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Spyros Artavanis-Tsakonas, PH.D.

TitleProfessor of Cell Biology
InstitutionHarvard Medical School
DepartmentCell Biology
AddressHarvard Medical School
Department of Cell Biology, LHRRB-410A
240 Longwood Ave
Boston MA 02115
Phone617/432-7048
Fax617/432-7050

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hori K, Sen A, Artavanis-Tsakonas S. Genetic circuitry modulating notch signals through endosomal trafficking. Methods Enzymol. 2014; 534:283-99.
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  2. Oh P, Lobry C, Gao J, Tikhonova A, Loizou E, Manent J, van Handel B, Ibrahim S, Greve J, Mikkola H, Artavanis-Tsakonas S, Aifantis I. In Vivo mapping of notch pathway activity in normal and stress hematopoiesis. Cell Stem Cell. 2013 Aug 1; 13(2):190-204.
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  3. Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas S. Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2371-80.
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  4. Hori K, Sen A, Artavanis-Tsakonas S. Notch signaling at a glance. J Cell Sci. 2013 May 15; 126(Pt 10):2135-40.
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  5. Fleming RJ, Hori K, Sen A, Filloramo GV, Langer JM, Obar RA, Artavanis-Tsakonas S, Maharaj-Best AC. An extracellular region of Serrate is essential for ligand-induced cis-inhibition of Notch signaling. Development. 2013 May; 140(9):2039-49.
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  6. Sale S, Lafkas D, Artavanis-Tsakonas S. Notch2 genetic fate mapping reveals two previously unrecognized mammary epithelial lineages. Nat Cell Biol. 2013 May; 15(5):451-60.
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  7. Guruharsha KG, Obar RA, Mintseris J, Aishwarya K, Krishnan RT, Vijayraghavan K, Artavanis-Tsakonas S. Drosophila Protein interaction Map (DPiM): A paradigm for metazoan protein complex interactions. Fly (Austin). 2012 Oct 1; 6(4):246-53.
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  8. Guruharsha KG, Kankel MW, Artavanis-Tsakonas S. The Notch signalling system: recent insights into the complexity of a conserved pathway. Nat Rev Genet. 2012 Sep; 13(9):654-66.
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  9. Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S. Regulation of ligand-independent Notch signal through intracellular trafficking. Commun Integr Biol. 2012 Jul 1; 5(4):374-6.
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  10. Pallavi SK, Ho DM, Hicks C, Miele L, Artavanis-Tsakonas S. Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. EMBO J. 2012 Jun 29; 31(13):2895-907.
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  11. Louvi A, Artavanis-Tsakonas S. Notch and disease: a growing field. Semin Cell Dev Biol. 2012 Jun; 23(4):473-80.
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  12. Hori K, Sen A, Kirchhausen T, Artavanis-Tsakonas S. Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol. 2011 Dec 12; 195(6):1005-15.
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  13. Guruharsha KG, Rual JF, Zhai B, Mintseris J, Vaidya P, Vaidya N, Beekman C, Wong C, Rhee DY, Cenaj O, McKillip E, Shah S, Stapleton M, Wan KH, Yu C, Parsa B, Carlson JW, Chen X, Kapadia B, VijayRaghavan K, Gygi SP, Celniker SE, Obar RA, Artavanis-Tsakonas S. A protein complex network of Drosophila melanogaster. Cell. 2011 Oct 28; 147(3):690-703.
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  14. Fre S, Hannezo E, Sale S, Huyghe M, Lafkas D, Kissel H, Louvi A, Greve J, Louvard D, Artavanis-Tsakonas S. Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLoS One. 2011; 6(10):e25785.
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  15. Arboleda-Velasquez JF, Manent J, Lee JH, Tikka S, Ospina C, Vanderburg CR, Frosch MP, Rodríguez-Falcón M, Villen J, Gygi S, Lopera F, Kalimo H, Moskowitz MA, Ayata C, Louvi A, Artavanis-Tsakonas S. Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):E128-35.
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  16. Sun Y, Klauzinska M, Lake RJ, Lee JM, Santopietro S, Raafat A, Salomon D, Callahan R, Artavanis-Tsakonas S. Trp53 regulates Notch 4 signaling through Mdm2. J Cell Sci. 2011 Apr 1; 124(Pt 7):1067-76.
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  17. Sen A, Yokokura T, Kankel MW, Dimlich DN, Manent J, Sanyal S, Artavanis-Tsakonas S. Modeling spinal muscular atrophy in Drosophila links Smn to FGF signaling. J Cell Biol. 2011 Feb 7; 192(3):481-95.
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  18. Dimitriadi M, Sleigh JN, Walker A, Chang HC, Sen A, Kalloo G, Harris J, Barsby T, Walsh MB, Satterlee JS, Li C, Van Vactor D, Artavanis-Tsakonas S, Hart AC. Conserved genes act as modifiers of invertebrate SMN loss of function defects. PLoS Genet. 2010 Oct; 6(10):e1001172.
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  19. Kelly DF, Lake RJ, Middelkoop TC, Fan HY, Artavanis-Tsakonas S, Walz T. Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy. PLoS One. 2010; 5(5):e10532.
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  20. Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS. Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5012-7.
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  21. Artavanis-Tsakonas S, Muskavitch MA. Notch: the past, the present, and the future. Curr Top Dev Biol. 2010; 92:1-29.
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  22. Lake RJ, Grimm LM, Veraksa A, Banos A, Artavanis-Tsakonas S. In vivo analysis of the Notch receptor S1 cleavage. PLoS One. 2009; 4(8):e6728.
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  23. Fre S, Pallavi SK, Huyghe M, Laé M, Janssen KP, Robine S, Artavanis-Tsakonas S, Louvard D. Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc Natl Acad Sci U S A. 2009 Apr 14; 106(15):6309-14.
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  24. Hurlbut GD, Kankel MW, Artavanis-Tsakonas S. Nodal points and complexity of Notch-Ras signal integration. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2218-23.
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  25. Chang HC, Dimlich DN, Yokokura T, Mukherjee A, Kankel MW, Sen A, Sridhar V, Fulga TA, Hart AC, Van Vactor D, Artavanis-Tsakonas S. Modeling spinal muscular atrophy in Drosophila. PLoS One. 2008; 3(9):e3209.
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  26. Arboleda-Velasquez JF, Zhou Z, Shin HK, Louvi A, Kim HH, Savitz SI, Liao JK, Salomone S, Ayata C, Moskowitz MA, Artavanis-Tsakonas S. Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4856-61.
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  27. Bentley AM, Artavanis-Tsakonas S, Stanford JS. Nanocourses: a short course format as an educational tool in a biological sciences graduate curriculum. CBE Life Sci Educ. 2008; 7(2):175-83.
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  28. Kankel MW, Hurlbut GD, Upadhyay G, Yajnik V, Yedvobnick B, Artavanis-Tsakonas S. Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector. Genetics. 2007 Dec; 177(4):2493-505.
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  29. Kelly DF, Lake RJ, Walz T, Artavanis-Tsakonas S. Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless. Proc Natl Acad Sci U S A. 2007 Jun 5; 104(23):9591-6.
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  30. Hurlbut GD, Kankel MW, Lake RJ, Artavanis-Tsakonas S. Crossing paths with Notch in the hyper-network. Curr Opin Cell Biol. 2007 Apr; 19(2):166-75.
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  31. Klinakis A, Szabolcs M, Politi K, Kiaris H, Artavanis-Tsakonas S, Efstratiadis A. Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9262-7.
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  32. Louvi A, Artavanis-Tsakonas S. Notch signalling in vertebrate neural development. Nat Rev Neurosci. 2006 Feb; 7(2):93-102.
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  33. Mourikis P, Hurlbut GD, Artavanis-Tsakonas S. Enigma, a mitochondrial protein affecting lifespan and oxidative stress response in Drosophila. Proc Natl Acad Sci U S A. 2006 Jan 31; 103(5):1307-12.
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  34. Louvi A, Arboleda-Velasquez JF, Artavanis-Tsakonas S. CADASIL: a critical look at a Notch disease. Dev Neurosci. 2006; 28(1-2):5-12.
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  35. Mukherjee A, Veraksa A, Bauer A, Rosse C, Camonis J, Artavanis-Tsakonas S. Regulation of Notch signalling by non-visual beta-arrestin. Nat Cell Biol. 2005 Dec; 7(12):1191-201.
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  36. Robine S, Fre S, Huyghe M, Artavanis-Tsakonas S, Louvard D. [Notch signals control the fate of immature progenitor cells in the intestine]. Med Sci (Paris). 2005 Aug-Sep; 21(8-9):780-2.
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  37. Fre S, Huyghe M, Mourikis P, Robine S, Louvard D, Artavanis-Tsakonas S. Notch signals control the fate of immature progenitor cells in the intestine. Nature. 2005 Jun 16; 435(7044):964-8.
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  38. Veraksa A, Bauer A, Artavanis-Tsakonas S. Analyzing protein complexes in Drosophila with tandem affinity purification-mass spectrometry. Dev Dyn. 2005 Mar; 232(3):827-34.
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  39. Kiaris H, Politi K, Grimm LM, Szabolcs M, Fisher P, Efstratiadis A, Artavanis-Tsakonas S. Modulation of notch signaling elicits signature tumors and inhibits hras1-induced oncogenesis in the mouse mammary epithelium. Am J Pathol. 2004 Aug; 165(2):695-705.
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  40. Moberg KH, Mukherjee A, Veraksa A, Artavanis-Tsakonas S, Hariharan IK. The Drosophila F box protein archipelago regulates dMyc protein levels in vivo. Curr Biol. 2004 Jun 8; 14(11):965-74.
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  41. Artavanis-Tsakonas S. Accessing the Exelixis collection. Nat Genet. 2004 Mar; 36(3):207.
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  42. Grandbarbe L, Bouissac J, Rand M, Hrabé de Angelis M, Artavanis-Tsakonas S, Mohier E. Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process. Development. 2003 Apr; 130(7):1391-402.
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  43. Beltran S, Blanco E, Serras F, Pérez-Villamil B, Guigó R, Artavanis-Tsakonas S, Corominas M. Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3293-8.
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  44. Kiaris, H., Grimm, L., Politi, K., Fisher, P., Efstratiadis, A., and Artavanis-Tsakonas, S.,. Modulation of Notch signals elicit signature tumors and inhibit ras induced oncogenesis in the mouse mammary epithelium. (Submitted). 2003.
  45. Grandbarbe, L., Bouissac, J., Rand, M., Hrabe de Angelis, M., Artavanis-Tsakonas, S., and Mohier, E., . Delta-Notch signaling controls the generation of neurons/glia from neural stem cells in a stepwise process. Development . 2003; 130:1391-1402.
  46. Grimm, L., Veraksa, A., Baur, A., Artavanis-Tsakonas, S.,. S1 Cleavage of the Notch Receptor: A Functional Analysis. (Submitted). 2003.
  47. Moberg, H. K., Mukherjee, A., Veraksa, A., Artavanis-Tsakonas, S., Hariharan, I., . The Drosophila F-box protein Archipelago regulates dMYC protein levels in vivo. (Submitted). 2003.
  48. Mishra-Gorur K, Rand MD, Perez-Villamil B, Artavanis-Tsakonas S. Down-regulation of Delta by proteolytic processing. J Cell Biol. 2002 Oct 28; 159(2):313-24.
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  49. Artavanis-Tsakonas et al. Activated Forms of Notch and Methods Based Thereon. 2002.
  50. Matsuno K, Ito M, Hori K, Miyashita F, Suzuki S, Kishi N, Artavanis-Tsakonas S, Okano H. Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling. Development. 2002 Feb; 129(4):1049-59.
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  51. Kiaris H, Schally AV, Busto R, Halmos G, Artavanis-Tsakonas S, Varga JL. Expression of a splice variant of the receptor for GHRH in 3T3 fibroblasts activates cell proliferation responses to GHRH analogs. Proc Natl Acad Sci U S A. 2002 Jan 8; 99(1):196-200.
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  52. Artavanis-Tsakonas et al. Nucleotide and Protein Sequences of the Vertebrate Delta Genes and Methods Based Thereon. 2001.
  53. Kishi N, Tang Z, Maeda Y, Hirai A, Mo R, Ito M, Suzuki S, Nakao K, Kinoshita T, Kadesch T, Hui C, Artavanis-Tsakonas S, Okano H, Matsuno K. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Int J Dev Neurosci. 2001 Feb; 19(1):21-35.
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  54. Artavanis-Tsakonas et al. Manipulation of Tissue or Organ Type Using the Notch Pathway. 2001.
  55. Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet. 2000 Dec; 26(4):484-9.
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  56. Artavanis-Tsakonas et al. . Manipulation of Non-Terminally Differentiated Cells Using the Notch Pathway. 2000.
  57. Artavanis-Tsakonas et al. Antibodies to Human Notch Proteins and Fragments. 2000.
  58. Artavanis-Tsakonas et al. Therapeutic and Diagnostic Methods and Compositions Based on Notch Proteins and Nucleic Acids. 2000.
  59. Rand MD, Grimm LM, Artavanis-Tsakonas S, Patriub V, Blacklow SC, Sklar J, Aster JC. Calcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol. 2000 Mar; 20(5):1825-35.
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  60. Kurata S, Go MJ, Artavanis-Tsakonas S, Gehring WJ. Notch signaling and the determination of appendage identity. Proc Natl Acad Sci U S A. 2000 Feb 29; 97(5):2117-22.
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  61. Artavanis-Tsakonas et al. Delta Cleavage Products and Methods Based Thereon. 2000.
  62. Artavanis-Tsakonas et al. Delta Cleavage Products and Methods Based Thereon. 2000.
  63. Artavanis-Tsakonas et al. Nucleotide and Protein Sequences of the Vertebrate Serrate Gene and Methods Based Thereon. 1999.
  64. Sestan N, Artavanis-Tsakonas S, Rakic P. Contact-dependent inhibition of cortical neurite growth mediated by notch signaling. Science. 1999 Oct 22; 286(5440):741-6.
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  65. Hing HK, Bangalore L, Sun X, Artavanis-Tsakonas S. Mutations in the heatshock cognate 70 protein (hsc4) modulate Notch signaling. Eur J Cell Biol. 1999 Oct; 78(10):690-7.
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  66. Purcell K, Artavanis-Tsakonas S. The developmental role of warthog, the notch modifier encoding Drab6. J Cell Biol. 1999 Aug 23; 146(4):731-40.
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  67. Cornell M, Evans DA, Mann R, Fostier M, Flasza M, Monthatong M, Artavanis-Tsakonas S, Baron M. The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase. Genetics. 1999 Jun; 152(2):567-76.
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  68. Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate control and signal integration in development. Science. 1999 Apr 30; 284(5415):770-6.
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  69. Gray GE, Mann RS, Mitsiadis E, Henrique D, Carcangiu ML, Banks A, Leiman J, Ward D, Ish-Horowitz D, Artavanis-Tsakonas S. Human ligands of the Notch receptor. Am J Pathol. 1999 Mar; 154(3):785-94.
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  70. Artavanis-Tsakonas et al. Nucleotide and Protein Sequences of the Serrate Gene and Methods Based Thereon. 1999.
  71. Artavanis-Tsakonas et al. Activated Forms of Notch and Methods Based Thereon. 1999.
  72. Artavanis-Tsakonas . Serrate Fragments and Derivatives. 1999.
  73. Qi H, Rand MD, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-Tsakonas S. Processing of the notch ligand delta by the metalloprotease Kuzbanian. Science. 1999 Jan 1; 283(5398):91-4.
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  74. Artavanis-Tsakonas. Delta Fragments and Derivatives and Methods Based Thereon. 1998.
  75. Fostier M, Evans DA, Artavanis-Tsakonas S, Baron M. Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: A regulator of notch signaling. Genetics. 1998 Dec; 150(4):1477-85.
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  76. Go MJ, Artavanis-Tsakonas S. A genetic screen for novel components of the notch signaling pathway during Drosophila bristle development. Genetics. 1998 Sep; 150(1):211-20.
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  77. Artavanis-Tsakonas et al. Human Notch and Delta, Binding Domains in Toporythmic Proteins, and Methods Based Thereon. 1998.
  78. Artavanis-Tsakonas et al. Therapeutic and Diagnostic Methods and Compositions Based on Notch Proteins and Nucleic Acids. 1998.
  79. Artavanis-Tsakonas et al. Manipulation of Non-Terminally Differentiated Cells Using the Notch Pathway. 1998.
  80. Varnum-Finney B, Purton LE, Yu M, Brashem-Stein C, Flowers D, Staats S, Moore KA, Le Roux I, Mann R, Gray G, Artavanis-Tsakonas S, Bernstein ID. The Notch ligand, Jagged-1, influences the development of primitive hematopoietic precursor cells. Blood. 1998 Jun 1; 91(11):4084-91.
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  81. Go MJ, Eastman DS, Artavanis-Tsakonas S. Cell proliferation control by Notch signaling in Drosophila development. Development. 1998 Jun; 125(11):2031-40.
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  82. Artavanis-Tsakonas et al. . Deltex Proteins. 1998.
  83. Matsuno K, Eastman D, Mitsiades T, Quinn AM, Carcanciu ML, Ordentlich P, Kadesch T, Artavanis-Tsakonas S. Human deltex is a conserved regulator of Notch signalling. Nat Genet. 1998 May; 19(1):74-8.
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  84. Ordentlich P, Lin A, Shen CP, Blaumueller C, Matsuno K, Artavanis-Tsakonas S, Kadesch T. Notch inhibition of E47 supports the existence of a novel signaling pathway. Mol Cell Biol. 1998 Apr; 18(4):2230-9.
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  85. Matsuno K, Go MJ, Sun X, Eastman DS, Artavanis-Tsakonas S. Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements. Development. 1997 Nov; 124(21):4265-73.
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  86. Fleming RJ, Purcell K, Artavanis-Tsakonas S. The NOTCH receptor and its ligands. Trends Cell Biol. 1997 Nov; 7(11):437-41.
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  87. Capobianco AJ, Zagouras P, Blaumueller CM, Artavanis-Tsakonas S, Bishop JM. Neoplastic transformation by truncated alleles of human NOTCH1/TAN1 and NOTCH2. Mol Cell Biol. 1997 Nov; 17(11):6265-73.
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  88. Sun X, Artavanis-Tsakonas S. Secreted forms of DELTA and SERRATE define antagonists of Notch signaling in Drosophila. Development. 1997 Sep; 124(17):3439-48.
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  89. Frankel S, Sigel EA, Craig C, Elgin SC, Mooseker MS, Artavanis-Tsakonas S. An actin-related protein in Drosophila colocalizes with heterochromatin protein 1 in pericentric heterochromatin. J Cell Sci. 1997 Sep; 110 ( Pt 17):1999-2012.
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  90. Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S. Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane. Cell. 1997 Jul 25; 90(2):281-91.
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  91. Artavanis-Tsakonas et al. Human Notch and Delta, Binding Domains in Toporythmic Proteins, and Methods Based Thereon. 1997.
  92. Artavanis-Tsakonas S. Alagille syndrome--a notch up for the Notch receptor. Nat Genet. 1997 Jul; 16(3):212-3.
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  93. Artavanis-Tsakonas et al. Therapeutic and Diagnostic Methods and Compositions Based on Transducin-Like Enhancer of Split Proteins and Nucleic Acids. 1997.
  94. Artavanis-Tsakonas et al. Vertebrate Deltex Proteins, Nucleic Acids and Antibodies, and Related Methods and Compositions. 1997.
  95. Artavanis-Tsakonas et al. Manipulation of Non-Terminally Differentiated Cells Using the Notch Pathway. 1997.
  96. Artavanis-Tsakonas et al. Nucleotide and Protein Sequences on the Vertebrate Delta Genes and Methods Based Thereon. 1997.
  97. Artavanis-Tsakonas, S.,. Human Alagille Syndrome- a notch up for the Notch Receptor. Nat Gent. 1997; 16:212-13.
  98. Blaumueller CM, Artavanis-Tsakonas S. Comparative aspects of Notch signaling in lower and higher eukaryotes. Perspect Dev Neurobiol. 1997; 4(4):325-43.
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  99. Verheyen EM, Purcell KJ, Fortini ME, Artavanis-Tsakonas S. Analysis of dominant enhancers and suppressors of activated Notch in Drosophila. Genetics. 1996 Nov; 144(3):1127-41.
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  100. Ish-Horowicz et al. Nucleotide and Protein Sequences on the Vertebrate Serrate Gene and Methods Based Thereon. 1996.
  101. Sun X, Artavanis-Tsakonas S. The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands. Development. 1996 Aug; 122(8):2465-74.
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  102. Axelrod JD, Matsuno K, Artavanis-Tsakonas S, Perrimon N. Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Science. 1996 Mar 29; 271(5257):1826-32.
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  103. Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S. Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. Genomics. 1996 Jan 1; 31(1):58-64.
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  104. Ahmad I, Zaqouras P, Artavanis-Tsakonas S. Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells. Mech Dev. 1995 Sep; 53(1):73-85.
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  105. Matsuno K, Diederich RJ, Go MJ, Blaumueller CM, Artavanis-Tsakonas S. Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats. Development. 1995 Aug; 121(8):2633-44.
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  106. Zagouras P, Stifani S, Blaumueller CM, Carcangiu ML, Artavanis-Tsakonas S. Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc Natl Acad Sci U S A. 1995 Jul 3; 92(14):6414-8.
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  107. Dawson IA, Roth S, Artavanis-Tsakonas S. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. J Cell Biol. 1995 May; 129(3):725-37.
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  108. Artavanis-Tsakonas S, Matsuno K, Fortini ME. Notch signaling. Science. 1995 Apr 14; 268(5208):225-32.
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  109. Matsuno, K., Diederich, R.J., Go, M.J., Blaumueller, C.M., and Artavanis-Tsakonas, S., . The Involvement of Deltex in Notch Signaling. Development. 1995; 121:2633-44.
  110. Matsuno, K., Diederich, R.J., Go, M.J., Blaumueller, C.M., and Artavanis-Tsakonas, S., . The Involvement of Deltex in Notch Signaling. Development. 1995; 121:2633-44.
  111. Fortini ME, Artavanis-Tsakonas S. The suppressor of hairless protein participates in notch receptor signaling. Cell. 1994 Oct 21; 79(2):273-82.
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  112. Hing HK, Sun X, Artavanis-Tsakonas S. Modulation of wingless signaling by Notch in Drosophila. Mech Dev. 1994 Sep; 47(3):261-8.
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  113. Morgan NS, Skovronsky DM, Artavanis-Tsakonas S, Mooseker MS. The molecular cloning and characterization of Drosophila melanogaster myosin-IA and myosin-IB. J Mol Biol. 1994 Jun 10; 239(3):347-56.
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  114. Artavanis-Tsakonas et al. Therapeutic and Diagnostic Methods and Compositions Based on Notch Proteins and Nucleic Acids. 1994.
  115. Diederich RJ, Matsuno K, Hing H, Artavanis-Tsakonas S. Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. Development. 1994 Mar; 120(3):473-81.
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  116. Fehon RG, Dawson IA, Artavanis-Tsakonas S. A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development. 1994 Mar; 120(3):545-57.
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  117. Busseau I, Diederich RJ, Xu T, Artavanis-Tsakonas S. A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein. Genetics. 1994 Feb; 136(2):585-96.
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  118. Frankel S, Heintzelman MB, Artavanis-Tsakonas S, Mooseker MS. Identification of a divergent actin-related protein in Drosophila. J Mol Biol. 1994 Jan 28; 235(4):1351-6.
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  119. Fortini ME, Artavanis-Tsakonas S. Notch: neurogenesis is only part of the picture. Cell. 1993 Dec 31; 75(7):1245-7.
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  120. Fortini ME, Rebay I, Caron LA, Artavanis-Tsakonas S. An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature. 1993 Oct 7; 365(6446):555-7.
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  121. Rebay I, Fortini ME, Artavanis-Tsakonas S. Analysis of phenotypic abnormalities and cell fate changes caused by dominant activated and dominant negative forms of the Notch receptor in Drosophila development. C R Acad Sci III. 1993 Sep; 316(9):1097-123.
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  122. Rebay I, Fehon RG, Artavanis-Tsakonas S. Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor. Cell. 1993 Jul 30; 74(2):319-29.
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  123. Fleming and Artavanis-Tsakonas. Nucleotide and Protein Sequences on the Serrate Gene and Methods Based Thereon. 1993.
  124. Heintzelman MB, Frankel SA, Artavanis-Tsakonas S, Mooseker MS. Cloning of a secretory gelsolin from Drosophila melanogaster. J Mol Biol. 1993 Apr 5; 230(3):709-16.
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  125. Dawson IA, Roth S, Akam M, Artavanis-Tsakonas S. Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos. Development. 1993 Jan; 117(1):359-76.
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  126. Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S. Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nat Genet. 1992 Dec; 2(4):343.
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  127. Artavanis-Tsakonas et al. Human Notch and Delta, Binding Domains in Toporythmic Proteins, and Methods Based Thereon. 1992.
  128. Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S. Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. Nat Genet. 1992 Oct; 2(2):119-27.
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  129. Rothberg JM, Artavanis-Tsakonas S. Modularity of the slit protein. Characterization of a conserved carboxy-terminal sequence in secreted proteins and a motif implicated in extracellular protein interactions. J Mol Biol. 1992 Sep 20; 227(2):367-70.
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  130. Delidakis C, Artavanis-Tsakonas S. The Enhancer of split [E(spl)] locus of Drosophila encodes seven independent helix-loop-helix proteins. Proc Natl Acad Sci U S A. 1992 Sep 15; 89(18):8731-5.
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  131. Xu T, Caron LA, Fehon RG, Artavanis-Tsakonas S. The involvement of the Notch locus in Drosophila oogenesis. Development. 1992 Aug; 115(4):913-22.
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  132. Delidakis, C., and Artavanis-Tsakonas, S., . The Enhancer of split locus of Drosophila harbors seven independent HLH proteins. Proc Natl Acad Sci U S A. 1992; 89:8731-5.
  133. Rebay I, Fleming RJ, Fehon RG, Cherbas L, Cherbas P, Artavanis-Tsakonas S. Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor. Cell. 1991 Nov 15; 67(4):687-99.
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  134. Delidakis C, Preiss A, Hartley DA, Artavanis-Tsakonas S. Two genetically and molecularly distinct functions involved in early neurogenesis reside within the Enhancer of split locus of Drosophila melanogaster. Genetics. 1991 Nov; 129(3):803-23.
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  135. Artavanis-Tsakonas S, Simpson P. Choosing a cell fate: a view from the Notch locus. Trends Genet. 1991 Nov-Dec; 7(11-12):403-8.
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  136. Fehon RG, Johansen K, Rebay I, Artavanis-Tsakonas S. Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function. J Cell Biol. 1991 May; 113(3):657-69.
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  137. Markopoulou K, Artavanis-Tsakonas S. Developmental analysis of the facets, a group of intronic mutations at the Notch locus of Drosophila melanogaster that affect postembryonic development. J Exp Zool. 1991 Mar; 257(3):314-29.
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  138. Artavanis-Tsakonas S, Delidakis C, Fehon RG. The Notch locus and the cell biology of neuroblast segregation. Annu Rev Cell Biol. 1991; 7:427-52.
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  139. Rothberg JM, Jacobs JR, Goodman CS, Artavanis-Tsakonas S. slit: an extracellular protein necessary for development of midline glia and commissural axon pathways contains both EGF and LRR domains. Genes Dev. 1990 Dec; 4(12A):2169-87.
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  140. Fleming RJ, Scottgale TN, Diederich RJ, Artavanis-Tsakonas S. The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev. 1990 Dec; 4(12A):2188-201.
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  141. Xu T, Artavanis-Tsakonas S. deltex, a locus interacting with the neurogenic genes, Notch, Delta and mastermind in Drosophila melanogaster. Genetics. 1990 Nov; 126(3):665-77.
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  142. Artavanis-Tsakonas S, Delidakis C, Fehon R, Hartley D, Herndon V, Johansen K, Markopoulou K, Preiss A, Rebay I, Scottgale N, et al. Notch and the molecular genetics of neuroblast segregation in Drosophila. Mol Reprod Dev. 1990 Sep; 27(1):23-7.
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  143. Fehon RG, Kooh PJ, Rebay I, Regan CL, Xu T, Muskavitch MA, Artavanis-Tsakonas S. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell. 1990 May 4; 61(3):523-34.
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  144. Xu T, Rebay I, Fleming RJ, Scottgale TN, Artavanis-Tsakonas S. The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis. Genes Dev. 1990 Mar; 4(3):464-75.
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  145. Markopoulou, K., and Artavanis-Tsakonas, S., . Genetic and developmental analysis of the facet alleles in the Notch locus. Journal of Experimental Zoology. 1990; 27:23-27.
  146. Fleming, R.J., Scottgale, T.N., Diederich, R.J., and Artavanis-Tsakonas, S., . The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev. 4: 2188-201. 1990; 4:2188-201.
  147. Johansen KM, Fehon RG, Artavanis-Tsakonas S. The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development. J Cell Biol. 1989 Nov; 109(5):2427-40.
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  148. Ramos RG, Grimwade BG, Wharton KA, Scottgale TN, Artavanis-Tsakonas S. Physical and functional definition of the Drosophila Notch locus by P element transformation. Genetics. 1989 Oct; 123(2):337-48.
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  149. Markopoulou K, Artavanis-Tsakonas S. The expression of the neurogenic locus Notch during the postembryonic development of Drosophila melanogaster and its relationship to mitotic activity. J Neurogenet. 1989 Sep; 6(1):11-26.
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  150. Markopoulou K, Welshons WJ, Artavanis-Tsakonas S. Phenotypic and molecular analysis of the facets, a group of intronic mutations at the Notch locus of Drosophila melanogaster which affect postembryonic development. Genetics. 1989 Jun; 122(2):417-28.
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  151. Markopoulou, K., Welshons, W.J., and Artavanis-Tsakonas, S., . Phenotypic and molecular analysis of the facets, a group of intronic mutations in the Notch locus. Genetics. 1989; 122:417-28.
  152. Rothberg JM, Hartley DA, Walther Z, Artavanis-Tsakonas S. slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system. Cell. 1988 Dec 23; 55(6):1047-59.
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  153. Hartley DA, Preiss A, Artavanis-Tsakonas S. A deduced gene product from the Drosophila neurogenic locus, enhancer of split, shows homology to mammalian G-protein beta subunit. Cell. 1988 Dec 2; 55(5):785-95.
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  154. Preiss A, Hartley DA, Artavanis-Tsakonas S. The molecular genetics of Enhancer of split, a gene required for embryonic neural development in Drosophila. EMBO J. 1988 Dec 1; 7(12):3917-27.
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  155. Artavanis-Tsakonas S. The molecular biology of the Notch locus and the fine tuning of differentiation in Drosophila. Trends Genet. 1988 Apr; 4(4):95-100.
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  156. Hartley DA, Xu TA, Artavanis-Tsakonas S. The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF-like domain of the predicted protein. EMBO J. 1987 Nov; 6(11):3407-17.
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  157. Artavanis-Tsakonas, S., Grimwade, B., Halpern, M., Johansen, K., Markopoulou, K., Ramos, C., Schleschinger-Bryant, R., Wharton, K., and Yedvobnick, B., . Molecular biology of genes involved in the neurogenesis of Drosophila. Proc. 44th Symp. of the Society for Developmental Biology. 1986.
  158. Wharton KA, Johansen KM, Xu T, Artavanis-Tsakonas S. Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell. 1985 Dec; 43(3 Pt 2):567-81.
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  159. Grimwade BG, Muskavitch MA, Welshons WJ, Yedvobnick B, Artavanis-Tsakonas S. The molecular genetics of the Notch locus in Drosophila melanogaster. Dev Biol. 1985 Feb; 107(2):503-19.
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  160. Wharton KA, Yedvobnick B, Finnerty VG, Artavanis-Tsakonas S. opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster. Cell. 1985 Jan; 40(1):55-62.
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  161. Yedvobnick B, Muskavitch MA, Wharton KA, Halpern ME, Paul E, Grimwade BG, Artavanis-Tsakonas S. Molecular genetics of Drosophila neurogenesis. Cold Spring Harb Symp Quant Biol. 1985; 50:841-54.
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  162. Artavanis-Tsakonas, S., Grimwade, B., Harrison, B., Markopoulou, K., Muskavitch, M., Schlesinger-Bryant, R., Wharton, K., and Yedvobnick, B., . The Notch locus of Drosophila melanogaster: A molecular analysis. Developmental Genetics. 1984; 4:223-254.
  163. Artavanis-Tsakonas S, Muskavitch MA, Yedvobnick B. Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1983 Apr; 80(7):1977-81.
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  164. Artavanis-Tsakonas, S., Muskavitch, M., and Yedvobnick, B.,. The molecular cloning of Notch: a locus affecting neurogenesis in Drosophila. Proc Natl Acad Sci U S A. 1983; 80:1977-81.
  165. Lis J, Neckameyer W, Mirault ME, Artavanis-Tsakonas S, Lall P, Martin G, Schedl P. DNA sequences flanking the starts of the hsp 70 and alpha beta heat shock genes are homologous. Dev Biol. 1981 Apr 30; 83(2):291-300.
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  166. Dudler R, Egg AH, Kubli E, Artavanis-Tsakonas S, Gehring WJ, Steward R, Schedl P. Transfer RNA genes of Drosophila melanogaster. Nucleic Acids Res. 1980 Jul 11; 8(13):2921-37.
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  167. Artavanis-Tsakonas S, Harris JI. Primary structure of triosephosphate isomerase from Bacillus stearothermophilus. Eur J Biochem. 1980 Jul; 108(2):599-611.
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  168. Ish-Horowicz D, Pinchin SM, Schedl P, Artavanis-Tsakonas S, Mirault ME. Genetic and molecular analysis of the 87A7 and 87C1 heat-inducible loci of D. melanogaster. Cell. 1979 Dec; 18(4):1351-8.
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  169. Mirault ME, Goldschmidt-Clermont M, Artavanis-Tsakonas S, Schedl P. Organization of the multiple genes for the 70,000-dalton heat-shock protein in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):5254-8.
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  170. Artavanis-Tsakonas S, Schedl P, Mirault ME, Moran L, Lis J. Genes for the 70,000 dalton heat shock protein in two cloned D. melanogaster DNA segments. Cell. 1979 May; 17(1):9-18.
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  171. Moran L, Mirault ME, Tissières A, Lis J, Schedl P, Artavanis-Tsakonas S, Gehring WJ. Physical map of two D. melanogaster DNA segments containing sequences coding for the 70,000 dalton heat shock protein. Cell. 1979 May; 17(1):1-8.
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  172. Schedl P, Artavanis-Tsakonas S, Steward R, Gehring WJ, Mirault ME, Goldschmidt-Clermont M, Moran L, Tissières A. Two hybrid plasmids with D. melanogaster DNA sequences complementary to mRNA coding for the major heat shock protein. Cell. 1978 Aug; 14(4):921-9.
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  173. Weideli H, Schedl P, Artavanis-Tsakonas S, Steward R, Yuan R, Gehring WJ. Purification of a protein from unfertilized eggs of Drosophila with specific affinity for a defined DNA sequence and the cloning of this DNA sequence in bacterial plasmids. Cold Spring Harb Symp Quant Biol. 1978; 42 Pt 2:693-700.
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  174. Artavanis-Tsakonas, S., Tissieres, A., Moran, L., Mirault, M.E., Goldschmidt-Clermont, M., Arrigo, P., Schedl, P., Steward, R., Gehring, W.J., and Lis, J.,. Heat activated genes of Drosophila melanogaster. Alfred Benzon Symposium 13 on Specific Eucaryotic Genes. 1978; 82.
  175. Artavanis-Tsakonas S, Schedl P, Tschudi C, Pirrotta V, Steward R, Gehring WJ. The 5S genes of Drosophila melanogaster. Cell. 1977 Dec; 12(4):1057-67.
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  176. Artavanis-Tsakonas, S. Triose phosphate isomerase from Bacillus stearothermophilus. 1975.
  177. Artavanis-Tsakonas, S., . Synthese von Peptidsubstraten fuer alpha Chymotrypsin. Diplomarbeit bei Prof Dr.V. Prelog. Organisch-chemisches Laboratorium der Eidgenoessissen Technischen Hochschule, Zuerich. 1970.
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