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Matthew J. Mahon, PH.D.

TitleAssistant Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Endocrine, THR 1051
50 Blossom St
Boston MA 02114
Phone617/726-4667
Fax617/726-7543

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Guo J, Song L, Liu M, Mahon MJ. Fluorescent ligand-directed co-localization of the parathyroid hormone 1 receptor with the brush-border scaffold complex of the proximal tubule reveals hormone-dependent changes in ezrin immunoreactivity consistent with inactivation. Biochim Biophys Acta. 2012 Dec; 1823(12):2243-53.
    View in: PubMed
  2. Mahon MJ. The parathyroid hormone receptorsome and the potential for therapeutic intervention. Curr Drug Targets. 2012 Jan; 13(1):116-28.
    View in: PubMed
  3. Mahon MJ. Vectors bicistronically linking a gene of interest to the SV40 large T antigen in combination with the SV40 origin of replication enhance transient protein expression and luciferase reporter activity. Biotechniques. 2011 Aug; 51(2):119-28.
    View in: PubMed
  4. Mahon MJ. Apical membrane segregation of phosphatidylinositol-4,5-bisphosphate influences parathyroid hormone 1 receptor compartmental signaling and localization via direct regulation of ezrin in LLC-PK1 cells. Cell Signal. 2011 Oct; 23(10):1659-68.
    View in: PubMed
  5. Nagai S, Okazaki M, Segawa H, Bergwitz C, Dean T, Potts JT, Mahon MJ, Gardella TJ, Jüppner H. Acute down-regulation of sodium-dependent phosphate transporter NPT2a involves predominantly the cAMP/PKA pathway as revealed by signaling-selective parathyroid hormone analogs. J Biol Chem. 2011 Jan 14; 286(2):1618-26.
    View in: PubMed
  6. Mariot V, Wu JY, Aydin C, Mantovani G, Mahon MJ, Linglart A, Bastepe M. Potent constitutive cyclic AMP-generating activity of XLas implicates this imprinted GNAS product in the pathogenesis of McCune-Albright syndrome and fibrous dysplasia of bone. Bone. 2011 Feb; 48(2):312-20.
    View in: PubMed
  7. Mahon MJ. The parathyroid hormone 1 receptor directly binds to the FERM domain of ezrin, an interaction that supports apical receptor localization and signaling in LLC-PK1 cells. Mol Endocrinol. 2009 Oct; 23(10):1691-701.
    View in: PubMed
  8. Mahon MJ. Ezrin promotes functional expression and parathyroid hormone-mediated regulation of the sodium-phosphate cotransporter 2a in LLC-PK1 cells. Am J Physiol Renal Physiol. 2008 Mar; 294(3):F667-75.
    View in: PubMed
  9. Selim AA, Mahon M, Juppner H, Bringhurst FR, Divieti P. Role of calcium channels in carboxyl-terminal parathyroid hormone receptor signaling. Am J Physiol Cell Physiol. 2006 Jul; 291(1):C114-21.
    View in: PubMed
  10. Linglart A, Mahon MJ, Kerachian MA, Berlach DM, Hendy GN, Jüppner H, Bastepe M. Coding GNAS mutations leading to hormone resistance impair in vitro agonist- and cholera toxin-induced adenosine cyclic 3',5'-monophosphate formation mediated by human XLalphas. Endocrinology. 2006 May; 147(5):2253-62.
    View in: PubMed
  11. Tharp WG, Yadav R, Irimia D, Upadhyaya A, Samadani A, Hurtado O, Liu SY, Munisamy S, Brainard DM, Mahon MJ, Nourshargh S, van Oudenaarden A, Toner MG, Poznansky MC. Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo. J Leukoc Biol. 2006 Mar; 79(3):539-54.
    View in: PubMed
  12. Dean T, Linglart A, Mahon MJ, Bastepe M, Jüppner H, Potts JT, Gardella TJ. Mechanisms of ligand binding to the parathyroid hormone (PTH)/PTH-related protein receptor: selectivity of a modified PTH(1-15) radioligand for GalphaS-coupled receptor conformations. Mol Endocrinol. 2006 Apr; 20(4):931-43.
    View in: PubMed
  13. Mahon MJ, Bonacci TM, Divieti P, Smrcka AV. A docking site for G protein ß? subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways. Mol Endocrinol. 2006 Jan; 20(1):136-46.
    View in: PubMed
  14. Mahon, MJ, Bonacci, TM, Divieti, P, Smrcka, AV . A docking site for G protein bg subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways. Molecular Endocrinology. 2005; epub ahead of publication.
  15. Shimada M, Mahon MJ, Greer PA, Segre GV. The receptor for parathyroid hormone and parathyroid hormone-related peptide is hydrolyzed and its signaling properties are altered by directly binding the calpain small subunit. Endocrinology. 2005 May; 146(5):2336-44.
    View in: PubMed
  16. Mahon MJ, Shimada M. Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors. FEBS Lett. 2005 Jan 31; 579(3):803-7.
    View in: PubMed
  17. Mahon MJ, Segre GV. Stimulation by parathyroid hormone of a NHERF-1-assembled complex consisting of the parathyroid hormone I receptor, phospholipase Cbeta, and actin increases intracellular calcium in opossum kidney cells. J Biol Chem. 2004 May 28; 279(22):23550-8.
    View in: PubMed
  18. Mahon MJ, Cole JA, Lederer ED, Segre GV. Na+/H+ exchanger-regulatory factor 1 mediates inhibition of phosphate transport by parathyroid hormone and second messengers by acting at multiple sites in opossum kidney cells. Mol Endocrinol. 2003 Nov; 17(11):2355-64.
    View in: PubMed
  19. Mahon MJ, Donowitz M, Yun CC, Segre GV. Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature. 2002 Jun 20; 417(6891):858-61.
    View in: PubMed
  20. Mahon MJ, Donowitz M, Yun CC, Segre GV . Na+/H+ exchanger regulatory factor 2 transfers PTH/PTHrP receptor signaling from adenylyl cyclase to phospholipase c. Nature. 2002; 417(6891):858-861.
  21. Seol W, Mahon MJ, Lee YK, Moore DD. Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13/N-CoR. Mol Endocrinol. 1996 Dec; 10(12):1646-55.
    View in: PubMed
  22. Seol W, Mahon MJ, Lee Y-K, Moore DD . Two receptor interacting domains in the nuclear hormone receptor co-repressor RIP13/NCoR. Molecular Endocrinology. 1996; 10(12):1646-55.
  23. Mahon MJ, Gasiewicz TA. Ah receptor phosphorylation: localization of phosphorylation sites to the C-terminal half of the protein. Arch Biochem Biophys. 1995 Apr 1; 318(1):166-74.
    View in: PubMed
  24. Mahon MJ, Gasiewicz TA. Chelatable metal ions are not required for aryl hydrocarbon receptor transformation to a DNA binding form: phenanthrolines are possible competitive antagonists of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch Biochem Biophys. 1992 Aug 15; 297(1):1-8.
    View in: PubMed
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