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Junying Yuan, PH.D.

TitleProfessor of Cell Biology
InstitutionHarvard Medical School
DepartmentCell Biology
AddressHarvard Medical School
Cell Biology
240 Longwood Ave
Boston MA 02115
Phone617/432-4170
Fax617/432-4177

 Mentoring 
 completed student projects
Elucidating the Role of PIPHD34, A Novel Murine PhD Zinc Finger-Containing Protein, in the Regulationof Apoptosis
Summer, 06/20/01 - 08/31/01
Role of PIPHD34, A Novel Murine PHD Zinc Protein, in the Regulation of Apoptosis
Part Time/Continuation, 09/20/01 - 06/01/02

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hitomi J, Christofferson DE, Ng A, Yao J, Degterev A, Xavier RJ, Yuan J. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell. 2008 Dec 26; 135(7):1311-23.
    View in: PubMed
  2. Bryant KF, Macari ER, Malik N, Boyce M, Yuan J, Coen DM. ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. Virology. 2008 Sep 30; 379(2):197-204.
    View in: PubMed
  3. Zhu J, Blenis J, Yuan J. Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. Proc Natl Acad Sci U S A. 2008 May 6; 105(18):6584-9.
    View in: PubMed
  4. Teng X, Keys H, Yuan J, Degterev A, Cuny GD. Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors. Bioorg Med Chem Lett. 2008 Jun 1; 18(11):3219-23.
    View in: PubMed
  5. Li J, Yin HL, Yuan J. Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity. J Cell Biol. 2008 Apr 21; 181(2):321-33.
    View in: PubMed
  6. Yuan J. Inducing autophagy harmlessly. Autophagy. 2008 Feb; 4(2):249-50.
    View in: PubMed
  7. Xu L, Zhu J, Hu X, Zhu H, Kim HT, LaBaer J, Goldberg A, Yuan J. c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. Mol Cell. 2007 Dec 14; 28(5):914-22.
    View in: PubMed
  8. Sanchez-Olea R, Yuan J. To kill or to arrest: that is the new question for Apaf-1. Mol Cell. 2007 Nov 30; 28(4):520-1.
    View in: PubMed
  9. Yi CH, Sogah DK, Boyce M, Degterev A, Christofferson DE, Yuan J. A genome-wide RNAi screen reveals multiple regulators of caspase activation. J Cell Biol. 2007 Nov 19; 179(4):619-26.
    View in: PubMed
  10. Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6836-40.
    View in: PubMed
  11. Py BF, Lipinski MM, Yuan J. Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infection. Autophagy. 2007 Mar-Apr; 3(2):117-25.
    View in: PubMed
  12. Jagtap PG, Degterev A, Choi S, Keys H, Yuan J, Cuny GD. Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem. 2007 Apr 19; 50(8):1886-95.
    View in: PubMed
  13. Li J, Brieher WM, Scimone ML, Kang SJ, Zhu H, Yin H, von Andrian UH, Mitchison T, Yuan J. Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization. Nat Cell Biol. 2007 Mar; 9(3):276-86.
    View in: PubMed
  14. Zhang Y, Zhou X, Degterev A, Lipinski M, Adjeroh D, Yuan J, Wong ST. Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays. Neuroimage. 2007 May 1; 35(4):1502-15.
    View in: PubMed
  15. Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 2007 Jan 26; 128(2):257-67.
    View in: PubMed
  16. Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev. 2007 Jan 1; 21(1):98-111.
    View in: PubMed
  17. Zhang Y, Zhou X, Degterev A, Lipinski M, Adjeroh D, Yuan J, Wong ST. A novel tracing algorithm for high throughput imaging Screening of neuron-based assays. J Neurosci Methods. 2007 Feb 15; 160(1):149-62.
    View in: PubMed
  18. Yuan J. Divergence from a dedicated cellular suicide mechanism: exploring the evolution of cell death. Mol Cell. 2006 Jul 7; 23(1):1-12.
    View in: PubMed
  19. Matsui T, Ramasamy K, Ingelsson M, Fukumoto H, Conrad C, Frosch MP, Irizarry MC, Yuan J, Hyman BT. Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels. J Neuropathol Exp Neurol. 2006 May; 65(5):508-15.
    View in: PubMed
  20. Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J. Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1. J Biol Chem. 2006 May 19; 281(20):14474-85.
    View in: PubMed
  21. Yoo LI, Liu DW, Le Vu S, Bronson RT, Wu H, Yuan J. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner. Cancer Res. 2006 Feb 15; 66(4):1929-39.
    View in: PubMed
  22. Teng X, Degterev A, Jagtap P, Xing X, Choi S, Denu R, Yuan J, Cuny GD. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15; 15(22):5039-44.
    View in: PubMed
  23. Lipinski MM, Yuan J. A cellular response to an internal energy crisis. Cell. 2005 Oct 7; 123(1):3-5.
    View in: PubMed
  24. Gozani O, Field SJ, Ferguson CG, Ewalt M, Mahlke C, Cantley LC, Prestwich GD, Yuan J. Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms. Adv Enzyme Regul. 2005; 45:171-85.
    View in: PubMed
  25. Elkin SK, Ivanov D, Ewalt M, Ferguson CG, Hyberts SG, Sun ZY, Prestwich GD, Yuan J, Wagner G, Oettinger MA, Gozani OP. A PHD finger motif in the C terminus of RAG2 modulates recombination activity. J Biol Chem. 2005 Aug 5; 280(31):28701-10.
    View in: PubMed
  26. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul; 1(2):112-9.
    View in: PubMed
  27. Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science. 2005 Feb 11; 307(5711):935-9.
    View in: PubMed
  28. Kang SJ, Popat R, Bragdon C, Odonnell K, Phelan S, Yuan J, Sonis ST. Caspase-11 is not necessary for chemotherapy-induced intestinal mucositis. DNA Cell Biol. 2004 Aug; 23(8):490-5.
    View in: PubMed
  29. Terui Y, Saad N, Jia S, McKeon F, Yuan J. Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1. J Biol Chem. 2004 Jul 2; 279(27):28257-65.
    View in: PubMed
  30. Qiu XB, Markant SL, Yuan J, Goldberg AL. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J. 2004 Feb 25; 23(4):800-10.
    View in: PubMed
  31. Lipinski MM, Yuan J. Mechanisms of cell death in polyglutamine expansion diseases. Curr Opin Pharmacol. 2004 Feb; 4(1):85-90.
    View in: PubMed
  32. Yuan J, Horvitz HR. A first insight into the molecular mechanisms of apoptosis. Cell. 2004 Jan 23; 116(2 Suppl):S53-6, 1 p following S59.
    View in: PubMed
  33. Degterev A, Boyce M, Yuan J. A decade of caspases. Oncogene. 2003 Nov 24; 22(53):8543-67.
    View in: PubMed
  34. Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death. Neuron. 2003 Oct 9; 40(2):401-13.
    View in: PubMed
  35. Welch K, Yuan J. Alpha-synuclein oligomerization: a role for lipids? Trends Neurosci. 2003 Oct; 26(10):517-9.
    View in: PubMed
  36. Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 2003 Jul 11; 114(1):99-111.
    View in: PubMed
  37. Zong WX, Li C, Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, Thompson CB. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol. 2003 Jul 7; 162(1):59-69.
    View in: PubMed
  38. Kang SJ, Sanchez I, Jing N, Yuan J. Dissociation between neurodegeneration and caspase-11-mediated activation of caspase-1 and caspase-3 in a mouse model of amyotrophic lateral sclerosis. J Neurosci. 2003 Jul 2; 23(13):5455-60.
    View in: PubMed
  39. Sánchez I, Mahlke C, Yuan J. Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders. Nature. 2003 Jan 23; 421(6921):373-9.
    View in: PubMed
  40. Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology. 2003 Jan; 144(1):69-74.
    View in: PubMed
  41. Le DA, Wu Y, Huang Z, Matsushita K, Plesnila N, Augustinack JC, Hyman BT, Yuan J, Kuida K, Flavell RA, Moskowitz MA. Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):15188-93.
    View in: PubMed
  42. Yoo LI, Chung DC, Yuan J. LKB1--a master tumour suppressor of the small intestine and beyond. Nat Rev Cancer. 2002 Jul; 2(7):529-35.
    View in: PubMed
  43. Welch K, Yuan J. Releasing the nerve cell killers. Nat Med. 2002 Jun; 8(6):564-5.
    View in: PubMed
  44. Gozani O, Boyce M, Yoo L, Karuman P, Yuan J. Life and death in paradise. Nat Cell Biol. 2002 Jun; 4(6):E159-62.
    View in: PubMed
  45. Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D'Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. J Neurosci. 2002 May 15; 22(10):4015-24.
    View in: PubMed
  46. Qiu J, Whalen MJ, Lowenstein P, Fiskum G, Fahy B, Darwish R, Aarabi B, Yuan J, Moskowitz MA. Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans. J Neurosci. 2002 May 1; 22(9):3504-11.
    View in: PubMed
  47. Lugovskoy AA, Degterev AI, Fahmy AF, Zhou P, Gross JD, Yuan J, Wagner G. A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors. J Am Chem Soc. 2002 Feb 20; 124(7):1234-40.
    View in: PubMed
  48. Yuan J, Yankner BA. Apoptosis in the nervous system. Nature. 2000 Oct 12; 407(6805):802-9.
    View in: PubMed
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