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Alessandro Doria, PH.D., M.D.

TitleAssociate Professor of Medicine
InstitutionJoslin Diabetes Center
DepartmentMedicine
AddressJoslin Diabetes Center
Research Division
One Joslin Place
Boston MA 02215
Phone617/732-2406
Fax617/732-2667

 Research 
 research resources
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in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Genetics Core (JDC) - Core services (5) and Instruments (3)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. De Cosmo S, Prudente S, Lamacchia O, Pucci L, Lucchesi D, Mendonca C, Bailetti D, Copetti M, Pellegrini F, Cignarelli M, Penno G, Doria A, Trischitta V. The IRS1 G972R polymorphism and glomerular filtration rate in patients with type 2 diabetes of European ancestry. Nephrol Dial Transplant. 2013 Dec; 28(12):3031-4.
    View in: PubMed
  2. Qi L, Qi Q, Prudente S, Mendonca C, Andreozzi F, di Pietro N, Sturma M, Novelli V, Mannino GC, Formoso G, Gervino EV, Hauser TH, Muehlschlegel JD, Niewczas MA, Krolewski AS, Biolo G, Pandolfi A, Rimm E, Sesti G, Trischitta V, Hu F, Doria A. Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. JAMA. 2013 Aug 28; 310(8):821-8.
    View in: PubMed
  3. Krolewski AS, Niewczas MA, Skupien J, Gohda T, Smiles A, Eckfeldt JH, Doria A, Warram JH. Early progressive renal decline precedes the onset of microalbuminuria and its progression to macroalbuminuria. Diabetes Care. 2014 Jan; 37(1):226-34.
    View in: PubMed
  4. Maahs DM, Caramori L, Cherney DZ, Galecki AT, Gao C, Jalal D, Perkins BA, Pop-Busui R, Rossing P, Mauer M, Doria A. Uric Acid Lowering to Prevent Kidney Function Loss in Diabetes: The Preventing Early Renal Function Loss (PERL) Allopurinol Study. Curr Diab Rep. 2013 Aug; 13(4):550-9.
    View in: PubMed
  5. Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert MF, Warren LL, Stancáková A, Buxbaum SG, Lyytikäinen LP, Henneman P, Wu Y, Cheung CY, Pankow JS, Jackson AU, Gustafsson S, Zhao JH, Ballantyne CM, Xie W, Bergman RN, Boehnke M, El Bouazzaoui F, Collins FS, Dunn SH, Dupuis J, Forouhi NG, Gillson C, Hattersley AT, Hong J, Kähönen M, Kuusisto J, Kedenko L, Kronenberg F, Doria A, Assimes TL, Ferrannini E, Hansen T, Hao K, Häring H, Knowles JW, Lindgren CM, Nolan JJ, Paananen J, Pedersen O, Quertermous T, Smith U, Lehtimäki T, Liu CT, Loos RJ, McCarthy MI, Morris AD, Vasan RS, Spector TD, Teslovich TM, Tuomilehto J, van Dijk KW, Viikari JS, Zhu N, Langenberg C, Ingelsson E, Semple RK, Sinaiko AR, Palmer CN, Walker M, Lam KS, Paulweber B, Mohlke KL, van Duijn C, Raitakari OT, Bidulescu A, Wareham NJ, Laakso M, Waterworth DM, Lawlor DA, Meigs JB, Richards JB, Frayling TM. Mendelian randomization studies do not support a causal role for reduced circulating adiponectin levels in insulin resistance and type 2 diabetes. Diabetes. 2013 Oct; 62(10):3589-98.
    View in: PubMed
  6. Menzaghi C, Bacci S, Salvemini L, Mendonca C, Palladino G, Fontana A, De Bonis C, Marucci A, Goheen E, Prudente S, Morini E, Rizza S, Kanagaki A, Fini G, Mangiacotti D, Federici M, De Cosmo S, Pellegrini F, Doria A, Trischitta V. Serum resistin, cardiovascular disease and all-cause mortality in patients with type 2 diabetes. PLoS One. 2013; 8(6):e64729.
    View in: PubMed
  7. Prudente S, Morini E, Marselli L, Baratta R, Copetti M, Mendonca C, Andreozzi F, Chandalia M, Pellegrini F, Bailetti D, Alberico F, Shah H, Abate N, Sesti G, Frittitta L, Marchetti P, Doria A, Trischitta V. Joint effect of insulin signaling genes on insulin secretion and glucose homeostasis. J Clin Endocrinol Metab. 2013 Jun; 98(6):E1143-7.
    View in: PubMed
  8. Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 2013 Feb; 19(2):217-26.
    View in: PubMed
  9. Bacci S, Prudente S, Copetti M, Spoto B, Rizza S, Baratta R, Di Pietro N, Morini E, Di Paola R, Testa A, Mallamaci F, Tripepi G, Zhang YY, Mercuri L, Di Silvestre S, Lauro R, Malatino L, Consoli A, Pellegrini F, Pandolfi A, Frittitta L, Zoccali C, Federici M, Doria A, Trischitta V. Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance. Atherosclerosis. 2013 Jan; 226(1):140-5.
    View in: PubMed
  10. Doria A, Niewczas MA, Fiorina P. Can existing drugs approved for other indications retard renal function decline in patients with type 1 diabetes and nephropathy? Semin Nephrol. 2012 Sep; 32(5):437-44.
    View in: PubMed
  11. Menzaghi C, Salvemini L, Fini G, Thompson R, Mangiacotti D, Di Paola R, Morini E, Giorelli M, De Bonis C, De Cosmo S, Doria A, Trischitta V. Serum resistin and kidney function: a family-based study in non-diabetic, untreated individuals. PLoS One. 2012; 7(6):e38414.
    View in: PubMed
  12. De Cosmo S, Prudente S, Lamacchia O, Lucchesi D, Shah H, Mendonca C, Pucci L, Mercuri L, Gervino EV, Hauser TH, Bailetti D, Penno G, Cignarelli M, Doria A, Trischitta V. The 9p21 coronary artery disease locus and kidney dysfunction in patients with Type 2 diabetes mellitus. Nephrol Dial Transplant. 2012 Dec; 27(12):4411-3.
    View in: PubMed
  13. Qi Q, Liang L, Doria A, Hu FB, Qi L. Genetic predisposition to dyslipidemia and type 2 diabetes risk in two prospective cohorts. Diabetes. 2012 Mar; 61(3):745-52.
    View in: PubMed
  14. Niewczas MA, Gohda T, Skupien J, Smiles AM, Walker WH, Rosetti F, Cullere X, Eckfeldt JH, Doria A, Mayadas TN, Warram JH, Krolewski AS. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol. 2012 Mar; 23(3):507-15.
    View in: PubMed
  15. Qi L, Parast L, Cai T, Powers C, Gervino EV, Hauser TH, Hu FB, Doria A. Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies. J Am Coll Cardiol. 2011 Dec 13; 58(25):2675-82.
    View in: PubMed
  16. Prudente S, Morini E, Larmon J, Andreozzi F, Di Pietro N, Nigro A, Gervino EV, Mannino GC, Bacci S, Hauser TH, Bellacchio E, Formoso G, Pellegrini F, Proto V, Menzaghi C, Frittitta L, Pandolfi A, Sesti G, Doria A, Trischitta V. The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells. Atherosclerosis. 2011 Dec; 219(2):667-72.
    View in: PubMed
  17. Doria A, Krolewski AS. Diabetes: Lowering serum uric acid levels to prevent kidney failure. Nat Rev Nephrol. 2011 Sep; 7(9):495-6.
    View in: PubMed
  18. Sun JK, Keenan HA, Cavallerano JD, Asztalos BF, Schaefer EJ, Sell DR, Strauch CM, Monnier VM, Doria A, Aiello LP, King GL. Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: the joslin 50-year medalist study. Diabetes Care. 2011 Apr; 34(4):968-74.
    View in: PubMed
  19. Bacci S, Rizza S, Prudente S, Spoto B, Powers C, Facciorusso A, Pacilli A, Lauro D, Testa A, Zhang YY, Di Stolfo G, Mallamaci F, Tripepi G, Xu R, Mangiacotti D, Aucella F, Lauro R, Gervino EV, Hauser TH, Copetti M, De Cosmo S, Pellegrini F, Zoccali C, Federici M, Doria A, Trischitta V. The ENPP1 Q121 variant predicts major cardiovascular events in high-risk individuals: evidence for interaction with obesity in diabetic patients. Diabetes. 2011 Mar; 60(3):1000-7.
    View in: PubMed
  20. Sharma R, Prudente S, Andreozzi F, Powers C, Mannino G, Bacci S, Gervino EV, Hauser TH, Succurro E, Mercuri L, Goheen EH, Shah H, Trischitta V, Sesti G, Doria A. The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects. Atherosclerosis. 2011 May; 216(1):157-60.
    View in: PubMed
  21. Doria A. Genetics of diabetes complications. Curr Diab Rep. 2010 Dec; 10(6):467-75.
    View in: PubMed
  22. Keenan HA, Sun JK, Levine J, Doria A, Aiello LP, Eisenbarth G, Bonner-Weir S, King GL. Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes. 2010 Nov; 59(11):2846-53.
    View in: PubMed
  23. Ficociello LH, Rosolowsky ET, Niewczas MA, Maselli NJ, Weinberg JM, Aschengrau A, Eckfeldt JH, Stanton RC, Galecki AT, Doria A, Warram JH, Krolewski AS. High-Normal Serum Uric Acid Increases Risk of Early Declining Renal Function In Type 1 Diabetes: Results of 6-year Follow-up. Diabetes Care. 2010; In Press.
  24. Ficociello LH, Rosolowsky ET, Niewczas MA, Maselli NJ, Weinberg JM, Aschengrau A, Eckfeldt JH, Stanton RC, Galecki AT, Doria A, Warram JH, Krolewski AS. High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up. Diabetes Care. 2010 Jun; 33(6):1337-43.
    View in: PubMed
  25. Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14460-5.
    View in: PubMed
  26. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009 Aug; 15(8):940-5.
    View in: PubMed
  27. Morini E, Prudente S, Succurro E, Chandalia M, Zhang YY, Mammarella S, Pellegrini F, Powers C, Proto V, Dallapiccola B, Cama A, Sesti G, Abate N, Doria A, Trischitta V. IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants. Diabetologia. 2009 Sep; 52(9):1852-7.
    View in: PubMed
  28. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009 Apr 9; 360(15):1509-17.
    View in: PubMed
  29. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and significance of brown adipose tissue in human adults. N Engl J Med. 2009; 360(15):1509-17.
  30. Pezzolesi MG, Poznik GD, Mychaleckyj JC, Paterson AD, Barati MT, Klein JB, Ng DP, Placha G, Canani LH, Bochenski J, Waggott D, Merchant ML, Krolewski B, Mirea L, Wanic K, Katavetin P, Kure M, Wolkow P, Dunn JS, Smiles A, Walker WH, Boright AP, Bull SB, Doria A, Rogus JJ, Rich SS, Warram JH, Krolewski AS. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. Diabetes. 2009 Jun; 58(6):1403-10.
    View in: PubMed
  31. Marucci A, Miscio G, Padovano L, Boonyasrisawat W, Florez JC, Doria A, Trischitta V, Di Paola R. The role of HSP70 on ENPP1 expression and insulin-receptor activation. J Mol Med (Berl). 2009 Feb; 87(2):139-44.
    View in: PubMed
  32. Doria A, Wojcik J, Xu R, Gervino EV, Hauser TH, Johnstone MT, Nolan D, Hu FB, Warram JH. Interaction between poor glycemic control and 9p21 locus on risk of coronary artery disease in type 2 diabetes. JAMA. 2008 Nov 26; 300(20):2389-97.
    View in: PubMed
  33. Prudente S, Scarpelli D, Chandalia M, Zhang YY, Morini E, Del Guerra S, Perticone F, Li R, Powers C, Andreozzi F, Marchetti P, Dallapiccola B, Abate N, Doria A, Sesti G, Trischitta V. The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes. J Clin Endocrinol Metab. 2009 Jan; 94(1):190-6.
    View in: PubMed
  34. De Cosmo S, Minenna A, Zhang YY, Thompson R, Thompson R, Miscio G, Vedovato M, Rauseo A, Saller A, Mastroianno S, Pellegrini F, Trevisan R, Fioretto P, Doria A, Trischitta V. Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes. Am J Kidney Dis. 2009 Feb; 53(2):273-80.
    View in: PubMed
  35. Sammalisto S, Hiekkalinna T, Schwander K, Kardia S, Weder AB, Rodriguez BL, Doria A, Kelly JA, Bruner GR, Harley JB, Redline S, Larkin EK, Patel SR, Ewan AJ, Weber JL, Perola M, Peltonen L. Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects. Eur J Hum Genet. 2009 Feb; 17(2):258-66.
    View in: PubMed
  36. Doria A, Patti ME, Kahn CR. The emerging genetic architecture of type 2 diabetes. Cell Metab. 2008 Sep; 8(3):186-200.
    View in: PubMed
  37. Gottardo L, De Cosmo S, Zhang YY, Powers C, Prudente S, Marescotti MC, Trischitta V, Avogaro A, Doria A. A polymorphism at the IL6ST (gp130) locus is associated with traits of the metabolic syndrome. Obesity. 2008; 16(1):205-210.
  38. Doria A, Abumrad NA. Genome-wide associations and metabolic disease: the big revolution. Curr Opin Clin Nutr Metab Care. 2008 Jul; 11(4):363-5.
    View in: PubMed
  39. McAteer JB, Prudente S, Bacci S, Lyon HN, Hirschhorn JN, Trischitta V, Florez JC; ENPP1 Consortium. The ENPP1 K121Q polymorphism is associated with type 2 diabetes in European populations: evidence from an updated meta-analysis in 42,042 subjects. Diabetes. 2008; 57(4):1125-30.
  40. Love-Gregory L, Sherva R, Sun L, Wasson J, Schappe T, Doria A, Rao DC, Hunt SC, Klein S, Neuman RJ, Permutt MA, Abumrad NA. Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Hum Mol Genet. 2008 Jun 1; 17(11):1695-704.
    View in: PubMed
  41. Sebastiani P, Zhao Z, Abad-Grau MM, Riva A, Hartley SW, Sedgewick AE, Doria A, Montano M, Melista E, Terry D, Perls TT, Steinberg MH, Baldwin CT. A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples. BMC Genet. 2008; 9:6.
    View in: PubMed
  42. Gottardo L, De Cosmo S, Zhang YY, Powers C, Prudente S, Marescotti MC, Trischitta V, Avogaro A, Doria A. A polymorphism at the IL6ST (gp130) locus is associated with traits of the metabolic syndrome. Obesity (Silver Spring). 2008 Jan; 16(1):205-10.
    View in: PubMed
  43. De Cosmo S, Prudente S, Andreozzi F, Morini E, Rauseo A, Scarpelli D, Zhang YY, Xu R, Perticone F, Dallapiccola B, Sesti G, Doria A, Trischitta V. Glutamine to arginine substitution at amino acid 84 of mammalian tribbles homolog TRIB3 and CKD in whites with type 2 diabetes. Am J Kidney Dis. 2007 Oct; 50(4):688-9.
    View in: PubMed
  44. Borowiec M, Thompson R, Powers C, Xu R, Dickey T, Doria A. Mutations in the SLC30A8 gene are not a major cause of MODY or other forms of early-onset, autosomal dominant type 2 diabetes. Diabetologia. 2007 Oct; 50(10):2224-6.
    View in: PubMed
  45. Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol. 2007 Aug; 9(8):970-7.
    View in: PubMed
  46. Doria A, Abumrad NA. Why Type 2 Diabetes is not an equal opportunity disease: recent progress in genetics. Curr Opin Clin Nutr Metab Care. 2007; 10(4):389-90.
  47. Keenan HA, Costacou T, Sun JK, Doria A, Cavellerano J, Coney J, Orchard TJ, Aiello LP, King GL. Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study. Diabetes Care. 2007 Aug; 30(8):1995-7.
    View in: PubMed
  48. Plengvidhya N, Kooptiwut S, Songtawee N, Doi A, Furuta H, Nishi M, Nanjo K, Tantibhedhyangkul W, Boonyasrisawat W, Yenchitsomanus PT, Doria A, Banchuin N. PAX4 mutations in Thais with maturity onset diabetes of the young. J Clin Endocrinol Metab. 2007 Jul; 92(7):2821-6.
    View in: PubMed
  49. Qi L, Doria A, Giorgi E, Hu FB. Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in women: a tagging-single nucleotide polymorphism haplotype analysis. Diabetes. 2007 Jun; 56(6):1586-91.
    View in: PubMed
  50. Alessandro Doria, Vincenzo Trischitta. Methods of diagnosing cardiovascular disease (Pending). 2007.
  51. Keenan HA, Poznik GD, Varo N, Schneider J, Almasy L, Warram JH, Duggirala R, Schoenbeck U, Krolewski AS, Doria A. Identification of a locus modulating serum C-reactive protein levels on chromosome 5p15. Atherosclerosis. 2008 Feb; 196(2):863-70.
    View in: PubMed
  52. Menzaghi C, Trischitta V, Doria A. Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease. Diabetes. 2007 May; 56(5):1198-209.
    View in: PubMed
  53. Boonyasrisawat W, Eberle D, Bacci S, Zhang YY, Nolan D, Gervino EV, Johnstone MT, Trischitta V, Shoelson SE, Doria A. Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes. Diabetes. 2007 Feb; 56(2):499-505.
    View in: PubMed
  54. Powers C, Placha G, Gottardo L, Gesta S, Avogaro A, Kahn CR, Doria A. Sequence Variants in the Developmental Gene T-box 15 (TBX15) Are Major Modulators of Body Weight and Waist Circumference. Diabetes. 2007; 56 (Suppl. 1):A70.
  55. Boonyasrisawat W, Liew CW, Borowiec M, Doria A. . Variants at the A20 (TNFAIP3) Locus Influence Cardiovascular Risk in Type 2 Diabetes by Modifying the Activity of Intronic Regulatory Elements. Diabetes. 2007; 56 (Suppl. 1):A185.
  56. Zhang YY, Boonyasrisawat W, Xu R, Nolan D, Johnstone MT, Gervino EV, Doria A. Polymorphisms at the Adiponectin Receptor T-Cadherin (CDH13) Locus Are Associated with Increased Cardiovascular Risk in Type 2 Diabetes. Diabetes. 2007; 56 (Suppl.1):A303.
  57. Zhang YY, Gottardo L, Thompson R, Powers C, Nolan D, Duffy J, Marescotti MC, Avogaro A, Doria A. A visfatin promoter polymorphism is associated with low-grade inflammation and type 2 diabetes. Obesity (Silver Spring). 2006 Dec; 14(12):2119-26.
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  58. Soccio T, Zhang YY, Bacci S, Mlynarski W, Placha G, Raggio G, Di Paola R, Marucci A, Johnstone MT, Gervino EV, Abumrad NA, Klein S, Trischitta V, Doria A. Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. Diabetes. 2006 Oct; 55(10):2763-70.
    View in: PubMed
  59. Dunn JS, Mlynarski WM, Pezzolesi MG, Borowiec M, Powers C, Krolewski AS, Doria A. Examination of PPP1R3B as a candidate gene for the type 2 diabetes and MODY loci on chromosome 8p23. Ann Hum Genet. 2006 Sep; 70(Pt 5):587-93.
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  60. Alessandro Doria, Xiaowei Ma. Methods of diagnosing cardiovascular disease (Pending). 2006.
  61. Menzaghi C, Coco A, Salvemini L, Thompson R, De Cosmo S, Doria A, Trischitta V. Heritability of serum resistin and its genetic correlation with insulin resistance-related features in nondiabetic Caucasians. J Clin Endocrinol Metab. 2006 Jul; 91(7):2792-5.
    View in: PubMed
  62. Qi L, Doria A, Manson JE, Meigs JB, Hunter D, Mantzoros CS, Hu FB. Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes. 2006 May; 55(5):1512-6.
    View in: PubMed
  63. Di Paola R, Ciociola E, Boonyasrisawat W, Nolan D, Duffy J, Miscio G, Cisternino C, Fini G, Tassi V, Doria A, Trischitta V. Association of hGrb10 genetic variations with type 2 diabetes in Caucasian subjects. Diabetes Care. 2006 May; 29(5):1181-3.
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  64. Zhang YY, Gottardo L, Mlynarski W, Frazier W, Nolan D, Duffy J, Marescotti MC, Gervino EV, Johnstone MT, Mantzoros CS, Avogaro A, Doria A. Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels. Atherosclerosis. 2007 Mar; 191(1):121-7.
    View in: PubMed
  65. Bacci S, Ludovico O, Prudente S, Zhang YY, Di Paola R, Mangiacotti D, Rauseo A, Nolan D, Duffy J, Fini G, Salvemini L, Amico C, Vigna C, Pellegrini F, Menzaghi C, Doria A, Trischitta V. The K121Q polymorphism of the ENPP1/PC-1 gene is associated with insulin resistance/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction. Diabetes. 2005 Oct; 54(10):3021-5.
    View in: PubMed
  66. Qi L, Li T, Rimm E, Zhang C, Rifai N, Hunter D, Doria A, Hu FB. The +276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men. Diabetes. 2005 May; 54(5):1607-10.
    View in: PubMed
  67. Varo N, Libby P, Nuzzo R, Italiano J, Doria A, Schönbeck U. Elevated release of sCD40L from platelets of diabetic patients by thrombin, glucose and advanced glycation end products. Diab Vasc Dis Res. 2005 May; 2(2):81-7.
    View in: PubMed
  68. Noushmehr H, D'Amico E, Farilla L, Hui H, Wawrowsky KA, Mlynarski W, Doria A, Abumrad NA, Perfetti R. Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion. Diabetes. 2005 Feb; 54(2):472-81.
    View in: PubMed
  69. Doria A. The genetics of type 2 diabetes. Kahn, CR, Weir, GC, King, GL, Jacobson, AM, Moses, AC, Smith, RJ, (eds.). Joslin’s Diabetes Mellitus. 14th edition. 2005; 371-98.
  70. Treszl A, Szereday L, Doria A, King GL, Orban T. Elevated C-reactive protein levels do not correspond to autoimmunity in type 1 diabetes. Diabetes Care. 2004 Nov; 27(11):2769-70.
    View in: PubMed
  71. Bacci S, Menzaghi C, Ercolino T, Ma X, Rauseo A, Salvemini L, Vigna C, Fanelli R, Di Mario U, Doria A, Trischitta V. The +276 G/T single nucleotide polymorphism of the adiponectin gene is associated with coronary artery disease in type 2 diabetic patients. Diabetes Care. 2004 Aug; 27(8):2015-20.
    View in: PubMed
  72. Ma X, Bacci S, Mlynarski W, Gottardo L, Soccio T, Menzaghi C, Iori E, Lager RA, Shroff AR, Gervino EV, Nesto RW, Johnstone MT, Abumrad NA, Avogaro A, Trischitta V, Doria A. A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. Hum Mol Genet. 2004 Oct 1; 13(19):2197-205.
    View in: PubMed
  73. Menzaghi C, Ercolino T, Salvemini L, Coco A, Kim SH, Fini G, Doria A, Trischitta V. Multigenic control of serum adiponectin levels: evidence for a role of the APM1 gene and a locus on 14q13. Physiol Genomics. 2004 Oct 4; 19(2):170-4.
    View in: PubMed
  74. Kim SH, Ma X, Weremowicz S, Ercolino T, Powers C, Mlynarski W, Bashan KA, Warram JH, Mychaleckyj J, Rich SS, Krolewski AS, Doria A. Identification of a locus for maturity-onset diabetes of the young on chromosome 8p23. Diabetes. 2004 May; 53(5):1375-84.
    View in: PubMed
  75. Doria A, Warram JH, Krolewski AS. Genetic Determinants of Late Diabetic Complications. Marso, P, Stern, DM, (eds.). Diabetes and Cardiovascular Disease. 2004; 111-32.
  76. Hu FB, Doria A, Li T, Meigs JB, Liu S, Memisoglu A, Hunter D, Manson JE. Genetic variation at the adiponectin locus and risk of type 2 diabetes in women. Diabetes. 2004 Jan; 53(1):209-13.
    View in: PubMed
  77. Treszl A, Szereday L, Doria A, King GL, Orban T. Elevated C-reactive protein levels do not correspond to autoimmunity in type 1 diabetes. Diabetes Care. 2004; 27:2769-70.
  78. Kim SH, Ma X, Klupa T, Powers C, Pezzolesi M, Warram JH, Rich SS, Krolewski AS, Doria A. Genetic modifiers of the age at diagnosis of diabetes (MODY3) in carriers of hepatocyte nuclear factor-1alpha mutations map to chromosomes 5p15, 9q22, and 14q24. Diabetes. 2003 Aug; 52(8):2182-6.
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  79. Doria A. Adipokine genes and the insulin resistance syndrome. Crepaldi, G, Tiengo, A, Avogaro, A, (eds.). The Metabolic Syndrome: Diabetes, Obesity, Hyperlipidemia & Hypertension. 2003; 63-71.
  80. Klupa T, Warram JH, Antonellis A, Pezzolesi M, Nam M, Malecki MT, Doria A, Rich SS, Krolewski AS. Determinants of the development of diabetes (maturity-onset diabetes of the young-3) in carriers of HNF-1alpha mutations: evidence for parent-of-origin effect. Diabetes Care. 2002 Dec; 25(12):2292-301.
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  81. Ma X, Warram JH, Trischitta V, Doria A. Genetic variants at the resistin locus and risk of type 2 diabetes in Caucasians. J Clin Endocrinol Metab. 2002 Sep; 87(9):4407-10.
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  82. Menzaghi C, Ercolino T, Di Paola R, Berg AH, Warram JH, Scherer PE, Trischitta V, Doria A. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes. 2002 Jul; 51(7):2306-12.
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  83. Menzaghi C, Plengvidhya N, Ma X, Warram JH, Shoelson SE, Doria A. Genetic variability in insulin action inhibitor Ikkbeta (IKBKB) does not play a major role in the development of type 2 diabetes. J Clin Endocrinol Metab. 2002 Apr; 87(4):1894-7.
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  84. Doria AS, Kiss MH, Lotito AP, Molnar LJ, de Castro CC, Medeiros CC, Cerri GG. Juvenile rheumatoid arthritis of the knee: evaluation with contrast-enhanced color Doppler ultrasound. Pediatr Radiol. 2001 Jul; 31(7):524-31.
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  85. Kim SH, Warram JH, Krolewski AS, Doria A. Mutation screening of the neurogenin-3 gene in autosomal dominant diabetes. J Clin Endocrinol Metab. 2001 May; 86(5):2320-2.
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  86. Almind K, Doria A, Kahn CR. Putting the genes for type II diabetes on the map. Nat Med. 2001 Mar; 7(3):277-9.
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  87. Bektas A, Hughes JN, Warram JH, Krolewski AS, Doria A. Type 2 diabetes locus on 12q15. Further mapping and mutation screening of two candidate genes. Diabetes. 2001 Jan; 50(1):204-8.
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  88. Doria AS, Guarniero R, Molnar LJ, Modena M, Cunha FG, de Godoy Jr RM, Cerri GG. Three-dimensional (3D) contrast-enhanced power Doppler imaging in Legg-Calvé-Perthes disease. Pediatr Radiol. 2000 Dec; 30(12):871-4.
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  89. Doria A. Methods for the study of the genetic determinants of diabetes and its complications. Przegl Lek. 2000; 57 Suppl 3:7-12.
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  90. Doria A, Plengvidhya N. Recent advances in the genetics of maturity onset diabetes of the young and other forms of autosomal dominant diabetes. Curr Opin Endocrinol Diabetes. 2000; 7:203-210.
  91. Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet. 1999 Nov; 23(3):323-8.
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  92. Bektas A, Suprenant ME, Wogan LT, Plengvidhya N, Rich SS, Warram JH, Krolewski AS, Doria A. Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q. Diabetes. 1999 Nov; 48(11):2246-51.
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  93. Plengvidhya N, Antonellis A, Wogan LT, Poleev A, Borgschulze M, Warram JH, Ryffel GU, Krolewski AS, Doria A. Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. Diabetes. 1999 Oct; 48(10):2099-102.
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  94. Ecklund K, Doria AS, Jaramillo D. Rickets on MR images. Pediatr Radiol. 1999 Sep; 29(9):673-5.
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  95. Bektas A, Warram JH, White MF, Krolewski AS, Doria A. Exclusion of insulin receptor substrate 2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes. Diabetes. 1999 Mar; 48(3):640-2.
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  96. Doria A, Yang Y, Malecki M, Scotti S, Dreyfus J, O'Keeffe C, Orban T, Warram JH, Krolewski AS. Phenotypic characteristics of early-onset autosomal-dominant type 2 diabetes unlinked to known maturity-onset diabetes of the young (MODY) genes. Diabetes Care. 1999 Feb; 22(2):253-61.
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  97. Moczulski DK, Burak W, Doria A, Zychma M, Zukowska-Szczechowska E, Warram JH, Grzeszczak W. The role of aldose reductase gene in the susceptibility to diabetic nephropathy in Type II (non-insulin-dependent) diabetes mellitus. Diabetologia. 1999 Jan; 42(1):94-7.
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  98. Ristow M, Giannakidou E, Hebinck J, Busch K, Vorgerd M, Kotzka J, Knebel B, Mueller-Berghaus J, Epplen C, Pfeiffer A, Kahn CR, Doria A, Krone W, Mueller-Wieland D. An association between NIDDM and a GAA trinucleotide repeat polymorphism in the X25/frataxin (Friedreich's ataxia) gene. Diabetes. 1998 May; 47(5):851-4.
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  99. Doria A. Genetic markers of increased susceptibility to diabetic nephropathy. Horm Res. 1998; 50 Suppl 1:6-11.
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  100. Doria A, Onuma T, Warram JH, Krolewski AS. Synergistic effect of angiotensin II type 1 receptor genotype and poor glycaemic control on risk of nephropathy in IDDM. Diabetologia. 1997 Nov; 40(11):1293-9.
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  101. Doria AS, Taylor GA. Bony involvement in paracoccidioidomycosis. Pediatr Radiol. 1997 Jan; 27(1):67-9.
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  102. Caldwell JS, Moyers JS, Doria A, Reynet C, Kahn RC. Molecular cloning of the human rad gene: gene structure and complete nucleotide sequence. Biochim Biophys Acta. 1996 Aug 23; 1316(3):145-8.
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  103. Doria A, Lee J, Warram JH, Krolewski AS. Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene. Diabetologia. 1996 May; 39(5):594-9.
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  104. Doria A, Onuma T, Gearin G, Freire MB, Warram JH, Krolewski AS. Angiotensinogen polymorphism M235T, hypertension, and nephropathy in insulin-dependent diabetes. Hypertension. 1996 May; 27(5):1134-9.
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  105. Sigal RJ, Doria A, Warram JH, Krolewski AS. Codon 972 polymorphism in the insulin receptor substrate-1 gene, obesity, and risk of noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1996 Apr; 81(4):1657-9.
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  106. Kahn CR, Vicent D, Doria A. Genetics of non-insulin-dependent (type-II) diabetes mellitus. Annu Rev Med. 1996; 47:509-31.
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  107. Doria A, Warram JH, Krolewski AS. Genetic susceptibility to nephropathy in insulin-dependent diabetes: from epidemiology to molecular genetics. Diabetes Metab Rev. 1995 Dec; 11(4):287-314.
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  108. Zerbini G, Roth T, Podestá F, Cagliero E, Doria A, Canessa M, Lorenzi M. Activity and expression of the Na+/H+ exchanger in human endothelial cells cultured in high glucose. Diabetologia. 1995 Jul; 38(7):785-91.
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  109. Doria A, Caldwell JS, Ji L, Reynet C, Rich SS, Weremowicz S, Morton CC, Warram JH, Kahn CR, Krolewski AS. Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q. Diabetes. 1995 Feb; 44(2):243-7.
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  110. Doria A, Warram JH, Rich SS, Krolewski AS. Angiotensin I-converting enzyme (ACE): estimation of DNA haplotypes in unrelated individuals using denaturing gradient gel blots. Hum Genet. 1994 Aug; 94(2):117-23.
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  111. Doria A, Ji L, Warram JH, Krolewski AS. DdeI polymorphism in the AGTR1 gene. Hum Mol Genet. 1994 Aug; 3(8):1444.
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  112. Doria A, Warram JH, Krolewski AS. Genetic predisposition to diabetic nephropathy. Evidence for a role of the angiotensin I--converting enzyme gene. Diabetes. 1994 May; 43(5):690-5.
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  113. Doria A, Warram JH, Krolewski AS. Molecular characterization of a DDEI melting polymorphism at the angiotensin I-converting enzyme (ACE) locus. Hum Mutat. 1994; 4(2):155-7.
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  114. Doria A, Warram JH, Krolewski AS. Four RSAI restriction fragment melting polymorphisms in the region of the insulin receptor gene encoding for the alpha subunit. Clin Genet. 1993 Nov; 44(5):279-80.
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  115. Manzato E, Zambon A, Zambon S, Nosadini R, Doria A, Marin R, Crepaldi G. Lipoprotein compositional abnormalities in type 1 (insulin-dependent) diabetic patients. Acta Diabetol. 1993; 30(1):11-6.
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  116. Doria A. Role of the angiotensinogen and angiotensin-converting enzyme genes in the predisposition to diabetic nephropathy. 1993.
  117. Krolewski AS, Doria A, Magre J, Warram JH, Housman D. Molecular genetic approaches to the identification of genes involved in the development of nephropathy in insulin-dependent diabetes mellitus. J Am Soc Nephrol. 1992 Oct; 3(4 Suppl):S9-17.
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  118. Nosadini R, Cipollina MR, Solini A, Sambataro M, Morocutti A, Doria A, Fioretto P, Brocco E, Muollo B, Frigato F. Close relationship between microalbuminuria and insulin resistance in essential hypertension and non-insulin dependent diabetes mellitus. J Am Soc Nephrol. 1992 Oct; 3(4 Suppl):S56-63.
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  119. Avogaro A, Doria A, Gnudi L, Carraro A, Duner E, Brocco E, Tiengo A, Crepaldi G, Bier DM, Nosadini R. Forearm ketone body metabolism in normal and in insulin-dependent diabetic patients. Am J Physiol. 1992 Aug; 263(2 Pt 1):E261-7.
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  120. Trevisan R, Nosadini R, Fioretto P, Semplicini A, Donadon V, Doria A, Nicolosi G, Zanuttini D, Cipollina MR, Lusiani L, et al. Clustering of risk factors in hypertensive insulin-dependent diabetics with high sodium-lithium countertransport. Kidney Int. 1992 Apr; 41(4):855-61.
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  121. Doria A, Fioretto P, Avogaro A, Carraro A, Morocutti A, Trevisan R, Frigato F, Crepaldi G, Viberti G, Nosadini R. Insulin resistance is associated with high sodium-lithium countertransport in essential hypertension. Am J Physiol. 1991 Dec; 261(6 Pt 1):E684-91.
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  122. Avogaro A, Nosadini R, Doria A, Fioretto P, Velussi M, Vigorito C, Saccà L, Toffolo G, Cobelli C, Trevisan R, et al. Myocardial metabolism in insulin-deficient diabetic humans without coronary artery disease. Am J Physiol. 1990 Apr; 258(4 Pt 1):E606-18.
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  123. Fioretto P, Trevisan R, Valerio A, Avogaro A, Borsato M, Doria A, Semplicini A, Sacerdoti D, Jones S, Bognetti E, et al. Impaired renal response to a meat meal in insulin-dependent diabetes: role of glucagon and prostaglandins. Am J Physiol. 1990 Mar; 258(3 Pt 2):F675-83.
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  124. Avogaro A, Nosadini R, Bier DM, Cobelli C, Toffolo G, Doria A, Valerio A, Christopherson H. Ketone body kinetics in vivo using simultaneous administration of acetoacetate and 3-hydroxybutyrate labelled with stable isotopes. Acta Diabetol Lat. 1990 Jan-Mar; 27(1):41-51.
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  125. Nosadini R, Fioretto P, Sacerdoti D, Giorato C, Morocutti A, Doria A, Avogaro A, Trevisan R, De Dona` C, Faronato PP, Riva F, Mollo F, Donadon V, Velussi M, Mongillo A, Viberti GC . Prostaglandins and kidney function in normal man. Crepaldi, G, Tiengo, A, Enzi, G (eds.). Diabetes, obesity and hyperlipidemias. 1990; 4:409-16.
  126. Avogaro A, Nosadini R, Doria A, Valerio A, Gnudi L, Dorella M, Miola M, Tiengo A, Cryer PE, Crepaldi G, Bier DM . Euglycemic type I insulin-dependent diabetic subjects have normal ketogenic epinephrine responsiveness. Crepaldi, G, Tiengo, A, Enzi, G (eds.). Diabetes, obesity and hyperlipidemias. 1990; 4:289-92.
  127. Avogaro A, Nosadini R, Doria A, Tremolada C, Baccaglini U, Ambrosio F, Merkel C, Nosadini A, Trevisan R, Fioretto P. Substrate availability other than glucose in the brain during euglycemia and insulin-induced hypoglycemia in dogs. Metabolism. 1990 Jan; 39(1):46-50.
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  128. Semplicini A, Angeli P, Nosadini R, Trevisan R, Fioretto P, Doria A, Rigon E, Sama B. Tubular Na+ handling in type I insulin-dependent diabetics during saline and ketone body infusion. Diabetes Res. 1989 Jun; 11(2):67-72.
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  129. Nosadini R, Avogaro A, Doria A, Fioretto P, Trevisan R, Morocutti A. Ketone body metabolism: a physiological and clinical overview. Diabetes Metab Rev. 1989 May; 5(3):299-319.
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  130. Zambon S, Zambon A, Nosadini R, Doria A, Marin R, Manzato E, Crepaldi G. . Lipids, lipoproteins and apoproteins in subject with type 1 diabetes treated with continuous subcutaneous insulin infusion. Descovich, GC, et al. (eds.). Atherosclerosis and cardiovascular disease. 1989; 4:not available.
  131. Nosadini R, Fioretto P, Giorato C, Morocutti A, Doria A, Zanette G, Donadon V, Dorella M, Crepaldi G. Sodium metabolism in insulin dependent diabetic patients. Role of insulin and atrial natriuretic peptide. Diabete Metab. 1989; 15(5 Pt 2):301-5.
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  132. Rigotti P, Ferraresso M, Spanio S, Furnari M, Doria A, Cecchetto A, Ancona A. Use of defibrotide in preventing vascular thrombosis in experimental pancreas transplantation. Surg Res Comm. 1989; 6:123-30.
  133. Nosadini R, Trevisan R, Fioretto P, Semplicini A, Sama` B, Velussi M, Da Campo GL, Avogaro A, Vizzaccaro A, Donadon V, Mongillo S, Doria A. Kidney hemodynamics after ketone body and aminoacid infusion in normal and IDDM subjects. Diabetes. 1989; 38:75-83.
  134. Nosadini R, De Kreutzenberg S, Duner E, Iori E, Avogaro A, Trevisan R, Fioretto P, Doria A, Merkel C, Cobelli C, et al. Porcine and human insulin absorption from subcutaneous tissues in normal and insulin-dependent diabetic subjects: a deconvolution-based approach. J Clin Endocrinol Metab. 1988 Sep; 67(3):551-9.
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  135. Nosadini R, Velussi M, Fioretto P, Doria A, Avogaro A, Trevisan R, Valerio A., Vizzaccaro A, Bruscagnin A., Cernigoi A, Pascoletti R, Bernardi G, Duner E, Da Campo GL, Costella GB. . Frequency of hypoglycemic and hyper glycemic-ketotic episodes during conventional and subcutaneous continuous insulin infusion therapy in IDDM. Diab Nutr Metab. 1988; 1:289-96.
  136. Fioretto P, Trevisan R, Giorato C, De Riva C, Doria A, Valerio A, Semplicini A, Angeli P, Cipollina MR, Nosadini R. Type I insulin-dependent diabetic patients show an impaired renal hemodynamic response to protein intake. J Diabet Complications. 1988 Jan-Mar; 2(1):27-9.
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  137. Doria A. Diabetic cardiopathy: studies of heart metabolism in IDDM individuals by means of stable and radioactive tracers. 1988.
  138. Nosadini R, Angelini C, Trevisan C, Vigili de Kreutzenberg S, Fioretto P, Trevisan R, Avogaro A, De Dona C, Doria A, Cobelli C, et al. Glucose and ketone body turnover in carnitine-palmitoyl-transferase deficiency. Metabolism. 1987 Sep; 36(9):821-6.
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  139. Trevisan R, Nosadini R, Fioretto P, Velussi M, Avogaro A, Duner E, Iori E, Doria A, Merkel C, Valerio A, et al. Metabolic control of kidney hemodynamics in normal and insulin-dependent diabetic subjects. Effects of acetoacetic, lactic, and acetic acids. Diabetes. 1987 Sep; 36(9):1073-81.
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  140. Fioretto P, Trevisan R, Velussi M, Cernigoi A, De Riva C, Bressan M, Doria A, Pauletto N, Angeli P, De Donà C, et al. Glomerular filtration rate is increased in man by the infusion of both D,L-3-hydroxybutyric acid and sodium D,L-3-hydroxybutyrate. J Clin Endocrinol Metab. 1987 Aug; 65(2):331-8.
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  141. Trevisan R, Nosadini R, Fioretto P, Avogaro A, Duner E, Jori E, Valerio A, Doria A, Crepaldi G. Ketone bodies increase glomerular filtration rate in normal man and in patients with type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1987 Apr; 30(4):214-21.
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  142. Doria A. Insulin sensitivity, pancreatic secretion, and receptor binding in normal individuals of different age. 1985.
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