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Thomas Steve Deisboeck, M.D.

TitleAssociate Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMGH - Radiology
Room 2301
149 13th Street
Charlestown MA 02129
Phone617/724-1845
Fax617/726-5079
Other Positions
TitleMember of the Affiliated Faculty of the Harvard-MIT Division of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Johnson D, McKeever S, Stamatakos G, Dionysiou D, Graf N, Sakkalis V, Marias K, Wang Z, Deisboeck TS. Dealing with diversity in computational cancer modeling. Cancer Inform. 2013; 12:115-24.
    View in: PubMed
  2. Wang Z, Sagotsky J, Taylor T, Shironoshita P, Deisboeck TS. Accelerating cancer systems biology research through Semantic Web technology. Wiley Interdiscip Rev Syst Biol Med. 2013 Mar; 5(2):135-51.
    View in: PubMed
  3. Sfakianakis S, Sakkalis V, Marias K, Stamatakos G, McKeever S, Deisboeck TS, Graf N. An architecture for integrating cancer model repositories. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012:6628-31.
    View in: PubMed
  4. Deisboeck TS, Wang Z, Macklin P, Cristini V. Multiscale cancer modeling. Annu Rev Biomed Eng. 2011 Aug 15; 13:127-55.
    View in: PubMed
  5. Wang Z, Bordas V, Deisboeck TS. Identification of Critical Molecular Components in a Multiscale Cancer Model Based on the Integration of Monte Carlo, Resampling, and ANOVA. Front Physiol. 2011; 2:35.
    View in: PubMed
  6. Wang Z, Bordas V, Sagotsky J, Deisboeck TS. Identifying therapeutic targets in a combined EGFR-TGFßR signalling cascade using a multiscale agent-based cancer model. Math Med Biol. 2012 Mar; 29(1):95-108.
    View in: PubMed
  7. Deisboeck TS, Sagotsky J. Professional networks in the life sciences: linking the linked. Cancer Inform. 2010; 9:189-95.
    View in: PubMed
  8. Chen LL, Ulmer S, Deisboeck TS. An agent-based model identifies MRI regions of probable tumor invasion in a patient with glioblastoma. Phys Med Biol. 2010 Jan 21; 55(2):329-38.
    View in: PubMed
  9. Castorina P, Carcò D, Guiot C, Deisboeck TS. Tumor growth instability and its implications for chemotherapy. Cancer Res. 2009 Nov 1; 69(21):8507-15.
    View in: PubMed
  10. Chen LL, Blumm N, Christakis NA, Barabási AL, Deisboeck TS. Cancer metastasis networks and the prediction of progression patterns. Br J Cancer. 2009 Sep 1; 101(5):749-58.
    View in: PubMed
  11. Wang Z, Birch CM, Sagotsky J, Deisboeck TS. Cross-scale, cross-pathway evaluation using an agent-based non-small cell lung cancer model. Bioinformatics. 2009 Sep 15; 25(18):2389-96.
    View in: PubMed
  12. Deisboeck TS. Personalizing medicine: a systems biology perspective. Mol Syst Biol. 2009; 5:249.
    View in: PubMed
  13. Yoon J, Deisboeck TS. Investigating differential dynamics of the MAPK signaling cascade using a multi-parametric global sensitivity analysis. PLoS One. 2009; 4(2):e4560.
    View in: PubMed
  14. Deisboeck TS, Couzin ID. Collective behavior in cancer cell populations. Bioessays. 2009 Feb; 31(2):190-7.
    View in: PubMed
  15. Deisboeck TS, Wang Z. A new concept for cancer therapy: out-competing the aggressor. Cancer Cell Int. 2008; 8:19.
    View in: PubMed
  16. Chen LL, Zhang L, Yoon J, Deisboeck TS. Cancer cell motility: optimizing spatial search strategies. Biosystems. 2009 Mar; 95(3):234-42.
    View in: PubMed
  17. Dattoli G, Guiot C, Delsanto PP, Ottaviani PL, Pagnutti S, Deisboeck TS. Cancer metabolism and the dynamics of metastasis. J Theor Biol. 2009 Feb 7; 256(3):305-10.
    View in: PubMed
  18. Deisboeck TS, Zhang L, Yoon J, Costa J. In silico cancer modeling: is it ready for prime time? Nat Clin Pract Oncol. 2009 Jan; 6(1):34-42.
    View in: PubMed
  19. Zhang L, Wang Z, Sagotsky JA, Deisboeck TS. Multiscale agent-based cancer modeling. J Math Biol. 2009 Apr; 58(4-5):545-59.
    View in: PubMed
  20. Sagotsky JA, Zhang L, Wang Z, Martin S, Deisboeck TS. Life Sciences and the web: a new era for collaboration. Mol Syst Biol. 2008; 4:201.
    View in: PubMed
  21. Solé RV, Rodríguez-Caso C, Deisboeck TS, Saldaña J. Cancer stem cells as the engine of unstable tumor progression. J Theor Biol. 2008 Aug 21; 253(4):629-37.
    View in: PubMed
  22. Deisboeck TS. Cancer: a profit-driven biosystem? Med Hypotheses. 2008 Aug; 71(2):186-9.
    View in: PubMed
  23. Deisboeck TS, Guiot C. Surgical impact on brain tumor invasion: a physical perspective. Ann Surg Innov Res. 2008; 2:1.
    View in: PubMed
  24. Wang Z, Birch CM, Deisboeck TS. Cross-scale sensitivity analysis of a non-small cell lung cancer model: linking molecular signaling properties to cellular behavior. Biosystems. 2008 Jun; 92(3):249-58.
    View in: PubMed
  25. Huang S, Vader D, Wang Z, Stemmer-Rachamimov A, Weitz DA, Dai G, Rosen BR, Deisboeck TS. Using magnetic resonance microscopy to study the growth dynamics of a glioma spheroid in collagen I: A case study. BMC Med Imaging. 2008; 8:3.
    View in: PubMed
  26. Wang Z, Zhang L, Sagotsky J, Deisboeck TS. Simulating non-small cell lung cancer with a multiscale agent-based model. Theor Biol Med Model. 2007; 4:50.
    View in: PubMed
  27. Guiot C, Pugno N, Delsanto PP, Deisboeck TS. Physical aspects of cancer invasion. Phys Biol. 2007 Dec; 4(4):P1-6.
    View in: PubMed
  28. Castorina P, Deisboeck TS, Gabriele P, Guiot C. Growth laws in cancer: implications for radiotherapy. Radiat Res. 2007 Sep; 168(3):349-56.
    View in: PubMed
  29. Deisboeck TS, Zhang L, Martin S. Advancing cancer systems biology: introducing the Center for the Development of a Virtual Tumor, CViT. Cancer Inform. 2007; 5:1-8.
    View in: PubMed
  30. Guiot C, Delsanto PP, Deisboeck TS. Morphological instability and cancer invasion: a 'splashing water drop' analogy. Theor Biol Med Model. 2007; 4:4.
    View in: PubMed
  31. Deisboeck TS, Wang Z. Cancer dissemination: a consequence of limited carrying capacity? Med Hypotheses. 2007; 69(1):173-7.
    View in: PubMed
  32. Zhang L, Athale CA, Deisboeck TS. Development of a three-dimensional multiscale agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer. J Theor Biol. 2007 Jan 7; 244(1):96-107.
    View in: PubMed
  33. Deisboeck TS, Guiot C, Delsanto PP, Pugno N. Does cancer growth depend on surface extension? Med Hypotheses. 2006; 67(6):1338-41.
    View in: PubMed
  34. Guiot C, Delsanto PP, Carpinteri A, Pugno N, Mansury Y, Deisboeck TS. The dynamic evolution of the power exponent in a universal growth model of tumors. J Theor Biol. 2006 Jun 7; 240(3):459-63.
    View in: PubMed
  35. Castro M, Molina-París C, Deisboeck TS. Tumor growth instability and the onset of invasion. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Oct; 72(4 Pt 1):041907.
    View in: PubMed
  36. Athale CA, Deisboeck TS. The effects of EGF-receptor density on multiscale tumor growth patterns. J Theor Biol. 2006 Feb 21; 238(4):771-9.
    View in: PubMed
  37. Mansury Y, Diggory M, Deisboeck TS. Evolutionary game theory in an agent-based brain tumor model: exploring the 'Genotype-Phenotype' link. J Theor Biol. 2006 Jan 7; 238(1):146-56.
    View in: PubMed
  38. Kaufman LJ, Brangwynne CP, Kasza KE, Filippidi E, Gordon VD, Deisboeck TS, Weitz DA. Glioma expansion in collagen I matrices: analyzing collagen concentration-dependent growth and motility patterns. Biophys J. 2005 Jul; 89(1):635-50.
    View in: PubMed
  39. Deisboeck TS, Mansury Y, Guiot C, Degiorgis PG, Delsanto PP. Insights from a novel tumor model: Indications for a quantitative link between tumor growth and invasion. Med Hypotheses. 2005; 65(4):785-90.
    View in: PubMed
  40. Deisboeck TS, Demuth T, Mansury Y. Correlating velocity patterns with spatial dynamics in glioma cell migration. Acta Biotheor. 2005; 53(3):181-90.
    View in: PubMed
  41. Athale C, Mansury Y, Deisboeck TS. Simulating the impact of a molecular 'decision-process' on cellular phenotype and multicellular patterns in brain tumors. J Theor Biol. 2005 Apr 21; 233(4):469-81.
    View in: PubMed
  42. Solé RV, Deisboeck TS. An error catastrophe in cancer? J Theor Biol. 2004 May 7; 228(1):47-54.
    View in: PubMed
  43. Zhang S, Bastin ME, Laidlaw DH, Sinha S, Armitage PA, Deisboeck TS. Visualization and analysis of white matter structural asymmetry in diffusion tensor MRI data. Magn Reson Med. 2004 Jan; 51(1):140-7.
    View in: PubMed
  44. Guiot C, Degiorgis PG, Delsanto PP, Gabriele P, Deisboeck TS. Does tumor growth follow a "universal law"? J Theor Biol. 2003 Nov 21; 225(2):147-51.
    View in: PubMed
  45. Mansury Y, Deisboeck TS. The impact of "search precision" in an agent-based tumor model. J Theor Biol. 2003 Oct 7; 224(3):325-37.
    View in: PubMed
  46. Gordon VD, Valentine MT, Gardel ML, Andor-Ardó D, Dennison S, Bogdanov AA, Weitz DA, Deisboeck TS. Measuring the mechanical stress induced by an expanding multicellular tumor system: a case study. Exp Cell Res. 2003 Sep 10; 289(1):58-66.
    View in: PubMed
  47. Deisboeck TS, Wakimoto H, Nestler U, Louis DN, Sehgal PK, Simon M, Chiocca EA, Hochberg FH. Development of a novel non-human primate model for preclinical gene vector safety studies. Determining the effects of intracerebral HSV-1 inoculation in the common marmoset: a comparative study. Gene Ther. 2003 Aug; 10(15):1225-33.
    View in: PubMed
  48. Mansury Y, Kimura M, Lobo J, Deisboeck TS. Emerging patterns in tumor systems: simulating the dynamics of multicellular clusters with an agent-based spatial agglomeration model. J Theor Biol. 2002 Dec 7; 219(3):343-70.
    View in: PubMed
  49. Sander LM, Deisboeck TS. Growth patterns of microscopic brain tumors. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Nov; 66(5 Pt 1):051901.
    View in: PubMed
  50. Mojsilovic A, Rogowitz B, Gomes J, Deisboeck TS. Analysis and 3D reconstruction of heterogeneity in malignant brain tumors: an interdisciplinary case study using a novel computational visualization approach. Anal Quant Cytol Histol. 2002 Jun; 24(3):125-33.
    View in: PubMed
  51. Deisboeck TS, Berens ME, Kansal AR, Torquato S, Stemmer-Rachamimov AO, Chiocca EA. Pattern of self-organization in tumour systems: complex growth dynamics in a novel brain tumour spheroid model. Cell Prolif. 2001 Apr; 34(2):115-34.
    View in: PubMed
  52. Kansal AR, Torquato S, Chiocca EA, Deisboeck TS. Emergence of a subpopulation in a computational model of tumor growth. J Theor Biol. 2000 Dec 7; 207(3):431-41.
    View in: PubMed
  53. Harsh GR, Deisboeck TS, Louis DN, Hilton J, Colvin M, Silver JS, Qureshi NH, Kracher J, Finkelstein D, Chiocca EA, Hochberg FH. Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: a gene-marking and neuropathological study. J Neurosurg. 2000 May; 92(5):804-11.
    View in: PubMed
  54. Kansal AR, Torquato S, Harsh GR IV, Chiocca EA, Deisboeck TS. Simulated brain tumor growth dynamics using a three-dimensional cellular automaton. J Theor Biol. 2000 Apr 21; 203(4):367-82.
    View in: PubMed
  55. Kansal AR, Torquato S, Harsh IV GR, Chiocca EA, Deisboeck TS. Cellular automaton of idealized brain tumor growth dynamics. Biosystems. 2000 Feb; 55(1-3):119-27.
    View in: PubMed
  56. Ikeda K, Ichikawa T, Wakimoto H, Silver JS, Deisboeck TS, Finkelstein D, Harsh GR, Louis DN, Bartus RT, Hochberg FH, Chiocca EA. Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nat Med. 1999 Aug; 5(8):881-7.
    View in: PubMed
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