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Last Name
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Jay Steven Loeffler, M.D.

TitleHerman and Joan Suit Professor of Radiation Oncology
InstitutionMassachusetts General Hospital
DepartmentRadiation Oncology
AddressMassachusetts General Hospital
Dept of Radiation Oncology
100 Blossom Street
Boston MA 02114
Phone617/724-1548
Fax617/726-3603
Other Positions
TitleHead of the Department of Radiation Oncology At the Massachusetts General Hospital
InstitutionMassachusetts General Hospital
DepartmentRadiation Oncology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lin E, Wexler TL, Nachtigall L, Tritos N, Swearingen B, Hemphill L, Loeffler J, Biller BM, Klibanski A, Miller KK. Effects of growth hormone deficiency on body composition and biomarkers of cardiovascular risk after definitive therapy for acromegaly. Clin Endocrinol (Oxf). 2012 Sep; 77(3):430-8.
    View in: PubMed
  2. Dennis ER, Bussiere MR, Niemierko A, Lu MW, Fullerton BC, Loeffler JS, Shih HA. A Comparison of Critical Structure Dose and Toxicity Risks in Patients with Low Grade Gliomas Treated with IMRT versus Proton Radiation Therapy. Technol Cancer Res Treat. 2013 Feb; 12(1):1-9.
    View in: PubMed
  3. Chan AW, Bernstein KD, Adams JA, Parambi RJ, Loeffler JS. Dose escalation with proton radiation therapy for high-grade meningiomas. Technol Cancer Res Treat. 2012 Dec; 11(6):607-14.
    View in: PubMed
  4. Arvold ND, Niemierko A, Broussard GP, Adams J, Fullerton B, Loeffler JS, Shih HA. Projected second tumor risk and dose to neurocognitive structures after proton versus photon radiotherapy for benign meningioma. Int J Radiat Oncol Biol Phys. 2012 Jul 15; 83(4):e495-500.
    View in: PubMed
  5. Hattangadi JA, Chapman PH, Bussière MR, Niemierko A, Ogilvy CS, Rowell A, Daartz J, Loeffler JS, Shih HA. Planned two-fraction proton beam stereotactic radiosurgery for high-risk inoperable cerebral arteriovenous malformations. Int J Radiat Oncol Biol Phys. 2012 Jun 1; 83(2):533-41.
    View in: PubMed
  6. Winkfield KM, Niemierko A, Bussiere MR, Crowley EM, Napolitano BN, Beaudette KP, Loeffler JS, Shih HA. Modeling intracranial second tumor risk and estimates of clinical toxicity with various radiation therapy techniques for patients with pituitary adenoma. Technol Cancer Res Treat. 2011 Jun; 10(3):243-51.
    View in: PubMed
  7. Son CH, Jimenez R, Niemierko A, Loeffler JS, Oh KS, Shih HA. Outcomes after whole brain reirradiation in patients with brain metastases. Int J Radiat Oncol Biol Phys. 2012 Feb 1; 82(2):e167-72.
    View in: PubMed
  8. Loeffler JS, Shih HA. Radiation therapy in the management of pituitary adenomas. J Clin Endocrinol Metab. 2011 Jul; 96(7):1992-2003.
    View in: PubMed
  9. Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK. The biology of brain metastases-translation to new therapies. Nat Rev Clin Oncol. 2011 Jun; 8(6):344-56.
    View in: PubMed
  10. Brem SS, Bierman PJ, Brem H, Butowski N, Chamberlain MC, Chiocca EA, DeAngelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hesser D, Junck L, Linette GP, Loeffler JS, Maor MH, Michael M, Moots PL, Morrison T, Mrugala M, Nabors LB, Newton HB, Portnow J, Raizer JJ, Recht L, Shrieve DC, Sills AK, Vrionis FD, Wen PY. Central nervous system cancers. J Natl Compr Canc Netw. 2011 Apr; 9(4):352-400.
    View in: PubMed
  11. Bassig BA, Inskip PD, Burdette L, Shapiro WR, Selker RG, Fine HA, Loeffler JS, Black PM, Dubrow R, Brenner AV. Selected human leukocyte antigen class II polymorphisms and risk of adult glioma. J Neuroimmunol. 2011 Apr; 233(1-2):185-91.
    View in: PubMed
  12. Kahn J, Loeffler JS, Niemierko A, Chiocca EA, Batchelor T, Chakravarti A. Long-term outcomes of patients with spinal cord gliomas treated by modern conformal radiation techniques. Int J Radiat Oncol Biol Phys. 2011 Sep 1; 81(1):232-8.
    View in: PubMed
  13. Halasz LM, Bussière MR, Dennis ER, Niemierko A, Chapman PH, Loeffler JS, Shih HA. Proton stereotactic radiosurgery for the treatment of benign meningiomas. Int J Radiat Oncol Biol Phys. 2011 Dec 1; 81(5):1428-35.
    View in: PubMed
  14. Plotkin SR, Halpin C, McKenna MJ, Loeffler JS, Batchelor TT, Barker FG. Erlotinib for progressive vestibular schwannoma in neurofibromatosis 2 patients. Otol Neurotol. 2010 Sep; 31(7):1135-43.
    View in: PubMed
  15. Hebart H, Lengerke C, Ljungman P, Paya CV, Klingebiel T, Loeffler J, Pfaffenrath S, Lewensohn-Fuchs I, Barkholt L, Tomiuk J, Meisner C, Lunenberg J, Top B, Razonable RR, Patel R, Litzow MR, Jahn G, Einsele H. Prospective comparison of PCR-based vs late mRNA-based preemptive antiviral therapy for HCMV infection in patients after allo-SCT. Bone Marrow Transplant. 2011 Mar; 46(3):408-15.
    View in: PubMed
  16. Batchelor TT, Duda DG, di Tomaso E, Ancukiewicz M, Plotkin SR, Gerstner E, Eichler AF, Drappatz J, Hochberg FH, Benner T, Louis DN, Cohen KS, Chea H, Exarhopoulos A, Loeffler JS, Moses MA, Ivy P, Sorensen AG, Wen PY, Jain RK. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol. 2010 Jun 10; 28(17):2817-23.
    View in: PubMed
  17. Miller KK, Wexler T, Fazeli P, Gunnell L, Graham GJ, Beauregard C, Hemphill L, Nachtigall L, Loeffler J, Swearingen B, Biller BM, Klibanski A. Growth hormone deficiency after treatment of acromegaly: a randomized, placebo-controlled study of growth hormone replacement. J Clin Endocrinol Metab. 2010 Feb; 95(2):567-77.
    View in: PubMed
  18. Merchant TE, Pollack IF, Loeffler JS. Brain tumors across the age spectrum: biology, therapy, and late effects. Semin Radiat Oncol. 2010 Jan; 20(1):58-66.
    View in: PubMed
  19. Rajaraman P, Hutchinson A, Wichner S, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Rothman N, Linet MS, Inskip PD. DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma. Neuro Oncol. 2010 Jan; 12(1):37-48.
    View in: PubMed
  20. Linskey ME, Andrews DW, Asher AL, Burri SH, Kondziolka D, Robinson PD, Ammirati M, Cobbs CS, Gaspar LE, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Kalkanis SN. The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):45-68.
    View in: PubMed
  21. Gaspar LE, Mehta MP, Patchell RA, Burri SH, Robinson PD, Morris RE, Ammirati M, Andrews DW, Asher AL, Cobbs CS, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Mikkelsen T, Olson JJ, Paleologos NA, Ryken TC, Kalkanis SN. The role of whole brain radiation therapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):17-32.
    View in: PubMed
  22. Mehta MP, Paleologos NA, Mikkelsen T, Robinson PD, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Gaspar LE, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Olson JJ, Patchell RA, Ryken TC, Kalkanis SN. The role of chemotherapy in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):71-83.
    View in: PubMed
  23. Kalkanis SN, Kondziolka D, Gaspar LE, Burri SH, Asher AL, Cobbs CS, Ammirati M, Robinson PD, Andrews DW, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Ryken TC, Linskey ME. The role of surgical resection in the management of newly diagnosed brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):33-43.
    View in: PubMed
  24. Ammirati M, Cobbs CS, Linskey ME, Paleologos NA, Ryken TC, Burri SH, Asher AL, Loeffler JS, Robinson PD, Andrews DW, Gaspar LE, Kondziolka D, McDermott M, Mehta MP, Mikkelsen T, Olson JJ, Patchell RA, Kalkanis SN. The role of retreatment in the management of recurrent/progressive brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):85-96.
    View in: PubMed
  25. Olson JJ, Paleologos NA, Gaspar LE, Robinson PD, Morris RE, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Mehta MP, Mikkelsen T, Patchell RA, Ryken TC, Kalkanis SN. The role of emerging and investigational therapies for metastatic brain tumors: a systematic review and evidence-based clinical practice guideline of selected topics. J Neurooncol. 2010 Jan; 96(1):115-42.
    View in: PubMed
  26. Mikkelsen T, Paleologos NA, Robinson PD, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Gaspar LE, Kondziolka D, Linskey ME, Loeffler JS, McDermott M, Mehta MP, Olson JJ, Patchell RA, Ryken TC, Kalkanis SN. The role of prophylactic anticonvulsants in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):97-102.
    View in: PubMed
  27. Ryken TC, McDermott M, Robinson PD, Ammirati M, Andrews DW, Asher AL, Burri SH, Cobbs CS, Gaspar LE, Kondziolka D, Linskey ME, Loeffler JS, Mehta MP, Mikkelsen T, Olson JJ, Paleologos NA, Patchell RA, Kalkanis SN. The role of steroids in the management of brain metastases: a systematic review and evidence-based clinical practice guideline. J Neurooncol. 2010 Jan; 96(1):103-14.
    View in: PubMed
  28. Durante M, Loeffler JS. Charged particles in radiation oncology. Nat Rev Clin Oncol. 2010 Jan; 7(1):37-43.
    View in: PubMed
  29. Truong MT, Kamat UR, Liebsch NJ, Curry WT, Lin DT, Barker FG, Loeffler JS, Chan AW. Proton radiation therapy for primary sphenoid sinus malignancies: treatment outcome and prognostic factors. Head Neck. 2009 Oct; 31(10):1297-308.
    View in: PubMed
  30. Gabeau-Lacet D, Engler D, Gupta S, Scangas GA, Betensky RA, Barker FG, Loeffler JS, Louis DN, Mohapatra G. Genomic profiling of atypical meningiomas associates gain of 1q with poor clinical outcome. J Neuropathol Exp Neurol. 2009 Oct; 68(10):1155-65.
    View in: PubMed
  31. Gabeau-Lacet D, Aghi M, Betensky RA, Barker FG, Loeffler JS, Louis DN. Bone involvement predicts poor outcome in atypical meningioma. J Neurosurg. 2009 Sep; 111(3):464-71.
    View in: PubMed
  32. Noda SE, Lautenschlaeger T, Siedow MR, Patel DR, El-Jawahri A, Suzuki Y, Loeffler JS, Bussiere MR, Chakravarti A. Technological advances in radiation oncology for central nervous system tumors. Semin Radiat Oncol. 2009 Jul; 19(3):179-86.
    View in: PubMed
  33. Jain RK, Duda DG, Willett CG, Sahani DV, Zhu AX, Loeffler JS, Batchelor TT, Sorensen AG. Biomarkers of response and resistance to antiangiogenic therapy. Nat Rev Clin Oncol. 2009 Jun; 6(6):327-38.
    View in: PubMed
  34. Podoloff DA, Ball DW, Ben-Josef E, Benson AB, Cohen SJ, Coleman RE, Delbeke D, Ho M, Ilson DH, Kalemkerian GP, Lee RJ, Loeffler JS, Macapinlac HA, Morgan RJ, Siegel BA, Singhal S, Tyler DS, Wong RJ. NCCN task force: clinical utility of PET in a variety of tumor types. J Natl Compr Canc Netw. 2009 Jun; 7 Suppl 2:S1-26.
    View in: PubMed
  35. Plotkin SR, Halpin C, Blakeley JO, Slattery WH, Welling DB, Chang SM, Loeffler JS, Harris GJ, Sorensen AG, McKenna MJ, Barker FG. Suggested response criteria for phase II antitumor drug studies for neurofibromatosis type 2 related vestibular schwannoma. J Neurooncol. 2009 May; 93(1):61-77.
    View in: PubMed
  36. Arvold ND, Lessell S, Bussiere M, Beaudette K, Rizzo JF, Loeffler JS, Shih HA. Visual outcome and tumor control after conformal radiotherapy for patients with optic nerve sheath meningioma. Int J Radiat Oncol Biol Phys. 2009 Nov 15; 75(4):1166-72.
    View in: PubMed
  37. Wexler T, Gunnell L, Omer Z, Kuhlthau K, Beauregard C, Graham G, Utz AL, Biller B, Nachtigall L, Loeffler J, Swearingen B, Klibanski A, Miller KK. Growth hormone deficiency is associated with decreased quality of life in patients with prior acromegaly. J Clin Endocrinol Metab. 2009 Jul; 94(7):2471-7.
    View in: PubMed
  38. Gerstner ER, Duda DG, di Tomaso E, Ryg PA, Loeffler JS, Sorensen AG, Ivy P, Jain RK, Batchelor TT. VEGF inhibitors in the treatment of cerebral edema in patients with brain cancer. Nat Rev Clin Oncol. 2009 Apr; 6(4):229-36.
    View in: PubMed
  39. Coble JB, Dosemeci M, Stewart PA, Blair A, Bowman J, Fine HA, Shapiro WR, Selker RG, Loeffler JS, Black PM, Linet MS, Inskip PD. Occupational exposure to magnetic fields and the risk of brain tumors. Neuro Oncol. 2009 Jun; 11(3):242-9.
    View in: PubMed
  40. Shih HA, Loeffler JS, Tarbell NJ. Late effects of CNS radiation therapy. Cancer Treat Res. 2009; 150:23-41.
    View in: PubMed
  41. Hebart H, Klingspor L, Klingebiel T, Loeffler J, Tollemar J, Ljungman P, Wandt H, Schaefer-Eckart K, Dornbusch HJ, Meisner C, Engel C, Stenger N, Mayer T, Ringden O, Einsele H. A prospective randomized controlled trial comparing PCR-based and empirical treatment with liposomal amphotericin B in patients after allo-SCT. Bone Marrow Transplant. 2009 Apr; 43(7):553-61.
    View in: PubMed
  42. Smith ER, Loeffler J, Misra M, Pomerantz SR, Stemmer-Rachamimov A, Post MD. Case records of the Massachusetts General Hospital. Case 37-2008. A 17-year-old boy with a pituitary tumor and skull abnormalities. N Engl J Med. 2008 Nov 27; 359(22):2367-77.
    View in: PubMed
  43. Loeffler JS, Halperin EC. Selling a medical school's name: ethical and practical dilemmas. JAMA. 2008 Oct 22; 300(16):1937-8.
    View in: PubMed
  44. Swearingen B, Loeffler J. Does radiosurgery have a role in the treatment of acromegaly? Nat Clin Pract Endocrinol Metab. 2008 Nov; 4(11):592-3.
    View in: PubMed
  45. Rajaraman P, Hutchinson A, Rothman N, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Linet MS, Inskip PD. Oxidative response gene polymorphisms and risk of adult brain tumors. Neuro Oncol. 2008 Oct; 10(5):709-15.
    View in: PubMed
  46. Lönn S, Rothman N, Shapiro WR, Fine HA, Selker RG, Black PM, Loeffler JS, Hutchinson AA, Inskip PD. Genetic variation in insulin-like growth factors and brain tumor risk. Neuro Oncol. 2008 Aug; 10(4):553-9.
    View in: PubMed
  47. Loeffler JS. Technology assessment in radiation oncology: time for reassessment? Nat Clin Pract Oncol. 2008 Jun; 5(6):299.
    View in: PubMed
  48. Drzymala RE, Wasserman TH, Won M, Shaw E, Cmelak AJ, Loeffler J, Souhami L. A phase I-B trial of the radiosensitizer: etanidazole (SR-2508) with radiosurgery for the treatment of recurrent previously irradiated primary brain tumors or brain metastases (RTOG Study 95-02). Radiother Oncol. 2008 Apr; 87(1):89-92.
    View in: PubMed
  49. Shih HA, Loeffler JS. Radiation therapy in acromegaly. Rev Endocr Metab Disord. 2008 Mar; 9(1):59-65.
    View in: PubMed
  50. Sher DJ, Henson JW, Avutu B, Hochberg FH, Batchelor TT, Martuza RL, Barker FG, Loeffler JS, Chakravarti A. The added value of concurrently administered temozolomide versus adjuvant temozolomide alone in newly diagnosed glioblastoma. J Neurooncol. 2008 May; 88(1):43-50.
    View in: PubMed
  51. Suit H, Kooy H, Trofimov A, Farr J, Munzenrider J, DeLaney T, Loeffler J, Clasie B, Safai S, Paganetti H. Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No. Radiother Oncol. 2008 Feb; 86(2):148-53.
    View in: PubMed
  52. Aghi MK, Petit J, Chapman P, Loeffler J, Klibanski A, Biller BM, Swearingen B. Management of recurrent and refractory Cushing's disease with reoperation and/or proton beam radiosurgery. Clin Neurosurg. 2008; 55:141-4.
    View in: PubMed
  53. Petit JH, Biller BM, Yock TI, Swearingen B, Coen JJ, Chapman P, Ancukiewicz M, Bussiere M, Klibanski A, Loeffler JS. Proton stereotactic radiotherapy for persistent adrenocorticotropin-producing adenomas. J Clin Endocrinol Metab. 2008 Feb; 93(2):393-9.
    View in: PubMed
  54. Petit JH, Biller BM, Coen JJ, Swearingen B, Ancukiewicz M, Bussiere M, Chapman P, Klibanski A, Loeffler JS. Proton stereotactic radiosurgery in management of persistent acromegaly. Endocr Pract. 2007 Nov-Dec; 13(7):726-34.
    View in: PubMed
  55. Rajaraman P, Wang SS, Rothman N, Brown MM, Black PM, Fine HA, Loeffler JS, Selker RG, Shapiro WR, Chanock SJ, Inskip PD. Polymorphisms in apoptosis and cell cycle control genes and risk of brain tumors in adults. Cancer Epidemiol Biomarkers Prev. 2007 Aug; 16(8):1655-61.
    View in: PubMed
  56. Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT. Angiogenesis in brain tumours. Nat Rev Neurosci. 2007 Aug; 8(8):610-22.
    View in: PubMed
  57. Parodi K, Paganetti H, Shih HA, Michaud S, Loeffler JS, DeLaney TF, Liebsch NJ, Munzenrider JE, Fischman AJ, Knopf A, Bortfeld T. Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy. Int J Radiat Oncol Biol Phys. 2007 Jul 1; 68(3):920-34.
    View in: PubMed
  58. Eichler AF, Loeffler JS. Multidisciplinary management of brain metastases. Oncologist. 2007 Jul; 12(7):884-98.
    View in: PubMed
  59. Chakravarti A, Tyndall E, Palanichamy K, Mehta M, Aldape K, Loeffler J. Impact of molecular profiling on clinical trial design for glioblastoma. Curr Oncol Rep. 2007 Jan; 9(1):71-9.
    View in: PubMed
  60. Elia AE, Shih HA, Loeffler JS. Stereotactic radiation treatment for benign meningiomas. Neurosurg Focus. 2007; 23(4):E5.
    View in: PubMed
  61. Chen CC, Chapman P, Petit J, Loeffler J. Proton radiosurgery in neurosurgery. Neurosurg Focus. 2007; 23(6):E5.
    View in: PubMed
  62. Batchelor TT, Sorensen AG, di Tomaso E, Zhang WT, Duda DG, Cohen KS, Kozak KR, Cahill DP, Chen PJ, Zhu M, Ancukiewicz M, Mrugala MM, Plotkin S, Drappatz J, Louis DN, Ivy P, Scadden DT, Benner T, Loeffler JS, Wen PY, Jain RK. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients. Cancer Cell. 2007 Jan; 11(1):83-95.
    View in: PubMed
  63. Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB. Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma. J Soc Integr Oncol. 2007; 5(1):11-7.
    View in: PubMed
  64. Rajaraman P, Stewart PA, Samet JM, Schwartz BS, Linet MS, Zahm SH, Rothman N, Yeager M, Fine HA, Black PM, Loeffler J, Shapiro WR, Selker RG, Inskip PD. Lead, genetic susceptibility, and risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev. 2006 Dec; 15(12):2514-20.
    View in: PubMed
  65. Bluhm EC, Zahm SH, Fine HA, Black PM, Loeffler JS, Shapiro WR, Selker RG, Inskip PD. Personal hair dye use and risks of glioma, meningioma, and acoustic neuroma among adults. Am J Epidemiol. 2007 Jan 1; 165(1):63-71.
    View in: PubMed
  66. Patchell RA, Regine WF, Loeffler JS, Sawaya R, Andrews DW, Chin LS. Radiosurgery plus whole-brain radiation therapy for brain metastases. JAMA. 2006 Nov 1; 296(17):2089-90; author reply 2090-1.
    View in: PubMed
  67. Patchell RA, Regine WF, Renschler M, Loeffler JS, Sawaya R, Chin LS, Andrews DW. Comments about the prospective randomized trial by Aoyama et al. Surg Neurol. 2006 Nov; 66(5):459-60.
    View in: PubMed
  68. Pommier P, Liebsch NJ, Deschler DG, Lin DT, McIntyre JF, Barker FG, Adams JA, Lopes VV, Varvares M, Loeffler JS, Chan AW. Proton beam radiation therapy for skull base adenoid cystic carcinoma. Arch Otolaryngol Head Neck Surg. 2006 Nov; 132(11):1242-9.
    View in: PubMed
  69. Rabinov JD, Cheng LL, Lee PL, Brisman JL, Loeffler JS, Cole AJ, Cosgrove GR, Bussiere MR, Chaves T, Gonzalez RG. MR spectroscopic changes in the rat hippocampus following proton radiosurgery. Stereotact Funct Neurosurg. 2006; 84(4):147-54.
    View in: PubMed
  70. Chakravarti A, Erkkinen MG, Nestler U, Stupp R, Mehta M, Aldape K, Gilbert MR, Black PM, Loeffler JS. Temozolomide-mediated radiation enhancement in glioblastoma: a report on underlying mechanisms. Clin Cancer Res. 2006 Aug 1; 12(15):4738-46.
    View in: PubMed
  71. Lengerke C, Ljubicic T, Meisner C, Loeffler J, Sinzger C, Einsele H, Hebart H. Evaluation of the COBAS Amplicor HCMV Monitor for early detection and monitoring of human cytomegalovirus infection after allogeneic stem cell transplantation. Bone Marrow Transplant. 2006 Jul; 38(1):53-60.
    View in: PubMed
  72. Byrne TN, Borges LF, Loeffler JS. Metastatic epidural spinal cord compression: update on management. Semin Oncol. 2006 Jun; 33(3):307-11.
    View in: PubMed
  73. Verhey LJ, Chen CC, Chapman P, Loeffler J, Curry WT. Single-fraction stereotactic radiosurgery for intracranial targets. Neurosurg Clin N Am. 2006 Apr; 17(2):79-97, v.
    View in: PubMed
  74. Batchelor T, Loeffler JS. Primary CNS lymphoma. J Clin Oncol. 2006 Mar 10; 24(8):1281-8.
    View in: PubMed
  75. MacDonald SM, DeLaney TF, Loeffler JS. Proton beam radiation therapy. Cancer Invest. 2006 Mar; 24(2):199-208.
    View in: PubMed
  76. Miller KK, Biller BM, Beauregard C, Lipman JG, Jones J, Schoenfeld D, Sherman JC, Swearingen B, Loeffler J, Klibanski A. Effects of testosterone replacement in androgen-deficient women with hypopituitarism: a randomized, double-blind, placebo-controlled study. J Clin Endocrinol Metab. 2006 May; 91(5):1683-90.
    View in: PubMed
  77. Jain RK, Duda DG, Clark JW, Loeffler JS. Lessons from phase III clinical trials on anti-VEGF therapy for cancer. Nat Clin Pract Oncol. 2006 Jan; 3(1):24-40.
    View in: PubMed
  78. Barabino S, Raghavan A, Loeffler J, Dana R. Radiotherapy-induced ocular surface disease. Cornea. 2005 Nov; 24(8):909-14.
    View in: PubMed
  79. Loeffler JS, Nachtigall LB. Is fractionated stereotactic radiotherapy effective in pituitary adenomas? Nat Clin Pract Oncol. 2005 Nov; 2(11):548-9.
    View in: PubMed
  80. Levin WP, Kooy H, Loeffler JS, DeLaney TF. Proton beam therapy. Br J Cancer. 2005 Oct 17; 93(8):849-54.
    View in: PubMed
  81. Curry WT, Cosgrove GR, Hochberg FH, Loeffler J, Zervas NT. Stereotactic interstitial radiosurgery for cerebral metastases. J Neurosurg. 2005 Oct; 103(4):630-5.
    View in: PubMed
  82. Chan AW, Black P, Ojemann RG, Barker FG, Kooy HM, Lopes VV, McKenna MJ, Shrieve DC, Martuza RL, Loeffler JS. Stereotactic radiotherapy for vestibular schwannomas: favorable outcome with minimal toxicity. Neurosurgery. 2005 Jul; 57(1):60-70; discussion 60-70.
    View in: PubMed
  83. Shih HA, Betensky RA, Dorfman MV, Louis DN, Loeffler JS, Batchelor TT. Genetic analyses for predictors of radiation response in glioblastoma. Int J Radiat Oncol Biol Phys. 2005 Nov 1; 63(3):704-10.
    View in: PubMed
  84. Kirsch DG, Loeffler JS. Brain metastases in patients with breast cancer: new horizons. Clin Breast Cancer. 2005 Jun; 6(2):115-24.
    View in: PubMed
  85. Sheehan JP, Niranjan A, Sheehan JM, Jane JA, Laws ER, Kondziolka D, Flickinger J, Landolt AM, Loeffler JS, Lunsford LD. Stereotactic radiosurgery for pituitary adenomas: an intermediate review of its safety, efficacy, and role in the neurosurgical treatment armamentarium. J Neurosurg. 2005 Apr; 102(4):678-91.
    View in: PubMed
  86. Kirsch DG, Ledezma CJ, Mathews CS, Bhan AK, Ancukiewicz M, Hochberg FH, Loeffler JS. Survival after brain metastases from breast cancer in the trastuzumab era. J Clin Oncol. 2005 Mar 20; 23(9):2114-6; author reply 2116-7.
    View in: PubMed
  87. Nguyen PL, Chakravarti A, Finkelstein DM, Hochberg FH, Batchelor TT, Loeffler JS. Results of whole-brain radiation as salvage of methotrexate failure for immunocompetent patients with primary CNS lymphoma. J Clin Oncol. 2005 Mar 1; 23(7):1507-13.
    View in: PubMed
  88. Plotkin SR, Dorfman MV, Loeffler JS. Facial numbness in a man with inguinal and retroperitoneal masses. Nat Clin Pract Oncol. 2005 Jan; 2(1):54-8; quiz 1 p following 58.
    View in: PubMed
  89. Kirsch DG, Loeffler JS. Treating brain metastases: current approaches and future directions. Expert Rev Neurother. 2004 Nov; 4(6):1015-22.
    View in: PubMed
  90. Lawenda BD, Gagne HM, Gierga DP, Niemierko A, Wong WM, Tarbell NJ, Chen GT, Hochberg FH, Loeffler JS. Permanent alopecia after cranial irradiation: dose-response relationship. Int J Radiat Oncol Biol Phys. 2004 Nov 1; 60(3):879-87.
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  92. Eskandar EN, Loeffler JS, O'Neill AM, Hunter GJ, Louis DN. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 33-2004. A 34-year-old man with a seizure and a frontal-lobe brain lesion. N Engl J Med. 2004 Oct 28; 351(18):1875-82.
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  93. Rabinov JD, Brisman JL, Cole AJ, Lee PL, Bussiere MR, Chapman PH, Loeffler JS, Cosgrove GR, Chaves T, Gonzalez RG. MRI changes in the rat hippocampus following proton radiosurgery. Stereotact Funct Neurosurg. 2004; 82(4):156-64.
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  94. Kondziolka D, Lunsford LD, Loeffler JS, Friedman WA. Radiosurgery and radiotherapy: observations and clarifications. J Neurosurg. 2004 Oct; 101(4):585-9.
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  95. Chakravarti A, Zhai GG, Zhang M, Malhotra R, Latham DE, Delaney MA, Robe P, Nestler U, Song Q, Loeffler J. Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms. Oncogene. 2004 Sep 30; 23(45):7494-506.
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  96. Chapman PH, Ogilvy CS, Loeffler JS. The relationship between occlusive hyperemia and complications associated with the radiosurgical treatment of arteriovenous malformations: report of two cases. Neurosurgery. 2004 Jul; 55(1):228-33; discussion 233-4.
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  97. Chakravarti A, Zhai G, Suzuki Y, Sarkesh S, Black PM, Muzikansky A, Loeffler JS. The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. J Clin Oncol. 2004 May 15; 22(10):1926-33.
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  98. St Clair WH, Adams JA, Bues M, Fullerton BC, La Shell S, Kooy HM, Loeffler JS, Tarbell NJ. Advantage of protons compared to conventional X-ray or IMRT in the treatment of a pediatric patient with medulloblastoma. Int J Radiat Oncol Biol Phys. 2004 Mar 1; 58(3):727-34.
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  99. Weber DC, Chan AW, Bussiere MR, Harsh GR, Ancukiewicz M, Barker FG, Thornton AT, Martuza RL, Nadol JB, Chapman PH, Loeffler JS. Proton beam radiosurgery for vestibular schwannoma: tumor control and cranial nerve toxicity. Neurosurgery. 2003 Sep; 53(3):577-86; discussion 586-8.
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  100. Barker FG, Butler WE, Lyons S, Cascio E, Ogilvy CS, Loeffler JS, Chapman PH. Dose-volume prediction of radiation-related complications after proton beam radiosurgery for cerebral arteriovenous malformations. J Neurosurg. 2003 Aug; 99(2):254-63.
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  101. Loeffler JS, Niemierko A, Chapman PH. Second tumors after radiosurgery: tip of the iceberg or a bump in the road? Neurosurgery. 2003 Jun; 52(6):1436-40; discussion 1440-2.
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  102. Inskip PD, Tarone RE, Hatch EE, Wilcosky TC, Fine HA, Black PM, Loeffler JS, Shapiro WR, Selker RG, Linet MS. Sociodemographic indicators and risk of brain tumours. Int J Epidemiol. 2003 Apr; 32(2):225-33.
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  103. Inskip PD, Tarone RE, Hatch EE, Wilcosky TC, Selker RG, Fine HA, Black PM, Loeffler JS, Shapiro WR, Linet MS. Laterality of brain tumors. Neuroepidemiology. 2003 Mar-Apr; 22(2):130-8.
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  104. Suit H, Goldberg S, Niemierko A, Trofimov A, Adams J, Paganetti H, Chen GT, Bortfeld T, Rosenthal S, Loeffler J, Delaney T. Proton beams to replace photon beams in radical dose treatments. Acta Oncol. 2003; 42(8):800-8.
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  105. Rabinov JD, Lee PL, Barker FG, Louis DN, Harsh GR, Cosgrove GR, Chiocca EA, Thornton AF, Loeffler JS, Henson JW, Gonzalez RG. In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience. Radiology. 2002 Dec; 225(3):871-9.
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  106. Harsh GR, Thornton AF, Chapman PH, Bussiere MR, Rabinov JD, Loeffler JS. Proton beam stereotactic radiosurgery of vestibular schwannomas. Int J Radiat Oncol Biol Phys. 2002 Sep 1; 54(1):35-44.
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  107. Hoh BL, Chapman PH, Loeffler JS, Carter BS, Ogilvy CS. Results of multimodality treatment for 141 patients with brain arteriovenous malformations and seizures: factors associated with seizure incidence and seizure outcomes. Neurosurgery. 2002 Aug; 51(2):303-9; discussion 309-11.
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  108. Chakravarti A, Chakladar A, Delaney MA, Latham DE, Loeffler JS. The epidermal growth factor receptor pathway mediates resistance to sequential administration of radiation and chemotherapy in primary human glioblastoma cells in a RAS-dependent manner. Cancer Res. 2002 Aug 1; 62(15):4307-15.
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  109. Hebart H, Rudolph T, Loeffler J, Middeldorp J, Ljubicic T, Jahn G, Einsele H. Evaluation of the NucliSens CMV pp67 assay for detection and monitoring of human cytomegalovirus infection after allogeneic stem cell transplantation. Bone Marrow Transplant. 2002 Aug; 30(3):181-7.
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  110. Jeter MD, Jänne PA, Brooks S, Burstein HJ, Wen P, Fuchs CS, Loeffler JS, Devlin PM, Salgia R. Gemcitabine-induced radiation recall. Int J Radiat Oncol Biol Phys. 2002 Jun 1; 53(2):394-400.
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  111. Paganetti H, Niemierko A, Ancukiewicz M, Gerweck LE, Goitein M, Loeffler JS, Suit HD. Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat Oncol Biol Phys. 2002 Jun 1; 53(2):407-21.
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  112. Chakravarti A, Noll E, Black PM, Finkelstein DF, Finkelstein DM, Dyson NJ, Loeffler JS. Quantitatively determined survivin expression levels are of prognostic value in human gliomas. J Clin Oncol. 2002 Feb 15; 20(4):1063-8.
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  113. Chakravarti A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res. 2002 Jan 1; 62(1):200-7.
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  114. Chon BH, Loeffler JS. The effect of nonmalignant systemic disease on tolerance to radiation therapy. Oncologist. 2002; 7(2):136-43.
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  116. Chakravarti A, Delaney MA, Noll E, Black PM, Loeffler JS, Muzikansky A, Dyson NJ. Prognostic and pathologic significance of quantitative protein expression profiling in human gliomas. Clin Cancer Res. 2001 Aug; 7(8):2387-95.
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  117. Hodgson DC, Goumnerova LC, Loeffler JS, Dutton S, Black PM, Alexander E, Xu R, Kooy H, Silver B, Tarbell NJ. Radiosurgery in the management of pediatric brain tumors. Int J Radiat Oncol Biol Phys. 2001 Jul 15; 50(4):929-35.
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  118. Pai HH, Thornton A, Katznelson L, Finkelstein DM, Adams JA, Fullerton BC, Loeffler JS, Leibsch NJ, Klibanski A, Munzenrider JE. Hypothalamic/pituitary function following high-dose conformal radiotherapy to the base of skull: demonstration of a dose-effect relationship using dose-volume histogram analysis. Int J Radiat Oncol Biol Phys. 2001 Mar 15; 49(4):1079-92.
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  119. Chan AW, Loeffler JS. Controversies in the management of patients with brain metastases. Cancer J. 2001 Mar-Apr; 7(2):105-7.
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  121. Black PM, Villavicencio AT, Rhouddou C, Loeffler JS. Aggressive surgery and focal radiation in the management of meningiomas of the skull base: preservation of function with maintenance of local control. Acta Neurochir (Wien). 2001; 143(6):555-62.
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  124. Park CC, Hartmann C, Folkerth R, Loeffler JS, Wen PY, Fine HA, Black PM, Shafman T, Louis DN. Systemic metastasis in glioblastoma may represent the emergence of neoplastic subclones. J Neuropathol Exp Neurol. 2000 Dec; 59(12):1044-50.
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  128. Simpson JR, Mendenhall WM, Schupak KD, Larson D, Bloomer WD, Buckley JA, Gaspar LE, Gibbs FA, Lewin AA, Loeffler JS, Malcolm AW, Schneider JF, Shaw EG, Wharam MD, Gutin PH, Rogers L, Leibel S. Follow-up and retreatment of brain metastasis. American College of Radiology. ACR Appropriateness Criteria. Radiology. 2000 Jun; 215 Suppl:1129-35.
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  132. Shaw E, Scott C, Souhami L, Dinapoli R, Kline R, Loeffler J, Farnan N. Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05. Int J Radiat Oncol Biol Phys. 2000 May 1; 47(2):291-8.
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  133. Fine HA, Figg WD, Jaeckle K, Wen PY, Kyritsis AP, Loeffler JS, Levin VA, Black PM, Kaplan R, Pluda JM, Yung WK. Phase II trial of the antiangiogenic agent thalidomide in patients with recurrent high-grade gliomas. J Clin Oncol. 2000 Feb; 18(4):708-15.
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  143. Alexander E, Loeffler JS. The role of radiosurgery for glial neoplasms. Neurosurg Clin N Am. 1999 Apr; 10(2):351-8.
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  144. Corn BW, Mehta MP, Buatti JM, Wolfson AH, Greven KM, Kim RY, Dunton CJ, Loeffler JS. Stereotactic Irradiation: potential new treatment method for brain metastases resulting from ovarian cancer. Am J Clin Oncol. 1999 Apr; 22(2):143-6.
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  145. Mamon HJ, Wen PY, Burns AC, Loeffler JS. Allergic skin reactions to anticonvulsant medications in patients receiving cranial radiation therapy. Epilepsia. 1999 Mar; 40(3):341-4.
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  149. Mitsumori M, Shrieve DC, Alexander E, Kaiser UB, Richardson GE, Black PM, Loeffler JS. Initial clinical results of LINAC-based stereotactic radiosurgery and stereotactic radiotherapy for pituitary adenomas. Int J Radiat Oncol Biol Phys. 1998 Oct 1; 42(3):573-80.
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  152. Hebart H, Gamer D, Loeffler J, Mueller C, Sinzger C, Jahn G, Bader P, Klingebiel T, Kanz L, Einsele H. Evaluation of Murex CMV DNA hybrid capture assay for detection and quantitation of cytomegalovirus infection in patients following allogeneic stem cell transplantation. J Clin Microbiol. 1998 May; 36(5):1333-7.
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  154. Alexander E, Loeffler JS. Radiosurgery for primary malignant brain tumors. Semin Surg Oncol. 1998 Jan-Feb; 14(1):43-52.
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  155. Chang EL, Loeffler JS, Riese NE, Wen PY, Alexander E, Black PM, Coleman CN. Survival results from a phase I study of etanidazole (SR2508) and radiotherapy in patients with malignant glioma. Int J Radiat Oncol Biol Phys. 1998 Jan 1; 40(1):65-70.
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  162. Fine HA, Wen PY, Robertson M, O'Neill A, Kowal J, Loeffler JS, Black PM. A phase I trial of a new recombinant human beta-interferon (BG9015) for the treatment of patients with recurrent gliomas. Clin Cancer Res. 1997 Mar; 3(3):381-7.
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  163. Hakim R, Loeffler JS, Anthony DC, Black PM. Gangliogliomas in adults. Cancer. 1997 Jan 1; 79(1):127-31.
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  164. Schulder M, Black PM, Alexander E, Loeffler JS. The influence of Harvey Cushing on neuroradiologic therapy. Radiology. 1996 Dec; 201(3):671-4.
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  165. Bakardjiev AI, Barnes PD, Goumnerova LC, Black PM, Scott RM, Pomeroy SL, Billett A, Loeffler JS, Tarbell NJ. Magnetic resonance imaging changes after stereotactic radiation therapy for childhood low grade astrocytoma. Cancer. 1996 Aug 15; 78(4):864-73.
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  179. Loeffler JS, Shrieve DC, Coleman CN. Chemoradiation and adjuvant chemotherapy for glioblastoma: why does so much therapy yield so little improvement in survival? Int J Radiat Oncol Biol Phys. 1995 Sep 30; 33(2):531-3.
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  183. Healey EA, Shamberger RC, Grier HE, Loeffler JS, Tarbell NJ. A 10-year experience of pediatric brachytherapy. Int J Radiat Oncol Biol Phys. 1995 May 15; 32(2):451-5.
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  186. Alexander E, Moriarty TM, Davis RB, Wen PY, Fine HA, Black PM, Kooy HM, Loeffler JS. Stereotactic radiosurgery for the definitive, noninvasive treatment of brain metastases. J Natl Cancer Inst. 1995 Jan 4; 87(1):34-40.
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  187. Wen PY, Loeffler JS. Advances in the diagnosis and management of pituitary tumors. Curr Opin Oncol. 1995 Jan; 7(1):56-62.
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  188. Patrice SJ, Tarbell NJ, Goumnerova LC, Shrieve DC, Black PM, Loeffler JS. Results of radiosurgery in the management of recurrent and residual medulloblastoma. Pediatr Neurosurg. 1995; 22(4):197-203.
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  198. Hughes-Davies L, Mannarino E, Alexander E, Kooy H, Loeffler JS. Technical modifications required to treat cervical chemodactomas with stereotactic radiosurgery. Surg Neurol. 1994 May; 41(5):418-20.
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  199. Leibel SA, Scott CB, Loeffler JS. Contemporary approaches to the treatment of malignant gliomas with radiation therapy. Semin Oncol. 1994 Apr; 21(2):198-219.
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  200. Kooy HM, van Herk M, Barnes PD, Alexander E, Dunbar SF, Tarbell NJ, Mulkern RV, Holupka EJ, Loeffler JS. Image fusion for stereotactic radiotherapy and radiosurgery treatment planning. Int J Radiat Oncol Biol Phys. 1994 Mar 30; 28(5):1229-34.
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  201. Larson DA, Bova F, Eisert D, Kline R, Loeffler J, Lutz W, Mehta M, Palta J, Schewe K, Schultz C, et al. Current radiosurgery practice: results of an ASTRO survey. Task Force on Stereotactic Radiosurgery, American Society for Therapeutic Radiology and Oncology. Int J Radiat Oncol Biol Phys. 1994 Jan 15; 28(2):523-6.
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  202. Shrieve DC, Tarbell NJ, Alexander E, Kooy HM, Black PM, Dunbar S, Loeffler JS. Stereotactic radiotherapy: a technique for dose optimization and escalation for intracranial tumors. Acta Neurochir Suppl. 1994; 62:118-23.
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  203. Flickinger JC, Loeffler JS, Larson DA. Stereotactic radiosurgery for intracranial malignancies. Oncology (Williston Park). 1994 Jan; 8(1):81-6; discussion 86, 94, 97-8.
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  204. Haregewoin A, Alexander E, Black PM, Loeffler JS. Autocrine regulation of the production of the gaseous messenger nitric oxide in a glioblastoma cell line. Exp Cell Res. 1994 Jan; 210(1):137-9.
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  205. Tishler RB, Loeffler JS, Lunsford LD, Duma C, Alexander E, Kooy HM, Flickinger JC. Tolerance of cranial nerves of the cavernous sinus to radiosurgery. Int J Radiat Oncol Biol Phys. 1993 Sep 30; 27(2):215-21.
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  206. Black PM, Tarbell NJ, Alexander E, Rockoff M, Zhan MS, Loeffler J. Stereotactic techniques in managing pediatric brain tumors. Childs Nerv Syst. 1993 Sep; 9(6):343-6; discussion 347.
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  207. Levin JM, Schiff D, Loeffler JS, Fine HA, Black PM, Wen PY. Complications of therapy for venous thromboembolic disease in patients with brain tumors. Neurology. 1993 Jun; 43(6):1111-4.
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  208. Kooy HM, Nedzi LA, Alexander E, Loeffler JS, Ledoux RJ. Dose-volume histogram computations for small intracranial volumes. Med Phys. 1993 May-Jun; 20(3):755-60.
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  209. Fine HA, Dear KB, Loeffler JS, Black PM, Canellos GP. Meta-analysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer. 1993 Apr 15; 71(8):2585-97.
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  210. Nedzi LA, Kooy HM, Alexander E, Svensson GK, Loeffler JS. Dynamic field shaping for stereotactic radiosurgery: a modeling study. Int J Radiat Oncol Biol Phys. 1993 Apr 2; 25(5):859-69.
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  211. Larson DA, Flickinger JC, Loeffler JS. The radiobiology of radiosurgery. Int J Radiat Oncol Biol Phys. 1993 Feb 15; 25(3):557-61.
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  212. Slivka A, Wen PY, Shea WM, Loeffler JS. Pneumocystis carinii pneumonia during steroid taper in patients with primary brain tumors. Am J Med. 1993 Feb; 94(2):216-9.
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  213. Loeffler JS, Alexander E. Radiosurgery in the definitive management of CNS malignancies. Front Radiat Ther Oncol. 1993; 27:227-44.
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  214. Alexander E, Loeffler JS, Schwartz RB, Johnson KA, Carvalho PA, Garada BM, Zimmerman RE, Holman BL. Thallium-201 technetium-99m HMPAO single-photon emission computed tomography (SPECT) imaging for guiding stereotactic craniotomies in heavily irradiated malignant glioma patients. Acta Neurochir (Wien). 1993; 122(3-4):215-7.
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  215. Carvalho PA, Schwartz RB, Alexander E, Garada BM, Zimmerman RE, Loeffler JS, Holman BL. Detection of recurrent gliomas with quantitative thallium-201/technetium-99m HMPAO single-photon emission computerized tomography. J Neurosurg. 1992 Oct; 77(4):565-70.
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  216. Loeffler JS, Alexander E, Shea WM, Wen PY, Fine HA, Kooy HM, Black PM. Radiosurgery as part of the initial management of patients with malignant gliomas. J Clin Oncol. 1992 Sep; 10(9):1379-85.
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  217. Wen PY, Blanchard KL, Block CC, Loeffler JS, Davis DG, Lacroix LA, Antin JH. Development of Lhermitte's sign after bone marrow transplantation. Cancer. 1992 May 1; 69(9):2262-6.
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  218. Hurwitz SJ, Coleman CN, Riese N, Loeffler JS, Alexander E, Buswell L, Neben TY, Shargel L, Kramer RA. Distribution of etanidazole into human brain tumors: implications for treating high grade gliomas. Int J Radiat Oncol Biol Phys. 1992; 22(3):573-6.
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  219. Coleman CN, Noll L, Riese N, Buswell L, Howes AE, Loeffler JS, Alexander E, Wen P, Harris JR, Kramer RA, et al. Final report of the phase I trial of continuous infusion etanidazole (SR 2508): a Radiation Therapy Oncology Group study. Int J Radiat Oncol Biol Phys. 1992; 22(3):577-80.
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  220. Alexander E, Loeffler JS. Radiosurgery for intracranial vascular malformations: techniques, results, and complications. Clin Neurosurg. 1992; 39:273-91.
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  221. Alexander E, Loeffler JS. Radiosurgery using a modified linear accelerator. Neurosurg Clin N Am. 1992 Jan; 3(1):167-90.
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  222. Loeffler JS, Larson DA. Subspecialization in radiation oncology: impact of stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 1992; 24(5):885-7.
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  223. Coia LR, Aaronson N, Linggood R, Loeffler J, Priestman TJ. A report of the consensus workshop panel on the treatment of brain metastases. Int J Radiat Oncol Biol Phys. 1992; 23(1):223-7.
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  224. Schwartz RB, Carvalho PA, Alexander E, Loeffler JS, Folkerth R, Holman BL. Radiation necrosis vs high-grade recurrent glioma: differentiation by using dual-isotope SPECT with 201TI and 99mTc-HMPAO. AJNR Am J Neuroradiol. 1991 Nov-Dec; 12(6):1187-92.
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  225. Tarbell NJ, Loeffler JS, Silver B, Lynch E, Lavally BL, Kupsky WJ, Scott RM, Sallan SE. The change in patterns of relapse in medulloblastoma. Cancer. 1991 Oct 1; 68(7):1600-4.
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  226. Holman BL, Zimmerman RE, Johnson KA, Carvalho PA, Schwartz RB, Loeffler JS, Alexander E, Pelizzari CA, Chen GT. Computer-assisted superimposition of magnetic resonance and high-resolution technetium-99m-HMPAO and thallium-201 SPECT images of the brain. J Nucl Med. 1991 Aug; 32(8):1478-84.
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  227. Nedzi LA, Kooy H, Alexander E, Gelman RS, Loeffler JS. Variables associated with the development of complications from radiosurgery of intracranial tumors. Int J Radiat Oncol Biol Phys. 1991 Aug; 21(3):591-9.
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  228. Kooy HM, Nedzi LA, Loeffler JS, Alexander E, Cheng CW, Mannarino EG, Holupka EJ, Siddon RL. Treatment planning for stereotactic radiosurgery of intra-cranial lesions. Int J Radiat Oncol Biol Phys. 1991 Aug; 21(3):683-93.
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  229. Tsai JS, Buck BA, Svensson GK, Alexander E, Cheng CW, Mannarino EG, Loeffler JS. Quality assurance in stereotactic radiosurgery using a standard linear accelerator. Int J Radiat Oncol Biol Phys. 1991 Aug; 21(3):737-48.
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  230. Hochberg FH, Loeffler JS, Prados M. The therapy of primary brain lymphoma. J Neurooncol. 1991 Jun; 10(3):191-201.
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  231. Carvalho PA, Schwartz RB, Alexander E, Loeffler JS, Zimmerman RE, Nagel JS, Holman BL. Extracranial metastatic glioblastoma: appearance on thallium-201-chloride/technetium-99m-HMPAO SPECT images. J Nucl Med. 1991 Feb; 32(2):322-4.
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  232. Alexander E, Loeffler JS. Radiosurgery: enhancement of clinical excellence. Introduction. Stereotact Funct Neurosurg. 1991; 57(1-2):5-6.
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  233. Loeffler JS, Alexander E, Wen PY, Shea WM, Coleman CN, Kooy HM, Fine HA, Nedzi LA, Silver B, Riese NE, et al. Results of stereotactic brachytherapy used in the initial management of patients with glioblastoma. J Natl Cancer Inst. 1990 Dec 19; 82(24):1918-21.
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  234. Loeffler JS, Alexander E, Hochberg FH, Wen PY, Morris JH, Schoene WC, Siddon RL, Morse RH, Black PM. Clinical patterns of failure following stereotactic interstitial irradiation for malignant gliomas. Int J Radiat Oncol Biol Phys. 1990 Dec; 19(6):1455-62.
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  235. Loeffler JS, Rossitch E, Siddon R, Moore MR, Rockoff MA, Alexander E. Role of stereotactic radiosurgery with a linear accelerator in treatment of intracranial arteriovenous malformations and tumors in children. Pediatrics. 1990 May; 85(5):774-82.
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  236. Wen P, Loeffler JS, Morris JH, Lampson LA. The effects of irradiation on major histocompatibility complex expression and lymphocytic infiltration in the normal rat brain and the 9L gliosarcoma brain tumor model. J Neuroimmunol. 1990 May; 27(2-3):239-44.
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  237. Loeffler JS, Siddon RL, Wen PY, Nedzi LA, Alexander E. Stereotactic radiosurgery of the brain using a standard linear accelerator: a study of early and late effects. Radiother Oncol. 1990 Apr; 17(4):311-21.
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  238. Loeffler JS, Kooy HM, Wen PY, Fine HA, Cheng CW, Mannarino EG, Tsai JS, Alexander E. The treatment of recurrent brain metastases with stereotactic radiosurgery. J Clin Oncol. 1990 Apr; 8(4):576-82.
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  239. Loeffler JS, Alexander E. The role of stereotactic radiosurgery in the management of intracranial tumors. Oncology (Williston Park). 1990 Mar; 4(3):21-31; discussion 32, 37, 41.
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  240. Pfeffer MR, Loeffler JS. Pituitary tumors. Curr Opin Oncol. 1990 Feb; 2(1):73-8.
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  241. Loeffler JS, Harris JR, Dahlberg WK, Little JB. In vitro radiosensitivity of human diploid fibroblasts derived from women with unusually sensitive clinical responses to definitive radiation therapy for breast cancer. Radiat Res. 1990 Feb; 121(2):227-31.
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  242. Pierce SM, Barnes PD, Loeffler JS, McGinn C, Tarbell NJ. Definitive radiation therapy in the management of symptomatic patients with optic glioma. Survival and long-term effects. Cancer. 1990 Jan 1; 65(1):45-52.
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  243. Kretschmar CS, Tarbell NJ, Kupsky W, Lavally BL, Loeffler JS, Wolfe L, Strand R, Scott RM, Sallan SE. Pre-irradiation chemotherapy for infants and children with medulloblastoma: a preliminary report. J Neurosurg. 1989 Dec; 71(6):820-5.
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  244. Loeffler JS, Alexander E, Siddon RL, Saunders WM, Coleman CN, Winston KR. Stereotactic radiosurgery for intracranial arteriovenous malformations using a standard linear accelerator. Int J Radiat Oncol Biol Phys. 1989 Sep; 17(3):673-7.
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  245. Alexander E, Siddon RL, Loeffler JS. The acute onset of nausea and vomiting following stereotactic radiosurgery: correlation with total dose to area postrema. Surg Neurol. 1989 Jul; 32(1):40-4.
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  246. Loeffler JS, Kretschmar CS, Sallan SE, LaVally BL, Winston KR, Fischer EG, Tarbell NJ. Pre-radiation chemotherapy for infants and poor prognosis children with medulloblastoma. Int J Radiat Oncol Biol Phys. 1988 Jul; 15(1):177-81.
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  247. Hughes EN, Shillito J, Sallan SE, Loeffler JS, Cassady JR, Tarbell NJ. Medulloblastoma at the joint center for radiation therapy between 1968 and 1984. The influence of radiation dose on the patterns of failure and survival. Cancer. 1988 May 15; 61(10):1992-8.
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  248. Loeffler JS, Rosen EM, Niloff JM, Howes AE, Knapp RC. Whole abdominal irradiation for tumors of the uterine corpus. Cancer. 1988 Apr 1; 61(7):1332-5.
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  249. Loeffler JS, Tarbell NJ, Garber JR, Mauch P. The development of Graves' disease following radiation therapy in Hodgkin's disease. Int J Radiat Oncol Biol Phys. 1988 Jan; 14(1):175-8.
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  250. Lederman GS, Recht A, Loeffler JS, Dubuisson D, Kleefield J, Schnitt SJ. Craniopharyngioma in an elderly patient. Cancer. 1987 Sep 1; 60(5):1077-80.
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  251. Loeffler JS, Leopold KA, Recht A, Weinstein HJ, Tarbell NJ. Emergency prebiopsy radiation for mediastinal masses: impact on subsequent pathologic diagnosis and outcome. J Clin Oncol. 1986 May; 4(5):716-21.
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  252. Loeffler JS, Tarbell NJ, Kozakewich H, Cassady JR, Weinstein HJ. Primary lymphoma of bone in children: analysis of treatment results with adriamycin, prednisone, Oncovin (APO), and local radiation therapy. J Clin Oncol. 1986 Apr; 4(4):496-501.
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  253. Loeffler JS, Larson DA, Clark JR, Weichselbaum RR, Norris CM, Ervin TJ. Treatment of perineural metastasis from squamous carcinoma of the skin with aggressive combination chemotherapy and irradiation. J Surg Oncol. 1985 Jul; 29(3):181-3.
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  254. Loeffler JS, Ervin TJ, Mauch P, Skarin A, Weinstein HJ, Canellos G, Cassady JR. Primary lymphomas of the central nervous system: patterns of failure and factors that influence survival. J Clin Oncol. 1985 Apr; 3(4):490-4.
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  255. Becker RC, Loeffler JS, Leopold KA, Underwood DA. Primary tumors of the heart: a review with emphasis on diagnosis and potential treatment modalities. Semin Surg Oncol. 1985; 1(4):161-70.
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  256. Loeffler JS, Leslie NT, Cassady JR. Case 10-1984: orbital rhabdomyosarcoma. N Engl J Med. 1984 Jul 26; 311(4):262-3.
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  257. Loeffler J, Eisenberg P, Glicksman AS, Leith JT. Sensitivity of cell subpopulations obtained from a heterogeneous human colon adenocarcinoma to ultraviolet light. Radiat Res. 1983 Oct; 96(1):211-7.
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  258. Kinsella TJ, Loeffler JS, Fraass BA, Tepper J. Extremity preservation by combined modality therapy in sarcomas of the hand and foot: an analysis of local control, disease free survival and functional result. Int J Radiat Oncol Biol Phys. 1983 Aug; 9(8):1115-9.
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  259. Loeffler JS, Glicksman AS, Tefft M, Gelch M. Treatment of spinal cord compression: a retrospective analysis. Med Pediatr Oncol. 1983; 11(5):347-51.
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