Simon Christopher Body, M.B.,CH.B.
|Title||Associate Professor of Anaesthesia|
|Institution||Brigham and Women's Hospital|
|Address||Brigham and Women's Hospital|
75 Francis St
Boston MA 02115
In 2000, I initiated and have led a program of examining the genetic influences upon adverse clinical outcomes after coronary artery bypass graft (CABG) surgery. Along with my co-investigators at BWH (Drs. Shernan, Fox, Muehlschlegel, Perry, Liu) and Texas Heart Institute (Dr. Collard) and collaborators at Duke and Vanderbilt we have spent the last eight years collecting over 2200 patients who have undergone primary CABG as the substrate for this research. We are examining the role of variation in candidate genes and their phenotypic expression on adverse postoperative outcomes, specifically atrial fibrillation, myocardial infarction, ventricular dysfunction and bleeding. This research is being funded by a grant from the Department of Anesthesiology, Perioperative and Pain Medicine Research Fund, previously by my K-23 grant from the NHLBI and up-coming R01 funding from NHLBI. In the last year, we have had papers specifically related to these areas published or accepted in Circulation:Cardiovascular Genetics, the Journal of Cardiothoracic and Vascular Surgery, Anesthesia and Analgesia, BMC Genetics and Anesthesiology.
In addition, along with colleagues at HMS (Drs. C. and J. Seidman), BWH ( Drs. Bolman, Shernan, and Tischler), MGH (Drs. Slaugenhaupt and Levine) I am researching the genetic causes of bicuspid aortic valve disease. We are collecting patients who have undergone or are undergoing surgery for BAV in order to derive associations between whole-genome exomal and genome variants and BAV.
Differential Gene Expression in Calcific Stenosis of Bicuspid and Tricuspid Aortic Valves
Summer, 06/11/12 - 08/17/12
Rotational Thromboelastometry to Predict Intraoperative and Postoperative
Bleeding in Cardiac Surgery
Summer, 06/20/11 - 08/12/11
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