Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Susan Bonner-Weir, PH.D.

TitleProfessor of Medicine
InstitutionJoslin Diabetes Center
DepartmentMedicine
AddressJoslin Diabetes Center
Research Div., Rm 535
One Joslin Place
Boston MA 02215
Phone617/732-2581
Fax617/732-2650

 Mentoring 
 completed student projects
The Mechanisms of matrix Remodeling Around Duct Cells After Partial Pancreatectomy
Summer, 06/25/01 - 08/17/01

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Weir GC, Bonner-Weir S. Islet ß cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci. 2013 Apr; 1281(1):92-105.
    View in: PubMed
  2. Katsuta H, Aguayo-Mazzucato C, Katsuta R, Akashi T, Hollister-Lock J, Sharma AJ, Bonner-Weir S, Weir GC. Subpopulations of GFP-Marked Mouse Pancreatic ß-Cells Differ in Size, Granularity, and Insulin Secretion. Endocrinology. 2012 Nov; 153(11):5180-7.
    View in: PubMed
  3. Sarruf DA, Bonner-Weir S, Schwartz MW. New clues to bariatric surgery's benefits. Nat Med. 2012 Jun; 18(6):860-1.
    View in: PubMed
  4. Lysy PA, Weir GC, Bonner-Weir S. Concise review: pancreas regeneration: recent advances and perspectives. Stem Cells Transl Med. 2012 Feb; 1(2):150-9.
    View in: PubMed
  5. Weir GC, Cavelti-Weder C, Bonner-Weir S. Stem cell approaches for diabetes: towards beta cell replacement. Genome Med. 2011; 3(9):61.
    View in: PubMed
  6. Weir GC, Bonner-Weir S. Finally! A human pancreatic ß cell line. J Clin Invest. 2011 Sep; 121(9):3395-7.
    View in: PubMed
  7. Weir GC, Bonner-Weir S. Sleeping islets and the relationship between ß-cell mass and function. Diabetes. 2011 Aug; 60(8):2018-9.
    View in: PubMed
  8. Marsili A, Aguayo-Mazzucato C, Chen T, Kumar A, Chung M, Lunsford EP, Harney JW, Van-Tran T, Gianetti E, Ramadan W, Chou C, Bonner-Weir S, Larsen PR, Silva JE, Zavacki AM. Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity. PLoS One. 2011; 6(6):e20832.
    View in: PubMed
  9. Johnson AS, O'Sullivan E, D'Aoust LN, Omer A, Bonner-Weir S, Fisher RJ, Weir GC, Colton CK. Quantitative assessment of islets of Langerhans encapsulated in alginate. Tissue Eng Part C Methods. 2011 Apr; 17(4):435-49.
    View in: PubMed
  10. Jermendy A, Toschi E, Aye T, Koh A, Aguayo-Mazzucato C, Sharma A, Weir GC, Sgroi D, Bonner-Weir S. Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells. Diabetologia. 2011 Mar; 54(3):594-604.
    View in: PubMed
  11. Aguayo-Mazzucato C, Koh A, El Khattabi I, Li WC, Toschi E, Jermendy A, Juhl K, Mao K, Weir GC, Sharma A, Bonner-Weir S. Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells. Diabetologia. 2011 Mar; 54(3):583-93.
    View in: PubMed
  12. Thorrez L, Laudadio I, Van Deun K, Quintens R, Hendrickx N, Granvik M, Lemaire K, Schraenen A, Van Lommel L, Lehnert S, Aguayo-Mazzucato C, Cheng-Xue R, Gilon P, Van Mechelen I, Bonner-Weir S, Lemaigre F, Schuit F. Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation. Genome Res. 2011 Jan; 21(1):95-105.
    View in: PubMed
  13. Bonner-Weir S, Li WC, Ouziel-Yahalom L, Guo L, Weir GC, Sharma A. Beta-cell growth and regeneration: replication is only part of the story. Diabetes. 2010 Oct; 59(10):2340-8.
    View in: PubMed
  14. Hamamoto Y, Akashi T, Inada A, Bonner-Weir S, Weir GC. Lack of evidence for recipient precursor cells replenishing ß-cells in transplanted islets. Cell Transplant. 2010; 19(12):1563-72.
    View in: PubMed
  15. Keenan HA, Sun JK, Levine J, Doria A, Aiello LP, Eisenbarth G, Bonner-Weir S, King GL. Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes. 2010 Nov; 59(11):2846-53.
    View in: PubMed
  16. Pisania A, Papas KK, Powers DE, Rappel MJ, Omer A, Bonner-Weir S, Weir GC, Colton CK. Enumeration of islets by nuclei counting and light microscopic analysis. Lab Invest. 2010 Nov; 90(11):1676-86.
    View in: PubMed
  17. Pisania A, Weir GC, O'Neil JJ, Omer A, Tchipashvili V, Lei J, Colton CK, Bonner-Weir S. Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab Invest. 2010 Nov; 90(11):1661-75.
    View in: PubMed
  18. Li WC, Rukstalis JM, Nishimura W, Tchipashvili V, Habener JF, Sharma A, Bonner-Weir S. Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci. 2010 Aug 15; 123(Pt 16):2792-802.
    View in: PubMed
  19. Marselli L, Thorne J, Dahiya S, Sgroi DC, Sharma A, Bonner-Weir S, Marchetti P, Weir GC. Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One. 2010; 5(7):e11499.
    View in: PubMed
  20. Weir GC, Bonner-Weir S. Dreams for type 1 diabetes: shutting off autoimmunity and stimulating beta-cell regeneration. Endocrinology. 2010 Jul; 151(7):2971-3.
    View in: PubMed
  21. Kennedy J, Katsuta H, Jung MH, Marselli L, Goldfine AB, Balis UJ, Sgroi D, Bonner-Weir S, Weir GC. Protective unfolded protein response in human pancreatic beta cells transplanted into mice. PLoS One. 2010; 5(6):e11211.
    View in: PubMed
  22. Powers DE, Millman JR, Bonner-Weir S, Rappel MJ, Colton CK. Accurate control of oxygen level in cells during culture on silicone rubber membranes with application to stem cell differentiation. Biotechnol Prog. 2010 May-Jun; 26(3):805-18.
    View in: PubMed
  23. Aguayo-Mazzucato C, Bonner-Weir S. Stem cell therapy for type 1 diabetes mellitus. Nat Rev Endocrinol. 2010 Mar; 6(3):139-48.
    View in: PubMed
  24. Juhl K, Bonner-Weir S, Sharma A. Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis. Curr Opin Organ Transplant. 2010 Feb; 15(1):79-85.
    View in: PubMed
  25. O'Sullivan ES, Johnson AS, Omer A, Hollister-Lock J, Bonner-Weir S, Colton CK, Weir GC. Rat islet cell aggregates are superior to islets for transplantation in microcapsules. Diabetologia. 2010 May; 53(5):937-45.
    View in: PubMed
  26. Gianani R, Campbell-Thompson M, Sarkar SA, Wasserfall C, Pugliese A, Solis JM, Kent SC, Hering BJ, West E, Steck A, Bonner-Weir S, Atkinson MA, Coppieters K, von Herrath M, Eisenbarth GS. Dimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia. 2010 Apr; 53(4):690-8.
    View in: PubMed
  27. Aye T, Toschi E, Sharma A, Sgroi D, Bonner-Weir S. Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity. J Histochem Cytochem. 2010 Apr; 58(4):369-76.
    View in: PubMed
  28. Kushner JA, Weir GC, Bonner-Weir S. Ductal origin hypothesis of pancreatic regeneration under attack. Cell Metab. 2010 Jan; 11(1):2-3.
    View in: PubMed
  29. Weir GC, Marselli L, Marchetti P, Katsuta H, Jung MH, Bonner-Weir S. Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes. Diabetes Obes Metab. 2009 Nov; 11 Suppl 4:82-90.
    View in: PubMed
  30. Vetere A, Li WC, Paroni F, Juhl K, Guo L, Nishimura W, Dai X, Bonner-Weir S, Sharma A. OVO homologue-like 1 (Ovol1) transcription factor: a novel target of neurogenin-3 in rodent pancreas. Diabetologia. 2010 Jan; 53(1):115-22.
    View in: PubMed
  31. Katsuta H, Akashi T, Katsuta R, Nagaya M, Kim D, Arinobu Y, Hara M, Bonner-Weir S, Sharma AJ, Akashi K, Weir GC. Single pancreatic beta cells co-express multiple islet hormone genes in mice. Diabetologia. 2010 Jan; 53(1):128-38.
    View in: PubMed
  32. Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14460-5.
    View in: PubMed
  33. Nishimura W, Bonner-Weir S, Sharma A. Expression of MafA in pancreatic progenitors is detrimental for pancreatic development. Dev Biol. 2009 Sep 1; 333(1):108-20.
    View in: PubMed
  34. Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 2009 Aug; 23(8):1281-90.
    View in: PubMed
  35. Kikugawa R, Katsuta H, Akashi T, Yatoh S, Weir GC, Sharma A, Bonner-Weir S. Differentiation of COPAS-sorted non-endocrine pancreatic cells into insulin-positive cells in the mouse. Diabetologia. 2009 Apr; 52(4):645-52.
    View in: PubMed
  36. Nagaya M, Katsuta H, Kaneto H, Bonner-Weir S, Weir GC. Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells. J Endocrinol. 2009 Apr; 201(1):37-47.
    View in: PubMed
  37. Emamaullee JA, Merani S, Toso C, Kin T, Al-Saif F, Truong W, Pawlick R, Davis J, Edgar R, Lock J, Bonner-Weir S, Knudsen LB, Shapiro AM. Porcine marginal mass islet autografts resist metabolic failure over time and are enhanced by early treatment with liraglutide. Endocrinology. 2009 May; 150(5):2145-52.
    View in: PubMed
  38. Marselli L, Sgroi DC, Bonner-Weir S, Weir GC. Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling. Methods Mol Biol. 2009; 560:87-98.
    View in: PubMed
  39. Inada A, Nienaber C, Katsuta H, Fujitani Y, Levine J, Morita R, Sharma A, Bonner-Weir S. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19915-9.
    View in: PubMed
  40. Dodge R, Loomans C, Sharma A, Bonner-Weir S. Developmental pathways during in vitro progression of human islet neogenesis. Differentiation. 2009 Feb; 77(2):135-47.
    View in: PubMed
  41. Bonner-Weir S, O'Brien TD. Islets in type 2 diabetes: in honor of Dr. Robert C. Turner. Diabetes. 2008 Nov; 57(11):2899-904.
    View in: PubMed
  42. Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H, Flier JS, Strom TB. Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16242-7.
    View in: PubMed
  43. Akashi T, Shigematsu H, Hamamoto Y, Iwasaki H, Yatoh S, Bonner-Weir S, Akashi K, Weir GC. Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice. Diabetes Metab Res Rev. 2008 Oct; 24(7):585-90.
    View in: PubMed
  44. Larade K, Jiang Z, Zhang Y, Wang W, Bonner-Weir S, Zhu H, Bunn HF. Loss of Ncb5or results in impaired fatty acid desaturation, lipoatrophy, and diabetes. J Biol Chem. 2008 Oct 24; 283(43):29285-91.
    View in: PubMed
  45. Bonner-Weir S, Inada A, Yatoh S, Li WC, Aye T, Toschi E, Sharma A. Transdifferentiation of pancreatic ductal cells to endocrine beta-cells. Biochem Soc Trans. 2008 Jun; 36(Pt 3):353-6.
    View in: PubMed
  46. de Koning EJ, Bonner-Weir S, Rabelink TJ. Preservation of beta-cell function by targeting beta-cell mass. Trends Pharmacol Sci. 2008 Apr; 29(4):218-27.
    View in: PubMed
  47. Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM, Sharma A. Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol. 2008 Feb 15; 314(2):443-56.
    View in: PubMed
  48. Marselli L, Thorne J, Ahn YB, Omer A, Sgroi DC, Libermann T, Otu HH, Sharma A, Bonner-Weir S, Weir GC. Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab. 2008 Mar; 93(3):1046-53.
    View in: PubMed
  49. Koulmanda M, Budo E, Bonner-Weir S, Qipo A, Putheti P, Degauque N, Shi H, Fan Z, Flier JS, Auchincloss H, Zheng XX, Strom TB. Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A. 2007 Aug 7; 104(32):13074-9.
    View in: PubMed
  50. Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GC. Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats. Diabetologia. 2007 Oct; 50(10):2117-25.
    View in: PubMed
  51. King AJ, Fernandes JR, Hollister-Lock J, Nienaber CE, Bonner-Weir S, Weir GC. Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation. Diabetes. 2007 Sep; 56(9):2312-8.
    View in: PubMed
  52. Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem. 2007 Aug 17; 282(33):23829-40.
    View in: PubMed
  53. Yatoh S, Dodge R, Akashi T, Omer A, Sharma A, Weir GC, Bonner-Weir S. Differentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes. 2007 Jul; 56(7):1802-9.
    View in: PubMed
  54. Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007 Jun; 56(6):1551-8.
    View in: PubMed
  55. Yatoh S, Akashi T, Chan PP, Kaneto H, Sharma A, Bonner-Weir S, Weir GC. NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes. Diabetes Metab Res Rev. 2007 Mar; 23(3):239-49.
    View in: PubMed
  56. Weir GC, Bonner-Weir S. A dominant role for glucose in beta cell compensation of insulin resistance. J Clin Invest. 2007 Jan; 117(1):81-3.
    View in: PubMed
  57. Ahn YB, Xu G, Marselli L, Toschi E, Sharma A, Bonner-Weir S, Sgroi DC, Weir GC. Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection. Diabetologia. 2007 Feb; 50(2):334-42.
    View in: PubMed
  58. Krishnamurthy J, Ramsey MR, Ligon KL, Torrice C, Koh A, Bonner-Weir S, Sharpless NE. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature. 2006 Sep 28; 443(7110):453-7.
    View in: PubMed
  59. Evgenov NV, Medarova Z, Pratt J, Pantazopoulos P, Leyting S, Bonner-Weir S, Moore A. In vivo imaging of immune rejection in transplanted pancreatic islets. Diabetes. 2006 Sep; 55(9):2419-28.
    View in: PubMed
  60. Inada A, Nienaber C, Fonseca S, Bonner-Weir S. Timing and expression pattern of carbonic anhydrase II in pancreas. Dev Dyn. 2006 Jun; 235(6):1571-7.
    View in: PubMed
  61. Bonner-Weir S, Sharma A. Are there pancreatic progenitor cells from which new islets form after birth? Nat Clin Pract Endocrinol Metab. 2006 May; 2(5):240-1.
    View in: PubMed
  62. López-Avalos MD, Duvivier-Kali VF, Xu G, Bonner-Weir S, Sharma A, Weir GC. Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets. Diabetes. 2006 May; 55(5):1223-31.
    View in: PubMed
  63. Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S, Sharma A. A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol. 2006 May 15; 293(2):526-39.
    View in: PubMed
  64. Inada A, Bonner-Weir S, Toschi E. How can we get more beta cells? Curr Diab Rep. 2006 Apr; 6(2):96-101.
    View in: PubMed
  65. Inada A, Nienaber C, Bonner-Weir S. Endogenous beta-galactosidase expression in murine pancreatic islets. Diabetologia. 2006 May; 49(5):1120-2.
    View in: PubMed
  66. Xu G, Kaneto H, Lopez-Avalos MD, Weir GC, Bonner-Weir S. GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts. Diabetes Res Clin Pract. 2006 Jul; 73(1):107-10.
    View in: PubMed
  67. Medarova Z, Evgenov NV, Dai G, Bonner-Weir S, Moore A. In vivo multimodal imaging of transplanted pancreatic islets. Nat Protoc. 2006; 1(1):429-35.
    View in: PubMed
  68. Noguchi H, Xu G, Matsumoto S, Kaneto H, Kobayashi N, Bonner-Weir S, Hayashi S. Induction of pancreatic stem/progenitor cells into insulin-producing cells by adenoviral-mediated gene transfer technology. Cell Transplant. 2006; 15(10):929-38.
    View in: PubMed
  69. Evgenov NV, Medarova Z, Dai G, Bonner-Weir S, Moore A. In vivo imaging of islet transplantation. Nat Med. 2006 Jan; 12(1):144-8.
    View in: PubMed
  70. Noguchi H, Bonner-Weir S, Wei FY, Matsushita M, Matsumoto S. BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Diabetes. 2005 Oct; 54(10):2859-66.
    View in: PubMed
  71. Patti ME, McMahon G, Mun EC, Bitton A, Holst JJ, Goldsmith J, Hanto DW, Callery M, Arky R, Nose V, Bonner-Weir S, Goldfine AB. Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia. 2005 Nov; 48(11):2236-40.
    View in: PubMed
  72. King A, Lock J, Xu G, Bonner-Weir S, Weir GC. Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment. Diabetologia. 2005 Oct; 48(10):2074-9.
    View in: PubMed
  73. Inada A, Nagai K, Arai H, Miyazaki J, Nomura K, Kanamori H, Toyokuni S, Yamada Y, Bonner-Weir S, Weir GC, Fukatsu A, Seino Y. Establishment of a diabetic mouse model with progressive diabetic nephropathy. Am J Pathol. 2005 Aug; 167(2):327-36.
    View in: PubMed
  74. Bonner-Weir S, Weir GC. New sources of pancreatic beta-cells. Nat Biotechnol. 2005 Jul; 23(7):857-61.
    View in: PubMed
  75. Noguchi H, Matsushita M, Matsumoto S, Lu YF, Matsui H, Bonner-Weir S. Mechanism of PDX-1 protein transduction. Biochem Biophys Res Commun. 2005 Jun 24; 332(1):68-74.
    View in: PubMed
  76. Medarova Z, Bonner-Weir S, Lipes M, Moore A. Imaging beta-cell death with a near-infrared probe. Diabetes. 2005 Jun; 54(6):1780-8.
    View in: PubMed
  77. Inada A, Weir GC, Bonner-Weir S. Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells. Biochem Biophys Res Commun. 2005 Apr 15; 329(3):925-9.
    View in: PubMed
  78. Weir GC, Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes. 2004 Dec; 53 Suppl 3:S16-21.
    View in: PubMed
  79. Fernandes JR, Duvivier-Kali VF, Keegan M, Hollister-Lock J, Omer A, Su S, Bonner-Weir S, Feng S, Lee JS, Mulligan RC, Weir GC. Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors. Transpl Immunol. 2004 Nov; 13(3):191-200.
    View in: PubMed
  80. Weir GC, Bonner-Weir S. Beta-cell precursors--a work in progress. Nat Biotechnol. 2004 Sep; 22(9):1095-6.
    View in: PubMed
  81. Matsushita M, Noguchi H, Lu YF, Tomizawa K, Michiue H, Li ST, Hirose K, Bonner-Weir S, Matsui H. Photo-acceleration of protein release from endosome in the protein transduction system. FEBS Lett. 2004 Aug 13; 572(1-3):221-6.
    View in: PubMed
  82. Bonner-Weir S, Grodsky G. Assessment of human islet preparations to be used for islet expansion, survival, or transplant. Diabetes Technol Ther. 2004 Aug; 6(4):493-4.
    View in: PubMed
  83. Paty BW, Bonner-Weir S, Laughlin MR, McEwan AJ, Shapiro AM. Toward development of imaging modalities for islets after transplantation: insights from the National Institutes of Health Workshop on Beta Cell Imaging. Transplantation. 2004 Apr 27; 77(8):1133-7.
    View in: PubMed
  84. Inada A, Hamamoto Y, Tsuura Y, Miyazaki J, Toyokuni S, Ihara Y, Nagai K, Yamada Y, Bonner-Weir S, Seino Y. Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells. Mol Cell Biol. 2004 Apr; 24(7):2831-41.
    View in: PubMed
  85. Ko SH, Suh SH, Kim BJ, Ahn YB, Song KH, Yoo SJ, Son HS, Cha BY, Lee KW, Son HY, Kang SK, Bonner-Weir S, Weir GC, Yoon KH, Park CG. Expression of the intermediate filament vimentin in proliferating duct cells as a marker of pancreatic precursor cells. Pancreas. 2004 Mar; 28(2):121-8.
    View in: PubMed
  86. Bonner-Weir S, Toschi E, Inada A, Reitz P, Fonseca SY, Aye T, Sharma A. The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr Diabetes. 2004; 5 Suppl 2:16-22.
    View in: PubMed
  87. Makhlouf L, Duvivier-Kali VF, Bonner-Weir S, Dieperink H, Weir GC, Sayegh MH. Importance of hyperglycemia on the primary function of allogeneic islet transplants. Transplantation. 2003 Aug 27; 76(4):657-64.
    View in: PubMed
  88. Noguchi H, Kaneto H, Weir GC, Bonner-Weir S. PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells. Diabetes. 2003 Jul; 52(7):1732-7.
    View in: PubMed
  89. Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell. 2003 Jul; 5(1):73-83.
    View in: PubMed
  90. Omer A, Keegan M, Czismadia E, De Vos P, Van Rooijen N, Bonner-Weir S, Weir GC. Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. Xenotransplantation. 2003 May; 10(3):240-51.
    View in: PubMed
  91. Yoon KH, Ko SH, Cho JH, Lee JM, Ahn YB, Song KH, Yoo SJ, Kang MI, Cha BY, Lee KW, Son HY, Kang SK, Kim HS, Lee IK, Bonner-Weir S. Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab. 2003 May; 88(5):2300-8.
    View in: PubMed
  92. Tatarkiewicz K, López-Avalos MD, Yoon KH, Trivedi N, Quickel RR, Bonner-Weir S, Weir GC. Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture. Dev Growth Differ. 2003 Feb; 45(1):39-50.
    View in: PubMed
  93. Omer A, Duvivier-Kali VF, Trivedi N, Wilmot K, Bonner-Weir S, Weir GC. Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. Diabetes. 2003 Jan; 52(1):69-75.
    View in: PubMed
  94. Bonner-Weir S. Stem cells in diabetes: what has been achieved. Horm Res. 2003; 60 Suppl 3:10.
    View in: PubMed
  95. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003 Jan; 52(1):102-10.
    View in: PubMed
  96. Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, Bonner-Weir S, Weir GC. Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. J Biol Chem. 2003 Jan 31; 278(5):2997-3005.
    View in: PubMed
  97. Bonner-Weir S, Sharma A. Pancreatic stem cells. J Pathol. 2002 Jul; 197(4):519-26.
    View in: PubMed
  98. Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S. Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. Diabetes. 2002 Jun; 51(6):1793-804.
    View in: PubMed
  99. Wolpert HA, Faradji RN, Bonner-Weir S, Lipes MA. Metabolic decompensation in pump users due to lispro insulin precipitation. BMJ. 2002 May 25; 324(7348):1253.
    View in: PubMed
  100. Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GC. Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem. 2002 Aug 16; 277(33):30010-8.
    View in: PubMed
  101. Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas JC, Sgroi DC, Groff A, Ferran C, Bonner-Weir S, Sharma A, Weir GC. Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes. 2002 Feb; 51(2):413-23.
    View in: PubMed
  102. Kaneto H, Sharma A, Suzuma K, Laybutt DR, Xu G, Bonner-Weir S, Weir GC. Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. J Biol Chem. 2002 Apr 12; 277(15):12998-3006.
    View in: PubMed
  103. Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC. Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J Biol Chem. 2002 Mar 29; 277(13):10912-21.
    View in: PubMed
  104. Kaneto H, Suzuma K, Sharma A, Bonner-Weir S, King GL, Weir GC. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem. 2002 Feb 1; 277(5):3680-5.
    View in: PubMed
  105. Papas KK, Colton CK, Gounarides JS, Roos ES, Jarema MA, Shapiro MJ, Cheng LL, Cline GW, Shulman GI, Wu H, Bonner-Weir S, Weir GC. NMR spectroscopy in beta cell engineering and islet transplantation. Ann N Y Acad Sci. 2001 Nov; 944:96-119.
    View in: PubMed
  106. Orban T, Landaker E, Ruan Z, Cordeman TP, Weitgasser R, Bonner-Weir S, Jackson RA, Patti ME. High-fructose diet preserves beta-cell mass and prevents diabetes in nonobese diabetic mice: A potential role for increased insulin receptor substrate-2 expression. Metabolism. 2001 Nov; 50(11):1369-76.
    View in: PubMed
  107. Moore A, Bonner-Weir S, Weissleder R. Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes. Diabetes. 2001 Oct; 50(10):2231-6.
    View in: PubMed
  108. Tatarkiewicz K, Garcia M, Lopez-Avalos M, Bonner-Weir S, Weir GC. Porcine neonatal pancreatic cell clusters in tissue culture: benefits of serum and immobilization in alginate hydrogel. Transplantation. 2001 Jun 15; 71(11):1518-26.
    View in: PubMed
  109. Kaneto H, Xu G, Song KH, Suzuma K, Bonner-Weir S, Sharma A, Weir GC. Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress. J Biol Chem. 2001 Aug 17; 276(33):31099-104.
    View in: PubMed
  110. Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell. 2001 Jun; 7(6):1165-76.
    View in: PubMed
  111. Trivedi N, Hollister-Lock J, Lopez-Avalos MD, O'Neil JJ, Keegan M, Bonner-Weir S, Weir GC. Increase in beta-cell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of beta-cells and differentiation of duct cells. Endocrinology. 2001 May; 142(5):2115-22.
    View in: PubMed
  112. Steil GM, Trivedi N, Jonas JC, Hasenkamp WM, Sharma A, Bonner-Weir S, Weir GC. Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression. Am J Physiol Endocrinol Metab. 2001 May; 280(5):E788-96.
    View in: PubMed
  113. Lopez-Avalos MD, Tatarkiewicz K, Sharma A, Bonner-Weir S, Weir GC. Enhanced maturation of porcine neonatal pancreatic cell clusters with growth factors fails to improve transplantation outcome. Transplantation. 2001 Apr 27; 71(8):1154-62.
    View in: PubMed
  114. Vasir B, Jonas JC, Steil GM, Hollister-Lock J, Hasenkamp W, Sharma A, Bonner-Weir S, Weir GC. Gene expression of VEGF and its receptors Flk-1/KDR and Flt-1 in cultured and transplanted rat islets. Transplantation. 2001 Apr 15; 71(7):924-35.
    View in: PubMed
  115. Laybutt R, Hasenkamp W, Groff A, Grey S, Jonas JC, Kaneto H, Sharma A, Bonner-Weir S, Weir G. beta-cell adaptation to hyperglycemia. Diabetes. 2001 Feb; 50 Suppl 1:S180-1.
    View in: PubMed
  116. Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma A. Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes. 2001 Feb; 50 Suppl 1:S154-9.
    View in: PubMed
  117. Bonner-Weir S. beta-cell turnover: its assessment and implications. Diabetes. 2001 Feb; 50 Suppl 1:S20-4.
    View in: PubMed
  118. Sharma A, Taneja M, Rietz P, Weitekamp J, Bonner-Weir S. Novel pancreatic precursor cell lines for studying beta-cell differentiation. Diabetes. 2001 Feb; 50 Suppl 1:S42-3.
    View in: PubMed
  119. Trivedi N, Keegan M, Steil GM, Hollister-Lock J, Hasenkamp WM, Colton CK, Bonner-Weir S, Weir GC. Islets in alginate macrobeads reverse diabetes despite minimal acute insulin secretory responses. Transplantation. 2001 Jan 27; 71(2):203-11.
    View in: PubMed
  120. Dutta S, Gannon M, Peers B, Wright C, Bonner-Weir S, Montminy M. PDX:PBX complexes are required for normal proliferation of pancreatic cells during development. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):1065-70.
    View in: PubMed
  121. Bonner-Weir S. Life and death of the pancreatic beta cells. Trends Endocrinol Metab. 2000 Nov; 11(9):375-8.
    View in: PubMed
  122. Uysal KT, Scheja L, Wiesbrock SM, Bonner-Weir S, Hotamisligil GS. Improved glucose and lipid metabolism in genetically obese mice lacking aP2. Endocrinology. 2000 Sep; 141(9):3388-96.
    View in: PubMed
  123. Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song KH, Sharma A, O'Neil JJ. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci U S A. 2000 Jul 5; 97(14):7999-8004.
    View in: PubMed
  124. Bonner-Weir S. Islet growth and development in the adult. J Mol Endocrinol. 2000 Jun; 24(3):297-302.
    View in: PubMed
  125. Bonner-Weir S. Perspective: Postnatal pancreatic beta cell growth. Endocrinology. 2000 Jun; 141(6):1926-9.
    View in: PubMed
  126. Vasir B, Reitz P, Xu G, Sharma A, Bonner-Weir S, Weir GC. Effects of diabetes and hypoxia on gene markers of angiogenesis (HGF, cMET, uPA and uPAR, TGF-alpha, TGF-beta, bFGF and Vimentin) in cultured and transplanted rat islets. Diabetologia. 2000 Jun; 43(6):763-72.
    View in: PubMed
  127. Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes. 2000 May; 49(5):741-8.
    View in: PubMed
  128. Sachs DH, Bonner-Weir S. New islets from old. Nat Med. 2000 Mar; 6(3):250-1.
    View in: PubMed
  129. Trivedi N, Steil GM, Colton CK, Bonner-Weir S, Weir GC. Improved vascularization of planar membrane diffusion devices following continuous infusion of vascular endothelial growth factor. Cell Transplant. 2000 Jan-Feb; 9(1):115-24.
    View in: PubMed
  130. Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes. 1999 Dec; 48(12):2270-6.
    View in: PubMed
  131. Yoon KH, Quickel RR, Tatarkiewicz K, Ulrich TR, Hollister-Lock J, Trivedi N, Bonner-Weir S, Weir GC. Differentiation and expansion of beta cell mass in porcine neonatal pancreatic cell clusters transplanted into nude mice. Cell Transplant. 1999 Nov-Dec; 8(6):673-89.
    View in: PubMed
  132. Feng S, Quickel RR, Hollister-Lock J, McLeod M, Bonner-Weir S, Mulligan RC, Weir GC. Prolonged xenograft survival of islets infected with small doses of adenovirus expressing CTLA4Ig. Transplantation. 1999 Jun 27; 67(12):1607-13.
    View in: PubMed
  133. Wu H, Avgoustiniatos ES, Swette L, Bonner-Weir S, Weir GC, Colton CK. In situ electrochemical oxygen generation with an immunoisolation device. Ann N Y Acad Sci. 1999 Jun 18; 875:105-25.
    View in: PubMed
  134. Jonas JC, Sharma A, Hasenkamp W, Ilkova H, Patanè G, Laybutt R, Bonner-Weir S, Weir GC. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem. 1999 May 14; 274(20):14112-21.
    View in: PubMed
  135. Finegood DT, Weir GC, Bonner-Weir S. Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats. Am J Physiol. 1999 May; 276(5 Pt 1):E822-7.
    View in: PubMed
  136. Tatarkiewicz K, Hollister-Lock J, Quickel RR, Colton CK, Bonner-Weir S, Weir GC. Reversal of hyperglycemia in mice after subcutaneous transplantation of macroencapsulated islets. Transplantation. 1999 Mar 15; 67(5):665-71.
    View in: PubMed
  137. Westphal CH, Muller L, Zhou A, Zhu X, Bonner-Weir S, Schambelan M, Steiner DF, Lindberg I, Leder P. The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease. Cell. 1999 Mar 5; 96(5):689-700.
    View in: PubMed
  138. Charron MJ, Bonner-Weir S. Implicating PARP and NAD+ depletion in type I diabetes. Nat Med. 1999 Mar; 5(3):269-70.
    View in: PubMed
  139. Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, Miller CP, Weir GC, Habener JF, Bonner-Weir S. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes. 1999 Mar; 48(3):507-13.
    View in: PubMed
  140. Kopin AS, Mathes WF, McBride EW, Nguyen M, Al-Haider W, Schmitz F, Bonner-Weir S, Kanarek R, Beinborn M. The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J Clin Invest. 1999 Feb; 103(3):383-91.
    View in: PubMed
  141. Suzuki K, Colton CK, Bonner-Weir S, Hollister J, Weir GC. Estimating number and volume of islets transplanted within a planar immunobarrier diffusion chamber. Methods Mol Med. 1999; 18:497-505.
    View in: PubMed
  142. Vasir B, Aiello LP, Yoon KH, Quickel RR, Bonner-Weir S, Weir GC. Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells. Diabetes. 1998 Dec; 47(12):1894-903.
    View in: PubMed
  143. Weir GC, Bonner-Weir S. Islet transplantation as a treatment for diabetes. J Am Optom Assoc. 1998 Nov; 69(11):727-32.
    View in: PubMed
  144. Suzuki K, Bonner-Weir S, Trivedi N, Yoon KH, Hollister-Lock J, Colton CK, Weir GC. Function and survival of macroencapsulated syngeneic islets transplanted into streptozocin-diabetic mice. Transplantation. 1998 Jul 15; 66(1):21-8.
    View in: PubMed
  145. Pontoglio M, Sreenan S, Roe M, Pugh W, Ostrega D, Doyen A, Pick AJ, Baldwin A, Velho G, Froguel P, Levisetti M, Bonner-Weir S, Bell GI, Yaniv M, Polonsky KS. Defective insulin secretion in hepatocyte nuclear factor 1alpha-deficient mice. J Clin Invest. 1998 May 15; 101(10):2215-22.
    View in: PubMed
  146. Dutta S, Bonner-Weir S, Montminy M, Wright C. Regulatory factor linked to late-onset diabetes? Nature. 1998 Apr 9; 392(6676):560.
    View in: PubMed
  147. Yoon KH, Quickel RR, Tatarkiewicz K, Weir GC, Bonner-Weir S. Growth and differentiation of transplanted porcine neonatal pancreatic cell clusters in normal nude mice. Transplant Proc. 1998 Mar; 30(2):601.
    View in: PubMed
  148. Tatarkiewicz K, Hollister-Lock J, Quickel RR, Cotton CK, Bonner-Weir S, Weir GC. Subcutaneous transplantation of rat islets into diabetic nude. Transplant Proc. 1998 Mar; 30(2):479-80.
    View in: PubMed
  149. Pick A, Clark J, Kubstrup C, Levisetti M, Pugh W, Bonner-Weir S, Polonsky KS. Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat. Diabetes. 1998 Mar; 47(3):358-64.
    View in: PubMed
  150. Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF. Disruption of IRS-2 causes type 2 diabetes in mice. Nature. 1998 Feb 26; 391(6670):900-4.
    View in: PubMed
  151. Suzuki K, Bonner-Weir S, Hollister-Lock J, Colton CK, Weir GC. Number and volume of islets transplanted in immunobarrier devices. Cell Transplant. 1998 Jan-Feb; 7(1):47-52.
    View in: PubMed
  152. Corbett J, Serup P, Bonner-Weir S, Nielsen JH. Beta-cell ontogeny: growth and death. Diabetologia. 1997 Oct; 40 Suppl 3:B27-32.
    View in: PubMed
  153. Weir GC, Sharma A, Zangen DH, Bonner-Weir S. Transcription factor abnormalities as a cause of beta cell dysfunction in diabetes: a hypothesis. Acta Diabetol. 1997 Oct; 34(3):177-84.
    View in: PubMed
  154. Weir GC, Bonner-Weir S. Scientific and political impediments to successful islet transplantation. Diabetes. 1997 Aug; 46(8):1247-56.
    View in: PubMed
  155. Trivedi N, Suzuki K, Bonner-Weir S, Hollister-Lock J, Weir GC. Islet number in an immunobarrier device required to treat diabetes in mice. Transplant Proc. 1997 Jun; 29(4):2142-3.
    View in: PubMed
  156. Scaglia L, Cahill CJ, Finegood DT, Bonner-Weir S. Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology. 1997 Apr; 138(4):1736-41.
    View in: PubMed
  157. Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell. 1997 Feb 21; 88(4):561-72.
    View in: PubMed
  158. Zangen DH, Bonner-Weir S, Lee CH, Latimer JB, Miller CP, Habener JF, Weir GC. Reduced insulin, GLUT2, and IDX-1 in beta-cells after partial pancreatectomy. Diabetes. 1997 Feb; 46(2):258-64.
    View in: PubMed
  159. Weir GC, Quickel RR, Yoon KH, Tatarkiewicz K, Ulrich TR, Hollister-Lock J, Bonner-Weir S. Porcine neonatal pancreatic cell clusters (NPCCs): a potential source of tissue for islet transplantation. Ann Transplant. 1997; 2(3):63-8.
    View in: PubMed
  160. Montaña E, Bonner-Weir S, Weir GC. Beta cell replication and mass in islet transplantation. Adv Exp Med Biol. 1997; 426:421-7.
    View in: PubMed
  161. Suzuki K, Bonner-Weir S, Hollister J, Weir GC. A method for estimating number and mass of islets transplanted within a membrane device. Cell Transplant. 1996 Nov-Dec; 5(6):613-25.
    View in: PubMed
  162. Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC. Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes. 1996 Sep; 45(9):1161-7.
    View in: PubMed
  163. Davalli AM, Napoli R, Weitgasser R, Capotorto JV, Hirshman MF, Finegood DT, Bonner-Weir S, Horton ES, Weir GC. Long-term normalization of GLUT-4 protein content in skeletal muscle of diabetic rats following islet transplantation. J Endocrinol. 1996 Aug; 150(2):255-63.
    View in: PubMed
  164. Juang JH, Bonner-Weir S, Ogawa Y, Vacanti JP, Weir GC. Outcome of subcutaneous islet transplantation improved by polymer device. Transplantation. 1996 Jun 15; 61(11):1557-61.
    View in: PubMed
  165. Verchere CB, D'Alessio DA, Palmiter RD, Weir GC, Bonner-Weir S, Baskin DG, Kahn SE. Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3492-6.
    View in: PubMed
  166. Noma Y, Bonner-Weir S, Latimer JB, Davalli AM, Weir GC. Translocation of glucokinase in pancreatic beta-cells during acute and chronic hyperglycemia. Endocrinology. 1996 Apr; 137(4):1485-91.
    View in: PubMed
  167. Brunicardi FC, Stagner J, Bonner-Weir S, Wayland H, Kleinman R, Livingston E, Guth P, Menger M, McCuskey R, Intaglietta M, Charles A, Ashley S, Cheung A, Ipp E, Gilman S, Howard T, Passaro E. Microcirculation of the islets of Langerhans. Long Beach Veterans Administration Regional Medical Education Center Symposium. Diabetes. 1996 Apr; 45(4):385-92.
    View in: PubMed
  168. Weitgasser R, Davalli AM, Capotorto JV, Finegood DT, Bonner-Weir S, Weir GC. Islet transplantation in diabetic Lewis rats--a comparison of the transplantation sites kidney and spleen capsule. Acta Med Austriaca. 1996; 23(5):156-9.
    View in: PubMed
  169. Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC. Early changes in syngeneic islet grafts: effect of recipient's metabolic control on graft outcome. Transplant Proc. 1995 Dec; 27(6):3238-9.
    View in: PubMed
  170. Scaglia L, Smith FE, Bonner-Weir S. Apoptosis contributes to the involution of beta cell mass in the post partum rat pancreas. Endocrinology. 1995 Dec; 136(12):5461-8.
    View in: PubMed
  171. Weitgasser R, Davalli AM, Napoli R, Capotorto JV, Finegood DT, Bonner-Weir S, Weir GC. Long-term normalization of GLUT 4 protein content in skeletal muscle of streptozotocin-diabetic Lewis rats after islet transplantation. Transplant Proc. 1995 Dec; 27(6):3184-5.
    View in: PubMed
  172. Juang JH, Bonner-Weir S, Vacanti JP, Weir GC. Outcome of subcutaneous islet transplantation improved by a polymer device. Transplant Proc. 1995 Dec; 27(6):3215-6.
    View in: PubMed
  173. Davalli AM, Ogawa Y, Ricordi C, Scharp DW, Bonner-Weir S, Weir GC. A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice. Transplantation. 1995 Mar 27; 59(6):817-20.
    View in: PubMed
  174. Finegood DT, Scaglia L, Bonner-Weir S. Dynamics of beta-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes. 1995 Mar; 44(3):249-56.
    View in: PubMed
  175. Ogawa Y, Noma Y, Davalli AM, Wu YJ, Thorens B, Bonner-Weir S, Weir GC. Loss of glucose-induced insulin secretion and GLUT2 expression in transplanted beta-cells. Diabetes. 1995 Jan; 44(1):75-9.
    View in: PubMed
  176. Davalli AM, Ogawa Y, Scaglia L, Wu YJ, Hollister J, Bonner-Weir S, Weir GC. Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice. Diabetes. 1995 Jan; 44(1):104-11.
    View in: PubMed
  177. Juang JH, Bonner-Weir S, Wu YJ, Weir GC. Beneficial influence of glycemic control upon the growth and function of transplanted islets. Diabetes. 1994 Nov; 43(11):1334-9.
    View in: PubMed
  178. Smith FE, Bonner-Weir S, Leahy JL, Laufgraben MJ, Ogawa Y, Rosen KM, Villa-Komaroff L. Pancreatic Reg/pancreatic stone protein (PSP) gene expression does not correlate with beta-cell growth and regeneration in rats. Diabetologia. 1994 Oct; 37(10):994-9.
    View in: PubMed
  179. Liang Y, Bonner-Weir S, Wu YJ, Berdanier CD, Berner DK, Efrat S, Matschinsky FM. In situ glucose uptake and glucokinase activity of pancreatic islets in diabetic and obese rodents. J Clin Invest. 1994 Jun; 93(6):2473-81.
    View in: PubMed
  180. Davalli AM, Ogawa Y, Scaglia L, Wu YJ, Hollister J, Bonner-Weir S, Weir GC. Porcine islet grafts in diabetic nude mice: dynamic insulin secretion and regulated B-cell mass lower glucose levels to the normal porcine range. Transplant Proc. 1994 Jun; 26(3):1098-9.
    View in: PubMed
  181. Montaña E, Bonner-Weir S, Weir GC. Transplanted beta-cell replication and mass increase after 95% pancreatectomy. Transplant Proc. 1994 Apr; 26(2):657.
    View in: PubMed
  182. Montaña E, Bonner-Weir S, Weir GC. Transplanted beta cell response to increased metabolic demand. Changes in beta cell replication and mass. J Clin Invest. 1994 Apr; 93(4):1577-82.
    View in: PubMed
  183. Bonner-Weir S, Smith FE. Islet cell growth and the growth factors involved. Trends Endocrinol Metab. 1994 Mar; 5(2):60-4.
    View in: PubMed
  184. Bonner-Weir S. Regulation of pancreatic beta-cell mass in vivo. Recent Prog Horm Res. 1994; 49:91-104.
    View in: PubMed
  185. Horio F, Fukuda M, Katoh H, Petruzzelli M, Yano N, Rittershaus C, Bonner-Weir S, Hattori M. Reactive oxygen intermediates in autoimmune islet cell destruction of the NOD mouse induced by peritoneal exudate cells (rich in macrophages) but not T cells. Diabetologia. 1994 Jan; 37(1):22-31.
    View in: PubMed
  186. Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes. 1993 Dec; 42(12):1715-20.
    View in: PubMed
  187. Wang TC, Bonner-Weir S, Oates PS, Chulak M, Simon B, Merlino GT, Schmidt EV, Brand SJ. Pancreatic gastrin stimulates islet differentiation of transforming growth factor alpha-induced ductular precursor cells. J Clin Invest. 1993 Sep; 92(3):1349-56.
    View in: PubMed
  188. Schuppin GT, Bonner-Weir S, Montana E, Kaiser N, Weir GC. Replication of adult pancreatic-beta cells cultured on bovine corneal endothelial cell extracellular matrix. In Vitro Cell Dev Biol Anim. 1993 Apr; 29A(4):339-44.
    View in: PubMed
  189. Montaña E, Bonner-Weir S, Weir GC. Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice. J Clin Invest. 1993 Mar; 91(3):780-7.
    View in: PubMed
  190. Montaña E, Bonner-Weir S, Weir GC. Beta-cell mass falls progressively when hyperglycemia persists after islet transplantation. Transplant Proc. 1992 Dec; 24(6):2996.
    View in: PubMed
  191. Chen C, Thorens B, Bonner-Weir S, Weir GC, Leahy JL. Recovery of glucose-induced insulin secretion in a rat model of NIDDM is not accompanied by return of the B-cell GLUT2 glucose transporter. Diabetes. 1992 Oct; 41(10):1320-7.
    View in: PubMed
  192. Leahy JL, Bonner-Weir S, Weir GC. Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion. Diabetes Care. 1992 Mar; 15(3):442-55.
    View in: PubMed
  193. Gianani R, Pugliese A, Bonner-Weir S, Shiffrin AJ, Soeldner JS, Erlich H, Awdeh Z, Alper CA, Jackson RA, Eisenbarth GS. Prognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with type I diabetes. Diabetes. 1992 Mar; 41(3):347-53.
    View in: PubMed
  194. Smith FE, Rosen KM, Villa-Komaroff L, Weir GC, Bonner-Weir S. Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6152-6.
    View in: PubMed
  195. McCulloch DK, Koerker DJ, Kahn SE, Bonner-Weir S, Palmer JP. Correlations of in vivo beta-cell function tests with beta-cell mass and pancreatic insulin content in streptozocin-administered baboons. Diabetes. 1991 Jun; 40(6):673-9.
    View in: PubMed
  196. Meyerovitch J, Rothenberg P, Shechter Y, Bonner-Weir S, Kahn CR. Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus. J Clin Invest. 1991 Apr; 87(4):1286-94.
    View in: PubMed
  197. Thorens B, Weir GC, Leahy JL, Lodish HF, Bonner-Weir S. Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6492-6.
    View in: PubMed
  198. Helton WS, Jacobs DO, Bonner-Weir S, Bueno R, Smith RJ, Wilmore DW. Effects of glutamine-enriched parenteral nutrition on the exocrine pancreas. JPEN J Parenter Enteral Nutr. 1990 Jul-Aug; 14(4):344-52.
    View in: PubMed
  199. Weir GC, Bonner-Weir S, Leahy JL. Islet mass and function in diabetes and transplantation. Diabetes. 1990 Apr; 39(4):401-5.
    View in: PubMed
  200. Weir GC, Bonner-Weir S. Islets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes. J Clin Invest. 1990 Apr; 85(4):983-7.
    View in: PubMed
  201. Ziegler AG, Vardi P, Gross DJ, Bonner-Weir S, Villa-Komaroff L, Halban PA, Ikegami H, Soeldner JS, Eisenbarth GS. Production of insulin antibodies by mice rejecting insulin transfected cells. J Autoimmun. 1989 Jun; 2(3):219-27.
    View in: PubMed
  202. Lee HC, Bonner-Weir S, Weir GC, Leahy JL. Compensatory adaption to partial pancreatectomy in the rat. Endocrinology. 1989 Mar; 124(3):1571-5.
    View in: PubMed
  203. Bonner-Weir S, Deery D, Leahy JL, Weir GC. Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes. 1989 Jan; 38(1):49-53.
    View in: PubMed
  204. Stagner JI, Samols E, Bonner-Weir S. beta----alpha----delta pancreatic islet cellular perfusion in dogs. Diabetes. 1988 Dec; 37(12):1715-21.
    View in: PubMed
  205. Halban PA, Powers SL, George KL, Bonner-Weir S. Altered differentiated cell surface properties of transformed (RINm5F) compared with native adult rat pancreatic B cells. Endocrinology. 1988 Jul; 123(1):113-9.
    View in: PubMed
  206. Bonner-Weir S. Morphological evidence for pancreatic polarity of beta-cell within islets of Langerhans. Diabetes. 1988 May; 37(5):616-21.
    View in: PubMed
  207. Leahy JL, Bonner-Weir S, Weir GC. Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy. J Clin Invest. 1988 May; 81(5):1407-14.
    View in: PubMed
  208. Brockenbrough JS, Weir GC, Bonner-Weir S. Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats. Diabetes. 1988 Feb; 37(2):232-6.
    View in: PubMed
  209. Halban PA, Powers SL, George KL, Bonner-Weir S. Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets. Diabetes. 1987 Jul; 36(7):783-90.
    View in: PubMed
  210. Gotoh M, Maki T, Satomi S, Porter J, Bonner-Weir S, O'Hara CJ, Monaco AP. Reproducible high yield of rat islets by stationary in vitro digestion following pancreatic ductal or portal venous collagenase injection. Transplantation. 1987 May; 43(5):725-30.
    View in: PubMed
  211. Colella RM, May JM, Bonner-Weir S, Leahy JL, Weir GC. Glucose utilization in islets of hyperglycemic rat models with impaired glucose-induced insulin secretion. Metabolism. 1987 Apr; 36(4):335-7.
    View in: PubMed
  212. Samols E, Bonner-Weir S, Weir GC. Intra-islet insulin-glucagon-somatostatin relationships. Clin Endocrinol Metab. 1986 Feb; 15(1):33-58.
    View in: PubMed
  213. Weir GC, Leahy JL, Bonner-Weir S. Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes. Diabetes Metab Rev. 1986; 2(1-2):125-61.
    View in: PubMed
  214. Colella RM, Bonner-Weir S, Braunstein LP, Schwalke M, Weir GC. Pancreatic islets of variable size--insulin secretion and glucose utilization. Life Sci. 1985 Sep 16; 37(11):1059-65.
    View in: PubMed
  215. Leahy JL, Bonner-Weir S, Weir GC. Abnormal insulin secretion in a streptozocin model of diabetes. Effects of insulin treatment. Diabetes. 1985 Jul; 34(7):660-6.
    View in: PubMed
  216. Giddings SJ, Orland MJ, Weir GC, Bonner-Weir S, Permutt MA. Impaired insulin biosynthetic capacity in a rat model for non-insulin-dependent diabetes. Studies with dexamethasone. Diabetes. 1985 Mar; 34(3):235-40.
    View in: PubMed
  217. Weir GC, Bonner-Weir S. Pancreatic somatostatin. Adv Exp Med Biol. 1985; 188:403-23.
    View in: PubMed
  218. Leahy JL, Bonner-Weir S, Weir GC. Abnormal glucose regulation of insulin secretion in models of reduced B-cell mass. Diabetes. 1984 Jul; 33(7):667-73.
    View in: PubMed
  219. Permutt MA, Kakita K, Malinas P, Karl I, Bonner-Weir S, Weir G, Giddings SJ. An in vivo analysis of pancreatic protein and insulin biosynthesis in a rat model for non-insulin-dependent diabetes. J Clin Invest. 1984 May; 73(5):1344-50.
    View in: PubMed
  220. Trent DF, Fletcher DJ, May JM, Bonner-Weir S, Weir GC. Abnormal islet and adipocyte function in young B-cell-deficient rats with near-normoglycemia. Diabetes. 1984 Feb; 33(2):170-5.
    View in: PubMed
  221. Bonner-Weir S, Trent DF, Weir GC. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest. 1983 Jun; 71(6):1544-53.
    View in: PubMed
  222. Halban PA, Bonner-Weir S, Weir GC. Elevated proinsulin biosynthesis in vitro from a rat model of non-insulin-dependent diabetes mellitus. Diabetes. 1983 Mar; 32(3):277-83.
    View in: PubMed
  223. Bonner-Weir S, Orci L. New perspectives on the microvasculature of the islets of Langerhans in the rat. Diabetes. 1982 Oct; 31(10):883-9.
    View in: PubMed
  224. Roth J, Bonner-Weir S, Norman AW, Orci L. Immunocytochemistry of vitamin D-dependent calcium binding protein in chick pancreas: exclusive localization. Endocrinology. 1982 Jun; 110(6):2216-8.
    View in: PubMed
  225. Bonner-Weir S, Trent DF, Zmachinski CJ, Clore ET, Weir GC. Limited B cell regeneration in a B cell deficient rat model: studies with dexamethasone. Metabolism. 1981 Sep; 30(9):914-8.
    View in: PubMed
  226. Weir GC, Clore ET, Zmachinski CJ, Bonner-Weir S. Islet secretion in a new experimental model for non-insulin-dependent diabetes. Diabetes. 1981 Jul; 30(7):590-5.
    View in: PubMed
  227. Bonner-Weir S, Trent DF, Honey RN, Weir GC. Responses of neonatal rat islets to streptozotocin: limited B-cell regeneration and hyperglycemia. Diabetes. 1981 Jan; 30(1):64-9.
    View in: PubMed
  228. Bonner-Weir S, Like AA. A dual population of islets of Langerhans in bovine pancreas. Cell Tissue Res. 1980; 206(1):157-70.
    View in: PubMed
  229. Weir GC, Bonner-Weir S, Edwards DC. Nerve growth factor and pancreatic APUD cells. Endocr Res Commun. 1980; 7(1):71-5.
    View in: PubMed
  230. Bonner-Weir S, Weir GC. The organization of the endocrine pancreas: a hypothetical unifying view of the phylogenetic differences. Gen Comp Endocrinol. 1979 May; 38(1):28-37.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Bonner-Weir's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
See all (654) concept(s)
_
Co-Authors
See all (76) people
_
Similar People
See all (60) people
_
Same Department
Search Department
Physical Neighbors
_