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Angelika Amon, PH.D.

TitleLecturer on Cell Biology
InstitutionHarvard Medical School
DepartmentCell Biology
AddressMass Institute of Technology
Center for Cancer Research
77 Massachusetts Ave
Cambridge MA 02139
Phone617/258-8964

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Tang YC, Amon A. Gene copy-number alterations: a cost-benefit analysis. Cell. 2013 Jan 31; 152(3):394-405.
    View in: PubMed
  2. Miller MP, Unal E, Brar GA, Amon A. Meiosis I chromosome segregation is established through regulation of microtubule-kinetochore interactions. elife. 2012; 1:e00117.
    View in: PubMed
  3. Oromendia AB, Dodgson SE, Amon A. Aneuploidy causes proteotoxic stress in yeast. Genes Dev. 2012 Dec 15; 26(24):2696-708.
    View in: PubMed
  4. van Werven FJ, Neuert G, Hendrick N, Lardenois A, Buratowski S, van Oudenaarden A, Primig M, Amon A. Transcription of two long noncoding RNAs mediates mating-type control of gametogenesis in budding yeast. Cell. 2012 Sep 14; 150(6):1170-81.
    View in: PubMed
  5. Sheltzer JM, Torres EM, Dunham MJ, Amon A. Transcriptional consequences of aneuploidy. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12644-9.
    View in: PubMed
  6. Siegel JJ, Amon A. New insights into the troubles of aneuploidy. Annu Rev Cell Dev Biol. 2012 Nov 10; 28:189-214.
    View in: PubMed
  7. Attner MA, Amon A. Control of the mitotic exit network during meiosis. Mol Biol Cell. 2012 Aug; 23(16):3122-32.
    View in: PubMed
  8. Pfau SJ, Amon A. Chromosomal instability and aneuploidy in cancer: from yeast to man. EMBO Rep. 2012 Jun; 13(6):515-27.
    View in: PubMed
  9. van Werven FJ, Amon A. Regulation of entry into gametogenesis. Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27; 366(1584):3521-31.
    View in: PubMed
  10. Rock JM, Amon A. Cdc15 integrates Tem1 GTPase-mediated spatial signals with Polo kinase-mediated temporal cues to activate mitotic exit. Genes Dev. 2011 Sep 15; 25(18):1943-54.
    View in: PubMed
  11. Sheltzer JM, Amon A. The aneuploidy paradox: costs and benefits of an incorrect karyotype. Trends Genet. 2011 Nov; 27(11):446-53.
    View in: PubMed
  12. Sheltzer JM, Blank HM, Pfau SJ, Tange Y, George BM, Humpton TJ, Brito IL, Hiraoka Y, Niwa O, Amon A. Aneuploidy drives genomic instability in yeast. Science. 2011 Aug 19; 333(6045):1026-30.
    View in: PubMed
  13. Falk JE, Chan LY, Amon A. Lte1 promotes mitotic exit by controlling the localization of the spindle position checkpoint kinase Kin4. Proc Natl Acad Sci U S A. 2011 Aug 2; 108(31):12584-90.
    View in: PubMed
  14. Unal E, Kinde B, Amon A. Gametogenesis eliminates age-induced cellular damage and resets life span in yeast. Science. 2011 Jun 24; 332(6037):1554-7.
    View in: PubMed
  15. Amon A. Angelika Amon: conquering the divide. Interview by Ben Short. J Cell Biol. 2011 Apr 18; 193(2):254-5.
    View in: PubMed
  16. Tang YC, Williams BR, Siegel JJ, Amon A. Identification of aneuploidy-selective antiproliferation compounds. Cell. 2011 Feb 18; 144(4):499-512.
    View in: PubMed
  17. Torres EM, Dephoure N, Panneerselvam A, Tucker CM, Whittaker CA, Gygi SP, Dunham MJ, Amon A. Identification of aneuploidy-tolerating mutations. Cell. 2010 Oct 1; 143(1):71-83.
    View in: PubMed
  18. Brito IL, Monje-Casas F, Amon A. The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for accurate chromosome segregation. Cell Cycle. 2010 Sep 1; 9(17):3611-8.
    View in: PubMed
  19. Corbett KD, Yip CK, Ee LS, Walz T, Amon A, Harrison SC. The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments. Cell. 2010 Aug 20; 142(4):556-67.
    View in: PubMed
  20. Chan LY, Amon A. Spindle position is coordinated with cell-cycle progression through establishment of mitotic exit-activating and -inhibitory zones. Mol Cell. 2010 Aug 13; 39(3):444-54.
    View in: PubMed
  21. Goranov AI, Amon A. Growth and division--not a one-way road. Curr Opin Cell Biol. 2010 Dec; 22(6):795-800.
    View in: PubMed
  22. Brito IL, Yu HG, Amon A. Condensins promote coorientation of sister chromatids during meiosis I in budding yeast. Genetics. 2010 May; 185(1):55-64.
    View in: PubMed
  23. Bryan AK, Goranov A, Amon A, Manalis SR. Measurement of mass, density, and volume during the cell cycle of yeast. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):999-1004.
    View in: PubMed
  24. Rock JM, Amon A. The FEAR network. Curr Biol. 2009 Dec 15; 19(23):R1063-8.
    View in: PubMed
  25. Amon A, Tyers M. Life and death decisions. Curr Opin Cell Biol. 2009 Dec; 21(6):767-70.
    View in: PubMed
  26. Chan LY, Amon A. The protein phosphatase 2A functions in the spindle position checkpoint by regulating the checkpoint kinase Kin4. Genes Dev. 2009 Jul 15; 23(14):1639-49.
    View in: PubMed
  27. Williams BR, Amon A. Aneuploidy: cancer's fatal flaw? Cancer Res. 2009 Jul 1; 69(13):5289-91.
    View in: PubMed
  28. Goranov AI, Cook M, Ricicova M, Ben-Ari G, Gonzalez C, Hansen C, Tyers M, Amon A. The rate of cell growth is governed by cell cycle stage. Genes Dev. 2009 Jun 15; 23(12):1408-22.
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  29. Boselli M, Rock J, Unal E, Levine SS, Amon A. Effects of age on meiosis in budding yeast. Dev Cell. 2009 Jun; 16(6):844-55.
    View in: PubMed
  30. Tomson BN, Rahal R, Reiser V, Monje-Casas F, Mekhail K, Moazed D, Amon A. Regulation of Spo12 phosphorylation and its essential role in the FEAR network. Curr Biol. 2009 Mar 24; 19(6):449-60.
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  31. Monje-Casas F, Amon A. Cell polarity determinants establish asymmetry in MEN signaling. Dev Cell. 2009 Jan; 16(1):132-45.
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  32. Brar GA, Hochwagen A, Ee LS, Amon A. The multiple roles of cohesin in meiotic chromosome morphogenesis and pairing. Mol Biol Cell. 2009 Feb; 20(3):1030-47.
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  33. Brar GA, Amon A. Emerging roles for centromeres in meiosis I chromosome segregation. Nat Rev Genet. 2008 Dec; 9(12):899-910.
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  34. Amon A. A decade of Cdc14--a personal perspective. Delivered on 9 July 2007 at the 32nd FEBS Congress in Vienna, Austria. FEBS J. 2008 Dec; 275(23):5774-84.
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  35. Williams BR, Prabhu VR, Hunter KE, Glazier CM, Whittaker CA, Housman DE, Amon A. Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science. 2008 Oct 31; 322(5902):703-9.
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  36. Rahal R, Amon A. The Polo-like kinase Cdc5 interacts with FEAR network components and Cdc14. Cell Cycle. 2008 Oct; 7(20):3262-72.
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  37. Jambhekar A, Amon A. Control of meiosis by respiration. Curr Biol. 2008 Jul 8; 18(13):969-75.
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  38. Rahal R, Amon A. Mitotic CDKs control the metaphase-anaphase transition and trigger spindle elongation. Genes Dev. 2008 Jun 1; 22(11):1534-48.
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  39. Torres EM, Williams BR, Amon A. Aneuploidy: cells losing their balance. Genetics. 2008 Jun; 179(2):737-46.
    View in: PubMed
  40. Carlile TM, Amon A. Meiosis I is established through division-specific translational control of a cyclin. Cell. 2008 Apr 18; 133(2):280-91.
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  41. Visintin C, Tomson BN, Rahal R, Paulson J, Cohen M, Taunton J, Amon A, Visintin R. APC/C-Cdh1-mediated degradation of the Polo kinase Cdc5 promotes the return of Cdc14 into the nucleolus. Genes Dev. 2008 Jan 1; 22(1):79-90.
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  42. Kiburz BM, Amon A, Marston AL. Shugoshin promotes sister kinetochore biorientation in Saccharomyces cerevisiae. Mol Biol Cell. 2008 Mar; 19(3):1199-209.
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  43. Torres EM, Sokolsky T, Tucker CM, Chan LY, Boselli M, Dunham MJ, Amon A. Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science. 2007 Aug 17; 317(5840):916-24.
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  44. Monje-Casas F, Prabhu VR, Lee BH, Boselli M, Amon A. Kinetochore orientation during meiosis is controlled by Aurora B and the monopolin complex. Cell. 2007 Feb 9; 128(3):477-90.
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  45. Huang J, Brito IL, Villén J, Gygi SP, Amon A, Moazed D. Inhibition of homologous recombination by a cohesin-associated clamp complex recruited to the rDNA recombination enhancer. Genes Dev. 2006 Oct 15; 20(20):2887-901.
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  46. Tomson BN, D'Amours D, Adamson BS, Aragon L, Amon A. Ribosomal DNA transcription-dependent processes interfere with chromosome segregation. Mol Cell Biol. 2006 Aug; 26(16):6239-47.
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  47. Reiser V, D'Aquino KE, Ee LS, Amon A. The stress-activated mitogen-activated protein kinase signaling cascade promotes exit from mitosis. Mol Biol Cell. 2006 Jul; 17(7):3136-46.
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  48. Brar GA, Kiburz BM, Zhang Y, Kim JE, White F, Amon A. Rec8 phosphorylation and recombination promote the step-wise loss of cohesins in meiosis. Nature. 2006 May 25; 441(7092):532-6.
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  49. Hochwagen A, Amon A. Checking your breaks: surveillance mechanisms of meiotic recombination. Curr Biol. 2006 Mar 21; 16(6):R217-28.
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  50. Kiburz BM, Reynolds DB, Megee PC, Marston AL, Lee BH, Lee TI, Levine SS, Young RA, Amon A. The core centromere and Sgo1 establish a 50-kb cohesin-protected domain around centromeres during meiosis I. Genes Dev. 2005 Dec 15; 19(24):3017-30.
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  51. Hochwagen A, Tham WH, Brar GA, Amon A. The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity. Cell. 2005 Sep 23; 122(6):861-73.
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  52. Seshan A, Amon A. Ras and the Rho effector Cla4 collaborate to target and anchor Lte1 at the bud cortex. Cell Cycle. 2005 Jul; 4(7):940-6.
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  53. D'Aquino KE, Monje-Casas F, Paulson J, Reiser V, Charles GM, Lai L, Shokat KM, Amon A. The protein kinase Kin4 inhibits exit from mitosis in response to spindle position defects. Mol Cell. 2005 Jul 22; 19(2):223-34.
    View in: PubMed
  54. Hochwagen A, Wrobel G, Cartron M, Demougin P, Niederhauser-Wiederkehr C, Boselli MG, Primig M, Amon A. Novel response to microtubule perturbation in meiosis. Mol Cell Biol. 2005 Jun; 25(11):4767-81.
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  55. Lee BH, Kiburz BM, Amon A. Spo13 maintains centromeric cohesion and kinetochore coorientation during meiosis I. Curr Biol. 2004 Dec 29; 14(24):2168-82.
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  56. Marston AL, Amon A. Meiosis: cell-cycle controls shuffle and deal. Nat Rev Mol Cell Biol. 2004 Dec; 5(12):983-97.
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  57. D'Amours D, Amon A. At the interface between signaling and executing anaphase--Cdc14 and the FEAR network. Genes Dev. 2004 Nov 1; 18(21):2581-95.
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  58. D'Amours D, Stegmeier F, Amon A. Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA. Cell. 2004 May 14; 117(4):455-69.
    View in: PubMed
  59. Stegmeier F, Huang J, Rahal R, Zmolik J, Moazed D, Amon A. The replication fork block protein Fob1 functions as a negative regulator of the FEAR network. Curr Biol. 2004 Mar 23; 14(6):467-80.
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  60. Seshan A, Amon A. Linked for life: temporal and spatial coordination of late mitotic events. Curr Opin Cell Biol. 2004 Feb; 16(1):41-8.
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  61. Marston AL, Tham WH, Shah H, Amon A. A genome-wide screen identifies genes required for centromeric cohesion. Science. 2004 Feb 27; 303(5662):1367-70.
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  62. Stegmeier F, Amon A. Closing mitosis: the functions of the Cdc14 phosphatase and its regulation. Annu Rev Genet. 2004; 38:203-32.
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  63. Lee BH, Amon A. Polo kinase--meiotic cell cycle coordinator. Cell Cycle. 2003 Sep-Oct; 2(5):400-2.
    View in: PubMed
  64. Visintin R, Stegmeier F, Amon A. The role of the polo kinase Cdc5 in controlling Cdc14 localization. Mol Biol Cell. 2003 Nov; 14(11):4486-98.
    View in: PubMed
  65. Bardin AJ, Boselli MG, Amon A. Mitotic exit regulation through distinct domains within the protein kinase Cdc15. Mol Cell Biol. 2003 Jul; 23(14):5018-30.
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  66. Marston AL, Lee BH, Amon A. The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation. Dev Cell. 2003 May; 4(5):711-26.
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  67. Lee BH, Amon A. Role of Polo-like kinase CDC5 in programming meiosis I chromosome segregation. Science. 2003 Apr 18; 300(5618):482-6.
    View in: PubMed
  68. Seshan A, Bardin AJ, Amon A. Control of Lte1 localization by cell polarity determinants and Cdc14. Curr Biol. 2002 Dec 23; 12(24):2098-110.
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  69. Lee BH, Amon A, Prinz S. Spo13 regulates cohesin cleavage. Genes Dev. 2002 Jul 1; 16(13):1672-81.
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  70. Elledge SJ, Amon A. The BRCA1 suppressor hypothesis: an explanation for the tissue-specific tumor development in BRCA1 patients. Cancer Cell. 2002 Mar; 1(2):129-32.
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  71. Stegmeier F, Visintin R, Amon A. Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase. Cell. 2002 Jan 25; 108(2):207-20.
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  72. Amon A. Synchronization procedures. Methods Enzymol. 2002; 351:457-67.
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  73. Amon A. Together until separin do us part. Nat Cell Biol. 2001 Jan; 3(1):E12-4.
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  74. Amon A. The spindle checkpoint. Curr Opin Genet Dev. 1999 Feb; 9(1):69-75.
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  75. Visintin R, Craig K, Hwang ES, Prinz S, Tyers M, Amon A. The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation. Mol Cell. 1998 Dec; 2(6):709-18.
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  76. Prinz S, Hwang ES, Visintin R, Amon A. The regulation of Cdc20 proteolysis reveals a role for APC components Cdc23 and Cdc27 during S phase and early mitosis. Curr Biol. 1998 Jun 18; 8(13):750-60.
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  77. Amon A. Controlling cell cycle and cell fate: common strategies in prokaryotes and eukaryotes. Proc Natl Acad Sci U S A. 1998 Jan 6; 95(1):85-6.
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  78. Visintin R, Prinz S, Amon A. CDC20 and CDH1: a family of substrate-specific activators of APC-dependent proteolysis. Science. 1997 Oct 17; 278(5337):460-3.
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  79. Amon A. Regulation of B-type cyclin proteolysis by Cdc28-associated kinases in budding yeast. EMBO J. 1997 May 15; 16(10):2693-702.
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  80. Amon A. Mother and daughter are doing fine: asymmetric cell division in yeast. Cell. 1996 Mar 8; 84(5):651-4.
    View in: PubMed
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