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Rebecca Marlene Baron, M.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Pulmonary & Critical Care
75 Francis St
Boston MA 02115
Phone617/732-6987
Fax617/783-1813

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, Lawler LA, Christie JD, Meyer NJ, Causland FR, Waikar SS, Waxman AB, Chung RT, Bueno R, Rosas IO, Fredenburgh LE, Baron RM, Christiani DC, Hunninghake GM, Choi AM. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med. 2013 Dec; 10(12):e1001577.
    View in: PubMed
  2. Li Y, Dalli J, Chiang N, Baron RM, Quintana C, Serhan CN. Plasticity of Leukocytic Exudates in Resolving Acute Inflammation Is Regulated by MicroRNA and Proresolving Mediators. Immunity. 2013 Nov 14; 39(5):885-98.
    View in: PubMed
  3. Langley RJ, Tsalik EL, Velkinburgh JC, Glickman SW, Rice BJ, Wang C, Chen B, Carin L, Suarez A, Mohney RP, Freeman DH, Wang M, You J, Wulff J, Thompson JW, Moseley MA, Reisinger S, Edmonds BT, Grinnell B, Nelson DR, Dinwiddie DL, Miller NA, Saunders CJ, Soden SS, Rogers AJ, Gazourian L, Fredenburgh LE, Massaro AF, Baron RM, Choi AM, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore SF. An integrated clinico-metabolomic model improves prediction of death in sepsis. Sci Transl Med. 2013 Jul 24; 5(195):195ra95.
    View in: PubMed
  4. Lai PS, Hofmann O, Baron RM, Cernadas M, Meng QR, Bresler HS, Brass DM, Yang IV, Schwartz DA, Christiani DC, Hide W. Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin. PLoS One. 2013; 8(5):e62910.
    View in: PubMed
  5. Saha D, Takahashi K, de Prost N, Winkler T, Pinilla-Vera M, Baron RM, Vidal Melo MF. Micro-autoradiographic assessment of cell types contributing to 2-deoxy-2-[(18)f]fluoro-d-glucose uptake during ventilator-induced and endotoxemic lung injury. Mol Imaging Biol. 2013 Feb; 15(1):19-27.
    View in: PubMed
  6. Gazourian L, Coronata AM, Rogers AJ, Weinhouse GL, Soiffer RJ, Antin JH, Ritz J, Ho VT, Baron RM, Washko GR. Airway dilation in bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation. Respir Med. 2013 Feb; 107(2):276-83.
    View in: PubMed
  7. Manoli SE, Smith LA, Vyhlidal CA, An CH, Porrata Y, Cardoso WV, Baron RM, Haley KJ. Maternal smoking and the retinoid pathway in the developing lung. Respir Res. 2012; 13:42.
    View in: PubMed
  8. Sun X, Icli B, Wara AK, Belkin N, He S, Kobzik L, Hunninghake GM, Vera MP, Blackwell TS, Baron RM, Feinberg MW. MicroRNA-181b regulates NF-?B-mediated vascular inflammation. J Clin Invest. 2012 Jun 1; 122(6):1973-90.
    View in: PubMed
  9. Baron RM. Point: should coagulopathy be repaired prior to central venous line insertion? Yes: why take chances? Chest. 2012 May; 141(5):1139-42; discussion 1145-6.
    View in: PubMed
  10. Lai PS, Fresco JM, Pinilla MA, Macias AA, Brown RD, Englert JA, Hofmann O, Lederer JA, Hide W, Christiani DC, Cernadas M, Baron RM. Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):209-17.
    View in: PubMed
  11. Dolinay T, Kim YS, Howrylak J, Hunninghake GM, An CH, Fredenburgh L, Massaro AF, Rogers A, Gazourian L, Nakahira K, Haspel JA, Landazury R, Eppanapally S, Christie JD, Meyer NJ, Ware LB, Christiani DC, Ryter SW, Baron RM, Choi AM. Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med. 2012 Jun 1; 185(11):1225-34.
    View in: PubMed
  12. Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, Blumberg RS. Microbial exposure during early life has persistent effects on natural killer T cell function. Science. 2012 Apr 27; 336(6080):489-93.
    View in: PubMed
  13. Baron RM, Choi AJ, Owen CA, Choi AM. Genetically manipulated mouse models of lung disease: potential and pitfalls. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15; 302(6):L485-97.
    View in: PubMed
  14. Zhou X, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AM, Silverman EK. Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet. 2012 Mar 15; 21(6):1325-35.
    View in: PubMed
  15. Fredenburgh LE, Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, Chung SW, Liu X, Begay C, Padera RF, Blumberg RS, Walsh SR, Baron RM, Perrella MA. Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol. 2011 Nov 15; 187(10):5255-67.
    View in: PubMed
  16. Baron RM, Lopez-Guzman S, Riascos DF, Macias AA, Layne MD, Cheng G, Harris C, Chung SW, Reeves R, von Andrian UH, Perrella MA. Distamycin A inhibits HMGA1-binding to the P-selectin promoter and attenuates lung and liver inflammation during murine endotoxemia. PLoS One. 2010; 5(5):e10656.
    View in: PubMed
  17. Grant MA, Baron RM, Macias AA, Layne MD, Perrella MA, Rigby AC. Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter. Biochem J. 2009 Feb 15; 418(1):103-12.
    View in: PubMed
  18. Dolinay T, Baron RM, Fredenburgh L, Massaro AF, Lanazury R, Nakahira K, Choi AMK. Inflammasome Mediators Predict Disease Severity and Mortality in Patients with Sepsis and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2009; 179:A4646.
  19. JM Austin, JA Englert, RD Brown, B Ith, MA Perrella, DC Christiani, RM Baron. Modeling Physiologic Effects of Chronic Endotoxin Exposure in Mice [Oral presentation]. Am J Respir Crit Care Med. 2009; 179:A2189.
  20. JA Englert, L Dolgonos, DF Riascos, RM Baron. Increased NOS2 Expression in a Clinically-Relevant Murine Model of ARDS [Poster-Discussion] . Am J Respir Crit Care Med. 2009; 179:A3865.
  21. Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA. High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):129-35.
    View in: PubMed
  22. Takamiya R, Baron RM, Yet SF, Layne MD, Perrella MA. High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression. FEBS Lett. 2008 Mar 5; 582(5):810-4.
    View in: PubMed
  23. Baron RM, Perrella MA. Pathogenesis of Acute Lung Injury: Experimental Studies. Acute Respiratory Distress Syndrome, Editor: Augustine Choi. 2008.
  24. Chung SW, Liu X, Macias AA, Baron RM, Perrella MA. Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice. J Clin Invest. 2008 Jan; 118(1):239-47.
    View in: PubMed
  25. Englert JA, Baron RM. Sepsis Syndrome. Harvard Intensive Review of Internal Medicine. 2008.
  26. Baron RM, Riascos DF, Macias AA, Yet S-F, Layne MD, Perrella MA. Inhibition of HMGA1-DNA Binding in Mouse Vasculature Attenuates NOS2 Induction and Ameliorates Hypotension during Endotoxemia [Oral Presentation] . Proceedings of the American Thoracic Society. 2008.
  27. Baron BW, Zeleznik-Le N, Baron MJ, Theisler C, Huo D, Krasowski MD, Thirman MJ, Baron RM, Baron JM. Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas. Proc Natl Acad Sci U S A. 2007 May 1; 104(18):7449-54.
    View in: PubMed
  28. Marty FM, Lowry CM, Wilck M, Baron RM, Baden LR. Emergence of a clinical tigecycline-resistant mycobacterium abscessus during treatment of mycobacteremia and empyema after lung transplantation. ICAAC Meeting. 2006.
  29. Baron RM, Baron MJ, Perrella MA. Pathobiology of sepsis: are we still asking the same questions? Am J Respir Cell Mol Biol. 2006 Feb; 34(2):129-34.
    View in: PubMed
  30. Baron RM, Macias AA, Cheng G, von Andrian UH, Perrella MA. Minor Groove Binding Agents Attenuate Lung Inflammation, Modulate Neutrophil Adhesion, and Improve Outcomes during Murine Endotoxemia [abstract]. Proceedings of the American Thoracic Society. 2006.
  31. Baron RM. Critical Care Medicine. Winshall JS, Lederman RJ, editors. Tarascon Internal Medicine and Critical Care Pocketbook. 2006.
  32. Wang Y, Baron RM, Zhu G, Joo M, Christman JW, Silverman ES, Perrella MA, Riese RJ, Cernadas M. PU.1 regulates cathepsin S expression in professional APCs. J Immunol. 2006 Jan 1; 176(1):275-83.
    View in: PubMed
  33. Baron R, Macias A, Cheng G, Grant M, Rigby A, von Andrian UH, Perrella MA. Interference with AT-Rich DNA Binding Attenuates NOS2 Induction and Improves Outcomes from Murine Endotoxemic Shock [abstract]. 2006 ASCI/AAP Joint Meeting Poster Abstracts. 2006.
  34. Baron RM. Pulmonary Medicine. Winshall JS, Lederman RJ, editors. Tarascon Internal Medicine and Critical Care Pocketbook. 2006.
  35. Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA. Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels. Cell Mol Biol. 2005; 51(5):513-520.
  36. Fredenburgh LE, Ejima K, Baron RM, Chung SW, Layne MD, Perrella MA . Enhanced COX-2 Expression in HO-1 Null Mice Contributes to Endotoxemic Lung Injury [abstract] . Proceedings of the American Thoracic Society. 2005; 2:A152.
  37. Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA. Absence of Heme Oxygenase-1 Expression in the Lung Parenchyma Exacerbates Endotoxin-Induced Acute Lung Injury [abstract]. Heme Oxygenase-1 International Conference Proceedings. 2005.
  38. Baron RM, Macias AA, Fredenburgh LE, Okabe RO, Layne MD, Perrella MA. Reduction of Nitric Oxide Synthase-2 Expression by Minor Groove Binding Agents Improves Survival from Endotoxemia [abstract] . Proceedings of the American Thoracic Society. 2005; 2:A930.
  39. Baron BW, Anastasi J, Montag A, Huo D, Baron RM, Karrison T, Thirman MJ, Subudhi SK, Chin RK, Felsher DW, Fu YX, McKeithan TW, Baron JM. The human BCL6 transgene promotes the development of lymphomas in the mouse. Proc Natl Acad Sci U S A. 2004 Sep 28; 101(39):14198-203.
    View in: PubMed
  40. Baron RM, Carvajal IM, Liu X, Okabe RO, Fredenburgh LE, Macias AA, Chen YH, Ejima K, Layne MD, Perrella MA. Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia. J Immunol. 2004 Sep 15; 173(6):4147-53.
    View in: PubMed
  41. Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Cullivan ML, Haley KJ, Sonna LA, De Sanctis GT, Ingenito EP, Perrella MA. Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice. FASEB J. 2004 Aug; 18(11):1276-8.
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  42. Fredenburgh LE, Ejima K, Liu X, Baron RM, Perrella MA. Attenuation of Hypotension in COX-2 Null Mice Contributes to Improved Outcome in Endotoxemia [abstract] . Am J Resp Crit Care Med. 2004; 30:A636.
  43. Baron RM. Pulmonary Medicine. Winshall JS, Lederman RJ, editors. Tarascon Internal Medicine and Critical Care Pocketbook. 2004; 130-140.
  44. Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Haley KJ, Sonna LA, De Sanctis GT, Ingenito EP, Perrella MA . Nitric Oxide Synthase-2 Mediates Acute Lung Injury in Mice through Decreased Surfactant Protein-B Expression [abstract] . Am J Resp Crit Care Med. 2004; 30:A264.
  45. Baron RM. Critical Care Medicine. Winshall JS, Lederman RJ, editors. Tarascon Internal Medicine and Critical Care Pocketbook. 2004; 44-55.
  46. Chen YH, Layne MD, Chung SW, Ejima K, Baron RM, Yet SF, Perrella MA. Elk-3 is a transcriptional repressor of nitric-oxide synthase 2. J Biol Chem. 2003 Oct 10; 278(41):39572-7.
    View in: PubMed
  47. Ejima K, Layne MD, Carvajal IM, Kritek PA, Baron RM, Chen YH, Vom Saal J, Levy BD, Yet SF, Perrella MA. Cyclooxygenase-2-deficient mice are resistant to endotoxin-induced inflammation and death. FASEB J. 2003 Jul; 17(10):1325-7.
    View in: PubMed
  48. Baron R.M., Carvajal I.M., Ejima K., Chen Y.H., Ith B., Layne M.D., Yet S.F., Perrella M.A. Distamycin A Inhibits Binding of High Mobility Group-I/Y Protein to the Nitric Oxide Synthase 2 Promoter and Improves Mouse Survival from Endotoxemia [abstract] . Am J Resp Crit Care Med. 2003; 28:A728.
  49. Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Haley KJ, Sonna LA, De Sanctis GT, Ingenito EP, Perrella MA . NOS2 downregulates expression of SP-B and enhances endotoxin-induced lung injury in mice [abstract]. Circulation. 2003.
  50. Baron RM, Fanta CH. Hemoptysis. Branch WT, editor. Office Practice of Medicine. 2003; 285-292.
  51. Chen Y-H, Layne MD, Ejima K, Baron RM, Yet S-F, Perrella MA. Elk3 Is a Transcriptional Repressor of Nitric Oxide Synthase 2 in Macrophages [abstract] . Am J Resp Crit Care Med. 2003; 28:A50.
  52. Silverman ES, Baron RM, Palmer LJ, Le L, Hallock A, Subramaniam V, Riese RJ, McKenna MD, Gu X, Libermann TA, Tugores A, Haley KJ, Shore S, Drazen JM, Weiss ST. Constitutive and cytokine-induced expression of the ETS transcription factor ESE-3 in the lung. Am J Respir Cell Mol Biol. 2002 Dec; 27(6):697-704.
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  53. Baron RM, Palmer LJ, Tantisira K, Gabriel S, Sonna LA, Le L, Hallock A, Libermann TA, Drazen JM, Weiss ST, Silverman ES. DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma. Am J Respir Crit Care Med. 2002 Oct 1; 166(7):927-32.
    View in: PubMed
  54. Storm van's Gravesande K, Layne MD, Ye Q, Le L, Baron RM, Perrella MA, Santambrogio L, Silverman ES, Riese RJ. IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression. J Immunol. 2002 May 1; 168(9):4488-94.
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  55. Silverman ES, Le L, Baron RM, Hallock A, Hjoberg J, Shikanai T, Storm van's Gravesande K, Auron PE, Lu W. Cloning and functional analysis of the mouse 5-lipoxygenase promoter. Am J Respir Cell Mol Biol. 2002 Apr; 26(4):475-83.
    View in: PubMed
  56. Baron RM. Book Review: Preoperative Assessment. Ed: Cashman JN [review]. J Intensive Care Med. 2002; 17:96.
  57. Baron RM, Palmer LJ, Haley KH, Sonna L, Freedman M, Gabriel S, Drazen JM, Weiss ST, Silverman ES. An Association Study Of DNA Sequence Variants In The Epithelium-Specific ETS Transcription Factors ESE-2 And ESE-3 With Asthma [abstract] . Am J Resp Crit Care Med. 2002; 26.
  58. Carvajal IM, Baron RM, Perrella MA. High-mobility group-I/Y proteins: Potential role in the pathophysiology of critical illnesses. Crit Care Med. 2002 Jan; 30(1 Supp):S36-S42.
    View in: PubMed
  59. Baron RM, Carvajal IM, Pellacani A, Chen Y-H, Ejima K, Ith B, Layne MD, Yet S-F, Perrella MA. High Mobility Group-I/Y Protein Binds To The Interferon Regulatory Region Of Murine Nitric Oxide Synthase 2 Promoter [abstract] . Am J Resp Crit Care Med. 2002; 26.
  60. Ejima K, Layne MD, Kritek PA, Carvajal IM, Baron RM, Ith B, Yet S-F, Perrella MA. Lung Response To Endotoxemia In The Absence Of Cyclooxygeanse-2 [abstract] . Am J Resp Crit Care Med. 2002.
  61. Carvajal IM, Baron RM, Perrella MA. High-mobility group-I/Y proteins: potential role in the pathophysiology of critical illnesses. Crit Care Med. 2002 Jan; 30(1 Suppl):S36-42.
    View in: PubMed
  62. Baron RM, Schwartzstein RM. Diseases of the Chest Wall [review]. UpToDate. 2001.
  63. Baron R, Silverman ES, Grasemann H, Collins T, Drazen JM. DNA sequence variants of platelet-derived growth factor A-chain gene. Clin Exp All. 2001; 31:1501-1508.
  64. Silverman ES, Liggett SB, Gelfand EW, Rosenwasser LJ, Baron RM, Bolk S, Weiss ST, Drazen JM. The pharmacogenetics of asthma: A candidate gene approach [review]. Pharmacogenetics. 2001; 1:27-37.
  65. Baron RM, Goldhaber SZ. Deep venous thrombosis: early discharge strategies and outpatient management. J Thromb Thrombolysis. 1999 Apr; 7(2):113-22.
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  66. Miyahara E, Pokorny J, Smith VC, Baron R, Baron E. Color vision in two observers with highly biased LWS/MWS cone ratios. Vision Res. 1998 Feb; 38(4):601-12.
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  67. Baron RM, Goldhaber SZ. Deep Venous Thrombosis: Early Discharge Strategies and Outpatient Management. J Thromb Thrombolysis. 1997; 4(3/4):365-374.
    View in: PubMed
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