Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Arno W. Tilles, M.D.

TitleInstructor in Surgery
InstitutionMassachusetts General Hospital
DepartmentSurgery
AddressMassachusetts General Hospital
Center for Engineering in Med.
51 Blossom St
Boston MA 02114
Phone617/302-7661
Fax617/371-4950

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Milwid JM, Ichimura T, Li M, Jiao Y, Lee J, Yarmush JS, Parekkadan B, Tilles AW, Bonventre JV, Yarmush ML. Secreted factors from bone marrow stromal cells upregulate IL-10 and reverse acute kidney injury. Stem Cells Int. 2012; 2012:392050.
    View in: PubMed
  2. Ono S, Obara H, Takayanagi A, Tanabe M, Kawachi S, Itano O, Shinoda M, Kitago M, Hibi T, Chiba T, Du W, Matsumoto K, Tilles AW, Yarmush ML, Aiso S, Shimizu N, Sakamoto M, Kitagawa Y. Suppressive effects of interleukin-18 on liver function in rat liver allografts. J Surg Res. 2012 Jul; 176(1):293-300.
    View in: PubMed
  3. Li M, Tilles AW, Milwid JM, Hammad M, Lee J, Yarmush ML, Parekkadan B. Phenotypic and functional characterization of human bone marrow stromal cells in hollow-fibre bioreactors. J Tissue Eng Regen Med. 2012 May; 6(5):369-77.
    View in: PubMed
  4. Patel SJ, Jindal R, King KR, Tilles AW, Yarmush ML. The inflammatory response to double stranded DNA in endothelial cells is mediated by NF?B and TNFa. PLoS One. 2011; 6(5):e19910.
    View in: PubMed
  5. Yagi H, Soto-Gutierrez A, Navarro-Alvarez N, Nahmias Y, Goldwasser Y, Kitagawa Y, Tilles AW, Tompkins RG, Parekkadan B, Yarmush ML. Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1. Mol Ther. 2010 Oct; 18(10):1857-64.
    View in: PubMed
  6. Yagi H, Soto-Gutierrez A, Kitagawa Y, Tilles AW, Tompkins RG, Yarmush ML. Bone marrow mesenchymal stromal cells attenuate organ injury induced by LPS and burn. Cell Transplant. 2010; 19(6):823-30.
    View in: PubMed
  7. Uygun BE, Soto-Gutierrez A, Yagi H, Izamis ML, Guzzardi MA, Shulman C, Milwid J, Kobayashi N, Tilles A, Berthiaume F, Hertl M, Nahmias Y, Yarmush ML, Uygun K. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med. 2010 Jul; 16(7):814-20.
    View in: PubMed
  8. Nagrath D, Avila-Elchiver M, Berthiaume F, Tilles AW, Messac A, Yarmush ML. Soft constraints-based multiobjective framework for flux balance analysis. Metab Eng. 2010 Sep; 12(5):429-45.
    View in: PubMed
  9. Cho CH, Park J, Tilles AW, Berthiaume F, Toner M, Yarmush ML. Layered patterning of hepatocytes in co-culture systems using microfabricated stencils. Biotechniques. 2010 Jan; 48(1):47-52.
    View in: PubMed
  10. Yagi H, Parekkadan B, Suganuma K, Soto-Gutierrez A, Tompkins RG, Tilles AW, Yarmush ML. Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure. Tissue Eng Part A. 2009 Nov; 15(11):3377-88.
    View in: PubMed
  11. Jindal R, Nahmias Y, Tilles AW, Berthiaume F, Yarmush ML. Amino acid-mediated heterotypic interaction governs performance of a hepatic tissue model. FASEB J. 2009 Jul; 23(7):2288-98.
    View in: PubMed
  12. Cho CH, Berthiaume F, Tilles AW, Yarmush ML. A new technique for primary hepatocyte expansion in vitro. Biotechnol Bioeng. 2008 Oct 1; 101(2):345-56.
    View in: PubMed
  13. van Poll D, Parekkadan B, Cho CH, Berthiaume F, Nahmias Y, Tilles AW, Yarmush ML. Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo. Hepatology. 2008 May; 47(5):1634-43.
    View in: PubMed
  14. Parekkadan B, Tilles AW, Yarmush ML. Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independently of regulatory T cells. Stem Cells. 2008 Jul; 26(7):1913-9.
    View in: PubMed
  15. Park J, Li Y, Berthiaume F, Toner M, Yarmush ML, Tilles AW. Radial flow hepatocyte bioreactor using stacked microfabricated grooved substrates. Biotechnol Bioeng. 2008 Feb 1; 99(2):455-67.
    View in: PubMed
  16. Parashurama N, Nahmias Y, Cho CH, van Poll D, Tilles AW, Berthiaume F, Yarmush ML. Activin alters the kinetics of endoderm induction in embryonic stem cells cultured on collagen gels. Stem Cells. 2008 Feb; 26(2):474-84.
    View in: PubMed
  17. Cho CH, Parashurama N, Park EY, Suganuma K, Nahmias Y, Park J, Tilles AW, Berthiaume F, Yarmush ML. Homogeneous differentiation of hepatocyte-like cells from embryonic stem cells: applications for the treatment of liver failure. FASEB J. 2008 Mar; 22(3):898-909.
    View in: PubMed
  18. Parekkadan B, van Poll D, Suganuma K, Carter EA, Berthiaume F, Tilles AW, Yarmush ML. Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure. PLoS One. 2007; 2(9):e941.
    View in: PubMed
  19. Park J, Cho CH, Parashurama N, Li Y, Berthiaume F, Toner M, Tilles AW, Yarmush ML. Microfabrication-based modulation of embryonic stem cell differentiation. Lab Chip. 2007 Aug; 7(8):1018-28.
    View in: PubMed
  20. Parekkadan B, van Poll D, Megeed Z, Kobayashi N, Tilles AW, Berthiaume F, Yarmush ML. Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells. Biochem Biophys Res Commun. 2007 Nov 16; 363(2):247-52.
    View in: PubMed
  21. Cho CH, Park J, Nagrath D, Tilles AW, Berthiaume F, Toner M, Yarmush ML. Oxygen uptake rates and liver-specific functions of hepatocyte and 3T3 fibroblast co-cultures. Biotechnol Bioeng. 2007 May 1; 97(1):188-99.
    View in: PubMed
  22. Nagrath D, Avila-Elchiver M, Berthiaume F, Tilles AW, Messac A, Yarmush ML. Integrated energy and flux balance based multiobjective framework for large-scale metabolic networks. Ann Biomed Eng. 2007 Jun; 35(6):863-85.
    View in: PubMed
  23. Shinoda M, Tilles AW, Kobayashi N, Wakabayashi G, Takayanagi A, Totsugawa T, Harada H, Obara H, Suganuma K, Berthiaume F, Shimazu M, Shimizu N, Tanaka N, Kitajima M, Tompkins RG, Toner M, Yarmush ML. A bioartificial liver device secreting interleukin-1 receptor antagonist for the treatment of hepatic failure in rats. J Surg Res. 2007 Jan; 137(1):130-40.
    View in: PubMed
  24. van Poll D, Sokmensuer C, Ahmad N, Tilles AW, Berthiaume F, Toner M, Yarmush ML. Elevated hepatocyte-specific functions in fetal rat hepatocytes co-cultured with adult rat hepatocytes. Tissue Eng. 2006 Oct; 12(10):2965-73.
    View in: PubMed
  25. Rajagopalan P, Shen CJ, Berthiaume F, Tilles AW, Toner M, Yarmush ML. Polyelectrolyte nano-scaffolds for the design of layered cellular architectures. Tissue Eng. 2006 Jun; 12(6):1553-63.
    View in: PubMed
  26. Shinoda M, Tilles AW, Wakabayashi G, Takayanagi A, Harada H, Obara H, Suganuma K, Berthiaume F, Shimazu M, Shimizu N, Kitajima M, Tompkins RG, Toner M, Yarmush ML. Treatment of fulminant hepatic failure in rats using a bioartificial liver device containing porcine hepatocytes producing interleukin-1 receptor antagonist. Tissue Eng. 2006 May; 12(5):1313-23.
    View in: PubMed
  27. Rajagopalan P, Berthiaume F, Tilles AW, Toner M, Yarmush ML. Selective enhancement of cytochrome p-450 activity in rat hepatocytes by in vitro heat shock. Tissue Eng. 2005 Sep-Oct; 11(9-10):1527-34.
    View in: PubMed
  28. Park J, Berthiaume F, Toner M, Yarmush ML, Tilles AW. Microfabricated grooved substrates as platforms for bioartificial liver reactors. Biotechnol Bioeng. 2005 Jun 5; 90(5):632-44.
    View in: PubMed
  29. Chan C, Berthiaume F, Nath BD, Tilles AW, Toner M, Yarmush ML. Hepatic tissue engineering for adjunct and temporary liver support: critical technologies. Liver Transpl. 2004 Nov; 10(11):1331-42.
    View in: PubMed
  30. Revzin A, Rajagopalan P, Tilles AW, Berthiaume F, Yarmush ML, Toner M. Designing a hepatocellular microenvironment with protein microarraying and poly(ethylene glycol) photolithography. Langmuir. 2004 Apr 13; 20(8):2999-3005.
    View in: PubMed
  31. Shito M, Tilles AW, Tompkins RG, Yarmush ML, Toner M. Efficacy of an extracorporeal flat-plate bioartificial liver in treating fulminant hepatic failure. J Surg Res. 2003 May 1; 111(1):53-62.
    View in: PubMed
  32. Tilles AW, Berthiaume F, Yarmush ML, Tompkins RG, Toner M. Bioengineering of liver assist devices. J Hepatobiliary Pancreat Surg. 2002; 9(6):686-96.
    View in: PubMed
  33. Tilles AW, Berthiaume F, Yarmush ML, Toner M. Critical issues in bioartificial liver development. Technol Health Care. 2002; 10(3-4):177-86.
    View in: PubMed
  34. Roy P, Baskaran H, Tilles AW, Yarmush ML, Toner M. Analysis of oxygen transport to hepatocytes in a flat-plate microchannel bioreactor. Ann Biomed Eng. 2001 Nov; 29(11):947-55.
    View in: PubMed
  35. Shito M, Kim NH, Baskaran H, Tilles AW, Tompkins RG, Yarmush ML, Toner M. In vitro and in vivo evaluation of albumin synthesis rate of porcine hepatocytes in a flat-plate bioreactor. Artif Organs. 2001 Jul; 25(7):571-8.
    View in: PubMed
  36. Tilles AW, Baskaran H, Roy P, Yarmush ML, Toner M. Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor. Biotechnol Bioeng. 2001 Jun 5; 73(5):379-89.
    View in: PubMed
  37. Roy P, Washizu J, Tilles AW, Yarmush ML, Toner M. Effect of flow on the detoxification function of rat hepatocytes in a bioartificial liver reactor. Cell Transplant. 2001; 10(7):609-14.
    View in: PubMed
  38. Tilles AW, Classen JM, Toner M, Van De Water L. Simple devices to facilitate the analysis of collagen contraction by cells. Biotechniques. 2000 Sep; 29(3):412-4, 416, 418.
    View in: PubMed
  39. Eckstein EC, Tilles AW, Millero FJ. Conditions for the occurrence of large near-wall excesses of small particles during blood flow. Microvasc Res. 1988 Jul; 36(1):31-9.
    View in: PubMed
  40. Tilles AW, Eckstein EC. The near-wall excess of platelet-sized particles in blood flow: its dependence on hematocrit and wall shear rate. Microvasc Res. 1987 Mar; 33(2):211-23.
    View in: PubMed
  41. Eckstein EC, Bilsker DL, Waters CM, Kippenhan JS, Tilles AW. Transport of platelets in flowing blood. Ann N Y Acad Sci. 1987; 516:442-52.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Tilles's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
See all (203) concept(s)
_
Co-Authors
See all (16) people
_
Similar People
See all (60) people
_
Same Department
Search Department
Physical Neighbors
_