Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Ursula Brigitte Kaiser, M.D.

TitleProfessor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Endocrine RFB 296
221 Longwood Ave
Boston MA 02115
Phone617/525-8867
Fax617/264-5273

 Mentoring 
 current student opportunities
Available: 09/03/13, Expires: 08/29/14

Our laboratory uses a translational approach to study the hormones involved in the neuroendocrine regulation of reproductive development and function. We use a wide range of approaches, from bedside to bench and back, to study the molecular and physiologic mechanisms underlying the regulation of gonadotropin-releasing hormone (GnRH) and gonadotropin synthesis. These include: 1. hypothalamic and pituitary cell models and in vitro studies; 2. In vivo mouse models; and 3. studies of patients with clinical reproductive disorders. Research opportunities exist for students to participate in our studies to: (1) learn and perform many techniques of molecular and cellular biology; (2) learn to apply molecular biology to the study of physiology and clinical disorders; and (3) obtain a better understanding of the regulation of puberty and reproduction in a translational setting.

 completed student projects
Gonadatropin Gene Expression; Reproductive Endocrinology
Summer, 06/08/00 - 08/26/00

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Min L, Soltis K, Reis AC, Xu S, Kuohung W, Jain M, Carroll RS, Kaiser UB. Dynamic kisspeptin receptor trafficking modulates kisspeptin-mediated calcium signaling. Mol Endocrinol. 2014 Jan; 28(1):16-27.
    View in: PubMed
  2. Magill JC, Ciccone NA, Kaiser UB. A mathematical model of pulse-coded hormone signal responses in pituitary gonadotroph cells. Math Biosci. 2013 Nov; 246(1):38-46.
    View in: PubMed
  3. Navarro VM, Kaiser UB. Metabolic influences on neuroendocrine regulation of reproduction. Curr Opin Endocrinol Diabetes Obes. 2013 Aug; 20(4):335-41.
    View in: PubMed
  4. Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC, Cukier P, Thompson IR, Navarro VM, Gagliardi PC, Rodrigues T, Kochi C, Longui CA, Beckers D, de Zegher F, Montenegro LR, Mendonca BB, Carroll RS, Hirschhorn JN, Latronico AC, Kaiser UB. Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med. 2013 Jun 27; 368(26):2467-75.
    View in: PubMed
  5. Thompson IR, Ciccone NA, Xu S, Zaytseva S, Carroll RS, Kaiser UB. GnRH Pulse Frequency-Dependent Stimulation of FSHß Transcription Is Mediated via Activation of PKA and CREB. Mol Endocrinol. 2013 Apr; 27(4):606-18.
    View in: PubMed
  6. Bianco SD, Kaiser UB. Molecular biology of the kisspeptin receptor: signaling, function, and mutations. Adv Exp Med Biol. 2013; 784:133-58.
    View in: PubMed
  7. Fang R, Chen F, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y, Shi YG. LSD2/KDM1B and Its Cofactor NPAC/GLYR1 Endow a Structural and Molecular Model for Regulation of H3K4 Demethylation. Mol Cell. 2013 Feb 7; 49(3):558-70.
    View in: PubMed
  8. Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YG. Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development. Cell. 2012 Dec 7; 151(6):1200-13.
    View in: PubMed
  9. Tusset C, Noel SD, Trarbach EB, Silveira LF, Jorge AA, Brito VN, Cukier P, Seminara SB, Mendonça BB, Kaiser UB, Latronico AC. Mutational analysis of TAC3 and TACR3 genes in patients with idiopathic central pubertal disorders. Arq Bras Endocrinol Metabol. 2012 Dec; 56(9):646-52.
    View in: PubMed
  10. Babwah AV, Pampillo M, Min L, Kaiser UB, Bhattacharya M. Single-Cell Analyses Reveal That KISS1R-Expressing Cells Undergo Sustained Kisspeptin-Induced Signaling That Is Dependent upon An Influx of Extracellular Ca2+. Endocrinology. 2012 Dec; 153(12):5875-87.
    View in: PubMed
  11. Kaiser UB. Hyperprolactinemia and infertility: new insights. J Clin Invest. 2012 Oct 1; 122(10):3467-8.
    View in: PubMed
  12. Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YG. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell. 2012 Sep 14; 150(6):1135-46.
    View in: PubMed
  13. Gill JC, Navarro VM, Kwong C, Noel SD, Martin C, Xu S, Clifton DK, Carroll RS, Steiner RA, Kaiser UB. Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1. Endocrinology. 2012 Oct; 153(10):4883-93.
    View in: PubMed
  14. Gianetti E, Hall JE, Au MG, Kaiser UB, Quinton R, Stewart JA, Metzger DL, Pitteloud N, Mericq V, Merino PM, Levitsky LL, Izatt L, Lang-Muritano M, Fujimoto VY, Dluhy RG, Chase ML, Crowley WF, Plummer L, Seminara SB. When genetic load does not correlate with phenotypic spectrum: lessons from the GnRH receptor (GNRHR). J Clin Endocrinol Metab. 2012 Sep; 97(9):E1798-807.
    View in: PubMed
  15. Abreu AP, Noel SD, Xu S, Carroll RS, Latronico AC, Kaiser UB. Evidence of the importance of the first intracellular loop of prokineticin receptor 2 in receptor function. Mol Endocrinol. 2012 Aug; 26(8):1417-27.
    View in: PubMed
  16. Chan YM, Broder-Fingert S, Paraschos S, Lapatto R, Au M, Hughes V, Bianco SD, Min L, Plummer L, Cerrato F, De Guillebon A, Wu IH, Wahab F, Dwyer A, Kirsch S, Quinton R, Cheetham T, Ozata M, Ten S, Chanoine JP, Pitteloud N, Martin KA, Schiffmann R, Van der Kamp HJ, Nader S, Hall JE, Kaiser UB, Seminara SB. GnRH-deficient phenotypes in humans and mice with heterozygous variants in KISS1/Kiss1. J Clin Endocrinol Metab. 2011 Nov; 96(11):E1771-81.
    View in: PubMed
  17. Noel SD, Kaiser UB. G protein-coupled receptors involved in GnRH regulation: molecular insights from human disease. Mol Cell Endocrinol. 2011 Oct 22; 346(1-2):91-101.
    View in: PubMed
  18. Vaidya A, Kaiser UB, Levy BD, Loscalzo J. Clinical problem-solving. Lying low. N Engl J Med. 2011 Mar 3; 364(9):871-5.
    View in: PubMed
  19. Ross JJ, Vaidya A, Kaiser UB. Interactive medical case. Lying low. N Engl J Med. 2011 Feb 10; 364(6):e10.
    View in: PubMed
  20. Bianco SD, Vandepas L, Correa-Medina M, Gereben B, Mukherjee A, Kuohung W, Carroll R, Teles MG, Latronico AC, Kaiser UB. KISS1R intracellular trafficking and degradation: effect of the Arg386Pro disease-associated mutation. Endocrinology. 2011 Apr; 152(4):1616-26.
    View in: PubMed
  21. Martin C, Balasubramanian R, Dwyer AA, Au MG, Sidis Y, Kaiser UB, Seminara SB, Pitteloud N, Zhou QY, Crowley WF. The role of the prokineticin 2 pathway in human reproduction: evidence from the study of human and murine gene mutations. Endocr Rev. 2011 Apr; 32(2):225-46.
    View in: PubMed
  22. Zada G, Tirosh A, Kaiser UB, Laws ER, Woodmansee WW. Cushing's disease and idiopathic intracranial hypertension: case report and review of underlying pathophysiological mechanisms. J Clin Endocrinol Metab. 2010 Nov; 95(11):4850-4.
    View in: PubMed
  23. Gill JC, Wang O, Kakar S, Martinelli E, Carroll RS, Kaiser UB. Reproductive hormone-dependent and -independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice. PLoS One. 2010; 5(7):e11911.
    View in: PubMed
  24. Fang R, Barbera AJ, Xu Y, Rutenberg M, Leonor T, Bi Q, Lan F, Mei P, Yuan GC, Lian C, Peng J, Cheng D, Sui G, Kaiser UB, Shi Y, Shi YG. Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. Mol Cell. 2010 Jul 30; 39(2):222-33.
    View in: PubMed
  25. Balasubramanian R, Dwyer A, Seminara SB, Pitteloud N, Kaiser UB, Crowley WF. Human GnRH deficiency: a unique disease model to unravel the ontogeny of GnRH neurons. Neuroendocrinology. 2010; 92(2):81-99.
    View in: PubMed
  26. Hamnvik OP, Laury AR, Laws ER, Kaiser UB. Lymphocytic hypophysitis with diabetes insipidus in a young man. Nat Rev Endocrinol. 2010 Aug; 6(8):464-70.
    View in: PubMed
  27. Abreu AP, Kaiser UB, Latronico AC. The role of prokineticins in the pathogenesis of hypogonadotropic hypogonadism. Neuroendocrinology. 2010; 91(4):283-90.
    View in: PubMed
  28. Sykiotis GP, Pitteloud N, Seminara SB, Kaiser UB, Crowley WF. Deciphering genetic disease in the genomic era: the model of GnRH deficiency. Sci Transl Med. 2010 May 19; 2(32):32rv2.
    View in: PubMed
  29. Kuohung W, Burnett M, Mukhtyar D, Schuman E, Ni J, Crowley WF, Glicksman MA, Kaiser UB. A high-throughput small-molecule ligand screen targeted to agonists and antagonists of the G-protein-coupled receptor GPR54. J Biomol Screen. 2010 Jun; 15(5):508-17.
    View in: PubMed
  30. Teles MG, Trarbach EB, Noel SD, Guerra-Junior G, Jorge A, Beneduzzi D, Bianco SD, Mukherjee A, Baptista MT, Costa EM, De Castro M, Mendonça BB, Kaiser UB, Latronico AC. A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism. Eur J Endocrinol. 2010 Jul; 163(1):29-34.
    View in: PubMed
  31. Gianetti E, Tusset C, Noel SD, Au MG, Dwyer AA, Hughes VA, Abreu AP, Carroll J, Trarbach E, Silveira LF, Costa EM, de Mendonça BB, de Castro M, Lofrano A, Hall JE, Bolu E, Ozata M, Quinton R, Amory JK, Stewart SE, Arlt W, Cole TR, Crowley WF, Kaiser UB, Latronico AC, Seminara SB. TAC3/TACR3 mutations reveal preferential activation of gonadotropin-releasing hormone release by neurokinin B in neonatal life followed by reversal in adulthood. J Clin Endocrinol Metab. 2010 Jun; 95(6):2857-67.
    View in: PubMed
  32. Silveira LG, Noel SD, Silveira-Neto AP, Abreu AP, Brito VN, Santos MG, Bianco SD, Kuohung W, Xu S, Gryngarten M, Escobar ME, Arnhold IJ, Mendonca BB, Kaiser UB, Latronico AC. Mutations of the KISS1 gene in disorders of puberty. J Clin Endocrinol Metab. 2010 May; 95(5):2276-80.
    View in: PubMed
  33. Chamarthi B, Morris CA, Kaiser UB, Katz JT, Loscalzo J. Clinical problem-solving. Stalking the diagnosis. N Engl J Med. 2010 Mar 4; 362(9):834-9.
    View in: PubMed
  34. Ciccone NA, Xu S, Lacza CT, Carroll RS, Kaiser UB. Frequency-dependent regulation of follicle-stimulating hormone beta by pulsatile gonadotropin-releasing hormone is mediated by functional antagonism of bZIP transcription factors. Mol Cell Biol. 2010 Feb; 30(4):1028-40.
    View in: PubMed
  35. Raivio T, Sidis Y, Plummer L, Chen H, Ma J, Mukherjee A, Jacobson-Dickman E, Quinton R, Van Vliet G, Lavoie H, Hughes VA, Dwyer A, Hayes FJ, Xu S, Sparks S, Kaiser UB, Mohammadi M, Pitteloud N. Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2009 Nov; 94(11):4380-90.
    View in: PubMed
  36. Bianco SD, Kaiser UB. The genetic and molecular basis of idiopathic hypogonadotropic hypogonadism. Nat Rev Endocrinol. 2009 Oct; 5(10):569-76.
    View in: PubMed
  37. Ciccone NA, Kaiser UB. The biology of gonadotroph regulation. Curr Opin Endocrinol Diabetes Obes. 2009 Aug; 16(4):321-7.
    View in: PubMed
  38. Jeong KH, Gill JC, Nosé V, Parlow AF, Carroll RS, Kaiser UB. Expression of a gonadotropin-releasing hormone receptor-simian virus 40 T-antigen transgene has sex-specific effects on the reproductive axis. Endocrinology. 2009 Jul; 150(7):3383-91.
    View in: PubMed
  39. Ciccone NA, Lacza CT, Hou MY, Gregory SJ, Kam KY, Xu S, Kaiser UB. A composite element that binds basic helix loop helix and basic leucine zipper transcription factors is important for gonadotropin-releasing hormone regulation of the follicle-stimulating hormone beta gene. Mol Endocrinol. 2008 Aug; 22(8):1908-23.
    View in: PubMed
  40. Kaiser UB. Genetic labeling: new approaches to creating a gonadotroph "ID". Endocrinology. 2008 Jun; 149(6):2699-700.
    View in: PubMed
  41. Gill JC, Wadas B, Chen P, Portillo W, Reyna A, Jorgensen E, Mani S, Schwarting GA, Moenter SM, Tobet S, Kaiser UB. The gonadotropin-releasing hormone (GnRH) neuronal population is normal in size and distribution in GnRH-deficient and GnRH receptor-mutant hypogonadal mice. Endocrinology. 2008 Sep; 149(9):4596-604.
    View in: PubMed
  42. Teles MG, Bianco SD, Brito VN, Trarbach EB, Kuohung W, Xu S, Seminara SB, Mendonca BB, Kaiser UB, Latronico AC. A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med. 2008 Feb 14; 358(7):709-15.
    View in: PubMed
  43. Bédécarrats GY, Kaiser UB. Mutations in the human gonadotropin-releasing hormone receptor: insights into receptor biology and function. Semin Reprod Med. 2007 Sep; 25(5):368-78.
    View in: PubMed
  44. Cogliati T, Delgado-Romero P, Norwitz ER, Guduric-Fuchs J, Kaiser UB, Wray S, Kirsch IR. Pubertal impairment in Nhlh2 null mice is associated with hypothalamic and pituitary deficiencies. Mol Endocrinol. 2007 Dec; 21(12):3013-27.
    View in: PubMed
  45. Jeong KH, Bakowska JC, Song IO, Fu N, Breakefield XO, Kaiser UB. Improvement in reproductive parameters in hypogonadal female mice by regulated gene replacement therapy in the central nervous system. Gene Ther. 2007 Jul; 14(14):1092-101.
    View in: PubMed
  46. Sell H, Kaiser U, Eckel J. Expression of chemokine receptors in insulin-resistant human skeletal muscle cells. Horm Metab Res. 2007 Apr; 39(4):244-9.
    View in: PubMed
  47. Kuohung W, Kaiser UB. GPR54 and KiSS-1: role in the regulation of puberty and reproduction. Rev Endocr Metab Disord. 2006 Dec; 7(4):257-63.
    View in: PubMed
  48. Boehme V, Zeynalova S, Kloess M, Loeffler M, Kaiser U, Pfreundschuh M, Schmitz N. Incidence and risk factors of central nervous system recurrence in aggressive lymphoma--a survey of 1693 patients treated in protocols of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). Ann Oncol. 2007 Jan; 18(1):149-57.
    View in: PubMed
  49. Chattopadhyay N, Jeong KH, Yano S, Huang S, Pang JL, Ren X, Terwilliger E, Kaiser UB, Vassilev PM, Pollak MR, Brown EM. Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice. Am J Physiol Endocrinol Metab. 2007 Feb; 292(2):E523-32.
    View in: PubMed
  50. Mazhawidza W, Winters SJ, Kaiser UB, Kakar SS. Identification of gene networks modulated by activin in LbetaT2 cells using DNA microarray analysis. Histol Histopathol. 2006 Feb; 21(2):167-78.
    View in: PubMed
  51. Kuohung W, Kaiser UB. GPR54 and KiSS-1: Role in the regulation of puberty and reproduction. Reviews in Endocrine and Metabolic Disorders. 2006.
  52. Kanasaki H, Bedecarrats GY, Kam KY, Xu S, Kaiser UB. Gonadotropin-releasing hormone pulse frequency-dependent activation of extracellular signal-regulated kinase pathways in perifused LbetaT2 cells. Endocrinology. 2005 Dec; 146(12):5503-13.
    View in: PubMed
  53. Kaiser UB, Kuohung W. KiSS-1 and GPR54 as new players in gonadotropin regulation and puberty. Endocrine. 2005 Apr; 26(3):277-84.
    View in: PubMed
  54. Seminara SB, Kaiser UB. New gatekeepers of reproduction: GPR54 and its cognate ligand, KiSS-1. Endocrinology. 2005 Apr; 146(4):1686-8.
    View in: PubMed
  55. Kuohung W, Kaiser UB. GnRH and gonadotrpins. In Jameson JL and DeGroote, eds. Endocrinology. 2005.
  56. Jeong KH, Kaiser UB. GnRH regulation of gonadotropion biosynthesis and secretion. In: Knobil and Neill, eds. The Physiology of Reproduction. 2005.
  57. Pask AJ, Kanasaki H, Kaiser UB, Conn PM, Janovick JA, Stockton DW, Hess DL, Justice MJ, Behringer RR. A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. Mol Endocrinol. 2005 Apr; 19(4):972-81.
    View in: PubMed
  58. Kam KY, Jeong KH, Norwitz ER, Jorgensen EM, Kaiser UB. Oct-1 and nuclear factor Y bind to the SURG-1 element to direct basal and gonadotropin-releasing hormone (GnRH)-stimulated mouse GnRH receptor gene transcription. Mol Endocrinol. 2005 Jan; 19(1):148-62.
    View in: PubMed
  59. Gregory SJ, Lacza CT, Detz AA, Xu S, Petrillo LA, Kaiser UB. Synergy between activin A and gonadotropin-releasing hormone in transcriptional activation of the rat follicle-stimulating hormone-beta gene. Mol Endocrinol. 2005 Jan; 19(1):237-54.
    View in: PubMed
  60. Gregory SJ, Kaiser UB. Regulation of gonadotropins by inhibin and activin. Semin Reprod Med. 2004 Aug; 22(3):253-67.
    View in: PubMed
  61. Jeong KH, Chin WW, Kaiser UB. Essential role of the homeodomain for pituitary homeobox 1 activation of mouse gonadotropin-releasing hormone receptor gene expression through interactions with c-Jun and DNA. Mol Cell Biol. 2004 Jul; 24(14):6127-39.
    View in: PubMed
  62. Meysing AU, Kanasaki H, Bedecarrats GY, Acierno JS, Conn PM, Martin KA, Seminara SB, Hall JE, Crowley WF, Kaiser UB. GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone. J Clin Endocrinol Metab. 2004 Jul; 89(7):3189-98.
    View in: PubMed
  63. Gregory SJ, Kaiser UB. Regulation of gonadotropins by inhibin and activin. Seminara SB, Kaiser UB. 2004; 22:253-67.
  64. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF, Aparicio SA, Colledge WH. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003 Oct 23; 349(17):1614-27.
    View in: PubMed
  65. Kaiser UB. The pathogenesis of the ovarian hyperstimulation syndrome. N Engl J Med. 2003 Aug 21; 349(8):729-32.
    View in: PubMed
  66. Bédécarrats GY, Linher KD, Janovick JA, Beranova M, Kada F, Seminara SB, Michael Conn P, Kaiser UB. Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor function. Mol Cell Endocrinol. 2003 Jul 31; 205(1-2):51-64.
    View in: PubMed
  67. Bédécarrats GY, O'Neill FH, Norwitz ER, Kaiser UB, Teixeira J. Regulation of gonadotropin gene expression by Mullerian inhibiting substance. Proc Natl Acad Sci U S A. 2003 Aug 5; 100(16):9348-53.
    View in: PubMed
  68. Bédécarrats GY, Kaiser UB. Differential regulation of gonadotropin subunit gene promoter activity by pulsatile gonadotropin-releasing hormone (GnRH) in perifused L beta T2 cells: role of GnRH receptor concentration. Endocrinology. 2003 May; 144(5):1802-11.
    View in: PubMed
  69. Bedecarrats GY, Linher KD, Kaiser UB. Two common naturally occurring mutations in the human gonadotropin-releasing hormone (GnRH) receptor have differential effects on gonadotropin gene expression and on GnRH-mediated signal transduction. J Clin Endocrinol Metab. 2003 Feb; 88(2):834-43.
    View in: PubMed
  70. Kaiser UB. Perspective: Pathogenesis of ovarian hyperstimulation syndrome: insights from FSH receptor mutations. New Engl J Med. 2003; 349:729-32.
  71. Zakaria MM, Jeong KH, Lacza C, Kaiser UB. Pituitary homeobox 1 activates the rat FSHbeta (rFSHbeta) gene through both direct and indirect interactions with the rFSHbeta gene promoter. Mol Endocrinol. 2002 Aug; 16(8):1840-52.
    View in: PubMed
  72. Norwitz ER, Xu S, Xu J, Spiryda LB, Park JS, Jeong KH, McGee EA, Kaiser UB. Direct binding of AP-1 (Fos/Jun) proteins to a SMAD binding element facilitates both gonadotropin-releasing hormone (GnRH)- and activin-mediated transcriptional activation of the mouse GnRH receptor gene. J Biol Chem. 2002 Oct 4; 277(40):37469-78.
    View in: PubMed
  73. Norwitz ER, Xu S, Jeong KH, Bédécarrats GY, Winebrenner LD, Chin WW, Kaiser UB. Activin A augments GnRH-mediated transcriptional activation of the mouse GnRH receptor gene. Endocrinology. 2002 Mar; 143(3):985-97.
    View in: PubMed
  74. Costa EM, Bedecarrats GY, Mendonca BB, Arnhold IJ, Kaiser UB, Latronico AC. Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction. J Clin Endocrinol Metab. 2001 Jun; 86(6):2680-6.
    View in: PubMed
  75. Beranova M, Oliveira LM, Bédécarrats GY, Schipani E, Vallejo M, Ammini AC, Quintos JB, Hall JE, Martin KA, Hayes FJ, Pitteloud N, Kaiser UB, Crowley WF, Seminara SB. Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2001 Apr; 86(4):1580-8.
    View in: PubMed
  76. Kaiser U. Pituitary gene therapy--hypotheses on the hypophysis. Endocrinology. 2001 Feb; 142(2):528-31.
    View in: PubMed
  77. Kaiser UB, Hedley-Whyte ET. Weekly clinicopathological excerises: Case 15-2001: A 72-year old man with persistent fever and hypotension. New Engl J Med. 2001; 344:1536-42.
  78. Kaiser UB, Halvorson LM, Chen MT. Sp1, steroidogenic factor 1 (SF-1), and early growth response protein 1 (egr-1) binding sites form a tripartite gonadotropin-releasing hormone response element in the rat luteinizing hormone-beta gene promoter: an integral role for SF-1. Mol Endocrinol. 2000 Aug; 14(8):1235-45.
    View in: PubMed
  79. Kaiser UB. Neuroendocrinology: editorial overview. Curr Opin Endocrinol and Diab. 2000; 7:151-2.
  80. Halvorson LM, Kaiser UB, Chin WW. The protein kinase C system acts through the early growth response protein 1 to increase LHbeta gene expression in synergy with steroidogenic factor-1. Mol Endocrinol. 1999 Jan; 13(1):106-16.
    View in: PubMed
  81. Kaiser UB. Molecular mechanisms of the regulation of gonadotropin gene expression by gonadotropin-releasing hormone. Mol Cells. 1998 Dec 31; 8(6):647-56.
    View in: PubMed
  82. Mitsumori M, Shrieve DC, Alexander E, Kaiser UB, Richardson GE, Black PM, Loeffler JS. Initial clinical results of LINAC-based stereotactic radiosurgery and stereotactic radiotherapy for pituitary adenomas. Int J Radiat Oncol Biol Phys. 1998 Oct 1; 42(3):573-80.
    View in: PubMed
  83. Kaiser UB, Sabbagh E, Chen MT, Chin WW, Saunders BD. Sp1 binds to the rat luteinizing hormone beta (LHbeta) gene promoter and mediates gonadotropin-releasing hormone-stimulated expression of the LHbeta subunit gene. J Biol Chem. 1998 May 22; 273(21):12943-51.
    View in: PubMed
  84. Kaiser UB, Sabbagh E, Saunders BD, Chin WW. Identification of cis-acting deoxyribonucleic acid elements that mediate gonadotropin-releasing hormone stimulation of the rat luteinizing hormone beta-subunit gene. Endocrinology. 1998 May; 139(5):2443-51.
    View in: PubMed
  85. Saunders BD, Sabbagh E, Chin WW, Kaiser UB. Differential use of signal transduction pathways in the gonadotropin-releasing hormone-mediated regulation of gonadotropin subunit gene expression. Endocrinology. 1998 Apr; 139(4):1835-43.
    View in: PubMed
  86. Mitsumori M, Shrieve DC, Alexander K, Kaiser UB, Richardson GE, Black PM, Loeffler JS. Initial clinical results of LINAC-based stereotactic radiosurgery and sterostatic radiotherapy for pituitary ademomas. Int J Radiation Oncology Biol Phys. 1998; 42:573-80.
  87. Kaiser UB, Jakubowiak A, Steinberger A, Chin WW. Differential effects of gonadotropin-releasing hormone (GnRH) pulse frequency on gonadotropin subunit and GnRH receptor messenger ribonucleic acid levels in vitro. Endocrinology. 1997 Mar; 138(3):1224-31.
    View in: PubMed
  88. Wimmel A, Schilli M, Kaiser U, Havemann K, Ramaswamy A, Branscheid D, Kogan E, Schuermann M. Preferential histiotypic expression of CD44-isoforms in human lung cancer. Lung Cancer. 1997 Mar; 16(2-3):151-72.
    View in: PubMed
  89. Kaiser UB, Conn PM, Chin WW. Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines. Endocr Rev. 1997 Feb; 18(1):46-70.
    View in: PubMed
  90. Kaiser UB, Jakubowiak A, Steinberger A, Chin WW. Differential effects of gonaadotropin-releasing hormone pulse frequency on gonadotropin subunit and gonadotropin-releasing hormone receptor mRNA levels in vitro. Endocrinology. 1997; 138:1224-31.
  91. Penabad JL, Bashey HM, Asa SL, Haddad G, Davis KD, Herbst AB, Gennarelli TA, Kaiser UB, Chin WW, Snyder PJ. Decreased follistatin gene expression in gonadotroph adenomas. J Clin Endocrinol Metab. 1996 Sep; 81(9):3397-403.
    View in: PubMed
  92. Kaiser U, Hofmann J, Schilli M, Wegmann B, Klotz U, Wedel S, Virmani AK, Wollmer E, Branscheid D, Gazdar AF, Havemann K. Steroid-hormone receptors in cell lines and tumor biopsies of human lung cancer. Int J Cancer. 1996 Jul 29; 67(3):357-64.
    View in: PubMed
  93. Fernández-Vázquez G, Kaiser UB, Albarracin CT, Chin WW. Transcriptional activation of the gonadotropin-releasing hormone receptor gene by activin A. Mol Endocrinol. 1996 Apr; 10(4):356-66.
    View in: PubMed
  94. Halvorson LM, Kaiser UB, Chin WW. Stimulation of luteinizing hormone beta gene promoter activity by the orphan nuclear receptor, steroidogenic factor-1. J Biol Chem. 1996 Mar 22; 271(12):6645-50.
    View in: PubMed
  95. Stricker H, Kaiser U, Frei J, Mahler F. Acute and long-term effects of prostaglandin E1 assessed by clinical and microcirculatory parameters in critical limb ischemia: a pilot study. Int J Microcirc Clin Exp. 1996 Mar-Apr; 16(2):57-63.
    View in: PubMed
  96. Ong F, Kaiser U, Seelen PJ, Hermans J, Wijermans PW, de Kieviet W, Jaques G, Kluin-Nelemans JC. Serum neural cell adhesion molecule differentiates multiple myeloma from paraproteinemias due to other causes. Blood. 1996 Jan 15; 87(2):712-6.
    View in: PubMed
  97. Kaiser UB, Sabbagh E, Katzenellenbogen RA, Conn PM, Chin WW. A mechanism for the differential regulation of gonadotropin subunit gene expression by gonadotropin-releasing hormone. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12280-4.
    View in: PubMed
  98. Soufi M, Kaiser U, Schneider A, Beato M, Westphal HM. The DNA and steroid binding domains of the glucocorticoid receptor are not altered in mononuclear cells of treated CLL patients. Exp Clin Endocrinol Diabetes. 1995; 103(3):175-83.
    View in: PubMed
  99. Kaiser UB, Sabbagh E, Katzenellenbogen RA, Conn PM, Chin WW. A mechanism for the differential regulation of gonadoropins by gonadotropin-releasing hormone. Proc Natl Acad Science USA. 1995; 92:12280-4.
  100. Albarracin CT, Kaiser UB, Chin WW. Isolation and characterization of the 5'-flanking region of the mouse gonadotropin-releasing hormone receptor gene. Endocrinology. 1994 Dec; 135(6):2300-6.
    View in: PubMed
  101. Stanislaus D, Janovick JA, Jennes L, Kaiser UB, Chin WW, Conn PM. Functional and morphological characterization of four cell lines derived from GH3 cells stably transfected with gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid. Endocrinology. 1994 Nov; 135(5):2220-7.
    View in: PubMed
  102. Kaiser UB, Katzenellenbogen RA, Conn PM, Chin WW. Evidence that signalling pathways by which thyrotropin-releasing hormone and gonadotropin-releasing hormone act are both common and distinct. Mol Endocrinol. 1994 Aug; 8(8):1038-48.
    View in: PubMed
  103. Kuphal D, Janovick JA, Kaiser UB, Chin WW, Conn PM. Stable transfection of GH3 cells with rat gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid results in expression of a receptor coupled to cyclic adenosine 3',5'-monophosphate-dependent prolactin release via a G-protein. Endocrinology. 1994 Jul; 135(1):315-20.
    View in: PubMed
  104. Kaiser UB, Dushkin H, Altherr MR, Beier DR, Chin WW. Chromosomal localization of the gonadotropin-releasing hormone receptor gene to human chromosome 4q13.1-q21.1 and mouse chromosome 5. Genomics. 1994 Apr; 20(3):506-8.
    View in: PubMed
  105. Kuphal D, Janovick J, Kaiser UB, Chin WW, Conn PM. Stable transfection of GH3 cells with rat GnRH receptor cDNA results in expression of a receptor which is coupled to cyclic AMP-dependent prolactin release via a G protein. Endocrinology. 1994; 135:315-20.
  106. Kaiser UB, Jakubowiak A, Steinberger A, Chin WW. Regulation of rat pituitary gonadotropin-releasing hormone receptor mRNA levels in vivo and in vitro. Endocrinology. 1993 Aug; 133(2):931-4.
    View in: PubMed
  107. Kaiser UB, Chin WW. Regulation of follistatin messenger ribonucleic acid levels in the rat pituitary. J Clin Invest. 1993 Jun; 91(6):2523-31.
    View in: PubMed
  108. Kaiser UB, Zhao D, Cardona GR, Chin WW. Isolation and characterization of cDNAs encoding the rat pituitary gonadotropin-releasing hormone receptor. Biochem Biophys Res Commun. 1992 Dec 30; 189(3):1645-52.
    View in: PubMed
  109. Kaiser UB, Lee BL, Carroll RS, Unabia G, Chin WW, Childs GV. Follistatin gene expression in the pituitary: localization in gonadotropes and folliculostellate cells in diestrous rats. Endocrinology. 1992 May; 130(5):3048-56.
    View in: PubMed
  110. Kaiser UB, Ethier JH, Kamel KS, Halperin ML. Persistent hyperkalemia in a patient with diabetes mellitus: a reversible defect in kaliuresis during bicarbonaturia. Clin Invest Med. 1992 Apr; 15(2):187-93.
    View in: PubMed
  111. Jaques G, Kiefer P, Schöneberger HJ, Wegmann B, Kaiser U, Brandscheid D, Havemann K. Differential expression of insulin-like growth factor binding proteins in human non-small cell lung cancer cell lines. Eur J Cancer. 1992; 28A(11):1899-904.
    View in: PubMed
  112. Kaiser UB, Ethier JH, Kamel KS, Halperin ML. Presistent hyperkalemia in a patient with diabetes mellitus:; Presumptive evidence for a chloride shunt type of disorder. Clin Invest Med. 1992; 15:187-93.
  113. Kaiser UB, Hegele RA. Case report: heterogeneity of aldolase B in hereditary fructose intolerance. Am J Med Sci. 1991 Dec; 302(6):364-8.
    View in: PubMed
  114. Carlisle EJ, Donnelly SM, Ethier JH, Quaggin SE, Kaiser UB, Vasuvattakul S, Kamel KS, Halperin ML. Modulation of the secretion of potassium by accompanying anions in humans. Kidney Int. 1991 Jun; 39(6):1206-12.
    View in: PubMed
  115. Sauerbrei A, Wutzler P, Pfister W, Kaiser U, Schreiber D, Rüdiger KD. [Microbiological and morphological findings in reactive lymphadenopathy]. Zentralbl Allg Pathol. 1990; 136(5):419-25.
    View in: PubMed
  116. Albrecht S, Gardiner GW, Kovacs K, Ilse G, Kaiser U. Duodenal somatostatinoma with psammoma bodies. Arch Pathol Lab Med. 1989 May; 113(5):517-20.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Kaiser's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_