 Harald Paganetti, Ph.D.
| Title | Professor of Radiation Oncology |
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| Institution | Massachusetts General Hospital |
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| Department | Radiation Oncology |
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| Address | Massachusetts General Hospital
Radiation Oncology
55 Fruit St
Boston MA 02114
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| Phone | 617/726-5847 |
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| Fax | 617/726-2098 |
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 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Paganetti H, van Luijk P. Biological considerations when comparing proton therapy with photon therapy. Semin Radiat Oncol. 2013 Apr; 23(2):77-87.
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Carabe A, España S, Grassberger C, Paganetti H. Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver. Phys Med Biol. 2013 Apr 7; 58(7):2103-17.
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Besemer A, Paganetti H, Bednarz B. The clinical impact of uncertainties in the mean excitation energy of human tissues during proton therapy. Phys Med Biol. 2013 Feb 21; 58(4):887-902.
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Paganetti H, Fontenot J. Proton therapy physics. Med Phys. 2013 Jan; 40(1):017301.
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Jia X, Schümann J, Paganetti H, Jiang SB. GPU-based fast Monte Carlo dose calculation for proton therapy. Phys Med Biol. 2012 Dec 7; 57(23):7783-97.
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Perl J, Shin J, Schumann J, Faddegon B, Paganetti H. TOPAS: an innovative proton Monte Carlo platform for research and clinical applications. Med Phys. 2012 Nov; 39(11):6818-37.
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Paganetti H. Assessment of the risk for developing a second malignancy from scattered and secondary radiation in radiation therapy. Health Phys. 2012 Nov; 103(5):652-61.
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Butterworth KT, McGarry CK, Clasie B, Carabe-Fernandez A, Schuemann J, Depauw N, Tang S, McMahon SJ, Schettino G, O'Sullivan JM, Lu HM, Kooy H, Paganetti H, Hounsell AR, Held KD, Prise KM. Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries. Phys Med Biol. 2012 Oct 21; 57(20):6671-80.
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Titt U, Bednarz B, Paganetti H. Comparison of MCNPX and Geant4 proton energy deposition predictions for clinical use. Phys Med Biol. 2012 Oct 21; 57(20):6381-93.
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Paganetti H, Athar BS, Moteabbed M, A Adams J, Schneider U, Yock TI. Assessment of radiation-induced second cancer risks in proton therapy and IMRT for organs inside the primary radiation field. Phys Med Biol. 2012 Oct 7; 57(19):6047-61.
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Schümann J, Paganetti H, Shin J, Faddegon B, Perl J. Efficient voxel navigation for proton therapy dose calculation in TOPAS and Geant4. Phys Med Biol. 2012 Jun 7; 57(11):3281-93.
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Paganetti H. Range uncertainties in proton therapy and the role of Monte Carlo simulations. Phys Med Biol. 2012 Jun 7; 57(11):R99-117.
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Shin J, Perl J, Schümann J, Paganetti H, Faddegon BA. A modular method to handle multiple time-dependent quantities in Monte Carlo simulations. Phys Med Biol. 2012 Jun 7; 57(11):3295-308.
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Dowdell SJ, Clasie B, Depauw N, Metcalfe P, Rosenfeld AB, Kooy HM, Flanz JB, Paganetti H. Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy. Phys Med Biol. 2012 May 21; 57(10):2829-42.
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Efstathiou JA, Paly JJ, Lu HM, Athar BS, Moteabbed M, Niemierko A, Adams JA, Bekelman JE, Shipley WU, Zietman AL, Paganetti H. Adjuvant radiation therapy for early stage seminoma: proton versus photon planning comparison and modeling of second cancer risk. Radiother Oncol. 2012 Apr; 103(1):12-7.
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Carabe A, Moteabbed M, Depauw N, Schuemann J, Paganetti H. Range uncertainty in proton therapy due to variable biological effectiveness. Phys Med Biol. 2012 Mar 7; 57(5):1159-72.
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Moteabbed M, Geyer A, Drenkhahn R, Bolch WE, Paganetti H. Comparison of whole-body phantom designs to estimate organ equivalent neutron doses for secondary cancer risk assessment in proton therapy. Phys Med Biol. 2012 Jan 21; 57(2):499-515.
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Remmele S, Hesser J, Paganetti H, Bortfeld T. A deconvolution approach for PET-based dose reconstruction in proton radiotherapy. Phys Med Biol. 2011 Dec 7; 56(23):7601-19.
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Grassberger C, Paganetti H. Elevated LET components in clinical proton beams. Phys Med Biol. 2011 Oct 21; 56(20):6677-91.
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Attanasi F, Knopf A, Parodi K, Paganetti H, Bortfeld T, Rosso V, Del Guerra A. Extension and validation of an analytical model for in vivo PET verification of proton therapy--a phantom and clinical study. Phys Med Biol. 2011 Aug 21; 56(16):5079-98.
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Rinaldi I, Ferrari A, Mairani A, Paganetti H, Parodi K, Sala P. An integral test of FLUKA nuclear models with 160 MeV proton beams in multi-layer Faraday cups. Phys Med Biol. 2011 Jul 7; 56(13):4001-11.
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Zhu X, España S, Daartz J, Liebsch N, Ouyang J, Paganetti H, Bortfeld TR, El Fakhri G. Monitoring proton radiation therapy with in-room PET imaging. Phys Med Biol. 2011 Jul 7; 56(13):4041-57.
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España S, Paganetti H. Uncertainties in planned dose due to the limited voxel size of the planning CT when treating lung tumors with proton therapy. Phys Med Biol. 2011 Jul 7; 56(13):3843-56.
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Bednarz B, Lu HM, Engelsman M, Paganetti H. Uncertainties and correction methods when modeling passive scattering proton therapy treatment heads with Monte Carlo. Phys Med Biol. 2011 May 7; 56(9):2837-54.
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España S, Zhu X, Daartz J, El Fakhri G, Bortfeld T, Paganetti H. The reliability of proton-nuclear interaction cross-section data to predict proton-induced PET images in proton therapy. Phys Med Biol. 2011 May 7; 56(9):2687-98.
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Moteabbed M, España S, Paganetti H. Monte Carlo patient study on the comparison of prompt gamma and PET imaging for range verification in proton therapy. Phys Med Biol. 2011 Feb 21; 56(4):1063-82.
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Carabe-Fernandez A, Dale RG, Paganetti H. Repair kinetic considerations in particle beam radiotherapy. Br J Radiol. 2011 Jun; 84(1002):546-55.
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Grassberger C, Trofimov A, Lomax A, Paganetti H. Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning. Int J Radiat Oncol Biol Phys. 2011 Aug 1; 80(5):1559-66.
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Athar BS, Paganetti H. Comparison of second cancer risk due to out-of-field doses from 6-MV IMRT and proton therapy based on 6 pediatric patient treatment plans. Radiother Oncol. 2011 Jan; 98(1):87-92.
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España S, Paganetti H. The impact of uncertainties in the CT conversion algorithm when predicting proton beam ranges in patients from dose and PET-activity distributions. Phys Med Biol. 2010 Dec 21; 55(24):7557-71.
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Bednarz B, Daartz J, Paganetti H. Dosimetric accuracy of planning and delivering small proton therapy fields. Phys Med Biol. 2010 Dec 21; 55(24):7425-38.
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Carabe-Fernandez A, Dale RG, Hopewell JW, Jones B, Paganetti H. Fractionation effects in particle radiotherapy: implications for hypo-fractionation regimes. Phys Med Biol. 2010 Oct 7; 55(19):5685-700.
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Sarfehnia A, Clasie B, Chung E, Lu HM, Flanz J, Cascio E, Engelsman M, Paganetti H, Seuntjens J. Direct absorbed dose to water determination based on water calorimetry in scanning proton beam delivery. Med Phys. 2010 Jul; 37(7):3541-50.
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Knopf AC, Parodi K, Paganetti H, Bortfeld T, Daartz J, Engelsman M, Liebsch N, Shih H. Accuracy of proton beam range verification using post-treatment positron emission tomography/computed tomography as function of treatment site. Int J Radiat Oncol Biol Phys. 2011 Jan 1; 79(1):297-304.
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Gensheimer MF, Yock TI, Liebsch NJ, Sharp GC, Paganetti H, Madan N, Grant PE, Bortfeld T. In vivo proton beam range verification using spine MRI changes. Int J Radiat Oncol Biol Phys. 2010 Sep 1; 78(1):268-75.
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Athar BS, Bednarz B, Seco J, Hancox C, Paganetti H. Comparison of out-of-field photon doses in 6 MV IMRT and neutron doses in proton therapy for adult and pediatric patients. Phys Med Biol. 2010 May 21; 55(10):2879-91.
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Paganetti H, Kooy H. Proton radiation in the management of localized cancer. Expert Rev Med Devices. 2010 Mar; 7(2):275-85.
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Suit H, DeLaney T, Goldberg S, Paganetti H, Clasie B, Gerweck L, Niemierko A, Hall E, Flanz J, Hallman J, Trofimov A. Proton vs carbon ion beams in the definitive radiation treatment of cancer patients. Radiother Oncol. 2010 Apr; 95(1):3-22.
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Xu XG, Paganetti H. Better radiation weighting factors for neutrons generated from proton treatment are needed. Radiat Prot Dosimetry. 2010 Mar; 138(4):291-4.
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McGurk R, Seco J, Riboldi M, Wolfgang J, Segars P, Paganetti H. Extension of the NCAT phantom for the investigation of intra-fraction respiratory motion in IMRT using 4D Monte Carlo. Phys Med Biol. 2010 Mar 7; 55(5):1475-90.
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Clasie B, Wroe A, Kooy H, Depauw N, Flanz J, Paganetti H, Rosenfeld A. Assessment of out-of-field absorbed dose and equivalent dose in proton fields. Med Phys. 2010 Jan; 37(1):311-21.
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Paganetti H, Athar BS, Bednarz B. Dose-rate effects when estimating risks for second malignancies: in regard to Fontenot et al (Int J Radiat Oncol Biol Phys 2009;74:616-622). Int J Radiat Oncol Biol Phys. 2009 Dec 1; 75(5):1624; author reply 1624-5.
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Henkner K, Sobolevsky N, Jäkel O, Paganetti H. Test of the nuclear interaction model in SHIELD-HIT and comparison to energy distributions from GEANT4. Phys Med Biol. 2009 Nov 21; 54(22):N509-17.
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Brenner DJ, Elliston CD, Hall EJ, Paganetti H. Reduction of the secondary neutron dose in passively scattered proton radiotherapy, using an optimized pre-collimator/collimator. Phys Med Biol. 2009 Oct 21; 54(20):6065-78.
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Athar BS, Paganetti H. Neutron equivalent doses and associated lifetime cancer incidence risks for head & neck and spinal proton therapy. Phys Med Biol. 2009 Aug 21; 54(16):4907-26.
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Daartz J, Engelsman M, Paganetti H, Bussière MR. Field size dependence of the output factor in passively scattered proton therapy: influence of range, modulation, air gap, and machine settings. Med Phys. 2009 Jul; 36(7):3205-10.
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Knopf A, Parodi K, Bortfeld T, Shih HA, Paganetti H. Systematic analysis of biological and physical limitations of proton beam range verification with offline PET/CT scans. Phys Med Biol. 2009 Jul 21; 54(14):4477-95.
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Seco J, Robertson D, Trofimov A, Paganetti H. Breathing interplay effects during proton beam scanning: simulation and statistical analysis. Phys Med Biol. 2009 Jul 21; 54(14):N283-94.
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Paganetti H. Dose to water versus dose to medium in proton beam therapy. Phys Med Biol. 2009 Jul 21; 54(14):4399-421.
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Paganetti H, Goitein M, Parodi K. Spread-out antiproton beams deliver poor physical dose distributions for radiation therapy. Radiother Oncol. 2010 Apr; 95(1):79-86.
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Riboldi M, Chen GT, Baroni G, Paganetti H, Seco J. Design and testing of a simulation framework for dosimetric motion studies integrating an anthropomorphic computational phantom into four-dimensional Monte Carlo. Technol Cancer Res Treat. 2008 Dec; 7(6):449-56.
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Paganetti H, Jiang H, Parodi K, Slopsema R, Engelsman M. Clinical implementation of full Monte Carlo dose calculation in proton beam therapy. Phys Med Biol. 2008 Sep 7; 53(17):4825-53.
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Jarlskog CZ, Paganetti H. Sensitivity of different dose scoring methods on organ-specific neutron dose calculations in proton therapy. Phys Med Biol. 2008 Sep 7; 53(17):4523-32.
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Knopf A, Parodi K, Paganetti H, Cascio E, Bonab A, Bortfeld T. Quantitative assessment of the physical potential of proton beam range verification with PET/CT. Phys Med Biol. 2008 Aug 7; 53(15):4137-51.
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Zacharatou Jarlskog C, Paganetti H. Risk of developing second cancer from neutron dose in proton therapy as function of field characteristics, organ, and patient age. Int J Radiat Oncol Biol Phys. 2008 Sep 1; 72(1):228-35.
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Xu XG, Bednarz B, Paganetti H. A review of dosimetry studies on external-beam radiation treatment with respect to second cancer induction. Phys Med Biol. 2008 Jul 7; 53(13):R193-241.
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Suit H, Kooy H, Trofimov A, Farr J, Munzenrider J, DeLaney T, Loeffler J, Clasie B, Safai S, Paganetti H. Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No. Radiother Oncol. 2008 Feb; 86(2):148-53.
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Zacharatou Jarlskog C, Lee C, Bolch WE, Xu XG, Paganetti H. Assessment of organ-specific neutron equivalent doses in proton therapy using computational whole-body age-dependent voxel phantoms. Phys Med Biol. 2008 Feb 7; 53(3):693-717.
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Seco J, Sharp GC, Wu Z, Gierga D, Buettner F, Paganetti H. Dosimetric impact of motion in free-breathing and gated lung radiotherapy: a 4D Monte Carlo study of intrafraction and interfraction effects. Med Phys. 2008 Jan; 35(1):356-66.
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Paganetti H. The impact of protons on the incidence of second malignancies in radiotherapy by Eric J. Hall; Supp.31-34 2007. Technol Cancer Res Treat. 2007 Dec; 6(6):661-2.
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Parodi K, Paganetti H, Shih HA, Michaud S, Loeffler JS, DeLaney TF, Liebsch NJ, Munzenrider JE, Fischman AJ, Knopf A, Bortfeld T. Patient study of in vivo verification of beam delivery and range, using positron emission tomography and computed tomography imaging after proton therapy. Int J Radiat Oncol Biol Phys. 2007 Jul 1; 68(3):920-34.
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Parodi K, Ferrari A, Sommerer F, Paganetti H. Clinical CT-based calculations of dose and positron emitter distributions in proton therapy using the FLUKA Monte Carlo code. Phys Med Biol. 2007 Jun 21; 52(12):3369-87.
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Jiang H, Seco J, Paganetti H. Effects of Hounsfield number conversion on CT based proton Monte Carlo dose calculations. Med Phys. 2007 Apr; 34(4):1439-49.
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Seco J, Sharp GC, Turcotte J, Gierga D, Bortfeld T, Paganetti H. Effects of organ motion on IMRT treatments with segments of few monitor units. Med Phys. 2007 Mar; 34(3):923-34.
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Parodi K, Paganetti H, Cascio E, Flanz JB, Bonab AA, Alpert NM, Lohmann K, Bortfeld T. PET/CT imaging for treatment verification after proton therapy: a study with plastic phantoms and metallic implants. Med Phys. 2007 Feb; 34(2):419-35.
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Suit H, Goldberg S, Niemierko A, Ancukiewicz M, Hall E, Goitein M, Wong W, Paganetti H. Secondary carcinogenesis in patients treated with radiation: a review of data on radiation-induced cancers in human, non-human primate, canine and rodent subjects. Radiat Res. 2007 Jan; 167(1):12-42.
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Paganetti H, Bortfeld T, Delaney TF. Neutron dose in proton radiation therapy: in regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1-7). Int J Radiat Oncol Biol Phys. 2006 Dec 1; 66(5):1594-5; author reply 1595.
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Bortfeld T, Paganetti H. The biologic relevance of daily dose variations in adaptive treatment planning. Int J Radiat Oncol Biol Phys. 2006 Jul 1; 65(3):899-906.
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Paganetti H. Monte Carlo calculations for absolute dosimetry to determine machine outputs for proton therapy fields. Phys Med Biol. 2006 Jun 7; 51(11):2801-12.
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Kooy HM, Rosenthal SJ, Engelsman M, Mazal A, Slopsema RL, Paganetti H, Flanz JB. The prediction of output factors for spread-out proton Bragg peak fields in clinical practice. Phys Med Biol. 2005 Dec 21; 50(24):5847-56.
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Paganetti H. Changes in tumor cell response due to prolonged dose delivery times in fractionated radiation therapy. Int J Radiat Oncol Biol Phys. 2005 Nov 1; 63(3):892-900.
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Jiang H, Wang B, Xu XG, Suit HD, Paganetti H. Simulation of organ-specific patient effective dose due to secondary neutrons in proton radiation treatment. Phys Med Biol. 2005 Sep 21; 50(18):4337-53.
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Paganetti H. Interpretation of proton relative biological effectiveness using lesion induction, lesion repair, and cellular dose distribution. Med Phys. 2005 Aug; 32(8):2548-56.
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Paganetti H, Jiang H, Trofimov A. 4D Monte Carlo simulation of proton beam scanning: modelling of variations in time and space to study the interplay between scanning pattern and time-dependent patient geometry. Phys Med Biol. 2005 Mar 7; 50(5):983-90.
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Paganetti H, Jiang H, Adams JA, Chen GT, Rietzel E. Monte Carlo simulations with time-dependent geometries to investigate effects of organ motion with high temporal resolution. Int J Radiat Oncol Biol Phys. 2004 Nov 1; 60(3):942-50.
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Jiang H, Paganetti H. Adaptation of GEANT4 to Monte Carlo dose calculations based on CT data. Med Phys. 2004 Oct; 31(10):2811-8.
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Paganetti H, Jiang H, Lee SY, Kooy HM. Accurate Monte Carlo simulations for nozzle design, commissioning and quality assurance for a proton radiation therapy facility. Med Phys. 2004 Jul; 31(7):2107-18.
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Paganetti H. Four-dimensional Monte Carlo simulation of time-dependent geometries. Phys Med Biol. 2004 Mar 21; 49(6):N75-81.
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Flanz J, Paganetti H. Monte Carlo calculations in support of the commissioning of the Northeast Proton Therapy Center. Australas Phys Eng Sci Med. 2003 Dec; 26(4):156-61.
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Paganetti H. Foreword: Hadron therapy--from yesterday's physics laboratory to today's modern clinical routine. Technol Cancer Res Treat. 2003 Oct; 2(5):353-4.
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Paganetti H. Significance and implementation of RBE variations in proton beam therapy. Technol Cancer Res Treat. 2003 Oct; 2(5):413-26.
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Paganetti H, Gottschalk B. Test of GEANT3 and GEANT4 nuclear models for 160 MeV protons stopping in CH2. Med Phys. 2003 Jul; 30(7):1926-31.
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Suit H, Goldberg S, Niemierko A, Trofimov A, Adams J, Paganetti H, Chen GT, Bortfeld T, Rosenthal S, Loeffler J, Delaney T. Proton beams to replace photon beams in radical dose treatments. Acta Oncol. 2003; 42(8):800-8.
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Paganetti H, Niemierko A, Ancukiewicz M, Gerweck LE, Goitein M, Loeffler JS, Suit HD. Relative biological effectiveness (RBE) values for proton beam therapy. Int J Radiat Oncol Biol Phys. 2002 Jun 1; 53(2):407-21.
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Paganetti H. Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles. Phys Med Biol. 2002 Mar 7; 47(5):747-64.
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Paganetti H, Goitein M. Biophysical modelling of proton radiation effects based on amorphous track models. Int J Radiat Biol. 2001 Sep; 77(9):911-28.
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Paganetti H, Gerweck LE, Goitein M. The general relation between tissue response to x-radiation (alpha/beta-values) and the relative biological effectiveness (RBE) of protons: prediction by the Katz track-structure model. Int J Radiat Biol. 2000 Jul; 76(7):985-98.
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Paganetti H, Goitein M. Radiobiological significance of beamline dependent proton energy distributions in a spread-out Bragg peak. Med Phys. 2000 May; 27(5):1119-26.
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Gottschalk B, Platais R, Paganetti H. Nuclear interactions of 160 MeV protons stopping in copper: a test of Monte Carlo nuclear models. Med Phys. 1999 Dec; 26(12):2597-601.
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Paganetti H. Monte Carlo method to study the proton fluence for treatment planning. Med Phys. 1998 Dec; 25(12):2370-5.
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Paganetti H. Calculation of the spatial variation of relative biological effectiveness in a therapeutic proton field for eye treatment. Phys Med Biol. 1998 Aug; 43(8):2147-57.
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Paganetti H, Olko P, Kobus H, Becker R, Schmitz T, Waligorski MP, Filges D, Müller-Gärtner HW. Calculation of relative biological effectiveness for proton beams using biological weighting functions. Int J Radiat Oncol Biol Phys. 1997 Feb 1; 37(3):719-29.
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Paganetti H, Schmitz T. The influence of the beam modulation technique on dose and RBE in proton radiation therapy. Phys Med Biol. 1996 Sep; 41(9):1649-63.
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