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Last Name

Xiaobo Zhou, Ph.D.

TitleInstructor in Medicine
InstitutionBrigham and Women's Hospital
AddressBrigham and Women's Hospital
Channing Division of Network Medicine
181 Longwood Ave
Boston MA 02115

Over last decade, Dr. Zhou has developed strong interest to dissect the functions of candidate genes identified from genetics studies in complex disease. With the rapid progress in high-throughput sequencing, there is increasing number of genetics regions associated with complex traits identified from human population. However, on the other side, relatively specified low-throughput functional assays limit our progress to transform genetics information to understand the disease pathobiology. The Functional Respiratory Genetics Laboratory led by Dr. Zhou are interested to address those fundamental questions that how genetic variants affects disease susceptibilities, mainly asthma and Chronic Obstructive Pulmonary Disease(COPD). There are several research directions in Dr Zhou's laboratory 1) Through histone modification and chromatin structure analysis to localize functional variants from the GWAS regions and follow up with validation in vitro and in vivo; 2) understand and distangle the gene-by-environmental interactions from molecular level by Chromatin Immunoprcipitation(ChIP) followed by next-generation sequencing; 3) develop new approaches to localize the regulatory elements in the GWAS regions to facilitate us to understand the mechanism of how causal variants function; 4)dissect the role of the COPD and asthma susceptible genes in vitro by combining gene transcriptome profiling induced by “loss-of-function” and protein-protein interaction network; 5) fully investigate the role of COPD candidate genes in smoke induced emphysema model.

 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Li C, Zhou X, Sun Y, Zhang E, Mancini JD, Parkhitko A, Morrison TA, Silverman EK, Henske EP, Yu JJ. Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):135-42.
    View in: PubMed
  2. Zhou X, Qiu W, Sathirapongsasuti JF, Cho MH, Mancini JD, Lao T, Thibault DM, Litonjua AA, Bakke PS, Gulsvik A, Lomas DA, Beaty TH, Hersh CP, Anderson C, Geigenmuller U, Raby BA, Rennard SI, Perrella MA, Choi AM, Quackenbush J, Silverman EK. Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells. Genomics. 2013 May; 101(5):263-72.
    View in: PubMed
  3. Li W, Liu H, Zhou JS, Cao JF, Zhou XB, Choi AM, Chen ZH, Shen HH. Caveolin-1 inhibits expression of antioxidant enzymes through direct interaction with nuclear erythroid 2 p45-related factor-2 (Nrf2). J Biol Chem. 2012 Jun 15; 287(25):20922-30.
    View in: PubMed
  4. Zhou X, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AM, Silverman EK. Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet. 2012 Mar 15; 21(6):1325-35.
    View in: PubMed
  5. Lange NE, Zhou X, Lasky-Su J, Himes BE, Lazarus R, Soto-Quirós M, Avila L, Celedón JC, Hawrylowicz CM, Raby BA, Litonjua AA. Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes. BMC Med Genet. 2011; 12:26.
    View in: PubMed
  6. Zhou X, Münger K. Clld7, a candidate tumor suppressor on chromosome 13q14, regulates pathways of DNA damage/repair and apoptosis. Cancer Res. 2010 Nov 15; 70(22):9434-43.
    View in: PubMed
  7. Zhou X, Spangle JM, Münger K. Expression of a viral oncoprotein in normal human epithelial cells triggers an autophagy-related process: is autophagy an "Achilles' heel" of human cancers? Autophagy. 2009 May; 5(4):578-9.
    View in: PubMed
  8. Zhou X, Münger K. Expression of the human papillomavirus type 16 E7 oncoprotein induces an autophagy-related process and sensitizes normal human keratinocytes to cell death in response to growth factor deprivation. Virology. 2009 Mar 1; 385(1):192-7.
    View in: PubMed
  9. Huh K, Zhou X, Hayakawa H, Cho JY, Libermann TA, Jin J, Harper JW, Munger K. . The Human Papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor. J of Virology. 2007; 81(18):9737-47.
  10. Yang SB, Zhou XB, Zhu HX, Quan LP, Bai JF, He J, Gao YN, Cheng SJ, Xu NZ. Amplification and overexpression of Aurora-A in esophageal squamous cell carcinoma. Oncol Rep. 2007 May; 17(5):1083-8.
    View in: PubMed
  11. Wang Y, Hewitt SM, Liu S, Zhou X, Zhu H, Zhou C, Zhang G, Quan L, Bai J, Xu N. Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localisation of beta-catenin in ovarian tumours. Br J Cancer. 2006 Mar 13; 94(5):686-91.
    View in: PubMed
  12. Wang Y, Zhou X, Zhu H, Liu S, Zhou C, Zhang G, Xue L, Lu N, Quan L, Bai J, Zhan Q, Xu N. Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC) may promote cellular growth by activating beta-catenin/TCF pathway. Oncogene. 2005 Oct 6; 24(44):6637-45.
    View in: PubMed
  13. Zhang G, Zhou X, Xue L, Quan L, Wang Y, Zhou C, Lu N, Wang Q, Zhu H, Xu N. Accumulation of cytoplasmic beta-catenin correlates with reduced expression of E-cadherin, but not with phosphorylated Akt in esophageal squamous cell carcinoma: immunohistochemical study. Pathol Int. 2005 Jun; 55(6):310-7.
    View in: PubMed
  14. Zhou C, Liu S, Zhou X, Xue L, Quan L, Lu N, Zhang G, Bai J, Wang Y, Liu Z, Zhan Q, Zhu H, Xu N. . Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by beta-catenin/TCF pathway in human esophageal squamous cell carcinoma. International Journal of Cancer. 2005; 113(6):891-898.
  15. Wang YH, Liu S, Zhang G, Zhou CQ, Zhu HX, Zhou XB, Quan LP, Bai JF, Xu NZ. Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo. Breast Cancer Res. 2005; 7(2):R220-8.
    View in: PubMed
  16. Zhou XB, Guo M, Quan LP, Zhang W, Lu ZM, Wang QH, Ke Y, Xu NZ. Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium. World J Gastroenterol. 2003 Jun; 9(6):1170-3.
    View in: PubMed
  17. Zhou X, Lu N, Zhang W, Quan LP, Lin DM, Wang QH, Li YL, Xu NZ. . Expression and significance of beta-catenin in esophageal carcinoma. Ai Zheng,. 2002; 21(8):877-880.
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