Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Stephen Paul Soltoff, PH.D.

TitleAssistant Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Division of Signal Transduction, EC/CLS-406
330 Brookline Ave
Boston MA 02215
Phone617/735-2640
Fax617/735-2646

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V, Signoretti S, Soltoff SP, Cantley LC. Identification of CDCP1 as a hypoxia-inducible factor 2a (HIF-2a) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc Natl Acad Sci U S A. 2013 Feb 26; 110(9):3483-8.
    View in: PubMed
  2. Benes CH, Poulogiannis G, Cantley LC, Soltoff SP. The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility. Oncogene. 2012 Feb 2; 31(5):653-63.
    View in: PubMed
  3. Hedden L, Benes CH, Soltoff SP. P2X(7) receptor antagonists display agonist-like effects on cell signaling proteins. Biochim Biophys Acta. 2011 May; 1810(5):532-42.
    View in: PubMed
  4. Soltoff SP, Asara JM, Hedden L. Regulation and identification of Na,K-ATPase alpha1 subunit phosphorylation in rat parotid acinar cells. J Biol Chem. 2010 Nov 19; 285(47):36330-8.
    View in: PubMed
  5. Soltoff SP, Hedden L. Isoproterenol and cAMP block ERK phosphorylation and enhance [Ca2+]i increases and oxygen consumption by muscarinic receptor stimulation in rat parotid and submandibular acinar cells. J Biol Chem. 2010 Apr 30; 285(18):13337-48.
    View in: PubMed
  6. Soltoff SP, Hedden L. Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells. Am J Physiol Cell Physiol. 2008 Sep; 295(3):C590-9.
    View in: PubMed
  7. Soltoff SP. Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta. Trends Pharmacol Sci. 2007 Sep; 28(9):453-8.
    View in: PubMed
  8. Plourde D, Soltoff SP. Ouabain potentiates the activation of ERK1/2 by carbachol in parotid gland epithelial cells; inhibition of ERK1/2 reduces Na(+)-K(+)-ATPase activity. Am J Physiol Cell Physiol. 2006 Mar; 290(3):C702-10.
    View in: PubMed
  9. Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, Soltoff SP. The C2 domain of PKCdelta is a phosphotyrosine binding domain. Cell. 2005 Apr 22; 121(2):271-80.
    View in: PubMed
  10. Soltoff SP. Evidence that tyrphostins AG10 and AG18 are mitochondrial uncouplers that alter phosphorylation-dependent cell signaling. J Biol Chem. 2004 Mar 19; 279(12):10910-8.
    View in: PubMed
  11. Bradford MD, Soltoff SP. P2X7 receptors activate protein kinase D and p42/p44 mitogen-activated protein kinase (MAPK) downstream of protein kinase C. Biochem J. 2002 Sep 15; 366(Pt 3):745-55.
    View in: PubMed
  12. Godwin SL, Soltoff SP. Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts. Bone. 2002 Apr; 30(4):559-66.
    View in: PubMed
  13. Singh VP, Saluja AK, Bhagat L, van Acker GJ, Song AM, Soltoff SP, Cantley LC, Steer ML. Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. J Clin Invest. 2001 Nov; 108(9):1387-95.
    View in: PubMed
  14. Soltoff SP. Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation. J Biol Chem. 2001 Oct 12; 276(41):37986-92.
    View in: PubMed
  15. Benes C, Soltoff SP. Modulation of PKCdelta tyrosine phosphorylation and activity in salivary and PC-12 cells by Src kinases. Am J Physiol Cell Physiol. 2001 Jun; 280(6):C1498-510.
    View in: PubMed
  16. Warny M, Aboudola S, Robson SC, Sévigny J, Communi D, Soltoff SP, Kelly CP. P2Y(6) nucleotide receptor mediates monocyte interleukin-8 production in response to UDP or lipopolysaccharide. J Biol Chem. 2001 Jul 13; 276(28):26051-6.
    View in: PubMed
  17. Benes C, Zheng Y, Soltoff SP. Activation of PKCdelta by tyrosine phosphorylation in rat parotid acinar cells. J Korean Med Sci. 2000 Aug; 15 Suppl:S40-1.
    View in: PubMed
  18. Zhang Z, Yang XY, Soltoff SP, Cohen DM. PI3K signaling in the murine kidney inner medullary cell response to urea. Am J Physiol Renal Physiol. 2000 Jan; 278(1):F155-64.
    View in: PubMed
  19. DeMali KA, Godwin SL, Soltoff SP, Kazlauskas A. Multiple roles for Src in a PDGF-stimulated cell. Exp Cell Res. 1999 Nov 25; 253(1):271-9.
    View in: PubMed
  20. Soltoff SP. Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activation. J Biol Chem. 1998 Sep 4; 273(36):23110-7.
    View in: PubMed
  21. Bradford MD, Soltoff SP. Involvement of protein kinases and phosphatases in tyrosine phosphorylation of PKCdelta in rat parotid acinar cells exposed to secretory stimuli. Eur J Morphol. 1998 Aug; 36 Suppl:176-80.
    View in: PubMed
  22. Soltoff SP, Grubman SA, Jefferson DM. Development of salivary gland cell lines for studies of signaling and physiology. Ann N Y Acad Sci. 1998 Apr 15; 842:100-7.
    View in: PubMed
  23. Soltoff SP, Avraham H, Avraham S, Cantley LC. Activation of P2Y2 receptors by UTP and ATP stimulates mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C. J Biol Chem. 1998 Jan 30; 273(5):2653-60.
    View in: PubMed
  24. Yoon SO, Soltoff SP, Chao MV. A dominant role of the juxtamembrane region of the TrkA nerve growth factor receptor during neuronal cell differentiation. J Biol Chem. 1997 Sep 12; 272(37):23231-8.
    View in: PubMed
  25. Godwin SL, Soltoff SP. Extracellular calcium and platelet-derived growth factor promote receptor-mediated chemotaxis in osteoblasts through different signaling pathways. J Biol Chem. 1997 Apr 25; 272(17):11307-12.
    View in: PubMed
  26. D'Mello SR, Borodezt K, Soltoff SP. Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling. J Neurosci. 1997 Mar 1; 17(5):1548-60.
    View in: PubMed
  27. Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H. p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem. 1996 Feb 9; 271(6):3187-94.
    View in: PubMed
  28. Soltoff SP, Cantley LC. p120cbl is a cytosolic adapter protein that associates with phosphoinositide 3-kinase in response to epidermal growth factor in PC12 and other cells. J Biol Chem. 1996 Jan 5; 271(1):563-7.
    View in: PubMed
  29. Fukazawa T, Reedquist KA, Panchamoorthy G, Soltoff S, Trub T, Druker B, Cantley L, Shoelson SE, Band H. T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38. J Biol Chem. 1995 Aug 25; 270(34):20177-82.
    View in: PubMed
  30. Fukazawa T, Reedquist KA, Trub T, Soltoff S, Panchamoorthy G, Druker B, Cantley L, Shoelson SE, Band H. The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. J Biol Chem. 1995 Aug 11; 270(32):19141-50.
    View in: PubMed
  31. Soltoff SP, Toker A. Carbachol, substance P, and phorbol ester promote the tyrosine phosphorylation of protein kinase C delta in salivary gland epithelial cells. J Biol Chem. 1995 Jun 2; 270(22):13490-5.
    View in: PubMed
  32. Wolkoff LI, Perrone RD, Grubman SA, Lee DW, Soltoff SP, Rogers LC, Beinborn M, Fang SL, Cheng SH, Jefferson DM. Purinoceptor P2U identification and function in human intrahepatic biliary epithelial cell lines. Cell Calcium. 1995 May; 17(5):375-83.
    View in: PubMed
  33. Carraway KL, Soltoff SP, Diamonti AJ, Cantley LC. Heregulin stimulates mitogenesis and phosphatidylinositol 3-kinase in mouse fibroblasts transfected with erbB2/neu and erbB3. J Biol Chem. 1995 Mar 31; 270(13):7111-6.
    View in: PubMed
  34. Soltoff SP, Carraway KL, Prigent SA, Gullick WG, Cantley LC. ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor. Mol Cell Biol. 1994 Jun; 14(6):3550-8.
    View in: PubMed
  35. Tuveson DA, Carter RH, Soltoff SP, Fearon DT. CD19 of B cells as a surrogate kinase insert region to bind phosphatidylinositol 3-kinase. Science. 1993 May 14; 260(5110):986-9.
    View in: PubMed
  36. Soltoff SP, McMillian MK, Talamo BR, Cantley LC. Blockade of ATP binding site of P2 purinoceptors in rat parotid acinar cells by isothiocyanate compounds. Biochem Pharmacol. 1993 May 5; 45(9):1936-40.
    View in: PubMed
  37. Lu M, Soltoff SP, Yaney GC, Boyd AE. The mechanisms underlying the glucose dependence of arginine vasopressin-induced insulin secretion in beta-cells. Endocrinology. 1993 May; 132(5):2141-8.
    View in: PubMed
  38. McMillian MK, Soltoff SP, Cantley LC, Rudel R, Talamo BR. Two distinct cytosolic calcium responses to extracellular ATP in rat parotid acinar cells. Br J Pharmacol. 1993 Feb; 108(2):453-61.
    View in: PubMed
  39. Soltoff SP, Rabin SL, Cantley LC, Kaplan DR. Nerve growth factor promotes the activation of phosphatidylinositol 3-kinase and its association with the trk tyrosine kinase. J Biol Chem. 1992 Aug 25; 267(24):17472-7.
    View in: PubMed
  40. Soltoff SP, McMillian MK, Talamo BR. ATP activates a cation-permeable pathway in rat parotid acinar cells. Am J Physiol. 1992 Apr; 262(4 Pt 1):C934-40.
    View in: PubMed
  41. Soltoff SP, Carpenter CL, Auger KR, Kapeller R, Schaffhausen B, Cantley LC. Phosphatidylinositol-3 kinase and growth regulation. Cold Spring Harb Symp Quant Biol. 1992; 57:75-80.
    View in: PubMed
  42. Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S. Oncogenes and signal transduction. Cell. 1991 Jan 25; 64(2):281-302.
    View in: PubMed
  43. Soltoff SP, McMillian MK, Cragoe EJ, Cantley LC, Talamo BR. Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol. J Gen Physiol. 1990 Feb; 95(2):319-46.
    View in: PubMed
  44. Soltoff SP, McMillian MK, Lechleiter JD, Cantley LC, Talamo BR. Elevation of [Ca2+]i and the activation of ion channels and fluxes by extracellular ATP and phospholipase C-linked agonists in rat parotid acinar cells. Ann N Y Acad Sci. 1990; 603:76-90; discussion 91-2.
    View in: PubMed
  45. Soltoff SP, McMillian MK, Talamo BR. Coomassie Brilliant Blue G is a more potent antagonist of P2 purinergic responses than Reactive Blue 2 (Cibacron Blue 3GA) in rat parotid acinar cells. Biochem Biophys Res Commun. 1989 Dec 29; 165(3):1279-85.
    View in: PubMed
  46. Auger KR, Serunian LA, Soltoff SP, Libby P, Cantley LC. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells. Cell. 1989 Apr 7; 57(1):167-75.
    View in: PubMed
  47. Soltoff SP, McMillian MK, Cantley LC, Cragoe EJ, Talamo BR. Effects of muscarinic, alpha-adrenergic, and substance P agonists and ionomycin on ion transport mechanisms in the rat parotid acinar cell. The dependence of ion transport on intracellular calcium. J Gen Physiol. 1989 Feb; 93(2):285-319.
    View in: PubMed
  48. McMillian MK, Soltoff SP, Lechleiter JD, Cantley LC, Talamo BR. Extracellular ATP increases free cytosolic calcium in rat parotid acinar cells. Differences from phospholipase C-linked receptor agonists. Biochem J. 1988 Oct 1; 255(1):291-300.
    View in: PubMed
  49. McMillian MK, Soltoff SP, Talamo BR. Mediation of norepinephrine effects on free cytosolic calcium in rat parotid acinar cells by alpha 1 adrenergic receptors. Biochem Pharmacol. 1988 Oct 1; 37(19):3790-3.
    View in: PubMed
  50. Mandel LJ, Takano T, Soltoff SP, Murdaugh S. Mechanisms whereby exogenous adenine nucleotides improve rabbit renal proximal function during and after anoxia. J Clin Invest. 1988 Apr; 81(4):1255-64.
    View in: PubMed
  51. Soltoff SP, Cantley LC. Mitogens and ion fluxes. Annu Rev Physiol. 1988; 50:207-23.
    View in: PubMed
  52. McMillian MK, Soltoff SP, Cantley LC, Talamo BR. Extracellular ATP elevates intracellular free calcium in rat parotid acinar cells. Biochem Biophys Res Commun. 1987 Dec 16; 149(2):523-30.
    View in: PubMed
  53. McMillian MK, Soltoff SP, Talamo BR. Rapid desensitization of substance P- but not carbachol-induced increases in inositol trisphosphate and intracellular Ca++ in rat parotid acinar cells. Biochem Biophys Res Commun. 1987 Nov 13; 148(3):1017-24.
    View in: PubMed
  54. Soltoff SP. Coupling renal metabolism to ion transport in renal epithelia. Semin Nephrol. 1987 Mar; 7(1):20-8.
    View in: PubMed
  55. Mandel LJ, Takano T, Soltoff SP, Jacobs WR, LeFurgey A, Ingram P. Multiple roles of calcium in anoxic-induced injury in renal proximal tubules. Soc Gen Physiol Ser. 1987; 42:277-85.
    View in: PubMed
  56. Soltoff SP, Cragoe EJ, Mandel LJ. Amiloride analogues inhibit proximal tubule metabolism. Am J Physiol. 1986 May; 250(5 Pt 1):C744-7.
    View in: PubMed
  57. Soltoff SP. ATP and the regulation of renal cell function. Annu Rev Physiol. 1986; 48:9-31.
    View in: PubMed
  58. Soltoff SP, Mandel LJ. Potassium transport in the rabbit renal proximal tubule: effects of barium, ouabain, valinomycin, and other ionophores. J Membr Biol. 1986; 94(2):153-61.
    View in: PubMed
  59. Mandel LJ, Soltoff SP, Brazy PC. Energy compartmentation and active transport in proximal kidney tubules. Adv Exp Med Biol. 1986; 194:213-28.
    View in: PubMed
  60. Takano T, Soltoff SP, Murdaugh S, Mandel LJ. Lowered oxygen supply and calcium (Ca) accumulation in rabbit proximal tubules. Adv Exp Med Biol. 1986; 200:485-6.
    View in: PubMed
  61. Takano T, Soltoff SP, Murdaugh S, Mandel LJ. Intracellular respiratory dysfunction and cell injury in short-term anoxia of rabbit renal proximal tubules. J Clin Invest. 1985 Dec; 76(6):2377-84.
    View in: PubMed
  62. Soltoff SP, Mandel LJ. Active ion transport in the renal proximal tubule. II. Ionic dependence of the Na pump. J Gen Physiol. 1984 Oct; 84(4):623-42.
    View in: PubMed
  63. Soltoff SP, Mandel LJ. Active ion transport in the renal proximal tubule. I. Transport and metabolic studies. J Gen Physiol. 1984 Oct; 84(4):601-22.
    View in: PubMed
  64. Brazy PC, Mandel LJ, Gullans SR, Soltoff SP. Interactions between phosphate and oxidative metabolism in proximal renal tubules. Am J Physiol. 1984 Oct; 247(4 Pt 2):F575-81.
    View in: PubMed
  65. Soltoff SP, Mandel LJ. Active ion transport in the renal proximal tubule. III. The ATP dependence of the Na pump. J Gen Physiol. 1984 Oct; 84(4):643-62.
    View in: PubMed
  66. Soltoff SP, Mandel LJ. Amiloride directly inhibits the Na,K-ATPase activity of rabbit kidney proximal tubules. Science. 1983 May 27; 220(4600):957-8.
    View in: PubMed
  67. Gullans SR, Brazy PC, Soltoff SP, Dennis VW, Mandel LJ. Metabolic inhibitors: effects on metabolism and transport in the proximal tubule. Am J Physiol. 1982 Aug; 243(2):F133-40.
    View in: PubMed
  68. Balaban RS, Mandel LJ, Soltoff SP, Storey JM. Coupling of active ion transport and aerobic respiratory rate in isolated renal tubules. Proc Natl Acad Sci U S A. 1980 Jan; 77(1):447-51.
    View in: PubMed
  69. Balaban RS, Soltoff SP, Storey JM, Mandel LJ. Improved renal cortical tubule suspension: spectrophotometric study of O2 delivery. Am J Physiol. 1980 Jan; 238(1):F50-9.
    View in: PubMed
  70. Soltoff S, Carcillo J, Coburn RF. Zero extracellular K+ and prostaglandin E release in the guinea-pig taenia coli. Biochim Biophys Acta. 1979 Oct 19; 557(1):217-29.
    View in: PubMed
  71. Klein LS, Fisher AB, Soltoff S, Coburn RF. Effect of O2 exposure on pulmonary metabolism of prostaglandin E2. Am Rev Respir Dis. 1978 Sep; 118(3):622-5.
    View in: PubMed
  72. Lippe MS, Gassman JI, Soltoff SP, King DB. Thyroidal influence on the lactate dehydrogenase isozyme pattern in pectoralis muscle of chick embryos. Gen Comp Endocrinol. 1977 Nov; 33(3):405-11.
    View in: PubMed
  73. Coburn RF, Soltoff S. Na+-K+-ATPase inhibition stimulates PGE release in guinea pig taenia coli. Am J Physiol. 1977 May; 232(5):C191-5.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Soltoff's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
See all (380) concept(s)
_
Co-Authors
See all (17) people
_
Similar People
See all (60) people
_
Same Department
Search Department
Physical Neighbors
_