Xiaobo Zhou, Ph.D.
|Title||Instructor in Medicine|
|Institution||Brigham and Women's Hospital|
|Address||Brigham and Women's Hospital|
Channing Division of Network Medicine
181 Longwood Ave
Boston MA 02115
Over last decade, Dr. Zhou has developed strong interest to dissect the functions of candidate genes identified from genetics studies in complex disease. With the rapid progress in high-throughput sequencing, there is increasing number of genetics regions associated with complex traits identified from human population. However, on the other side, relatively specified low-throughput functional assays limit our progress to transform genetics information to understand the disease pathobiology. The Functional Respiratory Genetics Laboratory led by Dr. Zhou are interested to address those fundamental questions that how genetic variants affects disease susceptibilities, mainly asthma and Chronic Obstructive Pulmonary Disease(COPD). There are several research directions in Dr Zhou's laboratory 1) Through histone modification and chromatin structure analysis to localize functional variants from the GWAS regions and follow up with validation in vitro and in vivo; 2) understand and distangle the gene-by-environmental interactions from molecular level by Chromatin Immunoprcipitation(ChIP) followed by next-generation sequencing; 3) develop new approaches to localize the regulatory elements in the GWAS regions to facilitate us to understand the mechanism of how causal variants function; 4)dissect the role of the COPD and asthma susceptible genes in vitro by combining gene transcriptome profiling induced by “loss-of-function” and protein-protein interaction network; 5) fully investigate the role of COPD candidate genes in smoke induced emphysema model.
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