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Barry Eisenstein, M.D.

TitleClinical Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med. Center
330 Brookline Ave
Boston MA 02215
Phone617/575-3000

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rex JH, Eisenstein BI, Alder J, Goldberger M, Meyer R, Dane A, Friedland I, Knirsch C, Sanhai WR, Tomayko J, Lancaster C, Jackson J. A comprehensive regulatory framework to address the unmet need for new antibacterial treatments. Lancet Infect Dis. 2013 Mar; 13(3):269-75.
    View in: PubMed
  2. Spellberg B, Blaser M, Guidos RJ, Boucher HW, Bradley JS, Eisenstein BI, Gerding D, Lynfield R, Reller LB, Rex J, Schwartz D, Septimus E, Tenover FC, Gilbert DN. Combating antimicrobial resistance: policy recommendations to save lives. Clin Infect Dis. 2011 May; 52 Suppl 5:S397-428.
    View in: PubMed
  3. Donovan BJ, Mohr JF, Knapp AG, Eisenstein BI. Decreasing the probability of creatine phosphokinase elevations: clinical considerations for daptomycin dosing in obese patients. Clin Infect Dis. 2010 Oct 15; 51(8):989; author reply 989-90.
    View in: PubMed
  4. Eisenstein BI, Oleson FB, Baltz RH. Daptomycin: from the mountain to the clinic, with essential help from Francis Tally, MD. Clin Infect Dis. 2010 Jan 1; 50 Suppl 1:S10-5.
    View in: PubMed
  5. Pertel PE, Eisenstein BI, Link AS, Donfrid B, Biermann EJ, Bernardo P, Martone WJ. The efficacy and safety of daptomycin vs. vancomycin for the treatment of cellulitis and erysipelas. Int J Clin Pract. 2009 Mar; 63(3):368-75.
    View in: PubMed
  6. Rehm SJ, Boucher H, Levine D, Campion M, Eisenstein BI, Vigliani GA, Corey GR, Abrutyn E. Daptomycin versus vancomycin plus gentamicin for treatment of bacteraemia and endocarditis due to Staphylococcus aureus: subset analysis of patients infected with methicillin-resistant isolates. J Antimicrob Chemother. 2008 Dec; 62(6):1413-21.
    View in: PubMed
  7. Eisenstein BI. Treatment challenges in the management of complicated skin and soft-tissue infections. Clin Microbiol Infect. 2008 Mar; 14 Suppl 2:17-25.
    View in: PubMed
  8. Eisenstein BI. Treatment of staphylococcal infections with cyclic lipopeptides. Clin Microbiol Infect. 2008 Mar; 14 Suppl 2:10-6.
    View in: PubMed
  9. Eisenstein BI. Use of daptomycin for treatment of Staphylococcus aureus infections. Expert Opin Drug Discov. 2007 Nov; 2(11):1523-36.
    View in: PubMed
  10. Alder J, Eisenstein BI. The clinical relevance and correct designation of isolates nonsusceptible to daptomycin. Clin Infect Dis. 2005 Aug 1; 41(3):411-2; author reply 412-3.
    View in: PubMed
  11. Anton PM, O'Brien M, Kokkotou E, Eisenstein B, Michaelis A, Rothstein D, Paraschos S, Kelly CP, Pothoulakis C. Rifalazil treats and prevents relapse of clostridium difficile-associated diarrhea in hamsters. Antimicrob Agents Chemother. 2004 Oct; 48(10):3975-9.
    View in: PubMed
  12. Eisenstein BI. Lipopeptides, focusing on daptomycin, for the treatment of Gram-positive infections. Expert Opin Investig Drugs. 2004 Sep; 13(9):1159-69.
    View in: PubMed
  13. Arbeit RD, Maki D, Tally FP, Campanaro E, Eisenstein BI. The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections. Clin Infect Dis. 2004 Jun 15; 38(12):1673-81.
    View in: PubMed
  14. Rothstein DM, Hartman AD, Cynamon MH, Eisenstein BI. Development potential of rifalazil. Expert Opin Investig Drugs. 2003 Feb; 12(2):255-71.
    View in: PubMed
  15. Ashburn TT, Wilson SK, Eisenstein BI. Human tissue research in the genomic era of medicine: balancing individual and societal interests. Arch Intern Med. 2000 Dec 11-25; 160(22):3377-84.
    View in: PubMed
  16. Baden LR, Eisenstein BI. Impact of Antibiotic Resistance on the Treatment of Gram-negative Sepsis. Curr Infect Dis Rep. 2000 Oct; 2(5):409-416.
    View in: PubMed
  17. Blomfield IC, Kulasekara DH, Eisenstein BI. Integration host factor stimulates both FimB- and FimE-mediated site-specific DNA inversion that controls phase variation of type 1 fimbriae expression in Escherichia coli. Mol Microbiol. 1997 Feb; 23(4):705-17.
    View in: PubMed
  18. Arroyo J, Hurley MC, Wolf M, McClain MS, Eisenstein BI, Engleberg NC. Shuttle mutagenesis of Legionella pneumophila: identification of a gene associated with host cell cytopathicity. Infect Immun. 1994 Sep; 62(9):4075-80.
    View in: PubMed
  19. Gally DL, Bogan JA, Eisenstein BI, Blomfield IC. Environmental regulation of the fim switch controlling type 1 fimbrial phase variation in Escherichia coli K-12: effects of temperature and media. J Bacteriol. 1993 Oct; 175(19):6186-93.
    View in: PubMed
  20. McClain MS, Blomfield IC, Eberhardt KJ, Eisenstein BI. Inversion-independent phase variation of type 1 fimbriae in Escherichia coli. J Bacteriol. 1993 Jul; 175(14):4335-44.
    View in: PubMed
  21. Mody CH, Paine R, Shahrabadi MS, Simon RH, Pearlman E, Eisenstein BI, Toews GB. Legionella pneumophila replicates within rat alveolar epithelial cells. J Infect Dis. 1993 May; 167(5):1138-45.
    View in: PubMed
  22. Abu Kwaik Y, Eisenstein BI, Engleberg NC. Phenotypic modulation by Legionella pneumophila upon infection of macrophages. Infect Immun. 1993 Apr; 61(4):1320-9.
    View in: PubMed
  23. Blomfield IC, Calie PJ, Eberhardt KJ, McClain MS, Eisenstein BI. Lrp stimulates phase variation of type 1 fimbriation in Escherichia coli K-12. J Bacteriol. 1993 Jan; 175(1):27-36.
    View in: PubMed
  24. Albano MA, Arroyo J, Eisenstein BI, Engleberg NC. PhoA gene fusions in Legionella pneumophila generated in vivo using a new transposon, MudphoA. Mol Microbiol. 1992 Jul; 6(13):1829-39.
    View in: PubMed
  25. Engleberg NC, Eisenstein BI. Detection of microbial nucleic acids for diagnostic purposes. Annu Rev Med. 1992; 43:147-55.
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  26. McClain MS, Blomfield IC, Eisenstein BI. Roles of fimB and fimE in site-specific DNA inversion associated with phase variation of type 1 fimbriae in Escherichia coli. J Bacteriol. 1991 Sep; 173(17):5308-14.
    View in: PubMed
  27. Blomfield IC, McClain MS, Princ JA, Calie PJ, Eisenstein BI. Type 1 fimbriation and fimE mutants of Escherichia coli K-12. J Bacteriol. 1991 Sep; 173(17):5298-307.
    View in: PubMed
  28. Engleberg NC, Howe DC, Rogers JE, Arroyo J, Eisenstein BI. Characterization of a Legionella pneumophila gene encoding a lipoprotein antigen. Mol Microbiol. 1991 Aug; 5(8):2021-9.
    View in: PubMed
  29. Blomfield IC, Vaughn V, Rest RF, Eisenstein BI. Allelic exchange in Escherichia coli using the Bacillus subtilis sacB gene and a temperature-sensitive pSC101 replicon. Mol Microbiol. 1991 Jun; 5(6):1447-57.
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  30. Blomfield IC, McClain MS, Eisenstein BI. Type 1 fimbriae mutants of Escherichia coli K12: characterization of recognized afimbriate strains and construction of new fim deletion mutants. Mol Microbiol. 1991 Jun; 5(6):1439-45.
    View in: PubMed
  31. Engleberg NC, Eisenstein BI. Progress in the pathogenesis of Legionella pneumophila. Microb Pathog. 1991 Jan; 10(1):11-3.
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  32. Eisenstein BI. New opportunistic infections--more opportunities. N Engl J Med. 1990 Dec 6; 323(23):1625-7.
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  33. Ofek I, Zafriri D, Goldhar J, Eisenstein BI. Inability of toxin inhibitors to neutralize enhanced toxicity caused by bacteria adherent to tissue culture cells. Infect Immun. 1990 Nov; 58(11):3737-42.
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  34. Cianciotto NP, Bangsborg JM, Eisenstein BI, Engleberg NC. Identification of mip-like genes in the genus Legionella. Infect Immun. 1990 Sep; 58(9):2912-8.
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  35. Cianciotto NP, Eisenstein BI, Mody CH, Engleberg NC. A mutation in the mip gene results in an attenuation of Legionella pneumophila virulence. J Infect Dis. 1990 Jul; 162(1):121-6.
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  36. Eisenstein BI. New molecular techniques for microbial epidemiology and the diagnosis of infectious diseases. J Infect Dis. 1990 Apr; 161(4):595-602.
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  37. Eisenstein BI. The polymerase chain reaction. A new method of using molecular genetics for medical diagnosis. N Engl J Med. 1990 Jan 18; 322(3):178-83.
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  38. Cianciotto N, Eisenstein BI, Engleberg NC, Shuman H. Genetics and molecular pathogenesis of Legionella pneumophila, an intracellular parasite of macrophages. Mol Biol Med. 1989 Oct; 6(5):409-24.
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  39. Engleberg NC, Carter C, Weber DR, Cianciotto NP, Eisenstein BI. DNA sequence of mip, a Legionella pneumophila gene associated with macrophage infectivity. Infect Immun. 1989 Apr; 57(4):1263-70.
    View in: PubMed
  40. Cianciotto NP, Eisenstein BI, Mody CH, Toews GB, Engleberg NC. A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection. Infect Immun. 1989 Apr; 57(4):1255-62.
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  41. Pearlman E, Jiwa AH, Engleberg NC, Eisenstein BI. Growth of Legionella pneumophila in a human macrophage-like (U937) cell line. Microb Pathog. 1988 Aug; 5(2):87-95.
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  42. Engleberg NC, Cianciotto N, Smith J, Eisenstein BI. Transfer and maintenance of small, mobilizable plasmids with ColE1 replication origins in Legionella pneumophila. Plasmid. 1988 Jul; 20(1):83-91.
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  43. Eisenstein BI. Type 1 fimbriae of Escherichia coli: genetic regulation, morphogenesis, and role in pathogenesis. Rev Infect Dis. 1988 Jul-Aug; 10 Suppl 2:S341-4.
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  44. Eisenstein BI, Jones GW. The spectrum of infections and pathogenic mechanisms of Escherichia coli. Adv Intern Med. 1988; 33:231-52.
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  45. Eisenstein BI, Sweet DS, Vaughn V, Friedman DI. Integration host factor is required for the DNA inversion that controls phase variation in Escherichia coli. Proc Natl Acad Sci U S A. 1987 Sep; 84(18):6506-10.
    View in: PubMed
  46. Zafriri D, Oron Y, Eisenstein BI, Ofek I. Growth advantage and enhanced toxicity of Escherichia coli adherent to tissue culture cells due to restricted diffusion of products secreted by the cells. J Clin Invest. 1987 Apr; 79(4):1210-6.
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  47. Lowe MA, Holt SC, Eisenstein BI. Immunoelectron microscopic analysis of elongation of type 1 fimbriae in Escherichia coli. J Bacteriol. 1987 Jan; 169(1):157-63.
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  48. Abraham JM, Freitag CS, Gander RM, Clements JR, Thomas VL, Eisenstein BI. Fimbrial phase variation and DNA rearrangements in uropathogenic isolates of Escherichia coli. Mol Biol Med. 1986 Dec; 3(6):495-508.
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  49. Engleberg NC, Carter C, Demarsh P, Drutz DJ, Eisenstein BI. A Legionella-specific DNA probe detects organisms in lung tissue homogenates from intranasally inoculated mice. Isr J Med Sci. 1986 Oct; 22(10):703-5.
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  50. Eisenstein BI, Engleberg NC. Applied molecular genetics: new tools for microbiologists and clinicians. J Infect Dis. 1986 Mar; 153(3):416-30.
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  51. Engleberg NC, Pearlman E, Dixon D, Eisenstein BI. Antibodies isolated by using cloned surface antigens recognize antigenically related components of Legionella pneumophila and other Legionella species. J Immunol. 1986 Feb 15; 136(4):1415-7.
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  52. Abraham JM, Freitag CS, Clements JR, Eisenstein BI. An invertible element of DNA controls phase variation of type 1 fimbriae of Escherichia coli. Proc Natl Acad Sci U S A. 1985 Sep; 82(17):5724-7.
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  53. Freitag CS, Abraham JM, Clements JR, Eisenstein BI. Genetic analysis of the phase variation control of expression of type 1 fimbriae in Escherichia coli. J Bacteriol. 1985 May; 162(2):668-75.
    View in: PubMed
  54. Pearlman E, Engleberg NC, Eisenstein BI. Identification of protein antigens of Legionella pneumophila serogroup 1. Infect Immun. 1985 Jan; 47(1):74-9.
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  55. Engleberg NC, Eisenstein BI. The impact of new cloning techniques on the diagnosis and treatment of infectious diseases. N Engl J Med. 1984 Oct 4; 311(14):892-901.
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  56. Dodd DC, Eisenstein BI. Kinetic analysis of the synthesis and assembly of type 1 fimbriae of Escherichia coli. J Bacteriol. 1984 Oct; 160(1):227-32.
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  57. Engleberg NC, Pearlman E, Eisenstein BI. Legionella pneumophila surface antigens cloned and expressed in Escherichia coli are translocated to the host cell surface and interact with specific anti-Legionella antibodies. J Bacteriol. 1984 Oct; 160(1):199-203.
    View in: PubMed
  58. Dodd DC, Bassford PJ, Eisenstein BI. Dependence of secretion and assembly of type 1 fimbrial subunits of Escherichia coli on normal protein export. J Bacteriol. 1984 Sep; 159(3):1077-9.
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  59. Engleberg NC, Drutz DJ, Eisenstein BI. Cloning and expression of Legionella pneumophila antigens in Escherichia coli. Infect Immun. 1984 May; 44(2):222-7.
    View in: PubMed
  60. Freitag CS, Eisenstein BI. Genetic mapping and transcriptional orientation of the fimD gene. J Bacteriol. 1983 Dec; 156(3):1052-8.
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  61. Eisenstein BI, Clements JR, Dodd DC. Isolation and characterization of a monoclonal antibody directed against type 1 fimbriae organelles from Escherichia coli. Infect Immun. 1983 Oct; 42(1):333-40.
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  62. Dodd DC, Eisenstein BI. Antigenic quantitation of type 1 fimbriae on the surface of Escherichia coli cells by an enzyme-linked immunosorbent inhibition assay. Infect Immun. 1982 Nov; 38(2):764-73.
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  63. Eisenstein BI, Dodd DC. Pseudocatabolite repression of type 1 fimbriae of Escherichia coli. J Bacteriol. 1982 Sep; 151(3):1560-7.
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  64. Eisenstein BI. Operon fusion of the phase variation switch. A virulence factor in Escherichia coli. Infection. 1982; 10(2):112-5.
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  65. Eisenstein BI, Beachey EH, Ofek I. Differential effects of antibiotics on adhesins of antibiotic resistant strains of Escherichia coli. Scand J Infect Dis Suppl. 1982; 33:108-14.
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  66. Eisenstein BI. Phase variation of type 1 fimbriae in Escherichia coli is under transcriptional control. Science. 1981 Oct 16; 214(4518):337-9.
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  67. Masi AT, Eisenstein BI. Disseminated gonococcal infection (DGI) and gonococcal arthritis (GCA): II. Clinical manifestations, diagnosis, complications, treatment, and prevention. Semin Arthritis Rheum. 1981 Feb; 10(3):173-97.
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  68. Eisenstein BI, Masi AT. Disseminated gonococcal infection (DGI) and gonococcal arthritis (GCA): I. Bacteriology, epidemiology, host factors, pathogen factors, and pathology. Semin Arthritis Rheum. 1981 Feb; 10(3):155-72.
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  69. Eisenstein BI, Ofek I, Beachey EH. Loss of lectin-like activity in aberrant type 1 fimbriae of Escherichia coli. Infect Immun. 1981 Feb; 31(2):792-7.
    View in: PubMed
  70. Beachey EH, Eisenstein BI, Ofek I. Sublethal concentrations of antibiotics and bacterial adhesion. Ciba Found Symp. 1981; 80:288-305.
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  71. Eisenstein BI, Beachey EH, Solomon SS. Divergent effects of cyclic adenosine 3',5'-monophosphate on formation of type 1 fimbriae in different K-12 strains of Escherichia coli. J Bacteriol. 1981 Jan; 145(1):620-3.
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  72. Eisenstein BI, Beachey EH, Ofek I. Influence of sublethal concentrations of antibiotics on the expression of the mannose-specific ligand of Escherichia coli. Infect Immun. 1980 Apr; 28(1):154-9.
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  73. Eisenstein BI. Bacterial variation and antibiotic action. Adv Intern Med. 1980; 26:393-426.
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  74. Ofek I, Beachey EH, Eisenstein BI, Alkan ML, Sharon N. Suppression of bacterial adherence by subminimal inhibitory concentrations of beta-lactam and aminoglycoside antibiotics. Rev Infect Dis. 1979 Sep-Oct; 1(5):832-7.
    View in: PubMed
  75. Eisenstein BI, Ofek I, Beachey EH. Interference with the mannose binding and epithelial cell adherence of Escherichia coli by sublethal concentrations of streptomycin. J Clin Invest. 1979 Jun; 63(6):1219-28.
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  76. Eisenstein BI, Sparling PF. Mutations to increased antibiotic sensitivity in naturally-occurring gonococci. Nature. 1978 Jan 19; 271(5642):242-4.
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  77. Eisenstein BI. Effective treatment of gonorrhoea. Drugs. 1977 Jul; 14(1):57-67.
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  78. Eisenstein BI, Sox T, Biswas G, Blackman E, Sparling PF. Conjugal transfer of the gonococcal penicillinase plasmid. Science. 1977 Mar 11; 195(4282):998-1000.
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  79. Eisenstein BI, Lee TJ, Sparling PF. Penicillin sensitivity and serum resistance are independent attributes of strains of Neisseria gonorrhoeae causing disseminated gonococcal infection. Infect Immun. 1977 Mar; 15(3):834-41.
    View in: PubMed
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