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Last Name
Institution

Elazer Reuven Edelman, PH.D., M.D.

TitleProfessor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressMass Institute of Technology
Health Sciences and Technology Bldg E24, Rm 438
77 Massachusetts Ave
Cambridge MA 02139
Phone617/253-1569
Fax617/253-2514

 Mentoring 
 completed student projects
Disease Responsive Materials for Orthopedic Applications
Summer, 06/01/13 - 08/31/13
Embedding Endothelial Cells in Acellular Bone Matrices
Summer, 06/13/11 - 08/05/11
mTORC1, mTORC2, and the Akt Signaling Pathway in Vascular Smooth Muscle Behavior
Summer, 06/01/07 - 08/31/07
Improving tumor detection and visualization through the use of pre-targeting
Summer, 06/01/09 - 08/31/09
Aga-associated Changes in the Inflammatory and Proliferative Response to Vascular Injury
Summer, 06/24/01 - 08/18/01
Effect of Blood Flow on Drug Distribution in Drug-eluting Stents
Summer, 06/01/08 - 08/31/08
Ultrastructural Basis for Macromolecular Transport in Arterial Tissue
Summer, 07/01/99 - 08/31/99
Characterizing and Regulating the HDL Receptor, SR-B1, in Vascular Smooth Muscle Cells
Summer, 06/01/99 - 08/31/99
The Role of Altered Fluid Flow in Stent Thrombogenicity in Sub-optimal Interventional Settings
Summer, 06/20/11 - 08/12/11
The Role of HSPGs in Various Models of Vascular Disease
Summer, 05/23/06 - 05/23/07

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Turjman AS, Turjman F, Edelman ER. Role of fluid dynamics and inflammation in intracranial aneurysm formation. Circulation. 2014 Jan 21; 129(3):373-82.
    View in: PubMed
  2. Koskinas KC, Chatzizisis YS, Papafaklis MI, Coskun AU, Baker AB, Jarolim P, Antoniadis A, Edelman ER, Stone PH, Feldman CL. Synergistic effect of local endothelial shear stress and systemic hypercholesterolemia on coronary atherosclerotic plaque progression and composition in pigs. Int J Cardiol. 2013 Nov 30; 169(6):394-401.
    View in: PubMed
  3. Nickmann M, Saemisch M, Wilbert-Lampen U, Nickel T, Edelman ER, Methe H. Cell matrix contact modifies endothelial major histocompatibility complex class II expression in high-glucose environment. Am J Physiol Heart Circ Physiol. 2013 Dec; 305(11):H1592-9.
    View in: PubMed
  4. Rosàs E, Santomá P, Duran-Frigola M, Hernandez B, Llinàs MC, Ruiz-González R, Nonell S, Sánchez-García D, Edelman ER, Balcells M. Modifications of Microvascular EC Surface Modulate Phototoxicity of a Porphycene anti-ICAM-1 Immunoconjugate; Therapeutic Implications. Langmuir. 2013 Aug 6; 29(31):9734-43.
    View in: PubMed
  5. Maslov MY, Edelman ER, Wei AE, Pezone MJ, Lovich MA. High concentrations of drug in target tissues following local controlled release are utilized for both drug distribution and biologic effect: An example with epicardial inotropic drug delivery. J Control Release. 2013 Oct 28; 171(2):201-7.
    View in: PubMed
  6. Chitalia V, Shivanna S, Martorell J, Meyer R, Edelman E, Rahimi N. c-Cbl, a Ubiquitin E3 Ligase That Targets Active ß-Catenin: A NOVEL LAYER OF Wnt SIGNALING REGULATION. J Biol Chem. 2013 Aug 9; 288(32):23505-17.
    View in: PubMed
  7. Orekhov AN, Sobenin IA, Korneev NV, Kirichenko TV, Myasoedova VA, Melnichenko AA, Balcells M, Edelman ER, Bobryshev YV. Anti-atherosclerotic therapy based on botanicals. Recent Pat Cardiovasc Drug Discov. 2013 Jun 5; 8(1):56-66.
    View in: PubMed
  8. Koskinas KC, Sukhova GK, Baker AB, Papafaklis MI, Chatzizisis YS, Coskun AU, Quillard T, Jonas M, Maynard C, Antoniadis AP, Shi GP, Libby P, Edelman ER, Feldman CL, Stone PH. Thin-capped atheromata with reduced collagen content in pigs develop in coronary arterial regions exposed to persistently low endothelial shear stress. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1494-504.
    View in: PubMed
  9. Kolachalama VB, Pacetti SD, Franses JW, Stankus JJ, Zhao HQ, Shazly T, Nikanorov A, Schwartz LB, Tzafriri AR, Edelman ER. Mechanisms of tissue uptake and retention in zotarolimus-coated balloon therapy. Circulation. 2013 May 21; 127(20):2047-55.
    View in: PubMed
  10. Franses JW, Drosu NC, Gibson WJ, Chitalia VC, Edelman ER. Dysfunctional endothelial cells directly stimulate cancer inflammation and metastasis. Int J Cancer. 2013 Sep 15; 133(6):1334-44.
    View in: PubMed
  11. O'Brien CC, Kolachalama VB, Barber TJ, Simmons A, Edelman ER. Impact of flow pulsatility on arterial drug distribution in stent-based therapy. J Control Release. 2013 Jun 10; 168(2):115-24.
    View in: PubMed
  12. Jolicœur EM, Banai S, Henry TD, Schwartz M, Doucet S, White CJ, Edelman E, Verheye S. A phase II, sham-controlled, double-blinded study testing the safety and efficacy of the coronary sinus reducer in patients with refractory angina: study protocol for a randomized controlled trial. Trials. 2013; 14(1):46.
    View in: PubMed
  13. Rosas E, Sobenin I, Orekhov A, Edelman ER, Balcells M. Importance of Receptor-targeted Systems in the Battle Against Atherosclerosis. Curr Pharm Des. 2013; 19(33):5897-903.
    View in: PubMed
  14. Chitalia VC, Shivanna S, Martorell J, Balcells M, Bosch I, Kolandaivelu K, Edelman ER. Uremic serum and solutes increase post-vascular interventional thrombotic risk through altered stability of smooth muscle cell tissue factor. Circulation. 2013 Jan 22; 127(3):365-76.
    View in: PubMed
  15. Banai S, Finkelstein A, Almagor Y, Assali A, Hasin Y, Rosenschein U, Apruzzese P, Lansky AJ, Kume T, Edelman ER. Targeted anti-inflammatory systemic therapy for restenosis: The Biorest Liposomal Alendronate with Stenting sTudy (BLAST)-a double blind, randomized clinical trial. Am Heart J. 2013 Feb; 165(2):234-240.e1.
    View in: PubMed
  16. Murikipudi S, Methe H, Edelman ER. The effect of substrate modulus on the growth and function of matrix-embedded endothelial cells. Biomaterials. 2013 Jan; 34(3):677-84.
    View in: PubMed
  17. Oliva N, Shitreet S, Abraham E, Stanley B, Edelman ER, Artzi N. Natural tissue microenvironmental conditions modulate adhesive material performance. Langmuir. 2012 Oct 30; 28(43):15402-9.
    View in: PubMed
  18. Banai S, Jolicoeur EM, Schwartz M, Garceau P, Biner S, Tanguay JF, Cartier R, Verheye S, White CJ, Edelman E. Tiara: a novel catheter-based mitral valve bioprosthesis: initial experiments and short-term pre-clinical results. J Am Coll Cardiol. 2012 Oct 9; 60(15):1430-1.
    View in: PubMed
  19. Carlyle WC, McClain JB, Tzafriri AR, Bailey L, Zani BG, Markham PM, Stanley JR, Edelman ER. Enhanced drug delivery capabilities from stents coated with absorbable polymer and crystalline drug. J Control Release. 2012 Sep 28; 162(3):561-7.
    View in: PubMed
  20. Nugent HM, Ng YS, White D, Groothius A, Kanner G, Edelman ER. Ultrasound-guided percutaneous delivery of tissue-engineered endothelial cells to the adventitia of stented arteries controls the response to vascular injury in a porcine model. J Vasc Surg. 2012 Oct; 56(4):1078-88.
    View in: PubMed
  21. Indolfi L, Baker AB, Edelman ER. The role of scaffold microarchitecture in engineering endothelial cell immunomodulation. Biomaterials. 2012 Oct; 33(29):7019-27.
    View in: PubMed
  22. Tzafriri AR, Groothuis A, Price GS, Edelman ER. Stent elution rate determines drug deposition and receptor-mediated effects. J Control Release. 2012 Aug 10; 161(3):918-26.
    View in: PubMed
  23. Edelman ER, LaMarco K. Clinician-investigators as translational bioscientists: shaping a seamless identity. Sci Transl Med. 2012 May 23; 4(135):135fs14.
    View in: PubMed
  24. Baker AB, Gibson WJ, Kolachalama VB, Golomb M, Indolfi L, Spruell C, Zcharia E, Vlodavsky I, Edelman ER. Heparanase regulates thrombosis in vascular injury and stent-induced flow disturbance. J Am Coll Cardiol. 2012 Apr 24; 59(17):1551-60.
    View in: PubMed
  25. Martorell J, Santomá P, Molins JJ, García-Granada AA, Bea JA, Edelman ER, Balcells M. Engineered arterial models to correlate blood flow to tissue biological response. Ann N Y Acad Sci. 2012 Apr; 1254:51-6.
    View in: PubMed
  26. Aronson D, Edelman ER. Role of CABG in the management of obstructive coronary arterial disease in patients with diabetes mellitus. Curr Opin Pharmacol. 2012 Apr; 12(2):134-41.
    View in: PubMed
  27. Jang E, Albadawi H, Watkins MT, Edelman ER, Baker AB. Syndecan-4 proteoliposomes enhance fibroblast growth factor-2 (FGF-2)-induced proliferation, migration, and neovascularization of ischemic muscle. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1679-84.
    View in: PubMed
  28. Franses JW, Edelman ER. The evolution of endothelial regulatory paradigms in cancer biology and vascular repair. Cancer Res. 2011 Dec 15; 71(24):7339-44.
    View in: PubMed
  29. Shazly T, Kolachalama VB, Ferdous J, Oberhauser JP, Hossainy S, Edelman ER. Assessment of material by-product fate from bioresorbable vascular scaffolds. Ann Biomed Eng. 2012 Apr; 40(4):955-65.
    View in: PubMed
  30. Edelman ER, FitzGerald GA. A rattle bag of science and the art of translation. Sci Transl Med. 2011 Oct 12; 3(104):104ed3.
    View in: PubMed
  31. Artzi N, Oliva N, Puron C, Shitreet S, Artzi S, bon Ramos A, Groothuis A, Sahagian G, Edelman ER. In vivo and in vitro tracking of erosion in biodegradable materials using non-invasive fluorescence imaging. Nat Mater. 2011 Sep; 10(9):704-9.
    View in: PubMed
  32. Chitalia VC, Murikipudi S, Indolfi L, Rabadi L, Valdez R, Franses JW, Edelman ER. Matrix-embedded endothelial cells are protected from the uremic milieu. Nephrol Dial Transplant. 2011 Dec; 26(12):3858-65.
    View in: PubMed
  33. Balcells M, Edelman ER. [Models of human vascular disease: is there an animal of la mancha?]. Rev Esp Cardiol. 2011 Sep; 64(9):739-42.
    View in: PubMed
  34. Lovich MA, Wei AE, Maslov MY, Wu PI, Edelman ER. Local epicardial inotropic drug delivery allows targeted pharmacologic intervention with preservation of myocardial loading conditions. J Pharm Sci. 2011 Nov; 100(11):4993-5006.
    View in: PubMed
  35. Edelman ER, Leon MB. The fiber of modern society. Sci Transl Med. 2011 Jun 29; 3(89):89cm14.
    View in: PubMed
  36. Joynt KE, Edelman ER. Letter by Joynt and Edelman regarding article, "Iatrogenic giant Osborn waves". Circulation. 2011 Mar 29; 123(12):e390; author reply e391.
    View in: PubMed
  37. Kolandaivelu K, Swaminathan R, Gibson WJ, Kolachalama VB, Nguyen-Ehrenreich KL, Giddings VL, Coleman L, Wong GK, Edelman ER. Stent thrombogenicity early in high-risk interventional settings is driven by stent design and deployment and protected by polymer-drug coatings. Circulation. 2011 Apr 5; 123(13):1400-9.
    View in: PubMed
  38. Chatzizisis YS, Baker AB, Sukhova GK, Koskinas KC, Papafaklis MI, Beigel R, Jonas M, Coskun AU, Stone BV, Maynard C, Shi GP, Libby P, Feldman CL, Edelman ER, Stone PH. Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs. Circulation. 2011 Feb 15; 123(6):621-30.
    View in: PubMed
  39. Schubert SY, Benarroch A, Monter-Solans J, Edelman ER. Primary monocytes regulate endothelial cell survival through secretion of angiopoietin-1 and activation of endothelial Tie2. Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4):870-5.
    View in: PubMed
  40. Franses JW, Baker AB, Chitalia VC, Edelman ER. Stromal endothelial cells directly influence cancer progression. Sci Transl Med. 2011 Jan 19; 3(66):66ra5.
    View in: PubMed
  41. Shazly TM, Baker AB, Naber JR, Bon A, Van Vliet KJ, Edelman ER. Augmentation of postswelling surgical sealant potential of adhesive hydrogels. J Biomed Mater Res A. 2010 Dec 15; 95(4):1159-69.
    View in: PubMed
  42. Baker AB, Chatzizisis YS, Beigel R, Jonas M, Stone BV, Coskun AU, Maynard C, Rogers C, Koskinas KC, Feldman CL, Stone PH, Edelman ER. Regulation of heparanase expression in coronary artery disease in diabetic, hyperlipidemic swine. Atherosclerosis. 2010 Dec; 213(2):436-42.
    View in: PubMed
  43. Artzi N, Zeiger A, Boehning F, bon Ramos A, Van Vliet K, Edelman ER. Tuning adhesion failure strength for tissue-specific applications. Acta Biomater. 2011 Jan; 7(1):67-74.
    View in: PubMed
  44. Edelman ER, Joynt K. J waves of Osborn revisited. J Am Coll Cardiol. 2010 May 18; 55(20):2287.
    View in: PubMed
  45. Balcells M, Martorell J, Olivé C, Santacana M, Chitalia V, Cardoso AA, Edelman ER. Smooth muscle cells orchestrate the endothelial cell response to flow and injury. Circulation. 2010 May 25; 121(20):2192-9.
    View in: PubMed
  46. Koskinas KC, Feldman CL, Chatzizisis YS, Coskun AU, Jonas M, Maynard C, Baker AB, Papafaklis MI, Edelman ER, Stone PH. Natural history of experimental coronary atherosclerosis and vascular remodeling in relation to endothelial shear stress: a serial, in vivo intravascular ultrasound study. Circulation. 2010 May 18; 121(19):2092-101.
    View in: PubMed
  47. Zani BG, Edelman ER. Cellular bridges: Routes for intercellular communication and cell migration. Commun Integr Biol. 2010 May; 3(3):215-20.
    View in: PubMed
  48. Brown L, Edelman ER. Optimal control of blood glucose: the diabetic patient or the machine? Sci Transl Med. 2010 Apr 14; 2(27):27ps18.
    View in: PubMed
  49. Aronson D, Edelman ER. Revascularization for coronary artery disease in diabetes mellitus: angioplasty, stents and coronary artery bypass grafting. Rev Endocr Metab Disord. 2010 Mar; 11(1):75-86.
    View in: PubMed
  50. Schubert SY, Benarroch A, Monter-Solans J, Edelman ER. Monocyte activation state regulates monocyte-induced endothelial proliferation through Met signaling. Blood. 2010 Apr 22; 115(16):3407-12.
    View in: PubMed
  51. Zani BG, Indolfi L, Edelman ER. Tubular bridges for bronchial epithelial cell migration and communication. PLoS One. 2010; 5(1):e8930.
    View in: PubMed
  52. Methe H, Nanasato M, Spognardi AM, Groothuis A, Edelman ER. T-helper 2 cells are essential for modulation of vascular repair by allogeneic endothelial cells. J Heart Lung Transplant. 2010 Apr; 29(4):479-86.
    View in: PubMed
  53. Desai AS, Chutkow WA, Edelman E, Economy KE, Dec GW. Clinical problem-solving. A crisis in late pregnancy. N Engl J Med. 2009 Dec 3; 361(23):2271-7.
    View in: PubMed
  54. Kolachalama VB, Levine EG, Edelman ER. Luminal flow amplifies stent-based drug deposition in arterial bifurcations. PLoS One. 2009; 4(12):e8105.
    View in: PubMed
  55. Tzafriri AR, Vukmirovic N, Kolachalama VB, Astafieva I, Edelman ER. Lesion complexity determines arterial drug distribution after local drug delivery. J Control Release. 2010 Mar 19; 142(3):332-8.
    View in: PubMed
  56. Koskinas KC, Chatzizisis YS, Baker AB, Edelman ER, Stone PH, Feldman CL. The role of low endothelial shear stress in the conversion of atherosclerotic lesions from stable to unstable plaque. Curr Opin Cardiol. 2009 Nov; 24(6):580-90.
    View in: PubMed
  57. Nugent HM, Ng YS, White D, Groothius A, Kanner G, Edelman ER. Delivery site of perivascular endothelial cell matrices determines control of stenosis in a porcine femoral stent model. J Vasc Interv Radiol. 2009 Dec; 20(12):1617-24.
    View in: PubMed
  58. Artzi N, Shazly T, Baker AB, Bon A, Edelman ER. Aldehyde-amine chemistry enables modulated biosealants with tissue-specific adhesion. Adv Mater. 2009 Sep 4; 21(32-33):3399-403.
    View in: PubMed
  59. Artzi N, Shazly T, Crespo C, Ramos AB, Chenault HK, Edelman ER. Characterization of star adhesive sealants based on PEG/dextran hydrogels. Macromol Biosci. 2009 Aug 11; 9(8):754-65.
    View in: PubMed
  60. Mobine HR, Engelmayr GC, Moussazadeh N, Anwar TR, Freed LE, Edelman ER. Encapsulated pheochromocytoma cells secrete potent noncatecholamine factors. Tissue Eng Part A. 2009 Jul; 15(7):1719-28.
    View in: PubMed
  61. Le KN, Hwang CW, Tzafriri AR, Lovich MA, Hayward A, Edelman ER. Vascular regeneration by local growth factor release is self-limited by microvascular clearance. Circulation. 2009 Jun 9; 119(22):2928-35.
    View in: PubMed
  62. Maron BA, Kolandaivelu K, Rhee DK, Bukhman AK, Edelman ER. Echocardiographic capture of right ventricular wall rupture during inferior wall acute myocardial infarction. Am J Cardiol. 2009 May 15; 103(10):1478-80.
    View in: PubMed
  63. Tzafriri AR, Levin AD, Edelman ER. Diffusion-limited binding explains binary dose response for local arterial and tumour drug delivery. Cell Prolif. 2009 Jun; 42(3):348-63.
    View in: PubMed
  64. Mobine HR, Baker AB, Wang L, Wakimoto H, Jacobsen KC, Seidman CE, Seidman JG, Edelman ER. Pheochromocytoma-induced cardiomyopathy is modulated by the synergistic effects of cell-secreted factors. Circ Heart Fail. 2009 Mar; 2(2):121-8.
    View in: PubMed
  65. Wu PI, Minisini S, Edelman ER. Intramuscular drug transport under mechanical loading: resonance between tissue function and uptake. J Control Release. 2009 Jun 5; 136(2):99-109.
    View in: PubMed
  66. Alexander I, Edelman ER, Methe H. Function and mode of regulation of endothelial major histocompatibility complex class II. Cell Transplant. 2009; 18(3):255-9.
    View in: PubMed
  67. Hess S, Methe H, Kim JO, Edelman ER. NF-kappaB activity in endothelial cells is modulated by cell substratum interactions and influences chemokine-mediated adhesion of natural killer cells. Cell Transplant. 2009; 18(3):261-73.
    View in: PubMed
  68. Baker AB, Groothuis A, Jonas M, Ettenson DS, Shazly T, Zcharia E, Vlodavsky I, Seifert P, Edelman ER. Heparanase alters arterial structure, mechanics, and repair following endovascular stenting in mice. Circ Res. 2009 Feb 13; 104(3):380-7.
    View in: PubMed
  69. Clyne AM, Zhu H, Edelman ER. Elevated fibroblast growth factor-2 increases tumor necrosis factor-alpha induced endothelial cell death in high glucose. J Cell Physiol. 2008 Oct; 217(1):86-92.
    View in: PubMed
  70. Schwartz RS, Edelman E, Virmani R, Carter A, Granada JF, Kaluza GL, Chronos NA, Robinson KA, Waksman R, Weinberger J, Wilson GJ, Wilensky RL. Drug-eluting stents in preclinical studies: updated consensus recommendations for preclinical evaluation. Circ Cardiovasc Interv. 2008 Oct; 1(2):143-53.
    View in: PubMed
  71. Kolachalama VB, Tzafriri AR, Arifin DY, Edelman ER. Luminal flow patterns dictate arterial drug deposition in stent-based delivery. J Control Release. 2009 Jan 5; 133(1):24-30.
    View in: PubMed
  72. Shazly TM, Artzi N, Boehning F, Edelman ER. Viscoelastic adhesive mechanics of aldehyde-mediated soft tissue sealants. Biomaterials. 2008 Dec; 29(35):4584-91.
    View in: PubMed
  73. Wu PI, Edelman ER. Structural biomechanics modulate intramuscular distribution of locally delivered drugs. J Biomech. 2008 Sep 18; 41(13):2884-91.
    View in: PubMed
  74. Chatzizisis YS, Jonas M, Beigel R, Coskun AU, Baker AB, Stone BV, Maynard C, Gerrity RG, Daley W, Edelman ER, Feldman CL, Stone PH. Attenuation of inflammation and expansive remodeling by Valsartan alone or in combination with Simvastatin in high-risk coronary atherosclerotic plaques. Atherosclerosis. 2009 Apr; 203(2):387-94.
    View in: PubMed
  75. Balakrishnan B, Dooley J, Kopia G, Edelman ER. Thrombus causes fluctuations in arterial drug delivery from intravascular stents. J Control Release. 2008 Nov 12; 131(3):173-80.
    View in: PubMed
  76. Balcells M, Wallins JS, Edelman ER. Amyloid beta toxicity dependent upon endothelial cell state. Neurosci Lett. 2008 Aug 29; 441(3):319-22.
    View in: PubMed
  77. Baker AB, Ettenson DS, Jonas M, Nugent MA, Iozzo RV, Edelman ER. Endothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF-beta signaling pathway. Circ Res. 2008 Aug 1; 103(3):289-97.
    View in: PubMed
  78. Mi LY, Ettenson DS, Edelman ER. Phospholipase C-delta extends intercellular signalling range and responses to injury-released growth factors in non-excitable cells. Cell Prolif. 2008 Aug; 41(4):671-90.
    View in: PubMed
  79. Zani BG, Kojima K, Vacanti CA, Edelman ER. Tissue-engineered endothelial and epithelial implants differentially and synergistically regulate airway repair. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):7046-51.
    View in: PubMed
  80. Methe H, Hess S, Edelman ER. The effect of three-dimensional matrix-embedding of endothelial cells on the humoral and cellular immune response. Semin Immunol. 2008 Apr; 20(2):117-22.
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  81. Danenberg HD, Grad E, Swaminathan RV, Chen Z, Seifert P, Szalai AJ, Lotan C, Simon DI, Edelman ER. Neointimal formation is reduced after arterial injury in human crp transgenic mice. Atherosclerosis. 2008 Nov; 201(1):85-91.
    View in: PubMed
  82. Chatzizisis YS, Jonas M, Coskun AU, Beigel R, Stone BV, Maynard C, Gerrity RG, Daley W, Rogers C, Edelman ER, Feldman CL, Stone PH. Prediction of the localization of high-risk coronary atherosclerotic plaques on the basis of low endothelial shear stress: an intravascular ultrasound and histopathology natural history study. Circulation. 2008 Feb 26; 117(8):993-1002.
    View in: PubMed
  83. Epstein H, Grad E, Golomb M, Koroukhov N, Edelman ER, Golomb G, Danenberg HD. Innate immunity has a dual effect on vascular healing: suppression and aggravation of neointimal formation and remodeling post-endotoxin challenge. Atherosclerosis. 2008 Jul; 199(1):41-6.
    View in: PubMed
  84. Schubert SY, Benarroch A, Ostvang J, Edelman ER. Regulation of endothelial cell proliferation by primary monocytes. Arterioscler Thromb Vasc Biol. 2008 Jan; 28(1):97-104.
    View in: PubMed
  85. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Stone PH, Feldman CL. Risk stratification of individual coronary lesions using local endothelial shear stress: a new paradigm for managing coronary artery disease. Curr Opin Cardiol. 2007 Nov; 22(6):552-64.
    View in: PubMed
  86. Nugent HM, Sjin RT, White D, Milton LG, Manson RJ, Lawson JH, Edelman ER. Adventitial endothelial implants reduce matrix metalloproteinase-2 expression and increase luminal diameter in porcine arteriovenous grafts. J Vasc Surg. 2007 Sep; 46(3):548-556.
    View in: PubMed
  87. Methe H, Hess S, Edelman ER. Endothelial immunogenicity--a matter of matrix microarchitecture. Thromb Haemost. 2007 Aug; 98(2):278-82.
    View in: PubMed
  88. Balakrishnan B, Dooley JF, Kopia G, Edelman ER. Intravascular drug release kinetics dictate arterial drug deposition, retention, and distribution. J Control Release. 2007 Nov 6; 123(2):100-8.
    View in: PubMed
  89. Methe H, Hess S, Edelman ER. Endothelial cell-matrix interactions determine maturation of dendritic cells. Eur J Immunol. 2007 Jul; 37(7):1773-84.
    View in: PubMed
  90. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol. 2007 Jun 26; 49(25):2379-93.
    View in: PubMed
  91. Grad E, Golomb M, Mor-Yosef I, Koroukhov N, Lotan C, Edelman ER, Danenberg HD. Transgenic expression of human C-reactive protein suppresses endothelial nitric oxide synthase expression and bioactivity after vascular injury. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H489-95.
    View in: PubMed
  92. Tzafriri AR, Edelman ER. Endosomal receptor kinetics determine the stability of intracellular growth factor signalling complexes. Biochem J. 2007 Mar 15; 402(3):537-49.
    View in: PubMed
  93. Hamik A, Lin Z, Kumar A, Balcells M, Sinha S, Katz J, Feinberg MW, Gerzsten RE, Edelman ER, Jain MK. Kruppel-like factor 4 regulates endothelial inflammation. J Biol Chem. 2007 May 4; 282(18):13769-79.
    View in: PubMed
  94. Thomas AH, Edelman ER, Stultz CM. Collagen fragments modulate innate immunity. Exp Biol Med (Maywood). 2007 Mar; 232(3):406-11.
    View in: PubMed
  95. Morss AS, Edelman ER. Glucose modulates basement membrane fibroblast growth factor-2 via alterations in endothelial cell permeability. J Biol Chem. 2007 May 11; 282(19):14635-44.
    View in: PubMed
  96. Methe H, Groothuis A, Sayegh MH, Edelman ER. Matrix adherence of endothelial cells attenuates immune reactivity: induction of hyporesponsiveness in allo- and xenogeneic models. FASEB J. 2007 May; 21(7):1515-26.
    View in: PubMed
  97. Danenberg HD, Kantak N, Grad E, Swaminathan RV, Lotan C, Edelman ER. C-reactive protein promotes monocyte-platelet aggregation: an additional link to the inflammatory-thrombotic intricacy. Eur J Haematol. 2007 Mar; 78(3):246-52.
    View in: PubMed
  98. Methe H, Balcells M, Alegret Mdel C, Santacana M, Molins B, Hamik A, Jain MK, Edelman ER. Vascular bed origin dictates flow pattern regulation of endothelial adhesion molecule expression. Am J Physiol Heart Circ Physiol. 2007 May; 292(5):H2167-75.
    View in: PubMed
  99. Rami Tzafriri A, Edelman ER. Quasi-steady-state kinetics at enzyme and substrate concentrations in excess of the Michaelis-Menten constant. J Theor Biol. 2007 Apr 21; 245(4):737-48.
    View in: PubMed
  100. Methe H, Edelman ER. Tissue engineering of endothelial cells and the immune response. Transplant Proc. 2006 Dec; 38(10):3293-9.
    View in: PubMed
  101. Methe H, Edelman ER. Cell-matrix contact prevents recognition and damage of endothelial cells in states of heightened immunity. Circulation. 2006 Jul 4; 114(1 Suppl):I233-8.
    View in: PubMed
  102. Richter Y, Edelman ER. Cardiology is flow. Circulation. 2006 Jun 13; 113(23):2679-82.
    View in: PubMed
  103. Rogers C, Edelman ER. Pushing drug-eluting stents into uncharted territory: simpler than you think--more complex than you imagine. Circulation. 2006 May 16; 113(19):2262-5.
    View in: PubMed
  104. Levin AD, Jonas M, Hwang CW, Edelman ER. Local and systemic drug competition in drug-eluting stent tissue deposition properties. J Control Release. 2005 Dec 5; 109(1-3):236-43.
    View in: PubMed
  105. Costa LF, Balcells M, Edelman ER, Nadler LM, Cardoso AA. Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB. Blood. 2006 Jan 1; 107(1):285-92.
    View in: PubMed
  106. Methe H, Nugent HM, Groothuis A, Seifert P, Sayegh MH, Edelman ER. Matrix embedding alters the immune response against endothelial cells in vitro and in vivo. Circulation. 2005 Aug 30; 112(9 Suppl):I89-95.
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  107. Jonas M, Edelman ER, Groothuis A, Baker AB, Seifert P, Rogers C. Vascular neointimal formation and signaling pathway activation in response to stent injury in insulin-resistant and diabetic animals. Circ Res. 2005 Sep 30; 97(7):725-33.
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  108. Balcells M, Fernández Suárez M, Vázquez M, Edelman ER. Cells in fluidic environments are sensitive to flow frequency. J Cell Physiol. 2005 Jul; 204(1):329-35.
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  109. Methe H, Brunner S, Wiegand D, Nabauer M, Koglin J, Edelman ER. Enhanced T-helper-1 lymphocyte activation patterns in acute coronary syndromes. J Am Coll Cardiol. 2005 Jun 21; 45(12):1939-45.
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  110. Balakrishnan B, Tzafriri AR, Seifert P, Groothuis A, Rogers C, Edelman ER. Strut position, blood flow, and drug deposition: implications for single and overlapping drug-eluting stents. Circulation. 2005 Jun 7; 111(22):2958-65.
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  111. Tzafriri AR, Edelman ER. On the validity of the quasi-steady state approximation of bimolecular reactions in solution. J Theor Biol. 2005 Apr 7; 233(3):343-50.
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  112. Hwang CW, Levin AD, Jonas M, Li PH, Edelman ER. Thrombosis modulates arterial drug distribution for drug-eluting stents. Circulation. 2005 Apr 5; 111(13):1619-26.
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  113. Schwartz RS, Edelman ER, Carter A, Chronos NA, Rogers C, Robinson KA, Waksman R, Machan L, Weinberger J, Wilensky RL, Goode JL, Hottenstein OD, Zuckerman BD, Virmani R. Preclinical evaluation of drug-eluting stents for peripheral applications: recommendations from an expert consensus group. Circulation. 2004 Oct 19; 110(16):2498-505.
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  114. Kolandaivelu K, Edelman ER. Environmental influences on endovascular stent platelet reactivity: an in vitro comparison of stainless steel and gold surfaces. J Biomed Mater Res A. 2004 Aug 1; 70(2):186-93.
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  115. Tzafriri AR, Wu D, Edelman ER. Analysis of compartmental models of ligand-induced endocytosis. J Theor Biol. 2004 Jul 7; 229(1):127-38.
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  116. Levin AD, Vukmirovic N, Hwang CW, Edelman ER. Specific binding to intracellular proteins determines arterial transport properties for rapamycin and paclitaxel. Proc Natl Acad Sci U S A. 2004 Jun 22; 101(25):9463-7.
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  117. Richter Y, Groothuis A, Seifert P, Edelman ER. Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions. J Clin Invest. 2004 Jun; 113(11):1607-14.
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  118. Sapp JL, Cooper JM, Soejima K, Sorrell T, Lopera G, Satti SD, Koplan BA, Epstein LM, Edelman E, Rogers C, Stevenson WG. Deep myocardial ablation lesions can be created with a retractable needle-tipped catheter. Pacing Clin Electrophysiol. 2004 May; 27(5):594-9.
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  119. Rogers C, Huynh R, Seifert PA, Chevalier B, Schofer J, Edelman ER, Toegel G, Kuchela A, Woupio A, Kuntz RE, Macon ND. Embolic protection with filtering or occlusion balloons during saphenous vein graft stenting retrieves identical volumes and sizes of particulate debris. Circulation. 2004 Apr 13; 109(14):1735-40.
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  120. Wu D, Edelman ER. Resonance energy transfer for assessing the molecular integrity of proteins for local delivery. Biotechnol Bioeng. 2004 Feb 20; 85(4):406-12.
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  121. Tzafriri AR, Edelman ER. The total quasi-steady-state approximation is valid for reversible enzyme kinetics. J Theor Biol. 2004 Feb 7; 226(3):303-13.
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  122. Danenberg HD, Golomb G, Groothuis A, Gao J, Epstein H, Swaminathan RV, Seifert P, Edelman ER. Liposomal alendronate inhibits systemic innate immunity and reduces in-stent neointimal hyperplasia in rabbits. Circulation. 2003 Dec 2; 108(22):2798-804.
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  123. Janicki C, Hwang CW, Edelman ER. Dose model for stent-based delivery of a radioactive compound for the treatment of restenosis in coronary arteries. Med Phys. 2003 Oct; 30(10):2622-8.
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  124. Stultz CM, Edelman ER. A structural model that explains the effects of hyperglycemia on collagenolysis. Biophys J. 2003 Oct; 85(4):2198-204.
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  125. Danenberg HD, Szalai AJ, Swaminathan RV, Peng L, Chen Z, Seifert P, Fay WP, Simon DI, Edelman ER. Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice. Circulation. 2003 Aug 5; 108(5):512-5.
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  126. Edelman ER, Danenberg HD. Rapamycin for cardiac transplant rejection and vasculopathy: one stone, two birds? Circulation. 2003 Jul 8; 108(1):6-8.
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  127. Nugent HM, Edelman ER. Tissue engineering therapy for cardiovascular disease. Circ Res. 2003 May 30; 92(10):1068-78.
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  128. Hwang CW, Wu D, Edelman ER. Impact of transport and drug properties on the local pharmacology of drug-eluting stents. Int J Cardiovasc Intervent. 2003; 5(1):7-12.
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  129. Welt FG, Tso C, Edelman ER, Kjelsberg MA, Paolini JF, Seifert P, Rogers C. Leukocyte recruitment and expression of chemokines following different forms of vascular injury. Vasc Med. 2003; 8(1):1-7.
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  130. Kolandaivelu K, Edelman ER. Low background, pulsatile, in vitro flow circuit for modeling coronary implant thrombosis. J Biomech Eng. 2002 Dec; 124(6):662-8.
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  131. Nugent HM, Groothuis A, Seifert P, Guerraro JL, Nedelman M, Mohanakumar T, Edelman ER. Perivascular endothelial implants inhibit intimal hyperplasia in a model of arteriovenous fistulae: a safety and efficacy study in the pig. J Vasc Res. 2002 Nov-Dec; 39(6):524-33.
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  132. Stultz CM, Levin AD, Edelman ER. Phosphorylation-induced conformational changes in a mitogen-activated protein kinase substrate. Implications for tyrosine hydroxylase activation. J Biol Chem. 2002 Dec 6; 277(49):47653-61.
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  133. Schwartz RS, Edelman ER, Carter A, Chronos N, Rogers C, Robinson KA, Waksman R, Weinberger J, Wilensky RL, Jensen DN, Zuckerman BD, Virmani R. Drug-eluting stents in preclinical studies: recommended evaluation from a consensus group. Circulation. 2002 Oct 1; 106(14):1867-73.
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  134. Lewis EF, Edelman ER. Images in cardiovascular medicine. Acute ST depressions in a patient with idiopathic hypertrophic subaortic stenosis and normal coronary arteries. Circulation. 2002 Aug 6; 106(6):757-8.
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  135. Danenberg HD, Welt FG, Walker M, Seifert P, Toegel GS, Edelman ER. Systemic inflammation induced by lipopolysaccharide increases neointimal formation after balloon and stent injury in rabbits. Circulation. 2002 Jun 18; 105(24):2917-22.
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  136. Balcells M, Edelman ER. Effect of pre-adsorbed proteins on attachment, proliferation, and function of endothelial cells. J Cell Physiol. 2002 May; 191(2):155-61.
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  137. Hwang CW, Edelman ER. Arterial ultrastructure influences transport of locally delivered drugs. Circ Res. 2002 Apr 19; 90(7):826-32.
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  138. Welt FG, Woods TC, Edelman ER. Oral heparin prevents neointimal hyperplasia after arterial injury: inhibitory potential depends on type of vascular injury. Circulation. 2001 Dec 18; 104(25):3121-4.
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  139. Edelman ER. On causes: Hippocrates, Aristotle, Robert Koch, and the Dread Pirate Roberts. Circulation. 2001 Nov 20; 104(21):2509-12.
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  140. Woods TC, Blystone CR, Yoo J, Edelman ER. Activation of EphB2 and its ligands promotes vascular smooth muscle cell proliferation. J Biol Chem. 2002 Jan 18; 277(3):1924-7.
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  141. Lovich MA, Creel C, Hong K, Hwang CW, Edelman ER. Carrier proteins determine local pharmacokinetics and arterial distribution of paclitaxel. J Pharm Sci. 2001 Sep; 90(9):1324-35.
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  142. Nugent HM, Edelman ER. Endothelial implants provide long-term control of vascular repair in a porcine model of arterial injury. J Surg Res. 2001 Aug; 99(2):228-34.
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  143. Hwang CW, Wu D, Edelman ER. Physiological transport forces govern drug distribution for stent-based delivery. Circulation. 2001 Jul 31; 104(5):600-5.
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  144. Consi TR, Seifert PA, Triantafyllou MS, Edelman ER. The dorsal fin engine of the seahorse (Hippocampus sp.). J Morphol. 2001 Apr; 248(1):80-97.
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  145. Edelman ER, Seifert P, Groothuis A, Morss A, Bornstein D, Rogers C. Gold-coated NIR stents in porcine coronary arteries. Circulation. 2001 Jan 23; 103(3):429-34.
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  146. Drachman DE, Edelman ER, Seifert P, Groothuis AR, Bornstein DA, Kamath KR, Palasis M, Yang D, Nott SH, Rogers C. Neointimal thickening after stent delivery of paclitaxel: change in composition and arrest of growth over six months. J Am Coll Cardiol. 2000 Dec; 36(7):2325-32.
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  147. Welt FG, Edelman ER, Simon DI, Rogers C. Neutrophil, not macrophage, infiltration precedes neointimal thickening in balloon-injured arteries. Arterioscler Thromb Vasc Biol. 2000 Dec; 20(12):2553-8.
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  148. Elmalak O, Lovich MA, Edelman E. Correlation of transarterial transport of various dextrans with their physicochemical properties. Biomaterials. 2000 Nov; 21(22):2263-72.
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  149. Edelman ER, Nathan A, Katada M, Gates J, Karnovsky MJ. Perivascular graft heparin delivery using biodegradable polymer wraps. Biomaterials. 2000 Nov; 21(22):2279-86.
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  150. Parikh SA, Edelman ER. Endothelial cell delivery for cardiovascular therapy. Adv Drug Deliv Rev. 2000 Aug 20; 42(1-2):139-61.
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  151. Ettenson DS, Koo EW, Januzzi JL, Edelman ER. Endothelial heparan sulfate is necessary but not sufficient for control of vascular smooth muscle cell growth. J Cell Physiol. 2000 Jul; 184(1):93-100.
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  152. Nugent MA, Nugent HM, Iozzo RV, Sanchack K, Edelman ER. Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia. Proc Natl Acad Sci U S A. 2000 Jun 6; 97(12):6722-7.
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  153. Tavakkolizadeh A, Shen R, Abraham P, Kormi N, Seifert P, Edelman ER, Jacobs DO, Zinner MJ, Ashley SW, Whang EE. Glucagon-like peptide 2: a new treatment for chemotherapy-induced enteritis. J Surg Res. 2000 Jun 1; 91(1):77-82.
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  154. Creel CJ, Lovich MA, Edelman ER. Arterial paclitaxel distribution and deposition. Circ Res. 2000 Apr 28; 86(8):879-84.
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  155. Garasic JM, Edelman ER, Squire JC, Seifert P, Williams MS, Rogers C. Stent and artery geometry determine intimal thickening independent of arterial injury. Circulation. 2000 Feb 22; 101(7):812-8.
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  156. Simon DI, Dhen Z, Seifert P, Edelman ER, Ballantyne CM, Rogers C. Decreased neointimal formation in Mac-1(-/-) mice reveals a role for inflammation in vascular repair after angioplasty. J Clin Invest. 2000 Feb; 105(3):293-300.
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  157. Noh I, Lovich MA, Edelman ER. Mechanisms of heparin transport through expanded poly(tetrafluoroethylene) vascular grafts. J Biomed Mater Res. 2000 Jan; 49(1):112-9.
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  158. Ettenson DS, Edelman ER. Local drug delivery: an emerging approach in the treatment of restenosis. Vasc Med. 2000; 5(2):97-102.
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  159. Edelman ER. Vascular tissue engineering : designer arteries. Circ Res. 1999 Dec 3-17; 85(12):1115-7.
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  160. Laham RJ, Sellke FW, Edelman ER, Pearlman JD, Ware JA, Brown DL, Gold JP, Simons M. Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery: results of a phase I randomized, double-blind, placebo-controlled trial. Circulation. 1999 Nov 2; 100(18):1865-71.
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  161. Squire JC, Rogers C, Edelman ER. Measuring arterial strain induced by endovascular stents. Med Biol Eng Comput. 1999 Nov; 37(6):692-8.
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  162. Lovich MA, Edelman ER. Tissue concentration of heparin, not administered dose, correlates with the biological response of injured arteries in vivo. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11111-6.
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  163. Edelman ER, Rogers C. Stent-versus-stent equivalency trials : are some stents more equal than others? Circulation. 1999 Aug 31; 100(9):896-8.
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  164. Wan WK, Lovich MA, Hwang CW, Edelman ER. Measurement of drug distribution in vascular tissue using quantitative fluorescence microscopy. J Pharm Sci. 1999 Aug; 88(8):822-9.
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  165. Nugent HM, Rogers C, Edelman ER. Endothelial implants inhibit intimal hyperplasia after porcine angioplasty. Circ Res. 1999 Mar 5; 84(4):384-91.
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  166. Rogers C, Tseng DY, Squire JC, Edelman ER. Balloon-artery interactions during stent placement: a finite element analysis approach to pressure, compliance, and stent design as contributors to vascular injury. Circ Res. 1999 Mar 5; 84(4):378-83.
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  167. Lovich MA, Philbrook M, Sawyer S, Weselcouch E, Edelman ER. Arterial heparin deposition: role of diffusion, convection, and extravascular space. Am J Physiol. 1998 Dec; 275(6 Pt 2):H2236-42.
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  168. Yu C, Cunningham M, Rogers C, Dinbergs ID, Edelman ER. The biologic effects of growth factor-toxin conjugates in models of vascular injury depend on dose, mode of delivery, and animal species. J Pharm Sci. 1998 Nov; 87(11):1300-4.
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  169. Tseng DY, Edelman ER. Effects of amide and amine plasma-treated ePTFE vascular grafts on endothelial cell lining in an artificial circulatory system. J Biomed Mater Res. 1998 Nov; 42(2):188-98.
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  170. Raman VK, Edelman ER. Coated stents: local pharmacology. Semin Interv Cardiol. 1998 Sep-Dec; 3(3-4):133-7.
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  171. Rogers C, Edelman ER, Simon DI. A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10134-9.
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  172. Sellke FW, Laham RJ, Edelman ER, Pearlman JD, Simons M. Therapeutic angiogenesis with basic fibroblast growth factor: technique and early results. Ann Thorac Surg. 1998 Jun; 65(6):1540-4.
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  173. Edelman ER, Rogers C. Pathobiologic responses to stenting. Am J Cardiol. 1998 Apr 9; 81(7A):4E-6E.
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  174. Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Prasad P, Thomas KA, DiSalvo J, Caputo RP, Carrozza JP, Douglas PS, Sellke FW, Simons M. Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia. Am J Physiol. 1998 Mar; 274(3 Pt 2):H930-6.
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  175. Edelman ER. Vessel size, antioxidants, and restenosis: never too small, not too little, but often too late. Circulation. 1998 Feb 10; 97(5):416-20.
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  176. Edelman ER, Lovich M. Drug delivery models transported to a new level. Nat Biotechnol. 1998 Feb; 16(2):136-7.
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  177. Kjelsberg MA, Seifert P, Edelman ER, Rogers C. Design-Dependent Variations in Coronary Stent Stenosis Measured as Precisely by Angiography as by Histology. J Invasive Cardiol. 1998 Apr; 10(3):142-150.
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  178. Han RO, Ettenson DS, Koo EW, Edelman ER. Heparin/heparan sulfate chelation inhibits control of vascular repair by tissue-engineered endothelial cells. Am J Physiol. 1997 Dec; 273(6 Pt 2):H2586-95.
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  179. Sirois MG, Simons M, Kuter DJ, Rosenberg RD, Edelman ER. Rat arterial wall retains myointimal hyperplastic potential long after arterial injury. Circulation. 1997 Aug 19; 96(4):1291-8.
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  180. Lopez JJ, Edelman ER, Stamler A, Hibberd MG, Prasad P, Caputo RP, Carrozza JP, Douglas PS, Sellke FW, Simons M. Basic fibroblast growth factor in a porcine model of chronic myocardial ischemia: a comparison of angiographic, echocardiographic and coronary flow parameters. J Pharmacol Exp Ther. 1997 Jul; 282(1):385-90.
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  181. D'Orléans-Juste P, Sirois MG, Edelman ER, Regoli D, Pheng LH, Bkaily G, Lindsey CJ. DNA antisense strategies in the study of receptors for vasoactive peptides, and of growth and wound-healing factors. Mol Cell Biochem. 1997 Jul; 172(1-2):199-211.
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  182. Lovich MA, Brown L, Edelman ER. Drug clearance and arterial uptake after local perivascular delivery to the rat carotid artery. J Am Coll Cardiol. 1997 Jun; 29(7):1645-50.
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  183. Sirois MG, Edelman ER. VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor. Am J Physiol. 1997 Jun; 272(6 Pt 2):H2746-56.
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  184. Kozarsky KF, Donahee MH, Rigotti A, Iqbal SN, Edelman ER, Krieger M. Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels. Nature. 1997 May 22; 387(6631):414-7.
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  185. Welt FG, Edelman ER. Second International Symposium on Cardiovascular Drug Delivery. Circulation. 1997 Feb 18; 95(4):773-6.
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  186. Sirois MG, Simons M, Edelman ER. Antisense oligonucleotide inhibition of PDGFR-beta receptor subunit expression directs suppression of intimal thickening. Circulation. 1997 Feb 4; 95(3):669-76.
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  187. Rigotti A, Edelman ER, Seifert P, Iqbal SN, DeMattos RB, Temel RE, Krieger M, Williams DL. Regulation by adrenocorticotropic hormone of the in vivo expression of scavenger receptor class B type I (SR-BI), a high density lipoprotein receptor, in steroidogenic cells of the murine adrenal gland. J Biol Chem. 1996 Dec 27; 271(52):33545-9.
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  188. Rogers C, Parikh S, Seifert P, Edelman ER. Endogenous cell seeding. Remnant endothelium after stenting enhances vascular repair. Circulation. 1996 Dec 1; 94(11):2909-14.
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  189. Brown LR, Edelman ER, Fischel-Ghodsian F, Langer R. Characterization of glucose-mediated insulin release from implantable polymers. J Pharm Sci. 1996 Dec; 85(12):1341-5.
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  190. Edelman ER, Brown L, Langer R. Quantification of insulin release from implantable polymer-based delivery systems and augmentation of therapeutic effect with simultaneous release of somatostatin. J Pharm Sci. 1996 Dec; 85(12):1271-5.
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  191. Dinbergs ID, Brown L, Edelman ER. Cellular response to transforming growth factor-beta1 and basic fibroblast growth factor depends on release kinetics and extracellular matrix interactions. J Biol Chem. 1996 Nov 22; 271(47):29822-9.
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  192. Lovich MA, Edelman ER. Computational simulations of local vascular heparin deposition and distribution. Am J Physiol. 1996 Nov; 271(5 Pt 2):H2014-24.
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  193. Rogers C, Welt FG, Karnovsky MJ, Edelman ER. Monocyte recruitment and neointimal hyperplasia in rabbits. Coupled inhibitory effects of heparin. Arterioscler Thromb Vasc Biol. 1996 Oct; 16(10):1312-8.
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  194. Edelman ER, Rogers C. Hoop dreams. Stents without restenosis. Circulation. 1996 Sep 15; 94(6):1199-202.
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  195. Lopez JJ, Edelman ER, Stamler A, Morgan JP, Sellke FW, Simons M. Local perivascular administration of basic fibroblast growth factor: drug delivery and toxicological evaluation. Drug Metab Dispos. 1996 Aug; 24(8):922-4.
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  196. Harada K, Friedman M, Lopez JJ, Wang SY, Li J, Prasad PV, Pearlman JD, Edelman ER, Sellke FW, Simons M. Vascular endothelial growth factor administration in chronic myocardial ischemia. Am J Physiol. 1996 May; 270(5 Pt 2):H1791-802.
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  197. Lovich MA, Edelman ER. Tissue average binding and equilibrium distribution: an example with heparin in arterial tissues. Biophys J. 1996 Mar; 70(3):1553-9.
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  198. Simons M, Rosenberg RD, Edelman ER. . . . and surreal antisense? Nat Med. 1996 Feb; 2(2):131-2.
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  199. Lovich MA, Edelman ER. Mechanisms of transmural heparin transport in the rat abdominal aorta after local vascular delivery. Circ Res. 1995 Dec; 77(6):1143-50.
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  200. Prausnitz MR, Edelman ER, Gimm JA, Langer R, Weaver JC. Transdermal delivery of heparin by skin electroporation. Biotechnology (N Y). 1995 Nov; 13(11):1205-9.
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  201. Nathan A, Nugent MA, Edelman ER. Tissue engineered perivascular endothelial cell implants regulate vascular injury. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8130-4.
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  202. Rogers C, Edelman ER. Endovascular stent design dictates experimental restenosis and thrombosis. Circulation. 1995 Jun 15; 91(12):2995-3001.
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  203. Edelman ER, Simons M, Sirois MG, Rosenberg RD. c-myc in vasculoproliferative disease. Circ Res. 1995 Feb; 76(2):176-82.
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  204. Sellke FW, Wang SY, Friedman M, Harada K, Edelman ER, Grossman W, Simons M. Basic FGF enhances endothelium-dependent relaxation of the collateral-perfused coronary microcirculation. Am J Physiol. 1994 Oct; 267(4 Pt 2):H1303-11.
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  205. Harada K, Grossman W, Friedman M, Edelman ER, Prasad PV, Keighley CS, Manning WJ, Sellke FW, Simons M. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts. J Clin Invest. 1994 Aug; 94(2):623-30.
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  206. Simons M, Edelman ER, Rosenberg RD. Antisense proliferating cell nuclear antigen oligonucleotides inhibit intimal hyperplasia in a rat carotid artery injury model. J Clin Invest. 1994 Jun; 93(6):2351-6.
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  207. Rabbani LE, Edelman ER, Ganz P, Selwyn AP, Loscalzo J, Bittl JA. Relation of restenosis after excimer laser angioplasty to fasting insulin levels. Am J Cardiol. 1994 Feb 15; 73(5):323-7.
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  208. Edelman ER, Karnovsky MJ. Contrasting effects of the intermittent and continuous administration of heparin in experimental restenosis. Circulation. 1994 Feb; 89(2):770-6.
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  209. Nugent MA, Karnovsky MJ, Edelman ER. Vascular cell-derived heparan sulfate shows coupled inhibition of basic fibroblast growth factor binding and mitogenesis in vascular smooth muscle cells. Circ Res. 1993 Dec; 73(6):1051-60.
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  210. Rogers C, Karnovsky MJ, Edelman ER. Inhibition of experimental neointimal hyperplasia and thrombosis depends on the type of vascular injury and the site of drug administration. Circulation. 1993 Sep; 88(3):1215-21.
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  211. Edelman ER, Langer R. Optimization of release from magnetically controlled polymeric drug release devices. Biomaterials. 1993 Jul; 14(8):621-6.
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  212. Wolfe MW, Edelman ER. Transient systolic dysfunction after relief of cardiac tamponade. Ann Intern Med. 1993 Jul 1; 119(1):42-4.
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  213. Edelman ER, Pukac LA, Karnovsky MJ. Protamine and protamine-insulins exacerbate the vascular response to injury. J Clin Invest. 1993 May; 91(5):2308-13.
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  214. Edelman ER, Nugent MA, Karnovsky MJ. Perivascular and intravenous administration of basic fibroblast growth factor: vascular and solid organ deposition. Proc Natl Acad Sci U S A. 1993 Feb 15; 90(4):1513-7.
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  215. Edelman ER, Fiorino A, Grodzinsky A, Langer R. Mechanical deformation of polymer matrix controlled release devices modulates drug release. J Biomed Mater Res. 1992 Dec; 26(12):1619-31.
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  216. Nugent MA, Edelman ER. Transforming growth factor beta 1 stimulates the production of basic fibroblast growth factor binding proteoglycans in Balb/c3T3 cells. J Biol Chem. 1992 Oct 15; 267(29):21256-64.
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  217. Nugent MA, Edelman ER. Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: a mechanism for cooperactivity. Biochemistry. 1992 Sep 22; 31(37):8876-83.
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  218. Simons M, Edelman ER, DeKeyser JL, Langer R, Rosenberg RD. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature. 1992 Sep 3; 359(6390):67-70.
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  219. Edelman ER, Stuenkel CA, Rutherford JD, Williams GH. Diabetic ketoacidosis associated with pheochromocytoma. Cleve Clin J Med. 1992 Jul-Aug; 59(4):423-7.
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  220. Edelman ER, Nugent MA, Smith LT, Karnovsky MJ. Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat arteries. J Clin Invest. 1992 Feb; 89(2):465-73.
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  221. Edelman ER, Mathiowitz E, Langer R, Klagsbrun M. Controlled and modulated release of basic fibroblast growth factor. Biomaterials. 1991 Sep; 12(7):619-26.
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  222. Tofler GH, Stone PH, Maclure M, Edelman E, Davis VG, Robertson T, Antman EM, Muller JE. Analysis of possible triggers of acute myocardial infarction (the MILIS study). Am J Cardiol. 1990 Jul 1; 66(1):22-7.
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  223. Edelman ER, Adams DH, Karnovsky MJ. Effect of controlled adventitial heparin delivery on smooth muscle cell proliferation following endothelial injury. Proc Natl Acad Sci U S A. 1990 May; 87(10):3773-7.
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  224. Friedman PL, Selwyn AP, Edelman E, Wang PJ. Effect of selective intracoronary antiarrhythmic drug administration in sustained ventricular tachycardia. Am J Cardiol. 1989 Sep 1; 64(8):475-80.
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  225. Muller JE, Tofler GH, Edelman E. Probable triggers of onset of acute myocardial infarction. Clin Cardiol. 1989 Aug; 12(8):473-5.
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  226. Klagsbrun M, Edelman ER. Biological and biochemical properties of fibroblast growth factors. Implications for the pathogenesis of atherosclerosis. Arteriosclerosis. 1989 May-Jun; 9(3):269-78.
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  227. Edelman ER, Brown L, Taylor J, Langer R. In vitro and in vivo kinetics of regulated drug release from polymer matrices by oscillating magnetic fields. J Biomed Mater Res. 1987 Mar; 21(3):339-53.
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  228. Brown L, Munoz C, Siemer L, Edelman E, Langer R. Controlled release of insulin from polymer matrices. Control of diabetes in rats. Diabetes. 1986 Jun; 35(6):692-7.
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  229. Langer R, Brown L, Edelman E. Controlled release and magnetically modulated release systems for macromolecules. Methods Enzymol. 1985; 112:399-422.
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  230. Langer R, Siegel R, Brown L, Leong K, Kost J, Edelman E. Controlled release and magnetically modulated systems for macromolecular drugs. Ann N Y Acad Sci. 1985; 446:1-13.
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  231. Edelman ER, Kost J, Bobeck H, Langer R. Regulation of drug release from polymer matrices by oscillating magnetic fields. J Biomed Mater Res. 1985 Jan; 19(1):67-83.
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  232. Edelman ER, Brown L, Kost J, Taylor J, Langer R. Modulated release from polymeric drug delivery systems using oscillating magnetic fields: in vitro and in vivo characteristics. Trans Am Soc Artif Intern Organs. 1984; 30:445-9.
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