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Elizabeth Beryl Klerman, PH.D., M.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham & Women's Hospital
Sleep Medicine/Med, BL 427A
221 Longwood Ave
Boston MA 02115
Phone617/732-8145
Fax617/732-4015

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Phillips AJ, Fulcher BD, Robinson PA, Klerman EB. Mammalian rest/activity patterns explained by physiologically based modeling. PLoS Comput Biol. 2013 Sep; 9(9):e1003213.
    View in: PubMed
  2. Breslow ER, Phillips AJ, Huang JM, St Hilaire MA, Klerman EB. A mathematical model of the circadian phase-shifting effects of exogenous melatonin. J Biol Rhythms. 2013 Feb; 28(1):79-89.
    View in: PubMed
  3. Phillips AJ, Robinson PA, Klerman EB. Arousal state feedback as a potential physiological generator of the ultradian REM/NREM sleep cycle. J Theor Biol. 2013 Feb 21; 319:75-87.
    View in: PubMed
  4. Bianchi MT, Wang W, Klerman EB. Sleep misperception in healthy adults: implications for insomnia diagnosis. J Clin Sleep Med. 2012; 8(5):547-54.
    View in: PubMed
  5. St Hilaire MA, Sullivan JP, Anderson C, Cohen DA, Barger LK, Lockley SW, Klerman EB. Classifying performance impairment in response to sleep loss using pattern recognition algorithms on single session testing. Accid Anal Prev. 2013 Jan; 50:992-1002.
    View in: PubMed
  6. Klerman EB, Wang W, Duffy JF, Dijk DJ, Czeisler CA, Kronauer RE. Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep. Neurobiol Aging. 2013 Jan; 34(1):309-18.
    View in: PubMed
  7. Klerman H, St Hilaire MA, Kronauer RE, Gooley JJ, Gronfier C, Hull JT, Lockley SW, Santhi N, Wang W, Klerman EB. Analysis method and experimental conditions affect computed circadian phase from melatonin data. PLoS One. 2012; 7(4):e33836.
    View in: PubMed
  8. Phillips AJ, Czeisler CA, Klerman EB. Revisiting spontaneous internal desynchrony using a quantitative model of sleep physiology. J Biol Rhythms. 2011 Oct; 26(5):441-53.
    View in: PubMed
  9. Klingman KM, Marsh EE, Klerman EB, Anderson EJ, Hall JE. Absence of circadian rhythms of gonadotropin secretion in women. J Clin Endocrinol Metab. 2011 May; 96(5):1456-61.
    View in: PubMed
  10. Citi L, Bianchi MT, Klerman EB, Barbieri R. Instantaneous monitoring of sleep fragmentation by point process heart rate variability and respiratory dynamics. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:7735-8.
    View in: PubMed
  11. Cohen DA, Wang W, Klerman EB, Rajaratnam SM. Ramelteon prior to a short evening nap impairs neurobehavioral performance for up to 12 hours after awakening. J Clin Sleep Med. 2010 Dec 15; 6(6):565-71.
    View in: PubMed
  12. Diniz Behn CG, Klerman EB, Mochizuki T, Lin SC, Scammell TE. Abnormal sleep/wake dynamics in orexin knockout mice. Sleep. 2010 Mar; 33(3):297-306.
    View in: PubMed
  13. Cohen DA, Wang W, Wyatt JK, Kronauer RE, Dijk DJ, Czeisler CA, Klerman EB. Uncovering residual effects of chronic sleep loss on human performance. Sci Transl Med. 2010 Jan 13; 2(14):14ra3.
    View in: PubMed
  14. Dean DA, Forger DB, Klerman EB. Taking the lag out of jet lag through model-based schedule design. PLoS Comput Biol. 2009 Jun; 5(6):e1000418.
    View in: PubMed
  15. Rajaratnam SM, Polymeropoulos MH, Fisher DM, Roth T, Scott C, Birznieks G, Klerman EB. Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials. Lancet. 2009 Feb 7; 373(9662):482-91.
    View in: PubMed
  16. Klerman EB, Dijk DJ. Age-related reduction in the maximal capacity for sleep--implications for insomnia. Curr Biol. 2008 Aug 5; 18(15):1118-23.
    View in: PubMed
  17. Benloucif S, Burgess HJ, Klerman EB, Lewy AJ, Middleton B, Murphy PJ, Parry BL, Revell VL. Measuring melatonin in humans. J Clin Sleep Med. 2008 Feb 15; 4(1):66-9.
    View in: PubMed
  18. St Hilaire MA, Gronfier C, Zeitzer JM, Klerman EB. A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker. J Pineal Res. 2007 Oct; 43(3):294-304.
    View in: PubMed
  19. Kronauer RE, Gunzelmann G, Van Dongen HP, Doyle FJ, Klerman EB. Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation through mathematical modeling. J Biol Rhythms. 2007 Jun; 22(3):233-45.
    View in: PubMed
  20. Dean DA, Fletcher A, Hursh SR, Klerman EB. Developing mathematical models of neurobehavioral performance for the "real world". J Biol Rhythms. 2007 Jun; 22(3):246-58.
    View in: PubMed
  21. St Hilaire MA, Klerman EB, Khalsa SB, Wright KP, Czeisler CA, Kronauer RE. Addition of a non-photic component to a light-based mathematical model of the human circadian pacemaker. J Theor Biol. 2007 Aug 21; 247(4):583-99.
    View in: PubMed
  22. Klerman EB, St Hilaire M. On mathematical modeling of circadian rhythms, performance, and alertness. J Biol Rhythms. 2007 Apr; 22(2):91-102.
    View in: PubMed
  23. St. Hilaire MA, Klerman EB. Inter-individual variability in the parameters of a mathematical model of neurobehavioral performance and alertness. Sleep. 2007; 30:A52.
  24. Mochizuki T, Klerman EB, Sakurai T, Scammell TE. Elevated body temperature during sleep in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol. 2006 Sep; 291(3):R533-40.
    View in: PubMed
  25. Indic P, Gurdziel K, Kronauer RE, Klerman EB. Development of a two-dimension manifold to represent high dimension mathematical models of the intracellular Mammalian circadian clock. J Biol Rhythms. 2006 Jun; 21(3):222-32.
    View in: PubMed
  26. St. Hilaire MA, Gronfier C, Klerman EB. Addition of a light effect to a physiologically-based model of melatonin. Society for Research in Biological Rhythms biannual meeting. 2006; 8:153.
  27. Rajaratnam SMW, Polymeropoulos MH, Fisher DM, Scott CH, Birznieks G, Klerman EB. Phase-advancing human circadian rhythms with the dual MT1/MT2 melatonin agonist VEC-162. Society for Research in Biological Rhythms biannual meeting. 2006; 8:66.
  28. Rajaratnam SMW, Ronda JM, Polymeropoulos MH, Fisher DM, Scott CH, Birznieks G, Klerman EB. The melatonin agonist VEC-162 immediately phase-advances the human circadian system. Sleep. 2006; (in press).
  29. Dean II DA, Klerman EB, Barger LK, Livingston G. Understanding Bayesian network structure sensitivity in classifiers derived from human experimental data. Life Science Society Computational Systems Bioinformatics Conference. 2006; (in press).
  30. Klerman EB, Dijk DJ. Aging: Asymptotic sleep duration during extended sleep opportunities. Sleep. 2006; 19:A35.
  31. Hall JE, Dean DA, Smith PC, Klerman EB. Sleep attenuates LH/GnRH pulse frequency in the luteal as well as the early follicular phase in normal women. Endocrine Society Annual Meeting. 2006; #853816.
  32. Klerman EB, Dijk DJ. Aging: Changes in mood and performance during sleep extension in younger and older people. Sleep. 2006; 29:A374.
  33. Dean II DA, Barger LK, Livingston G, Czeisler CA, Klerman EB. Using Bayesian networks to understand individual differences that affect the use of actigraphy as a predictor of sleep. Sleep. 2006; 29:A69.
  34. Klerman EB, Dean DA, Smith PC, Hall JE. The relationship between LH interpulse interval and amplitude in influenced by cycle phase, but not by sleep in adult women. Society for Research in Biological Rhythms biannual meeting. 2006; 8:49.
  35. St. Hilaire MA, Klerman EB. A tool to analyze melatonin phase and amplitude using a physiologically-based model of melatonin. Sleep. 2006; 19:A53-A54.
  36. Klerman EB, Dijk DJ. Interindividual variation in sleep duration and its association with sleep debt in young adults. Sleep. 2005 Oct; 28(10):1253-9.
    View in: PubMed
  37. Klerman EB. Clinical aspects of human circadian rhythms. J Biol Rhythms. 2005 Aug; 20(4):375-86.
    View in: PubMed
  38. Dean DA, Forger DB, Klerman EB. Designing optimal light intervention schedules for experimental and operational settings. Sleep. 2005; 28:A69.
  39. Dean DA, Klerman EB. Using domain specific information to design optimal circadian adjustment schedules. Computation Physiology: from Genome to Physiom Symposium, 35th International Congress of Physiological Sciences. 2005.
  40. Indic P, Forger DB, St Hilaire MA, Dean DA, Brown EN, Kronauer RE, Klerman EB, Jewett ME. Comparison of amplitude recovery dynamics of two limit cycle oscillator models of the human circadian pacemaker. Chronobiol Int. 2005; 22(4):613-29.
    View in: PubMed
  41. St. Hilaire MA, Klerman EB, Lockley SW, Brainard GC, Kronauer RE. Revision of a mathematical model of circadian photic resetting to incorporate spectral sensitivity. Sleep. 2005; 28:A56.
  42. Klerman EB, Davis JB, Duffy JF, Dijk DJ, Kronauer RE. Older people awaken more frequently but fall back asleep at the same rate as younger people. Sleep. 2004 Jun 15; 27(4):793-8.
    View in: PubMed
  43. Gurdziel K, Kronauer RE, Shiromani PJ, Klerman EB. Age related differences in sleep state transitions and transition duration in rats before and after sleep deprivation. Sleep. 2004; A140.
  44. Klerman EB, Dijk DJ. Regulation of sleep during the day and at night during a bedrest extension protocol in older and younger individuals. Society for Research on Biological Rhythms. 2004; 9:190-191.
  45. Mazza MC, Dijk DJ, Klerman EB. Alertness and performance in older and younger adults during 16, 28, and 52 hours of sleep deprivation. Sleep. 2004; A154-155.
  46. Klerman EB, Hall JE. Sleep related slowing of LH pulses in the luteal phase of the menstrual cycle. Sleep. 2004; A40.
  47. Klerman EB, Hall JE. Differential effect of sleep disruption on menstrual cycle dynamics. Society for Research on Biological Rhythms. 2004; 9:46.
  48. Klerman EB, Dijk D-J. Sleep during a bedrest extension protocol in older and younger individuals. Sleep. 2004; A129-130.
  49. Dean DA, Mazza MC, Wyatt JK, Czeisler CA, Klerman EB. Circadian and homeostatic components of mathematical models of neurobehavioral performance for the effects of low dose caffeine during a 42-hour forced desynchrony protocol. Sleep. 2004; A77-78.
  50. Klerman EB, Adler GK, Jin M, Maliszewski AM, Brown EN. A statistical model of diurnal variation in human growth hormone. Am J Physiol Endocrinol Metab. 2003 Nov; 285(5):E1118-26.
    View in: PubMed
  51. Klerman EB, Shanahan TL, Brotman DJ, Rimmer DW, Emens JS, Rizzo JF, Czeisler CA. Photic resetting of the human circadian pacemaker in the absence of conscious vision. J Biol Rhythms. 2002 Dec; 17(6):548-55.
    View in: PubMed
  52. Klerman EB, Gershengorn HB, Duffy JF, Kronauer RE. Comparisons of the variability of three markers of the human circadian pacemaker. J Biol Rhythms. 2002 Apr; 17(2):181-93.
    View in: PubMed
  53. Duffy JF, Zeitzer JM, Rimmer DW, Klerman EB, Dijk DJ, Czeisler CA. Peak of circadian melatonin rhythm occurs later within the sleep of older subjects. Am J Physiol Endocrinol Metab. 2002 Feb; 282(2):E297-303.
    View in: PubMed
  54. Klerman EB, Zeitzer JM, Duffy JF, Khalsa SB, Czeisler CA. Absence of an increase in the duration of the circadian melatonin secretory episode in totally blind human subjects. J Clin Endocrinol Metab. 2001 Jul; 86(7):3166-70.
    View in: PubMed
  55. Klerman EB, Goldenberg DL, Brown EN, Maliszewski AM, Adler GK. Circadian rhythms of women with fibromyalgia. J Clin Endocrinol Metab. 2001 Mar; 86(3):1034-9.
    View in: PubMed
  56. Klerman EB. Non-photic effects on the circadian system: results from experiements in blind and sighted individuals. Zeitgebers, Entrainment and Masking of the Circadian System. Honma K, Honma S, eds. 2001; 155-169.
  57. Klerman EB, Duffy JF, Dijk DJ, Czeisler CA. Circadian phase resetting in older people by ocular bright light exposure. J Investig Med. 2001 Jan; 49(1):30-40.
    View in: PubMed
  58. Klerman EB, Boulos Z, Edgar DM, Mistlberger RE, Moore-Ede MC. EEG delta activity during undisturbed sleep in the squirrel monkey. Sleep Res Online. 2000; 3(3):113-9.
    View in: PubMed
  59. Klerman EB, Jewett ME. Commentary: model building, quantitative testing, and model comparison. J Biol Rhythms. 1999 Dec; 14(6):621-4.
    View in: PubMed
  60. Zeitzer JM, Daniels JE, Duffy JF, Klerman EB, Shanahan TL, Dijk DJ, Czeisler CA. Do plasma melatonin concentrations decline with age? Am J Med. 1999 Nov; 107(5):432-6.
    View in: PubMed
  61. Klerman EB, Lee Y, Czeisler CA, Kronauer RE. Linear demasking techniques are unreliable for estimating the circadian phase of ambulatory temperature data. J Biol Rhythms. 1999 Aug; 14(4):260-74.
    View in: PubMed
  62. Klerman EB, Boulos Z, Edgar DM, Mistlberger RE, Moore-Ede MC. Circadian and homeostatic influences on sleep in the squirrel monkey: sleep after sleep deprivation. Sleep. 1999 Feb 1; 22(1):45-59.
    View in: PubMed
  63. Czeisler CA, Klerman EB. Circadian and sleep-dependent regulation of hormone release in humans. Recent Prog Horm Res. 1999; 54:97-130; discussion 130-2.
    View in: PubMed
  64. Duffy JF, Dijk DJ, Klerman EB, Czeisler CA. Later endogenous circadian temperature nadir relative to an earlier wake time in older people. Am J Physiol. 1998 Nov; 275(5 Pt 2):R1478-87.
    View in: PubMed
  65. Klerman EB, Rimmer DW, Dijk DJ, Kronauer RE, Rizzo JF, Czeisler CA. Nonphotic entrainment of the human circadian pacemaker. Am J Physiol. 1998 Apr; 274(4 Pt 2):R991-6.
    View in: PubMed
  66. Jewett ME, Rimmer DW, Duffy JF, Klerman EB, Kronauer RE, Czeisler CA. Human circadian pacemaker is sensitive to light throughout subjective day without evidence of transients. Am J Physiol. 1997 Nov; 273(5 Pt 2):R1800-9.
    View in: PubMed
  67. el-Hajj Fuleihan G, Klerman EB, Brown EN, Choe Y, Brown EM, Czeisler CA. The parathyroid hormone circadian rhythm is truly endogenous--a general clinical research center study. J Clin Endocrinol Metab. 1997 Jan; 82(1):281-6.
    View in: PubMed
  68. Klerman EB, Dijk DJ, Kronauer RE, Czeisler CA. Simulations of light effects on the human circadian pacemaker: implications for assessment of intrinsic period. Am J Physiol. 1996 Jan; 270(1 Pt 2):R271-82.
    View in: PubMed
  69. Czeisler CA, Shanahan TL, Klerman EB, Martens H, Brotman DJ, Emens JS, Klein T, Rizzo JF. Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med. 1995 Jan 5; 332(1):6-11.
    View in: PubMed
  70. Klerman EB. Selective NREM Sleep Deprivation. Carskadon MA, editor. Encyclopedia of Sleep and Dreaming. 1993; 177-178.
  71. Klerman EB. Circadian and Homeostatic Regulation of Sleep in the Squirrel Monkey. 1990.
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