Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

George Tegos, PH.D.

TitleInstructor in Dermatology
InstitutionMassachusetts General Hospital
DepartmentDermatology
AddressMassachusetts General Hospital
Wellman Center for Photomedicine, Bartlett 4
55 Fruit St
Boston MA 02114
Phone617/726-3532

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Kourtesi C, Ball AR, Huang YY, Jachak SM, Vera DM, Khondkar P, Gibbons S, Hamblin MR, Tegos GP. Microbial efflux systems and inhibitors: approaches to drug discovery and the challenge of clinical implementation. Open Microbiol J. 2013; 7:34-52.
    View in: PubMed
  2. Chibebe Junior J, Fuchs BB, Sabino CP, Junqueira JC, Jorge AO, Ribeiro MS, Gilmore MS, Rice LB, Tegos GP, Hamblin MR, Mylonakis E. Photodynamic and Antibiotic Therapy Impair the Pathogenesis of Enterococcus faecium in a Whole Animal Insect Model. PLoS One. 2013; 8(2):e55926.
    View in: PubMed
  3. Prates RA, Fuchs BB, Mizuno K, Naqvi Q, Kato IT, Ribeiro MS, Mylonakis E, Tegos GP, Hamblin MR. Effect of Virulence Factors on the Photodynamic Inactivation of Cryptococcus neoformans. PLoS One. 2013; 8(1):e54387.
    View in: PubMed
  4. Dai T, Gupta A, Huang YY, Yin R, Murray CK, Vrahas MS, Sherwood ME, Tegos GP, Hamblin MR. Blue Light Rescues Mice from Potentially Fatal Pseudomonas aeruginosa Burn Infection: Efficacy, Safety, and Mechanism of Action. Antimicrob Agents Chemother. 2013 Mar; 57(3):1238-45.
    View in: PubMed
  5. Kato IT, Prates RA, Sabino CP, Fuchs BB, Tegos GP, Mylonakis E, Hamblin MR, Ribeiro MS. Antimicrobial Photodynamic Inactivation Inhibits Candida albicans Virulence Factors and Reduces In Vivo Pathogenicity. Antimicrob Agents Chemother. 2013 Jan; 57(1):445-51.
    View in: PubMed
  6. Dai T, Murray CK, Vrahas MS, Baer DG, Tegos GP, Hamblin MR. Ultraviolet C light for Acinetobacter baumannii wound infections in mice: potential use for battlefield wound decontamination? J Trauma Acute Care Surg. 2012 Sep; 73(3):661-7.
    View in: PubMed
  7. Strouse JJ, Ivnitski-Steele I, Khawaja HM, Perez D, Ricci J, Yao T, Weiner WS, Schroeder CE, Simpson DS, Maki BE, Li K, Golden JE, Foutz TD, Waller A, Evangelisti AM, Young SM, Chavez SE, Garcia MJ, Ursu O, Bologa CG, Carter MB, Salas VM, Gouveia K, Tegos GP, Oprea TI, Edwards BS, Aubé J, Larson RS, Sklar LA. A Selective ATP-Binding Cassette Subfamily G Member 2 Efflux Inhibitor Revealed via High-Throughput Flow Cytometry. J Biomol Screen. 2013 Jan; 18(1):26-38.
    View in: PubMed
  8. Dai T, Gupta A, Murray CK, Vrahas MS, Tegos GP, Hamblin MR. Blue light for infectious diseases: Propionibacterium acnes, Helicobacter pylori, and beyond? Drug Resist Updat. 2012 Aug; 15(4):223-36.
    View in: PubMed
  9. Polireddy K, Khan MM, Chavan H, Young S, Ma X, Waller A, Garcia M, Perez D, Chavez S, Strouse JJ, Haynes MK, Bologa CG, Oprea TI, Tegos GP, Sklar LA, Krishnamurthy P. A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6. PLoS One. 2012; 7(7):e40005.
    View in: PubMed
  10. Tegos GP, Haynes MK, Schweizer HP. Dissecting novel virulent determinants in the Burkholderia cepacia complex. Virulence. 2012 May 1; 3(3):234-7.
    View in: PubMed
  11. Dai T, Fuchs BB, Coleman JJ, Prates RA, Astrakas C, St Denis TG, Ribeiro MS, Mylonakis E, Hamblin MR, Tegos GP. Concepts and principles of photodynamic therapy as an alternative antifungal discovery platform. Front Microbiol. 2012; 3:120.
    View in: PubMed
  12. Vera DM, Haynes MH, Ball AR, Dai T, Astrakas C, Kelso MJ, Hamblin MR, Tegos GP. Strategies to potentiate antimicrobial photoinactivation by overcoming resistant phenotypes. Photochem Photobiol. 2012 May-Jun; 88(3):499-511.
    View in: PubMed
  13. St Denis TG, Dai T, Izikson L, Astrakas C, Anderson RR, Hamblin MR, Tegos GP. All you need is light: antimicrobial photoinactivation as an evolving and emerging discovery strategy against infectious disease. Virulence. 2011 Nov-Dec; 2(6):509-20.
    View in: PubMed
  14. Apidianakis Y, Que YA, Xu W, Tegos GP, Zimniak P, Hamblin MR, Tompkins RG, Xiao W, Rahme LG. Down-regulation of glutatione S-transferase a 4 (hGSTA4) in the muscle of thermally injured patients is indicative of susceptibility to bacterial infection. FASEB J. 2012 Feb; 26(2):730-7.
    View in: PubMed
  15. Dai T, Bil de Arce VJ, Tegos GP, Hamblin MR. Blue dye and red light, a dynamic combination for prophylaxis and treatment of cutaneous Candida albicans infections in mice. Antimicrob Agents Chemother. 2011 Dec; 55(12):5710-7.
    View in: PubMed
  16. Prates RA, Kato IT, Ribeiro MS, Tegos GP, Hamblin MR. Influence of multidrug efflux systems on methylene blue-mediated photodynamic inactivation of Candida albicans. J Antimicrob Chemother. 2011 Jul; 66(7):1525-32.
    View in: PubMed
  17. Huang L, Dai T, Xuan Y, Tegos GP, Hamblin MR. Synergistic combination of chitosan acetate with nanoparticle silver as a topical antimicrobial: efficacy against bacterial burn infections. Antimicrob Agents Chemother. 2011 Jul; 55(7):3432-8.
    View in: PubMed
  18. Fiamegos YC, Kastritis PL, Exarchou V, Han H, Bonvin AM, Vervoort J, Lewis K, Hamblin MR, Tegos GP. Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria. PLoS One. 2011; 6(4):e18127.
    View in: PubMed
  19. Sharma SK, Dai T, Kharkwal GB, Huang YY, Huang L, De Arce VJ, Tegos GP, Hamblin MR. Drug discovery of antimicrobial photosensitizers using animal models. Curr Pharm Des. 2011; 17(13):1303-19.
    View in: PubMed
  20. Tegos GP, Haynes M, Strouse JJ, Khan MM, Bologa CG, Oprea TI, Sklar LA. Microbial efflux pump inhibition: tactics and strategies. Curr Pharm Des. 2011; 17(13):1291-302.
    View in: PubMed
  21. Lu Z, Dai T, Huang L, Kurup DB, Tegos GP, Jahnke A, Wharton T, Hamblin MR. Photodynamic therapy with a cationic functionalized fullerene rescues mice from fatal wound infections. Nanomedicine (Lond). 2010 Dec; 5(10):1525-33.
    View in: PubMed
  22. Dai T, Tegos GP, St Denis TG, Anderson D, Sinofsky E, Hamblin MR. Ultraviolet-C irradiation for prevention of central venous catheter-related infections: an in vitro study. Photochem Photobiol. 2011 Jan-Feb; 87(1):250-5.
    View in: PubMed
  23. Kishen A, Upadya M, Tegos GP, Hamblin MR. Efflux pump inhibitor potentiates antimicrobial photodynamic inactivation of Enterococcus faecalis biofilm. Photochem Photobiol. 2010 Nov-Dec; 86(6):1343-9.
    View in: PubMed
  24. Huang L, Huang YY, Mroz P, Tegos GP, Zhiyentayev T, Sharma SK, Lu Z, Balasubramanian T, Krayer M, Ruzié C, Yang E, Kee HL, Kirmaier C, Diers JR, Bocian DF, Holten D, Lindsey JS, Hamblin MR. Stable synthetic cationic bacteriochlorins as selective antimicrobial photosensitizers. Antimicrob Agents Chemother. 2010 Sep; 54(9):3834-41.
    View in: PubMed
  25. Ragàs X, Dai T, Tegos GP, Agut M, Nonell S, Hamblin MR. Photodynamic inactivation of Acinetobacter baumannii using phenothiazinium dyes: in vitro and in vivo studies. Lasers Surg Med. 2010 Jul; 42(5):384-90.
    View in: PubMed
  26. Coleman JJ, Okoli I, Tegos GP, Holson EB, Wagner FF, Hamblin MR, Mylonakis E. Characterization of plant-derived saponin natural products against Candida albicans. ACS Chem Biol. 2010 Mar 19; 5(3):321-32.
    View in: PubMed
  27. Dai T, Tegos GP, Zhiyentayev T, Mylonakis E, Hamblin MR. Photodynamic therapy for methicillin-resistant Staphylococcus aureus infection in a mouse skin abrasion model. Lasers Surg Med. 2010 Jan; 42(1):38-44.
    View in: PubMed
  28. Huang L, Terakawa M, Zhiyentayev T, Huang YY, Sawayama Y, Jahnke A, Tegos GP, Wharton T, Hamblin MR. Innovative cationic fullerenes as broad-spectrum light-activated antimicrobials. Nanomedicine. 2010 Jun; 6(3):442-52.
    View in: PubMed
  29. Dai T, Tegos GP, Lu Z, Huang L, Zhiyentayev T, Franklin MJ, Baer DG, Hamblin MR. Photodynamic therapy for Acinetobacter baumannii burn infections in mice. Antimicrob Agents Chemother. 2009 Sep; 53(9):3929-34.
    View in: PubMed
  30. Dai T, Tegos GP, Burkatovskaya M, Castano AP, Hamblin MR. Chitosan acetate bandage as a topical antimicrobial dressing for infected burns. Antimicrob Agents Chemother. 2009 Feb; 53(2):393-400.
    View in: PubMed
  31. Tegos GP, Masago K, Aziz F, Higginbotham A, Stermitz FR, Hamblin MR. Inhibitors of bacterial multidrug efflux pumps potentiate antimicrobial photoinactivation. Antimicrob Agents Chemother. 2008 Sep; 52(9):3202-9.
    View in: PubMed
  32. Burkatovskaya M, Castano AP, Demidova-Rice TN, Tegos GP, Hamblin MR. Effect of chitosan acetate bandage on wound healing in infected and noninfected wounds in mice. Wound Repair Regen. 2008 May-Jun; 16(3):425-31.
    View in: PubMed
  33. Dai T, Tegos GP, Rolz-Cruz G, Cumbie WE, Hamblin MR. Ultraviolet C inactivation of dermatophytes: implications for treatment of onychomycosis. Br J Dermatol. 2008 Jun; 158(6):1239-46.
    View in: PubMed
  34. Apidianakis Y, Mindrinos MN, Xiao W, Tegos GP, Papisov MI, Hamblin MR, Davis RW, Tompkins RG, Rahme LG. Involvement of skeletal muscle gene regulatory network in susceptibility to wound infection following trauma. PLoS One. 2007; 2(12):e1356.
    View in: PubMed
  35. Mroz P, Tegos GP, Gali H, Wharton T, Sarna T, Hamblin MR. Photodynamic therapy with fullerenes. Photochem Photobiol Sci. 2007 Nov; 6(11):1139-49.
    View in: PubMed
  36. Fuchs BB, Tegos GP, Hamblin MR, Mylonakis E. Susceptibility of Cryptococcus neoformans to photodynamic inactivation is associated with cell wall integrity. Antimicrob Agents Chemother. 2007 Aug; 51(8):2929-36.
    View in: PubMed
  37. Garcez AS, Ribeiro MS, Tegos GP, Núñez SC, Jorge AO, Hamblin MR. Antimicrobial photodynamic therapy combined with conventional endodontic treatment to eliminate root canal biofilm infection. Lasers Surg Med. 2007 Jan; 39(1):59-66.
    View in: PubMed
  38. Burkatovskaya M, Tegos GP, Swietlik E, Demidova TN, P Castano A, Hamblin MR. Use of chitosan bandage to prevent fatal infections developing from highly contaminated wounds in mice. Biomaterials. 2006 Aug; 27(22):4157-64.
    View in: PubMed
  39. Tegos GP, Anbe M, Yang C, Demidova TN, Satti M, Mroz P, Janjua S, Gad F, Hamblin MR. Protease-stable polycationic photosensitizer conjugates between polyethyleneimine and chlorin(e6) for broad-spectrum antimicrobial photoinactivation. Antimicrob Agents Chemother. 2006 Apr; 50(4):1402-10.
    View in: PubMed
  40. Belofsky G, Carreno R, Lewis K, Ball A, Casadei G, Tegos GP. Metabolites of the "smoke tree", Dalea spinosa, potentiate antibiotic activity against multidrug-resistant Staphylococcus aureus. J Nat Prod. 2006 Feb; 69(2):261-4.
    View in: PubMed
  41. Tegos GP, Hamblin MR. Phenothiazinium antimicrobial photosensitizers are substrates of bacterial multidrug resistance pumps. Antimicrob Agents Chemother. 2006 Jan; 50(1):196-203.
    View in: PubMed
  42. G. Tegos . Natural substrates and Inhibitors of Multidrug Resistant Pumps (MDRs) redefine the plant antimicrobials. In Naturally occurring bioactive compounds: a new and safe alternative for control of pests and microbial diseases. 2006.
  43. Tegos GP, Demidova TN, Arcila-Lopez D, Lee H, Wharton T, Gali H, Hamblin MR. Cationic fullerenes are effective and selective antimicrobial photosensitizers. Chem Biol. 2005 Oct; 12(10):1127-35.
    View in: PubMed
  44. Belofsky G, Percivill D, Lewis K, Tegos GP, Ekart J. Phenolic metabolites of Dalea versicolor that enhance antibiotic activity against model pathogenic bacteria. J Nat Prod. 2004 Mar; 67(3):481-4.
    View in: PubMed
  45. Morel C, Stermitz FR, Tegos G, Lewis K. Isoflavones as potentiators of antibacterial activity. J Agric Food Chem. 2003 Sep 10; 51(19):5677-9.
    View in: PubMed
  46. Stermitz FR, Cashman KK, Halligan KM, Morel C, Tegos GP, Lewis K. Polyacylated neohesperidosides from Geranium caespitosum: bacterial multidrug resistance pump inhibitors. Bioorg Med Chem Lett. 2003 Jun 2; 13(11):1915-8.
    View in: PubMed
  47. Stermitz FR, Scriven LN, Tegos G, Lewis K. Two flavonols from Artemisa annua which potentiate the activity of berberine and norfloxacin against a resistant strain of Staphylococcus aureus. Planta Med. 2002 Dec; 68(12):1140-1.
    View in: PubMed
  48. Tegos G, Stermitz FR, Lomovskaya O, Lewis K. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. Antimicrob Agents Chemother. 2002 Oct; 46(10):3133-41.
    View in: PubMed
  49. Tegos G, Vargas C, Perysinakis A, Koukkou AI, Christogianni A, Nieto JJ, Ventosa A, Drainas C. Release of cell-free ice nuclei from Halomonas elongata expressing the ice nucleation gene inaZ of Pseudomonas syringae. J Appl Microbiol. 2000 Nov; 89(5):785-92.
    View in: PubMed
  50. Coronado MJ, Vargas C, Mellado E, Tegos G, Drainas C, Nieto JJ, Ventosa A. The alpha-amylase gene amyH of the moderate halophile Halomonas meridiana: cloning and molecular characterization. Microbiology. 2000 Apr; 146 ( Pt 4):861-8.
    View in: PubMed
  51. Vargas C, Tegos G, Vartholomatos G, Drainas C, Ventosa A, Nieto JJ. Genetic organization of the mobilization region of the plasmid pHE1 from Halomonas elongata. Syst Appl Microbiol. 1999 Dec; 22(4):520-9.
    View in: PubMed
  52. Vargas C, Tegos G, Drainas C, Ventosa A, Nieto JJ. Analysis of the replication region of the cryptic plasmid pHE1 from the moderate halophile Halomonas elongata. Mol Gen Genet. 1999 Jun; 261(4-5):851-61.
    View in: PubMed
  53. Afendra AS, Vartholomatos G, Varsaki A, Tegos G, Drainas C . A new high expression vector for the production of ice nuclei from Zymomonas mobilis CP4 strains. Biotechnology Letters. 1998; 20:647-651.
  54. Tegos G, Vargas C, Vartholomatos G, Perysinakis A, Nieto JJ, Ventosa A, Drainas C. Identification of a promoter region on the Halomonas elongata cryptic plasmid pHE1 employing the inaZ reporter gene of Pseudomonas syringae. FEMS Microbiol Lett. 1997 Sep 1; 154(1):45-51.
    View in: PubMed
  55. Arvanitis N, Vargas C, Tegos G, Perysinakis A, Nieto JJ, Ventosa A, Drainas C. Development of a gene reporter system in moderately halophilic bacteria by employing the ice nucleation gene of Pseudomonas syringae. Appl Environ Microbiol. 1995 Nov; 61(11):3821-5.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Tegos's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
See all (233) concept(s)
_
Co-Authors
See all (14) people
_
Similar People
See all (60) people
_
Same Department
Search Department
Physical Neighbors
_