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Deborah Burstein, PH.D.

TitleAssociate Professor of Radiology and Health Sciences and Technology
InstitutionBeth Israel Deaconess Medical Center
DepartmentRadiology
AddressBeth Israel Deaconess Med Ctr
Him-148
4 Blackfan Cir
Boston MA 02115
Phone617/667-3349
Fax617/667-7021
Other Positions
TitleMember of the Faculty of the Harvard-MIT Division of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology


 Mentoring 
 completed student projects
Use of MRI to Visualize Cartilage Damage
Summer, 06/01/99 - 07/30/99
Delayed Gadolinium Enhanced MRI of Autologous Chondrocyte Implants In Vivo
Summer, 06/01/00 - 07/31/00

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Guermazi A, Roemer FW, Burstein D, Hayashi D. Why radiography should no longer be considered a surrogate outcome measure for longitudinal assessment of cartilage in knee osteoarthritis. Arthritis Res Ther. 2011; 13(6):247.
    View in: PubMed
  2. Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman IE, Arany Z, Parikh SM. PGC-1a promotes recovery after acute kidney injury during systemic inflammation in mice. J Clin Invest. 2011 Oct; 121(10):4003-14.
    View in: PubMed
  3. Cohen SB, Proudman S, Kivitz AJ, Burch FX, Donohue JP, Burstein D, Sun YN, Banfield C, Vincent MS, Ni L, Zack DJ. A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee. Arthritis Res Ther. 2011; 13(4):R125.
    View in: PubMed
  4. Crema MD, Roemer FW, Marra MD, Burstein D, Gold GE, Eckstein F, Baum T, Mosher TJ, Carrino JA, Guermazi A. Articular cartilage in the knee: current MR imaging techniques and applications in clinical practice and research. Radiographics. 2011 Jan-Feb; 31(1):37-61.
    View in: PubMed
  5. Li W, Scheidegger R, Wu Y, Edelman RR, Farley M, Krishnan N, Burstein D, Prasad PV. Delayed contrast-enhanced MRI of cartilage: comparison of nonionic and ionic contrast agents. Magn Reson Med. 2010 Nov; 64(5):1267-73.
    View in: PubMed
  6. Hunter DJ, Losina E, Guermazi A, Burstein D, Lassere MN, Kraus V. A pathway and approach to biomarker validation and qualification for osteoarthritis clinical trials. Curr Drug Targets. 2010 May; 11(5):536-45.
    View in: PubMed
  7. Burstein D, Gray M, Mosher T, Dardzinski B. Measures of molecular composition and structure in osteoarthritis. Radiol Clin North Am. 2009 Jul; 47(4):675-86.
    View in: PubMed
  8. Jessel RH, Zurakowski D, Zilkens C, Burstein D, Gray ML, Kim YJ. Radiographic and patient factors associated with pre-radiographic osteoarthritis in hip dysplasia. J Bone Joint Surg Am. 2009 May; 91(5):1120-9.
    View in: PubMed
  9. Dugar A, Farley ML, Wang AL, Goldring MB, Goldring SR, Swaim BH, Bierbaum BE, Burstein D, Gray ML. The effect of paraformaldehyde fixation on the delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) measurement. J Orthop Res. 2009 Apr; 27(4):536-9.
    View in: PubMed
  10. Burstein D, Hunter DJ. "Why aren't we there yet?" Re-examining standard paradigms in imaging of OA: summary of the 2nd annual workshop on imaging based measures of osteoarthritis. Osteoarthritis Cartilage. 2009 May; 17(5):571-8.
    View in: PubMed
  11. Burstein D. Tracking longitudinal changes in knee degeneration and repair. J Bone Joint Surg Am. 2009 Feb; 91 Suppl 1:51-3.
    View in: PubMed
  12. Guermazi A, Eckstein F, Hellio Le Graverand-Gastineau MP, Conaghan PG, Burstein D, Keen H, Roemer FW. Osteoarthritis: current role of imaging. Med Clin North Am. 2009 Jan; 93(1):101-26, xi.
    View in: PubMed
  13. Mamisch TC, Dudda M, Hughes T, Burstein D, Kim YJ. Comparison of delayed gadolinium enhanced MRI of cartilage (dGEMRIC) using inversion recovery and fast T1 mapping sequences. Magn Reson Med. 2008 Oct; 60(4):768-73.
    View in: PubMed
  14. Guermazi A, Burstein D, Conaghan P, Eckstein F, Hellio Le Graverand-Gastineau MP, Keen H, Roemer FW. Imaging in osteoarthritis. Rheum Dis Clin North Am. 2008 Aug; 34(3):645-87.
    View in: PubMed
  15. Gray ML, Burstein D, Kim YJ, Maroudas A. 2007 Elizabeth Winston Lanier Award Winner. Magnetic resonance imaging of cartilage glycosaminoglycan: basic principles, imaging technique, and clinical applications. J Orthop Res. 2008 Mar; 26(3):281-91.
    View in: PubMed
  16. Williams A, Shetty SK, Burstein D, Day CS, McKenzie C. Delayed gadolinium enhanced MRI of cartilage (dGEMRIC) of the first carpometacarpal (1CMC) joint: a feasibility study. Osteoarthritis Cartilage. 2008 Apr; 16(4):530-2.
    View in: PubMed
  17. Williams A, Mikulis B, Krishnan N, Gray M, McKenzie C, Burstein D. Suitability of T(1Gd) as the dGEMRIC index at 1.5T and 3.0T. Magn Reson Med. 2007 Oct; 58(4):830-4.
    View in: PubMed
  18. Baldassarri M, Goodwin JS, Farley ML, Bierbaum BE, Goldring SR, Goldring MB, Burstein D, Gray ML. Relationship between cartilage stiffness and dGEMRIC index: correlation and prediction. J Orthop Res. 2007 Jul; 25(7):904-12.
    View in: PubMed
  19. Krishnan N, Shetty SK, Williams A, Mikulis B, McKenzie C, Burstein D. Delayed gadolinium-enhanced magnetic resonance imaging of the meniscus: an index of meniscal tissue degeneration? Arthritis Rheum. 2007 May; 56(5):1507-11.
    View in: PubMed
  20. Tiderius CJ, Jessel R, Kim YJ, Burstein D. Hip dGEMRIC in asymptomatic volunteers and patients with early osteoarthritis: the influence of timing after contrast injection. Magn Reson Med. 2007 Apr; 57(4):803-5.
    View in: PubMed
  21. Deng X, Farley M, Nieminen MT, Gray M, Burstein D. Diffusion tensor imaging of native and degenerated human articular cartilage. Magn Reson Imaging. 2007 Feb; 25(2):168-71.
    View in: PubMed
  22. Eckstein F, Burstein D, Link TM. Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis. NMR Biomed. 2006 Nov; 19(7):822-54.
    View in: PubMed
  23. McKenzie CA, Williams A, Prasad PV, Burstein D. Three-dimensional delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 1.5T and 3.0T. J Magn Reson Imaging. 2006 Oct; 24(4):928-33.
    View in: PubMed
  24. Burstein D. MRI for development of disease-modifying osteoarthritis drugs. NMR Biomed. 2006 Oct; 19(6):669-80.
    View in: PubMed
  25. Tiderius C, Hori M, Williams A, Sharma L, Prasad PV, Finnell M, McKenzie C, Burstein D. dGEMRIC as a function of BMI. Osteoarthritis Cartilage. 2006 Nov; 14(11):1091-7.
    View in: PubMed
  26. Gold GE, Burstein D, Dardzinski B, Lang P, Boada F, Mosher T. MRI of articular cartilage in OA: novel pulse sequences and compositional/functional markers. Osteoarthritis Cartilage. 2006; 14 Suppl A:A76-86.
    View in: PubMed
  27. Kimelman T, Vu A, Storey P, McKenzie C, Burstein D, Prasad P. Three-dimensional T1 mapping for dGEMRIC at 3.0 T using the Look Locker method. Invest Radiol. 2006 Feb; 41(2):198-203.
    View in: PubMed
  28. Williams A, Sharma L, McKenzie CA, Prasad PV, Burstein D. Delayed gadolinium-enhanced magnetic resonance imaging of cartilage in knee osteoarthritis: findings at different radiographic stages of disease and relationship to malalignment. Arthritis Rheum. 2005 Nov; 52(11):3528-35.
    View in: PubMed
  29. Samosky JT, Burstein D, Eric Grimson W, Howe R, Martin S, Gray ML. Spatially-localized correlation of dGEMRIC-measured GAG distribution and mechanical stiffness in the human tibial plateau. J Orthop Res. 2005 Jan; 23(1):93-101.
    View in: PubMed
  30. Gray ML, Burstein D. Molecular (and functional) imaging of articular cartilage. J Musculoskelet Neuronal Interact. 2004 Dec; 4(4):365-8.
    View in: PubMed
  31. Burstein D, Williams A, McKenzie C, Woertler K, Rummeny EJ. Potential for misinterpretation of combined T1- and T2-weighted contrast-enhanced MR imaging of cartilage. Radiology. 2004 Nov; 233(2):619-20; author reply 621-2.
    View in: PubMed
  32. Himes N, Min JY, Lee R, Brown C, Shea J, Huang X, Xiao YF, Morgan JP, Burstein D, Oettgen P. In vivo MRI of embryonic stem cells in a mouse model of myocardial infarction. Magn Reson Med. 2004 Nov; 52(5):1214-9.
    View in: PubMed
  33. Nieminen MT, Menezes NM, Williams A, Burstein D. T2 of articular cartilage in the presence of Gd-DTPA2-. Magn Reson Med. 2004 Jun; 51(6):1147-52.
    View in: PubMed
  34. Sun Y, Schmidt NO, Schmidt K, Doshi S, Rubin JB, Mulkern RV, Carroll R, Ziu M, Erkmen K, Poussaint TY, Black P, Albert M, Burstein D, Kieran MW. Perfusion MRI of U87 brain tumors in a mouse model. Magn Reson Med. 2004 May; 51(5):893-9.
    View in: PubMed
  35. Menezes NM, Gray ML, Hartke JR, Burstein D. T2 and T1rho MRI in articular cartilage systems. Magn Reson Med. 2004 Mar; 51(3):503-9.
    View in: PubMed
  36. Weis S, Shintani S, Weber A, Kirchmair R, Wood M, Cravens A, McSharry H, Iwakura A, Yoon YS, Himes N, Burstein D, Doukas J, Soll R, Losordo D, Cheresh D. Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction. J Clin Invest. 2004 Mar; 113(6):885-94.
    View in: PubMed
  37. Williams A, Gillis A, McKenzie C, Po B, Sharma L, Micheli L, McKeon B, Burstein D. Glycosaminoglycan distribution in cartilage as determined by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): potential clinical applications. AJR Am J Roentgenol. 2004 Jan; 182(1):167-72.
    View in: PubMed
  38. Kim YJ, Jaramillo D, Millis MB, Gray ML, Burstein D. Assessment of early osteoarthritis in hip dysplasia with delayed gadolinium-enhanced magnetic resonance imaging of cartilage. J Bone Joint Surg Am. 2003 Oct; 85-A(10):1987-92.
    View in: PubMed
  39. Nelson AL, Algon SA, Munasinghe J, Graves O, Goumnerova L, Burstein D, Pomeroy SL, Kim JY. Magnetic resonance imaging of patched heterozygous and xenografted mouse brain tumors. J Neurooncol. 2003 May; 62(3):259-67.
    View in: PubMed
  40. Williams A, Oppenheimer RA, Gray ML, Burstein D. Differential recovery of glycosaminoglycan after IL-1-induced degradation of bovine articular cartilage depends on degree of degradation. Arthritis Res Ther. 2003; 5(2):R97-105.
    View in: PubMed
  41. Burstein D, Gray M. New MRI techniques for imaging cartilage. J Bone Joint Surg Am. 2003; 85-A Suppl 2:70-7.
    View in: PubMed
  42. Burstein D, Gray ML. . Potential of molecular imaging of cartilage. Sports Med Arthtoscopy Review. 2003; 11:182-191.
  43. Bashir A, Nieminen M, Williams A, Burstein D. T1 of Cartilage with Gd-DTPA 2- and GdHPD03A: Implications for dGEMRIC Imaging. Magn Reson Med. 2003.
  44. Henkelman RM, Stanisz GJ, Menezes N, Burstein D. Can MTR be used to assess cartilage in the presence of Gd-DTPA2-? Magn Reson Med. 2002 Dec; 48(6):1081-4.
    View in: PubMed
  45. Gillis A, Gray M, Burstein D. Relaxivity and diffusion of gadolinium agents in cartilage. Magn Reson Med. 2002 Dec; 48(6):1068-71.
    View in: PubMed
  46. Gillis A, Bashir A, McKeon B, Scheller A, Gray ML, Burstein D. Magnetic resonance imaging of relative glycosaminoglycan distribution in patients with autologous chondrocyte transplants. Invest Radiol. 2001 Dec; 36(12):743-8.
    View in: PubMed
  47. Gray ML, Burstein D, Xia Y. Biochemical (and functional) imaging of articular cartilage. Semin Musculoskelet Radiol. 2001 Dec; 5(4):329-43.
    View in: PubMed
  48. Recht M, Bobic V, Burstein D, Disler D, Gold G, Gray M, Kramer J, Lang P, McCauley T, Winalski C. Magnetic resonance imaging of articular cartilage. Clin Orthop Relat Res. 2001 Oct; (391 Suppl):S379-96.
    View in: PubMed
  49. Burstein D, Velyvis J, Scott KT, Stock KW, Kim YJ, Jaramillo D, Boutin RD, Gray ML. Protocol issues for delayed Gd(DTPA)(2-)-enhanced MRI (dGEMRIC) for clinical evaluation of articular cartilage. Magn Reson Med. 2001 Jan; 45(1):36-41.
    View in: PubMed
  50. Burstein D, Bashir A, Gray ML. MRI techniques in early stages of cartilage disease. Invest Radiol. 2000 Oct; 35(10):622-38.
    View in: PubMed
  51. Rosen GD, Burstein D, Galaburda AM. Changes in efferent and afferent connectivity in rats with induced cerebrocortical microgyria. J Comp Neurol. 2000 Mar 20; 418(4):423-40.
    View in: PubMed
  52. Allen RG, Burstein D, Gray ML. Monitoring glycosaminoglycan replenishment in cartilage explants with gadolinium-enhanced magnetic resonance imaging. J Orthop Res. 1999 May; 17(3):430-6.
    View in: PubMed
  53. Bashir A, Gray ML, Hartke J, Burstein D. Nondestructive imaging of human cartilage glycosaminoglycan concentration by MRI. Magn Reson Med. 1999 May; 41(5):857-65.
    View in: PubMed
  54. Fung SH, Burstein D, Born RT. In vivo microelectrode track reconstruction using magnetic resonance imaging. J Neurosci Methods. 1998 Apr 30; 80(2):215-24.
    View in: PubMed
  55. Rosen GD, Burstein D. MRI visualization of focal induced neocortical malformations of the rat. Neuroreport. 1997 Dec 22; 8(18):3883-7.
    View in: PubMed
  56. Bashir A, Gray ML, Boutin RD, Burstein D. Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. Radiology. 1997 Nov; 205(2):551-8.
    View in: PubMed
  57. Chao H, Burstein D. Multibolus stimulated echo imaging of coronary artery flow. J Magn Reson Imaging. 1997 May-Jun; 7(3):603-5.
    View in: PubMed
  58. Donahue KM, Weisskoff RM, Burstein D. Water diffusion and exchange as they influence contrast enhancement. J Magn Reson Imaging. 1997 Jan-Feb; 7(1):102-10.
    View in: PubMed
  59. Bashir A, Gray ML, Burstein D. Gd-DTPA2- as a measure of cartilage degradation. Magn Reson Med. 1996 Nov; 36(5):665-73.
    View in: PubMed
  60. Burstein D. Stimulated echoes: description, applications, and practical hints. Concepts Magn Reson. 1996; 8:269-278.
  61. Gray ML, Burstein D, Lesperance LM, Gehrke L. Magnetization transfer in cartilage and its constituent macromolecules. Magn Reson Med. 1995 Sep; 34(3):319-25.
    View in: PubMed
  62. Donahue KM, Burstein D, Manning WJ, Gray ML. Studies of Gd-DTPA relaxivity and proton exchange rates in tissue. Magn Reson Med. 1994 Jul; 32(1):66-76.
    View in: PubMed
  63. Prasad PV, Burstein D, Edelman RR. MRI evaluation of myocardial perfusion without a contrast agent using magnetization transfer. Magn Reson Med. 1993 Aug; 30(2):267-70.
    View in: PubMed
  64. Burstein D, Gray ML, Hartman AL, Gipe R, Foy BD. Diffusion of small solutes in cartilage as measured by nuclear magnetic resonance (NMR) spectroscopy and imaging. J Orthop Res. 1993 Jul; 11(4):465-78.
    View in: PubMed
  65. Foy BD, Burstein D. Characteristics of extracellular sodium relaxation in perfused hearts with pathologic interventions. Magn Reson Med. 1992 Oct; 27(2):270-83.
    View in: PubMed
  66. Lesperance LM, Gray ML, Burstein D. Determination of fixed charge density in cartilage using nuclear magnetic resonance. J Orthop Res. 1992 Jan; 10(1):1-13.
    View in: PubMed
  67. Edelman RR, Manning WJ, Burstein D, Paulin S. Coronary arteries: breath-hold MR angiography. Radiology. 1991 Dec; 181(3):641-3.
    View in: PubMed
  68. Burstein D, Taratuta E, Manning WJ. Factors in myocardial "perfusion" imaging with ultrafast MRI and Gd-DTPA administration. Magn Reson Med. 1991 Aug; 20(2):299-305.
    View in: PubMed
  69. Burstein D. MR imaging of coronary artery flow in isolated and in vivo hearts. J Magn Reson Imaging. 1991 May-Jun; 1(3):337-46.
    View in: PubMed
  70. Powell D, Burstein D, Fossel ET. Nuclear magnetic resonance studies of sodium/calcium exchange in frog perfused, beating hearts. Eur J Biochem. 1990 Nov 13; 193(3):887-9.
    View in: PubMed
  71. Foy BD, Burstein D. Interstitial sodium nuclear magnetic resonance relaxation times in perfused hearts. Biophys J. 1990 Jul; 58(1):127-34.
    View in: PubMed
  72. Boruchoff SE, Woda BA, Pihan GA, Durbin WA, Burstein D, Blacklow NR. Parvovirus B19-associated hemophagocytic syndrome. Arch Intern Med. 1990 Apr; 150(4):897-9.
    View in: PubMed
  73. Manning WJ, Wei JY, Fossel ET, Burstein D. Measurement of left ventricular mass in rats using electrocardiogram-gated magnetic resonance imaging. Am J Physiol. 1990 Apr; 258(4 Pt 2):H1181-6.
    View in: PubMed
  74. Atkinson DJ, Burstein D, Edelman RR. First-pass cardiac perfusion: evaluation with ultrafast MR imaging. Radiology. 1990 Mar; 174(3 Pt 1):757-62.
    View in: PubMed
  75. Burstein D, Litt HI, Fossel ET. NMR characteristics of "visible" intracellular myocardial potassium in perfused rat hearts. Magn Reson Med. 1989 Jan; 9(1):66-78.
    View in: PubMed
  76. Burstein D, Mattingly M. . Magnetic Resonance imaging of intracellular sodium. J Magn Reson. 1989; 83:197-204.
  77. Burstein D. On the in vivo detection of intracellular water and sodium by nuclear magnetic resonance with shift reagents. Biophys J. 1988 Jul; 54(1):191-2.
    View in: PubMed
  78. Burstein D, Fossel ET. Nuclear magnetic resonance studies of intracellular ions in perfused frog heart. Am J Physiol. 1987 Jun; 252(6 Pt 2):H1138-46.
    View in: PubMed
  79. Burstein D, Fossel ET. Intracellular sodium and lithium NMR relaxation times in the perfused frog heart. Magn Reson Med. 1987 Mar; 4(3):261-73.
    View in: PubMed
  80. Burstein D, Fossel ET. . Effects of temperature, buffer osmolarity, and shift reagent concentration on the introcellular sodium and potassium relaxation times of red blood cells. J Magn Reson. 1987; 73:150-158.
  81. Burstein D, Cohen D. . Comparison of magnetic field and electric potential produced by frog heart muscle. J Appl Phys. 1985; 57:2640-2646.
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