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Keywords
Last Name
Institution

Andrzej Stefan Krolewski, PH.D., M.D.

TitleProfessor of Medicine
InstitutionJoslin Diabetes Center
DepartmentMedicine
AddressJoslin Diabetes Center
One Joslin Place
Boston MA 02215
Phone617/732-2668
Fax617/732-2667

 Mentoring 
 completed student projects
The Role of Carboxypeptidase A in Conferring Susceptibility to Diabetic Nephropathy in Type I Diabetics
Summer, 06/21/99 - 08/21/99

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pezzolesi MG, Krolewski AS. Diabetic nephropathy: is ESRD its only heritable phenotype? J Am Soc Nephrol. 2013 Oct; 24(10):1505-7.
    View in: PubMed
  2. Qi L, Qi Q, Prudente S, Mendonca C, Andreozzi F, di Pietro N, Sturma M, Novelli V, Mannino GC, Formoso G, Gervino EV, Hauser TH, Muehlschlegel JD, Niewczas MA, Krolewski AS, Biolo G, Pandolfi A, Rimm E, Sesti G, Trischitta V, Hu F, Doria A. Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes. JAMA. 2013 Aug 28; 310(8):821-8.
    View in: PubMed
  3. Krolewski AS, Niewczas MA, Skupien J, Gohda T, Smiles A, Eckfeldt JH, Doria A, Warram JH. Early progressive renal decline precedes the onset of microalbuminuria and its progression to macroalbuminuria. Diabetes Care. 2014 Jan; 37(1):226-34.
    View in: PubMed
  4. Skupien J, Warram JH, Groop PH, Krolewski AS. Cystatin-Based Estimated GFR Versus Creatinine-Based and Creatinine- and Cystatin-Based Estimated GFR for ESRD and Mortality Risk in Diabetes. Am J Kidney Dis. 2013 Jul; 62(1):184-6.
    View in: PubMed
  5. Pezzolesi MG, Jeong J, Smiles AM, Skupien J, Mychaleckyj JC, Rich SS, Warram JH, Krolewski AS. Family-based association analysis confirms the role of the chromosome 9q21.32 locus in the susceptibility of diabetic nephropathy. PLoS One. 2013; 8(3):e60301.
    View in: PubMed
  6. Lee JE, Gohda T, Walker WH, Skupien J, Smiles AM, Holak RR, Jeong J, McDonnell KP, Krolewski AS, Niewczas MA. Risk of ESRD and All Cause Mortality in Type 2 Diabetes According to Circulating Levels of FGF-23 and TNFR1. PLoS One. 2013; 8(3):e58007.
    View in: PubMed
  7. Wanic K, Krolewski B, Ju W, Placha G, Niewczas MA, Walker W, Warram JH, Kretzler M, Krolewski AS. Transcriptome Analysis of Proximal Tubular Cells (HK-2) Exposed to Urines of Type 1 Diabetes Patients at Risk of Early Progressive Renal Function Decline. PLoS One. 2013; 8(3):e57751.
    View in: PubMed
  8. Merchant ML, Niewczas MA, Ficociello LH, Lukenbill JA, Wilkey DW, Li M, Khundmiri SJ, Warram JH, Krolewski AS, Klein JB. Plasma kininogen and kininogen fragments are biomarkers of progressive renal decline in type 1 diabetes. Kidney Int. 2013 Jun; 83(6):1177-84.
    View in: PubMed
  9. Martini S, Nair V, Patel SR, Eichinger F, Nelson RG, Weil EJ, Pezzolesi MG, Krolewski AS, Randolph A, Keller BJ, Werner T, Kretzler M. From Single Nucleotide Polymorphism to Transcriptional Mechanism: A Model for FRMD3 in Diabetic Nephropathy. Diabetes. 2013 Jul; 62(7):2605-12.
    View in: PubMed
  10. Pezzolesi MG, Krolewski AS. The genetic risk of kidney disease in type 2 diabetes. Med Clin North Am. 2013 Jan; 97(1):91-107.
    View in: PubMed
  11. Krolewski AS, Bonventre JV. High risk of ESRD in type 1 diabetes: new strategies are needed to retard progressive renal function decline. Semin Nephrol. 2012 Sep; 32(5):407-14.
    View in: PubMed
  12. Krolewski AS, Bonventre JV. High risk of ESRD in type 1 diabetes: call for action: introduction. Semin Nephrol. 2012 Sep; 32(5):405-6.
    View in: PubMed
  13. Krolewski AS, Warram JH, Forsblom C, Smiles AM, Thorn L, Skupien J, Harjutsalo V, Stanton R, Eckfeldt JH, Inker LA, Groop PH. Serum concentration of cystatin C and risk of end-stage renal disease in diabetes. Diabetes Care. 2012 Nov; 35(11):2311-6.
    View in: PubMed
  14. Skupien J, Warram JH, Smiles AM, Niewczas MA, Gohda T, Pezzolesi MG, Cantarovich D, Stanton R, Krolewski AS. The early decline in renal function in patients with type 1 diabetes and proteinuria predicts the risk of end-stage renal disease. Kidney Int. 2012 Sep; 82(5):589-97.
    View in: PubMed
  15. Perkins BA, Rabbani N, Weston A, Ficociello LH, Adaikalakoteswari A, Niewczas M, Warram J, Krolewski AS, Thornalley P. Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes. PLoS One. 2012; 7(4):e35655.
    View in: PubMed
  16. Gohda T, Walker WH, Wolkow P, Lee JE, Warram JH, Krolewski AS, Niewczas MA. Elevated urinary excretion of immunoglobulins in nonproteinuric patients with type 1 diabetes. Am J Physiol Renal Physiol. 2012 Jul 1; 303(1):F157-62.
    View in: PubMed
  17. Niewczas MA, Gohda T, Skupien J, Smiles AM, Walker WH, Rosetti F, Cullere X, Eckfeldt JH, Doria A, Mayadas TN, Warram JH, Krolewski AS. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol. 2012 Mar; 23(3):507-15.
    View in: PubMed
  18. Gohda T, Niewczas MA, Ficociello LH, Walker WH, Skupien J, Rosetti F, Cullere X, Johnson AC, Crabtree G, Smiles AM, Mayadas TN, Warram JH, Krolewski AS. Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol. 2012 Mar; 23(3):516-24.
    View in: PubMed
  19. Doria A, Krolewski AS. Diabetes: Lowering serum uric acid levels to prevent kidney failure. Nat Rev Nephrol. 2011 Sep; 7(9):495-6.
    View in: PubMed
  20. Pezzolesi MG, Poznik GD, Skupien J, Smiles AM, Mychaleckyj JC, Rich SS, Warram JH, Krolewski AS. An intergenic region on chromosome 13q33.3 is associated with the susceptibility to kidney disease in type 1 and 2 diabetes. Kidney Int. 2011 Jul; 80(1):105-11.
    View in: PubMed
  21. Rosolowsky ET, Skupien J, Smiles AM, Niewczas M, Roshan B, Stanton R, Eckfeldt JH, Warram JH, Krolewski AS. Risk for ESRD in type 1 diabetes remains high despite renoprotection. J Am Soc Nephrol. 2011 Mar; 22(3):545-53.
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  22. Kure M, Pezzolesi MG, Poznik GD, Katavetin P, Skupien J, Dunn JS, Mychaleckyj JC, Warram JH, Krolewski AS. Genetic variation in the matrix metalloproteinase genes and diabetic nephropathy in type 1 diabetes. Mol Genet Metab. 2011 May; 103(1):60-5.
    View in: PubMed
  23. Vaidya VS, Niewczas MA, Ficociello LH, Johnson AC, Collings FB, Warram JH, Krolewski AS, Bonventre JV. Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-ß-D-glucosaminidase. Kidney Int. 2011 Feb; 79(4):464-70.
    View in: PubMed
  24. Good DM, Zürbig P, Argilés A, Bauer HW, Behrens G, Coon JJ, Dakna M, Decramer S, Delles C, Dominiczak AF, Ehrich JH, Eitner F, Fliser D, Frommberger M, Ganser A, Girolami MA, Golovko I, Gwinner W, Haubitz M, Herget-Rosenthal S, Jankowski J, Jahn H, Jerums G, Julian BA, Kellmann M, Kliem V, Kolch W, Krolewski AS, Luppi M, Massy Z, Melter M, Neusüss C, Novak J, Peter K, Rossing K, Rupprecht H, Schanstra JP, Schiffer E, Stolzenburg JU, Tarnow L, Theodorescu D, Thongboonkerd V, Vanholder R, Weissinger EM, Mischak H, Schmitt-Kopplin P. Naturally occurring human urinary peptides for use in diagnosis of chronic kidney disease. Mol Cell Proteomics. 2010 Nov; 9(11):2424-37.
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  25. Liew CW, Bochenski J, Kawamori D, Hu J, Leech CA, Wanic K, Malecki M, Warram JH, Qi L, Krolewski AS, Kulkarni RN. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells. J Clin Invest. 2010 Aug; 120(8):2876-88.
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  26. Ficociello LH, Rosolowsky ET, Niewczas MA, Maselli NJ, Weinberg JM, Aschengrau A, Eckfeldt JH, Stanton RC, Galecki AT, Doria A, Warram JH, Krolewski AS. High-normal serum uric acid increases risk of early progressive renal function loss in type 1 diabetes: results of a 6-year follow-up. Diabetes Care. 2010 Jun; 33(6):1337-43.
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  27. Pezzolesi MG, Skupien J, Mychaleckyj JC, Warram JH, Krolewski AS. Insights to the genetics of diabetic nephropathy through a genome-wide association study of the GoKinD collection. Semin Nephrol. 2010 Mar; 30(2):126-40.
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  28. Perkins BA, Ficociello LH, Roshan B, Warram JH, Krolewski AS. In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria. Kidney Int. 2010 Jan; 77(1):57-64.
    View in: PubMed
  29. Tsaih SW, Pezzolesi MG, Yuan R, Warram JH, Krolewski AS, Korstanje R. Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan. Kidney Int. 2010 Feb; 77(3):201-10.
    View in: PubMed
  30. Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14460-5.
    View in: PubMed
  31. Pezzolesi MG, Katavetin P, Kure M, Poznik GD, Skupien J, Mychaleckyj JC, Rich SS, Warram JH, Krolewski AS. Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy. Diabetes. 2009 Nov; 58(11):2698-702.
    View in: PubMed
  32. Merchant ML, Perkins BA, Boratyn GM, Ficociello LH, Wilkey DW, Barati MT, Bertram CC, Page GP, Rovin BH, Warram JH, Krolewski AS, Klein JB. Urinary peptidome may predict renal function decline in type 1 diabetes and microalbuminuria. J Am Soc Nephrol. 2009 Sep; 20(9):2065-74.
    View in: PubMed
  33. Perkins BA, Aiello LP, Krolewski AS. Diabetes complications and the renin-angiotensin system. N Engl J Med. 2009 Jul 2; 361(1):83-5.
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  34. Perkins BA, Krolewski AS. Early nephropathy in type 1 diabetes: the importance of early renal function decline. Curr Opin Nephrol Hypertens. 2009 May; 18(3):233-40.
    View in: PubMed
  35. Pezzolesi MG, Poznik GD, Mychaleckyj JC, Paterson AD, Barati MT, Klein JB, Ng DP, Placha G, Canani LH, Bochenski J, Waggott D, Merchant ML, Krolewski B, Mirea L, Wanic K, Katavetin P, Kure M, Wolkow P, Dunn JS, Smiles A, Walker WH, Boright AP, Bull SB, Doria A, Rogus JJ, Rich SS, Warram JH, Krolewski AS. Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. Diabetes. 2009 Jun; 58(6):1403-10.
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  36. Ficociello LH, Perkins BA, Roshan B, Weinberg JM, Aschengrau A, Warram JH, Krolewski AS. Renal hyperfiltration and the development of microalbuminuria in type 1 diabetes. Diabetes Care. 2009 May; 32(5):889-93.
    View in: PubMed
  37. Tsaih S, Pezzolesi MG, Yuan R, Warram JH, Krolewski AS, Korstanje R. Genetic analysis of albuminuria in the aging mouse and concordance with loci for diabetic nephropathy found in a genome-wide association scan. J Am Soc Neph. 2009; Submitted.
  38. Ficociello LH, Rosolowsky ET, Niewczas M, Maselli NJ, Roshan B, Weinberg JM, Aschengrau A, Stanton RC, Doria D, Warram JH, Krolewski AS. Serum Uric Acid and Early Renal Function Decline in Patients with Type 1 Diabetes and Microalbuminuria. Kidney Int. 2009; (accepted for publication).
  39. Merchant ML, Perkins BA, Boratyn GM, Ficociello LH, Wilkey DW, Barati MT, Bertram CC, Page GP, Rovin BH, Warram JH, Krolewski AS (senior author), Klein JB. Urinary petidome analysis and early renal function decline in type 1 diabetics with microalbuminuria. J Am Soc Nephrol. 2009; (accepted for publication).
  40. Niewczas MA, Ficociello LH, Johnson AC, Walker W, Rosolowsky ET, Roshan B, Warram JH, Krolewski AS. Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes. Clin J Am Soc Nephrol. 2009 Jan; 4(1):62-70.
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  41. Rosolowsky ET, Niewczas MA, Ficociello LH, Perkins BA, Warram JH, Krolewski AS. Between hyperfiltration and impairment: demystifying early renal functional changes in diabetic nephropathy. Diabetes Res Clin Pract. 2008 Nov 13; 82 Suppl 1:S46-53.
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  42. Wanic K, Placha G, Dunn J, Smiles A, Warram JH, Krolewski AS. Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies. Diabetes. 2008 Sep; 57(9):2547-51.
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  43. Rogus JJ, Poznik GD, Pezzolesi MG, Smiles AM, Dunn J, Walker W, Wanic K, Moczulski D, Canani L, Araki S, Makita Y, Warram JH, Krolewski AS. High-density single nucleotide polymorphism genome-wide linkage scan for susceptibility genes for diabetic nephropathy in type 1 diabetes: discordant sibpair approach. Diabetes. 2008 Sep; 57(9):2519-26.
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  44. Ng DP, Nurbaya S, Ye SH, Krolewski AS. An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients. Kidney Int. 2008 Aug; 74(4):521-7.
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  45. Rosolowsky ET, Ficociello LH, Maselli NJ, Niewczas MA, Binns AL, Roshan B, Warram JH, Krolewski AS. High-normal serum uric acid is associated with impaired glomerular filtration rate in nonproteinuric patients with type 1 diabetes. Clin J Am Soc Nephrol. 2008 May; 3(3):706-13.
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  46. Ng DP, Nurbaya S, Choo S, Koh D, Chia KS, Krolewski AS. Genetic variation at the SLC12A3 locus is unlikely to explain risk for advanced diabetic nephropathy in Caucasians with type 2 diabetes. Nephrol Dial Transplant. 2008 Jul; 23(7):2260-4.
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  47. Wolkow PP, Niewczas MA, Perkins B, Ficociello LH, Lipinski B, Warram JH, Krolewski AS. Association of urinary inflammatory markers and renal decline in microalbuminuric type 1 diabetics. J Am Soc Nephrol. 2008 Apr; 19(4):789-97.
    View in: PubMed
  48. Wanic K, Malecki MT, Klupa T, Warram JH, Sieradzki J, Krolewski AS. Lack of association between polymorphisms in the gene encoding protein tyrosine phosphatase 1B (PTPN1) and risk of Type 2 diabetes. Diabet Med. 2007 Jun; 24(6):650-5.
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  49. Ficociello LH, Perkins BA, Silva KH, Finkelstein DM, Ignatowska-Switalska H, Gaciong Z, Cupples LA, Aschengrau A, Warram JH, Krolewski AS. Determinants of progression from microalbuminuria to proteinuria in patients who have type 1 diabetes and are treated with angiotensin-converting enzyme inhibitors. Clin J Am Soc Nephrol. 2007 May; 2(3):461-9.
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  50. Keenan HA, Poznik GD, Varo N, Schneider J, Almasy L, Warram JH, Duggirala R, Schoenbeck U, Krolewski AS, Doria A. Identification of a locus modulating serum C-reactive protein levels on chromosome 5p15. Atherosclerosis. 2008 Feb; 196(2):863-70.
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  51. Perkins BA, Ficociello LH, Ostrander BE, Silva KH, Weinberg J, Warram JH, Krolewski AS. Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes. J Am Soc Nephrol. 2007 Apr; 18(4):1353-61.
    View in: PubMed
  52. Wanic K, Malecki MT, Klupa T, Warram JH, Sieradzki J, Krolewski AS. Lack of association between polymorphisms in the gene encoding protein phosphatase 1B (PTPN1) and risk of type 2 diabetes. Diabetic Med. 2007; 24(6):650-5.
  53. Placha G, Poznik GD, Dunn J, Smiles A, Krolewski B, Glew T, Puppala S, Schneider J, Rogus JJ, Rich SS, Duggirala R, Warram JH, Krolewski AS. A genome-wide linkage scan for genes controlling variation in renal function estimated by serum cystatin C levels in extended families with type 2 diabetes. Diabetes. 2006 Dec; 55(12):3358-65.
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  54. Ng DP, Placha G, Choo S, Chia KS, Warram JH, Krolewski AS. A disease haplotype for advanced nephropathy in type 2 diabetes at the ACE locus. Diabetes. 2006 Sep; 55(9):2660-3.
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  55. Dunn JS, Mlynarski WM, Pezzolesi MG, Borowiec M, Powers C, Krolewski AS, Doria A. Examination of PPP1R3B as a candidate gene for the type 2 diabetes and MODY loci on chromosome 8p23. Ann Hum Genet. 2006 Sep; 70(Pt 5):587-93.
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  56. Bochenski J, Placha G, Wanic K, Malecki M, Sieradzki J, Warram JH, Krolewski AS. New polymorphism of ENPP1 (PC-1) is associated with increased risk of type 2 diabetes among obese individuals. Diabetes. 2006 Sep; 55(9):2626-30.
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  57. Mueller PW, Rogus JJ, Cleary PA, Zhao Y, Smiles AM, Steffes MW, Bucksa J, Gibson TB, Cordovado SK, Krolewski AS, Nierras CR, Warram JH. Genetics of Kidneys in Diabetes (GoKinD) study: a genetics collection available for identifying genetic susceptibility factors for diabetic nephropathy in type 1 diabetes. J Am Soc Nephrol. 2006 Jul; 17(7):1782-90.
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  58. Malecki MT, Lebrun P, Pezzolesi M, Warram JH, Krolewski AS, Jhala US. A newly identified mutation in an IPF1 binding site of the insulin gene promoter may predispose to type 2 diabetes mellitus. Diabetologia. 2006 Aug; 49(8):1985-7.
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  59. Wanic K, Malecki MT, Wolkow PP, Klupa T, Skupien J, Bobrek J, Kozek E, Krolewski AS, Sieradzki J. Polymorphisms in the gene encoding hepatocyte nuclear factor-4alpha and susceptibility to type 2 diabetes in a Polish population. Diabetes Metab. 2006 Feb; 32(1):86-8.
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  60. Placha G, Krolewski AS. Genetic determinants of diabetic nephropathy in type 2 diabetes. The diabetic kidney. Cortes P and Mogensen CE eds). 2006; 329-50.
  61. Mueller PM, Rogus JJ, Cleary PA, Zhao Y, Smiles AM, Steffes MW, Bucksa J, Gibson TB, Cordovado SK, Krolewski AS, Nierras CR, Warram JH. The Genetics of Kidneys in Diabetes (GoKinD) Study: A genetics collection available for identifying the genetic susceptibility factors for diabetic nephropathy in type 1 diabetes mellitus. J Am Soc Neph. 2006; 17(7):1782-90.
  62. Krolewski AS, Poznik GD, Placha G, Canani L, Dunn J, Walker W, Smiles A, Krolewski B, Fogarty DG, Moczulski D, Araki S, Makita Y, Ng DP, Rogus J, Duggirala R, Rich SS, Warram JH. A genome-wide linkage scan for genes controlling variation in urinary albumin excretion in type II diabetes. Kidney Int. 2006 Jan; 69(1):129-36.
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  63. Poznik GD, Adamska K, Xu X, Krolewski AS, Rogus JJ. A novel framework for sib pair linkage analysis. Am J Hum Genet. 2006 Feb; 78(2):222-30.
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  64. Perkins BA, Krolewski AS. Early nephropathy in type 1 diabetes: a new perspective on who will and who will not progress. Curr Diab Rep. 2005 Dec; 5(6):455-63.
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  65. Mlynarski WM, Placha GP, Wolkow PP, Bochenski JP, Warram JH, Krolewski AS. Risk of diabetic nephropathy in type 1 diabetes is associated with functional polymorphisms in RANTES receptor gene (CCR5): a sex-specific effect. Diabetes. 2005 Nov; 54(11):3331-5.
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  66. Canani LH, Capp C, Ng DP, Choo SG, Maia AL, Nabinger GB, Santos K, Crispim D, Roisemberg I, Krolewski AS, Gross JL. The fatty acid-binding protein-2 A54T polymorphism is associated with renal disease in patients with type 2 diabetes. Diabetes. 2005 Nov; 54(11):3326-30.
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  67. Perkins BA, Nelson RG, Krolewski AS. Cystatin C and the risk of death. N Engl J Med. 2005 Aug 25; 353(8):842-4; author reply 842-4.
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  68. Ng DP, Krolewski AS. Molecular genetic approaches for studying the etiology of diabetic nephropathy. Curr Mol Med. 2005 Aug; 5(5):509-25.
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  69. Jones CA, Krolewski AS, Rogus J, Xue JL, Collins A, Warram JH. Epidemic of end-stage renal disease in people with diabetes in the United States population: do we know the cause? Kidney Int. 2005 May; 67(5):1684-91.
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  70. Placha G, Canani LH, Warram JH, Krolewski AS. Evidence for different susceptibility genes for proteinuria and ESRD in type 2 diabetes. Adv Chronic Kidney Dis. 2005 Apr; 12(2):155-69.
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  71. Perkins BA, Nelson RG, Ostrander BE, Blouch KL, Krolewski AS, Myers BD, Warram JH. Detection of renal function decline in patients with diabetes and normal or elevated GFR by serial measurements of serum cystatin C concentration: results of a 4-year follow-up study. J Am Soc Nephrol. 2005 May; 16(5):1404-12.
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  72. Warram JH, Krolewski AS. Epidemiology of diabetes mellitus. Joslin's Diabetes Mellitus. Kahn CR, Weir G, King GL, Jacobson AM, Moses AC, Smith RJ (eds.). 2005; 341-354.
  73. Krolewski AS, Warram JH. Epidemiology of late complications of diabetes. Basis for the development and evaluation of preventive programs. Joslin's Diabetes Mellitus. Kahn CR, Weir G, King GL, Jacobson AM, Moses AC, Smith RJ (eds.). 2005; 795-808.
  74. Kim SH, Ma X, Weremowicz S, Ercolino T, Powers C, Mlynarski W, Bashan KA, Warram JH, Mychaleckyj J, Rich SS, Krolewski AS, Doria A. Identification of a locus for maturity-onset diabetes of the young on chromosome 8p23. Diabetes. 2004 May; 53(5):1375-84.
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  75. Ng DP, Walker WH, Chia KS, Choo S, Warram JH, Krolewski AS. Scrutiny of the glutamine-fructose-6-phosphate transaminase 1 (GFPT1) locus reveals conserved haplotype block structure not associated with diabetic nephropathy. Diabetes. 2004 Mar; 53(3):865-9.
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  76. Pezzolesi MG, Nam M, Nagase T, Klupa T, Dunn JS, Mlynarski WM, Rich SS, Warram JH, Krolewski AS. Examination of candidate chromosomal regions for type 2 diabetes reveals a susceptibility locus on human chromosome 8p23.1. Diabetes. 2004 Feb; 53(2):486-91.
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  77. Ng DP, Warram JH, Krolewski AS. To: Rippin JD, Patel A, Belyaev ND, Gill GV, Barnett AH, Bain SC (2003) Nitric oxide synthase gene polymorphisms and diabetic nephropathy. Diabetologia 46:426-428. Diabetologia. 2003 Dec; 46(12):1706.
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  78. Araki S, Ng DP, Krolewski B, Wyrwicz L, Rogus JJ, Canani L, Makita Y, Haneda M, Warram JH, Krolewski AS. Identification of a common risk haplotype for diabetic nephropathy at the protein kinase C-beta1 (PRKCB1) gene locus. J Am Soc Nephrol. 2003 Aug; 14(8):2015-24.
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  79. Kim SH, Ma X, Klupa T, Powers C, Pezzolesi M, Warram JH, Rich SS, Krolewski AS, Doria A. Genetic modifiers of the age at diagnosis of diabetes (MODY3) in carriers of hepatocyte nuclear factor-1alpha mutations map to chromosomes 5p15, 9q22, and 14q24. Diabetes. 2003 Aug; 52(8):2182-6.
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  80. Perkins BA, Ficociello LH, Silva KH, Finkelstein DM, Warram JH, Krolewski AS. Regression of microalbuminuria in type 1 diabetes. N Engl J Med. 2003 Jun 5; 348(23):2285-93.
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  81. Makita Y, Moczulski DK, Bochenski J, Smiles AM, Warram JH, Krolewski AS. Methylenetetrahydrofolate reductase gene polymorphism and susceptibility to diabetic nephropathy in type 1 diabetes. Am J Kidney Dis. 2003 Jun; 41(6):1189-94.
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  82. Ng DP, Warram JH, Krolewski AS. TGF-beta 1 as a genetic susceptibility locus for advanced diabetic nephropathy in type 1 diabetes mellitus: an investigation of multiple known DNA sequence variants. Am J Kidney Dis. 2003 Jan; 41(1):22-8.
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  83. Klupa T, Warram JH, Antonellis A, Pezzolesi M, Nam M, Malecki MT, Doria A, Rich SS, Krolewski AS. Determinants of the development of diabetes (maturity-onset diabetes of the young-3) in carriers of HNF-1alpha mutations: evidence for parent-of-origin effect. Diabetes Care. 2002 Dec; 25(12):2292-301.
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  84. Szabó C, Zanchi A, Komjáti K, Pacher P, Krolewski AS, Quist WC, LoGerfo FW, Horton ES, Veves A. Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity. Circulation. 2002 Nov 19; 106(21):2680-6.
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  85. Ng DP, Canani L, Araki S, Smiles A, Moczulski D, Warram JH, Krolewski AS. Minor effect of GLUT1 polymorphisms on susceptibility to diabetic nephropathy in type 1 diabetes. Diabetes. 2002 Jul; 51(7):2264-9.
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  86. Rogus JJ, Warram JH, Krolewski AS. Genetic studies of late diabetic complications: the overlooked importance of diabetes duration before complication onset. Diabetes. 2002 Jun; 51(6):1655-62.
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  87. Canani LH, Ng DP, Smiles A, Rogus JJ, Warram JH, Krolewski AS. Polymorphism in ecto-nucleotide pyrophosphatase/phosphodiesterase 1 gene (ENPP1/PC-1) and early development of advanced diabetic nephropathy in type 1 diabetes. Diabetes. 2002 Apr; 51(4):1188-93.
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  88. Antonellis A, Rogus JJ, Canani LH, Makita Y, Pezzolesi MG, Nam M, Ng D, Moczulski D, Warram JH, Krolewski AS. A method for developing high-density SNP maps and its application at the type 1 angiotensin II receptor (AGTR1) locus. Genomics. 2002 Mar; 79(3):326-32.
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  89. Weijnen CF, Rich SS, Meigs JB, Krolewski AS, Warram JH. Risk of diabetes in siblings of index cases with Type 2 diabetes: implications for genetic studies. Diabet Med. 2002 Jan; 19(1):41-50.
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  90. Scott LJ, Warram JH, Hanna LS, Laffel LM, Ryan L, Krolewski AS. A nonlinear effect of hyperglycemia and current cigarette smoking are major determinants of the onset of microalbuminuria in type 1 diabetes. Diabetes. 2001 Dec; 50(12):2842-9.
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  91. Moczulski DK, Rogus JJ, Krolewski AS. Comment to: F. M. Nakhoul et al. (2001) Haptoglobin phenotype and diabetes. Diabetologia 44: 602-604. Diabetologia. 2001 Dec; 44(12):2237-8.
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  92. Canani LH, Araki S, Warram JH, Krolewski AS. Comment--to: Pinizzotto M, Castillo E, Fiaux M, Temler E, Gaillard RC, Ruiz J (2001) Paraoxonase 2 polymorphisms are associated with diabetic nephropathy in Type II diabetes. Diabetologia 44: 104-107. Diabetologia. 2001 Aug; 44(8):1062-4.
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  93. Kim SH, Warram JH, Krolewski AS, Doria A. Mutation screening of the neurogenin-3 gene in autosomal dominant diabetes. J Clin Endocrinol Metab. 2001 May; 86(5):2320-2.
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  94. Krolewski AS, Ng DP, Canani LH, Warram JH. Genetics of diabetic nephropathy: how far are we from finding susceptibility genes? Adv Nephrol Necker Hosp. 2001; 31:295-315.
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  95. Bektas A, Hughes JN, Warram JH, Krolewski AS, Doria A. Type 2 diabetes locus on 12q15. Further mapping and mutation screening of two candidate genes. Diabetes. 2001 Jan; 50(1):204-8.
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  96. Araki S, Moczulski DK, Hanna L, Scott LJ, Warram JH, Krolewski AS. APOE polymorphisms and the development of diabetic nephropathy in type 1 diabetes: results of case-control and family-based studies. Diabetes. 2000 Dec; 49(12):2190-5.
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  97. Araki S, Makita Y, Canani L, Ng D, Warram JH, Krolewski AS. Polymorphisms of human paraoxonase 1 gene (PON1) and susceptibility to diabetic nephropathy in type I diabetes mellitus. Diabetologia. 2000 Dec; 43(12):1540-3.
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  98. Klupa T, Malecki MT, Pezzolesi M, Ji L, Curtis S, Langefeld CD, Rich SS, Warram JH, Krolewski AS. Further evidence for a susceptibility locus for type 2 diabetes on chromosome 20q13.1-q13.2. Diabetes. 2000 Dec; 49(12):2212-6.
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  99. Fogarty DG, Hanna LS, Wantman M, Warram JH, Krolewski AS, Rich SS. Segregation analysis of urinary albumin excretion in families with type 2 diabetes. Diabetes. 2000 Jun; 49(6):1057-63.
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  100. Rabinowitz D, Zanchi A, Schaumberg D, Krolewski A. Testing mode of inheritance of a candidate mutation at a quantitative trait locus. Hum Hered. 2000 May-Jun; 50(3):184-8.
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  101. Moczulski DK, Scott L, Antonellis A, Rogus JJ, Rich SS, Warram JH, Krolewski AS. Aldose reductase gene polymorphisms and susceptibility to diabetic nephropathy in Type 1 diabetes mellitus. Diabet Med. 2000 Feb; 17(2):111-8.
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  102. Zanchi A, Moczulski DK, Hanna LS, Wantman M, Warram JH, Krolewski AS. Risk of advanced diabetic nephropathy in type 1 diabetes is associated with endothelial nitric oxide synthase gene polymorphism. Kidney Int. 2000 Feb; 57(2):405-13.
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  103. Fogarty DG, Rich SS, Hanna L, Warram JH, Krolewski AS. Urinary albumin excretion in families with type 2 diabetes is heritable and genetically correlated to blood pressure. Kidney Int. 2000 Jan; 57(1):250-7.
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  104. Warram JH, Scott LJ, Hanna LS, Wantman M, Cohen SE, Laffel LM, Ryan L, Krolewski AS. Progression of microalbuminuria to proteinuria in type 1 diabetes: nonlinear relationship with hyperglycemia. Diabetes. 2000 Jan; 49(1):94-100.
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  105. Malecki M, Krolewski AS. [Molecular background and clinical characteristics of autosomal dominant type 2 diabetes mellitus]. Przegl Lek. 2000; 57 Suppl 3:13-8.
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  106. Price JA, Brewer CS, Howard TD, Fossey SC, Sale MM, Ji L, Krolewski AS, Bowden DW. A physical map of the 20q12-q13.1 region associated with type 2 diabetes. Genomics. 1999 Dec 1; 62(2):208-15.
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  107. Bektas A, Suprenant ME, Wogan LT, Plengvidhya N, Rich SS, Warram JH, Krolewski AS, Doria A. Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q. Diabetes. 1999 Nov; 48(11):2246-51.
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  108. Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, Orban T, Saad M, Warram JH, Montminy M, Krolewski AS. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat Genet. 1999 Nov; 23(3):323-8.
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  109. Klupa T, Malecki M, Hanna L, Sieradzka J, Frey J, Warram JH, Sieradzki J, Krolewski AS. Amino acid variants of the vitamin D-binding protein and risk of diabetes in white Americans of European origin. Eur J Endocrinol. 1999 Nov; 141(5):490-3.
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  110. Plengvidhya N, Antonellis A, Wogan LT, Poleev A, Borgschulze M, Warram JH, Ryffel GU, Krolewski AS, Doria A. Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. Diabetes. 1999 Oct; 48(10):2099-102.
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  111. Cohen RA, Hennekens CH, Christen WG, Krolewski A, Nathan DM, Peterson MJ, LaMotte F, Manson JE. Determinants of retinopathy progression in type 1 diabetes mellitus. Am J Med. 1999 Jul; 107(1):45-51.
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  112. Krolewski AS. Genetics of diabetic nephropathy: evidence for major and minor gene effects. Kidney Int. 1999 Apr; 55(4):1582-96.
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  113. Malecki MT, Yang Y, Antonellis A, Curtis S, Warram JH, Krolewski AS. Identification of new mutations in the hepatocyte nuclear factor 4alpha gene among families with early onset Type 2 diabetes mellitus. Diabet Med. 1999 Mar; 16(3):193-200.
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  114. Bektas A, Warram JH, White MF, Krolewski AS, Doria A. Exclusion of insulin receptor substrate 2 (IRS-2) as a major locus for early-onset autosomal dominant type 2 diabetes. Diabetes. 1999 Mar; 48(3):640-2.
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  115. Doria A, Yang Y, Malecki M, Scotti S, Dreyfus J, O'Keeffe C, Orban T, Warram JH, Krolewski AS. Phenotypic characteristics of early-onset autosomal-dominant type 2 diabetes unlinked to known maturity-onset diabetes of the young (MODY) genes. Diabetes Care. 1999 Feb; 22(2):253-61.
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  116. Fogarty DG, Zychma MJ, Scott LJ, Warram JH, Krolewski AS. The C825T polymorphism in the human G-protein beta3 subunit gene is not associated with diabetic nephropathy in Type I diabetes mellitus. Diabetologia. 1998 Nov; 41(11):1304-8.
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  117. Freire MB, van Dijk DJ, Erman A, Boner G, Warram JH, Krolewski AS. DNA polymorphisms in the ACE gene, serum ACE activity and the risk of nephropathy in insulin-dependent diabetes mellitus. Nephrol Dial Transplant. 1998 Oct; 13(10):2553-8.
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  118. Moczulski DK, Rogus JJ, Antonellis A, Warram JH, Krolewski AS. Major susceptibility locus for nephropathy in type 1 diabetes on chromosome 3q: results of novel discordant sib-pair analysis. Diabetes. 1998 Jul; 47(7):1164-9.
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  119. Malecki MT, Antonellis A, Casey P, Ji L, Wantman M, Warram JH, Krolewski AS. Exclusion of the hepatocyte nuclear factor 4alpha as a candidate gene for late-onset NIDDM linked with chromosome 20q. Diabetes. 1998 Jun; 47(6):970-2.
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  120. Krolewski AS, Fogarty DG, Warram JH. Hypertension and nephropathy in diabetes mellitus: what is inherited and what is acquired? Diabetes Res Clin Pract. 1998 Apr; 39 Suppl:S1-14.
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  121. Freire MB, Ji L, Onuma T, Orban T, Warram JH, Krolewski AS. Gender-specific association of M235T polymorphism in angiotensinogen gene and diabetic nephropathy in NIDDM. Hypertension. 1998 Apr; 31(4):896-9.
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  122. Jeanclos E, Krolewski A, Skurnick J, Kimura M, Aviv H, Warram JH, Aviv A. Shortened telomere length in white blood cells of patients with IDDM. Diabetes. 1998 Mar; 47(3):482-6.
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  123. Rogus JJ, Moczulski D, Freire MB, Yang Y, Warram JH, Krolewski AS. Diabetic nephropathy is associated with AGT polymorphism T235: results of a family-based study. Hypertension. 1998 Feb; 31(2):627-31.
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  124. Rogus JJ, Krolewski AS. New developments in the search for nephropathy susceptibility genes in IDDM. The Diabetes Annual, 11th Edition. Marshall SM, Home PD, Rizza R (eds.). 1998; 49-61.
  125. Warram JH, Krolewski AS. Use of the albumin/creatinine ratio in patient care and clinical studies. The Kidney and Hypertension in Diabetes Mellitus. Mogensen CE (ed.). 1998; 85-96.
  126. Doria A, Onuma T, Warram JH, Krolewski AS. Synergistic effect of angiotensin II type 1 receptor genotype and poor glycaemic control on risk of nephropathy in IDDM. Diabetologia. 1997 Nov; 40(11):1293-9.
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  127. Lipinski B, Krolewski AS. Macromolecular protein complex in human plasma may explain altered fibrin gel structure in IDDM patients. Diabetologia. 1997 Jul; 40(7):869.
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  128. Sigal RJ, El-Hashimy M, Martin BC, Soeldner JS, Krolewski AS, Warram JH. Acute postchallenge hyperinsulinemia predicts weight gain: a prospective study. Diabetes. 1997 Jun; 46(6):1025-9.
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  129. Ji L, Malecki M, Warram JH, Yang Y, Rich SS, Krolewski AS. New susceptibility locus for NIDDM is localized to human chromosome 20q. Diabetes. 1997 May; 46(5):876-81.
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  130. Fogarty DG, Krolewski AS. Genetic susceptibility and the role of hypertension in diabetic nephropathy. Curr Opin Nephrol Hypertens. 1997 Mar; 6(2):184-91.
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  131. Warram JH, Kopczynski J, Janka HU, Krolewski AS. Epidemiology of non-insulin-dependent diabetes mellitus and its macrovascular complications. A basis for the development of cost-effective programs. Endocrinol Metab Clin North Am. 1997 Mar; 26(1):165-88.
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  132. Lipinski B, Krolewski AS. Ticlopidine may reduce functional fibrinogen levels by inhibition of MPC incorporation into fibrin. Thromb Haemost. 1997 Mar; 77(3):603-4.
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  133. Warram JH, Kopczynski J, Janka HU, Krolewski AS. Epidemiology of non-insulin-dependent diabetes mellitus and its macrovascular complications: a basis for the development of cost-effective programs. Endocrin Metab Clin N Am. 1997; 26:165-188.
  134. Fogarty DG, Krolewski AS. Genetic susceptibility and the role of hypertension in diabetes nephropathy. Curr Opin Neph Hypert. 1997; 6:184-191.
  135. Krolewski AS, Warram JH. Clinical features and epidemiology of diabetic nephropathy. Textbook of Diabetes, 2nd Edition. Pickup JC, Williams G (eds.). 1997; 53.1-53.13.
  136. Rogus JJ, Krolewski AS. Using discordant sib pairs to map loci for qualitative traits with high sibling recurrence risk. Am J Hum Genet. 1996 Dec; 59(6):1376-81.
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  137. Warram JH, Sigal RJ, Martin BC, Krolewski AS, Soeldner JS. Natural history of impaired glucose tolerance: follow-up at Joslin Clinic. Diabet Med. 1996 Sep; 13(9 Suppl 6):S40-5.
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  138. Quinn M, Angelico MC, Warram JH, Krolewski AS. Familial factors determine the development of diabetic nephropathy in patients with IDDM. Diabetologia. 1996 Aug; 39(8):940-5.
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  139. Onuma T, Laffel LM, Angelico MC, Krolewski AS. Apolipoprotein E genotypes and risk of diabetic nephropathy. J Am Soc Nephrol. 1996 Jul; 7(7):1075-8.
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  140. Krolewski AS, Warram JH, Freire MB. Epidemiology of late diabetic complications. A basis for the development and evaluation of preventive programs. Endocrinol Metab Clin North Am. 1996 Jun; 25(2):217-242.
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  141. Warram JH, Gearin G, Laffel L, Krolewski AS. Effect of duration of type I diabetes on the prevalence of stages of diabetic nephropathy defined by urinary albumin/creatinine ratio. J Am Soc Nephrol. 1996 Jun; 7(6):930-7.
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  142. Doria A, Lee J, Warram JH, Krolewski AS. Diabetes susceptibility at IDDM2 cannot be positively mapped to the VNTR locus of the insulin gene. Diabetologia. 1996 May; 39(5):594-9.
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  143. Doria A, Onuma T, Gearin G, Freire MB, Warram JH, Krolewski AS. Angiotensinogen polymorphism M235T, hypertension, and nephropathy in insulin-dependent diabetes. Hypertension. 1996 May; 27(5):1134-9.
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  144. Sigal RJ, Doria A, Warram JH, Krolewski AS. Codon 972 polymorphism in the insulin receptor substrate-1 gene, obesity, and risk of noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1996 Apr; 81(4):1657-9.
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  145. Krolewski AS, Warram JH, Friere MBS. Epidemiology of late diabetic complications: a basis for the development and evaluation of preventive programs. Endocrin Metab Clin N Am. 1996; 25:217-42.
  146. Sigal RJ, Freire MB, Krolewski AS. Could differences in body mass index and/or insulin sensitivity explain the association between parental diabetic nephropathy and risk of diabetes in offspring? Diabetologia. 1995 Dec; 38(12):1486-7.
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  147. Doria A, Warram JH, Krolewski AS. Genetic susceptibility to nephropathy in insulin-dependent diabetes: from epidemiology to molecular genetics. Diabetes Metab Rev. 1995 Dec; 11(4):287-314.
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  148. Krolewski AS, Warram JH. Genetic susceptibility to diabetic kidney disease: an update. J Diabetes Complications. 1995 Oct-Dec; 9(4):277-81.
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  149. Sweeney FP, Siczkowski M, Davies JE, Quinn PA, McDonald J, Krolewski B, Krolewski AS, Ng LL. Phosphorylation and activity of Na+/H+ exchanger isoform 1 of immortalized lymphoblasts in diabetic nephropathy. Diabetes. 1995 Oct; 44(10):1180-5.
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  150. Fong DS, Warram JH, Aiello LM, Rand LI, Krolewski AS. Cardiovascular autonomic neuropathy and proliferative diabetic retinopathy. Am J Ophthalmol. 1995 Sep; 120(3):317-21.
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  151. Lipinski B, Federman SM, Krolewski AS. Plasma macromolecular protein complex: interaction with fibrin and fibrinolysis. Thromb Res. 1995 Jun 1; 78(5):461-5.
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  152. Magré J, Goldfine AB, Warram JH, Krolewski AS, Kahn CR. Analysis of the insulin receptor gene in noninsulin-dependent diabetes mellitus by denaturing gradient gel blots: a clinical research center study. J Clin Endocrinol Metab. 1995 Jun; 80(6):1882-7.
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  153. Krolewski AS, Laffel LM, Krolewski M, Quinn M, Warram JH. Glycosylated hemoglobin and the risk of microalbuminuria in patients with insulin-dependent diabetes mellitus. N Engl J Med. 1995 May 11; 332(19):1251-5.
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  154. Warram JH, Manson JE, Krolewski AS. Glycosylated hemoglobin and the risk of retinopathy in insulin-dependent diabetes mellitus. N Engl J Med. 1995 May 11; 332(19):1305-6.
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  155. Ng LL, Sweeney FP, Siczkowski M, Davies JE, Quinn PA, Krolewski B, Krolewski AS. Na(+)-H+ antiporter phenotype, abundance, and phosphorylation of immortalized lymphoblasts from humans with hypertension. Hypertension. 1995 May; 25(5):971-7.
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  156. Davies JE, Siczkowski M, Sweeney FP, Quinn PA, Krolewski B, Krolewski AS, Ng LL. Glucose-induced changes in turnover of Na+/H+ exchanger of immortalized lymphoblasts from type I diabetic patients with nephropathy. Diabetes. 1995 Apr; 44(4):382-8.
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  157. el-Hashimy M, Angelico MC, Martin BC, Krolewski AS, Warram JH. Factors modifying the risk of IDDM in offspring of an IDDM parent. Diabetes. 1995 Mar; 44(3):295-9.
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  158. Doria A, Caldwell JS, Ji L, Reynet C, Rich SS, Weremowicz S, Morton CC, Warram JH, Kahn CR, Krolewski AS. Trinucleotide repeats at the rad locus. Allele distributions in NIDDM and mapping to a 3-cM region on chromosome 16q. Diabetes. 1995 Feb; 44(2):243-7.
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  159. Krolewski AS, Warram JH. Genetic susceptibility to diabetic kidney disease: an update. J Diabet Complications. 1995; 9:277-281.
  160. Krolewski AS, Warram JH. Natural history of diabetes mellitus. Principles and Practice of Endrocrinology and Metabolism. Becker KL (ed.). 1995; 1216-1220.
  161. Krolewski AS, Warram JH. Natural history of diabetic nephropathy: how much can it be changed?. Diabetes Rev. 1995; 3:446-459.
  162. Lipinski B, Federman SM, Krolewski AS. Comments on plasma fibrinogen levels measured by functional methods. Thromb Haemost. 1994 Dec; 72(6):985.
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  163. Doria A, Warram JH, Rich SS, Krolewski AS. Angiotensin I-converting enzyme (ACE): estimation of DNA haplotypes in unrelated individuals using denaturing gradient gel blots. Hum Genet. 1994 Aug; 94(2):117-23.
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  164. Doria A, Ji L, Warram JH, Krolewski AS. DdeI polymorphism in the AGTR1 gene. Hum Mol Genet. 1994 Aug; 3(8):1444.
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  165. Ng LL, Davies JE, Siczkowski M, Sweeney FP, Quinn PA, Krolewski B, Krolewski AS. Abnormal Na+/H+ antiporter phenotype and turnover of immortalized lymphoblasts from type 1 diabetic patients with nephropathy. J Clin Invest. 1994 Jun; 93(6):2750-7.
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  166. Doria A, Warram JH, Krolewski AS. Genetic predisposition to diabetic nephropathy. Evidence for a role of the angiotensin I--converting enzyme gene. Diabetes. 1994 May; 43(5):690-5.
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  167. Krolewski AS, Warram JH, Christlieb AR. Hypercholesterolemia--a determinant of renal function loss and deaths in IDDM patients with nephropathy. Kidney Int Suppl. 1994 Feb; 45:S125-31.
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  168. Doria A, Warram JH, Krolewski AS. Molecular characterization of a DDEI melting polymorphism at the angiotensin I-converting enzyme (ACE) locus. Hum Mutat. 1994; 4(2):155-7.
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  169. Warram JH, Rich SS, Krolewski AS. Epidemiology and genetics of diabetes mellitus. Joslin's Diabetes Mellitus, 13th Edition. Kahn CR and Weir G (eds.). 1994; 201-15.
  170. Christlieb AR, Krolewski AS, Warram JH. Hypertension. Joslin's Diabetes Mellitus, 13th Edition. Kahn CR and Weir G (eds.). 1994; 817-835.
  171. Krolewski AS, Warram JH. Epidemiology of late diabetic complications. Joslin's Diabetes Mellitus, 13th Edition. Kahn CR and Weir G (eds.). 1994; 605-619.
  172. Shimakawa T, Warram JH, Herrera-Acena MG, Krolewski AS. Usual dietary intake and hemoglobin A1 level in patients with insulin-dependent diabetes. J Am Diet Assoc. 1993 Dec; 93(12):1409-12, 1415; quiz 1413-4.
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  173. Doria A, Warram JH, Krolewski AS. Four RSAI restriction fragment melting polymorphisms in the region of the insulin receptor gene encoding for the alpha subunit. Clin Genet. 1993 Nov; 44(5):279-80.
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  174. Parker S, Angelico MC, Laffel L, Krolewski AS. Application of denaturing gradient gel electrophoresis to detect DNA sequence differences encoding apolipoprotein E isoforms. Genomics. 1993 Apr; 16(1):245-7.
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  175. Valsania P, Warram JH, Rand LI, Krolewski AS. Different determinants of neovascularization on the optic disc and on the retina in patients with severe nonproliferative diabetic retinopathy. Arch Ophthalmol. 1993 Feb; 111(2):202-6.
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  176. Krolewski AS, Warram JH. Epidemiology and genetics of hypertension in diabetes mellitus. Diabetes and Atherosclerosis - Molecular Basis and Clinical Aspects. Draznin B and Eckel R (eds.). 1993; 339-356.
  177. Doria A, Warram JH, Krolewski AS. Molecular methods for the study of the genetic determinants of nephropathy in type 1 (insulin-dependent) diabetes. Acta Diabetol. 1993; 29:136-41.
  178. Martin BC, Warram JH, Krolewski AS, Bergman RN, Soeldner JS, Kahn CR. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet. 1992 Oct 17; 340(8825):925-9.
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  179. Krolewski AS. Hypertension associated with diabetes mellitus--past and future. J Am Soc Nephrol. 1992 Oct; 3(4 Suppl):S1.
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  180. Krolewski AS, Doria A, Magre J, Warram JH, Housman D. Molecular genetic approaches to the identification of genes involved in the development of nephropathy in insulin-dependent diabetes mellitus. J Am Soc Nephrol. 1992 Oct; 3(4 Suppl):S9-17.
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  181. Siegel JE, Krolewski AS, Warram JH, Weinstein MC. Cost-effectiveness of screening and early treatment of nephropathy in patients with insulin-dependent diabetes mellitus. J Am Soc Nephrol. 1992 Oct; 3(4 Suppl):S111-9.
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  182. Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, Hennekens CH. A prospective study of exercise and incidence of diabetes among US male physicians. JAMA. 1992 Jul 1; 268(1):63-7.
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  183. Martin BC, Warram JH, Rosner B, Rich SS, Soeldner JS, Krolewski AS. Familial clustering of insulin sensitivity. Diabetes. 1992 Jul; 41(7):850-4.
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  184. Barzilay J, Warram JH, Bak M, Laffel LM, Canessa M, Krolewski AS. Predisposition to hypertension: risk factor for nephropathy and hypertension in IDDM. Kidney Int. 1992 Apr; 41(4):723-30.
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  185. Barzilay J, Warram JH, Rand LI, Pfeifer MA, Krolewski AS. Risk for cardiovascular autonomic neuropathy is associated with the HLA-DR3/4 phenotype in type I diabetes mellitus. Ann Intern Med. 1992 Apr 1; 116(7):544-9.
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  186. Krolewski AS, Barzilay J, Warram JH, Martin BC, Pfeifer M, Rand LI. Risk of early-onset proliferative retinopathy in IDDM is closely related to cardiovascular autonomic neuropathy. Diabetes. 1992 Apr; 41(4):430-7.
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  187. Krolewski AS, Krolewski B, Gray M, Stanton V, Warram JH, Housman D. High-frequency DNA sequence polymorphisms in the insulin receptor gene detected by denaturing gradient gel blots. Genomics. 1992 Apr; 12(4):705-9.
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  188. Krolewski AS, Warram JH, Laffel LMB. Genetic susceptibility to diabetic nephropathy. Advances in Nephrol. 1992; 21:69-82.
  189. Krolewski AS, Warram JH, Laffel LM. Genetic susceptibility to diabetic nephropathy. Adv Nephrol Necker Hosp. 1992; 21:69-81.
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  190. Warram JH, Martin BC, Krolewski AS. Risk of IDDM in children of diabetic mothers decreases with increasing maternal age at pregnancy. Diabetes. 1991 Dec; 40(12):1679-84.
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  191. Manson JE, Rimm EB, Stampfer MJ, Colditz GA, Willett WC, Krolewski AS, Rosner B, Hennekens CH, Speizer FE. Physical activity and incidence of non-insulin-dependent diabetes mellitus in women. Lancet. 1991 Sep 28; 338(8770):774-8.
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  192. Valsania P, Zarich SW, Kowalchuk GJ, Kosinski E, Warram JH, Krolewski AS. Severity of coronary artery disease in young patients with insulin-dependent diabetes mellitus. Am Heart J. 1991 Sep; 122(3 Pt 1):695-700.
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  193. Warram JH, Laffel LM, Valsania P, Christlieb AR, Krolewski AS. Excess mortality associated with diuretic therapy in diabetes mellitus. Arch Intern Med. 1991 Jul; 151(7):1350-6.
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  194. Manson JE, Colditz GA, Stampfer MJ, Willett WC, Krolewski AS, Rosner B, Arky RA, Speizer FE, Hennekens CH. A prospective study of maturity-onset diabetes mellitus and risk of coronary heart disease and stroke in women. Arch Intern Med. 1991 Jun; 151(6):1141-7.
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  195. Laffel L, Warram JH, Krolewski AS. Increased blood pressure and erythrocyte sodium/lithium countertransport activity are not inherited in diabetic nephropathy. Diabetologia. 1991 Jun; 34(6):452-4.
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  196. Krolewski AS, Warram JH, Valsania P, Martin BC, Laffel LM, Christlieb AR. Evolving natural history of coronary artery disease in diabetes mellitus. Am J Med. 1991 Feb 21; 90(2A):56S-61S.
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  197. Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med. 1990 Dec 15; 113(12):909-15.
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  198. Krolewski AS, Warram JH. Natural history of diabetes mellitus. Principles and Practice of Endocrinology and Metabolism. Becker KL (ed.). 1990; 1084-87.
  199. Warram JH, Martin BC, Krolewski AS. Possible mechanisms for the diminished risk of IDDM in the children of diabetic mothers. Immunobiology of Normal and Diabetic Pregnancy. Andreani D, Bompiani G., DiMrio U, Faulk WP, Galluzo A (eds.). 1990; 221-8.
  200. Noth RH, Krolewski AS, Kaysen GA, Meyer TW, Schambelan M. Diabetic nephropathy: hemodynamic basis and implications for disease management. Ann Intern Med. 1989 May 15; 110(10):795-813.
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  201. Janka HU, Warram JH, Rand LI, Krolewski AS. Risk factors for progression of background retinopathy in long-standing IDDM. Diabetes. 1989 Apr; 38(4):460-4.
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  202. Laffel LMB, Krolewski AS. Epidemiology and clinical impact of diabetic late complications in IDDM. Prevention and Treatment of Diabetic Late Complications. Mogensen CE, Standl J (eds.). 1989; 13-27.
  203. Janka HU, Ziegler AG, Valsania P, Warram JH, Krolewski AS. Impact of blood pressure on diabetic retinopathy. Diabete Metab. 1989; 15(5 Pt 2):333-7.
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  204. Derby L, Warram JH, Laffel LM, Krolewski AS. Elevated blood pressure predicts the development of persistent proteinuria in the presence of poor glycemic control, in patients with type I diabetes. Diabete Metab. 1989; 15(5 Pt 2):320-6.
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  205. Krolewski AS, Warram JH. Current issues in the etiology of type 1 diabetes and its complications: an epidemiologic approach. Diabetes 1988. Larkins R, Zimmet P, Chisholm D (eds.). 1989; 321-4.
  206. Krolewski AS, Laffel L, Valsania P, Derby L, Warram J. Coronary artery disease in Type 1 diabetes mellitus and its determinants. Atherosclerosis VIII. Crepaldi et al. (eds.). 1989; 601-4.
  207. Savage MP, Krolewski AS, Kenien GG, Lebeis MP, Christlieb AR, Lewis SM. Acute myocardial infarction in diabetes mellitus and significance of congestive heart failure as a prognostic factor. Am J Cardiol. 1988 Oct 1; 62(10 Pt 1):665-9.
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  208. Warram JH, Krolewski AS, Kahn CR. Determinants of IDDM and perinatal mortality in children of diabetic mothers. Diabetes. 1988 Oct; 37(10):1328-34.
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  209. Krolewski AS, Canessa M, Warram JH, Laffel LM, Christlieb AR, Knowler WC, Rand LI. Predisposition to hypertension and susceptibility to renal disease in insulin-dependent diabetes mellitus. N Engl J Med. 1988 Jan 21; 318(3):140-5.
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  210. Warram JH, Martin BC, Soeldner JS, Krolewski AS. Study of glucose removal rate and first phase insulin secretion in the offspring of two parents with non-insulin-dependent diabetes. Adv Exp Med Biol. 1988; 246:175-9.
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  211. Christlieb AR, Krolewski AS, Warram JH. An update on hypertension in patients with diabetes mellitus. The Diabetes Annual/4. Alberti KGMM, Krall LP (eds.). 1988; 227-39.
  212. Kahn CR, Warram JH, Krolewski AS, Takayama S, Soeldner JS. Insulin resistance and non-insulin dependent diabetes mellitus. Pathogenesis of Non-Insulin Dependent Diabetes Mellitus. Grill V, Elfendic S (eds.). 1988; 227-39.
  213. Christlieb AR, Krolewski AS, Warram JH. Systemic hypertension, diabetes mellitus and the kidney. Am J Cardiol. 1987 Dec 14; 60(17):61I-65I.
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  214. Krolewski AS, Warram JH, Rand LI, Kahn CR. Epidemiologic approach to the etiology of type I diabetes mellitus and its complications. N Engl J Med. 1987 Nov 26; 317(22):1390-8.
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  215. Krolewski AS, Kosinski EJ, Warram JH, Leland OS, Busick EJ, Asmal AC, Rand LI, Christlieb AR, Bradley RF, Kahn CR. Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus. Am J Cardiol. 1987 Apr 1; 59(8):750-5.
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  216. Baker RS, Rand LI, Krolewski AS, Maki T, Warram JH, Aiello LM. Influence of HLA-DR phenotype and myopia on the risk of nonproliferative and proliferative diabetic retinopathy. Am J Ophthalmol. 1986 Dec 15; 102(6):693-700.
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  217. Krolewski AS, Warram JH, Rand LI, Christlieb AR, Busick EJ, Kahn CR. Risk of proliferative diabetic retinopathy in juvenile-onset type I diabetes: a 40-yr follow-up study. Diabetes Care. 1986 Sep-Oct; 9(5):443-52.
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  218. Rand LI, Krolewski AS, Warram JH. Late complications: the critical period. Diabetic Renal Syndrome: Prevention and Management. Freidman EA, L'Esperance FA (eds.). 1986; 297-99.
  219. Rand LI, Krolewski AS, Aiello LM, Warram JH, Baker RS, Maki T. Multiple factors in the prediction of risk of proliferative diabetic retinopathy. N Engl J Med. 1985 Dec 5; 313(23):1433-8.
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  220. Christlieb AR, Krolewski AS, Warram JH, Soeldner JS. Is insulin the link between hypertension and obesity? Hypertension. 1985 Nov-Dec; 7(6 Pt 2):II54-7.
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  221. Krolewski AS, Warram JH, Christlieb AR, Busick EJ, Kahn CR. The changing natural history of nephropathy in type I diabetes. Am J Med. 1985 May; 78(5):785-94.
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  222. Krolewski AS, Warram JH, Christlieb AR. Onset, course, complications and prognosis of diabetes mellitus. Joslin's Diabetes Mellitus, 12th Edition. Marble A, Bradley RF, Krall LP (eds.). 1985; 251-77.
  223. Krolewski AS, Warram JH, Cupples A, Gorman CK, Szabo AJ, Christlieb AR. Hypertension, orthostatic hypotension and the microvascular complications of diabetes. J Chronic Dis. 1985; 38(4):319-26.
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  224. Krolewski AS, Warram JH. Epidemiology of diabetes mellitus. Joslin's Diabetes Mellitus, 12th Edition. Marble A, Bradley RF, Krall LP (eds.). 1985; 21-58.
  225. Warram JH, Krolewski AS, Gottlieb MS, Kahn CR. Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. N Engl J Med. 1984 Jul 19; 311(3):149-52.
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  226. Janeczko D, Janeczko J, Królewski AS. [Viral hepatitis, blood HBs antigens and liver cirrhosis in patients with diabetes mellitus]. Pol Arch Med Wewn. 1983 Apr-May; 69(4-5):277-87.
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  227. Kopczynski J, Labanowska C, Borkowski W, Królewski A. [Prevention of arterial hypertension and the types of patient care in the Warsaw's Ochota residential district. I. Disease awareness and objectively determined incidence of the disease]. Kardiol Pol. 1983; 26(5):441-51.
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  228. Labanowska C, Kopczynski J, Borkowski W, Królewski A, Halik J. [Prevalence of arterial hypertension and the types of patient care in the Warsaw's Ochota residential district. II. Characteristic facts associated with the disease and the place of treatment]. Kardiol Pol. 1983; 26(5):453-60.
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  229. West KM, Ahuja MM, Bennett PH, Grab B, Grabauskas V, Mateo-de-Acosta O, Fuller JH, Jarrett RJ, Keen H, Kosaka K, Krolewski AS, Miki E, Schliack V, Teuscher A. Interrelationships of microangiopathy, plasma glucose and other risk factors in 3583 diabetic patients: a multinational study. Diabetologia. 1982 Jun; 22(6):412-20.
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  230. Jayyab AK, Heding LG, Czyzyk A, Malczewski B, Królewski AS. Serum C peptide and IRI levels after administration of glucagon and glucose in non-insulin-dependent diabetics. Horm Metab Res. 1982 Mar; 14(3):112-6.
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  231. Kopczynski J, Labanowska C, Królewski A, Borkowski W. [Health status of the population of a large city's residential area. II. Health status]. Przegl Epidemiol. 1982; 36(3-4):321-30.
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  232. Labanowska C, Kopczynski J, Królewski A, Borkowski W. [Health status of the population of a large city's residential area. I. Data collection and population characteristics]. Przegl Epidemiol. 1982; 36(3-4):311-9.
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  233. Królewski AS, Czyzyk A, Kopczynski J, Rywik S. Prevalence of diabetes mellitus, coronary heart disease and hypertension in the families of insulin dependent and insulin independent diabetics. Diabetologia. 1981 Dec; 21(6):520-4.
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  234. Christlieb AR, Warram JH, Krolewski AS, Busick EJ, Ganda OP, Asmal AC, Soeldner JS, Bradley RF. Hypertension: The major risk factor in juvenile-onset insulin-dependent diabetes. Diabetes. 1981; (30(Suppl.2)):90-6.
  235. Czyzk A, Królewski AS, Szablowska S, Alot A, Kopczynski J. Clinical course of myocardial infarction among diabetic patients. Diabetes Care. 1980 Jul-Aug; 3(4):526-9.
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  236. Krolewski AS, Kopczynski J, Kleszczewska J, Bogusz A. [Epidemiology of myocardial infarct in Warsaw in 1972]. Kardiol Pol. 1979; 22(1):55-63.
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  237. Wysocki M, Czyzyk A, Slonska Z, Krolewski A, Janeczko D. Health behaviour and its determinants among insulin-dependent diabetics. Results of the diabetes Warsaw study. Diabete Metab. 1978 Jun; 4(2):117-22.
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  238. Orøowksa K, Miedzinska-Szadkowska E, Przybylska-Dargiewicz Z, Królewski A, Gawdzinska-Grabowska H. [Pulmonary artery embolism as a cause of death]. Pol Tyg Lek. 1978 Mar 20; 33(12):465-8.
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  239. Puncewicz B, Ostrowska A, Wysocki M, Królewski A, Szewczynski J. [Analysis of nutrition in patients with juvenile diabetes mellitus. Results of the Warsaw diabetes study]. Pol Arch Med Wewn. 1978 Mar; 59(3):321-9.
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  240. Czyzyk A, Królewski AS, Gustowska I, Sobczynski J, Skowronska Z. [Effect of phenformin on heart rate and urinary catecholamine excretion (preliminary communication)]. Pol Arch Med Wewn. 1978 Mar; 59(3):255-60.
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  241. Królewski AS, Kopczynski J, Tyszko P. [Frequency of various surgical operations and use of hospital beds during postoperative period in Warsaw in 1972]. Pol Przegl Chir. 1978; 50(7):595-9.
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  242. Królewski AS, Czyzyk A, Janeczko D, Kopczynski J. Mortality from cardiovascular diseases among diabetics. Diabetologia. 1977 Aug; 13(4):345-50.
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  243. Czyzyk A, Muszynski J, Królewski AS. [Lactate coma in diabetes]. Pol Tyg Lek. 1977 May 23; 32(21):793-5.
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  244. Królewski AS, Kopczynski J. [Mortality from heart diseases in Warsaw in the years 1960-1974]. Kardiol Pol. 1977; 20(5):389-95.
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  245. Czyzyk A, Królewski AS. Is cigarette smoking more frequent among insulin-treated diabetics? Diabetes. 1976 Aug; 25(8):717-8.
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  246. Królewski AS, Janeczko D, Kobryn A, Puncewicz B. Survival after myocardial infarction in diabetic patients. Part I. Hospital mortality. Acta Med Pol. 1975; 16(1):45-52.
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  247. Królewski AS, Janeczko D, Kobryn A, Puncewicz B. Survival after myocardial infarction in diabetic patients. Part II. Hospital mortality in relation to the kind of hypoglycaemic treatment. Acta Med Pol. 1975; 16(1):53-9.
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  248. Czyzyk A, Brzezinski ZJ, Królewski AS, Janeczko D, Wysocki M, Puncewicz B. [Fate of diabetic patients. I. Methods of research and study group]. Przegl Epidemiol. 1975; 29(4):449-59.
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  249. Krolewski A, Rywik S. [Reproducibility of ECG evaluation in epidemiological studies]. Kardiol Pol. 1975; 18(5):433-8.
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