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Last Name
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Robert O. Wright, M.D.

TitleAdjunct Professor of Environmental Health
InstitutionHarvard School of Public Health
DepartmentEH - Environmental + Occupational Medicine + Epi
AddressThe Channing Lab
181 Longwood Ave
Boston MA 02115
Phone617/384-8870
Fax617/384-8994
Other Positions
TitleVisiting Assistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine


 Mentoring 
 completed student projects
Total Occlusal Convergence of Crown Preparation Prepared by Dental Students and Prosthodontic Residents
Summer, 06/14/10 - 07/30/10

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Claus Henn B, Ettinger AS, Schwartz J, Téllez-Rojo MM, Lamadrid-Figueroa H, Hernández-Avila M, Schnaas L, Amarasiriwardena C, Bellinger DC, Hu H, Wright RO. Early postnatal blood manganese levels and children's neurodevelopment. Epidemiology. 2010 Jul; 21(4):433-9.
    View in: PubMed
  2. Pilsner JR, Hu H, Wright RO, Kordas K, Ettinger AS, Sánchez BN, Cantonwine D, Lazarus AL, Cantoral A, Schnaas L, Téllez-Rojo MM, Hernández-Avila M. Maternal MTHFR genotype and haplotype predict deficits in early cognitive development in a lead-exposed birth cohort in Mexico City. Am J Clin Nutr. 2010 Jul; 92(1):226-34.
    View in: PubMed
  3. Bouchard MF, Bellinger DC, Wright RO, Weisskopf MG. Attention-deficit/hyperactivity disorder and urinary metabolites of organophosphate pesticides. Pediatrics. 2010 Jun; 125(6):e1270-7.
    View in: PubMed
  4. Wright RO, Christiani D. Gene-environment interaction and children's health and development. Curr Opin Pediatr. 2010 Apr; 22(2):197-201.
    View in: PubMed
  5. Wilker EH, Baccarelli A, Suh H, Vokonas P, Wright RO, Schwartz J. Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes. Environ Health Perspect. 2010 Jul; 118(7):943-8.
    View in: PubMed
  6. Ren C, Park SK, Vokonas PS, Sparrow D, Wilker E, Baccarelli A, Suh HH, Tucker KL, Wright RO, Schwartz J. Air pollution and homocysteine: more evidence that oxidative stress-related genes modify effects of particulate air pollution. Epidemiology. 2010 Mar; 21(2):198-206.
    View in: PubMed
  7. Wright RO, Schwartz J, Wright RJ, Bollati V, Tarantini L, Park SK, Hu H, Sparrow D, Vokonas P, Baccarelli A. Biomarkers of lead exposure and DNA methylation within retrotransposons. Environ Health Perspect. 2010 Jun; 118(6):790-5.
    View in: PubMed
  8. Bouchard MF, Bellinger DC, Weuve J, Matthews-Bellinger J, Gilman SE, Wright RO, Schwartz J, Weisskopf MG. Blood lead levels and major depressive disorder, panic disorder, and generalized anxiety disorder in US young adults. Arch Gen Psychiatry. 2009 Dec; 66(12):1313-9.
    View in: PubMed
  9. Peters JL, Weisskopf MG, Spiro A, Schwartz J, Sparrow D, Nie H, Hu H, Wright RO, Wright RJ. Interaction of stress, lead burden, and age on cognition in older men: the VA Normative Aging Study. Environ Health Perspect. 2010 Apr; 118(4):505-10.
    View in: PubMed
  10. Madrigano J, Baccarelli A, Wright RO, Suh H, Sparrow D, Vokonas PS, Schwartz J. Air pollution, obesity, genes and cellular adhesion molecules. Occup Environ Med. 2010 May; 67(5):312-7.
    View in: PubMed
  11. Roy A, Hu H, Bellinger DC, Palaniapan K, Wright RO, Schwartz J, Balakrishnan K. Predictors of blood lead in children in Chennai, India (2005-2006). Int J Occup Environ Health. 2009 Oct-Dec; 15(4):351-9.
    View in: PubMed
  12. Mordukhovich I, Wright RO, Amarasiriwardena C, Baja E, Baccarelli A, Suh H, Sparrow D, Vokonas P, Schwartz J. Association between low-level environmental arsenic exposure and QT interval duration in a general population study. Am J Epidemiol. 2009 Sep 15; 170(6):739-46.
    View in: PubMed
  13. Roy A, Bellinger D, Hu H, Schwartz J, Ettinger AS, Wright RO, Bouchard M, Palaniappan K, Balakrishnan K. Lead exposure and behavior among young children in Chennai, India. Environ Health Perspect. 2009 Oct; 117(10):1607-11.
    View in: PubMed
  14. McQueen A, Wright RO, Kido MM, Kaye E, Krauss B. Procedural sedation and analgesia outcomes in children after discharge from the emergency department: ketamine versus fentanyl/midazolam. Ann Emerg Med. 2009 Aug; 54(2):191-97.e1-4.
    View in: PubMed
  15. Zota AR, Ettinger AS, Bouchard M, Amarasiriwardena CJ, Schwartz J, Hu H, Wright RO. Maternal blood manganese levels and infant birth weight. Epidemiology. 2009 May; 20(3):367-73.
    View in: PubMed
  16. Kordas K, Ettinger AS, Lamadrid-Figueroa H, Tellez-Rojo MM, Hérnandez-Avila M, Hu H, Wright RO. Methylenetetrahydrofolate reductase ( MTHFR) C677T, A1298C and G1793A genotypes, and the relationship between maternal folate intake, tibia lead and infant size at birth. Br J Nutr. 2009 Sep; 102(6):907-14.
    View in: PubMed
  17. Wright RO. New morbidities: new challenges. Curr Opin Pediatr. 2009 Apr; 21(2):220-1.
    View in: PubMed
  18. Pilsner JR, Hu H, Ettinger A, Sánchez BN, Wright RO, Cantonwine D, Lazarus A, Lamadrid-Figueroa H, Mercado-García A, Téllez-Rojo MM, Hernández-Avila M. Influence of prenatal lead exposure on genomic methylation of cord blood DNA. Environ Health Perspect. 2009 Sep; 117(9):1466-71.
    View in: PubMed
  19. Ettinger AS, Zota AR, Amarasiriwardena CJ, Hopkins MR, Schwartz J, Hu H, Wright RO. Maternal arsenic exposure and impaired glucose tolerance during pregnancy. Environ Health Perspect. 2009 Jul; 117(7):1059-64.
    View in: PubMed
  20. Wilker E, Mittleman MA, Litonjua AA, Poon A, Baccarelli A, Suh H, Wright RO, Sparrow D, Vokonas P, Schwartz J. Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter. Environ Health Perspect. 2009 Jun; 117(6):935-40.
    View in: PubMed
  21. Arora M, Weuve J, Schwartz J, Wright RO. Association of environmental cadmium exposure with periodontal disease in U.S. adults. Environ Health Perspect. 2009 May; 117(5):739-44.
    View in: PubMed
  22. Baccarelli A, Wright RO, Bollati V, Tarantini L, Litonjua AA, Suh HH, Zanobetti A, Sparrow D, Vokonas PS, Schwartz J. Rapid DNA methylation changes after exposure to traffic particles. Am J Respir Crit Care Med. 2009 Apr 1; 179(7):572-8.
    View in: PubMed
  23. Rajan P, Kelsey KT, Schwartz JD, Bellinger DC, Weuve J, Spiro A, Sparrow D, Smith TJ, Nie H, Weisskopf MG, Hu H, Wright RO. Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA normative aging study. J Occup Environ Med. 2008 Sep; 50(9):1053-61.
    View in: PubMed
  24. Hopkins MR, Ettinger AS, Hernández-Avila M, Schwartz J, Téllez-Rojo MM, Lamadrid-Figueroa H, Bellinger D, Hu H, Wright RO. Variants in iron metabolism genes predict higher blood lead levels in young children. Environ Health Perspect. 2008 Sep; 116(9):1261-6.
    View in: PubMed
  25. Park SK, Hu H, Wright RO, Schwartz J, Cheng Y, Sparrow D, Vokonas PS, Weisskopf MG. Iron metabolism genes, low-level lead exposure, and QT interval. Environ Health Perspect. 2009 Jan; 117(1):80-5.
    View in: PubMed
  26. Arora M, Weuve J, Schwartz J, Wright RO. Association of environmental cadmium exposure with pediatric dental caries. Environ Health Perspect. 2008 Jun; 116(6):821-5.
    View in: PubMed
  27. Wright RO, Fields N. Therapeutics and toxicology. Curr Opin Pediatr. 2008 Apr; 20(2):171.
    View in: PubMed
  28. Suglia SF, Wright RO, Schwartz J, Wright RJ. Association between lung function and cognition among children in a prospective birth cohort study. Psychosom Med. 2008 Apr; 70(3):356-62.
    View in: PubMed
  29. Oken E, Radesky JS, Wright RO, Bellinger DC, Amarasiriwardena CJ, Kleinman KP, Hu H, Gillman MW. Maternal fish intake during pregnancy, blood mercury levels, and child cognition at age 3 years in a US cohort. Am J Epidemiol. 2008 May 15; 167(10):1171-81.
    View in: PubMed
  30. Wright RO. Neurotoxicology: what can context teach us? J Pediatr. 2008 Feb; 152(2):155-7.
    View in: PubMed
  31. Park SK, O'Neill MS, Vokonas PS, Sparrow D, Wright RO, Coull B, Nie H, Hu H, Schwartz J. Air pollution and heart rate variability: effect modification by chronic lead exposure. Epidemiology. 2008 Jan; 19(1):111-20.
    View in: PubMed
  32. Arora M, Ettinger AS, Peterson KE, Schwartz J, Hu H, Hernández-Avila M, Tellez-Rojo MM, Wright RO. Maternal dietary intake of polyunsaturated fatty acids modifies the relationship between lead levels in bone and breast milk. J Nutr. 2008 Jan; 138(1):73-9.
    View in: PubMed
  33. Surkan PJ, Schnaas L, Wright RJ, Téllez-Rojo MM, Lamadrid-Figueroa H, Hu H, Hernández-Avila M, Bellinger DC, Schwartz J, Perroni E, Wright RO. Maternal self-esteem, exposure to lead, and child neurodevelopment. Neurotoxicology. 2008 Mar; 29(2):278-85.
    View in: PubMed
  34. Wright RO, Baccarelli A. Metals and neurotoxicology. J Nutr. 2007 Dec; 137(12):2809-13.
    View in: PubMed
  35. Chahine T, Baccarelli A, Litonjua A, Wright RO, Suh H, Gold DR, Sparrow D, Vokonas P, Schwartz J. Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort. Environ Health Perspect. 2007 Nov; 115(11):1617-22.
    View in: PubMed
  36. Lamadrid-Figueroa H, Téllez-Rojo MM, Hernández-Avila M, Trejo-Valdivia B, Solano-González M, Mercado-Garcia A, Smith D, Hu H, Wright RO. Association between the plasma/whole blood lead ratio and history of spontaneous abortion: a nested cross-sectional study. BMC Pregnancy Childbirth. 2007; 7:22.
    View in: PubMed
  37. Rajan P, Kelsey KT, Schwartz JD, Bellinger DC, Weuve J, Sparrow D, Spiro A, Smith TJ, Nie H, Hu H, Wright RO. Lead burden and psychiatric symptoms and the modifying influence of the delta-aminolevulinic acid dehydratase (ALAD) polymorphism: the VA Normative Aging Study. Am J Epidemiol. 2007 Dec 15; 166(12):1400-8.
    View in: PubMed
  38. Wang FT, Hu H, Schwartz J, Weuve J, Spiro AS, Sparrow D, Nie H, Silverman EK, Weiss ST, Wright RO. Modifying effects of the HFE polymorphisms on the association between lead burden and cognitive decline. Environ Health Perspect. 2007 Aug; 115(8):1210-5.
    View in: PubMed
  39. Peters JL, Kubzansky L, McNeely E, Schwartz J, Spiro A, Sparrow D, Wright RO, Nie H, Hu H. Stress as a potential modifier of the impact of lead levels on blood pressure: the normative aging study. Environ Health Perspect. 2007 Aug; 115(8):1154-9.
    View in: PubMed
  40. Jain NB, Potula V, Schwartz J, Vokonas PS, Sparrow D, Wright RO, Nie H, Hu H. Lead levels and ischemic heart disease in a prospective study of middle-aged and elderly men: the VA Normative Aging Study. Environ Health Perspect. 2007 Jun; 115(6):871-5.
    View in: PubMed
  41. Hu H, Shine J, Wright RO. The challenge posed to children's health by mixtures of toxic waste: the Tar Creek superfund site as a case-study. Pediatr Clin North Am. 2007 Feb; 54(1):155-75, x.
    View in: PubMed
  42. Weisskopf MG, Hu H, Sparrow D, Lenkinski RE, Wright RO. Proton magnetic resonance spectroscopic evidence of glial effects of cumulative lead exposure in the adult human hippocampus. Environ Health Perspect. 2007 Apr; 115(4):519-23.
    View in: PubMed
  43. Weisskopf MG, Proctor SP, Wright RO, Schwartz J, Spiro A, Sparrow D, Nie H, Hu H. Cumulative lead exposure and cognitive performance among elderly men. Epidemiology. 2007 Jan; 18(1):59-66.
    View in: PubMed
  44. Park SK, O'Neill MS, Wright RO, Hu H, Vokonas PS, Sparrow D, Suh H, Schwartz J. HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interaction. Circulation. 2006 Dec 19; 114(25):2798-805.
    View in: PubMed
  45. Park SK, Schwartz J, Weisskopf M, Sparrow D, Vokonas PS, Wright RO, Coull B, Nie H, Hu H. Low-level lead exposure, metabolic syndrome, and heart rate variability: the VA Normative Aging Study. Environ Health Perspect. 2006 Nov; 114(11):1718-24.
    View in: PubMed
  46. Chou K, Wright RO. Phthalates in food and medical devices. J Med Toxicol. 2006 Sep; 2(3):126-35.
    View in: PubMed
  47. Téllez-Rojo MM, Bellinger DC, Arroyo-Quiroz C, Lamadrid-Figueroa H, Mercado-García A, Schnaas-Arrieta L, Wright RO, Hernández-Avila M, Hu H. Longitudinal associations between blood lead concentrations lower than 10 microg/dL and neurobehavioral development in environmentally exposed children in Mexico City. Pediatrics. 2006 Aug; 118(2):e323-30.
    View in: PubMed
  48. Nagler J, Wright RO, Krauss B. End-tidal carbon dioxide as a measure of acidosis among children with gastroenteritis. Pediatrics. 2006 Jul; 118(1):260-7.
    View in: PubMed
  49. Weuve J, Kelsey KT, Schwartz J, Bellinger D, Wright RO, Rajan P, Spiro A, Sparrow D, Aro A, Hu H. Delta-aminolevulinic acid dehydratase polymorphism and the relation between low level lead exposure and the Mini-Mental Status Examination in older men: the Normative Aging Study. Occup Environ Med. 2006 Nov; 63(11):746-53.
    View in: PubMed
  50. Wright RO, Amarasiriwardena C, Woolf AD, Jim R, Bellinger DC. Neuropsychological correlates of hair arsenic, manganese, and cadmium levels in school-age children residing near a hazardous waste site. Neurotoxicology. 2006 Mar; 27(2):210-6.
    View in: PubMed
  51. Oken E, Wright RO, Kleinman KP, Bellinger D, Amarasiriwardena CJ, Hu H, Rich-Edwards JW, Gillman MW. Maternal fish consumption, hair mercury, and infant cognition in a U.S. Cohort. Environ Health Perspect. 2005 Oct; 113(10):1376-80.
    View in: PubMed
  52. Lanphear BP, Wright RO, Dietrich KN. Environmental neurotoxins. Pediatr Rev. 2005 Jun; 26(6):191-7; quiz 198.
    View in: PubMed
  53. Overly FL, Wright RO, Connor FA, Jay GD, Linakis JG. Bispectral analysis during deep sedation of pediatric oral surgery patients. J Oral Maxillofac Surg. 2005 Feb; 63(2):215-9.
    View in: PubMed
  54. Overly FL, Wright RO, Connor FA, Fontaine B, Jay G, Linakis JG. Bispectral analysis during pediatric procedural sedation. Pediatr Emerg Care. 2005 Jan; 21(1):6-11.
    View in: PubMed
  55. Weisskopf MG, Wright RO, Schwartz J, Spiro A, Sparrow D, Aro A, Hu H. Cumulative lead exposure and prospective change in cognition among elderly men: the VA Normative Aging Study. Am J Epidemiol. 2004 Dec 15; 160(12):1184-93.
    View in: PubMed
  56. Wright RJ, Finn P, Contreras JP, Cohen S, Wright RO, Staudenmayer J, Wand M, Perkins D, Weiss ST, Gold DR. Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy. J Allergy Clin Immunol. 2004 Jun; 113(6):1051-7.
    View in: PubMed
  57. Wright RO, Silverman EK, Schwartz J, Tsaih SW, Senter J, Sparrow D, Weiss ST, Aro A, Hu H. Association between hemochromatosis genotype and lead exposure among elderly men: the normative aging study. Environ Health Perspect. 2004 May; 112(6):746-50.
    View in: PubMed
  58. Weisskopf MG, Hu H, Mulkern RV, White R, Aro A, Oliveira S, Wright RO. Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning. Environ Health Perspect. 2004 Apr; 112(5):620-5.
    View in: PubMed
  59. Amato CS, Wang RY, Wright RO, Linakis JG. Evaluation of promotility agents to limit the gut bioavailability of extended-release acetaminophen. J Toxicol Clin Toxicol. 2004; 42(1):73-7.
    View in: PubMed
  60. Wright RO, Tsaih SW, Schwartz J, Spiro A, McDonald K, Weiss ST, Hu H. Lead exposure biomarkers and mini-mental status exam scores in older men. Epidemiology. 2003 Nov; 14(6):713-8.
    View in: PubMed
  61. Wright RO, Hu H, Silverman EK, Tsaih SW, Schwartz J, Bellinger D, Palazuelos E, Weiss ST, Hernandez-Avila M. Apolipoprotein E genotype predicts 24-month bayley scales infant development score. Pediatr Res. 2003 Dec; 54(6):819-25.
    View in: PubMed
  62. Wright RO, Tsaih SW, Schwartz J, Wright RJ, Hu H. Association between iron deficiency and blood lead level in a longitudinal analysis of children followed in an urban primary care clinic. J Pediatr. 2003 Jan; 142(1):9-14.
    View in: PubMed
  63. Wright RJ, Wright RO, Farnan L, Isaac NE. Response to child abuse in the pediatric emergency department: need for continued education. Pediatr Emerg Care. 1999 Dec; 15(6):376-82.
    View in: PubMed
  64. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: etiology, pharmacology, and clinical management. Ann Emerg Med. 1999 Nov; 34(5):646-56.
    View in: PubMed
  65. Wright RO, Shannon MW, Wright RJ, Hu H. Association between iron deficiency and low-level lead poisoning in an urban primary care clinic. Am J Public Health. 1999 Jul; 89(7):1049-53.
    View in: PubMed
  66. Wright RO. The role of iron therapy in childhood plumbism. Curr Opin Pediatr. 1999 Jun; 11(3):255-8.
    View in: PubMed
  67. Wright RO, Anderson AC, Lesko SL, Woolf AD, Linakis JG, Lewander WJ. Effect of metoclopramide dose on preventing emesis after oral administration of N-acetylcysteine for acetaminophen overdose. J Toxicol Clin Toxicol. 1999; 37(1):35-42.
    View in: PubMed
  68. Wright RO, Hu H, Maher TJ, Amarasiriwardena C, Chaiyakul P, Woolf AD, Shannon MW. Effect of iron deficiency anemia on lead distribution after intravenous dosing in rats. Toxicol Ind Health. 1998 Jul-Aug; 14(4):547-51.
    View in: PubMed
  69. Perry HE, Wright RO, Shannon MW, Woolf AD. Baclofen overdose: drug experimentation in a group of adolescents. Pediatrics. 1998 Jun; 101(6):1045-8.
    View in: PubMed
  70. Wright RO. Pulse oximetry gap in carbon monoxide poisoning. Ann Emerg Med. 1998 Apr; 31(4):525-6.
    View in: PubMed
  71. Wright RO, Woolf AD, Shannon MW, Magnani B. N-acetylcysteine reduces methemoglobin in an in-vitro model of glucose-6-phosphate dehydrogenase deficiency. Acad Emerg Med. 1998 Mar; 5(3):225-9.
    View in: PubMed
  72. Steele DW, Santucci KA, Wright RO, Natarajan R, McQuillen KK, Jay GD. Pulsus paradoxus: an objective measure of severity in croup. Am J Respir Crit Care Med. 1998 Jan; 157(1):331-4.
    View in: PubMed
  73. Handrigan MT, Wright RO, Becker BM, Linakis JG, Jay GD. Factors and methodology in achieving ideal delivery temperatures for intravenous and lavage fluid in hypothermia. Am J Emerg Med. 1997 Jul; 15(4):350-3.
    View in: PubMed
  74. Wright RJ, Wright RO, Isaac NE. Response to battered mothers in the pediatric emergency department: a call for an interdisciplinary approach to family violence. Pediatrics. 1997 Feb; 99(2):186-92.
    View in: PubMed
  75. Wright RO, Santucci KA, Jay GD, Steele DW. Evaluation of pre- and posttreatment pulse oximetry in acute childhood asthma. Acad Emerg Med. 1997 Feb; 4(2):114-7.
    View in: PubMed
  76. Wright RO, Magnani B, Shannon MW, Woolf AD. N-acetylcysteine reduces methemoglobin in vitro. Ann Emerg Med. 1996 Nov; 28(5):499-503.
    View in: PubMed
  77. Wright RO, Steele DW, Santucci KA, Natarajan R, Jay GD. Continuous, noninvasive measurement of pulsus paradoxus in patients with acute asthma. Arch Pediatr Adolesc Med. 1996 Sep; 150(9):914-8.
    View in: PubMed
  78. Wright RO, Perry HE, Woolf AD, Shannon MW. Hemolysis after acetaminophen overdose in a patient with glucose-6-phosphate dehydrogenase deficiency. J Toxicol Clin Toxicol. 1996; 34(6):731-4.
    View in: PubMed
  79. Steele DW, Wright RO, Lee CM, Jay GD. Continuous noninvasive determination of pulsus paradoxus: a pilot study. Acad Emerg Med. 1995 Oct; 2(10):894-900.
    View in: PubMed
  80. Wright RO, Jay GD, Becker BM, Linakis JG. Use of infrared thermometry to measure lavage and intravenous fluid temperature. Am J Emerg Med. 1995 May; 13(3):281-4.
    View in: PubMed
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