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Leo Cheng, Ph.D.

TitleAssociate Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
Pathology Research CNY-7, 149-7151
149 13th Street
Charlestown MA 02129
Phone617/724-6593
Fax617/726-5684

 Mentoring 
 completed student projects
Metabolic Characterization of Human Oral Squamous Cell Carcinoma Using Tissue Magnetic Resonance Spectroscopy
Summer, 06/24/05 - 08/19/05

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wu CC, Lin YM, Gao J, Winston JH, Cheng LK, Shi XZ. Are interstitial cells of cajal involved in mechanical stress-induced gene expression and impairment of smooth muscle contractility in bowel obstruction? PLoS One. 2013; 8(9):e76222.
    View in: PubMed
  2. Angeli TR, O'Grady G, Paskaranandavadivel N, Erickson JC, Du P, Pullan AJ, Bissett IP, Cheng LK. Experimental and Automated Analysis Techniques for High-resolution Electrical Mapping of Small Intestine Slow Wave Activity. J Neurogastroenterol Motil. 2013 Apr; 19(2):179-91.
    View in: PubMed
  3. Spur EM, Decelle EA, Cheng LL. Metabolomic imaging of prostate cancer with magnetic resonance spectroscopy and mass spectrometry. Eur J Nucl Med Mol Imaging. 2013 Jul; 40 Suppl 1:60-71.
    View in: PubMed
  4. Decelle EA, Cheng LL. High-resolution magic angle spinning (1) H MRS in prostate cancer. NMR Biomed. 2014 Jan; 27(1):90-9.
    View in: PubMed
  5. O'Grady G, Angeli TR, Du P, Lahr C, Lammers WJ, Windsor JA, Abell TL, Farrugia G, Pullan AJ, Cheng LK. Abnormal initiation and conduction of slow-wave activity in gastroparesis, defined by high-resolution electrical mapping. Gastroenterology. 2012 Sep; 143(3):589-98.e1-3.
    View in: PubMed
  6. Jordan KW, Adkins CB, Cheng LL, Faquin WC. Application of magnetic-resonance-spectroscopy- based metabolomics to the fine-needle aspiration diagnosis of papillary thyroid carcinoma. Acta Cytol. 2011; 55(6):584-9.
    View in: PubMed
  7. Kurth J, Defeo E, Cheng LL. Magnetic resonance spectroscopy: a promising tool for the diagnostics of human prostate cancer? Urol Oncol. 2011 Sep-Oct; 29(5):562-71.
    View in: PubMed
  8. DeFeo EM, Wu CL, McDougal WS, Cheng LL. A decade in prostate cancer: from NMR to metabolomics. Nat Rev Urol. 2011 Jun; 8(6):301-11.
    View in: PubMed
  9. Paskaranandavadivel N, Cheng LK, Du P, O'Grady G, Pullan AJ. Improved signal processing techniques for the analysis of high resolution serosal slow wave activity in the stomach. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1737-40.
    View in: PubMed
  10. Bull SH, O'Grady G, Cheng LK, Pullan AJ. A framework for the online analysis of multi-electrode gastric slow wave recordings. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1741-4.
    View in: PubMed
  11. Erickson JC, O'Grady G, Du P, Egbuji JU, Pullan AJ, Cheng LK. Automated gastric slow wave cycle partitioning and visualization for high-resolution activation time maps. Ann Biomed Eng. 2011 Jan; 39(1):469-83.
    View in: PubMed
  12. DeFeo EM, Cheng LL. Characterizing human cancer metabolomics with ex vivo 1H HRMAS MRS. Technol Cancer Res Treat. 2010 Aug; 9(4):381-91.
    View in: PubMed
  13. O'Grady G, Du P, Cheng LK, Egbuji JU, Lammers WJ, Windsor JA, Pullan AJ. Origin and propagation of human gastric slow-wave activity defined by high-resolution mapping. Am J Physiol Gastrointest Liver Physiol. 2010 Sep; 299(3):G585-92.
    View in: PubMed
  14. Kaul D, Wu CL, Adkins CB, Jordan KW, Defeo EM, Habbel P, Peterson RT, McDougal WS, Pohl U, Cheng LL. Assessing prostate cancer growth with mRNA of spermine metabolic enzymes. Cancer Biol Ther. 2010 May; 9(9):736-42.
    View in: PubMed
  15. Maxeiner A, Adkins CB, Zhang Y, Taupitz M, Halpern EF, McDougal WS, Wu CL, Cheng LL. Retrospective analysis of prostate cancer recurrence potential with tissue metabolomic profiles. Prostate. 2010 May 15; 70(7):710-7.
    View in: PubMed
  16. Wu CL, Jordan KW, Ratai EM, Sheng J, Adkins CB, Defeo EM, Jenkins BG, Ying L, McDougal WS, Cheng LL. Metabolomic imaging for human prostate cancer detection. Sci Transl Med. 2010 Jan 27; 2(16):16ra8.
    View in: PubMed
  17. Erickson JC, O'Grady G, Du P, Obioha C, Qiao W, Richards WO, Bradshaw LA, Pullan AJ, Cheng LK. Falling-edge, variable threshold (FEVT) method for the automated detection of gastric slow wave events in high-resolution serosal electrode recordings. Ann Biomed Eng. 2010 Apr; 38(4):1511-29.
    View in: PubMed
  18. Jordan KW, Nordenstam J, Lauwers GY, Rothenberger DA, Alavi K, Garwood M, Cheng LL. Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy. Dis Colon Rectum. 2009 Mar; 52(3):520-5.
    View in: PubMed
  19. Du P, Qiao W, O'Grady G, Egbuji JU, Lammers W, Cheng LK, Pullan AJ. Automated detection of gastric slow wave events and estimation of propagation velocity vector fields from serosal high-resolution mapping. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:2527-30.
    View in: PubMed
  20. Jordan KW, Cheng LL. NMR-based metabolomics approach to target biomarkers for human prostate cancer. Expert Rev Proteomics. 2007 Jun; 4(3):389-400.
    View in: PubMed
  21. Jordan KW, He W, Halpern EF, Wu CL, Cheng LL. Evaluation of Tissue Metabolites with High Resolution Magic Angle Spinning MR Spectroscopy Human Prostate Samples After Three-Year Storage at -80 degrees C. Biomark Insights. 2007; 2:147-54.
    View in: PubMed
  22. Loening NM, Chamberlin AM, Zepeda AG, Gonzalez RG, Cheng LL. Quantification of phosphocholine and glycerophosphocholine with 31P edited 1H NMR spectroscopy. NMR Biomed. 2005 Nov; 18(7):413-20.
    View in: PubMed
  23. Burns MA, Taylor JL, Wu CL, Zepeda AG, Bielecki A, Cory D, Cheng LL. Reduction of spinning sidebands in proton NMR of human prostate tissue with slow high-resolution magic angle spinning. Magn Reson Med. 2005 Jul; 54(1):34-42.
    View in: PubMed
  24. Cheng LL, Burns MA, Taylor JL, He W, Halpern EF, McDougal WS, Wu CL. Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy. Cancer Res. 2005 Apr 15; 65(8):3030-4.
    View in: PubMed
  25. Burns MA, He W, Wu CL, Cheng LL. Quantitative pathology in tissue MR spectroscopy based human prostate metabolomics. Technol Cancer Res Treat. 2004 Dec; 3(6):591-8.
    View in: PubMed
  26. Wu CL, Taylor JL, He W, Zepeda AG, Halpern EF, Bielecki A, Gonzalez RG, Cheng LL. Proton high-resolution magic angle spinning NMR analysis of fresh and previously frozen tissue of human prostate. Magn Reson Med. 2003 Dec; 50(6):1307-11.
    View in: PubMed
  27. Taylor JL, Wu CL, Cory D, Gonzalez RG, Bielecki A, Cheng LL. High-resolution magic angle spinning proton NMR analysis of human prostate tissue with slow spinning rates. Magn Reson Med. 2003 Sep; 50(3):627-32.
    View in: PubMed
  28. Cheng LL, Newell K, Mallory AE, Hyman BT, Gonzalez RG. Quantification of neurons in Alzheimer and control brains with ex vivo high resolution magic angle spinning proton magnetic resonance spectroscopy and stereology. Magn Reson Imaging. 2002 Sep; 20(7):527-33.
    View in: PubMed
  29. Tzika AA, Cheng LL, Goumnerova L, Madsen JR, Zurakowski D, Astrakas LG, Zarifi MK, Scott RM, Anthony DC, Gonzalez RG, Black PM. Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy. J Neurosurg. 2002 Jun; 96(6):1023-31.
    View in: PubMed
  30. Cheng LL, Wu C, Smith MR, Gonzalez RG. Non-destructive quantitation of spermine in human prostate tissue samples using HRMAS 1H NMR spectroscopy at 9.4 T. FEBS Lett. 2001 Apr 6; 494(1-2):112-6.
    View in: PubMed
  31. Cheng LL, Chang IW, Smith BL, Gonzalez RG. Evaluating human breast ductal carcinomas with high-resolution magic-angle spinning proton magnetic resonance spectroscopy. J Magn Reson. 1998 Nov; 135(1):194-202.
    View in: PubMed
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