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Bruce A. Yankner, M.D.,Ph.D.

TitleProfessor of Genetics
InstitutionHarvard Medical School
DepartmentGenetics
AddressHarvard Medical School
Dept. of Genetics, NRB-858C
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-6800
Fax617/432-6825
Other Positions
TitleProfessor of Neurology
InstitutionChildren's Hospital Boston
DepartmentNeurology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B, Shi Y. The histone demethylase LSD1/KDM1A promotes the DNA damage response. J Cell Biol. 2013 Nov 11; 203(3):457-70.
    View in: PubMed
  2. Gabuzda D, Yankner BA. Physiology: Inflammation links ageing to the brain. Nature. 2013 May 9; 497(7448):197-8.
    View in: PubMed
  3. Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JW. Altered social behavior and neuronal development in mice lacking the uba6-use1 ubiquitin transfer system. Mol Cell. 2013 Apr 25; 50(2):172-84.
    View in: PubMed
  4. Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z. Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature. 2011 Dec 15; 480(7377):372-5.
    View in: PubMed
  5. Haigis MC, Yankner BA. The aging stress response. Mol Cell. 2010 Oct 22; 40(2):333-44.
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  6. Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, Yuan J. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14164-9.
    View in: PubMed
  7. Furuya T, Kim M, Lipinski M, Li J, Kim D, Lu T, Shen Y, Rameh L, Yankner B, Tsai LH, Yuan J. Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell. 2010 May 28; 38(4):500-11.
    View in: PubMed
  8. Bishop NA, Lu T, Yankner BA. Neural mechanisms of ageing and cognitive decline. Nature. 2010 Mar 25; 464(7288):529-35.
    View in: PubMed
  9. Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell. 2008 Nov 28; 135(5):907-18.
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  10. Yankner BA, Lu T. Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem. 2009 Feb 20; 284(8):4755-9.
    View in: PubMed
  11. Loerch PM, Lu T, Dakin KA, Vann JM, Isaacs A, Geula C, Wang J, Pan Y, Gabuzda DH, Li C, Prolla TA, Yankner BA. Evolution of the aging brain transcriptome and synaptic regulation. PLoS One. 2008; 3(10):e3329.
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  12. Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, Hardingham GE. Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci. 2008 Apr; 11(4):476-87.
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  13. Yankner BA, Lu T, Loerch P. The aging brain. Annu Rev Pathol. 2008; 3:41-66.
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  14. Isaacs AM, Senn DB, Yuan M, Shine JP, Yankner BA. Acceleration of amyloid beta-peptide aggregation by physiological concentrations of calcium. J Biol Chem. 2006 Sep 22; 281(38):27916-23.
    View in: PubMed
  15. Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem. 2006 May 19; 281(20):14474-85.
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  16. Hass MR, Yankner BA. A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J Biol Chem. 2005 Nov 4; 280(44):36895-904.
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  17. Xu J, Zhong N, Wang H, Elias JE, Kim CY, Woldman I, Pifl C, Gygi SP, Geula C, Yankner BA. The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum Mol Genet. 2005 May 1; 14(9):1231-41.
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  18. Lu T, Pan Y, Kao SY, Li C, Kohane I, Chan J, Yankner BA. Gene regulation and DNA damage in the ageing human brain. Nature. 2004 Jun 24; 429(6994):883-91.
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  19. Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P. Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. J Biol Chem. 2003 May 30; 278(22):19974-9.
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  20. Xu J, Kao SY, Lee FJ, Song W, Jin LW, Yankner BA. Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease. Nat Med. 2002 Jun; 8(6):600-6.
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  21. Ebinu JO, Yankner BA. A RIP tide in neuronal signal transduction. Neuron. 2002 May 16; 34(4):499-502.
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  22. Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA. Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron. 2002 Feb 28; 33(5):677-88.
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  23. Weninger SC, Yankner BA. Inflammation and Alzheimer disease: the good, the bad, and the ugly. Nat Med. 2001 May; 7(5):527-8.
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  24. Yuan J, Yankner BA. Apoptosis in the nervous system. Nature. 2000 Oct 12; 407(6805):802-9.
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  25. Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, Yankner BA. Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1. Nat Cell Biol. 2000 Jul; 2(7):463-5.
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  26. Lorenzo A, Yuan M, Zhang Z, Paganetti PA, Sturchler-Pierrat C, Staufenbiel M, Mautino J, Vigo FS, Sommer B, Yankner BA. Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nat Neurosci. 2000 May; 3(5):460-4.
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  27. Yankner BA. A century of cognitive decline. Nature. 2000 Mar 9; 404(6774):125.
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  28. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature. 2000 Jan 6; 403(6765):98-103.
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  29. Yankner BA. The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end? Ann N Y Acad Sci. 2000; 924:26-8.
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  30. Hartmann H, Yankner BA. Normal proteolytic processing of the presenilins. Methods Mol Med. 2000; 32:297-308.
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  31. Song W, Nadeau P, Yuan M, Yang X, Shen J, Yankner BA. Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci U S A. 1999 Jun 8; 96(12):6959-63.
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  32. Yuan J, Yankner BA. Caspase activity sows the seeds of neuronal death. Nat Cell Biol. 1999 Jun; 1(2):E44-5.
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  33. Liu C, Kato Y, Zhang Z, Do VM, Yankner BA, He X. beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6273-8.
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  34. Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature. 1998 Oct 15; 395(6703):698-702.
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  35. Geula C, Wu CK, Saroff D, Lorenzo A, Yuan M, Yankner BA. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat Med. 1998 Jul; 4(7):827-31.
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  36. Yankner BA. Monster plaques: what they tell us about Alzheimer's disease. Nat Med. 1998 Apr; 4(4):394-5.
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  37. Busciglio J, Hartmann H, Lorenzo A, Wong C, Baumann K, Sommer B, Staufenbiel M, Yankner BA. Neuronal localization of presenilin-1 and association with amyloid plaques and neurofibrillary tangles in Alzheimer's disease. J Neurosci. 1997 Jul 1; 17(13):5101-7.
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  38. Hartmann H, Busciglio J, Baumann KH, Staufenbiel M, Yankner BA. Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation. J Biol Chem. 1997 Jun 6; 272(23):14505-8.
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  39. Baumann K, Paganetti PA, Sturchler-Pierrat C, Wong C, Hartmann H, Cescato R, Frey P, Yankner BA, Sommer B, Staufenbiel M. Distinct processing of endogenous and overexpressed recombinant presenilin 1. Neurobiol Aging. 1997 Mar-Apr; 18(2):181-9.
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  40. Yankner BA. New clues to Alzheimer's disease: unraveling the roles of amyloid and tau. Nat Med. 1996 Aug; 2(8):850-2.
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  41. Yankner BA. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron. 1996 May; 16(5):921-32.
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  42. Lorenzo A, Yankner BA. Amyloid fibril toxicity in Alzheimer's disease and diabetes. Ann N Y Acad Sci. 1996 Jan 17; 777:89-95.
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  43. Busciglio J, Yankner BA. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature. 1995 Dec 21-28; 378(6559):776-9.
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  44. Martin BL, Schrader-Fischer G, Busciglio J, Duke M, Paganetti P, Yankner BA. Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein. J Biol Chem. 1995 Nov 10; 270(45):26727-30.
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  45. Busciglio J, Lorenzo A, Yeh J, Yankner BA. beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron. 1995 Apr; 14(4):879-88.
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  46. Lorenzo A, Yankner BA. Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci U S A. 1994 Dec 6; 91(25):12243-7.
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  47. Gabuzda D, Busciglio J, Chen LB, Matsudaira P, Yankner BA. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem. 1994 May 6; 269(18):13623-8.
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  48. Lorenzo A, Razzaboni B, Weir GC, Yankner BA. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature. 1994 Apr 21; 368(6473):756-60.
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  49. Gabuzda D, Busciglio J, Yankner BA. Inhibition of beta-amyloid production by activation of protein kinase C. J Neurochem. 1993 Dec; 61(6):2326-9.
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  50. Busciglio J, Yeh J, Yankner BA. beta-Amyloid neurotoxicity in human cortical culture is not mediated by excitotoxins. J Neurochem. 1993 Oct; 61(4):1565-8.
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  51. Busciglio J, Gabuzda DH, Matsudaira P, Yankner BA. Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells. Proc Natl Acad Sci U S A. 1993 Mar 1; 90(5):2092-6.
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  52. Yankner BA. Commentary and perspective on studies of beta amyloid neurotoxicity. Neurobiol Aging. 1992 Sep-Oct; 13(5):615-6.
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  53. Busciglio J, Lorenzo A, Yankner BA. Methodological variables in the assessment of beta amyloid neurotoxicity. Neurobiol Aging. 1992 Sep-Oct; 13(5):609-12.
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  54. Kowall NW, McKee AC, Yankner BA, Beal MF. In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment. Neurobiol Aging. 1992 Sep-Oct; 13(5):537-42.
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  55. Chen M, Tempst P, Yankner BA. Secretogranin I/chromogranin B is a heparin-binding adhesive protein. J Neurochem. 1992 May; 58(5):1691-8.
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  56. Yankner BA, Mesulam MM. Seminars in medicine of the Beth Israel Hospital, Boston. beta-Amyloid and the pathogenesis of Alzheimer's disease. N Engl J Med. 1991 Dec 26; 325(26):1849-57.
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  57. Kowall NW, Beal MF, Busciglio J, Duffy LK, Yankner BA. An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7247-51.
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  58. Chen M, Yankner BA. An antibody to beta amyloid and the amyloid precursor protein inhibits cell-substratum adhesion in many mammalian cell types. Neurosci Lett. 1991 Apr 29; 125(2):223-6.
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  59. Yankner BA, Caceres A, Duffy LK. Nerve growth factor potentiates the neurotoxicity of beta amyloid. Proc Natl Acad Sci U S A. 1990 Nov; 87(22):9020-3.
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  60. Yankner BA, Duffy LK, Kirschner DA. Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science. 1990 Oct 12; 250(4978):279-82.
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  61. Neve RL, Dawes LR, Yankner BA, Benowitz LI, Rodriguez W, Higgins GA. Genetics and biology of the Alzheimer amyloid precursor. Prog Brain Res. 1990; 86:257-67.
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  62. Yankner BA, Benowitz LI, Villa-Komaroff L, Neve RL. Transfection of PC12 cells with the human GAP-43 gene: effects on neurite outgrowth and regeneration. Brain Res Mol Brain Res. 1990 Jan; 7(1):39-44.
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  63. Yankner BA. NGF and Alzheimer's disease--considerations and caveats. Neurobiol Aging. 1989 Sep-Oct; 10(5):546-7; discussion 552-3.
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  64. Yankner BA. Amyloid and Alzheimer's disease--cause or effect? Neurobiol Aging. 1989 Sep-Oct; 10(5):470-1; discussion 477-8.
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  65. Yankner BA, Dawes LR, Fisher S, Villa-Komaroff L, Oster-Granite ML, Neve RL. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science. 1989 Jul 28; 245(4916):417-20.
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  66. Yankner BA, Skolnik PR, Shoukimas GM, Gabuzda DH, Sobel RA, Ho DD. Cerebral granulomatous angiitis associated with isolation of human T-lymphotropic virus type III from the central nervous system. Ann Neurol. 1986 Sep; 20(3):362-4.
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  67. Yankner BA, Shooter EM. The biology and mechanism of action of nerve growth factor. Annu Rev Biochem. 1982; 51:845-68.
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  68. Shooter EM, Yankner BA, Landreth GE, Sutter A. Biosynthesis and mechanism of action of nerve growth factor. Recent Prog Horm Res. 1981; 37:417-46.
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  69. Yankner BA, Shooter EM. Nerve growth factor in the nucleus: interaction with receptors on the nuclear membrane. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1269-73.
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