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Last Name
Institution

Jagesh V. Shah, Ph.D.

TitleAssociate Professor of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Inst of Medicine
Systems Biology - Rm 564
4 Blackfan Cir
Boston MA 02115
Phone617/525-5912
Other Positions
TitleAssociate Professor of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
DivisionRenal


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Prentice-Mott HV, Chang CH, Mahadevan L, Mitchison TJ, Irimia D, Shah JV. Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):21006-11.
    View in: PubMed
  2. Halbritter J, Bizet AA, Schmidts M, Porath JD, Braun DA, Gee HY, McInerney-Leo AM, Krug P, Filhol E, Davis EE, Airik R, Czarnecki PG, Lehman AM, Trnka P, Nitschké P, Bole-Feysot C, Schueler M, Knebelmann B, Burtey S, Szabó AJ, Tory K, Leo PJ, Gardiner B, McKenzie FA, Zankl A, Brown MA, Hartley JL, Maher ER, Li C, Leroux MR, Scambler PJ, Zhan SH, Jones SJ, Kayserili H, Tuysuz B, Moorani KN, Constantinescu A, Krantz ID, Kaplan BS, Shah JV, Hurd TW, Doherty D, Katsanis N, Duncan EL, Otto EA, Beales PL, Mitchison HM, Saunier S, Hildebrandt F. Defects in the IFT-B Component IFT172 Cause Jeune and Mainzer-Saldino Syndromes in Humans. Am J Hum Genet. 2013 Nov 7; 93(5):915-25.
    View in: PubMed
  3. Gaglia G, Guan Y, Shah JV, Lahav G. Activation and control of p53 tetramerization in individual living cells. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15497-501.
    View in: PubMed
  4. Manning DK, Sergeev M, van Heesbeen RG, Wong MD, Oh JH, Liu Y, Henkelman RM, Drummond I, Shah JV, Beier DR. Loss of the ciliary kinase nek8 causes left-right asymmetry defects. J Am Soc Nephrol. 2013 Jan; 24(1):100-12.
    View in: PubMed
  5. Hartlerode AJ, Guan Y, Rajendran A, Ura K, Schotta G, Xie A, Shah JV, Scully R. Impact of Histone H4 Lysine 20 Methylation on 53BP1 Responses to Chromosomal Double Strand Breaks. PLoS One. 2012; 7(11):e49211.
    View in: PubMed
  6. Kops GJ, Shah JV. Connecting up and clearing out: how kinetochore attachment silences the spindle assembly checkpoint. Chromosoma. 2012 Oct; 121(5):509-25.
    View in: PubMed
  7. Boyle PM, Burrill DR, Inniss MC, Agapakis CM, Deardon A, Dewerd JG, Gedeon MA, Quinn JY, Paull ML, Raman AM, Theilmann MR, Wang L, Winn JC, Medvedik O, Schellenberg K, Haynes KA, Viel A, Brenner TJ, Church GM, Shah JV, Silver PA. A BioBrick compatible strategy for genetic modification of plants. J Biol Eng. 2012; 6(1):8.
    View in: PubMed
  8. Czarnecki PG, Shah JV. The ciliary transition zone: from morphology and molecules to medicine. Trends Cell Biol. 2012 Apr; 22(4):201-10.
    View in: PubMed
  9. Saunders TE, Pan KZ, Angel A, Guan Y, Shah JV, Howard M, Chang F. Noise reduction in the intracellular pom1p gradient by a dynamic clustering mechanism. Dev Cell. 2012 Mar 13; 22(3):558-72.
    View in: PubMed
  10. Shah JV. Many defects make a cyst. Cell Cycle. 2012 Jan 1; 11(1):16.
    View in: PubMed
  11. Hagan RS, Manak MS, Buch HK, Meier MG, Meraldi P, Shah JV, Sorger PK. p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment. Mol Biol Cell. 2011 Nov; 22(22):4236-46.
    View in: PubMed
  12. Shah J. Jagesh Shah: a quantitative approach to cell biology. Interview by Caitlin Sedwick. J Cell Biol. 2011 Jun 27; 193(7):1134-5.
    View in: PubMed
  13. AbouAlaiwi WA, Ratnam S, Booth RL, Shah JV, Nauli SM. Endothelial cells from humans and mice with polycystic kidney disease are characterized by polyploidy and chromosome segregation defects through survivin down-regulation. Hum Mol Genet. 2011 Jan 15; 20(2):354-67.
    View in: PubMed
  14. Shah JV. Cells in tight spaces: the role of cell shape in cell function. J Cell Biol. 2010 Oct 18; 191(2):233-6.
    View in: PubMed
  15. Baker NM, Zeitlin SG, Shi LZ, Shah J, Berns MW. Chromosome tips damaged in anaphase inhibit cytokinesis. PLoS One. 2010; 5(8):e12398.
    View in: PubMed
  16. Hardwick KG, Shah JV. Spindle checkpoint silencing: ensuring rapid and concerted anaphase onset. F1000 Biol Rep. 2010; 2:55.
    View in: PubMed
  17. Zhang J, Wu M, Wang S, Shah JV, Wilson PD, Zhou J. Polycystic kidney disease protein fibrocystin localizes to the mitotic spindle and regulates spindle bipolarity. Hum Mol Genet. 2010 Sep 1; 19(17):3306-19.
    View in: PubMed
  18. Yang L, Besschetnova TY, Brooks CR, Shah JV, Bonventre JV. Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury. Nat Med. 2010 May; 16(5):535-43, 1p following 143.
    View in: PubMed
  19. Kops GJ, van der Voet M, van der Voet M, Manak MS, van Osch MH, Naini SM, Brear A, McLeod IX, Hentschel DM, Yates JR, van den Heuvel S, Shah JV. APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome. J Cell Sci. 2010 May 15; 123(Pt 10):1623-33.
    View in: PubMed
  20. Kwiatkowski N, Jelluma N, Filippakopoulos P, Soundararajan M, Manak MS, Kwon M, Choi HG, Sim T, Deveraux QL, Rottmann S, Pellman D, Shah JV, Kops GJ, Knapp S, Gray NS. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol. 2010 May; 6(5):359-68.
    View in: PubMed
  21. Albrecht DR, Underhill GH, Resnikoff J, Mendelson A, Bhatia SN, Shah JV. Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics. Integr Biol (Camb). 2010 Jun; 2(5-6):278-87.
    View in: PubMed
  22. Besschetnova TY, Kolpakova-Hart E, Guan Y, Zhou J, Olsen BR, Shah JV. Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation. Curr Biol. 2010 Jan 26; 20(2):182-7.
    View in: PubMed
  23. Besschetnova TY, Roy B, Shah JV. Imaging intraflagellar transport in mammalian primary cilia. Methods Cell Biol. 2009; 93:331-46.
    View in: PubMed
  24. Kong T, Xu D, Yu W, Takakura A, Boucher I, Tran M, Kreidberg JA, Shah J, Zhou J, Denker BM. G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis. Mol Biol Cell. 2009 Nov; 20(21):4596-610.
    View in: PubMed
  25. Ciliberto A, Shah JV. A quantitative systems view of the spindle assembly checkpoint. EMBO J. 2009 Aug 5; 28(15):2162-73.
    View in: PubMed
  26. Tran PV, Haycraft CJ, Besschetnova TY, Turbe-Doan A, Stottmann RW, Herron BJ, Chesebro AL, Qiu H, Scherz PJ, Shah JV, Yoder BK, Beier DR. THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nat Genet. 2008 Apr; 40(4):403-10.
    View in: PubMed
  27. Sabath E, Negoro H, Beaudry S, Paniagua M, Angelow S, Shah J, Grammatikakis N, Yu AS, Denker BM. Galpha12 regulates protein interactions within the MDCK cell tight junction and inhibits tight-junction assembly. J Cell Sci. 2008 Mar 15; 121(Pt 6):814-24.
    View in: PubMed
  28. Black BE, Jansen LE, Maddox PS, Foltz DR, Desai AB, Shah JV, Cleveland DW. Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain. Mol Cell. 2007 Jan 26; 25(2):309-22.
    View in: PubMed
  29. Botvinick EL, Shah JV. Laser-based measurements in cell biology. Methods Cell Biol. 2007; 82:81-109.
    View in: PubMed
  30. Wang Z, Shah JV, Berns MW, Cleveland DW. In vivo quantitative studies of dynamic intracellular processes using fluorescence correlation spectroscopy. Biophys J. 2006 Jul 1; 91(1):343-51.
    View in: PubMed
  31. Bomont P, Maddox P, Shah JV, Desai AB, Cleveland DW. Unstable microtubule capture at kinetochores depleted of the centromere-associated protein CENP-F. EMBO J. 2005 Nov 16; 24(22):3927-39.
    View in: PubMed
  32. Botvinick EL, Venugopalan V, Shah JV, Liaw LH, Berns MW. Controlled ablation of microtubules using a picosecond laser. Biophys J. 2004 Dec; 87(6):4203-12.
    View in: PubMed
  33. Shah JV, Botvinick E, Bonday Z, Furnari F, Berns M, Cleveland DW. Dynamics of centromere and kinetochore proteins; implications for checkpoint signaling and silencing. Curr Biol. 2004 Jun 8; 14(11):942-52.
    View in: PubMed
  34. Wang Z, Shah JV, Chen Z, Sun CH, Berns MW. Fluorescence correlation spectroscopy investigation of a GFP mutant-enhanced cyan fluorescent protein and its tubulin fusion in living cells with two-photon excitation. J Biomed Opt. 2004 Mar-Apr; 9(2):395-403.
    View in: PubMed
  35. Shah JV, Cleveland DW. Slow axonal transport: fast motors in the slow lane. Curr Opin Cell Biol. 2002 Feb; 14(1):58-62.
    View in: PubMed
  36. Tang JX, Käs JA, Shah JV, Janmey PA. Counterion-induced actin ring formation. Eur Biophys J. 2001 Dec; 30(7):477-84.
    View in: PubMed
  37. Janmey PA, Shah JV, Tang JX, Stossel TP. Actin filament networks. Results Probl Cell Differ. 2001; 32:181-99.
    View in: PubMed
  38. Shah JV, Cleveland DW. Waiting for anaphase: Mad2 and the spindle assembly checkpoint. Cell. 2000 Dec 22; 103(7):997-1000.
    View in: PubMed
  39. Shah JV, Flanagan LA, Janmey PA, Leterrier JF. Bidirectional translocation of neurofilaments along microtubules mediated in part by dynein/dynactin. Mol Biol Cell. 2000 Oct; 11(10):3495-508.
    View in: PubMed
  40. Shah JV, Goldstein LS. Does motor protein intelligence contribute to neuronal polarity? Neuron. 2000 May; 26(2):281-2.
    View in: PubMed
  41. Allen PG, Shah JV. Brains and brawn: plectin as regulator and reinforcer of the cytoskeleton. Bioessays. 1999 Jun; 21(6):451-4.
    View in: PubMed
  42. Shah JV, Poon CS. Linear independence of internal representations in multilayer perceptrons. IEEE Trans Neural Netw. 1999; 10(1):10-8.
    View in: PubMed
  43. Shah JV, Wang LZ, Traub P, Janmey PA. Interaction of vimentin with actin and phospholipids. Biol Bull. 1998 Jun; 194(3):402-5.
    View in: PubMed
  44. Janmey PA, Kas J, Shah JV, Allen PG, Tang JX. Cytoskeletal networks and filament bundles: regulation by proteins and polycations. Biol Bull. 1998 Jun; 194(3):334-5; discussion 335-6.
    View in: PubMed
  45. Poon CS, Shah JV. Hebbian learning in parallel and modular memories. Biol Cybern. 1998 Feb; 78(2):79-86.
    View in: PubMed
  46. Janmey PA, Shah JV, Janssen KP, Schliwa M. Viscoelasticity of intermediate filament networks. Subcell Biochem. 1998; 31:381-97.
    View in: PubMed
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