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Hesheng Liu, Ph.D.

TitleAssistant Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
Radiology, Rm. 2301
149 13th Street
Charlestown MA 02129

 Biography 
 awards and honors
2011 - 2016K25 Mentored Quantitative Research Career Development Award
2013 - 2015NARSAD Young Investigator Award

 Overview 
 overview
My research focused on multi-modal imaging aimed at understanding individual differences. One major goal of my work is to improve surgical planning for epilepsy and brain tumor patients. Another goal is to develop imaging biomarkers that will enable identification of novel genetic variants associated with risk of psychiatric illness.

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Lab Website: nmr.mgh.harvard.edu/bid
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 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zeng L, Wang D, Fox MD, Sabuncu M, Hu D, Ge M, Buckner RL, Liu H. A Neurobiological Basis of Head Motion in Brain Imaging. . Proc Natl Acad Sci U S A. (in press) . 2014.
  2. Ge M, Wang D, Dong G, Guo B, Gao R, Sun W, Zhang J, Liu H. Transient impact of spike on theta rhythm in temporal lobe epilepsy. Exp Neurol. 2013 Dec; 250:136-42.
    View in: PubMed
  3. Qian T, Zhou W, Ling Z, Gao S, Liu H, Hong B. Fast presurgical functional mapping using task-related intracranial high gamma activity. J Neurosurg. 2013 Jul; 119(1):26-36.
    View in: PubMed
  4. Mueller S, Wang D, Fox MD, Yeo BT, Sepulcre J, Sabuncu MR, Shafee R, Lu J, Liu H. Individual variability in functional connectivity architecture of the human brain. Neuron. 2013 Feb 6; 77(3):586-95.
    View in: PubMed
  5. Fox MD, Liu H, Pascual-Leone A. Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity. Neuroimage. 2013; 66:151-160.
  6. Gallagher A, Tanaka N, Suzuki N, Liu H, Thiele EA, Stufflebeam SM. Diffuse cerebral language representation in tuberous sclerosis complex. Epilepsy Res. 2013 Mar; 104(1-2):125-33.
    View in: PubMed
  7. Wang D, Buckner RL, Liu H. Cerebellar asymmetry and its relation to cerebral asymmetry estimated by intrinsic functional connectivity. J Neurophysiol. 2013 Jan; 109(1):46-57.
    View in: PubMed
  8. Gallagher A, Tanaka N, Suzuki N, Liu H, Thiele EA, Stufflebeam SM. Decreased language laterality in tuberous sclerosis complex: a relationship between language dominance and tuber location as well as history of epilepsy. Epilepsy Behav. 2012 Sep; 25(1):36-41.
    View in: PubMed
  9. Tanaka N, Liu H, Reinsberger C, Madsen JR, Bourgeois BF, Dworetzky BA, Hämäläinen MS, Stufflebeam SM. Language lateralization represented by spatiotemporal mapping of magnetoencephalography. AJNR Am J Neuroradiol. 2013 Mar; 34(3):558-63.
    View in: PubMed
  10. Sepulcre J, Sabuncu MR, Yeo TB, Liu H, Johnson KA. Stepwise connectivity of the modal cortex reveals the multimodal organization of the human brain. J Neurosci. 2012 Aug 1; 32(31):10649-61.
    View in: PubMed
  11. Fang J, Wang X, Liu H, Wang Y, Zhou K, Hong Y, Liu J, Wang L, Xue C, Song M, Liu B, Zhu B. The Limbic-Prefrontal Network Modulated by Electroacupuncture at CV4 and CV12. Evid Based Complement Alternat Med. 2012; 2012:515893.
    View in: PubMed
  12. Lu J*, Liu H*, Zhang M, Wang D, Cao Y, Ma Q, Rong D, Wang X, Buckner RL, Li K. . Focal pontine lesions provide evidence that intrinsic functional connectivity reflects polysynaptic anatomical pathways. J Neurosci. 2011; 42(31):15065-71.
  13. Sabuncu MR, Desikan RS, Sepulcre J, Yeo BT, Liu H, Schmansky NJ, Reuter M, Weiner MW, Buckner RL, Sperling RA, Fischl B. The dynamics of cortical and hippocampal atrophy in Alzheimer disease. Arch Neurol. 2011 Aug; 68(8):1040-8.
    View in: PubMed
  14. Yeo BT, Krienen FM, Sepulcre J, Sabuncu MR, Lashkari D, Hollinshead M, Roffman JL, Smoller JW, Zöllei L, Polimeni JR, Fischl B, Liu H, Buckner RL. The organization of the human cerebral cortex estimated by intrinsic functional connectivity. J Neurophysiol. 2011 Sep; 106(3):1125-65.
    View in: PubMed
  15. Stufflebeam SM, Liu H, Sepulcre J, Tanaka N, Buckner RL, Madsen JR. Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. J Neurosurg. 2011 Jun; 114(6):1693-7.
    View in: PubMed
  16. Liu H, Tanaka N, Stufflebeam S, Ahlfors S, Hämäläinen M. Functional Mapping with Simultaneous MEG and EEG. J Vis Exp. 2010; (40).
    View in: PubMed
  17. Sepulcre J, Liu H, Talukdar T, Martincorena I, Yeo BT, Buckner RL. The organization of local and distant functional connectivity in the human brain. PLoS Comput Biol. 2010 Jun; 6(6):e1000808.
    View in: PubMed
  18. Agam Y, Liu H, Papanastassiou A, Buia C, Golby AJ, Madsen JR, Kreiman G. Robust selectivity to two-object images in human visual cortex. Curr Biol. 2010 May 11; 20(9):872-9.
    View in: PubMed
  19. Tanaka N, Hämäläinen MS, Ahlfors SP, Liu H, Madsen JR, Bourgeois BF, Lee JW, Dworetzky BA, Belliveau JW, Stufflebeam SM. Propagation of epileptic spikes reconstructed from spatiotemporal magnetoencephalographic and electroencephalographic source analysis. Neuroimage. 2010 Mar; 50(1):217-22.
    View in: PubMed
  20. Liu H, Stufflebeam SM, Sepulcre J, Hedden T, Buckner RL. Evidence from intrinsic activity that asymmetry of the human brain is controlled by multiple factors. Proc Natl Acad Sci U S A. 2009 Dec 1; 106(48):20499-503.
    View in: PubMed
  21. Liu H, Buckner RL, Talukdar T, Tanaka N, Madsen JR, Stufflebeam SM. Task-free presurgical mapping using functional magnetic resonance imaging intrinsic activity. J Neurosurg. 2009 Oct; 111(4):746-54.
    View in: PubMed
  22. Liu H, Agam Y, Madsen JR, Kreiman G. Timing, timing, timing: fast decoding of object information from intracranial field potentials in human visual cortex. Neuron. 2009 Apr 30; 62(2):281-90.
    View in: PubMed
  23. Tanaka N, Cole AJ, von Pechmann D, Wakeman DG, Hämäläinen MS, Liu H, Madsen JR, Bourgeois BF, Stufflebeam SM. Dynamic statistical parametric mapping for analyzing ictal magnetoencephalographic spikes in patients with intractable frontal lobe epilepsy. Epilepsy Res. 2009 Aug; 85(2-3):279-86.
    View in: PubMed
  24. Buckner RL, Sepulcre J, Talukdar T, Krienen FM, Liu H, Hedden T, Andrews-Hanna JR, Sperling RA, Johnson KA. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. J Neurosci. 2009 Feb 11; 29(6):1860-73.
    View in: PubMed
  25. Wetterling F, Liehr M, Schimpf P, Liu H, Haueisen J. Physics in medicine and biology. The localization of focal heart activity via body surface potential measurements: tests in a heterogeneous torso phantom. 2009; (54):5395.
  26. LR Vandervert, PH Schimpf, H Liu. Creativity Research Journal. How working memory and the cerebellum collaborate to produce creativity and innovation. 2007; 1(19):1-18.
  27. Liu H, Schimpf PH. Efficient localization of synchronous EEG source activities using a modified RAP-MUSIC algorithm. IEEE Trans Biomed Eng. 2006 Apr; 53(4):652-61.
    View in: PubMed
  28. Liu H, Schimpf PH, Dong G, Gao X, Yang F, Gao S. Standardized shrinking LORETA-FOCUSS (SSLOFO): a new algorithm for spatio-temporal EEG source reconstruction. IEEE Trans Biomed Eng. 2005 Oct; 52(10):1681-91.
    View in: PubMed
  29. Schimpf PH, Liu H, Ramon C, Haueisen J. Efficient electromagnetic source imaging with adaptive standardized LORETA/FOCUSS. IEEE Trans Biomed Eng. 2005 May; 52(5):901-8.
    View in: PubMed
  30. Dong G, Liu H, Bayford RH, Yerworth R, Schimpf PH, Yan W. Spatial resolution improvement of 3D EIT images by the shrinking sLORETA-FOCUSS algorithm. Physiol Meas. 2005 Apr; 26(2):S199-208.
    View in: PubMed
  31. Liu H, Gao X, Schimpf PH, Yang F, Gao S. A recursive algorithm for the three-dimensional imaging of brain electric activity: Shrinking LORETA-FOCUSS. IEEE Trans Biomed Eng. 2004 Oct; 51(10):1794-802.
    View in: PubMed
  32. Li Y, Gao X, Liu H, Gao S. Classification of single-trial electroencephalogram during finger movement. IEEE Trans Biomed Eng. 2004 Jun; 51(6):1019-25.
    View in: PubMed
  33. Dong G, Liu H, Bayford RH, Yerworth R, Gao S, Holder D, Yan W. The spatial resolution improvement of EIT images by GVSPM-FOCUSS algorithm. Physiol Meas. 2004 Feb; 25(1):209-25.
    View in: PubMed
  34. Liu HS, Zhang T, Yang FS. A multistage, multimethod approach for automatic detection and classification of epileptiform EEG. IEEE Trans Biomed Eng. 2002 Dec; 49(12 Pt 2):1557-66.
    View in: PubMed
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