Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

David Borsook, Ph.D., M.B.,B.Ch.

TitleAssociate Professor of Anaesthesia
InstitutionChildren's Hospital Boston
DepartmentAnaesthesia
AddressChildren's Hospital
Division of Pain Medicine
9 Hope Avenue
Waltham MA 02453
Phone617/355-2303

 Mentoring 
 completed student projects
The Lateralization of Trigeminal Pain Processing in the Brain
Summer, 06/15/09 - 07/31/09

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Linnman C, Becerra L, Lebel A, Berde C, Grant PE, Borsook D. Transient and persistent pain induced connectivity alterations in pediatric complex regional pain syndrome. PLoS One. 2013; 8(3):e57205.
    View in: PubMed
  2. Borsook D, Kussman BD, George E, Becerra LR, Burke DW. Surgically induced neuropathic pain: understanding the perioperative process. Ann Surg. 2013 Mar; 257(3):403-12.
    View in: PubMed
  3. Bruehl S, Apkarian AV, Ballantyne JC, Berger A, Borsook D, Chen WG, Farrar JT, Haythornthwaite JA, Horn SD, Iadarola MJ, Inturrisi CE, Lao L, Mackey S, Mao J, Sawczuk A, Uhl GR, Witter J, Woolf CJ, Zubieta JK, Lin Y. Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges. J Pain. 2013 Feb; 14(2):103-13.
    View in: PubMed
  4. Becerra L, Upadhyay J, Chang PC, Bishop J, Anderson J, Baumgartner R, Schwarz AJ, Coimbra A, Wallin D, Nutile L, George E, Maier G, Sunkaraneni S, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Borsook D. Parallel Buprenorphine phMRI Responses in Conscious Rodents and Healthy Human Subjects. J Pharmacol Exp Ther. 2013 Apr; 345(1):41-51.
    View in: PubMed
  5. Gear R, Becerra L, Upadhyay J, Bishop J, Wallin D, Pendse G, Levine J, Borsook D. Pain facilitation brain regions activated by nalbuphine are revealed by pharmacological FMRI. PLoS One. 2013; 8(1):e50169.
    View in: PubMed
  6. Linnman C, Maleki N, Becerra L, Borsook D. Migraine Tweets - What can online behavior tell us about disease? Cephalalgia. 2013 Jan; 33(1):68-9.
    View in: PubMed
  7. Maleki N, Becerra L, Borsook D. Migraine: maladaptive brain responses to stress. Headache. 2012 Oct; 52 Suppl 2:102-6.
    View in: PubMed
  8. Moulton EA, Becerra L, Rosenthal P, Borsook D. An approach to localizing corneal pain representation in human primary somatosensory cortex. PLoS One. 2012; 7(9):e44643.
    View in: PubMed
  9. Maleki N, Linnman C, Brawn J, Burstein R, Becerra L, Borsook D. Her versus his migraine: multiple sex differences in brain function and structure. Brain. 2012 Aug; 135(Pt 8):2546-59.
    View in: PubMed
  10. Borsook D, Burstein R. The enigma of the dorsolateral pons as a migraine generator. Cephalalgia. 2012 Aug; 32(11):803-12.
    View in: PubMed
  11. Kurbanov DB, Currie PJ, Simonson DC, Borsook D, Elman I. Effects of naltrexone on food intake and body weight gain in olanzapine-treated rats. J Psychopharmacol. 2012 Sep; 26(9):1244-51.
    View in: PubMed
  12. Sprenger T, Borsook D. Migraine changes the brain: neuroimaging makes its mark. Curr Opin Neurol. 2012 Jun; 25(3):252-62.
    View in: PubMed
  13. Maleki N, Becerra L, Brawn J, Bigal M, Burstein R, Borsook D. Concurrent functional and structural cortical alterations in migraine. Cephalalgia. 2012 Jun; 32(8):607-20.
    View in: PubMed
  14. Borsook D, Upadhyay J, Klimas M, Schwarz AJ, Coimbra A, Baumgartner R, George E, Potter WZ, Large T, Bleakman D, Evelhoch J, Iyengar S, Becerra L, Hargreaves RJ. Decision-making using fMRI in clinical drug development: revisiting NK-1 receptor antagonists for pain. Drug Discov Today. 2012 Sep; 17(17-18):964-73.
    View in: PubMed
  15. Moulton EA, Pendse G, Becerra LR, Borsook D. BOLD responses in somatosensory cortices better reflect heat sensation than pain. J Neurosci. 2012 Apr 25; 32(17):6024-31.
    View in: PubMed
  16. Toledo E, Lebel A, Becerra L, Minster A, Linnman C, Maleki N, Dodick DW, Borsook D. The young brain and concussion: imaging as a biomarker for diagnosis and prognosis. Neurosci Biobehav Rev. 2012 Jul; 36(6):1510-31.
    View in: PubMed
  17. Borsook D. 'Hot feet - hot brain': gene and brain dysfunction in erythromelalgia. Pain. 2012 May; 153(5):945-7.
    View in: PubMed
  18. Shelton L, Pendse G, Maleki N, Moulton EA, Lebel A, Becerra L, Borsook D. Mapping pain activation and connectivity of the human habenula. J Neurophysiol. 2012 May; 107(10):2633-48.
    View in: PubMed
  19. Elman I, Becerra L, Tschibelu E, Yamamoto R, George E, Borsook D. Yohimbine-induced amygdala activation in pathological gamblers: a pilot study. PLoS One. 2012; 7(2):e31118.
    View in: PubMed
  20. Borsook D, Maleki N, Becerra L, McEwen B. Understanding migraine through the lens of maladaptive stress responses: a model disease of allostatic load. Neuron. 2012 Jan 26; 73(2):219-34.
    View in: PubMed
  21. Shelton L, Becerra L, Borsook D. Unmasking the mysteries of the habenula in pain and analgesia. Prog Neurobiol. 2012 Feb; 96(2):208-19.
    View in: PubMed
  22. Rosenthal P, Borsook D. The corneal pain system. Part I: the missing piece of the dry eye puzzle. Ocul Surf. 2012 Jan; 10(1):2-14.
    View in: PubMed
  23. Linnman C, Moulton EA, Barmettler G, Becerra L, Borsook D. Neuroimaging of the periaqueductal gray: state of the field. Neuroimage. 2012 Mar; 60(1):505-22.
    View in: PubMed
  24. Pendse GV, Borsook D, Becerra L. A simple and objective method for reproducible resting state network (RSN) detection in fMRI. PLoS One. 2011; 6(12):e27594.
    View in: PubMed
  25. Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Schwarz AJ, Pendse G, Wallin D, Nutile L, Bishop J, George E, Elman I, Sunkaraneni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Modulation of CNS pain circuitry by intravenous and sublingual doses of buprenorphine. Neuroimage. 2012 Feb 15; 59(4):3762-73.
    View in: PubMed
  26. Borsook D. Neurological diseases and pain. Brain. 2012 Feb; 135(Pt 2):320-44.
    View in: PubMed
  27. Becerra L, Pendse G, Chang PC, Bishop J, Borsook D. Robust reproducible resting state networks in the awake rodent brain. PLoS One. 2011; 6(10):e25701.
    View in: PubMed
  28. Noseda R, Jakubowski M, Kainz V, Borsook D, Burstein R. Cortical projections of functionally identified thalamic trigeminovascular neurons: implications for migraine headache and its associated symptoms. J Neurosci. 2011 Oct 5; 31(40):14204-17.
    View in: PubMed
  29. Maleki N, Becerra L, Nutile L, Pendse G, Brawn J, Bigal M, Burstein R, Borsook D. Migraine attacks the Basal Ganglia. Mol Pain. 2011; 7:71.
    View in: PubMed
  30. Upadhyay J, Anderson J, Schwarz AJ, Coimbra A, Baumgartner R, Pendse G, George E, Nutile L, Wallin D, Bishop J, Neni S, Maier G, Iyengar S, Evelhoch JL, Bleakman D, Hargreaves R, Becerra L, Borsook D. Imaging drugs with and without clinical analgesic efficacy. Neuropsychopharmacology. 2011 Dec; 36(13):2659-73.
    View in: PubMed
  31. Borsook D, Rosenthal P. Chronic (neuropathic) corneal pain and blepharospasm: five case reports. Pain. 2011 Oct; 152(10):2427-31.
    View in: PubMed
  32. Borsook D, Becerra L. How close are we in utilizing functional neuroimaging in routine clinical diagnosis of neuropathic pain? Curr Pain Headache Rep. 2011 Jun; 15(3):223-9.
    View in: PubMed
  33. Schwarz AJ, Becerra L, Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Evelhoch J, Hargreaves R, Robertson B, Iyengar S, Tauscher J, Bleakman D, Borsook D. A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #1: processes and requirements. Drug Discov Today. 2011 Jul; 16(13-14):583-93.
    View in: PubMed
  34. Schwarz AJ, Becerra L, Upadhyay J, Anderson J, Baumgartner R, Coimbra A, Evelhoch J, Hargreaves R, Robertson B, Iyengar S, Tauscher J, Bleakman D, Borsook D. A procedural framework for good imaging practice in pharmacological fMRI studies applied to drug development #2: protocol optimization and best practices. Drug Discov Today. 2011 Aug; 16(15-16):671-82.
    View in: PubMed
  35. Moulton EA, Elman I, Pendse G, Schmahmann J, Becerra L, Borsook D. Aversion-related circuitry in the cerebellum: responses to noxious heat and unpleasant images. J Neurosci. 2011 Mar 9; 31(10):3795-804.
    View in: PubMed
  36. Borsook D, Becerra L, Hargreaves R. Biomarkers for chronic pain and analgesia. Part 1: the need, reality, challenges, and solutions. Discov Med. 2011 Mar; 11(58):197-207.
    View in: PubMed
  37. Borsook D, Becerra L, Hargreaves R. Biomarkers for chronic pain and analgesia. Part 2: how, where, and what to look for using functional imaging. Discov Med. 2011 Mar; 11(58):209-19.
    View in: PubMed
  38. Maleki N, Becerra L, Upadhyay J, Burstein R, Borsook D. Direct optic nerve pulvinar connections defined by diffusion MR tractography in humans: implications for photophobia. Hum Brain Mapp. 2012 Jan; 33(1):75-88.
    View in: PubMed
  39. Elman I, Zubieta JK, Borsook D. The missing p in psychiatric training: why it is important to teach pain to psychiatrists. Arch Gen Psychiatry. 2011 Jan; 68(1):12-20.
    View in: PubMed
  40. Borsook D, Becerra L. CNS animal fMRI in pain and analgesia. Neurosci Biobehav Rev. 2011 Apr; 35(5):1125-43.
    View in: PubMed
  41. Borsook D, Hargreaves R. Brain imaging in migraine research. Headache. 2010 Oct; 50(9):1523-7.
    View in: PubMed
  42. Becerra L, Chang PC, Bishop J, Borsook D. CNS activation maps in awake rats exposed to thermal stimuli to the dorsum of the hindpaw. Neuroimage. 2011 Jan 15; 54(2):1355-66.
    View in: PubMed
  43. Borsook D, George E, Kussman B, Becerra L. Anesthesia and perioperative stress: consequences on neural networks and postoperative behaviors. Prog Neurobiol. 2010 Dec; 92(4):601-12.
    View in: PubMed
  44. Borsook D, Becerra L. Using NMR approaches to drive the search for new CNS therapeutics. Curr Opin Investig Drugs. 2010 Jul; 11(7):771-8.
    View in: PubMed
  45. Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R, Becerra L, Borsook D. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010 Jul; 68(1):81-91.
    View in: PubMed
  46. Elman I, Tschibelu E, Borsook D. Psychosocial stress and its relationship to gambling urges in individuals with pathological gambling. Am J Addict. 2010 Jul-Aug; 19(4):332-9.
    View in: PubMed
  47. Moulton EA, Becerra L, Maleki N, Pendse G, Tully S, Hargreaves R, Burstein R, Borsook D. Painful heat reveals hyperexcitability of the temporal pole in interictal and ictal migraine States. Cereb Cortex. 2011 Feb; 21(2):435-48.
    View in: PubMed
  48. Upadhyay J, Maleki N, Potter J, Elman I, Rudrauf D, Knudsen J, Wallin D, Pendse G, McDonald L, Griffin M, Anderson J, Nutile L, Renshaw P, Weiss R, Becerra L, Borsook D. Alterations in brain structure and functional connectivity in prescription opioid-dependent patients. Brain. 2010 Jul; 133(Pt 7):2098-114.
    View in: PubMed
  49. Pendse GV, Schwarz AJ, Baumgartner R, Coimbra A, Upadhyay J, Borsook D, Becerra L. Robust, unbiased general linear model estimation of phMRI signal amplitude in the presence of variation in the temporal response profile. J Magn Reson Imaging. 2010 Jun; 31(6):1445-57.
    View in: PubMed
  50. George E, Becerra L, Upadhyay J, Schmidt U, Borsook D. Evaluation of novel drugs using fMRI in early-phase clinical trials: safety monitoring. Drug Discov Today. 2010 Aug; 15(15-16):684-9.
    View in: PubMed
  51. Moulton EA, Schmahmann JD, Becerra L, Borsook D. The cerebellum and pain: passive integrator or active participator? Brain Res Rev. 2010 Oct 5; 65(1):14-27.
    View in: PubMed
  52. Borsook D, Upadhyay J, Chudler EH, Becerra L. A key role of the basal ganglia in pain and analgesia--insights gained through human functional imaging. Mol Pain. 2010; 6:27.
    View in: PubMed
  53. Scrivani S, Wallin D, Moulton EA, Cole S, Wasan AD, Lockerman L, Bajwa Z, Upadhyay J, Becerra L, Borsook D. A fMRI evaluation of lamotrigine for the treatment of trigeminal neuropathic pain: pilot study. Pain Med. 2010 Jun; 11(6):920-41.
    View in: PubMed
  54. Borsook D, Sava S, Becerra L. The pain imaging revolution: advancing pain into the 21st century. Neuroscientist. 2010 Apr; 16(2):171-85.
    View in: PubMed
  55. Pendse GV, Baumgartner R, Schwarz AJ, Coimbra A, Borsook D, Becerra L. A statistical framework for optimal design matrix generation with application to fMRI. IEEE Trans Med Imaging. 2010 Sep; 29(9):1573-611.
    View in: PubMed
  56. Becerra L, Harris W, Grant M, George E, Boas D, Borsook D. Diffuse optical tomography activation in the somatosensory cortex: specific activation by painful vs. non-painful thermal stimuli. PLoS One. 2009; 4(11):e8016.
    View in: PubMed
  57. Upadhyay J, Pendse G, Anderson J, Schwarz AJ, Baumgartner R, Coimbra A, Bishop J, Knudsen J, George E, Grachev I, Iyengar S, Bleakman D, Hargreaves R, Borsook D, Becerra L. Improved characterization of BOLD responses for evoked sensory stimuli. Neuroimage. 2010 Feb 1; 49(3):2275-86.
    View in: PubMed
  58. Moulton EA, Becerra L, Borsook D. An fMRI case report of photophobia: activation of the trigeminal nociceptive pathway. Pain. 2009 Oct; 145(3):358-63.
    View in: PubMed
  59. Borsook D. Ketamine and chronic pain--going the distance. Pain. 2009 Oct; 145(3):271-2.
    View in: PubMed
  60. Prescot A, Becerra L, Pendse G, Tully S, Jensen E, Hargreaves R, Renshaw P, Burstein R, Borsook D. Excitatory neurotransmitters in brain regions in interictal migraine patients. Mol Pain. 2009; 5:34.
    View in: PubMed
  61. Sava S, Lebel AA, Leslie DS, Drosos A, Berde C, Becerra L, Borsook D. Challenges of functional imaging research of pain in children. Mol Pain. 2009; 5:30.
    View in: PubMed
  62. Borsook D, Sava S. Pain: Do ACE inhibitors exacerbate complex regional pain syndrome? Nat Rev Neurol. 2009 Jun; 5(6):306-8.
    View in: PubMed
  63. Pendse G, Borsook D, Becerra L. Enhanced false discovery rate using Gaussian mixture models for thresholding fMRI statistical maps. Neuroimage. 2009 Aug 1; 47(1):231-61.
    View in: PubMed
  64. Moulton EA, Pendse G, Morris S, Aiello-Lammens M, Becerra L, Borsook D. Segmentally arranged somatotopy within the face representation of human primary somatosensory cortex. Hum Brain Mapp. 2009 Mar; 30(3):757-65.
    View in: PubMed
  65. Borsook D, Becerra L. Emotional pain without sensory pain--dream on? Neuron. 2009 Jan 29; 61(2):153-5.
    View in: PubMed
  66. Moulton EA, Burstein R, Tully S, Hargreaves R, Becerra L, Borsook D. Interictal dysfunction of a brainstem descending modulatory center in migraine patients. PLoS One. 2008; 3(11):e3799.
    View in: PubMed
  67. Upadhyay J, Knudsen J, Anderson J, Becerra L, Borsook D. Noninvasive mapping of human trigeminal brainstem pathways. Magn Reson Med. 2008 Nov; 60(5):1037-46.
    View in: PubMed
  68. DaSilva AF, Becerra L, Pendse G, Chizh B, Tully S, Borsook D. Colocalized structural and functional changes in the cortex of patients with trigeminal neuropathic pain. PLoS One. 2008; 3(10):e3396.
    View in: PubMed
  69. Bieber CM, Fernandez K, Borsook D, Brennan MJ, Butler SF, Jamison RN, Osgood E, Sharpe-Potter J, Thomson HN, Weiss RD, Katz NP. Retrospective accounts of initial subjective effects of opioids in patients treated for pain who do or do not develop opioid addiction: a pilot case-control study. Exp Clin Psychopharmacol. 2008 Oct; 16(5):429-34.
    View in: PubMed
  70. Lebel A, Becerra L, Wallin D, Moulton EA, Morris S, Pendse G, Jasciewicz J, Stein M, Aiello-Lammens M, Grant E, Berde C, Borsook D. fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children. Brain. 2008 Jul; 131(Pt 7):1854-79.
    View in: PubMed
  71. Borsook D, Bleakman D, Hargreaves R, Upadhyay J, Schmidt KF, Becerra L. A 'BOLD' experiment in defining the utility of fMRI in drug development. Neuroimage. 2008 Aug 15; 42(2):461-6.
    View in: PubMed
  72. Becerra L, Harris W, Joseph D, Huppert T, Boas DA, Borsook D. Diffuse optical tomography of pain and tactile stimulation: activation in cortical sensory and emotional systems. Neuroimage. 2008 Jun; 41(2):252-9.
    View in: PubMed
  73. Becerra L, Borsook D. Signal valence in the nucleus accumbens to pain onset and offset. Eur J Pain. 2008 Oct; 12(7):866-9.
    View in: PubMed
  74. Borsook D, Moulton EA, Tully S, Schmahmann JD, Becerra L. Human cerebellar responses to brush and heat stimuli in healthy and neuropathic pain subjects. Cerebellum. 2008; 7(3):252-72.
    View in: PubMed
  75. Grant PE, Gallagher J, Gonzalez RG, Borsook D. Adriamycin injection into the medial cord of the brachial plexus: computed tomography-guided targeted pain therapy. Pain Med. 2008 Jan-Feb; 9(1):83-7.
    View in: PubMed
  76. Borsook D, Moulton EA, Pendse G, Morris S, Cole SH, Aiello-Lammens M, Scrivani S, Becerra LR. Comparison of evoked vs. spontaneous tics in a patient with trigeminal neuralgia (tic doloureux). Mol Pain. 2007; 3:34.
    View in: PubMed
  77. Borsook D. Pain and motor system plasticity. Pain. 2007 Nov; 132(1-2):8-9.
    View in: PubMed
  78. Borsook D, Moulton EA, Schmidt KF, Becerra LR. Neuroimaging revolutionizes therapeutic approaches to chronic pain. Mol Pain. 2007; 3:25.
    View in: PubMed
  79. Borsook D, Becerra L. Phenotyping central nervous system circuitry in chronic pain using functional MRI: considerations and potential implications in the clinic. Curr Pain Headache Rep. 2007 Jun; 11(3):201-7.
    View in: PubMed
  80. DaSilva AF, Goadsby PJ, Borsook D. Cluster headache: a review of neuroimaging findings. Curr Pain Headache Rep. 2007 Apr; 11(2):131-6.
    View in: PubMed
  81. Moulton EA, Pendse G, Morris S, Strassman A, Aiello-Lammens M, Becerra L, Borsook D. Capsaicin-induced thermal hyperalgesia and sensitization in the human trigeminal nociceptive pathway: an fMRI study. Neuroimage. 2007 May 1; 35(4):1586-600.
    View in: PubMed
  82. Becerra L, Morris S, Bazes S, Gostic R, Sherman S, Gostic J, Pendse G, Moulton E, Scrivani S, Keith D, Chizh B, Borsook D. Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli. J Neurosci. 2006 Oct 18; 26(42):10646-57.
    View in: PubMed
  83. Borsook D, Becerra LR. Breaking down the barriers: fMRI applications in pain, analgesia and analgesics. Mol Pain. 2006; 2:30.
    View in: PubMed
  84. Becerra L, Harter K, Gonzalez RG, Borsook D. Functional magnetic resonance imaging measures of the effects of morphine on central nervous system circuitry in opioid-naive healthy volunteers. Anesth Analg. 2006 Jul; 103(1):208-16, table of contents.
    View in: PubMed
  85. Negus SS, Vanderah TW, Brandt MR, Bilsky EJ, Becerra L, Borsook D. Preclinical assessment of candidate analgesic drugs: recent advances and future challenges. J Pharmacol Exp Ther. 2006 Nov; 319(2):507-14.
    View in: PubMed
  86. Borsook D, Burstein R, Moulton E, Becerra L. Functional imaging of the trigeminal system: applications to migraine pathophysiology. Headache. 2006 Jun; 46 Suppl 1:S32-8.
    View in: PubMed
  87. Borsook D, Becerra L, Hargreaves R. A role for fMRI in optimizing CNS drug development. Nat Rev Drug Discov. 2006 May; 5(5):411-24.
    View in: PubMed
  88. Elman I, Borsook D, Lukas SE. Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agents. Neuropsychopharmacology. 2006 Oct; 31(10):2091-120.
    View in: PubMed
  89. Borsook D, Becerra L, Carlezon WA, Shaw M, Renshaw P, Elman I, Levine J. Reward-aversion circuitry in analgesia and pain: implications for psychiatric disorders. Eur J Pain. 2007 Jan; 11(1):7-20.
    View in: PubMed
  90. Aharon I, Becerra L, Becerraa L, Chabris CF, Borsook D, Borsooka D. Noxious heat induces fMRI activation in two anatomically distinct clusters within the nucleus accumbens. Neurosci Lett. 2006 Jan 16; 392(3):159-64.
    View in: PubMed
  91. Borsook D, Becerra L. Functional imaging of pain and analgesia--a valid diagnostic tool? Pain. 2005 Oct; 117(3):247-50.
    View in: PubMed
  92. Hama AT, Borsook D. The effect of antinociceptive drugs tested at different times after nerve injury in rats. Anesth Analg. 2005 Jul; 101(1):175-9, table of contents.
    View in: PubMed
  93. Hama AT, Borsook D. Behavioral and pharmacological characterization of a distal peripheral nerve injury in the rat. Pharmacol Biochem Behav. 2005 May; 81(1):170-81.
    View in: PubMed
  94. Borsook D, Burstein R, Becerra L. Functional imaging of the human trigeminal system: opportunities for new insights into pain processing in health and disease. J Neurobiol. 2004 Oct; 61(1):107-25.
    View in: PubMed
  95. Borras MC, Becerra L, Ploghaus A, Gostic JM, DaSilva A, Gonzalez RG, Borsook D. fMRI measurement of CNS responses to naloxone infusion and subsequent mild noxious thermal stimuli in healthy volunteers. J Neurophysiol. 2004 Jun; 91(6):2723-33.
    View in: PubMed
  96. Borsook D, Edwards AD. Antineuropathic effects of the antibiotic derivative spicamycin KRN5500. Pain Med. 2004 Mar; 5(1):104-8.
    View in: PubMed
  97. Becerra L, Iadarola M, Borsook D. CNS activation by noxious heat to the hand or foot: site-dependent delay in sensory but not emotion circuitry. J Neurophysiol. 2004 Jan; 91(1):533-41.
    View in: PubMed
  98. Borsook D, Becerra L. Pain imaging: future applications to integrative clinical and basic neurobiology. Adv Drug Deliv Rev. 2003 Aug 28; 55(8):967-86.
    View in: PubMed
  99. Borsook D. Pain: the past, present and future. Adv Drug Deliv Rev. 2003 Aug 28; 55(8):931-4.
    View in: PubMed
  100. Borsook D, DaSilva AF, Ploghaus A, Becerra L. Specific and somatotopic functional magnetic resonance imaging activation in the trigeminal ganglion by brush and noxious heat. J Neurosci. 2003 Aug 27; 23(21):7897-903.
    View in: PubMed
  101. Kobierski LA, Abdi S, DiLorenzo L, Feroz N, Borsook D. A single intravenous injection of KRN5500 (antibiotic spicamycin) produces long-term decreases in multiple sensory hypersensitivities in neuropathic pain. Anesth Analg. 2003 Jul; 97(1):174-82, table of contents.
    View in: PubMed
  102. Ploghaus A, Becerra L, Borras C, Borsook D. Neural circuitry underlying pain modulation: expectation, hypnosis, placebo. Trends Cogn Sci. 2003 May; 7(5):197-200.
    View in: PubMed
  103. DaSilva AF, Becerra L, Makris N, Strassman AM, Gonzalez RG, Geatrakis N, Borsook D. Somatotopic activation in the human trigeminal pain pathway. J Neurosci. 2002 Sep 15; 22(18):8183-92.
    View in: PubMed
  104. DiLorenzo L, Kobierski L, Moore KA, Borsook D. A water-soluble synthetic spicamycin derivative (San-Gly) decreases mechanical allodynia in a rodent model of neuropathic pain. Neurosci Lett. 2002 Sep 13; 330(1):37-40.
    View in: PubMed
  105. Borsook D, Ploghaus A, Becerra L. Utilizing brain imaging for analgesic drug development. Curr Opin Investig Drugs. 2002 Sep; 3(9):1342-7.
    View in: PubMed
  106. Becerra L, Breiter HC, Wise R, Gonzalez RG, Borsook D. Reward circuitry activation by noxious thermal stimuli. Neuron. 2001 Dec 6; 32(5):927-46.
    View in: PubMed
  107. Fishman SM, Wilsey B, Yang J, Reisfield GM, Bandman TB, Borsook D. Adherence monitoring and drug surveillance in chronic opioid therapy. J Pain Symptom Manage. 2000 Oct; 20(4):293-307.
    View in: PubMed
  108. Abdi S, Vilassova N, Decosterd I, Feroz N, Borsook D. The effects of KRN5500, a spicamycin derivative, on neuropathic and nociceptive pain models in rats. Anesth Analg. 2000 Oct; 91(4):955-9.
    View in: PubMed
  109. Tracey I, Becerra L, Chang I, Breiter H, Jenkins L, Borsook D, González RG. Noxious hot and cold stimulation produce common patterns of brain activation in humans: a functional magnetic resonance imaging study. Neurosci Lett. 2000 Jul 14; 288(2):159-62.
    View in: PubMed
  110. Kobierski LA, Srivastava S, Borsook D. Systemic lipopolysaccharide and interleukin-1beta activate the interleukin 6: STAT intracellular signaling pathway in neurons of mouse trigeminal ganglion. Neurosci Lett. 2000 Mar 3; 281(1):61-4.
    View in: PubMed
  111. Kobierski LA, Wong AE, Srivastava S, Borsook D, Hyman SE. Cyclic AMP-dependent activation of the proenkephalin gene requires phosphorylation of CREB at serine-133 and a Src-related kinase. J Neurochem. 1999 Jul; 73(1):129-38.
    View in: PubMed
  112. Fishman SM, Bandman TB, Edwards A, Borsook D. The opioid contract in the management of chronic pain. J Pain Symptom Manage. 1999 Jul; 18(1):27-37.
    View in: PubMed
  113. Becerra LR, Breiter HC, Stojanovic M, Fishman S, Edwards A, Comite AR, Gonzalez RG, Borsook D. Human brain activation under controlled thermal stimulation and habituation to noxious heat: an fMRI study. Magn Reson Med. 1999 May; 41(5):1044-57.
    View in: PubMed
  114. Van Koughnet K, Smirnova O, Hyman SE, Borsook D. Proenkephalin transgene regulation in the paraventricular nucleus of the hypothalamus by lipopolysaccharide and interleukin-1beta. J Comp Neurol. 1999 Mar 8; 405(2):199-215.
    View in: PubMed
  115. Borsook D, Smirnova O, Behar O, Lewis S, Kobierski LA. PhosphoCREB and CREM/ICER: positive and negative regulation of proenkephalin gene expression in the paraventricular nucleus of the hypothalamus. J Mol Neurosci. 1999 Feb; 12(1):35-51.
    View in: PubMed
  116. Fishman SM, Caneris OA, Bandman TB, Audette JF, Borsook D. Injection of the piriformis muscle by fluoroscopic and electromyographic guidance. Reg Anesth Pain Med. 1998 Nov-Dec; 23(6):554-9.
    View in: PubMed
  117. Borsook D, Becerra L, Fishman S, Edwards A, Jennings CL, Stojanovic M, Papinicolas L, Ramachandran VS, Gonzalez RG, Breiter H. Acute plasticity in the human somatosensory cortex following amputation. Neuroreport. 1998 Apr 20; 9(6):1013-7.
    View in: PubMed
  118. Borsook D, Falkowski O, Smirnova O. Proenkephalin gene regulation in the paraventricular nucleus by GABA: interactions with opioid systems in a transgenic model. J Neurochem. 1998 Feb; 70(2):604-16.
    View in: PubMed
  119. Fishman SM, Caneris OA, Stojanovic MP, Borsook D. Intravenous lidocaine for treatment-resistant pruritus. Am J Med. 1997 Jun; 102(6):584-5.
    View in: PubMed
  120. Priest CA, Borsook D, Pfaff DW. Estrogen and stress interact to regulate the hypothalamic expression of a human proenkephalin promoter-beta-galactosidase fusion gene in a site-specific and sex-specific manner. J Neuroendocrinol. 1997 Apr; 9(4):317-26.
    View in: PubMed
  121. Manfredi PL, Borsook D, Chandler SW, Payne R. Intravenous methadone for cancer pain unrelieved by morphine and hydromorphone: clinical observations. Pain. 1997 Mar; 70(1):99-101.
    View in: PubMed
  122. Fishman SM, Catarau EM, Sachs G, Stojanovic M, Borsook D. Corticosteroid-induced mania after single regional application at the celiac plexus. Anesthesiology. 1996 Nov; 85(5):1194-6.
    View in: PubMed
  123. Burstein R, Falkowsky O, Borsook D, Strassman A. Distinct lateral and medial projections of the spinohypothalamic tract of the rat. J Comp Neurol. 1996 Sep 30; 373(4):549-74.
    View in: PubMed
  124. Hyman SE, Borsook D. Mechanisms regulating proenkephalin gene expression: contributions of transgenic models. NIDA Res Monogr. 1996; 161:59-71.
    View in: PubMed
  125. Borsook D, Hyman SE. Proenkephalin gene regulation in the neuroendocrine hypothalamus: a model of gene regulation in the CNS. Am J Physiol. 1995 Sep; 269(3 Pt 1):E393-408.
    View in: PubMed
  126. Borsook D, Falkowski O, Rosen H, Comb M, Hyman SE. Opioids modulate stress-induced proenkephalin gene expression in the hypothalamus of transgenic mice: a model of endogenous opioid gene regulation by exogenous opioids. J Neurosci. 1994 Dec; 14(12):7261-71.
    View in: PubMed
  127. Borsook D, Konradi C, Falkowski O, Comb M, Hyman SE. Molecular mechanisms of stress-induced proenkephalin gene regulation: CREB interacts with the proenkephalin gene in the mouse hypothalamus and is phosphorylated in response to hyperosmolar stress. Mol Endocrinol. 1994 Feb; 8(2):240-8.
    View in: PubMed
  128. Borsook D, Falkowski O, Burstein R, Strassman A, Konradi C, Dauber A, Comb M, Hyman SE. Stress-induced regulation of a human proenkephalin-beta-galactosidase fusion gene in the hypothalamus of transgenic mice. Mol Endocrinol. 1994 Jan; 8(1):116-25.
    View in: PubMed
  129. Strassman AM, Vos BP, Mineta Y, Naderi S, Borsook D, Burstein R. Fos-like immunoreactivity in the superficial medullary dorsal horn induced by noxious and innocuous thermal stimulation of facial skin in the rat. J Neurophysiol. 1993 Nov; 70(5):1811-21.
    View in: PubMed
  130. Borsook D, Rosen H, Collard M, Dressler H, Herrup K, Comb MJ, Hyman SE. Expression and regulation of a proenkephalin beta-galactosidase fusion gene in the reproductive system of transgenic mice. Mol Endocrinol. 1992 Sep; 6(9):1502-12.
    View in: PubMed
  131. Comb MJ, Kobierski L, Chu HM, Tan Y, Borsook D, Herrup K, Hyman SE. Regulation of opioid gene expression: a model to understand neural plasticity. NIDA Res Monogr. 1992; 126:98-112.
    View in: PubMed
  132. Borsook D, Richardson GS, Moore-Ede MC, Brennan MJ. GABA and circadian timekeeping: implications for manic-depression and sleep disorders. Med Hypotheses. 1986 Feb; 19(2):185-98.
    View in: PubMed
  133. Brennan MJ, Volicer L, Moore-Ede MC, Borsook D. Daily rhythms of benzodiazepine receptor numbers in frontal lobe and cerebellum of the rat. Life Sci. 1985 Jun 17; 36(24):2333-7.
    View in: PubMed
  134. Mannell A, Borsook D, Diamantes T. Recurrent ulceration and hypergastrinaemia in the gastrectomized patient. An approach to diagnosis. S Afr J Surg. 1983 Mar; 21(1):35-42.
    View in: PubMed
  135. Borsook D, Laburn H, Mitchell D. The febrile responses in rabbits and rats to leucocyte pyrogens of different species. J Physiol. 1978 Jun; 279:113-20.
    View in: PubMed
  136. Borsook D, Laburn HP, Rosendorff C, Willies GH, Woolf CJ. A dissociation between temperature regulation and fever in the rabbit. J Physiol. 1977 Apr; 266(2):423-33.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Borsook's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
See all (474) concept(s)
_
Co-Authors
See all (37) people
_
Similar People
See all (60) people
_
Same Department
Search Department
Physical Neighbors
_