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Last Name
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David E. Sosnovik, M.D.

TitleAssistant Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Bldg 149, 5416, CMIR
149 13th Street
Charlestown MA 02129
Phone617/726-2980
Other Positions
TitleMember of the Affiliated Faculty of the Harvard-MIT Division of Health Sciences and Technology
InstitutionHarvard Medical School
DepartmentHealth Sciences and Technology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Chen C, Feng Y, Zou L, Wang L, Chen HH, Cai JY, Xu JM, Sosnovik DE, Chao W. Role of Extracellular RNA and TLR3-Trif Signaling in Myocardial Ischemia-Reperfusion Injury. J Am Heart Assoc. 2014; 3(1):e000683.
    View in: PubMed
  2. Caravan P, Yang Y, Zachariah R, Schmitt A, Mino-Kenudson M, Chen HH, Sosnovik DE, Dai G, Fuchs BC, Lanuti M. Molecular magnetic resonance imaging of pulmonary fibrosis in mice. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):1120-6.
    View in: PubMed
  3. Yuan H, Cho H, Chen HH, Panagia M, Sosnovik DE, Josephson L. Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria. Chem Commun (Camb). 2013 Oct 10; 49(88):10361-3.
    View in: PubMed
  4. Mekkaoui C, Porayette P, Jackowski MP, Kostis WJ, Dai G, Sanders S, Sosnovik DE. Diffusion MRI tractography of the developing human fetal heart. PLoS One. 2013; 8(8):e72795.
    View in: PubMed
  5. Cho H, Guo Y, Sosnovik DE, Josephson L. Imaging DNA with fluorochrome bearing metals. Inorg Chem. 2013 Nov 4; 52(21):12216-22.
    View in: PubMed
  6. Chen HH, Mekkaoui C, Cho H, Ngoy S, Marinelli B, Waterman P, Nahrendorf M, Liao R, Josephson L, Sosnovik DE. Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo. Circ Cardiovasc Imaging. 2013 May 1; 6(3):441-7.
    View in: PubMed
  7. Károlyi M, Seifarth H, Liew G, Schlett CL, Maurovich-Horvat P, Stolzmann P, Dai G, Huang S, Goergen CJ, Nakano M, Otsuka F, Virmani R, Hoffmann U, Sosnovik DE. Classification of Coronary Atherosclerotic Plaques Ex Vivo With T1, T2, and Ultrashort Echo Time CMR. JACC Cardiovasc Imaging. 2013 Apr; 6(4):466-74.
    View in: PubMed
  8. Cho H, Alcantara D, Yuan H, Sheth RA, Chen HH, Huang P, Andersson SB, Sosnovik DE, Mahmood U, Josephson L. Fluorochrome-functionalized nanoparticles for imaging DNA in biological systems. ACS Nano. 2013 Mar 26; 7(3):2032-41.
    View in: PubMed
  9. McGill LA, Ismail TF, Nielles-Vallespin S, Ferreira P, Scott AD, Roughton M, Kilner PJ, Ho SY, McCarthy KP, Gatehouse PD, de Silva R, Speier P, Feiweier T, Mekkaoui C, Sosnovik DE, Prasad SK, Firmin DN, Pennell DJ. Reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy. J Cardiovasc Magn Reson. 2012; 14:86.
    View in: PubMed
  10. Bauer M, Kang L, Qiu Y, Wu J, Peng M, Chen HH, Camci-Unal G, Bayomy AF, Sosnovik DE, Khademhosseini A, Liao R. Adult cardiac progenitor cell aggregates exhibit survival benefit both in vitro and in vivo. PLoS One. 2012; 7(11):e50491.
    View in: PubMed
  11. Mekkaoui C, Huang S, Chen HH, Dai G, Reese TG, Kostis WJ, Thiagalingam A, Maurovich-Horvat P, Ruskin JN, Hoffmann U, Jackowski MP, Sosnovik DE. Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation. J Cardiovasc Magn Reson. 2012; 14:70.
    View in: PubMed
  12. Nielles-Vallespin S, Mekkaoui C, Gatehouse P, Reese TG, Keegan J, Ferreira PF, Collins S, Speier P, Feiweier T, de Silva R, Jackowski MP, Pennell DJ, Sosnovik DE, Firmin D. In vivo diffusion tensor MRI of the human heart: Reproducibility of breath-hold and navigator-based approaches. Magn Reson Med. 2013 Aug; 70(2):454-65.
    View in: PubMed
  13. Goergen CJ, Radhakrishnan H, Sakadžic S, Mandeville ET, Lo EH, Sosnovik DE, Srinivasan VJ. Optical coherence tractography using intrinsic contrast. Opt Lett. 2012 Sep 15; 37(18):3882-4.
    View in: PubMed
  14. Sosnovik DE, Nahrendorf M. Cells and iron oxide nanoparticles on the move: magnetic resonance imaging of monocyte homing and myocardial inflammation in patients with ST-elevation myocardial infarction. Circ Cardiovasc Imaging. 2012 Sep 1; 5(5):551-4.
    View in: PubMed
  15. Sosnovik DE, Nahrendorf M, Caravan P. Science to practice: how will myocardial inflammation be imaged with MR imaging? Radiology. 2012 Aug; 264(2):309-11.
    View in: PubMed
  16. Alcantara D, Guo Y, Yuan H, Goergen CJ, Chen HH, Cho H, Sosnovik DE, Josephson L. Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance. Angew Chem Int Ed Engl. 2012 Jul 9; 51(28):6904-7.
    View in: PubMed
  17. Goergen CJ, Chen HH, Bogdanov A, Sosnovik DE, Kumar AT. In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium. J Biomed Opt. 2012 May; 17(5):056001.
    View in: PubMed
  18. Chen HH, Yuan H, Josephson L, Sosnovik DE. Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival. Theranostics. 2012; 2(2):148-55.
    View in: PubMed
  19. Huang S, Chen HH, Yuan H, Dai G, Schuhle DT, Mekkaoui C, Ngoy S, Liao R, Caravan P, Josephson L, Sosnovik DE. Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium. Circ Cardiovasc Imaging. 2011 Nov; 4(6):729-37.
    View in: PubMed
  20. Nahrendorf M, Sosnovik DE. Science to practice: will magnetic guidance of microbubbles play a role in clinical molecular imaging? Radiology. 2011 Aug; 260(2):309-10.
    View in: PubMed
  21. Li Y, Si R, Feng Y, Chen HH, Zou L, Wang E, Zhang M, Warren HS, Sosnovik DE, Chao W. Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4. J Biol Chem. 2011 Sep 9; 286(36):31308-19.
    View in: PubMed
  22. Chen HH, Feng Y, Zhang M, Chao W, Josephson L, Shaw SY, Sosnovik DE. Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5. Nanomedicine. 2012 Apr; 8(3):291-8.
    View in: PubMed
  23. Goergen CJ, Sosnovik DE. From molecules to myofibers: multiscale imaging of the myocardium. J Cardiovasc Transl Res. 2011 Aug; 4(4):493-503.
    View in: PubMed
  24. Berry NC, Sosnovik DE. Cardiomyocyte death: insights from molecular and microstructural magnetic resonance imaging. Pediatr Cardiol. 2011 Mar; 32(3):290-6.
    View in: PubMed
  25. Chen HH, Josephson L, Sosnovik DE. Imaging of apoptosis in the heart with nanoparticle technology. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Jan-Feb; 3(1):86-99.
    View in: PubMed
  26. Leuschner F, Panizzi P, Chico-Calero I, Lee WW, Ueno T, Cortez-Retamozo V, Waterman P, Gorbatov R, Marinelli B, Iwamoto Y, Chudnovskiy A, Figueiredo JL, Sosnovik DE, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M. Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circ Res. 2010 Nov 26; 107(11):1364-73.
    View in: PubMed
  27. Kramer CM, Sinusas AJ, Sosnovik DE, French BA, Bengel FM. Multimodality imaging of myocardial injury and remodeling. J Nucl Med. 2010 May 1; 51 Suppl 1:107S-121S.
    View in: PubMed
  28. Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M. Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol. 2010 Apr 13; 55(15):1629-38.
    View in: PubMed
  29. Sosnovik DE, Wang R, Dai G, Reese TG, Wedeen VJ. Diffusion MR tractography of the heart. J Cardiovasc Magn Reson. 2009; 11:47.
    View in: PubMed
  30. Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L. Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia. Circ Cardiovasc Imaging. 2009 Nov; 2(6):460-7.
    View in: PubMed
  31. Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A. Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circ Cardiovasc Imaging. 2009 Nov; 2(6):468-75.
    View in: PubMed
  32. Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L. A DNA-binding Gd chelate for the detection of cell death by MRI. Chem Commun (Camb). 2009 Aug 7; (29):4444-6.
    View in: PubMed
  33. Figueiredo JL, Nahrendorf M, Sosnovik DE, Weissleder R. MRI of a novel murine working heart transplant model. Circ Heart Fail. 2009 May; 2(3):272-4.
    View in: PubMed
  34. Sosnovik DE. Will molecular MR imaging play a role in identification and treatment of patients with vulnerable atherosclerotic plaques? Radiology. 2009 May; 251(2):309-10.
    View in: PubMed
  35. Sosnovik DE, Wang R, Dai G, Wang T, Aikawa E, Novikov M, Rosenzweig A, Gilbert RJ, Wedeen VJ. Diffusion spectrum MRI tractography reveals the presence of a complex network of residual myofibers in infarcted myocardium. Circ Cardiovasc Imaging. 2009 May; 2(3):206-12.
    View in: PubMed
  36. Nahrendorf M, Sosnovik DE, French BA, Swirski FK, Bengel F, Sadeghi MM, Lindner JR, Wu JC, Kraitchman DL, Fayad ZA, Sinusas AJ. Multimodality cardiovascular molecular imaging, Part II. Circ Cardiovasc Imaging. 2009 Jan; 2(1):56-70.
    View in: PubMed
  37. Korosoglou G, Shah S, Vonken EJ, Gilson WD, Schär M, Tang L, Kraitchman DL, Boston RC, Sosnovik DE, Weiss RG, Weissleder R, Stuber M. Off-resonance angiography: a new method to depict vessels--phantom and rabbit studies. Radiology. 2008 Nov; 249(2):501-9.
    View in: PubMed
  38. Korosoglou G, Weiss RG, Kedziorek DA, Walczak P, Gilson WD, Schär M, Sosnovik DE, Kraitchman DL, Boston RC, Bulte JW, Weissleder R, Stuber M. Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using "positive contrast" magnetic resonance imaging. J Am Coll Cardiol. 2008 Aug 5; 52(6):483-91.
    View in: PubMed
  39. Sosnovik DE, Nahrendorf M, Weissleder R. Targeted imaging of myocardial damage. Nat Clin Pract Cardiovasc Med. 2008 Aug; 5 Suppl 2:S63-70.
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  40. Schmitt M, Potthast A, Sosnovik DE, Polimeni JR, Wiggins GC, Triantafyllou C, Wald LL. A 128-channel receive-only cardiac coil for highly accelerated cardiac MRI at 3 Tesla. Magn Reson Med. 2008 Jun; 59(6):1431-9.
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  41. Farrar CT, Dai G, Novikov M, Rosenzweig A, Weissleder R, Rosen BR, Sosnovik DE. Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging. NMR Biomed. 2008 Jun; 21(5):453-63.
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  42. Korngold EC, Jaffer FA, Weissleder R, Sosnovik DE. Noninvasive imaging of apoptosis in cardiovascular disease. Heart Fail Rev. 2008 Jun; 13(2):163-73.
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  43. Korosoglou G, Tang L, Kedziorek D, Cosby K, Gilson WD, Vonken EJ, Schär M, Sosnovik D, Kraitchman DL, Weiss RG, Weissleder R, Stuber M. Positive contrast MR-lymphography using inversion recovery with ON-resonant water suppression (IRON). J Magn Reson Imaging. 2008 May; 27(5):1175-80.
    View in: PubMed
  44. Sosnovik DE, Nahrendorf M, Weissleder R. Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications. Basic Res Cardiol. 2008 Mar; 103(2):122-30.
    View in: PubMed
  45. Nahrendorf M, Sosnovik DE, Weissleder R. MR-optical imaging of cardiovascular molecular targets. Basic Res Cardiol. 2008 Mar; 103(2):87-94.
    View in: PubMed
  46. Nahrendorf M, Sosnovik D, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R. Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury. Circulation. 2008 Mar 4; 117(9):1153-60.
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  47. Sosnovik DE. Molecular imaging in cardiovascular magnetic resonance imaging: current perspective and future potential. Top Magn Reson Imaging. 2008 Feb; 19(1):59-68.
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  48. Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne SW, Blankesteijn WM, Sosnovik DE, Jaffer FA, Tung CH, Weissleder R. Transglutaminase activity in acute infarcts predicts healing outcome and left ventricular remodelling: implications for FXIII therapy and antithrombin use in myocardial infarction. Eur Heart J. 2008 Feb; 29(4):445-54.
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  49. Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik DE, Aikawa E, Libby P, Swirski FK, Weissleder R. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation. 2008 Jan 22; 117(3):379-87.
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  50. Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L. Multiparameter magnetic relaxation switch assays. Anal Chem. 2007 Dec 1; 79(23):8863-9.
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  51. Sosnovik DE, Dai G, Nahrendorf M, Rosen BR, Seethamraju R. Cardiac MRI in mice at 9.4 Tesla with a transmit-receive surface coil and a cardiac-tailored intensity-correction algorithm. J Magn Reson Imaging. 2007 Aug; 26(2):279-87.
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  52. Sosnovik DE, Nahrendorf M, Weissleder R. Molecular magnetic resonance imaging in cardiovascular medicine. Circulation. 2007 Apr 17; 115(15):2076-86.
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  53. Nahrendorf M, Sosnovik DE, Waterman P, Swirski FK, Pande AN, Aikawa E, Figueiredo JL, Pittet MJ, Weissleder R. Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circ Res. 2007 Apr 27; 100(8):1218-25.
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  54. Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation. 2007 Mar 20; 115(11):1384-91.
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  55. Nahrendorf M, Badea C, Hedlund LW, Figueiredo JL, Sosnovik DE, Johnson GA, Weissleder R. High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT. Am J Physiol Heart Circ Physiol. 2007 Jun; 292(6):H3172-8.
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  56. Abbara S, Pena AJ, Maurovich-Horvat P, Butler J, Sosnovik DE, Lembcke A, Cury RC, Hoffmann U, Ferencik M, Brady TJ. Feasibility and optimization of aortic valve planimetry with MDCT. AJR Am J Roentgenol. 2007 Feb; 188(2):356-60.
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  57. Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation. 2007 Jan 23; 115(3):377-86.
    View in: PubMed
  58. Sosnovik DE, Weissleder R. Emerging concepts in molecular MRI. Curr Opin Biotechnol. 2007 Feb; 18(1):4-10.
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  59. Jaffer FA, Sosnovik DE, Nahrendorf M, Weissleder R. Molecular imaging of myocardial infarction. J Mol Cell Cardiol. 2006 Dec; 41(6):921-33.
    View in: PubMed
  60. Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation. 2006 Oct 3; 114(14):1504-11.
    View in: PubMed
  61. Jaffer FA, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R. Cellular imaging of inflammation in atherosclerosis using magnetofluorescent nanomaterials. Mol Imaging. 2006 Apr-Jun; 5(2):85-92.
    View in: PubMed
  62. Nahrendorf M, Hu K, Frantz S, Jaffer FA, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlöhner S, Novikov M, Dickneite G, Reed GL, Jakob P, Rosenzweig A, Bauer WR, Weissleder R, Ertl G. Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction. Circulation. 2006 Mar 7; 113(9):1196-202.
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  63. Nahrendorf M, Streif JU, Hiller KH, Hu K, Nordbeck P, Ritter O, Sosnovik D, Bauer L, Neubauer S, Jakob PM, Ertl G, Spindler M, Bauer WR. Multimodal functional cardiac MRI in creatine kinase-deficient mice reveals subtle abnormalities in myocardial perfusion and mechanics. Am J Physiol Heart Circ Physiol. 2006 Jun; 290(6):H2516-21.
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  64. Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med. 2005 Sep; 54(3):718-24.
    View in: PubMed
  65. Baldwin SL, Holland MR, Sosnovik DE, Miller JG. Effects of region-of-interest length on estimates of myocardial ultrasonic attenuation and backscatter. Med Phys. 2005 Feb; 32(2):418-26.
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  66. Sosnovik D, Weissleder R. Magnetic resonance and fluorescence based molecular imaging technologies. Prog Drug Res. 2005; 62:83-115.
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  67. Schellenberger EA, Sosnovik D, Weissleder R, Josephson L. Magneto/optical annexin V, a multimodal protein. Bioconjug Chem. 2004 Sep-Oct; 15(5):1062-7.
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  68. Hoffmann U, Millea R, Enzweiler C, Ferencik M, Gulick S, Titus J, Achenbach S, Kwait D, Sosnovik D, Brady TJ. Acute myocardial infarction: contrast-enhanced multi-detector row CT in a porcine model. Radiology. 2004 Jun; 231(3):697-701.
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  69. Mansour M, Holmvang G, Sosnovik D, Migrino R, Abbara S, Ruskin J, Keane D. Assessment of pulmonary vein anatomic variability by magnetic resonance imaging: implications for catheter ablation techniques for atrial fibrillation. J Cardiovasc Electrophysiol. 2004 Apr; 15(4):387-93.
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  70. Abbara S, Migrino RQ, Sosnovik DE, Leichter JA, Brady TJ, Holmvang G. Value of fat suppression in the MRI evaluation of suspected arrhythmogenic right ventricular dysplasia. AJR Am J Roentgenol. 2004 Mar; 182(3):587-91.
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  71. Sosnovik DE, Januzzi JL, Church CC, Mertsch JA, Sears AL, Fetterman RC, Walovitch RC, Picard MH. Measurement of radial artery contrast intensity to assess cardiac microbubble behavior. J Am Soc Echocardiogr. 2003 Dec; 16(12):1267-73.
    View in: PubMed
  72. Sosnovik DE, Muller JE, Kathiresan S, Brady TJ. Non-invasive imaging of plaque vulnerability: an important tool for the assessment of agents to stabilise atherosclerotic plaques. Expert Opin Investig Drugs. 2002 May; 11(5):693-704.
    View in: PubMed
  73. Sosnovik DE, Baldwin SL, Lewis SH, Holland MR, Miller JG. Transmural variation of myocardial attenuation measured with a clinical imager. Ultrasound Med Biol. 2001 Dec; 27(12):1643-50.
    View in: PubMed
  74. Sosnovik DE, Baldwin SL, Holland MR, Miller JG. Transmural variation of myocardial attenuation and its potential effect on contrast-mediated estimates of regional myocardial perfusion. J Am Soc Echocardiogr. 2001 Aug; 14(8):782-8.
    View in: PubMed
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