in science. J Womens Health Gend Based Med. 1999 Oct; 8(8):1009-10.
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  54. Yan G, Shi L, Faustman D. Novel splicing of the human MHC-encoded peptide transporter confers unique properties. J Immunol. 1999 Jan 15; 162(2):852-9.
    View in: PubMed
  55. Fu Y, Yan G, Shi L, Faustman D. Antigen processing and autoimmunity. Evaluation of mRNA abundance and function of HLA-linked genes. Ann N Y Acad Sci. 1998 Apr 15; 842:138-55.
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  56. Yan G, Shi L, Fu Y, Wang X, Schoenfeld D, Ma L, Penfornis A, Gebel H, Faustman DL. Screening of the TAP1 gene by denaturing gradient gel electrophoresis in insulin-dependent diabetes mellitus: detection and comparison of new polymorphisms between patients and controls. Tissue Antigens. 1997 Dec; 50(6):576-85.
    View in: PubMed
  57. Faustman DL. Gender is important: lessons in autoimmunity. J Womens Health. 1997 Oct; 6(5):521-2.
    View in: PubMed
  58. Yan G, Fu Y, Faustman DL. Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter. J Immunol. 1997 Sep 15; 159(6):3068-80.
    View in: PubMed
  59. Lernmark A, Eisenbarth G, Ducat L, Erlich HA, Faustman D, Maclaren NK, Ott J, Permutt MA, She JX, Todd J. Family cell lines available for research--an endangered resource? Am J Hum Genet. 1997 Sep; 61(3):778-9.
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  60. Tambur AR, Foster P, Mellins E, Cresswell P, Faustman D, Gebel HM. Ultraviolet B irradiation reduces the surface expression of conformationally correct class I and II histocompatibility antigens. Transplant Proc. 1997 Sep; 29(6):2689-91.
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  61. Ma L, Penfornis A, Wang X, Schoenfeld D, Tuomilehto-Wolf E, Metcalfe K, Hitman G, Faustman D. Evaluation of TAP1 polymorphisms with insulin dependent diabetes mellitus in Finnish diabetic patients. The Childhood Diabetes in Finland (DiMe) Study Group. Hum Immunol. 1997 Apr 1; 53(2):159-66.
    View in: PubMed
  62. Shi L, Yan G, Fu Y, Ma L, Penfornis A, Faustman D. Human TAP1 polymorphisms detected by denaturing gradient gel electrophoresis. Tissue Antigens. 1997 Apr; 49(4):421-6.
    View in: PubMed
  63. Pinies JA, Fu Y, Vazquez JA, Faustman D. New monoclonal antibody diagnostic reagents for type I diabetes: differential lymphocyte surface antigen expression related to disease. Diabetes. 1997 Mar; 46(3):363-71.
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  64. Huang R, Guo J, Li X, Faustman DL. Elimination of self-peptide major histocompatibility complex class I reactivity in NOD and beta 2-microglobulin-negative mice. Diabetes. 1995 Sep; 44(9):1114-20.
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  65. Wang F, Li X, Annis B, Faustman DL. Tap-1 and Tap-2 gene therapy selectively restores conformationally dependent HLA Class I expression in type I diabetic cells. Hum Gene Ther. 1995 Aug; 6(8):1005-17.
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  66. Li F, Linan MJ, Stein MC, Faustman DL. Reduced expression of peptide-loaded HLA class I molecules on multiple sclerosis lymphocytes. Ann Neurol. 1995 Aug; 38(2):147-54.
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  67. Faustman DL. Altered MHC class I expression: a role for transplantation and IDDM autoimmunity. Diabetes Metab Rev. 1995 Apr; 11(1):1-19.
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  68. Faustman D. Strategies for circumventing transplant rejection: modification of cells, tissues and organs. Trends Biotechnol. 1995 Mar; 13(3):100-5.
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  69. Vidal-Puig A, Faustman DL. Tolerance to peripheral tissue is transient and maintained by tissue-specific class I expression. Transplant Proc. 1994 Dec; 26(6):3314-6.
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  70. Li F, Guo J, Fu Y, Yan G, Faustman D. Abnormal class I assembly and peptide presentation in the nonobese diabetic mouse. Proc Natl Acad Sci U S A. 1994 Nov 8; 91(23):11128-32.
    View in: PubMed
  71. Faustman DL. Occult CD45 T cell developmental defect in type 1 diabetes. Diabete Metab. 1993 Sep-Oct; 19(5):446-57.
    View in: PubMed
  72. Li X, Golden J, Faustman DL. Faulty major histocompatibility complex class II I-E expression is associated with autoimmunity in diverse strains of mice. Autoantibodies, insulitis, and sialadenitis. Diabetes. 1993 Aug; 42(8):1166-72.
    View in: PubMed
  73. Fu Y, Nathan DM, Li F, Li X, Faustman DL. Defective major histocompatibility complex class I expression on lymphoid cells in autoimmunity. J Clin Invest. 1993 May; 91(5):2301-7.
    View in: PubMed
  74. Li X, Faustman D. Use of donor beta 2-microglobulin-deficient transgenic mouse liver cells for isografts, allografts, and xenografts. Transplantation. 1993 Apr; 55(4):940-6.
    View in: PubMed
  75. Hardiman O, Faustman D, Li X, Sklar RM, Brown RH. Expression of major histocompatibility complex antigens in cultures of clonally derived human myoblasts. Neurology. 1993 Mar; 43(3 Pt 1):604-8.
    View in: PubMed
  76. Faustman DL. MHC class I and autoimmune diabetes. Biomed Pharmacother. 1993; 47(1):3-10.
    View in: PubMed
  77. Faustman D. Mechanisms of autoimmunity in type I diabetes. J Clin Immunol. 1993 Jan; 13(1):1-7.
    View in: PubMed
  78. Faustman D. Faulty major histocompatibility complex class I function linked to autoimmune diabetes. Transplant Proc. 1992 Dec; 24(6):2874-6.
    View in: PubMed
  79. Faustman D, Coe C. Xenograft acceptance by masking donor antigens. Transplant Proc. 1992 Dec; 24(6):2854-5.
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  80. Faustman D, Li X, Lin HY, Huang R, Guo J. Response. Science. 1992 Jun 26; 256(5065):1830-1.
    View in: PubMed
  81. Lanza RP, Butler DH, Borland KM, Harvey JM, Faustman DL, Solomon BA, Muller TE, Rupp RG, Maki T, Monaco AP, et al. Successful xenotransplantation of a diffusion-based biohybrid artificial pancreas: a study using canine, bovine, and porcine islets. Transplant Proc. 1992 Apr; 24(2):669-71.
    View in: PubMed
  82. Faustman D, Li XP, Lin HY, Fu YE, Eisenbarth G, Avruch J, Guo J. Linkage of faulty major histocompatibility complex class I to autoimmune diabetes. Science. 1991 Dec 20; 254(5039):1756-61.
    View in: PubMed
  83. Lanza RP, Butler DH, Borland KM, Staruk JE, Faustman DL, Solomon BA, Muller TE, Rupp RG, Maki T, Monaco AP, et al. Xenotransplantation of canine, bovine, and porcine islets in diabetic rats without immunosuppression. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11100-4.
    View in: PubMed
  84. Faustman D, Coe C. Prevention of xenograft rejection by masking donor HLA class I antigens. Science. 1991 Jun 21; 252(5013):1700-2.
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  85. Faustman D, Schoenfeld D, Ziegler R. T-lymphocyte changes linked to autoantibodies. Association of insulin autoantibodies with CD4+CD45R+ lymphocyte subpopulation in prediabetic subjects. Diabetes. 1991 May; 40(5):590-7.
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  86. Faustman D, Eisenbarth G, Breitmeyer J. Analysis of T lymphocyte subsets in all stages of diabetes. J Autoimmun. 1990 Apr; 3 Suppl 1:111-6.
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  87. Faustman D, Eisenbarth G, Daley J, Breitmeyer J. Abnormal T-lymphocyte subsets in type I diabetes. Diabetes. 1989 Nov; 38(11):1462-8.
    View in: PubMed
  88. Breitmeyer JB, Faustman DL. Sheep erythrocyte rosetting induces multiple alterations in T lymphocyte function: inhibition of T cell receptor activity and stimulation of T11/CD2. Cell Immunol. 1989 Oct 1; 123(1):118-33.
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  89. Faustman DL, Hauptfeld V, Davie JM, Lacy PE. Prolonged survival of donor skin grafts on mice bearing established islet of Langerhans transplants. Transplantation. 1985 Aug; 40(2):216-8.
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  90. Rossini AA, Faustman D, Woda BA, Like AA, Szymanski I, Mordes JP. Lymphocyte transfusions prevent diabetes in the Bio-Breeding/Worcester rat. J Clin Invest. 1984 Jul; 74(1):39-46.
    View in: PubMed
  91. Faustman DL, Steinman RM, Gebel HM, Hauptfeld V, Davie JM, Lacy PE. Prevention of rejection of murine islet allografts by pretreatment with anti-dendritic cell antibody. Proc Natl Acad Sci U S A. 1984 Jun; 81(12):3864-8.
    View in: PubMed
  92. Faustman D, Kraus P, Lacy PE, Finke EH, Davie JM. Survival of heart allografts in nonimmunosuppressed murine recipients by pretreatment of the donor tissue with anti-Ia antibodies. Transplantation. 1982 Nov; 34(5):302-5.
    View in: PubMed
  93. Faustman D, Lacy PE, Davie JM. Transplantation without immunosuppression. Diabetes. 1982 Aug; 31 Suppl 4:11-6.
    View in: PubMed
  94. Faustman D, Lacy P, Davie J, Hauptfeld V. Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells. Science. 1982 Jul 9; 217(4555):157-8.
    View in: PubMed
  95. Faustman D, Hauptfeld V, Lacy P, Davie J. Demonstration of active tolerance in maintenance of established islet of Langerhans allografts. Proc Natl Acad Sci U S A. 1982 Jul; 79(13):4153-5.
    View in: PubMed
  96. Faustman D, Hauptfeld V, Lacy P, Davie J. Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants. Proc Natl Acad Sci U S A. 1981 Aug; 78(8):5156-9.
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  97. Faustman D, Hauptfeld V, Davie JM, Lacy PE, Shreffler DC. Murine pancreatic beta-cells express H-2K and H-2D but not Ia antigens. J Exp Med. 1980 Jun 1; 151(6):1563-8.
    View in: PubMed
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