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Thorsten Roman Mempel, Ph.D., M.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
CIID, CNY 149, Room 8301
149 13th Street
Charlestown MA 02129
Phone617/724-4596
Fax617/726-5651

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lamphier M, Zheng W, Latz E, Spyvee M, Hansen H, Rose J, Genest M, Yang H, Shaffer C, Zhao Y, Shen Y, Liu C, Liu D, Mempel TR, Rowbottom C, Chow J, Twine NC, Yu M, Gusovsky F, Ishizaka ST. Novel Small Molecule Inhibitors of TLR7 and TLR9: Mechanism of Action and Efficacy In Vivo. Mol Pharmacol. 2014 Mar; 85(3):429-40.
    View in: PubMed
  2. Murooka TT, Mempel TR. Intravital Microscopy in BLT-Humanized Mice to Study Cellular Dynamics in HIV Infection. J Infect Dis. 2013 Nov; 208 Suppl 2:S137-44.
    View in: PubMed
  3. Henrickson SE, Perro M, Loughhead SM, Senman B, Stutte S, Quigley M, Alexe G, Iannacone M, Flynn MP, Omid S, Jesneck JL, Imam S, Mempel TR, Mazo IB, Haining WN, von Andrian UH. Antigen availability determines CD8(+) T cell-dendritic cell interaction kinetics and memory fate decisions. Immunity. 2013 Sep 19; 39(3):496-507.
    View in: PubMed
  4. Marangoni F, Murooka TT, Manzo T, Kim EY, Carrizosa E, Elpek NM, Mempel TR. The Transcription Factor NFAT Exhibits Signal Memory during Serial T Cell Interactions with Antigen-Presenting Cells. Immunity. 2013 Feb 21; 38(2):237-49.
    View in: PubMed
  5. Groom JR, Richmond J, Murooka TT, Sorensen EW, Sung JH, Bankert K, von Andrian UH, Moon JJ, Mempel TR, Luster AD. CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4(+) T Helper 1 Cell Differentiation. Immunity. 2012 Dec 14; 37(6):1091-103.
    View in: PubMed
  6. Murooka TT, Deruaz M, Marangoni F, Vrbanac VD, Seung E, von Andrian UH, Tager AM, Luster AD, Mempel TR. HIV-infected T cells are migratory vehicles for viral dissemination. Nature. 2012 Oct 11; 490(7419):283-7.
    View in: PubMed
  7. Ignatius MS, Chen E, Elpek NM, Fuller AZ, Tenente IM, Clagg R, Liu S, Blackburn JS, Linardic CM, Rosenberg AE, Nielsen PG, Mempel TR, Langenau DM. In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma. Cancer Cell. 2012 May 15; 21(5):680-93.
    View in: PubMed
  8. Murooka TT, Mempel TR. Multiphoton intravital microscopy to study lymphocyte motility in lymph nodes. Methods Mol Biol. 2012; 757:247-57.
    View in: PubMed
  9. Mempel TR. Single-cell analysis of cytotoxic T cell function by intravital multiphoton microscopy. Methods Mol Biol. 2010; 616:181-92.
    View in: PubMed
  10. Barrington RA, Schneider TJ, Pitcher LA, Mempel TR, Ma M, Barteneva NS, Carroll MC. Uncoupling CD21 and CD19 of the B-cell coreceptor. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14490-5.
    View in: PubMed
  11. Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009 Jul 31; 325(5940):612-6.
    View in: PubMed
  12. Gonzalez SF, Pitcher LA, Mempel T, Schuerpf F, Carroll MC. B cell acquisition of antigen in vivo. Curr Opin Immunol. 2009 Jun; 21(3):251-7.
    View in: PubMed
  13. Leimgruber A, Berger C, Cortez-Retamozo V, Etzrodt M, Newton AP, Waterman P, Figueiredo JL, Kohler RH, Elpek N, Mempel TR, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ. Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle. Neoplasia. 2009 May; 11(5):459-68, 2 p following 468.
    View in: PubMed
  14. Roozendaal R, Mempel TR, Pitcher LA, Gonzalez SF, Verschoor A, Mebius RE, von Andrian UH, Carroll MC. Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity. 2009 Feb 20; 30(2):264-76.
    View in: PubMed
  15. Mempel TR, Marangoni F. CD44 keeps tumor killers polarized. Immunity. 2008 Dec 19; 29(6):843-5.
    View in: PubMed
  16. Sakadzic S, Demirbas U, Mempel TR, Moore A, Ruvinskaya S, Boas DA, Sennaroglu A, Kaertner FX, Fujimoto JG. Multi-photon microscopy with a low-cost and highly efficient Cr:LiCAF laser. Opt Express. 2008 Dec 8; 16(25):20848-63.
    View in: PubMed
  17. Bromley SK, Mempel TR, Luster AD. Orchestrating the orchestrators: chemokines in control of T cell traffic. Nat Immunol. 2008 Sep; 9(9):970-80.
    View in: PubMed
  18. Mempel TR, Bauer CA. Intravital imaging of CD8+ T cell function in cancer. Clin Exp Metastasis. 2009; 26(4):311-27.
    View in: PubMed
  19. Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, Peixoto A, Flynn M, Senman B, Junt T, Wong HC, Chakraborty AK, von Andrian UH. In vivo imaging of T cell priming. Sci Signal. 2008; 1(12):pt2.
    View in: PubMed
  20. Pittet MJ, Mempel TR. Regulation of T-cell migration and effector functions: insights from in vivo imaging studies. Immunol Rev. 2008 Feb; 221:107-29.
    View in: PubMed
  21. Henrickson SE, Mempel TR, Mazo IB, Liu B, Artyomov MN, Zheng H, Peixoto A, Flynn MP, Senman B, Junt T, Wong HC, Chakraborty AK, von Andrian UH. T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation. Nat Immunol. 2008 Mar; 9(3):282-91.
    View in: PubMed
  22. Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R. A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses. PLoS One. 2007; 2(10):e1075.
    View in: PubMed
  23. Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, van Rooijen N, Mempel TR, Whelan SP, von Andrian UH. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature. 2007 Nov 1; 450(7166):110-4.
    View in: PubMed
  24. Bonasio R, Carman CV, Kim E, Sage PT, Love KR, Mempel TR, Springer TA, von Andrian UH. Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14753-8.
    View in: PubMed
  25. Hauser AE, Junt T, Mempel TR, Sneddon MW, Kleinstein SH, Henrickson SE, von Andrian UH, Shlomchik MJ, Haberman AM. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity. 2007 May; 26(5):655-67.
    View in: PubMed
  26. Worbs T, Mempel TR, Bölter J, von Andrian UH, Förster R. CCR7 ligands stimulate the intranodal motility of T lymphocytes in vivo. J Exp Med. 2007 Mar 19; 204(3):489-95.
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  27. Nombela-Arrieta C, Mempel TR, Soriano SF, Mazo I, Wymann MP, Hirsch E, Martínez-A C, Fukui Y, von Andrian UH, Stein JV. A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. J Exp Med. 2007 Mar 19; 204(3):497-510.
    View in: PubMed
  28. Mempel TR, Junt T, von Andrian UH. Rulers over randomness: stroma cells guide lymphocyte migration in lymph nodes. Immunity. 2006 Dec; 25(6):867-9.
    View in: PubMed
  29. Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Andrian UH. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity. 2006 Jul; 25(1):129-41.
    View in: PubMed
  30. Halin C, Scimone ML, Bonasio R, Gauguet JM, Mempel TR, Quackenbush E, Proia RL, Mandala S, von Andrian UH. The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. Blood. 2005 Aug 15; 106(4):1314-22.
    View in: PubMed
  31. Thurau SR, Mempel TR, Flügel A, Diedrichs-Möhring M, Krombach F, Kawakami N, Wildner G. The fate of autoreactive, GFP+ T cells in rat models of uveitis analyzed by intravital fluorescence microscopy and FACS. Int Immunol. 2004 Nov; 16(11):1573-82.
    View in: PubMed
  32. Sumen C, Mempel TR, Mazo IB, von Andrian UH. Intravital microscopy: visualizing immunity in context. Immunity. 2004 Sep; 21(3):315-29.
    View in: PubMed
  33. Mempel TR, Scimone ML, Mora JR, von Andrian UH. In vivo imaging of leukocyte trafficking in blood vessels and tissues. Curr Opin Immunol. 2004 Aug; 16(4):406-17.
    View in: PubMed
  34. Mempel TR, Henrickson SE, Von Andrian UH. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature. 2004 Jan 8; 427(6970):154-9.
    View in: PubMed
  35. M'Rini C, Cheng G, Schweitzer C, Cavanagh LL, Palframan RT, Mempel TR, Warnock RA, Lowe JB, Quackenbush EJ, von Andrian UH. A novel endothelial L-selectin ligand activity in lymph node medulla that is regulated by alpha(1,3)-fucosyltransferase-IV. J Exp Med. 2003 Nov 3; 198(9):1301-12.
    View in: PubMed
  36. von Andrian UH, Mempel TR. Homing and cellular traffic in lymph nodes. Nat Rev Immunol. 2003 Nov; 3(11):867-78.
    View in: PubMed
  37. Mempel TR, Moser C, Hutter J, Kuebler WM, Krombach F. Visualization of leukocyte transendothelial and interstitial migration using reflected light oblique transillumination in intravital video microscopy. J Vasc Res. 2003 Sep-Oct; 40(5):435-41.
    View in: PubMed
  38. Till H, Metzger R, Mempel T, Boehm R, Joppich I. Proliferation, zonal maturation, and steroid production of fetal adrenal transplants in adrenalectomized rats. Pediatr Surg Int. 2000; 16(4):293-6.
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  39. Metzger R, Mempel T, Joppich I, Till H. Organ-specific distribution of major histocompatibility antigens in rats. Pediatr Surg Int. 2000; 16(4):285-92.
    View in: PubMed
  40. Massoudy P, Mempel T, Raschke P, Becker BF. Reduction of oxygen delivery during post-ischemic reperfusion protects the isolated guinea pig heart. Basic Res Cardiol. 1999 Aug; 94(4):231-7.
    View in: PubMed
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