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Christophe O. Benoist, Ph.D., M.D.

TitleMorton Grove-Rasmussen Professor of Immunohematology
InstitutionHarvard Medical School
DepartmentMicrobiology and Immunobiology
AddressHarvard Medical School
Pathology, NRB 1052G
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-7743
Fax617/432-7744

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF. Regulatory T cells: recommendations to simplify the nomenclature. Nat Immunol. 2013 Apr; 14(4):307-8.
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  2. Best JA, Blair DA, Knell J, Yang E, Mayya V, Doedens A, Dustin ML, Goldrath AW, Monach P, Shinton SA, Hardy RR, Jianu R, Koller D, Collins J, Gazit R, Garrison BS, Rossi DJ, Narayan K, Sylvia K, Kang J, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S, Best JA, Knell J, Goldrath AW, Jojic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kreslavsky T, Bezman NA, Sun JC, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Kim F, Rao TN, Wagers A, Heng T, Painter M, Ericson J, Davis S, Ergun A, Mingueneau M, Mathis D, Benoist C. Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nat Immunol. 2013 Apr; 14(4):404-12.
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  3. Shay T, Jojic V, Zuk O, Rothamel K, Puyraimond-Zemmour D, Feng T, Wakamatsu E, Benoist C, Koller D, Regev A. Conservation and divergence in the transcriptional programs of the human and mouse immune systems. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2946-51.
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  4. Shu CJ, Benoist C, Mathis D. The immune system's involvement in obesity-driven type 2 diabetes. Semin Immunol. 2012 Dec; 24(6):436-42.
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  5. Yang S, Bansal K, Lopes J, Benoist C, Mathis D. Aire's plant homeodomain(PHD)-2 is critical for induction of immunological tolerance. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):1833-8.
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  6. Wakamatsu E, Mathis D, Benoist C. Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells. Proc Natl Acad Sci U S A. 2013 Jan 15; 110(3):1023-8.
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  7. Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB, Monach P, Shinton SA, Hardy RR, Jianu R, Koller D, Collins J, Gazit R, Garrison BS, Rossi DJ, Narayan K, Sylvia K, Kang J, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S, Best AJ, Knell J, Goldrath A, Jojic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kreslavsky T, Bezman NA, Sun JC, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Kim F, Rao TN, Wagers A, Heng T, Painter M, Ericson J, Davis S, Ergun A, Mingueneau M, Mathis D, Benoist C. Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nat Immunol. 2013 Jan; 14(1):90-9.
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  8. Donner Y, Feng T, Benoist C, Koller D. Imputing gene expression from selectively reduced probe sets. Nat Methods. 2012 Nov; 9(11):1120-5.
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  9. Fu W, Ergun A, Lu T, Hill JA, Haxhinasto S, Fassett MS, Gazit R, Adoro S, Glimcher L, Chan S, Kastner P, Rossi D, Collins JJ, Mathis D, Benoist C. A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells. Nat Immunol. 2012 Oct; 13(10):972-80.
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  10. Benoist C, Lanier L, Merad M, Mathis D. Consortium biology in immunology: the perspective from the Immunological Genome Project. Nat Rev Immunol. 2012 Oct; 12(10):734-40.
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  11. Lim AS, Chang AM, Shulman JM, Raj T, Chibnik LB, Cain SW, Rothamel K, Benoist C, Myers AJ, Czeisler CA, Buchman AS, Bennett DA, Duffy JF, Saper CB, De Jager PL. A common polymorphism near PER1 and the timing of human behavioral rhythms. Ann Neurol. 2012 Sep; 72(3):324-34.
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  12. Benoist C, Mathis D. Treg cells, life history, and diversity. Cold Spring Harb Perspect Biol. 2012 Sep; 4(9):a007021.
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  13. Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson SE, Benoist C, Mathis D. PPAR-? is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature. 2012 Jun 28; 486(7404):549-53.
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  14. Chung H, Pamp SJ, Hill JA, Surana NK, Edelman SM, Troy EB, Reading NC, Villablanca EJ, Wang S, Mora JR, Umesaki Y, Mathis D, Benoist C, Relman DA, Kasper DL. Gut immune maturation depends on colonization with a host-specific microbiota. Cell. 2012 Jun 22; 149(7):1578-93.
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  15. Darce J, Rudra D, Li L, Nishio J, Cipolletta D, Rudensky AY, Mathis D, Benoist C. An N-terminal mutation of the foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity. 2012 May 25; 36(5):731-41.
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  16. Fu W, Wojtkiewicz G, Weissleder R, Benoist C, Mathis D. Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nat Immunol. 2012 Apr; 13(4):361-8.
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  17. Fassett MS, Jiang W, D'Alise AM, Mathis D, Benoist C. Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion. Proc Natl Acad Sci U S A. 2012 Mar 6; 109(10):3891-6.
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  18. Mingueneau M, Jiang W, Feuerer M, Mathis D, Benoist C. Thymic negative selection is functional in NOD mice. J Exp Med. 2012 Mar 12; 209(3):623-37.
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  19. Rao SM, Auger JL, Gaillard P, Weissleder R, Wada E, Torres R, Kojima M, Benoist C, Mathis D, Binstadt BA. The neuropeptide neuromedin U promotes autoantibody-mediated arthritis. Arthritis Res Ther. 2012; 14(1):R29.
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  20. Mathis D, Benoist C. The influence of the microbiota on type-1 diabetes: on the threshold of a leap forward in our understanding. Immunol Rev. 2012 Jan; 245(1):239-49.
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  21. Giraud M, Yoshida H, Abramson J, Rahl PB, Young RA, Mathis D, Benoist C. Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):535-40.
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  22. Feyerabend TB, Weiser A, Tietz A, Stassen M, Harris N, Kopf M, Radermacher P, Möller P, Benoist C, Mathis D, Fehling HJ, Rodewald HR. Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity. Immunity. 2011 Nov 23; 35(5):832-44.
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  23. Allison JP, Benoist C, Chervonsky AV. Nobels: Toll pioneers deserve recognition. Nature. 2011 Nov 10; 479(7372):178.
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  24. Mathis D, Benoist C. Microbiota and autoimmune disease: the hosted self. Cell Host Microbe. 2011 Oct 20; 10(4):297-301.
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  25. Johnsen AK, Valdar W, Golden L, Ortiz-Lopez A, Hitzemann R, Flint J, Mathis D, Benoist C. Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice. Arthritis Rheum. 2011 Sep; 63(9):2630-40.
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  26. Reiner T, Thurber G, Gaglia J, Vinegoni C, Liew CW, Upadhyay R, Kohler RH, Li L, Kulkarni RN, Benoist C, Mathis D, Weissleder R. Accurate measurement of pancreatic islet beta-cell mass using a second-generation fluorescent exendin-4 analog. Proc Natl Acad Sci U S A. 2011 Aug 2; 108(31):12815-20.
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  27. Cipolletta D, Kolodin D, Benoist C, Mathis D. Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism. Semin Immunol. 2011 Dec; 23(6):431-7.
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  28. Kriegel MA, Sefik E, Hill JA, Wu HJ, Benoist C, Mathis D. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11548-53.
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  29. Benoist C, Hacohen N. Immunology. Flow cytometry, amped up. Science. 2011 May 6; 332(6030):677-8.
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  30. D'Alise AM, Ergun A, Hill JA, Mathis D, Benoist C. A cluster of coregulated genes determines TGF-beta-induced regulatory T-cell (Treg) dysfunction in NOD mice. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8737-42.
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  31. Bandukwala HS, Wu Y, Feuerer M, Chen Y, Barboza B, Ghosh S, Stroud JC, Benoist C, Mathis D, Rao A, Chen L. Structure of a domain-swapped FOXP3 dimer on DNA and its function in regulatory T cells. Immunity. 2011 Apr 22; 34(4):479-91.
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  32. Painter MW, Davis S, Hardy RR, Mathis D, Benoist C. Transcriptomes of the B and T lineages compared by multiplatform microarray profiling. J Immunol. 2011 Mar 1; 186(5):3047-57.
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  33. Huang GJ, Smith AL, Gray DH, Cosgrove C, Singer BH, Edwards A, Sims S, Sim S, Parent JM, Johnsen A, Mott R, Mathis D, Klenerman P, Benoist C, Flint J. A genetic and functional relationship between T cells and cellular proliferation in the adult hippocampus. PLoS Biol. 2010; 8(12):e1000561.
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  34. Gaglia JL, Guimaraes AR, Harisinghani M, Turvey SE, Jackson R, Benoist C, Mathis D, Weissleder R. Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients. J Clin Invest. 2011 Jan; 121(1):442-5.
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  35. Rubtsov YP, Niec RE, Josefowicz S, Li L, Darce J, Mathis D, Benoist C, Rudensky AY. Stability of the regulatory T cell lineage in vivo. Science. 2010 Sep 24; 329(5999):1667-71.
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  36. Yalcin B, Nicod J, Bhomra A, Davidson S, Cleak J, Farinelli L, Østerås M, Whitley A, Yuan W, Gan X, Goodson M, Klenerman P, Satpathy A, Mathis D, Benoist C, Adams DJ, Mott R, Flint J. Commercially available outbred mice for genome-wide association studies. PLoS Genet. 2010 Sep; 6(9).
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  37. Nishio J, Feuerer M, Wong J, Mathis D, Benoist C. Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor-specified peripheral niche constraints. J Exp Med. 2010 Aug 30; 207(9):1879-89.
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  38. Koh AS, Kingston RE, Benoist C, Mathis D. Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13016-21.
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  39. Jacobs JP, Ortiz-Lopez A, Campbell JJ, Gerard CJ, Mathis D, Benoist C. Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model. Arthritis Rheum. 2010 Jul; 62(7):1921-32.
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  40. Wu HJ, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y, Littman DR, Benoist C, Mathis D. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity. 2010 Jun 25; 32(6):815-27.
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  41. Iwai LK, Benoist C, Mathis D, White FM. Quantitative phosphoproteomic analysis of T cell receptor signaling in diabetes prone and resistant mice. J Proteome Res. 2010 Jun 4; 9(6):3135-45.
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  42. Suwanai H, Wilcox MA, Mathis D, Benoist C. A defective Il15 allele underlies the deficiency in natural killer cell activity in nonobese diabetic mice. Proc Natl Acad Sci U S A. 2010 May 18; 107(20):9305-10.
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  43. Feuerer M, Hill JA, Kretschmer K, von Boehmer H, Mathis D, Benoist C. Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13):5919-24.
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  44. Monach PA, Nigrovic PA, Chen M, Hock H, Lee DM, Benoist C, Mathis D. Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1. Arthritis Rheum. 2010 Mar; 62(3):753-64.
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  45. Huang H, Benoist C, Mathis D. Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis. Proc Natl Acad Sci U S A. 2010 Mar 9; 107(10):4658-63.
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  46. Abramson J, Giraud M, Benoist C, Mathis D. Aire's partners in the molecular control of immunological tolerance. Cell. 2010 Jan 8; 140(1):123-35.
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  47. Mathis D, Benoist C. Levees of immunological tolerance. Nat Immunol. 2010 Jan; 11(1):3-6.
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  48. Jacobs JP, Wu HJ, Benoist C, Mathis D. IL-17-producing T cells can augment autoantibody-induced arthritis. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21789-94.
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  49. Feuerer M, Shen Y, Littman DR, Benoist C, Mathis D. How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. Immunity. 2009 Oct 16; 31(4):654-64.
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  50. Binstadt BA, Hebert JL, Ortiz-Lopez A, Bronson R, Benoist C, Mathis D. The same systemic autoimmune disease provokes arthritis and endocarditis via distinct mechanisms. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16758-63.
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  51. Monach PA, Hueber W, Kessler B, Tomooka BH, BenBarak M, Simmons BP, Wright J, Thornhill TS, Monestier M, Ploegh H, Robinson WH, Mathis D, Benoist C. A broad screen for targets of immune complexes decorating arthritic joints highlights deposition of nucleosomes in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15867-72.
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  52. Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U. Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis Rheum. 2009 Aug; 60(8):2314-24.
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  53. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009 Aug; 15(8):930-9.
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  54. Feuerer M, Hill JA, Mathis D, Benoist C. Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol. 2009 Jul; 10(7):689-95.
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  55. Guerau-de-Arellano M, Martinic M, Benoist C, Mathis D. Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity. J Exp Med. 2009 Jun 8; 206(6):1245-52.
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  56. Mathis D, Benoist C. Aire. Annu Rev Immunol. 2009; 27:287-312.
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  57. D'Alise AM, Auyeung V, Feuerer M, Nishio J, Fontenot J, Benoist C, Mathis D. The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19857-62.
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  58. Hill JA, Hall JA, Sun CM, Cai Q, Ghyselinck N, Chambon P, Belkaid Y, Mathis D, Benoist C. Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. Immunity. 2008 Nov 14; 29(5):758-70.
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  59. Nigrovic PA, Gray DH, Jones T, Hallgren J, Kuo FC, Chaletzky B, Gurish M, Mathis D, Benoist C, Lee DM. Genetic inversion in mast cell-deficient (Wsh) mice interrupts corin and manifests as hematopoietic and cardiac aberrancy. Am J Pathol. 2008 Dec; 173(6):1693-701.
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  60. Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, Mathis D. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15878-83.
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  61. Venanzi ES, Melamed R, Mathis D, Benoist C. The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcription. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15860-5.
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  62. Villaseñor J, Besse W, Benoist C, Mathis D. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15854-9.
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  63. Guerau-de-Arellano M, Mathis D, Benoist C. Transcriptional impact of Aire varies with cell type. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14011-6.
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  64. Gavanescu I, Benoist C, Mathis D. B cells are required for Aire-deficient mice to develop multi-organ autoinflammation: A therapeutic approach for APECED patients. Proc Natl Acad Sci U S A. 2008 Sep 2; 105(35):13009-14.
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  65. Johnsen AK, Plenge RM, Butty V, Campbell C, Dieguez-Gonzalez R, Gomez-Reino JJ, Shadick N, Weinblatt M, Gonzalez A, Gregersen PK, Benoist C, Mathis D. A broad analysis of IL1 polymorphism and rheumatoid arthritis. Arthritis Rheum. 2008 Jul; 58(7):1947-57.
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  66. Butty V, Campbell C, Mathis D, Benoist C. Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1). Diabetes. 2008 Sep; 57(9):2348-59.
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  67. Haxhinasto S, Mathis D, Benoist C. The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells. J Exp Med. 2008 Mar 17; 205(3):565-74.
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  68. Feuerer M, Jiang W, Holler PD, Satpathy A, Campbell C, Bogue M, Mathis D, Benoist C. Enhanced thymic selection of FoxP3+ regulatory T cells in the NOD mouse model of autoimmune diabetes. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18181-6.
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  69. Gray DH, Gavanescu I, Benoist C, Mathis D. Danger-free autoimmune disease in Aire-deficient mice. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18193-8.
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  70. Hill JA, Feuerer M, Tash K, Haxhinasto S, Perez J, Melamed R, Mathis D, Benoist C. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity. 2007 Nov; 27(5):786-800.
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  71. Mathis D, Benoist C. Yes, it does. Nat Rev Immunol. 2007 Oct 12; 7(10):1.
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  72. Gray D, Abramson J, Benoist C, Mathis D. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med. 2007 Oct 29; 204(11):2521-8.
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  73. Obst R, van Santen HM, Melamed R, Kamphorst AO, Benoist C, Mathis D. Sustained antigen presentation can promote an immunogenic T cell response, like dendritic cell activation. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15460-5.
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  74. Wong J, Mathis D, Benoist C. TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J Exp Med. 2007 Sep 3; 204(9):2039-45.
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  75. Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D. Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk. J Exp Med. 2007 Aug 6; 204(8):1911-22.
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  76. Mathis D, Benoist C. A decade of AIRE. Nat Rev Immunol. 2007 Aug; 7(8):645-50.
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  77. Wong J, Obst R, Correia-Neves M, Losyev G, Mathis D, Benoist C. Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol. 2007 Jun 1; 178(11):7032-41.
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  78. Holler PD, Yamagata T, Jiang W, Feuerer M, Benoist C, Mathis D. The same genomic region conditions clonal deletion and clonal deviation to the CD8alphaalpha and regulatory T cell lineages in NOD versus C57BL/6 mice. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7187-92.
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  79. Liston A, Farr AG, Chen Z, Benoist C, Mathis D, Manley NR, Rudensky AY. Lack of Foxp3 function and expression in the thymic epithelium. J Exp Med. 2007 Mar 19; 204(3):475-80.
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  80. Gavanescu I, Kessler B, Ploegh H, Benoist C, Mathis D. Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4583-7.
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  81. Haxhinasto S, Benoist C, Mathis D. Regulatory T-cell differentiation: Committed to control: a precocious choice? Immunol Cell Biol. 2007 Apr-May; 85(3):175-6.
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  82. Hill JA, Benoist C, Mathis D. Treg cells: guardians for life. Nat Immunol. 2007 Feb; 8(2):124-5.
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  83. Nguyen LT, Jacobs J, Mathis D, Benoist C. Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis. Arthritis Rheum. 2007 Feb; 56(2):509-20.
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  84. Rodacki M, Svoren B, Butty V, Besse W, Laffel L, Benoist C, Mathis D. Altered natural killer cells in type 1 diabetic patients. Diabetes. 2007 Jan; 56(1):177-85.
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  85. Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D. Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes. Proc Natl Acad Sci U S A. 2007 Jan 9; 104(2):570-5.
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  86. Chen Z, Stockton J, Mathis D, Benoist C. Modeling CTLA4-linked autoimmunity with RNA interference in mice. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16400-5.
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  87. Wu Y, Borde M, Heissmeyer V, Feuerer M, Lapan AD, Stroud JC, Bates DL, Guo L, Han A, Ziegler SF, Mathis D, Benoist C, Chen L, Rao A. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell. 2006 Jul 28; 126(2):375-87.
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  88. Hyatt G, Melamed R, Park R, Seguritan R, Laplace C, Poirot L, Zucchelli S, Obst R, Matos M, Venanzi E, Goldrath A, Nguyen L, Luckey J, Yamagata T, Herman A, Jacobs J, Mathis D, Benoist C. Gene expression microarrays: glimpses of the immunological genome. Nat Immunol. 2006 Jul; 7(7):686-91.
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  89. Yamagata T, Benoist C, Mathis D. A shared gene-expression signature in innate-like lymphocytes. Immunol Rev. 2006 Apr; 210:52-66.
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  90. Benoist C, Germain RN, Mathis D. A plaidoyer for 'systems immunology'. Immunol Rev. 2006 Apr; 210:229-34.
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  91. Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D. Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science. 2006 Mar 24; 311(5768):1775-8.
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  92. Huang H, Kearney JF, Grusby MJ, Benoist C, Mathis D. Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen. Proc Natl Acad Sci U S A. 2006 Mar 7; 103(10):3734-9.
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  93. Luckey CJ, Bhattacharya D, Goldrath AW, Weissman IL, Benoist C, Mathis D. Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3304-9.
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  94. Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, Weissleder R, Mathis D, Benoist C. Particularities of the vasculature can promote the organ specificity of autoimmune attack. Nat Immunol. 2006 Mar; 7(3):284-92.
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  95. Turley SJ, Lee JW, Dutton-Swain N, Mathis D, Benoist C. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci U S A. 2005 Dec 6; 102(49):17729-33.
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  96. Chen Z, Herman AE, Matos M, Mathis D, Benoist C. Where CD4+CD25+ T reg cells impinge on autoimmune diabetes. J Exp Med. 2005 Nov 21; 202(10):1387-97.
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  97. Chen Z, Benoist C, Mathis D. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14735-40.
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  98. Jiang W, Anderson MS, Bronson R, Mathis D, Benoist C. Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med. 2005 Sep 19; 202(6):805-15.
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  99. Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R, Mathis D. Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes. J Clin Invest. 2005 Sep; 115(9):2454-61.
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  100. Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, Mathis D. The cellular mechanism of Aire control of T cell tolerance. Immunity. 2005 Aug; 23(2):227-39.
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  101. Ohmura K, Nguyen LT, Locksley RM, Mathis D, Benoist C. Interleukin-4 can be a key positive regulator of inflammatory arthritis. Arthritis Rheum. 2005 Jun; 52(6):1866-75.
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  102. Obst R, van Santen HM, Mathis D, Benoist C. Antigen persistence is required throughout the expansion phase of a CD4(+) T cell response. J Exp Med. 2005 May 16; 201(10):1555-65.
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  103. Villaseñor J, Benoist C, Mathis D. AIRE and APECED: molecular insights into an autoimmune disease. Immunol Rev. 2005 Apr; 204:156-64.
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  104. Zucchelli S, Holler P, Yamagata T, Roy M, Benoist C, Mathis D. Defective central tolerance induction in NOD mice: genomics and genetics. Immunity. 2005 Mar; 22(3):385-96.
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  105. Goldrath AW, Luckey CJ, Park R, Benoist C, Mathis D. The molecular program induced in T cells undergoing homeostatic proliferation. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16885-90.
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  106. van Santen HM, Benoist C, Mathis D. Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells. J Exp Med. 2004 Nov 15; 200(10):1221-30.
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  107. Matos M, Park R, Mathis D, Benoist C. Progression to islet destruction in a cyclophosphamide-induced transgenic model: a microarray overview. Diabetes. 2004 Sep; 53(9):2310-21.
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  108. Denis MC, Mahmood U, Benoist C, Mathis D, Weissleder R. Imaging inflammation of the pancreatic islets in type 1 diabetes. Proc Natl Acad Sci U S A. 2004 Aug 24; 101(34):12634-9.
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  109. Herman AE, Freeman GJ, Mathis D, Benoist C. CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med. 2004 Jun 7; 199(11):1479-89.
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  110. Poirot L, Benoist C, Mathis D. Natural killer cells distinguish innocuous and destructive forms of pancreatic islet autoimmunity. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8102-7.
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  111. Yamagata T, Mathis D, Benoist C. Self-reactivity in thymic double-positive cells commits cells to a CD8 alpha alpha lineage with characteristics of innate immune cells. Nat Immunol. 2004 Jun; 5(6):597-605.
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  112. Mathis D, Benoist C. Back to central tolerance. Immunity. 2004 May; 20(5):509-16.
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  113. Monach PA, Benoist C, Mathis D. The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease. Adv Immunol. 2004; 82:217-48.
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  114. Turley S, Poirot L, Hattori M, Benoist C, Mathis D. Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med. 2003 Nov 17; 198(10):1527-37.
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  115. Benoist C, Mathis D. Mast cells in autoimmune disease. Nature. 2002 Dec 19-26; 420(6917):875-8.
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  116. Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, von Boehmer H, Bronson R, Dierich A, Benoist C, Mathis D. Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002 Nov 15; 298(5597):1395-401.
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  117. Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB. Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science. 2002 Sep 6; 297(5587):1689-92.
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  118. Ji H, Pettit A, Ohmura K, Ortiz-Lopez A, Duchatelle V, Degott C, Gravallese E, Mathis D, Benoist C. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med. 2002 Jul 1; 196(1):77-85.
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  119. Goldrath AW, Sivakumar PV, Glaccum M, Kennedy MK, Bevan MJ, Benoist C, Mathis D, Butz EA. Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells. J Exp Med. 2002 Jun 17; 195(12):1515-22.
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  120. Maccioni M, Zeder-Lutz G, Huang H, Ebel C, Gerber P, Hergueux J, Marchal P, Duchatelle V, Degott C, van Regenmortel M, Benoist C, Mathis D. Arthritogenic monoclonal antibodies from K/BxN mice. J Exp Med. 2002 Apr 15; 195(8):1071-7.
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  121. Matsumoto I, Maccioni M, Lee DM, Maurice M, Simmons B, Brenner M, Mathis D, Benoist C. How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol. 2002 Apr; 3(4):360-5.
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  122. Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D. Arthritis critically dependent on innate immune system players. Immunity. 2002 Feb; 16(2):157-68.
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  123. Mathis D, Vence L, Benoist C. beta-Cell death during progression to diabetes. Nature. 2001 Dec 13; 414(6865):792-8.
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  124. Gonzalez A, Andre-Schmutz I, Carnaud C, Mathis D, Benoist C. Damage control, rather than unresponsiveness, effected by protective DX5+ T cells in autoimmune diabetes. Nat Immunol. 2001 Dec; 2(12):1117-25.
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  125. Ji H, Gauguier D, Ohmura K, Gonzalez A, Duchatelle V, Danoy P, Garchon HJ, Degott C, Lathrop M, Benoist C, Mathis D. Genetic influences on the end-stage effector phase of arthritis. J Exp Med. 2001 Aug 6; 194(3):321-30.
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  126. Labrecque N, Whitfield LS, Obst R, Waltzinger C, Benoist C, Mathis D. How much TCR does a T cell need? Immunity. 2001 Jul; 15(1):71-82.
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  127. Vivien L, Benoist C, Mathis D. T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo. Int Immunol. 2001 Jun; 13(6):763-8.
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  128. Correia-Neves M, Waltzinger C, Mathis D, Benoist C. The shaping of the T cell repertoire. Immunity. 2001 Jan; 14(1):21-32.
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  129. van Santen H, Benoist C, Mathis D. A cassette vector for high-level reporter expression driven by a hybrid invariant chain promoter in transgenic mice. J Immunol Methods. 2000 Nov 1; 245(1-2):133-7.
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  130. Luhder F, Chambers C, Allison JP, Benoist C, Mathis D. Pinpointing when T cell costimulatory receptor CTLA-4 must be engaged to dampen diabetogenic T cells. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12204-9.
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  131. Leenders H, Whiffield S, Benoist C, Mathis D. Role of the forkhead transcription family member, FKHR, in thymocyte differentiation. Eur J Immunol. 2000 Oct; 30(10):2980-90.
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  132. El Ghouzzi V, Legeai-Mallet L, Aresta S, Benoist C, Munnich A, de Gunzburg J, Bonaventure J. Saethre-Chotzen mutations cause TWIST protein degradation or impaired nuclear location. Hum Mol Genet. 2000 Mar 22; 9(5):813-9.
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  133. Benoist C, Mathis D. A revival of the B cell paradigm for rheumatoid arthritis pathogenesis? Arthritis Res. 2000; 2(2):90-4.
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  134. Witherden D, van Oers N, Waltzinger C, Weiss A, Benoist C, Mathis D. Tetracycline-controllable selection of CD4(+) T cells: half-life and survival signals in the absence of major histocompatibility complex class II molecules. J Exp Med. 2000 Jan 17; 191(2):355-64.
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  135. Rooke R, Benoist C, Mathis D. Intrathymic delivery of MHC genes using recombinant adenoviruses. Methods Mol Biol. 2000; 134:69-79.
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  136. Mangialaio S, Ji H, Korganow AS, Kouskoff V, Benoist C, Mathis D. The arthritogenic T cell receptor and its ligand in a model of spontaneous arthritis. Arthritis Rheum. 1999 Dec; 42(12):2517-23.
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  137. Matsumoto I, Staub A, Benoist C, Mathis D. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science. 1999 Nov 26; 286(5445):1732-5.
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  138. Correia-Neves M, Waltzinger C, Wurtz JM, Benoist C, Mathis D. Amino acids specifying MHC class preference in TCR V alpha 2 regions. J Immunol. 1999 Nov 15; 163(10):5471-7.
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  139. Labrecque N, Madsen L, Fugger L, Benoist C, Mathis D. Toxic MHC class II beta chains. Immunity. 1999 Nov; 11(5):515-6.
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  140. Rooke R, Waltzinger C, Benoist C, Mathis D. Positive selection of thymocytes induced by gene transfer: MHC class II-mediated selection of CD8 lineage cells. Int Immunol. 1999 Oct; 11(10):1595-600.
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  141. Chan S, Waltzinger C, Tarakhovsky A, Benoist C, Mathis D. An influence of CD5 on the selection of CD4-lineage T cells. Eur J Immunol. 1999 Sep; 29(9):2916-22.
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  142. Benoist C, Mathis D. Spotting a killer's target in autoimmune diabetes. Nat Med. 1999 Sep; 5(9):992-3.
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  143. Madsen L, Labrecque N, Engberg J, Dierich A, Svejgaard A, Benoist C, Mathis D, Fugger L. Mice lacking all conventional MHC class II genes. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10338-43.
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  144. Ji H, Korganow AS, Mangialaio S, Höglund P, André I, Lühder F, Gonzalez A, Poirot L, Benoist C, Mathis D. Different modes of pathogenesis in T-cell-dependent autoimmunity: clues from two TCR transgenic systems. Immunol Rev. 1999 Jun; 169:139-46.
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  145. Korganow AS, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, Degott C, Kikutani H, Rajewsky K, Pasquali JL, Benoist C, Mathis D. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity. 1999 Apr; 10(4):451-61.
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  146. Tourne S, Kouskoff V, Ho W, Davis M, Benoist C, Mathis D. Inhibition of thymocyte positive selection by natural MHC: peptide ligands. Eur J Immunol. 1999 Feb; 29(2):394-402.
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  147. Benoist C, Mathis D. T-cell development: a new marker of differentiation state. Curr Biol. 1999 Jan 28; 9(2):R59-61.
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  148. Höglund P, Mintern J, Waltzinger C, Heath W, Benoist C, Mathis D. Initiation of autoimmune diabetes by developmentally regulated presentation of islet cell antigens in the pancreatic lymph nodes. J Exp Med. 1999 Jan 18; 189(2):331-9.
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  149. André-Schmutz I, Hindelang C, Benoist C, Mathis D. Cellular and molecular changes accompanying the progression from insulitis to diabetes. Eur J Immunol. 1999 Jan; 29(1):245-55.
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  150. Chan S, Correia-Neves M, Dierich A, Benoist C, Mathis D. Visualization of CD4/CD8 T cell commitment. J Exp Med. 1998 Dec 21; 188(12):2321-33.
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  151. Williams GS, Malin M, Vremec D, Chang CH, Boyd R, Benoist C, Mathis D. Mice lacking the transcription factor CIITA--a second look. Int Immunol. 1998 Dec; 10(12):1957-67.
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  152. Williams GS, Oxenius A, Hengartner H, Benoist C, Mathis D. CD4+ T cell responses in mice lacking MHC class II molecules specifically on B cells. Eur J Immunol. 1998 Nov; 28(11):3763-72.
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  153. Chan S, Correia-Neves M, Benoist C, Mathis D. CD4/CD8 lineage commitment: matching fate with competence. Immunol Rev. 1998 Oct; 165:195-207.
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  154. Goula D, Benoist C, Mantero S, Merlo G, Levi G, Demeneix BA. Polyethylenimine-based intravenous delivery of transgenes to mouse lung. Gene Ther. 1998 Sep; 5(9):1291-5.
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  155. Wang B, Gonzalez A, Höglund P, Katz JD, Benoist C, Mathis D. Interleukin-4 deficiency does not exacerbate disease in NOD mice. Diabetes. 1998 Aug; 47(8):1207-11.
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  156. Benoist C, Mathis D. Autoimmunity. The pathogen connection. Nature. 1998 Jul 16; 394(6690):227-8.
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  157. Abdallah B, Goula D, Ghorbel M, Guissouma H, Benoist C, Seugnet I, Demeneix BA. Nonviral gene transfer for studying signaling in comparative developmental biology. Ann N Y Acad Sci. 1998 May 15; 839:87-92.
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  158. Lühder F, Katz J, Benoist C, Mathis D. Major histocompatibility complex class II molecules can protect from diabetes by positively selecting T cells with additional specificities. J Exp Med. 1998 Feb 2; 187(3):379-87.
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  159. Lühder F, Höglund P, Allison JP, Benoist C, Mathis D. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) regulates the unfolding of autoimmune diabetes. J Exp Med. 1998 Feb 2; 187(3):427-32.
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  160. Wang B, André I, Gonzalez A, Katz JD, Aguet M, Benoist C, Mathis D. Interferon-gamma impacts at multiple points during the progression of autoimmune diabetes. Proc Natl Acad Sci U S A. 1997 Dec 9; 94(25):13844-9.
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  161. Gonzalez A, Katz JD, Mattei MG, Kikutani H, Benoist C, Mathis D. Genetic control of diabetes progression. Immunity. 1997 Dec; 7(6):873-83.
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  162. Benoist C, Mathis D. Autoimmune diabetes. Retrovirus as trigger, precipitator or marker? Nature. 1997 Aug 28; 388(6645):833-4.
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  163. Tourne S, Miyazaki T, Wolf P, Ploegh H, Benoist C, Mathis D. Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9255-60.
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  164. Tourne S, Miyazaki T, Oxenius A, Klein L, Fehr T, Kyewski B, Benoist C, Mathis D. Selection of a broad repertoire of CD4+ T cells in H-2Ma0/0 mice. Immunity. 1997 Aug; 7(2):187-95.
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  165. Rooke R, Waltzinger C, Benoist C, Mathis D. Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses. Immunity. 1997 Jul; 7(1):123-34.
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  166. Benoist C, Mathis D. Selection for survival? Science. 1997 Jun 27; 276(5321):2000-1.
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  167. Oxenius A, Bachmann MF, Mathis D, Benoist C, Zinkernagel RM, Hengartner H. Functional in vivo MHC class II loading by endogenously synthesized glycoprotein during viral infection. J Immunol. 1997 Jun 15; 158(12):5717-26.
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  168. Benoist C, Mathis D. Cell death mediators in autoimmune diabetes--no shortage of suspects. Cell. 1997 Apr 4; 89(1):1-3.
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  169. Benoist C, Mathis D. Positive selection of T cells: fastidious or promiscuous? Curr Opin Immunol. 1997 Apr; 9(2):245-9.
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  170. Kouskoff V, Korganow AS, Duchatelle V, Degott C, Benoist C, Mathis D. A new mouse model of rheumatoid arthritis: organ-specific disease provoked by systemic autoimmunity. Ryumachi. 1997 Apr; 37(2):147.
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  171. Nakano N, Rooke R, Benoist C, Mathis D. Positive selection of T cells induced by viral delivery of neopeptides to the thymus. Science. 1997 Jan 31; 275(5300):678-83.
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  172. Kouskoff V, Korganow AS, Duchatelle V, Degott C, Benoist C, Mathis D. Organ-specific disease provoked by systemic autoimmunity. Cell. 1996 Nov 29; 87(5):811-22.
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  173. Abdallah B, Hassan A, Benoist C, Goula D, Behr JP, Demeneix BA. A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine. Hum Gene Ther. 1996 Oct 20; 7(16):1947-54.
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  174. Texidó G, Jacobs H, Meiering M, Kühn R, Roes J, Müller W, Gilfillan S, Fujiwara H, Kikutani H, Yoshida N, Amakawa R, Benoist C, Mathis D, Kishimoto T, Mak TW, Rajewsky K. Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants. Eur J Immunol. 1996 Aug; 26(8):1966-9.
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  175. Wang B, Gonzalez A, Benoist C, Mathis D. The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitus. Eur J Immunol. 1996 Aug; 26(8):1762-9.
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  176. Wang B, Benoist C, Mathis D. The immunosuppressant 15-deoxyspergualin [correction of 1,5-deoxyspergualin] reveals commonality between preT and preB cell differentiation. J Exp Med. 1996 Jun 1; 183(6):2427-36.
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  177. Miyazaki T, Dierich A, Benoist C, Mathis D. LAG-3 is not responsible for selecting T helper cells in CD4-deficient mice. Int Immunol. 1996 May; 8(5):725-9.
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  178. Schwartz B, Benoist C, Abdallah B, Rangara R, Hassan A, Scherman D, Demeneix BA. Gene transfer by naked DNA into adult mouse brain. Gene Ther. 1996 May; 3(5):405-11.
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  179. Miyazaki T, Dierich A, Benoist C, Mathis D. Independent modes of natural killing distinguished in mice lacking Lag3. Science. 1996 Apr 19; 272(5260):405-8.
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  180. André I, Gonzalez A, Wang B, Katz J, Benoist C, Mathis D. Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6):2260-3.
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  181. Miyazaki T, Wolf P, Tourne S, Waltzinger C, Dierich A, Barois N, Ploegh H, Benoist C, Mathis D. Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell. 1996 Feb 23; 84(4):531-41.
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  182. Tourne S, van Santen HM, van Roon M, Berns A, Benoist C, Mathis D, Ploegh H. Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice. Proc Natl Acad Sci U S A. 1996 Feb 20; 93(4):1464-9.
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  183. Battegay M, Bachmann MF, Burhkart C, Viville S, Benoist C, Mathis D, Hengartner H, Zinkernagel RM. Antiviral immune responses of mice lacking MHC class II or its associated invariant chain. Cell Immunol. 1996 Jan 10; 167(1):115-21.
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  184. Nelson CA, Viner N, Young S, Petzold S, Benoist C, Mathis D, Unanue ER. Amino acid residues on the I-Ak alpha-chain required for the binding and stability of two antigenic peptides. J Immunol. 1996 Jan 1; 156(1):176-82.
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  185. Gilfillan S, Benoist C, Mathis D. Mice lacking terminal deoxynucleotidyl transferase: adult mice with a fetal antigen receptor repertoire. Immunol Rev. 1995 Dec; 148:201-19.
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  186. Gilfillan S, Bachmann M, Trembleau S, Adorini L, Kalinke U, Zinkernagel R, Benoist C, Mathis D. Efficient immune responses in mice lacking N-region diversity. Eur J Immunol. 1995 Nov; 25(11):3115-22.
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  187. Cardell S, Tangri S, Chan S, Kronenberg M, Benoist C, Mathis D. CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice. J Exp Med. 1995 Oct 1; 182(4):993-1004.
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  188. Cheroutre H, Holcombe HR, Tangri S, Castaño AR, Teitell M, Miller JE, Cardell S, Benoist C, Mathis D, Huse WD, et al. Antigen-presenting function of the TL antigen and mouse CD1 molecules. Immunol Rev. 1995 Oct; 147:31-52.
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  189. Tourne S, Nakano N, Viville S, Benoist C, Mathis D. The influence of invariant chain on the positive selection of single T cell receptor specificities. Eur J Immunol. 1995 Jul; 25(7):1851-6.
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  190. Katz JD, Benoist C, Mathis D. T helper cell subsets in insulin-dependent diabetes. Science. 1995 May 26; 268(5214):1185-8.
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  191. Kouskoff V, Signorelli K, Benoist C, Mathis D. Cassette vectors directing expression of T cell receptor genes in transgenic mice. J Immunol Methods. 1995 Mar 27; 180(2):273-80.
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  192. Kouskoff V, Vonesch JL, Benoist C, Mathis D. The influence of positive selection on RAG expression in thymocytes. Eur J Immunol. 1995 Jan; 25(1):54-8.
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  193. Flamant F, Demeneix B, Benoist C, Markossian-Belin S, Samarut J. Virofection: a new procedure to achieve stable expression of genes transferred into early embryos. Int J Dev Biol. 1994 Dec; 38(4):751-7.
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  194. Merkenschlager M, Benoist C, Mathis D. Evidence for a single-niche model of positive selection. Proc Natl Acad Sci U S A. 1994 Nov 22; 91(24):11694-8.
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  195. Gilfillan S, Waltzinger C, Benoist C, Mathis D. More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase. Int Immunol. 1994 Nov; 6(11):1681-6.
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  196. Chan SH, Waltzinger C, Baron A, Benoist C, Mathis D. Role of coreceptors in positive selection and lineage commitment. EMBO J. 1994 Oct 3; 13(19):4482-9.
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  197. Merkenschlager M, Benoist C, Mathis D. MHC control of the naive TCR alpha-chain repertoire. J Immunol. 1994 Oct 1; 153(7):3005-13.
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  198. Benoist C, Mathis D. T-cell co-receptors. The end of a frustrating search. Curr Biol. 1994 Sep 1; 4(9):821-3.
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  199. Mantovani R, Li XY, Pessara U, Hooft van Huisjduijnen R, Benoist C, Mathis D. Dominant negative analogs of NF-YA. J Biol Chem. 1994 Aug 12; 269(32):20340-6.
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  200. Chan SH, Benoist C, Mathis D. In favor of the selective model of positive selection. Semin Immunol. 1994 Aug; 6(4):241-8.
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  201. Rosay P, Hergueux J, Benoist C, Mathis D. Graft rejection across transgene-encoded MHC class II molecules. C R Acad Sci III. 1994 Jul; 317(7):639-43.
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  202. Bodmer H, Viville S, Benoist C, Mathis D. Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain. Science. 1994 Mar 4; 263(5151):1284-6.
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  203. Demeneix BA, Abdel-Taweb H, Benoist C, Seugnet I, Behr JP. Temporal and spatial expression of lipospermine-compacted genes transferred into chick embryos in vivo. Biotechniques. 1994 Mar; 16(3):496-501.
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  204. Cardell S, Merkenschlager M, Bodmer H, Chan S, Cosgrove D, Benoist C, Mathis D. The immune system of mice lacking conventional MHC class II molecules. Adv Immunol. 1994; 55:423-40.
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  205. Mathis D, Benoist C. T cell receptor specificity and diabetes in nonobese diabetic mice. Science. 1993 Dec 3; 262(5139):1583; author reply 1584.
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  206. Kouskoff V, Fehling HJ, Lemeur M, Benoist C, Mathis D. A vector driving the expression of foreign cDNAs in the MHC class II-positive cells of transgenic mice. J Immunol Methods. 1993 Dec 3; 166(2):287-91.
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  207. Benoist C, Mathis D. Transgenes and knock-outs in autoimmunity. Curr Opin Immunol. 1993 Dec; 5(6):900-2.
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  208. Katz J, Benoist C, Mathis D. Major histocompatibility complex class I molecules are required for the development of insulitis in non-obese diabetic mice. Eur J Immunol. 1993 Dec; 23(12):3358-60.
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  209. Mantovani R, Tora L, Moncollin V, Egly JM, Benoist C, Mathis D. The major histocompatibility complex (MHC) Ea promoter: sequences and factors at the initiation site. Nucleic Acids Res. 1993 Oct 25; 21(21):4873-8.
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  210. Chan SH, Benoist C, Mathis D. A challenge to the instructive model of positive selection. Immunol Rev. 1993 Oct; 135:119-31.
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  211. Dierich A, Chan SH, Benoist C, Mathis D. Graft rejection by T cells not restricted by conventional major histocompatibility complex molecules. Eur J Immunol. 1993 Oct; 23(10):2725-8.
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  212. Katz JD, Wang B, Haskins K, Benoist C, Mathis D. Following a diabetogenic T cell from genesis through pathogenesis. Cell. 1993 Sep 24; 74(6):1089-100.
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  213. Benoist C, Mathis D. The virtue of complexity. Curr Biol. 1993 Sep 1; 3(9):625-7.
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  214. Gilfillan S, Dierich A, Lemeur M, Benoist C, Mathis D. Mice lacking TdT: mature animals with an immature lymphocyte repertoire. Science. 1993 Aug 27; 261(5125):1175-8.
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  215. Bodmer H, Obert G, Chan S, Benoist C, Mathis D. Environmental modulation of the autonomy of cytotoxic T lymphocytes. Eur J Immunol. 1993 Jul; 23(7):1649-54.
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  216. Bogue M, Mossmann H, Stauffer U, Benoist C, Mathis D. The level of N-region diversity in T cell receptors is not pre-ordained in the stem cell. Eur J Immunol. 1993 May; 23(5):1185-8.
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  217. Chan SH, Cosgrove D, Waltzinger C, Benoist C, Mathis D. Another view of the selective model of thymocyte selection. Cell. 1993 Apr 23; 73(2):225-36.
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  218. Viville S, Neefjes J, Lotteau V, Dierich A, Lemeur M, Ploegh H, Benoist C, Mathis D. Mice lacking the MHC class II-associated invariant chain. Cell. 1993 Feb 26; 72(4):635-48.
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  219. Hergueux J, Bodmer H, Cardell S, Chan SH, Cosgrove D, Benoist C, Mathis D. Knock-out mice: a new tool for transplantation immunologists. Transplant Proc. 1993 Feb; 25(1 Pt 1):30-2.
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  220. Bogue M, Gilfillan S, Benoist C, Mathis D. Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):11011-5.
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  221. Signorelli K, Benoist C, Mathis D. Why is clonal deletion of neonatal thymocytes defective? Eur J Immunol. 1992 Oct; 22(10):2487-93.
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  222. Mantovani R, Pessara U, Tronche F, Li XY, Knapp AM, Pasquali JL, Benoist C, Mathis D. Monoclonal antibodies to NF-Y define its function in MHC class II and albumin gene transcription. EMBO J. 1992 Sep; 11(9):3315-22.
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  223. Cosgrove D, Bodmer H, Bogue M, Benoist C, Mathis D. Evaluation of the functional equivalence of major histocompatibility complex class II A and E complexes. J Exp Med. 1992 Aug 1; 176(2):629-34.
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  224. Cosgrove D, Chan SH, Waltzinger C, Benoist C, Mathis D. The thymic compartment responsible for positive selection of CD4+ T cells. Int Immunol. 1992 Jun; 4(6):707-10.
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  225. Li XY, Hooft van Huijsduijnen R, Mantovani R, Benoist C, Mathis D. Intron-exon organization of the NF-Y genes. Tissue-specific splicing modifies an activation domain. J Biol Chem. 1992 May 5; 267(13):8984-90.
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  226. Benoist C, Mathis D. Generation of the alpha beta T-cell repertoire. Curr Opin Immunol. 1992 Apr; 4(2):156-61.
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  227. Li XY, Mantovani R, Hooft van Huijsduijnen R, Andre I, Benoist C, Mathis D. Evolutionary variation of the CCAAT-binding transcription factor NF-Y. Nucleic Acids Res. 1992 Mar 11; 20(5):1087-91.
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  228. Bogue M, Candéias S, Benoist C, Mathis D. A special repertoire of alpha:beta T cells in neonatal mice. EMBO J. 1991 Dec; 10(12):3647-54.
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  229. Li XY, Mattei MG, Zaleska-Rutczynska Z, Hooft van Huijsduijnen R, Figueroa F, Nadeau J, Benoist C, Mathis D. One subunit of the transcription factor NF-Y maps close to the major histocompatibility complex in murine and human chromosomes. Genomics. 1991 Nov; 11(3):630-4.
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  230. Candéias S, Waltzinger C, Benoist C, Mathis D. The V beta 17+ T cell repertoire: skewed J beta usage after thymic selection; dissimilar CDR3s in CD4+ versus CD8+ cells. J Exp Med. 1991 Nov 1; 174(5):989-1000.
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  231. Cosgrove D, Gray D, Dierich A, Kaufman J, Lemeur M, Benoist C, Mathis D. Mice lacking MHC class II molecules. Cell. 1991 Sep 6; 66(5):1051-66.
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  232. Wei BY, Gervois N, Mer G, Adorini L, Benoist C, Mathis D. Local structure of a peptide contact site on Ak alpha. Int Immunol. 1991 Aug; 3(8):833-7.
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  233. Candéias S, Katz J, Benoist C, Mathis D, Haskins K. Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6167-70.
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  234. Benoist C, Mathis D. Demystification of the alloresponse. Curr Biol. 1991 Jun; 1(3):143-4.
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  235. Viville S, Jongeneel V, Koch W, Mantovani R, Benoist C, Mathis D. The E alpha promoter: a linker-scanning analysis. J Immunol. 1991 May 1; 146(9):3211-7.
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  236. Kouskoff V, Mantovani RM, Candéias SM, Dorn A, Staub A, Lisowska-Grospierre B, Griscelli C, Benoist CO, Mathis DJ. NF-X, a transcription factor implicated in MHC class II gene regulation. J Immunol. 1991 May 1; 146(9):3197-204.
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  237. Dellabona P, Wei BY, Gervois N, Benoist C, Mathis D. A single amino acid substitution in the Ak molecule fortuitously provokes an alloresponse. Eur J Immunol. 1991 Jan; 21(1):209-13.
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  238. Warren AP, Paschedag I, Benoist C, Peccoud J, Mathis D, Thomas DB. Defects in antigen presentation of mutant influenza haemagglutinins are reversed by mutations in the MHC class II molecule. EMBO J. 1990 Dec; 9(12):3849-56.
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  239. Hooft van Huijsduijnen R, Li XY, Black D, Matthes H, Benoist C, Mathis D. Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits. EMBO J. 1990 Oct; 9(10):3119-27.
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  240. Dellabona P, Peccoud J, Kappler J, Marrack P, Benoist C, Mathis D. Superantigens interact with MHC class II molecules outside of the antigen groove. Cell. 1990 Sep 21; 62(6):1115-21.
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  241. Böhme J, Schuhbaur B, Kanagawa O, Benoist C, Mathis D. MHC-linked protection from diabetes dissociated from clonal deletion of T cells. Science. 1990 Jul 20; 249(4966):293-5.
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  242. Fehling HJ, van Ewijk W, Pasquali JL, Waltzinger C, Le Meur M, Gerlinger P, Benoist C, Mathis D. Functional consequences of overexpressed Ia antigens in AK alpha/AK beta transgenic mice. J Immunol. 1990 Apr 15; 144(8):2865-74.
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  243. Benoist C, Mathis D. Regulation of major histocompatibility complex class-II genes: X, Y and other letters of the alphabet. Annu Rev Immunol. 1990; 8:681-715.
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  244. Klein J, Benoist C, David CS, Demant P, Lindahl KF, Flaherty L, Flavell RA, Hämmerling U, Hood LE, Hunt SW, et al. Revised nomenclature of mouse H-2 genes. Immunogenetics. 1990; 32(3):147-9.
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  245. Benoist C, Mathis D. Sperm cells as vectors for transferring DNA into mouse eggs: a breakthrough for immunologists? Immunol Today. 1989 Nov; 10(11):369.
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  246. Fehling HJ, Viville S, van Ewijk W, Benoist C, Mathis D. Fine-tuning of MHC class II gene expression in defined microenvironments. Trends Genet. 1989 Oct; 5(10):342-7.
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  247. Benoist C, Mathis D. Positive selection of the T cell repertoire: where and when does it occur? Cell. 1989 Sep 22; 58(6):1027-33.
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  248. Berg LJ, Pullen AM, Fazekas de St Groth B, Mathis D, Benoist C, Davis MM. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand. Cell. 1989 Sep 22; 58(6):1035-46.
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  249. Reske-Kunz AB, Landais D, Peccoud J, Benoist C, Mathis D. Functional sites on the A alpha-chain. Polymorphic residues involved in antigen presentation to insulin-specific, Ab alpha:Ak beta-restricted T cells. J Immunol. 1989 Sep 1; 143(5):1472-81.
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  250. Rosloniec EF, Vitez LJ, Beck BN, Buerstedde JM, McKean DJ, Landais D, Benoist C, Mathis D, Freed JH. I-Ak polymorphisms define a functionally dominant region for the presentation of hen egg lysozyme peptides. J Immunol. 1989 Jul 1; 143(1):50-8.
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  251. Böhme J, Haskins K, Stecha P, van Ewijk W, LeMeur M, Gerlinger P, Benoist C, Mathis D. Transgenic mice with I-A on islet cells are normoglycemic but immunologically intolerant. Science. 1989 Jun 9; 244(4909):1179-83.
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  252. Pierres M, Marchetto S, Naquet P, Landais D, Peccoud J, Benoist C, Mathis D. I-A alpha polymorphic residues that determine alloreactive T cell recognition. J Exp Med. 1989 May 1; 169(5):1655-68.
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  253. Koch W, Benoist C, Mathis D. Anatomy of a new B-cell-specific enhancer. Mol Cell Biol. 1989 Jan; 9(1):303-11.
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  254. Dorn A, Benoist C, Mathis D. New B-lymphocyte-specific enhancer-binding protein. Mol Cell Biol. 1989 Jan; 9(1):312-20.
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  255. Le Meur M, Waltzinger C, Gerlinger P, Benoist C, Mathis D. Restricted assembly of MHC class II molecules in transgenic mice. J Immunol. 1989 Jan 1; 142(1):323-7.
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  256. Dellabona P, Peccoud J, Benoist C, Mathis D. T-cell recognition of superantigens: inside or outside the groove? Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1:375-81.
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  257. Dorn A, Fehling HJ, Koch W, Le Meur M, Gerlinger P, Benoist C, Mathis D. B-cell control region at the 5' end of a major histocompatibility complex class II gene: sequences and factors. Mol Cell Biol. 1988 Oct; 8(10):3975-87.
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  258. Landais D, Marchetto S, Waltzinger C, Pierres M, Benoist C, Mathis D. Slot-machine mutagenesis of a polymorphic residue on the A kappa alpha-chain. J Immunol. 1988 Jul 15; 141(2):667-71.
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  259. Gerber P, Lang G, Dorn A, Fehling J, Garcin G, Koch W, Waltzinger C, Benoist C, Mathis D. The enhancer in an MHC class II gene, in vitro and in mouso. Biochimie. 1988 Jul; 70(7):919-25.
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  260. Koch W, Candeias S, Guardiola J, Accolla R, Benoist C, Mathis D. An enhancer factor defect in a mutant Burkitt lymphoma cell line. J Exp Med. 1988 Jun 1; 167(6):1781-90.
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  261. van Ewijk W, Ron Y, Monaco J, Kappler J, Marrack P, Le Meur M, Gerlinger P, Durand B, Benoist C, Mathis D. Compartmentalization of MHC class II gene expression in transgenic mice. Cell. 1988 May 6; 53(3):357-70.
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  262. Hooft van Huijsduijnen RA, Bollekens J, Dorn A, Benoist C, Mathis D. Properties of a CCAAT box-binding protein. Nucleic Acids Res. 1987 Sep 25; 15(18):7265-82.
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  263. Dorn A, Bollekens J, Staub A, Benoist C, Mathis D. A multiplicity of CCAAT box-binding proteins. Cell. 1987 Sep 11; 50(6):863-72.
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  264. Dorn A, Durand B, Marfing C, Le Meur M, Benoist C, Mathis D. Conserved major histocompatibility complex class II boxes--X and Y--are transcriptional control elements and specifically bind nuclear proteins. Proc Natl Acad Sci U S A. 1987 Sep; 84(17):6249-53.
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  265. Flood PM, Benoist C, Mathis D, Murphy DB. Altered I-J phenotype in E alpha transgenic mice. Proc Natl Acad Sci U S A. 1986 Nov; 83(21):8308-12.
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  266. Landais D, Waltzinger C, Beck BN, Staub A, McKean DJ, Benoist C, Mathis D. Functional sites on Ia molecules: a molecular dissection of A alpha immunogenicity. Cell. 1986 Oct 24; 47(2):173-81.
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  267. Ayane M, Mengle-Gaw L, McDevitt HO, Benoist C, Mathis D. E alpha u and E beta u chain association: where lies the anomaly? J Immunol. 1986 Aug 1; 137(3):948-51.
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  268. Le Meur M, Gerlinger P, Benoist C, Mathis D. Correcting an immune-response deficiency by creating E alpha gene transgenic mice. Nature. 1985 Jul 4-10; 316(6023):38-42.
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  269. Landais D, Matthes H, Benoist C, Mathis D. A molecular basis for the Ia.2 and Ia.19 antigenic determinants. Proc Natl Acad Sci U S A. 1985 May; 82(9):2930-4.
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  270. Dembic Z, Ayane M, Klein J, Steinmetz M, Benoist CO, Mathis DJ. Inbred and wild mice carry identical deletions in their E alpha MHC genes. EMBO J. 1985 Jan; 4(1):127-31.
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  271. McDevitt HO, Mathis DJ, Benoist C, Kanter MR, Williams VE. Structure, regulatory polymorphisms, and allelic hypervariability regions in murine I-A alpha. Fed Proc. 1984 Dec; 43(15):3021-4.
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  272. Jongstra J, Reudelhuber TL, Oudet P, Benoist C, Chae CB, Jeltsch JM, Mathis DJ, Chambon P. Induction of altered chromatin structures by simian virus 40 enhancer and promoter elements. Nature. 1984 Feb 23-29; 307(5953):708-14.
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  273. Benoist CO, Mathis DJ, Kanter MR, Williams VE, McDevitt HO. Regions of allelic hypervariability in the murine A alpha immune response gene. Cell. 1983 Aug; 34(1):169-77.
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  274. Mathis DJ, Benoist CO, Williams VE, Kanter MR, McDevitt HO. The murine E alpha immune response gene. Cell. 1983 Mar; 32(3):745-54.
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  275. Benoist CO, Mathis DJ, Kanter MR, Williams VE, McDevitt HO. The murine Ia alpha chains, E alpha and A alpha, show a surprising degree of sequence homology. Proc Natl Acad Sci U S A. 1983 Jan; 80(2):534-8.
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  276. Mathis DJ, Benoist C, Williams VE, Kanter M, McDevitt HO. Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes. Proc Natl Acad Sci U S A. 1983 Jan; 80(1):273-7.
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  277. Benoist C, Chambon P. In vivo sequence requirements of the SV40 early promotor region. Nature. 1981 Mar 26; 290(5804):304-10.
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  278. O'Hare K, Benoist C, Breathnach R. Transformation of mouse fibroblasts to methotrexate resistance by a recombinant plasmid expressing a prokaryotic dihydrofolate reductase. Proc Natl Acad Sci U S A. 1981 Mar; 78(3):1527-31.
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  279. Benoist C, Chambon P. Deletions covering the putative promoter region of early mRNAs of simian virus 40 do not abolish T-antigen expression. Proc Natl Acad Sci U S A. 1980 Jul; 77(7):3865-9.
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  280. Benoist C, O'Hare K, Breathnach R, Chambon P. The ovalbumin gene-sequence of putative control regions. Nucleic Acids Res. 1980 Jan 11; 8(1):127-42.
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  281. O'Hare K, Breathnach R, Benoist C, Chambon P. No more than seven interruptions in the ovalbumin gene: comparison of genomic and double-stranded cDNA sequences. Nucleic Acids Res. 1979 Sep 25; 7(2):321-34.
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  282. Gannon F, O'Hare K, Perrin F, LePennec JP, Benoist C, Cochet M, Breathnach R, Royal A, Garapin A, Cami B, Chambon P. Organisation and sequences at the 5' end of a cloned complete ovalbumin gene. Nature. 1979 Mar 29; 278(5703):428-34.
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  283. Breathnach R, Benoist C, O'Hare K, Gannon F, Chambon P. Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc Natl Acad Sci U S A. 1978 Oct; 75(10):4853-7.
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