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Philip Leder, M.D.

TitleJohn Emory Andrus Professor of Genetics, Emeritus
InstitutionHarvard Medical School
DepartmentEmeritus
AddressHarvard Medical School
Genetics NRB Room 356
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-7667
Fax617/432-7944

 Mentoring 
 completed student projects

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Leder P. Retrospective. Marshall Warren Nirenberg (1927-2010). Science. 2010 Feb 19; 327(5968):972.
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  2. Ravi D, Wiles AM, Bhavani S, Ruan J, Leder P, Bishop AJ. A network of conserved damage survival pathways revealed by a genomic RNAi screen. PLoS Genet. 2009 Jun; 5(6):e1000527.
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  3. Zhou F, Leder P, Zuniga A, Dettenhofer M. Formin1 disruption confers oligodactylism and alters Bmp signaling. Hum Mol Genet. 2009 Jul 1; 18(13):2472-82.
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  4. Babbe H, McMenamin J, Hobeika E, Wang J, Rodig SJ, Reth M, Leder P. Genomic instability resulting from Blm deficiency compromises development, maintenance, and function of the B cell lineage. J Immunol. 2009 Jan 1; 182(1):347-60.
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  5. Li X, Ito M, Zhou F, Youngson N, Zuo X, Leder P, Ferguson-Smith AC. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev Cell. 2008 Oct; 15(4):547-57.
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  6. Dettenhofer M, Zhou F, Leder P. Formin 1-isoform IV deficient cells exhibit defects in cell spreading and focal adhesion formation. PLoS One. 2008; 3(6):e2497.
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  7. Leder A, McMenamin J, Zhou F, Moran JL, Beier DR, Leder P. Genome-wide SNP analysis of Tg.AC transgenic mice reveals an oncogenic collaboration between v-Ha-ras and Ink4a, which is absent in p53 deficiency. Oncogene. 2008 Apr 10; 27(17):2456-65.
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  8. Li X, Leder P. Identifying genes preferentially expressed in undifferentiated embryonic stem cells. BMC Cell Biol. 2007; 8:37.
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  9. Lu J, Ruhf ML, Perrimon N, Leder P. A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9381-6.
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  10. Babbe H, Chester N, Leder P, Reizis B. The Bloom's syndrome helicase is critical for development and function of the alphabeta T-cell lineage. Mol Cell Biol. 2007 Mar; 27(5):1947-59.
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  11. Chester N, Babbe H, Pinkas J, Manning C, Leder P. Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Mol Cell Biol. 2006 Sep; 26(17):6713-26.
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  12. Fantin VR, Leder P. Mitochondriotoxic compounds for cancer therapy. Oncogene. 2006 Aug 7; 25(34):4787-97.
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  13. Fantin VR, St-Pierre J, Leder P. Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell. 2006 Jun; 9(6):425-34.
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  14. Zhou F, Leder P, Martin SS. Formin-1 protein associates with microtubules through a peptide domain encoded by exon-2. Exp Cell Res. 2006 Apr 15; 312(7):1119-26.
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  15. Ridgeway AG, McMenamin J, Leder P. P53 levels determine outcome during beta-catenin tumor initiation and metastasis in the mammary gland and male germ cells. Oncogene. 2006 Jun 15; 25(25):3518-27.
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  16. Fantin VR, Berardi MJ, Babbe H, Michelman MV, Manning CM, Leder P. A bifunctional targeted peptide that blocks HER-2 tyrosine kinase and disables mitochondrial function in HER-2-positive carcinoma cells. Cancer Res. 2005 Aug 1; 65(15):6891-900.
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  17. Leder A, McMenamin J, Fontaine K, Bishop A, Leder P. zeta-/- Thalassemic mice are affected by two modifying loci and display unanticipated somatic recombination leading to inherited variation. Hum Mol Genet. 2005 Mar 1; 14(5):615-25.
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  18. Leder P. The formins: connecting embryonic pattern formation and hypofertility in the mouse. Ann N Y Acad Sci. 2004 Dec; 1038:75-9.
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  19. Pinkas J, Martin SS, Leder P. Bcl-2-mediated cell survival promotes metastasis of EpH4 betaMEKDD mammary epithelial cells. Mol Cancer Res. 2004 Oct; 2(10):551-6.
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  20. Shigematsu H, Reizis B, Iwasaki H, Mizuno S, Hu D, Traver D, Leder P, Sakaguchi N, Akashi K. Plasmacytoid dendritic cells activate lymphoid-specific genetic programs irrespective of their cellular origin. Immunity. 2004 Jul; 21(1):43-53.
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  21. Martin SS, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS, Leder P. A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene. 2004 Jun 3; 23(26):4641-5.
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  22. Fantin VR, Leder P. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1; 64(1):329-36.
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  23. McDaniel LD, Chester N, Watson M, Borowsky AD, Leder P, Schultz RA. Chromosome instability and tumor predisposition inversely correlate with BLM protein levels. DNA Repair (Amst). 2003 Dec 9; 2(12):1387-404.
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  24. Ecsedy JA, Michaelson JS, Leder P. Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol Cell Biol. 2003 Feb; 23(3):950-60.
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  25. Weiss RS, Leder P, Vaziri C. Critical role for mouse Hus1 in an S-phase DNA damage cell cycle checkpoint. Mol Cell Biol. 2003 Feb; 23(3):791-803.
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  26. Michaelson JS, Leder P. RNAi reveals anti-apoptotic and transcriptionally repressive activities of DAXX. J Cell Sci. 2003 Jan 15; 116(Pt 2):345-52.
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  27. Leader B, Lim H, Carabatsos MJ, Harrington A, Ecsedy J, Pellman D, Maas R, Leder P. Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. Nat Cell Biol. 2002 Dec; 4(12):921-8.
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  28. Leder A, Lebel M, Zhou F, Fontaine K, Bishop A, Leder P. Genetic interaction between the unstable v-Ha-RAS transgene (Tg.AC) and the murine Werner syndrome gene: transgene instability and tumorigenesis. Oncogene. 2002 Sep 26; 21(43):6657-68.
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  29. Pinkas J, Leder P. MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition. Cancer Res. 2002 Aug 15; 62(16):4781-90.
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  30. Fantin VR, Berardi MJ, Scorrano L, Korsmeyer SJ, Leder P. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul; 2(1):29-42.
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  31. Gounari F, Aifantis I, Martin C, Fehling HJ, Hoeflinger S, Leder P, von Boehmer H, Reizis B. Tracing lymphopoiesis with the aid of a pTalpha-controlled reporter gene. Nat Immunol. 2002 May; 3(5):489-96.
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  32. Reizis B, Leder P. Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev. 2002 Feb 1; 16(3):295-300.
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  33. Weiss RS, Matsuoka S, Elledge SJ, Leder P. Hus1 acts upstream of chk1 in a mammalian DNA damage response pathway. Curr Biol. 2002 Jan 8; 12(1):73-7.
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  34. Vollrath B, Pudney J, Asa S, Leder P, Fitzgerald K. Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland. Mol Cell Biol. 2001 Nov; 21(21):7481-94.
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  35. Reizis B, Leder P. The upstream enhancer is necessary and sufficient for the expression of the pre-T cell receptor alpha gene in immature T lymphocytes. J Exp Med. 2001 Oct 1; 194(7):979-90.
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  36. Martin SS, Leder P. Human MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2. Mol Cell Biol. 2001 Oct; 21(19):6529-36.
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  37. Michaelson JS, Leder P. beta-catenin is a downstream effector of Wnt-mediated tumorigenesis in the mammary gland. Oncogene. 2001 Aug 23; 20(37):5093-9.
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  38. Vollrath B, Fitzgerald KJ, Leder P. A murine homologue of the Drosophila brainiac gene shows homology to glycosyltransferases and is required for preimplantation development of the mouse. Mol Cell Biol. 2001 Aug; 21(16):5688-97.
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  39. Goodwin NC, Ishida Y, Hartford S, Wnek C, Bergstrom RA, Leder P, Schimenti JC. DelBank: a mouse ES-cell resource for generating deletions. Nat Genet. 2001 Aug; 28(4):310-1.
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  40. Brodie SG, Xu X, Li C, Kuo A, Leder P, Deng CX. Inactivation of p53 tumor suppressor gene acts synergistically with c-neu oncogene in salivary gland tumorigenesis. Oncogene. 2001 Mar 22; 20(12):1445-54.
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  41. Lebel M, Cardiff RD, Leder P. Tumorigenic effect of nonfunctional p53 or p21 in mice mutant in the Werner syndrome helicase. Cancer Res. 2001 Mar 1; 61(5):1816-9.
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  42. Fitzgerald K, Harrington A, Leder P. Ras pathway signals are required for notch-mediated oncogenesis. Oncogene. 2000 Aug 31; 19(37):4191-8.
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  43. Lane TF, Lin C, Brown MA, Solomon E, Leder P. Gene replacement with the human BRCA1 locus: tissue specific expression and rescue of embryonic lethality in mice. Oncogene. 2000 Aug 24; 19(36):4085-90.
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  44. Weiss RS, Enoch T, Leder P. Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress. Genes Dev. 2000 Aug 1; 14(15):1886-98.
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  45. Weinstein EJ, Leder P. The extracellular region of heregulin is sufficient to promote mammary gland proliferation and tumorigenesis but not apoptosis. Cancer Res. 2000 Jul 15; 60(14):3856-61.
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  46. Bedford MT, Frankel A, Yaffe MB, Clarke S, Leder P, Richard S. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. J Biol Chem. 2000 May 26; 275(21):16030-6.
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  47. Leader B, Leder P. Formin-2, a novel formin homology protein of the cappuccino subfamily, is highly expressed in the developing and adult central nervous system. Mech Dev. 2000 May; 93(1-2):221-31.
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  48. Bedford MT, Sarbassova D, Xu J, Leder P, Yaffe MB. A novel pro-Arg motif recognized by WW domains. J Biol Chem. 2000 Apr 7; 275(14):10359-69.
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  49. Chodosh LA, Gardner HP, Rajan JV, Stairs DB, Marquis ST, Leder PA. Protein kinase expression during murine mammary development. Dev Biol. 2000 Mar 15; 219(2):259-76.
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  50. Weiss RS, Leder P, Enoch T. A conserved role for the Hus1 checkpoint protein in eukaryotic genome maintenance. Cold Spring Harb Symp Quant Biol. 2000; 65:457-66.
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  51. Reizis B, Lee JT, Leder P. Homologous genomic fragments in the mouse pre-T cell receptor alpha (pTa) and Xist loci. Genomics. 2000 Jan 1; 63(1):149-52.
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  52. Weinstein EJ, Kitsberg DI, Leder P. A mouse model for breast cancer induced by amplification and overexpression of the neu promoter and transgene. Mol Med. 2000 Jan; 6(1):4-16.
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  53. Lebel M, Spillare EA, Harris CC, Leder P. The Werner syndrome gene product co-purifies with the DNA replication complex and interacts with PCNA and topoisomerase I. J Biol Chem. 1999 Dec 31; 274(53):37795-9.
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  54. Ishida Y, Leder P. RET: a poly A-trap retrovirus vector for reversible disruption and expression monitoring of genes in living cells. Nucleic Acids Res. 1999 Dec 15; 27(24):e35.
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  55. Michaelson JS, Bader D, Kuo F, Kozak C, Leder P. Loss of Daxx, a promiscuously interacting protein, results in extensive apoptosis in early mouse development. Genes Dev. 1999 Aug 1; 13(15):1918-23.
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  56. Weiss RS, Kostrub CF, Enoch T, Leder P. Mouse Hus1, a homolog of the Schizosaccharomyces pombe hus1+ cell cycle checkpoint gene. Genomics. 1999 Jul 1; 59(1):32-9.
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  57. Bedford MT, Leder P. The FF domain: a novel motif that often accompanies WW domains. Trends Biochem Sci. 1999 Jul; 24(7):264-5.
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  58. Leder A, Wiener E, Lee MJ, Wickramasinghe SN, Leder P. A normal beta-globin allele as a modifier gene ameliorating the severity of alpha-thalassemia in mice. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6291-5.
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  59. Reizis B, Leder P. Expression of the mouse pre-T cell receptor alpha gene is controlled by an upstream region containing a transcriptional enhancer. J Exp Med. 1999 May 17; 189(10):1669-78.
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  60. Westphal CH, Muller L, Zhou A, Zhu X, Bonner-Weir S, Schambelan M, Steiner DF, Lindberg I, Leder P. The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease. Cell. 1999 Mar 5; 96(5):689-700.
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  61. Chen H, Leder P. A new signal sequence trap using alkaline phosphatase as a reporter. Nucleic Acids Res. 1999 Feb 15; 27(4):1219-22.
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  62. Westphal CH, Hoyes KP, Canman CE, Huang X, Kastan MB, Hendry JH, Leder P. Loss of atm radiosensitizes multiple p53 null tissues. Cancer Res. 1998 Dec 15; 58(24):5637-9.
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  63. Chester N, Kuo F, Kozak C, O'Hara CD, Leder P. Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene. Genes Dev. 1998 Nov 1; 12(21):3382-93.
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  64. Lebel M, Leder P. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13097-102.
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  65. Weinstein EJ, Grimm S, Leder P. The oncogene heregulin induces apoptosis in breast epithelial cells and tumors. Oncogene. 1998 Oct 22; 17(16):2107-13.
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  66. Grimm S, Weinstein EJ, Krane IM, Leder P. Neu differentiation factor (NDF), a dominant oncogene, causes apoptosis in vitro and in vivo. J Exp Med. 1998 Oct 19; 188(8):1535-9.
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  67. Chao CW, Chan DC, Kuo A, Leder P. The mouse formin (Fmn) gene: abundant circular RNA transcripts and gene-targeted deletion analysis. Mol Med. 1998 Sep; 4(9):614-28.
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  68. Bedford MT, Reed R, Leder P. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Proc Natl Acad Sci U S A. 1998 Sep 1; 95(18):10602-7.
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  69. Kelliher MA, Grimm S, Ishida Y, Kuo F, Stanger BZ, Leder P. The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity. 1998 Mar; 8(3):297-303.
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  70. Amundadottir LT, Leder P. Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes. Oncogene. 1998 Feb 12; 16(6):737-46.
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  71. Xu X, Weinstein M, Li C, Naski M, Cohen RI, Ornitz DM, Leder P, Deng C. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development. 1998 Feb; 125(4):753-65.
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  72. Wang YA, Elson A, Leder P. Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14590-5.
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  73. Lane TF, Leder P. Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice. Oncogene. 1997 Oct; 15(18):2133-44.
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  74. Leder A, Daugherty C, Whitney B, Leder P. Mouse zeta- and alpha-globin genes: embryonic survival, alpha-thalassemia, and genetic background effects. Blood. 1997 Aug 1; 90(3):1275-82.
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  75. Westphal CH, Rowan S, Schmaltz C, Elson A, Fisher DE, Leder P. atm and p53 cooperate in apoptosis and suppression of tumorigenesis, but not in resistance to acute radiation toxicity. Nat Genet. 1997 Aug; 16(4):397-401.
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  76. Westphal CH, Leder P. Transposon-generated 'knock-out' and 'knock-in' gene-targeting constructs for use in mice. Curr Biol. 1997 Jul 1; 7(7):530-3.
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  77. Wynshaw-Boris A, Ryan G, Deng CX, Chan DC, Jackson-Grusby L, Larson D, Dunmore JH, Leder P. The role of a single formin isoform in the limb and renal phenotypes of limb deformity. Mol Med. 1997 Jun; 3(6):372-84.
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  78. Deng C, Bedford M, Li C, Xu X, Yang X, Dunmore J, Leder P. Fibroblast growth factor receptor-1 (FGFR-1) is essential for normal neural tube and limb development. Dev Biol. 1997 May 1; 185(1):42-54.
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  79. Westphal CH, Schmaltz C, Rowan S, Elson A, Fisher DE, Leder P. Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints. Cancer Res. 1997 May 1; 57(9):1664-7.
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  80. Bedford MT, Chan DC, Leder P. FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. EMBO J. 1997 May 1; 16(9):2376-83.
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  81. Grimm S, Leder P. An apoptosis-inducing isoform of neu differentiation factor (NDF) identified using a novel screen for dominant, apoptosis-inducing genes. J Exp Med. 1997 Mar 17; 185(6):1137-42.
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  82. Rothenberg ME, MacLean JA, Pearlman E, Luster AD, Leder P. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia. J Exp Med. 1997 Feb 17; 185(4):785-90.
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  83. Wang CC, Chan DC, Leder P. The mouse formin (Fmn) gene: genomic structure, novel exons, and genetic mapping. Genomics. 1997 Feb 1; 39(3):303-11.
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  84. Shen MM, Wang H, Leder P. A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation. Development. 1997 Jan; 124(2):429-42.
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  85. Kitsberg DI, Leder P. Keratinocyte growth factor induces mammary and prostatic hyperplasia and mammary adenocarcinoma in transgenic mice. Oncogene. 1996 Dec 19; 13(12):2507-15.
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  86. Elson A, Wang Y, Daugherty CJ, Morton CC, Zhou F, Campos-Torres J, Leder P. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13084-9.
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  87. Grimm S, Stanger BZ, Leder P. RIP and FADD: two "death domain"-containing proteins can induce apoptosis by convergent, but dissociable, pathways. Proc Natl Acad Sci U S A. 1996 Oct 1; 93(20):10923-7.
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  88. Kelliher MA, Seldin DC, Leder P. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha. EMBO J. 1996 Oct 1; 15(19):5160-6.
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  89. Chan DC, Leder P. Genetic evidence that formins function within the nucleus. J Biol Chem. 1996 Sep 20; 271(38):23472-7.
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  90. Rothenberg ME, Ownbey R, Mehlhop PD, Loiselle PM, van de Rijn M, Bonventre JV, Oettgen HC, Leder P, Luster AD. Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. Mol Med. 1996 May; 2(3):334-48.
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  91. Krane IM, Leder P. NDF/heregulin induces persistence of terminal end buds and adenocarcinomas in the mammary glands of transgenic mice. Oncogene. 1996 Apr 18; 12(8):1781-8.
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  92. Garcia-Zepeda EA, Rothenberg ME, Ownbey RT, Celestin J, Leder P, Luster AD. Human eotaxin is a specific chemoattractant for eosinophil cells and provides a new mechanism to explain tissue eosinophilia. Nat Med. 1996 Apr; 2(4):449-56.
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  93. Deng C, Wynshaw-Boris A, Zhou F, Kuo A, Leder P. Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell. 1996 Mar 22; 84(6):911-21.
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  94. Chan DC, Bedford MT, Leder P. Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J. 1996 Mar 1; 15(5):1045-54.
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  95. Elson A, Kozak CA, Morton CC, Weremowicz S, Leder P. The protein tyrosine phosphatase epsilon gene maps to mouse chromosome 7 and human chromosome 10q26. Genomics. 1996 Feb 1; 31(3):373-5.
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  96. Vogt TF, Leder P. Polydactyly in the Strong's luxoid mouse is suppressed by limb deformity alleles. Dev Genet. 1996; 19(1):33-42.
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  97. Elson A, Leder P. Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12235-9.
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  98. Elson A, Leder P. Protein-tyrosine phosphatase epsilon. An isoform specifically expressed in mouse mammary tumors initiated by v-Ha-ras OR neu. J Biol Chem. 1995 Nov 3; 270(44):26116-22.
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  99. Lane TF, Deng C, Elson A, Lyu MS, Kozak CA, Leder P. Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev. 1995 Nov 1; 9(21):2712-22.
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  100. Chan DC, Wynshaw-Boris A, Leder P. Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud. Development. 1995 Oct; 121(10):3151-62.
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  101. Rothenberg ME, Luster AD, Leder P. Murine eotaxin: an eosinophil chemoattractant inducible in endothelial cells and in interleukin 4-induced tumor suppression. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8960-4.
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  102. Deng C, Zhang P, Harper JW, Elledge SJ, Leder P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 1995 Aug 25; 82(4):675-84.
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  103. Elson A, Deng C, Campos-Torres J, Donehower LA, Leder P. The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice. Oncogene. 1995 Jul 6; 11(1):181-90.
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  104. Luster AD, Greenberg SM, Leder P. The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation. J Exp Med. 1995 Jul 1; 182(1):219-31.
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  105. Chan DC, Laufer E, Tabin C, Leder P. Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity. Development. 1995 Jul; 121(7):1971-8.
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  106. Stanger BZ, Leder P, Lee TH, Kim E, Seed B. RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell. 1995 May 19; 81(4):513-23.
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  107. Chaillet JR, Bader DS, Leder P. Regulation of genomic imprinting by gametic and embryonic processes. Genes Dev. 1995 May 15; 9(10):1177-87.
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  108. Skoda RC, Tsai SF, Orkin SH, Leder P. Expression of c-MYC under the control of GATA-1 regulatory sequences causes erythroleukemia in transgenic mice. J Exp Med. 1995 May 1; 181(5):1603-13.
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  109. Lee FS, Lane TF, Kuo A, Shackleford GM, Leder P. Insertional mutagenesis identifies a member of the Wnt gene family as a candidate oncogene in the mammary epithelium of int-2/Fgf-3 transgenic mice. Proc Natl Acad Sci U S A. 1995 Mar 14; 92(6):2268-72.
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  110. Rich BE, Leder P. Transgenic expression of interleukin 7 restores T cell populations in nude mice. J Exp Med. 1995 Mar 1; 181(3):1223-8.
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  111. Rothenberg ME, Luster AD, Lilly CM, Drazen JM, Leder P. Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. J Exp Med. 1995 Mar 1; 181(3):1211-6.
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  112. Seldin DC, Leder P. Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle. Science. 1995 Feb 10; 267(5199):894-7.
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  113. Morrison BW, Moorman JR, Kowdley GC, Kobayashi YM, Jones LR, Leder P. Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes. J Biol Chem. 1995 Feb 3; 270(5):2176-82.
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  114. Deng CX, Wynshaw-Boris A, Shen MM, Daugherty C, Ornitz DM, Leder P. Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev. 1994 Dec 15; 8(24):3045-57.
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  115. Morrison BW, Leder P. neu and ras initiate murine mammary tumors that share genetic markers generally absent in c-myc and int-2-initiated tumors. Oncogene. 1994 Dec; 9(12):3417-26.
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  116. Oettgen HC, Martin TR, Wynshaw-Boris A, Deng C, Drazen JM, Leder P. Active anaphylaxis in IgE-deficient mice. Nature. 1994 Aug 4; 370(6488):367-70.
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  117. Shen MM, Skoda RC, Cardiff RD, Campos-Torres J, Leder P, Ornitz DM. Expression of LIF in transgenic mice results in altered thymic epithelium and apparent interconversion of thymic and lymph node morphologies. EMBO J. 1994 Mar 15; 13(6):1375-85.
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  118. Seldin DC, Leder P. Mutational analysis of a critical signaling domain of the human interleukin 4 receptor. Proc Natl Acad Sci U S A. 1994 Mar 15; 91(6):2140-4.
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  119. Luster AD, Leder P. IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med. 1993 Sep 1; 178(3):1057-65.
    View in: PubMed
  120. Skoda RC, Seldin DC, Chiang MK, Peichel CL, Vogt TF, Leder P. Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J. 1993 Jul; 12(7):2645-53.
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  129. Shen MM, Leder P. Leukemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vitro. Proc Natl Acad Sci U S A. 1992 Sep 1; 89(17):8240-4.
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  132. Morrison BW, Leder P. A receptor binding domain of mouse interleukin-4 defined by a solid-phase binding assay and in vitro mutagenesis. J Biol Chem. 1992 Jun 15; 267(17):11957-63.
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  135. Kwan H, Pecenka V, Tsukamoto A, Parslow TG, Guzman R, Lin TP, Muller WJ, Lee FS, Leder P, Varmus HE. Transgenes expressing the Wnt-1 and int-2 proto-oncogenes cooperate during mammary carcinogenesis in doubly transgenic mice. Mol Cell Biol. 1992 Jan; 12(1):147-54.
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  142. Beier DR, Chaillet JR, Schmidt EV, Leder P. Close linkage of a transgene insertion site to the steel (Sl) locus on mouse chromosome 10. Genomics. 1991 Aug; 10(4):1003-8.
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  144. Baetscher M, Schmidt E, Shimizu A, Leder P, Fishman MC. SV40 T antigen transforms calcitonin cells of the thyroid but not CGRP-containing neurons in transgenic mice. Oncogene. 1991 Jul; 6(7):1133-8.
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  145. Mitchell RN, Shaw AC, Weaver YK, Leder P, Abbas AK. Cytoplasmic tail deletion converts membrane immunoglobulin to a phosphatidylinositol-linked form lacking signaling and efficient antigen internalization functions. J Biol Chem. 1991 May 15; 266(14):8856-60.
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  147. Flanagan JG, Chan DC, Leder P. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. Cell. 1991 Mar 8; 64(5):1025-35.
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  148. Yayon A, Klagsbrun M, Esko JD, Leder P, Ornitz DM. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. Cell. 1991 Feb 22; 64(4):841-8.
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  152. Huang E, Nocka K, Beier DR, Chu TY, Buck J, Lahm HW, Wellner D, Leder P, Besmer P. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell. 1990 Oct 5; 63(1):225-33.
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  157. Tepper RI, Levinson DA, Stanger BZ, Campos-Torres J, Abbas AK, Leder P. IL-4 induces allergic-like inflammatory disease and alters T cell development in transgenic mice. Cell. 1990 Aug 10; 62(3):457-67.
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  158. Schmidt EV, Christoph G, Zeller R, Leder P. The cytomegalovirus enhancer: a pan-active control element in transgenic mice. Mol Cell Biol. 1990 Aug; 10(8):4406-11.
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  159. Vasicek TJ, Leder P. Structure and expression of the human immunoglobulin lambda genes. J Exp Med. 1990 Aug 1; 172(2):609-20.
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  164. Shimizu A, Nussenzweig MC, Mizuta TR, Leder P, Honjo T. Immunoglobulin double-isotype expression by trans-mRNA in a human immunoglobulin transgenic mouse. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):8020-3.
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  165. Pattengale PK, Stewart TA, Leder A, Sinn E, Muller W, Tepler I, Schmidt E, Leder P. Animal models of human disease. Pathology and molecular biology of spontaneous neoplasms occurring in transgenic mice carrying and expressing activated cellular oncogenes. Am J Pathol. 1989 Jul; 135(1):39-61.
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  167. Beier DR, Morton CC, Leder A, Wallace R, Leder P. Perinatal lethality (ple): a mutation caused by integration of a transgene into distal mouse chromosome 15. Genomics. 1989 May; 4(4):498-504.
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  168. Tepler I, Shimizu A, Leder P. The gene for the rat mast cell high affinity IgE receptor alpha chain. Structure and alternative mRNA splicing patterns. J Biol Chem. 1989 Apr 5; 264(10):5912-5.
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  169. Sarid J, Benfey PN, Leder P. The mast cell-specific expression of a protease gene, RMCP II, is regulated by an enhancer element that binds specifically to mast cell trans-acting factors. J Biol Chem. 1989 Jan 15; 264(2):1022-6.
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  171. Halazonetis TD, Georgopoulos K, Greenberg ME, Leder P. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell. 1988 Dec 2; 55(5):917-24.
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  173. Flanagan JG, Leder P. neu protooncogene fused to an immunoglobulin heavy chain gene requires immunoglobulin light chain for cell surface expression and oncogenic transformation. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):8057-61.
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  181. Swain JL, Stewart TA, Leder P. Parental legacy determines methylation and expression of an autosomal transgene: a molecular mechanism for parental imprinting. Cell. 1987 Aug 28; 50(5):719-27.
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  194. Berliner N, Duby AD, Morton CC, Leder P, Seidman JG. Detection of a frequent restriction fragment length polymorphism in the human T cell antigen receptor beta chain locus. A potential diagnostic tool. J Clin Invest. 1985 Sep; 76(3):1283-5.
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  195. Leder A, Weir L, Leder P. Characterization, expression, and evolution of the mouse embryonic zeta-globin gene. Mol Cell Biol. 1985 May; 5(5):1025-33.
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  200. Potter H, Weir L, Leder P. Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation. Proc Natl Acad Sci U S A. 1984 Nov; 81(22):7161-5.
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  206. Taub R, Kelly K, Battey J, Latt S, Lenoir GM, Tantravahi U, Tu Z, Leder P. A novel alteration in the structure of an activated c-myc gene in a variant t(2;8) Burkitt lymphoma. Cell. 1984 Jun; 37(2):511-20.
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  208. Hollis GF, Mitchell KF, Battey J, Potter H, Taub R, Lenoir GM, Leder P. A variant translocation places the lambda immunoglobulin genes 3' to the c-myc oncogene in Burkitt's lymphoma. Nature. 1984 Feb 23-29; 307(5953):752-5.
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  209. Morton CC, Taub R, Diamond A, Lane MA, Cooper GM, Leder P. Mapping of the human Blym-1 transforming gene activated in Burkitt lymphomas to chromosome 1. Science. 1984 Jan 13; 223(4632):173-5.
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  210. Bonner T, O'Brien SJ, Nash WG, Rapp UR, Morton CC, Leder P. The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4. Science. 1984 Jan 6; 223(4631):71-4.
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  218. Taub RA, Hollis GF, Hieter PA, Korsmeyer S, Waldmann TA, Leder P. Variable amplification of immunoglobulin lambda light-chain genes in human populations. Nature. 1983 Jul 14-20; 304(5922):172-4.
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  223. Korsmeyer SJ, Hieter PA, Sharrow SO, Goldman CK, Leder P, Waldmann TA. Normal human B cells display ordered light chain gene rearrangements and deletions. J Exp Med. 1982 Oct 1; 156(4):975-85.
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  226. Talkington CA, Leder P. Rescuing the in vitro function of a globin pseudogene promoter. Nature. 1982 Jul 8; 298(5870):192-5.
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  227. Max EE, Battey J, Ney R, Kirsch IR, Leder P. Duplication and deletion in the human immunoglobulin epsilon genes. Cell. 1982 Jun; 29(2):691-9.
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  233. Lueders K, Leder A, Leder P, Kuff E. Association between a transposed alpha-globin pseudogene and retrovirus-like elements in the BALB/c mouse genome. Nature. 1982 Feb 4; 295(5848):426-8.
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  236. Leder P, Konkel D, Leder A, Nishioka Y. Globin genes: a paradigm of gene structure, function, and evolution. Natl Cancer Inst Monogr. 1982; 60:49-54.
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  239. Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P. Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes. Cell. 1981 Dec; 27(3 Pt 2):583-91.
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  240. Korsmeyer SJ, Hieter PA, Ravetch JV, Poplack DG, Waldmann TA, Leder P. Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proc Natl Acad Sci U S A. 1981 Nov; 78(11):7096-100.
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  241. Kirsch IR, Ravetch JV, Kwan SP, Max EE, Ney RL, Leder P. Multiple immunoglobulin switch region homologies outside the heavy chain constant region locus. Nature. 1981 Oct 15-21; 293(5833):585-7.
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  242. Kwan SP, Max EE, Seidman JG, Leder P, Scharff MD. Two kappa immunoglobulin genes are expressed in the myeloma S107. Cell. 1981 Oct; 26(1 Pt 1):57-66.
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  243. Leder A, Swan D, Ruddle F, D'Eustachio P, Leder P. Dispersion of alpha-like globin genes of the mouse to three different chromosomes. Nature. 1981 Sep 17-23; 293(5829):196-200.
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  244. Leder P. The structure of the beta-globin gene. JAMA. 1981 Jul 3; 246(1):75.
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  245. Max EE, Maizel JV, Leder P. The nucleotide sequence of a 5.5-kilobase DNA segment containing the mouse kappa immunoglobulin J and C region genes. J Biol Chem. 1981 May 25; 256(10):5116-20.
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  246. Kwan SP, Rudikoff S, Seidman JG, Leder P, Scharff MD. Nucleic acid and protein sequences of phosphocholine-binding light chains. J Exp Med. 1981 May 1; 153(5):1366-70.
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  247. Hieter PA, Korsmeyer SJ, Waldmann TA, Leder P. Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells. Nature. 1981 Apr 2; 290(5805):368-72.
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  248. Leder P, Max EE, Seidman JG, Kwan SP, Scharff M, Nau M, Norman B. Recombination events that activate, diversify, and delete immunoglobulin genes. Cold Spring Harb Symp Quant Biol. 1981; 45 Pt 2:859-65.
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  249. Leder P, Konkel DA, Nishiuoka Y, Leder A, Hamer DH, Kaehler M. The organization and evolution of cloned globin genes. Prog Clin Biol Res. 1981; 45:51-66.
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  250. Talkington CA, Nishioka Y, Leder P. In vitro transcription of normal, mutant, and truncated mouse alpha-globin genes. Proc Natl Acad Sci U S A. 1980 Dec; 77(12):7132-6.
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  251. Ravetch JV, Kirsch IR, Leder P. Evolutionary approach to the question of immunoglobulin heavy chain switching: evidence from cloned human and mouse genes. Proc Natl Acad Sci U S A. 1980 Nov; 77(11):6734-8.
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  252. Hieter PA, Max EE, Seidman JG, Maizel JV, Leder P. Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments. Cell. 1980 Nov; 22(1 Pt 1):197-207.
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  253. Hamer DH, Kaehler M, Leder P. A mouse globin gene promoter is functional in SV40. Cell. 1980 Oct; 21(3):697-708.
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  254. Max EE, Seidman JG, Miller H, Leder P. Variation in the crossover point of kappa immunoglobulin gene V-J recombination: evidence from a cryptic gene. Cell. 1980 Oct; 21(3):793-9.
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  255. Seidman JG, Nau MM, Norman B, Kwan SP, Scharff M, Leder P. Immunoglobulin V/J recombination is accompanied by deletion of joining site and variable region segments. Proc Natl Acad Sci U S A. 1980 Oct; 77(10):6022-6.
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  256. Leder P, Hansen JN, Konkel D, Leder A, Nishioka Y, Talkington C. Mouse globin system: a functional and evolutionary analysis. Science. 1980 Sep 19; 209(4463):1336-42.
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  257. Seidman JG, Leder P. A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events. Nature. 1980 Aug 21; 286(5775):779-83.
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  258. Nishioka Y, Leder A, Leder P. Unusual alpha-globin-like gene that has cleanly lost both globin intervening sequences. Proc Natl Acad Sci U S A. 1980 May; 77(5):2806-9.
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  259. Nishioka Y, Leder P. Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes. J Biol Chem. 1980 Apr 25; 255(8):3691-4.
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  260. Obata M, Yamawaki-Kataoka Y, Takahashi N, Kataoka T, Shimizu A, Mano Y, Seidman JG, Peterlin BM, Leder P, Honjo T. Immunoglobulin gamma 1 heavy chain gene: structural gene sequences cloned in a bacterial plasmid. Gene. 1980 Apr; 9(1-2):87-97.
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  261. Perry RP, Kelley DE, Coleclough C, Seidman JG, Leder P, Tonegawa S, Matthyssens G, Weigert M. Transcription of mouse kappa chain genes: implications for allelic exclusion. Proc Natl Acad Sci U S A. 1980 Apr; 77(4):1937-41.
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  262. Leder P. The organization and expression of cloned globin genes. Harvey Lect. 1980; 74:81-100.
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  263. Hamer DH, Leder P. Splicing and the formation of stable RNA. Cell. 1979 Dec; 18(4):1299-302.
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  264. Nishioka Y, Leder P. The complete sequence of a chromosomal mouse alpha--globin gene reveals elements conserved throughout vertebrate evolution. Cell. 1979 Nov; 18(3):875-82.
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  265. Konkel DA, Maizel JV, Leder P. The evolution and sequence comparison of two recently diverged mouse chromosomal beta--globin genes. Cell. 1979 Nov; 18(3):865-73.
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  266. Hamer DH, Leder P. Expression of the chromosomal mouse Beta maj-globin gene cloned in SV40. Nature. 1979 Sep 6; 281(5726):35-40.
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  267. Seidman JG, Max EE, Leder P. A kappa-immunoglobulin gene is formed by site-specific recombination without further somatic mutation. Nature. 1979 Aug 2; 280(5721):370-5.
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  268. Hamer DH, Smith KD, Boyer SH, Leder P. SV40 recombinants carrying rabbit beta-globin gene coding sequences. Cell. 1979 Jul; 17(3):725-35.
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  269. Max EE, Seidman JG, Leder P. Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene. Proc Natl Acad Sci U S A. 1979 Jul; 76(7):3450-4.
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  270. Hamer DH, Leder P. SV40 recombinants carrying a functional RNA splice junction and polyadenylation site from the chromosomal mouse beta maj globin gene. Cell. 1979 Jul; 17(3):737-47.
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  271. Leder A, Miller HI, Hamer DH, Seidman JG, Norman B, Sullivan M, Leder P. Comparison of cloned mouse alpha- and beta-globin genes: conservation of intervening sequence locations and extragenic homology. Proc Natl Acad Sci U S A. 1978 Dec; 75(12):6187-91.
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  272. Seidman JG, Leder P. The arrangement and rearrangement of antibody genes. Nature. 1978 Dec 21-28; 276(5690):790-5.
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  273. Konkel DA, Tilghman SM, Leder P. The sequence of the chromosomal mouse beta-globin major gene: homologies in capping, splicing and poly(A) sites. Cell. 1978 Dec; 15(4):1125-32.
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  274. Miller HI, Konkel DA, Leder P. An intervening sequence of the mouse beta-globin major gene shares extensive homology only with beta-globin genes. Nature. 1978 Oct 26; 275(5682):772-4.
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  275. Seidman JG, Leder A, Nau M, Norman B, Leder P. Antibody diversity. Science. 1978 Oct 6; 202(4363):11-7.
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  276. Polsky F, Edgell MH, Seidman JG, Leder P. High capacity gel preparative electrophoresis for purification of fragments of genomic DNA. Anal Biochem. 1978 Jul 1; 87(2):397-410.
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  277. Tiemeier DC, Tilghman SM, Polsky FI, Seidman JG, Leder A, Edgell MH, Leder P. A comparison of two cloned mouse beta-globin genes and their surrounding and intervening sequences. Cell. 1978 Jun; 14(2):237-45.
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  278. Leder P. Discontinuous genes. N Engl J Med. 1978 May 11; 298(19):1079-81.
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  279. Tilghman SM, Curtis PJ, Tiemeier DC, Leder P, Weissmann C. The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A. 1978 Mar; 75(3):1309-13.
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  280. Seidman JG, Edgell MH, Leder P. Immunoglobulin light-chain structural gene sequences cloned in a bacterial plasmid. Nature. 1978 Feb 9; 271(5645):582-5.
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  281. Tilghman SM, Tiemeier DC, Seidman JG, Peterlin BM, Sullivan M, Maizel JV, Leder P. Intervening sequence of DNA identified in the structural portion of a mouse beta-globin gene. Proc Natl Acad Sci U S A. 1978 Feb; 75(2):725-9.
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  282. Leder P, Tilghman SM, Tiemeier DC, Polsky FI, Seidman JG, Edgell MH, Enquist LW, Leder A, Norman B. The cloning of mouse globin and surrounding gene sequences in bacteriophage lambda. Cold Spring Harb Symp Quant Biol. 1978; 42 Pt 2:915-20.
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  283. Tilghman SM, Tiemeier DC, Polsky F, Edgell MH, Seidman JG, Leder A, Enquist LW, Norman B, Leder P. Cloning specific segments of the mammalian genome: bacteriophage lambda containing mouse globin and surrounding gene sequences. Proc Natl Acad Sci U S A. 1977 Oct; 74(10):4406-10.
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  284. Leder P, Tiemeier D, Enquist L. EK2 derivatives of bacteriophage lambda useful in the cloning of DNA from higher organisms: the lambdagtWES system. Science. 1977 Apr 8; 196(4286):175-7.
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  285. Tiemeier DC, Tilghman SM, Leder P. Purification and cloning of a mouse ribosomal gene fragment in coliphage lambda. Gene. 1977; 2(3-4):173-91.
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  286. Leder P, Honjo T, Seidman J, Swan D. Origin of immunoglobulin gene diversity: the evidence and a restriction-modification model. Cold Spring Harb Symp Quant Biol. 1977; 41 Pt 2:855-62.
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  287. Tiemer D, Enquist L, Leder P. Improved derivative of a phage lambda EK2 vector for cloning recombinant DNA. Nature. 1976 Oct 7; 263(5577):526-7.
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  288. Leder A, Orkin S, Leder P. Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis. Science. 1975 Nov 28; 190(4217):893-4.
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  289. Orkin SH, Swan D, Leder P. Differential expression of alpha- and beta-globin genes during differentiation of cultured erythroleukemic cells. J Biol Chem. 1975 Nov 25; 250(22):8753-60.
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  290. Leder A, Leder P. Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells. Cell. 1975 Jul; 5(3):319-22.
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  291. Orkin SH, Harosi FI, Leder P. Differentiation in erythroleukemic cells and their somatic hybrids. Proc Natl Acad Sci U S A. 1975 Jan; 72(1):98-102.
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  292. Ross J, Ikawa Y, Gielen J, Packman S, Leder P. Induction of globin mRNA in Friend leukemia virus-infected cells and its presence in viral 60S RNA. Bibl Haematol. 1975; (40):205-20.
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  293. Leder P, Honjo T, Packman S, Swan D, Nau M, Norman B. The organization and diversity of immunoglobulin genes. Proc Natl Acad Sci U S A. 1974 Dec; 71(12):5109-15.
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  294. Venetianer P, Leder P. Enzymatic synthesis of solid phase-bound DNA sequences corresponding to specific mammalian genes. Proc Natl Acad Sci U S A. 1974 Oct; 71(10):3892-5.
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  295. Honjo T, Packman S, Swan D, Nau M, Leder P. Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene. Proc Natl Acad Sci U S A. 1974 Sep; 71(9):3659-63.
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  296. Ross J, Gielen J, Packman S, Ikawa Y, Leder P. Globin gene expression in cultured erythroleukemic cells. J Mol Biol. 1974 Aug 25; 87(4):697-714.
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  297. Gielen J, Aviv H, Leder P. Characteristics of rabbit globin mRNA purification by oligo(dT) cellulose chromatography. Arch Biochem Biophys. 1974 Jul; 163(1):146-54.
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  298. Aviv H, Packman S, Ross J, Swan D, Gielen J, Leder P. DNA complementary to globin and immunoglobulin mRNA: a probe to study gene expression. Adv Exp Med Biol. 1974 Jun; 44(1):141-52.
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  299. Ikawa Y, Ross J, Leder P. An association between globin messenger RNA and 60S RNA derived from Friend leukemia virus. Proc Natl Acad Sci U S A. 1974 Apr; 71(4):1154-8.
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  300. Leder P, Ross J, Gielen J, Packman S, Ikawa Y, Aviv H, Swan D. Regulated expression of mammalian genes: globin and immunoglobulin as model systems. Cold Spring Harb Symp Quant Biol. 1974; 38:753-61.
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  301. Ross J, Aviv H, Leder P. Characterization of synthetic rabbit globin DNA. Arch Biochem Biophys. 1973 Oct; 158(2):494-502.
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  302. Aviv H, Packman S, Swan D, Ross J, Leder P. In vitro synthesis of DNA complementary to mRNA derived from a light chain-producing myeloma tumour. Nat New Biol. 1973 Feb 7; 241(110):174-6.
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  303. Boime I, Leder P. Protein synthesis directed by encephalomyocarditis virus mRNA. 3. Discrete polypeptides translated from a monocistronic messenger in vitro. Arch Biochem Biophys. 1972 Dec; 153(2):706-13.
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  304. Ross J, Ikawa Y, Leder P. Globin messenger-RNA induction during erythroid differentiation of cultured leukemia cells. Proc Natl Acad Sci U S A. 1972 Dec; 69(12):3620-3.
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  305. Callahan R, Leder P. In vitro initiation of coliphage T7 mRNA. Arch Biochem Biophys. 1972 Dec; 153(2):802-13.
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  306. Packman S, Aviv H, Ross J, Leder P. A comparison of globin genes in duck reticulocytes and liver cells. Biochem Biophys Res Commun. 1972 Nov 1; 49(3):813-9.
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  307. Aviv H, Leder P. Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose. Proc Natl Acad Sci U S A. 1972 Jun; 69(6):1408-12.
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  308. Ross J, Aviv H, Scolnick E, Leder P. In vitro synthesis of DNA complementary to purified rabbit globin mRNA (RNA-dependent DNA polymerase-reticulocyte-hemoglobin-density gradient centrifugation-oligo(dT) primer). Proc Natl Acad Sci U S A. 1972 Jan; 69(1):264-8.
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  309. Leder P, Bernardi A, Livingston D, Loyd B, Roufa D, Skogerson L. Protein biosynthesis: studies using synthetic and viral mRNAs. Cold Spring Harb Symp Quant Biol. 1969; 34:411-7.
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  310. Leder P, Bursztyn H. Initiation of protein synthesis: the role of formyl-accepting methionyl-tRNA. Cold Spring Harb Symp Quant Biol. 1966; 31:297-301.
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  311. LEDER P, NIRENBERG MW. RNA CODEWORDS AND PROTEIN SYNTHESIS, 3. ON THE NUCLEOTIDE SEQUENCE OF A CYSTEINE AND A LEUCINE RNA CODEWORD. Proc Natl Acad Sci U S A. 1964 Dec; 52:1521-9.
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