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Galina K. Sukhova, PH.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Cardiovascular Division, NRB-730J
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-4354
Fax617/525-4380

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhang J, Chen H, Liu L, Sun J, Shi MA, Sukhova GK, Shi GP. Chemokine (C-C motif) receptor 2 mediates mast cell migration to abdominal aortic aneurysm lesions in mice. Cardiovasc Res. 2012 Dec 1; 96(3):543-51.
    View in: PubMed
  2. Vasic D, Marx N, Sukhova G, Bach H, Durst R, Grüb M, Hausauer A, Hombach V, Rottbauer W, Walcher D. C-peptide promotes lesion development in a mouse model of arteriosclerosis. J Cell Mol Med. 2012 Apr; 16(4):927-35.
    View in: PubMed
  3. Xia M, Guerra N, Sukhova GK, Yang K, Miller CK, Shi GP, Raulet DH, Xiong N. Immune activation resulting from NKG2D/ligand interaction promotes atherosclerosis. Circulation. 2011 Dec 20; 124(25):2933-43.
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  4. Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xiang M, Wang J, Peters C, Reinheckel T, Shi GP. Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2500-8.
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  5. Quillard T, Tesmenitsky Y, Croce K, Travers R, Shvartz E, Koskinas KC, Sukhova GK, Aikawa E, Aikawa M, Libby P. Selective inhibition of matrix metalloproteinase-13 increases collagen content of established mouse atherosclerosis. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2464-72.
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  6. Wang J, Cheng X, Xiang MX, Alanne-Kinnunen M, Wang JA, Chen H, He A, Sun X, Lin Y, Tang TT, Tu X, Sjöberg S, Sukhova GK, Liao YH, Conrad DH, Yu L, Kawakami T, Kovanen PT, Libby P, Shi GP. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest. 2011 Sep; 121(9):3564-77.
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  7. Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xia M, Xiong N, Gelb BD, Shi GP. Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2012 Jan; 32(1):15-23.
    View in: PubMed
  8. Folco EJ, Sheikine Y, Rocha VZ, Christen T, Shvartz E, Sukhova GK, Di Carli MF, Libby P. Hypoxia but not inflammation augments glucose uptake in human macrophages: Implications for imaging atherosclerosis with 18fluorine-labeled 2-deoxy-D-glucose positron emission tomography. J Am Coll Cardiol. 2011 Aug 2; 58(6):603-14.
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  9. Zhang J, Sun J, Lindholt JS, Sukhova GK, Sinnamon M, Stevens RL, Adachi R, Libby P, Thompson RW, Shi GP. Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation. Circ Res. 2011 May 27; 108(11):1316-27.
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  10. Chatzizisis YS, Baker AB, Sukhova GK, Koskinas KC, Papafaklis MI, Beigel R, Jonas M, Coskun AU, Stone BV, Maynard C, Shi GP, Libby P, Feldman CL, Edelman ER, Stone PH. Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs. Circulation. 2011 Feb 15; 123(6):621-30.
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  11. Tang EH, Shvartz E, Shimizu K, Rocha VZ, Zheng C, Fukuda D, Shi GP, Sukhova G, Libby P. Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):261-9.
    View in: PubMed
  12. Yu W, Liu J, Shi MA, Wang J, Xiang M, Kitamoto S, Wang B, Sukhova GK, Murphy GF, Orasanu G, Grubb A, Shi GP. Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice. PLoS One. 2010; 5(11):e13973.
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  13. Tang EH, Shimizu K, Christen T, Rocha VZ, Shvartz E, Tesmenitsky Y, Sukhova G, Shi GP, Libby P. Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions. Cardiovasc Res. 2011 Jan 1; 89(1):234-43.
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  14. Sun J, Hartvigsen K, Chou MY, Zhang Y, Sukhova GK, Zhang J, Lopez-Ilasaca M, Diehl CJ, Yakov N, Harats D, George J, Witztum JL, Libby P, Ploegh H, Shi GP. Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. Circulation. 2010 Aug 24; 122(8):808-20.
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  15. Schulte S, Sun J, Libby P, Macfarlane L, Sun C, Lopez-Ilasaca M, Shi GP, Sukhova GK. Cystatin C deficiency promotes inflammation in angiotensin II-induced abdominal aortic aneurisms in atherosclerotic mice. Am J Pathol. 2010 Jul; 177(1):456-63.
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  16. Sun J, Zhang J, Lindholt JS, Sukhova GK, Liu J, He A, Abrink M, Pejler G, Stevens RL, Thompson RW, Ennis TL, Gurish MF, Libby P, Shi GP. Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation. 2009 Sep 15; 120(11):973-82.
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  17. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009 Aug; 15(8):940-5.
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  18. Croce K, Gao H, Wang Y, Mooroka T, Sakuma M, Shi C, Sukhova GK, Packard RR, Hogg N, Libby P, Simon DI. Myeloid-related protein-8/14 is critical for the biological response to vascular injury. Circulation. 2009 Aug 4; 120(5):427-36.
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  19. Abramochkin DV, Kuzmin VS, Sukhova GS, Rosenshtraukh LV. Modulation of rabbit sinoatrial node activation sequence by acetylcholine and isoproterenol investigated with optical mapping technique. Acta Physiol (Oxf). 2009 Aug; 196(4):385-94.
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  20. Sukhova GK, Nozdrachev AD, Gozal D. [Neonatal intermittent hypoxia and hypertension]. Zh Evol Biokhim Fiziol. 2009 Mar-Apr; 45(2):202-7.
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  21. Wu G, Hu W, Shahsafaei A, Song W, Dobarro M, Sukhova GK, Bronson RR, Shi GP, Rother RP, Halperin JA, Qin X. Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. Circ Res. 2009 Feb 27; 104(4):550-8.
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  22. Rocha VZ, Folco EJ, Sukhova G, Shimizu K, Gotsman I, Vernon AH, Libby P. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res. 2008 Aug 29; 103(5):467-76.
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  23. Schulte S, Sukhova GK, Libby P. Genetically programmed biases in Th1 and Th2 immune responses modulate atherogenesis. Am J Pathol. 2008 Jun; 172(6):1500-8.
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  24. Schneider F, Sukhova GK, Aikawa M, Canner J, Gerdes N, Tang SM, Shi GP, Apte SS, Libby P. Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques. Circulation. 2008 Feb 19; 117(7):931-9.
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  25. Okamoto Y, Folco EJ, Minami M, Wara AK, Feinberg MW, Sukhova GK, Colvin RA, Kihara S, Funahashi T, Luster AD, Libby P. Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res. 2008 Feb 1; 102(2):218-25.
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  26. Sun J, Sukhova GK, Yang M, Wolters PJ, MacFarlane LA, Libby P, Sun C, Zhang Y, Liu J, Ennis TL, Knispel R, Xiong W, Thompson RW, Baxter BT, Shi GP. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest. 2007 Nov; 117(11):3359-68.
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  27. Gotsman I, Grabie N, Dacosta R, Sukhova G, Sharpe A, Lichtman AH. Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice. J Clin Invest. 2007 Oct; 117(10):2974-82.
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  28. Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol. 2007 Aug; 9(8):970-7.
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  29. Sun J, Sukhova GK, Wolters PJ, Yang M, Kitamoto S, Libby P, MacFarlane LA, Mallen-St Clair J, Shi GP. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med. 2007 Jun; 13(6):719-24.
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  30. Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D, Cantley LC. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc Natl Acad Sci U S A. 2007 May 8; 104(19):8077-82.
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  31. Kitamoto S, Sukhova GK, Sun J, Yang M, Libby P, Love V, Duramad P, Sun C, Zhang Y, Yang X, Peters C, Shi GP. Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. Circulation. 2007 Apr 17; 115(15):2065-75.
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  32. Sukhova GK, Shi GP. Do cathepsins play a role in abdominal aortic aneurysm pathogenesis? Ann N Y Acad Sci. 2006 Nov; 1085:161-9.
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  33. Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 2006 Nov 7; 114(19):2047-55.
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  34. Ziouzenkova O, Orasanu G, Sukhova G, Lau E, Berger JP, Tang G, Krinsky NI, Dolnikowski GG, Plutzky J. Asymmetric cleavage of beta-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses. Mol Endocrinol. 2007 Jan; 21(1):77-88.
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  35. Takayama K, Sukhova GK, Chin MT, Libby P. A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling. Circ Res. 2006 Mar 3; 98(4):499-504.
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  36. Sukhova GK, Shi G-P. Do Cathepsins play a role in AAA pathogenesis?. Ann NY Acad Sci USA. 2006; 1085:161-169.
  37. Sales VL, Sukhova GK, Lopez-Ilasaca MA, Libby P, Dzau VJ, Pratt RE. Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. Circulation. 2005 Nov 22; 112(21):3328-36.
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  38. Liu J, Sukhova GK, Yang JT, Sun J, Ma L, Ren A, Xu WH, Fu H, Dolganov GM, Hu C, Libby P, Shi GP. Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. Atherosclerosis. 2006 Feb; 184(2):302-11.
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  39. Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res. 2005 Feb 18; 96(3):368-75.
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  40. Sukhova GK, Libby P. The macrophage and the atherosclerosis process. Atlas of Atherosclerosis; Risk Factors and Treatment. 2005; 21-31.
  41. Krettek A, Sukhova GK, Schönbeck U, Libby P. Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm: possible role for a feedback loop in endothelial cells. Am J Pathol. 2004 Nov; 165(5):1571-81.
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  42. Kaazempur-Mofrad MR, Isasi AG, Younis HF, Chan RC, Hinton DP, Sukhova G, LaMuraglia GM, Lee RT, Kamm RD. Characterization of the atherosclerotic carotid bifurcation using MRI, finite element modeling, and histology. Ann Biomed Eng. 2004 Jul; 32(7):932-46.
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  43. Pan JH, Sukhova GK, Yang JT, Wang B, Xie T, Fu H, Zhang Y, Satoskar AR, David JR, Metz CN, Bucala R, Fang K, Simon DI, Chapman HA, Libby P, Shi GP. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2004 Jun 29; 109(25):3149-53.
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  44. Liu J, Sukhova GK, Sun JS, Xu WH, Libby P, Shi GP. Lysosomal cysteine proteases in atherosclerosis. Arterioscler Thromb Vasc Biol. 2004 Aug; 24(8):1359-66.
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  45. Krettek A, Sukhova GK, Schönbeck U, Libby P. Enhanced expression of CD44 variants in human atheroma and abdominal aortic aneurysm. Am J Path. 2004; 165:1571-1581.
  46. Sukhova GK, Shi G-P, Libby P. Role of elastolytic cathepsins in vascular remodeling. Excerpta Medica International Congress Series. 2004; (Atherosclerosis XIII):498-501.
  47. Dollery CM, Owen CA, Sukhova GK, Krettek A, Shapiro SD, Libby P. Neutrophil elastase in human atherosclerotic plaques: production by macrophages. Circulation. 2003 Jun 10; 107(22):2829-36.
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  48. Sukhova GK, Zhang Y, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum JL, Lu ML, Sakara Y, Chin MT, Libby P, Shi GP. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003 Mar; 111(6):897-906.
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  49. Pan JH, Lindholt JS, Sukhova GK, Baugh JA, Henneberg EW, Bucala R, Donnelly SC, Libby P, Metz C, Shi GP. Macrophage migration inhibitory factor is associated with aneurysmal expansion. J Vasc Surg. 2003 Mar; 37(3):628-35.
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  50. Krettek A, Sukhova GK, Libby P. Elastogenesis in human arterial disease: a role for macrophages in disordered elastin synthesis. Arterioscler Thromb Vasc Biol. 2003 Apr 1; 23(4):582-7.
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  51. Shi GP, Sukhova GK, Kuzuya M, Ye Q, Du J, Zhang Y, Pan JH, Lu ML, Cheng XW, Iguchi A, Perrey S, Lee AM, Chapman HA, Libby P. Deficiency of the cysteine protease cathepsin S impairs microvessel growth. Circ Res. 2003 Mar 21; 92(5):493-500.
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  52. Sukhova GK, Zhang Y, Pan J-H, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum JL, Lu ML, Sakata Y, Chin MT, Libby P, Shi G-P . Deficiency of Cathepsin S reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. JCI. 2003; 111:897-906.
  53. Maron R, Sukhova G, Faria AM, Hoffmann E, Mach F, Libby P, Weiner HL. Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation. 2002 Sep 24; 106(13):1708-15.
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  54. Takayama K, García-Cardena G, Sukhova GK, Comander J, Gimbrone MA, Libby P. Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J Biol Chem. 2002 Nov 15; 277(46):44147-54.
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  55. Sukhova GK, Williams JK, Libby P. Statins reduce inflammation in atheroma of nonhuman primates independent of effects on serum cholesterol. Arterioscler Thromb Vasc Biol. 2002 Sep 1; 22(9):1452-8.
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  56. Schönbeck U, Sukhova GK, Gerdes N, Libby P. T(H)2 predominant immune responses prevail in human abdominal aortic aneurysm. Am J Pathol. 2002 Aug; 161(2):499-506.
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  57. Gerdes N, Sukhova GK, Libby P, Reynolds RS, Young JL, Schönbeck U. Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis. J Exp Med. 2002 Jan 21; 195(2):245-57.
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  58. Mach F, Sukhova GK, Michetti M, Libby P, Michetti P. Influence of Helicobacter pylori infection during atherogenesis in vivo in mice. Circ Res. 2002 Jan 11; 90(1):E1-4.
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  59. Mach F, Sukhova GK, Michetti M, Libby P, Michetti P. Influence of Helicobacter pylori infection during atherosclerosis in vitro in mice. Circ Res. 2002; 90(1):E1-E4.
  60. Schönbeck U, Sukhova GK*, Gerdes N, Libby P. Th2 predominant immune responses prevail in human abdominal aortic aneurysm. Am J Path. 2002; 161:499-506.
  61. Maron R, Sukhova GK, Faria AM, Hoffmann E, Mach F, Libby P, Weiner HL . Mucosal administration of HSP-65 decreases atherosclerosis and inflammation in the aortic arch of LDL receptor-deficient mice. Circulation. 2002; 106:1708-1715.
  62. Herman MP, Sukhova GK, Libby P, Gerdes N, Tang N, Horton DB, Kilbride M, Breitbart RE, Chun M, Schönbeck U. Expression of neutrophil collagenase (matrix metalloproteinase-8) in human atheroma: a novel collagenolytic pathway suggested by transcriptional profiling. Circulation. 2001 Oct 16; 104(16):1899-904.
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  63. Wassef M, Baxter BT, Chisholm RL, Dalman RL, Fillinger MF, Heinecke J, Humphrey JD, Kuivaniemi H, Parks WC, Pearce WH, Platsoucas CD, Sukhova GK, Thompson RW, Tilson MD, Zarins CK. Pathogenesis of abdominal aortic aneurysms: a multidisciplinary research program supported by the National Heart, Lung, and Blood Institute. J Vasc Surg. 2001 Oct; 34(4):730-8.
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  64. Herman MP, Sukhova GK, Kisiel W, Foster D, Kehry MR, Libby P, Schönbeck U. Tissue factor pathway inhibitor-2 is a novel inhibitor of matrix metalloproteinases with implications for atherosclerosis. J Clin Invest. 2001 May; 107(9):1117-26.
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  65. Sugiyama S, Okada Y, Sukhova GK, Virmani R, Heinecke JW, Libby P. Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes. Am J Pathol. 2001 Mar; 158(3):879-91.
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  66. Ignat'ev DA, Sukhova GS, Sukhov VP. [Analysis of changes in heart rate and temperature of the ground squirrel Citellus undulatus in various physiological states]. Zh Obshch Biol. 2001 Jan-Feb; 62(1):66-77.
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  67. Haley KJ, Lilly CM, Yang JH, Feng Y, Kennedy SP, Turi TG, Thompson JF, Sukhova GH, Libby P, Lee RT. Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation. Circulation. 2000 Oct 31; 102(18):2185-9.
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  68. Schönbeck U, Sukhova GK, Shimizu K, Mach F, Libby P. Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):7458-63.
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  69. Young JL, Sukhova GK, Foster D, Kisiel W, Libby P, Schönbeck U. The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells. J Exp Med. 2000 May 1; 191(9):1535-44.
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  70. Abi-Younes S, Sauty A, Mach F, Sukhova GK, Libby P, Luster AD. The stromal cell-derived factor-1 chemokine is a potent platelet agonist highly expressed in atherosclerotic plaques. Circ Res. 2000 Feb 4; 86(2):131-8.
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  71. Libby P, Aikawa M, Schönbeck U, Sukhova GK, Mach F, Marx N, Plutzky J . Inflammation and plaque stability. Excerpta Medica International Congress Series. 2000; (Atherosclerosis XII):67-80.
  72. Schönbeck U, Mach F, Sukhova GK, Herman M, Graber P, Kehry MR, Libby P. CD40 ligation induces tissue factor expression in human vascular smooth muscle cells. Am J Pathol. 2000 Jan; 156(1):7-14.
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  73. Schoenbeck U, Sukhova GK, Shimizu K, Mach F, Libby P. Inhibition of CD40 signalina limits evolution of established atherosclerosis in mice. Proc Natl Acad Sci USA. 2000; 97(13):7458-7463.
  74. Shi GP, Sukhova GK, Grubb A, Ducharme A, Rhode LH, Lee RT, Ridker PM, Libby P, Chapman HA. Cystatin C deficiency in human atherosclerosis and aortic aneurysms. J Clin Invest. 1999 Nov; 104(9):1191-7.
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  75. Mach F, Sauty A, Iarossi AS, Sukhova GK, Neote K, Libby P, Luster AD. Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells. J Clin Invest. 1999 Oct; 104(8):1041-50.
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  76. Schönbeck U, Sukhova GK, Graber P, Coulter S, Libby P. Augmented expression of cyclooxygenase-2 in human atherosclerotic lesions. Am J Pathol. 1999 Oct; 155(4):1281-91.
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  77. Melián A, Geng YJ, Sukhova GK, Libby P, Porcelli SA. CD1 expression in human atherosclerosis. A potential mechanism for T cell activation by foam cells. Am J Pathol. 1999 Sep; 155(3):775-86.
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  78. Marx N, Sukhova GK, Collins T, Libby P, Plutzky J. PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation. 1999 Jun 22; 99(24):3125-31.
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  79. Rohde LE, Ducharme A, Arroyo LH, Aikawa M, Sukhova GH, Lopez-Anaya A, McClure KF, Mitchell PG, Libby P, Lee RT. Matrix metalloproteinase inhibition attenuates early left ventricular enlargement after experimental myocardial infarction in mice. Circulation. 1999 Jun 15; 99(23):3063-70.
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  80. Sukhova GK, Schönbeck U, Rabkin E, Schoen FJ, Poole AR, Billinghurst RC, Libby P. Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques. Circulation. 1999 May 18; 99(19):2503-9.
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  81. Rohde LE, Aikawa M, Cheng GC, Sukhova G, Solomon SD, Libby P, Pfeffer J, Pfeffer MA, Lee RT. Echocardiography-derived left ventricular end-systolic regional wall stress and matrix remodeling after experimental myocardial infarction. J Am Coll Cardiol. 1999 Mar; 33(3):835-42.
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  82. Schönbeck U, Mach F, Sukhova GK, Atkinson E, Levesque E, Herman M, Graber P, Basset P, Libby P. Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro and in vivo. J Exp Med. 1999 Mar 1; 189(5):843-53.
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  83. Marx N, Bourcier T, Sukhova GK, Libby P, Plutzky J. PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. Arterioscler Thromb Vasc Biol. 1999 Mar; 19(3):546-51.
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  84. Schönbeck U, Mach F, Sukhova GK, Atkinson E, Levesque E, Herman M, Graber P, Basset P, Libby P. Expression of the unique matrix metalloproteinase stromelysin-3 in atherosclerotic lesions: regulation via CD40/CD40L-signaling in vitro and in vivo. J Exp Med. 1999; 189:1-11.
  85. Henderson EL, Geng YJ, Sukhova GK, Whittemore AD, Knox J, Libby P. Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms. Circulation. 1999 Jan 5-12; 99(1):96-104.
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  86. Fabunmi RP, Sukhova GK, Sugiyama S, Libby P. Expression of tissue inhibitor of metalloproteinases-3 in human atheroma and regulation in lesion-associated cells: a potential protective mechanism in plaque stability. Circ Res. 1998 Aug 10; 83(3):270-8.
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  87. Sukhova GK, Shi GP, Simon DI, Chapman HA, Libby P. Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells. J Clin Invest. 1998 Aug 1; 102(3):576-83.
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  88. Gu L, Okada Y, Clinton SK, Gerard C, Sukhova GK, Libby P, Rollins BJ. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell. 1998 Aug; 2(2):275-81.
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  89. Kol A, Sukhova GK, Lichtman AH, Libby P. Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation. 1998 Jul 28; 98(4):300-7.
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  90. Mach F, Schönbeck U, Sukhova GK, Atkinson E, Libby P. Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature. 1998 Jul 9; 394(6689):200-3.
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  91. Marx N, Sukhova G, Murphy C, Libby P, Plutzky J. Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro. Am J Pathol. 1998 Jul; 153(1):17-23.
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  92. Aikawa M, Rabkin E, Okada Y, Voglic SJ, Clinton SK, Brinckerhoff CE, Sukhova GK, Libby P. Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization. Circulation. 1998 Jun 23; 97(24):2433-44.
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  93. Williams JK, Sukhova GK, Herrington DM, Libby P. Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys. J Am Coll Cardiol. 1998 Mar 1; 31(3):684-91.
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  94. Williams JK, Sukhova GK, Herrington DM, Libby P. Pravastatin has cholesterol-lowering independent effects on the artery wall of atherosclerotic monkeys. J Am Coll. 1998; 31:684-691.
  95. Marx N, Sukhova GK, Murphy C, Libby P, Plutzky J. Macrophages in human atheroma contain PPARg: Differentiation-dependent PPARg expression and reduction of MMP-9 activity through PPARg activation in mononuclear phagocytes. Am J Path. 1998; 153:17-23.
  96. Fabunmi RP, Sukhova GK, Sugiyama S, Libby P. Expression of tissue inhibitor of metalloproteinases-3 in human atheroma and regulation in lesion-associated cells: a potential protective mechanism in plaque stability. Circ Res. 1998;83:270-278. 1998; 83:270-278.
  97. Libby P, Sukhova G, Lee RT, Liao JK. Molecular biology of atherosclerosis. Int J Cardiol. 1997 Dec 31; 62 Suppl 2:S23-9.
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  98. Schönbeck U, Mach F, Sukhova GK, Murphy C, Bonnefoy JY, Fabunmi RP, Libby P. Regulation of matrix metalloproteinase expression in human vascular smooth muscle cells by T lymphocytes: a role for CD40 signaling in plaque rupture? Circ Res. 1997 Sep; 81(3):448-54.
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  99. Bourcier T, Sukhova G, Libby P. The nuclear factor kappa-B signaling pathway participates in dysregulation of vascular smooth muscle cells in vitro and in human atherosclerosis. J Biol Chem. 1997 Jun 20; 272(25):15817-24.
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  100. Tanaka H, Sunamori M, Suzuki A, Sukhova GK, Libby P. Endothelial activation potentiates neointimal lesion formation in the rabbit aorta after balloon injury. Ann N Y Acad Sci. 1997 Apr 15; 811:448-58.
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  101. Libby P, Geng YJ, Sukhova GK, Simon DI, Lee RT. Molecular determinants of atherosclerotic plaque vulnerability. Ann N Y Acad Sci. 1997 Apr 15; 811:134-42; discussion 142-5.
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  102. Mach F, Schönbeck U, Sukhova GK, Bourcier T, Bonnefoy JY, Pober JS, Libby P. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis. Proc Natl Acad Sci U S A. 1997 Mar 4; 94(5):1931-6.
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  103. Knox JB, Sukhova GK, Whittemore AD, Libby P. Evidence for altered balance between matrix metalloproteinases and their inhibitors in human aortic diseases. Circulation. 1997 Jan 7; 95(1):205-12.
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  104. Libby P, Tanaka H, Kranzhöfer R, Sukhova GK, Allaire E, Clowes AW, Ganz P 1997:439-452. Inflammatory mechanisms of remodeling in injured arteries. Arterial remodeling: A critical factor in restenosis. 1997; 439-452.
  105. Mach F, Schönbeck U, Sukhova GK, Bourcier T, Bonnefoy J-Y, Pober JS, Libby P. Functional CD-40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis. Proc Natl Acad Sci USA. 1997; 94:1931-1936.
  106. Schönbeck U, Mach F, Sukhova GK, Bourcier T, Bonnefoy JY, Pober JS, Libby P . Expression of CD40 ligand on vascular wall cells: New pathway of immunological activation?. 1997.
  107. Libby P, Geng YJ, Aikawa M, Schoenbeck U, Mach F, Clinton SK, Sukhova GK, Lee RT. Macrophages and atherosclerotic plaque stability. Curr Opin Lipidol. 1996 Oct; 7(5):330-5.
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  108. Tanaka H, Sukhova G, Schwartz D, Libby P. Proliferating arterial smooth muscle cells after balloon injury express TNF-alpha but not interleukin-1 or basic fibroblast growth factor. Arterioscler Thromb Vasc Biol. 1996 Jan; 16(1):12-8.
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  109. Newman KD, Dunn PF, Owens JW, Schulick AH, Virmani R, Sukhova G, Libby P, Dichek DA. Adenovirus-mediated gene transfer into normal rabbit arteries results in prolonged vascular cell activation, inflammation, and neointimal hyperplasia. J Clin Invest. 1995 Dec; 96(6):2955-65.
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  110. Tanaka H, Swanson SJ, Sukhova G, Schoen FJ, Libby P. Smooth muscle cells of the coronary arterial tunica media express tumor necrosis factor-alpha and proliferate during acute rejection of rabbit cardiac allografts. Am J Pathol. 1995 Sep; 147(3):617-26.
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  111. Nakagawa T, Sukhova GK, Rabkin E, Winters GL, Schoen FJ, Libby P. Acute rejection accelerates graft coronary disease in transplanted rabbit hearts. Circulation. 1995 Aug 15; 92(4):987-93.
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  112. Galis ZS, Sukhova GK, Libby P. Microscopic localization of active proteases by in situ zymography: detection of matrix metalloproteinase activity in vascular tissue. FASEB J. 1995 Jul; 9(10):974-80.
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  113. Tanaka H, Swanson SJ, Sukhova G, Schoen FJ, Libby P. Early proliferation of medial smooth muscle cells in coronary arteries of rabbit cardiac allografts during immunosuppression with cyclosporine A. Transplant Proc. 1995 Jun; 27(3):2062-5.
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  114. Galis ZS, Muszynski M, Sukhova GK, Simon-Morrissey E, Libby P. Enhanced expression of vascular matrix metalloproteinases induced in vitro by cytokines and in regions of human atherosclerotic lesions. Ann N Y Acad Sci. 1995 Jan 17; 748:501-7.
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  115. Galis ZS, Sukhova GK, Kranzhöfer R, Clark S, Libby P. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases. Proc Natl Acad Sci U S A. 1995 Jan 17; 92(2):402-6.
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  116. Tanaka H, Suzuki A, Schwartz D, Sukhova G, Libby P. Activation of smooth muscle and endothelial cells following balloon injury. Ann N Y Acad Sci. 1995 Jan 17; 748:526-9.
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  117. Libby P, Sukhova G, Lee RT, Galis ZS. Cytokines regulate vascular functions related to stability of the atherosclerotic plaque. J Cardiovasc Pharmacol. 1995; 25 Suppl 2:S9-12.
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  118. Libby P, Sukhova GK, Brogi E, Schoen FJ, Tanaka H . Restenosis as an example of vascular hyperplastic disease: reassessment of potential mechanisms. Advances in Vascular Surgery. 1995; 79-90.
  119. Libby P, Sukhova GK, Kranzhöfer R, Tanaka H. Cellular activation in restenosis following angioplasty. Excerpta Medica International Congress Series. 1995; (Atherosclerosis X):690-693.
  120. Tanaka H , Swanson SJ, Sukhova GK, Schoen FJ, Libby P. Smooth muscle cells of the coronary arterial tunica media express tumor necrosis factor-a and proliferate during acute rejection of rabbit cardiac allografts. Am J Path. 1995; 147(3):617-626.
  121. Galis ZS, Sukhova GK, Lark MW, Libby P. Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest. 1994 Dec; 94(6):2493-503.
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  122. Galis ZS, Muszynski M, Sukhova GK, Simon-Morrissey E, Unemori EN, Lark MW, Amento E, Libby P. Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion. Circ Res. 1994 Jul; 75(1):181-9.
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  123. Tanaka H, Sukhova GK, Swanson SJ, Cybulsky MI, Schoen FJ, Libby P. Endothelial and smooth muscle cells express leukocyte adhesion molecules heterogeneously during acute rejection of rabbit cardiac allografts. Am J Pathol. 1994 May; 144(5):938-51.
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  124. Tanaka H, Sukhova GK, Libby P. Interaction of the allogeneic state and hypercholesterolemia in arterial lesion formation in experimental cardiac allografts. Arterioscler Thromb. 1994 May; 14(5):734-45.
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  125. Tanaka H, Sukhova GK, Swanson SJ, Cybulsky MI, Schoen FJ, Libby P. Vascular endothelial and smooth muscle cells express leukocyte adhesion molecules heterogeneously during acute rejection of cardiac allografts. Am J Path. 1994; 144(5):938-951.
  126. Tanaka H, Sukhova GK, Libby P. Iinteraction of the allogeneic state in hypercholesterolemia in arterial lesion formation in experimental cardiac allografts. Arteriosclerosis & Thrombosis. 1994; 14(5):734-745.
  127. Tanaka H, Sukhova GK, Swanson SJ, Clinton SK, Ganz P, Cybulsky MI, Libby P. Sustained activation of vascular cells and leukocytes in the rabbit aorta after balloon injury. Circulation. 1993 Oct; 88(4 Pt 1):1788-803.
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  128. Babaev VR, Bobryshev YV, Sukhova GK, Kasantseva IA. Monocyte/macrophage accumulation and smooth muscle cell phenotypes in early atherosclerotic lesions of human aorta. Atherosclerosis. 1993 May; 100(2):237-48.
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  129. Sukhova GK, Babaev VR, Sirotkin VN, Tararak Em. [Phenotype changes in smooth muscle cells of human coronary arteries during aging and during development of atherosclerosis]. Kardiologiia. 1991 Aug; 31(8):15-9.
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  130. Bobrishev Yu V, Sukhova GK, Babaev VP, Kazantseva IA. Contacts between cells in zones of early atherosclerotic lesions of human aorta. Arch Pathol. 1991; 53(11):38-42.
  131. Babaev VR, Sukhova GK, Bobrishev Yu.V, Sirotkin VN, Skorova NE, Tararak EM. Monocyte-macrophage infiltration in portions of atherosclerotic lesions of the human aorta. Arch Pathol. 1991; 53(10):48-53.
  132. Bobryshev IuV, Sukhova GK, Babaev VR, Kazantseva IA. [Intercellular contacts in portions of early atherosclerotic lesions of the human aorta]. Arkh Patol. 1991; 53(11):38-42.
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  133. Sukhova GK, Babaev VR, Sirotkin VN, Tararak EM. Modification of smooth muscle cells phenotypes in human coronary artery with age and atherosclerotic development. Cardiology. 1991; 31(8):15-19.
  134. Babaev VR, Sukhova GK, Bobryshev IuV, Sirotkin VN, Skorova NE, Tararak EM. [Monocyte-macrophage infiltration in portions of atherosclerotic lesions of the human aorta]. Arkh Patol. 1991; 53(10):48-53.
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  135. Sukhova GK, Nazaruk AV. [The ventilatory sensitivity of decerebrate vagotomized cats to CO2 after blockade of the trigeminal nerves]. Fiziol Zh SSSR Im I M Sechenova. 1990 May; 76(5):580-7.
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  136. Orekhov AN, Tertov VV, Mukhin DN, Koteliansky VE, Glukhova MA, Frid MG, Sukhova GK, Khashimov KA, Smirnov VN. Insolubilization of low density lipoprotein induces cholesterol accumulation in cultured subendothelial cells of human aorta. Atherosclerosis. 1989 Sep; 79(1):59-70.
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  137. Glebovskii VD, Sukhova GK, Nazaruk AV. [Effect of nasal breathing and blockade of the trigeminal nerves on the CO2 concentration in alveolar air in decerebrated cats]. Fiziol Zh SSSR Im I M Sechenova. 1988 Mar; 74(3):396-403.
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  138. Lebedev SP, Kovtun TI, Sukhova GK. Morphology and various problems of the pathogenesis of alcoholic microangiopathy. Arch Pathol. 1986; 48(10):26-33.
  139. Nikolaev AY, Kovtun TI, Lebedev SP, Proskurneva EP, Serov VV, Sukhova GK, Tareeva IE, Varshavsky VA, Vinogradova LG. Clinicomorphological features and prognosis of glomerulonephritus in chronic-alcoholism. Archiv of Therapy. 1986; 58(8):115-120.
  140. Lebedev SP, Kovtun TI, Sukhova GK. [Morphology and various problems of the pathogenesis of alcoholic microangiopathy]. Arkh Patol. 1986; 48(10):26-33.
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  141. Serov VV, Lebedev SP, Vinogradova LG, Mukhin AS, Sukhova GK. Intermediate filaments in lung macrophages and endothelial cells in patients with chronic alcoholism and purulent destructive pulmonary diseases. Bulletin of Experimental Biology & Medicine. 1985; 94:1733-1735.
  142. Lebedev SP, Vinogradova LG, Sukhova GK. [Alcoholic hyalin and interstitial filaments as markers of alcoholic damage of internal organs]. Arkh Patol. 1984; 46(11):52-8.
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  143. Lebedev SP, Makhov VM, Vinogradova LG, Sozinova TIu, Sukhova GK. [Morphology and morphogenesis of chronic gastritis in patients with alcoholism]. Arkh Patol. 1984; 46(2):44-50.
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  144. Lebedev SP, Machov VM, Vinogradova LG, Sozinova TI, Sukhova GK. Morphology and morphogenesis of chronic gastritis in patients with alcoholism. Arch Pathol. 1984; 46:44-50.
  145. Lebedev SP, Vinogradova LG, Sukhova GK. Alcoholic hyalin and interstitial filaments as markers of alcoholic damage of internal organs. Arch Pathol. 1984; 46(11):52-58.
  146. Glebovskii VD, Sukhova GK. [Effect of trigeminal nerve block on respiration in vagotomized cats]. Fiziol Zh SSSR Im I M Sechenova. 1983 Sep; 69(9):1207-15.
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  147. Serov VV, Lebedev SP, Vinogradova LG, Mukhin AS, Sukhova GK. [Intermediate filaments in the lung macrophages and endothelial cells in chronic alcoholism and suppurative-destructive lung diseases]. Biull Eksp Biol Med. 1982 Dec; 94(12):92-4.
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  148. Sukhova GK, Podrabinek TR, Kharlova GV. [Effect of regeneration of hematopoietic organs on the number and type of splenic colonies]. Biull Eksp Biol Med. 1978 Feb; 85(2):219-21.
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  149. Serov VV, Mukhin AS, Lebedev SP, Vinogradova LG, Sukhova GK. Morphological variants of alcoholic hyalin and possible ways of its evolution. Arch Pathol. 1978; 40(7):28-30.
  150. Serov VV, Mukhin AS, Lebedev SP, Vinogradova LG, Sukhova GK. [Morphological variants of alcoholic hyalin and possible ways of its evolution]. Arkh Patol. 1978; 40(7):28-34.
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  151. Sukhova GK, Podrabinek TR, Kharlova GV. Effect of regeneration of hemopoietic organs on the number and type of splenic colonies. Bulletin of Experimental Biology & Medicine. 1978; 85(2):223-225.
  152. Sukhova GK. Influence of regenerating hematopoietic organs stromal cells on a process of hematopoiesis in mice. 1978.
  153. Shubnikova EA, Pododina LS, Sukhova GK. [Electron microscopic study of the rat submaxillary gland during development]. Arkh Anat Gistol Embriol. 1976 Aug; 71(8):33-9.
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  154. Sukhova GK, Podrabinek TR, Kharlova GV. [Effect of spleen and bone marrow regeneration on the number of hematopoietic colonies in mouse spleen]. Biull Eksp Biol Med. 1976; 82(11):1375-6.
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  155. Sukhova GK, Podrabinek TR, Kharlova GV . Effect of spleen and bone marrow regeneration on the number of hemopoietic colonies in the mouse spleen. Bulletin of Experimental Biology & Medicine. 1976; 82(11):1720-1722.
  156. Shubnikova EA, Pogodina LS, Sukhova GK. Electron microscopic study of the rat submaxillary gland during development. Arch Anat Gistol Embriol. 1976; 71:33-39.
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