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Last Name
Institution

Mary Larsen Bouxsein, PH.D.

TitleAssistant Professor of Orthopedic Surgery
InstitutionBeth Israel Deaconess Medical Center
DepartmentOrthopedic Surgery
AddressBeth Israel Deaconess Med Ctr
Orthopedic Biomechanics Lab, RN 115
330 Brookline Ave
Boston MA 02215
Phone617/667-4594
Fax617/667-7175

 Mentoring 
 completed student projects
the Role of Beta-Arrestin 2 in Regulating the Response of Bone to Parathyroid Hormone (PTH) Administration
Summer, 06/01/01 - 08/01/01
Effect of Age-, Sex- and Location-Specific Differences in Trunk Muscle Geometry on Estimates of Loading in the Thoracic and Lumbar Spine
Summer, 06/02/08 - 09/01/08

 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nawathe S, Akhlaghpour H, Bouxsein ML, Keaveny TM. Microstructural failure mechanisms in the human proximal femur for sideways fall loading. J Bone Miner Res. 2014 Feb; 29(2):507-15.
    View in: PubMed
  2. Sung M, Li J, Spieker AJ, Spatz J, Ellman R, Ferguson VL, Bateman TA, Rosen GD, Bouxsein M, Rutkove SB. Spaceflight and hind limb unloading induce similar changes in electrical impedance characteristics of mouse gastrocnemius muscle. J Musculoskelet Neuronal Interact. 2013 Dec; 13(4):405-11.
    View in: PubMed
  3. Putman MS, Yu EW, Lee H, Neer RM, Schindler E, Taylor AP, Cheston E, Bouxsein ML, Finkelstein JS. Differences in skeletal microarchitecture and strength in African-American and white women. J Bone Miner Res. 2013 Oct; 28(10):2177-85.
    View in: PubMed
  4. Mao XW, Pecaut MJ, Stodieck LS, Ferguson VL, Bateman TA, Bouxsein M, Jones TA, Moldovan M, Cunningham CE, Chieu J, Gridley DS. Spaceflight environment induces mitochondrial oxidative damage in ocular tissue. Radiat Res. 2013 Oct; 180(4):340-50.
    View in: PubMed
  5. Motyl KJ, Bishop KA, Demambro VE, Bornstein SA, Le P, Kawai M, Lotinun S, Horowitz MC, Baron R, Bouxsein ML, Rosen CJ. Altered thermogenesis and impaired bone remodeling in Misty mice. J Bone Miner Res. 2013 Sep; 28(9):1885-97.
    View in: PubMed
  6. Kacena MA, Gundberg CM, Kacena WJ, Landis WJ, Boskey AL, Bouxsein ML, Horowitz MC. The effects of GATA-1 and NF-E2 deficiency on bone biomechanical, biochemical, and mineral properties. J Cell Physiol. 2013 Jul; 228(7):1594-600.
    View in: PubMed
  7. Bernhard JM, Edgcomb VP, Visscher PT, McIntyre-Wressnig A, Summons RE, Bouxsein ML, Louis L, Jeglinski M. Insights into foraminiferal influences on microfabrics of microbialites at Highborne Cay, Bahamas. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9830-4.
    View in: PubMed
  8. Fazeli PK, Ackerman KE, Pierce L, Guereca G, Bouxsein M, Misra M. Sclerostin and Pref-1 have differential effects on bone mineral density and strength parameters in adolescent athletes compared with non-athletes. Osteoporos Int. 2013 Sep; 24(9):2433-40.
    View in: PubMed
  9. Rozental TD, Deschamps LN, Taylor A, Earp B, Zurakowski D, Day CS, Bouxsein ML. Premenopausal Women with a Distal Radial Fracture Have Deteriorated Trabecular Bone Density and Morphology Compared with Controls without a Fracture. J Bone Joint Surg Am. 2013 Apr 3; 95(7):633-42.
    View in: PubMed
  10. Ellman R, Spatz J, Cloutier A, Palme R, Christiansen BA, Bouxsein ML. Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass. J Bone Miner Res. 2013 Apr; 28(4):875-85.
    View in: PubMed
  11. Spatz JM, Ellman R, Cloutier AM, Louis L, van Vliet M, Suva LJ, Dwyer D, Stolina M, Ke HZ, Bouxsein ML. Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading. J Bone Miner Res. 2013 Apr; 28(4):865-74.
    View in: PubMed
  12. Faje AT, Karim L, Taylor A, Lee H, Miller KK, Mendes N, Meenaghan E, Goldstein MA, Bouxsein ML, Misra M, Klibanski A. Adolescent girls with anorexia nervosa have impaired cortical and trabecular microarchitecture and lower estimated bone strength at the distal radius. J Clin Endocrinol Metab. 2013 May; 98(5):1923-9.
    View in: PubMed
  13. Devlin MJ, Grasemann C, Cloutier AM, Louis L, Alm C, Palmert MR, Bouxsein ML. Maternal perinatal diet induces developmental programming of bone architecture. J Endocrinol. 2013; 217(1):69-81.
    View in: PubMed
  14. Roux JP, Wegrzyn J, Boutroy S, Bouxsein ML, Hans D, Chapurlat R. The predictive value of trabecular bone score (TBS) on whole lumbar vertebrae mechanics: an ex vivo study. Osteoporos Int. 2013 Sep; 24(9):2455-60.
    View in: PubMed
  15. Burghardt AJ, Pialat JB, Kazakia GJ, Boutroy S, Engelke K, Patsch JM, Valentinitsch A, Liu D, Szabo E, Bogado CE, Zanchetta MB, McKay HA, Shane E, Boyd SK, Bouxsein ML, Chapurlat R, Khosla S, Majumdar S. Multicenter precision of cortical and trabecular bone quality measures assessed by high-resolution peripheral quantitative computed tomography. J Bone Miner Res. 2013 Mar; 28(3):524-36.
    View in: PubMed
  16. Lawson EA, Ackerman KE, Estella NM, Guereca G, Pierce L, Sluss PM, Bouxsein ML, Klibanski A, Misra M. Nocturnal oxytocin secretion is lower in amenorrheic athletes than nonathletes and associated with bone microarchitecture and finite element analysis parameters. Eur J Endocrinol. 2013; 168(3):457-64.
    View in: PubMed
  17. Lewiecki EM, Adler RA, Bilezikian JP, Bouxsein ML, Marcus R, McClung MR, Miller PD, Tanner SB, Randall S. Osteoporosis update from the 2012 santa fe bone symposium. J Clin Densitom. 2013 Oct-Dec; 16(4):584-600.
    View in: PubMed
  18. Fajardo RJ, Desilva JM, Manoharan RK, Schmitz JE, Maclatchy LM, Bouxsein ML. Lumbar vertebral body bone microstructural scaling in small to medium-sized strepsirhines. Anat Rec (Hoboken). 2013 Feb; 296(2):210-26.
    View in: PubMed
  19. Grasemann C, Devlin MJ, Rzeczkowska PA, Herrmann R, Horsthemke B, Hauffa BP, Grynpas M, Alm C, Bouxsein ML, Palmert MR. Parental diabetes: the akita mouse as a model of the effects of maternal and paternal hyperglycemia in wildtype offspring. PLoS One. 2012; 7(11):e50210.
    View in: PubMed
  20. Bruno AG, Anderson DE, D'Agostino J, Bouxsein ML. The effect of thoracic kyphosis and sagittal plane alignment on vertebral compressive loading. J Bone Miner Res. 2012 Oct; 27(10):2144-51.
    View in: PubMed
  21. Bredella MA, Lin E, Gerweck AV, Landa MG, Thomas BJ, Torriani M, Bouxsein ML, Miller KK. Determinants of bone microarchitecture and mechanical properties in obese men. J Clin Endocrinol Metab. 2012 Nov; 97(11):4115-22.
    View in: PubMed
  22. Anderson DE, D'Agostino JM, Bruno AG, Demissie S, Kiel DP, Bouxsein ML. Variations of CT-Based Trunk Muscle Attenuation by Age, Sex, and Specific Muscle. J Gerontol A Biol Sci Med Sci. 2013 Mar; 68(3):317-23.
    View in: PubMed
  23. Ackerman KE, Putman M, Guereca G, Taylor AP, Pierce L, Herzog DB, Klibanski A, Bouxsein M, Misra M. Cortical microstructure and estimated bone strength in young amenorrheic athletes, eumenorrheic athletes and non-athletes. Bone. 2012 Oct; 51(4):680-7.
    View in: PubMed
  24. Braun TP, Orwoll B, Zhu X, Levasseur PR, Szumowski M, Nguyen ML, Bouxsein ML, Klein RF, Marks DL. Regulation of lean mass, bone mass, and exercise tolerance by the central melanocortin system. PLoS One. 2012; 7(7):e42183.
    View in: PubMed
  25. Portero-Muzy NR, Chavassieux PM, Bouxsein ML, Gineyts E, Garnero P, Chapurlat RD. Early effects of zoledronic acid and teriparatide on bone microarchitecture, remodeling and collagen crosslinks: comparison between iliac crest and lumbar vertebra in ewes. Bone. 2012 Oct; 51(4):714-9.
    View in: PubMed
  26. Spatz JM, Fields EE, Yu EW, Divieti Pajevic P, Bouxsein ML, Sibonga JD, Zwart SR, Smith SM. Serum sclerostin increases in healthy adult men during bed rest. J Clin Endocrinol Metab. 2012 Sep; 97(9):E1736-40.
    View in: PubMed
  27. Baud'huin M, Solban N, Cornwall-Brady M, Sako D, Kawamoto Y, Liharska K, Lath D, Bouxsein ML, Underwood KW, Ucran J, Kumar R, Pobre E, Grinberg A, Seehra J, Canalis E, Pearsall RS, Croucher PI. A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12207-12.
    View in: PubMed
  28. Pierroz DD, Bonnet N, Bianchi EN, Bouxsein ML, Baldock PA, Rizzoli R, Ferrari SL. Deletion of ß-adrenergic receptor 1, 2, or both leads to different bone phenotypes and response to mechanical stimulation. J Bone Miner Res. 2012 Jun; 27(6):1252-62.
    View in: PubMed
  29. Devlin MJ, Bouxsein ML. Reply to the Letter to the Editor "Peripartum nutrition and adult bone health". Bone. 2012 Jul; 51(1):186.
    View in: PubMed
  30. Liu CT, Karasik D, Zhou Y, Hsu YH, Genant HK, Broe KE, Lang TF, Samelson EJ, Demissie S, Bouxsein ML, Cupples LA, Kiel DP. Heritability of prevalent vertebral fracture and volumetric bone mineral density and geometry at the lumbar spine in three generations of the Framingham study. J Bone Miner Res. 2012 Apr; 27(4):954-8.
    View in: PubMed
  31. Samelson EJ, Christiansen BA, Demissie S, Broe KE, Louie-Gao Q, Cupples LA, Roberts BJ, Manoharam R, D'Agostino J, Lang T, Kiel DP, Bouxsein ML. QCT measures of bone strength at the thoracic and lumbar spine: the Framingham Study. J Bone Miner Res. 2012 Mar; 27(3):654-63.
    View in: PubMed
  32. Lane SW, De Vita S, Alexander KA, Karaman R, Milsom MD, Dorrance AM, Purdon A, Louis L, Bouxsein ML, Williams DA. Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development. Blood. 2012 Jan 19; 119(3):736-44.
    View in: PubMed
  33. Guntur AR, Kawai M, Le P, Bouxsein ML, Bornstein S, Green CB, Rosen CJ. An essential role for the circadian-regulated gene nocturnin in osteogenesis: the importance of local timekeeping in skeletal homeostasis. Ann N Y Acad Sci. 2011 Nov; 1237:58-63.
    View in: PubMed
  34. Anderson DE, D'Agostino JM, Bruno AG, Manoharan RK, Bouxsein ML. Regressions for estimating muscle parameters in the thoracic and lumbar trunk for use in musculoskeletal modeling. J Biomech. 2012 Jan 3; 45(1):66-75.
    View in: PubMed
  35. Kim YM, Demissie S, Genant HK, Cheng X, Yu W, Samelson EJ, Kiel DP, Bouxsein ML. Identification of prevalent vertebral fractures using CT lateral scout views: a comparison of semi-automated quantitative vertebral morphometry and radiologist semi-quantitative grading. Osteoporos Int. 2012 Mar; 23(3):1007-16.
    View in: PubMed
  36. Ackerman KE, Nazem T, Chapko D, Russell M, Mendes N, Taylor AP, Bouxsein ML, Misra M. Bone microarchitecture is impaired in adolescent amenorrheic athletes compared with eumenorrheic athletes and nonathletic controls. J Clin Endocrinol Metab. 2011 Oct; 96(10):3123-33.
    View in: PubMed
  37. Boonen S, Wahl DA, Nauroy L, Brandi ML, Bouxsein ML, Goldhahn J, Lewiecki EM, Lyritis GP, Marsh D, Obrant K, Silverman S, Siris E, Akesson K. Balloon kyphoplasty and vertebroplasty in the management of vertebral compression fractures. Osteoporos Int. 2011 Dec; 22(12):2915-34.
    View in: PubMed
  38. Bouxsein ML. Bone structure and fracture risk: do they go arm in arm? J Bone Miner Res. 2011 Jul; 26(7):1389-91.
    View in: PubMed
  39. Devlin MJ, Bouxsein ML. Influence of pre- and peri-natal nutrition on skeletal acquisition and maintenance. Bone. 2012 Feb; 50(2):444-51.
    View in: PubMed
  40. Christiansen BA, Kopperdahl DL, Kiel DP, Keaveny TM, Bouxsein ML. Mechanical contributions of the cortical and trabecular compartments contribute to differences in age-related changes in vertebral body strength in men and women assessed by QCT-based finite element analysis. J Bone Miner Res. 2011 May; 26(5):974-83.
    View in: PubMed
  41. Wegrzyn J, Roux JP, Arlot ME, Boutroy S, Vilayphiou N, Guyen O, Delmas PD, Chapurlat R, Bouxsein ML. Determinants of the mechanical behavior of human lumbar vertebrae after simulated mild fracture. J Bone Miner Res. 2011 Apr; 26(4):739-46.
    View in: PubMed
  42. Kawai M, Breggia AC, DeMambro VE, Shen X, Canalis E, Bouxsein ML, Beamer WG, Clemmons DR, Rosen CJ. The heparin-binding domain of IGFBP-2 has insulin-like growth factor binding-independent biologic activity in the growing skeleton. J Biol Chem. 2011 Apr 22; 286(16):14670-80.
    View in: PubMed
  43. Dufour AB, Roberts B, Broe KE, Kiel DP, Bouxsein ML, Hannan MT. The factor-of-risk biomechanical approach predicts hip fracture in men and women: the Framingham Study. Osteoporos Int. 2012 Feb; 23(2):513-20.
    View in: PubMed
  44. Kim YM, Demissie S, Eisenberg R, Samelson EJ, Kiel DP, Bouxsein ML. Intra-and inter-reader reliability of semi-automated quantitative morphometry measurements and vertebral fracture assessment using lateral scout views from computed tomography. Osteoporos Int. 2011 Oct; 22(10):2677-88.
    View in: PubMed
  45. Christiansen BA, Bouxsein ML. Biomechanics of vertebral fractures and the vertebral fracture cascade. Curr Osteoporos Rep. 2010 Dec; 8(4):198-204.
    View in: PubMed
  46. Rizzoli R, Akesson K, Bouxsein M, Kanis JA, Napoli N, Papapoulos S, Reginster JY, Cooper C. Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report. Osteoporos Int. 2011 Feb; 22(2):373-90.
    View in: PubMed
  47. Wegrzyn J, Roux JP, Arlot ME, Boutroy S, Vilayphiou N, Guyen O, Delmas PD, Chapurlat R, Bouxsein ML. Role of trabecular microarchitecture and its heterogeneity parameters in the mechanical behavior of ex vivo human L3 vertebrae. J Bone Miner Res. 2010 Nov; 25(11):2324-31.
    View in: PubMed
  48. Follet H, Viguet-Carrin S, Burt-Pichat B, Dépalle B, Bala Y, Gineyts E, Munoz F, Arlot M, Boivin G, Chapurlat RD, Delmas PD, Bouxsein ML. Effects of preexisting microdamage, collagen cross-links, degree of mineralization, age, and architecture on compressive mechanical properties of elderly human vertebral trabecular bone. J Orthop Res. 2011 Apr; 29(4):481-8.
    View in: PubMed
  49. Jones MD, Liu JC, Barthel TK, Hussain S, Lovria E, Cheng D, Schoonmaker JA, Mulay S, Ayers DC, Bouxsein ML, Stein GS, Mukherjee S, Lian JB. A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes. Clin Cancer Res. 2010 Oct 15; 16(20):4978-89.
    View in: PubMed
  50. Devlin MJ, Cloutier AM, Thomas NA, Panus DA, Lotinun S, Pinz I, Baron R, Rosen CJ, Bouxsein ML. Caloric restriction leads to high marrow adiposity and low bone mass in growing mice. J Bone Miner Res. 2010 Sep; 25(9):2078-88.
    View in: PubMed
  51. Iyer S, Christiansen BA, Roberts BJ, Valentine MJ, Manoharan RK, Bouxsein ML. A biomechanical model for estimating loads on thoracic and lumbar vertebrae. Clin Biomech (Bristol, Avon). 2010 Nov; 25(9):853-8.
    View in: PubMed
  52. Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ, Müller R. Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Miner Res. 2010 Jul; 25(7):1468-86.
    View in: PubMed
  53. Craig ZR, Marion SL, Funk JL, Bouxsein ML, Hoyer PB. Retaining Residual Ovarian Tissue following Ovarian Failure Has Limited Influence on Bone Loss in Aged Mice. J Osteoporos. 2010; 2010.
    View in: PubMed
  54. Kiel DP, Hannan MT, Barton BA, Bouxsein ML, Lang TF, Brown KM, Shane E, Magaziner J, Zimmerman S, Rubin CT. Insights from the conduct of a device trial in older persons: low magnitude mechanical stimulation for musculoskeletal health. Clin Trials. 2010 Aug; 7(4):354-67.
    View in: PubMed
  55. Chantry AD, Heath D, Mulivor AW, Pearsall S, Baud'huin M, Coulton L, Evans H, Abdul N, Werner ED, Bouxsein ML, Key ML, Seehra J, Arnett TR, Vanderkerken K, Croucher P. Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo. J Bone Miner Res. 2010 Dec; 25(12):2633-46.
    View in: PubMed
  56. Wagner EB, Granzella NP, Saito H, Newman DJ, Young LR, Bouxsein ML. Partial weight suspension: a novel murine model for investigating adaptation to reduced musculoskeletal loading. J Appl Physiol. 2010 Aug; 109(2):350-7.
    View in: PubMed
  57. Guo J, Liu M, Yang D, Bouxsein ML, Thomas CC, Schipani E, Bringhurst FR, Kronenberg HM. Phospholipase C signaling via the parathyroid hormone (PTH)/PTH-related peptide receptor is essential for normal bone responses to PTH. Endocrinology. 2010 Aug; 151(8):3502-13.
    View in: PubMed
  58. Samelson EJ, Christiansen BA, Demissie S, Broe KE, Zhou Y, Meng CA, Yu W, Cheng X, O'Donnell CJ, Hoffmann U, Genant HK, Kiel DP, Bouxsein ML. Reliability of vertebral fracture assessment using multidetector CT lateral scout views: the Framingham Osteoporosis Study. Osteoporos Int. 2011 Apr; 22(4):1123-31.
    View in: PubMed
  59. Guo J, Liu M, Yang D, Bouxsein ML, Saito H, Galvin RJ, Kuhstoss SA, Thomas CC, Schipani E, Baron R, Bringhurst FR, Kronenberg HM. Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation. Cell Metab. 2010 Feb 3; 11(2):161-71.
    View in: PubMed
  60. Fritton JC, Emerton KB, Sun H, Kawashima Y, Mejia W, Wu Y, Rosen CJ, Panus D, Bouxsein M, Majeska RJ, Schaffler MB, Yakar S. Growth hormone protects against ovariectomy-induced bone loss in states of low circulating insulin-like growth factor (IGF-1). J Bone Miner Res. 2010 Feb; 25(2):235-46.
    View in: PubMed
  61. Roux JP, Wegrzyn J, Arlot ME, Guyen O, Delmas PD, Chapurlat R, Bouxsein ML. Contribution of trabecular and cortical components to biomechanical behavior of human vertebrae: an ex vivo study. J Bone Miner Res. 2010 Feb; 25(2):356-61.
    View in: PubMed
  62. Seeherman HJ, Li XJ, Bouxsein ML, Wozney JM. rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model. J Bone Joint Surg Am. 2010 Feb; 92(2):411-26.
    View in: PubMed
  63. Lotinun S, Pearsall RS, Davies MV, Marvell TH, Monnell TE, Ucran J, Fajardo RJ, Kumar R, Underwood KW, Seehra J, Bouxsein ML, Baron R. A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeys. Bone. 2010 Apr; 46(4):1082-8.
    View in: PubMed
  64. Borah B, Dufresne T, Nurre J, Phipps R, Chmielewski P, Wagner L, Lundy M, Bouxsein M, Zebaze R, Seeman E. Risedronate reduces intracortical porosity in women with osteoporosis. J Bone Miner Res. 2010 Jan; 25(1):41-7.
    View in: PubMed
  65. Shomento SH, Wan C, Cao X, Faugere MC, Bouxsein ML, Clemens TL, Riddle RC. Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development. J Cell Biochem. 2010 Jan 1; 109(1):196-204.
    View in: PubMed
  66. Bouxsein ML, Seeman E. Quantifying the material and structural determinants of bone strength. Best Pract Res Clin Rheumatol. 2009 Dec; 23(6):741-53.
    View in: PubMed
  67. Roberts BJ, Thrall E, Muller JA, Bouxsein ML. Comparison of hip fracture risk prediction by femoral aBMD to experimentally measured factor of risk. Bone. 2010 Mar; 46(3):742-6.
    View in: PubMed
  68. Viguet-Carrin S, Follet H, Gineyts E, Roux JP, Munoz F, Chapurlat R, Delmas PD, Bouxsein ML. Association between collagen cross-links and trabecular microarchitecture properties of human vertebral bone. Bone. 2010 Feb; 46(2):342-7.
    View in: PubMed
  69. Ferrari SL, Bouxsein ML. Beta-arrestin-biased parathyroid hormone ligands: a new approach to the development of agents that stimulate bone formation. Sci Transl Med. 2009 Oct 7; 1(1):1ps1.
    View in: PubMed
  70. Fajardo RJ, Manoharan RK, Pearsall RS, Davies MV, Marvell T, Monnell TE, Ucran JA, Pearsall AE, Khanzode D, Kumar R, Underwood KW, Roberts B, Seehra J, Bouxsein ML. Treatment with a soluble receptor for activin improves bone mass and structure in the axial and appendicular skeleton of female cynomolgus macaques (Macaca fascicularis). Bone. 2010 Jan; 46(1):64-71.
    View in: PubMed
  71. Pozzi S, Vallet S, Mukherjee S, Cirstea D, Vaghela N, Santo L, Rosen E, Ikeda H, Okawa Y, Kiziltepe T, Schoonmaker J, Xie W, Hideshima T, Weller E, Bouxsein ML, Munshi NC, Anderson KC, Raje N. High-dose zoledronic acid impacts bone remodeling with effects on osteoblastic lineage and bone mechanical properties. Clin Cancer Res. 2009 Sep 15; 15(18):5829-39.
    View in: PubMed
  72. Sornay-Rendu E, Boutroy S, Munoz F, Bouxsein ML. Cortical and trabecular architecture are altered in postmenopausal women with fractures. Osteoporos Int. 2009 Aug; 20(8):1291-7.
    View in: PubMed
  73. Yakar S, Canalis E, Sun H, Mejia W, Kawashima Y, Nasser P, Courtland HW, Williams V, Bouxsein M, Rosen C, Jepsen KJ. Serum IGF-1 determines skeletal strength by regulating subperiosteal expansion and trait interactions. J Bone Miner Res. 2009 Aug; 24(8):1481-92.
    View in: PubMed
  74. Kirmani S, Christen D, van Lenthe GH, Fischer PR, Bouxsein ML, McCready LK, Melton LJ, Riggs BL, Amin S, Müller R, Khosla S. Bone structure at the distal radius during adolescent growth. J Bone Miner Res. 2009 Jun; 24(6):1033-42.
    View in: PubMed
  75. Bouxsein ML, Chen P, Glass EV, Kallmes DF, Delmas PD, Mitlak BH. Teriparatide and raloxifene reduce the risk of new adjacent vertebral fractures in postmenopausal women with osteoporosis. Results from two randomized controlled trials. J Bone Joint Surg Am. 2009 Jun; 91(6):1329-38.
    View in: PubMed
  76. Pierroz DD, Rufo A, Bianchi EN, Glatt V, Capulli M, Rucci N, Cavat F, Rizzoli R, Teti A, Bouxsein ML, Ferrari SL. Beta-Arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice. J Bone Miner Res. 2009 May; 24(5):775-84.
    View in: PubMed
  77. Rozental TD, Vazquez MA, Chacko AT, Ayogu N, Bouxsein ML. Comparison of radiographic fracture healing in the distal radius for patients on and off bisphosphonate therapy. J Hand Surg Am. 2009 Apr; 34(4):595-602.
    View in: PubMed
  78. Brouwers JE, Ruchelsman M, Rietbergen Bv, Bouxsein ML. Determination of rat vertebral bone compressive fatigue properties in untreated intact rats and zoledronic-acid-treated, ovariectomized rats. Osteoporos Int. 2009 Aug; 20(8):1377-84.
    View in: PubMed
  79. Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med. 2008 Dec; 14(12):1363-9.
    View in: PubMed
  80. Nielson CM, Bouxsein ML, Freitas SS, Ensrud KE, Orwoll ES. Trochanteric soft tissue thickness and hip fracture in older men. J Clin Endocrinol Metab. 2009 Feb; 94(2):491-6.
    View in: PubMed
  81. Yakar S, Rosen CJ, Bouxsein ML, Sun H, Mejia W, Kawashima Y, Wu Y, Emerton K, Williams V, Jepsen K, Schaffler MB, Majeska RJ, Gavrilova O, Gutierrez M, Hwang D, Pennisi P, Frystyk J, Boisclair Y, Pintar J, Jasper H, Domene H, Cohen P, Clemmons D, LeRoith D. Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J. 2009 Mar; 23(3):709-19.
    View in: PubMed
  82. Okazaki M, Ferrandon S, Vilardaga JP, Bouxsein ML, Potts JT, Gardella TJ. Prolonged signaling at the parathyroid hormone receptor by peptide ligands targeted to a specific receptor conformation. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16525-30.
    View in: PubMed
  83. Bouxsein ML, Delmas PD. Vertebral fracture assessment using standard bone densitometry equipment predicts incident fractures in women. Nat Clin Pract Endocrinol Metab. 2008 Dec; 4(12):652-3.
    View in: PubMed
  84. Keaveny TM, Bouxsein ML. Theoretical implications of the biomechanical fracture threshold. J Bone Miner Res. 2008 Oct; 23(10):1541-7.
    View in: PubMed
  85. Arlot ME, Burt-Pichat B, Roux JP, Vashishth D, Bouxsein ML, Delmas PD. Microarchitecture influences microdamage accumulation in human vertebral trabecular bone. J Bone Miner Res. 2008 Oct; 23(10):1613-8.
    View in: PubMed
  86. Bouxsein ML, Devlin MJ, Glatt V, Dhillon H, Pierroz DD, Ferrari SL. Mice lacking beta-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectomy. Endocrinology. 2009 Jan; 150(1):144-52.
    View in: PubMed
  87. Melton LJ, Riggs BL, Leibson CL, Achenbach SJ, Camp JJ, Bouxsein ML, Atkinson EJ, Robb RA, Khosla S. A bone structural basis for fracture risk in diabetes. J Clin Endocrinol Metab. 2008 Dec; 93(12):4804-9.
    View in: PubMed
  88. Fajardo RJ, Cory E, Patel ND, Nazarian A, Laib A, Manoharan RK, Schmitz JE, DeSilva JM, MacLatchy LM, Snyder BD, Bouxsein ML. Specimen size and porosity can introduce error into microCT-based tissue mineral density measurements. Bone. 2009 Jan; 44(1):176-84.
    View in: PubMed
  89. Ackert-Bicknell CL, Demissie S, Marín de Evsikova C, Hsu YH, DeMambro VE, Karasik D, Cupples LA, Ordovas JM, Tucker KL, Cho K, Canalis E, Paigen B, Churchill GA, Forejt J, Beamer WG, Ferrari S, Bouxsein ML, Kiel DP, Rosen CJ. PPARG by dietary fat interaction influences bone mass in mice and humans. J Bone Miner Res. 2008 Sep; 23(9):1398-408.
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  90. Brouwers JE, van Rietbergen B, Bouxsein ML. Influence of early and late zoledronic acid administration on vertebral structure and strength in ovariectomized rats. Calcif Tissue Int. 2008 Sep; 83(3):186-91.
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  91. O'Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling AG, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC, Bellido T. Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS One. 2008; 3(8):e2942.
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  92. Berman SD, Calo E, Landman AS, Danielian PS, Miller ES, West JC, Fonhoue BD, Caron A, Bronson R, Bouxsein ML, Mukherjee S, Lees JA. Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11851-6.
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  93. Wright LE, Christian PJ, Rivera Z, Van Alstine WG, Funk JL, Bouxsein ML, Hoyer PB. Comparison of skeletal effects of ovariectomy versus chemically induced ovarian failure in mice. J Bone Miner Res. 2008 Aug; 23(8):1296-303.
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  94. Black DM, Bouxsein ML, Marshall LM, Cummings SR, Lang TF, Cauley JA, Ensrud KE, Nielson CM, Orwoll ES. Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT. J Bone Miner Res. 2008 Aug; 23(8):1326-33.
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  95. Davey RA, Turner AG, McManus JF, Chiu WS, Tjahyono F, Moore AJ, Atkins GJ, Anderson PH, Ma C, Glatt V, MacLean HE, Vincent C, Bouxsein M, Morris HA, Findlay DM, Zajac JD. Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice. J Bone Miner Res. 2008 Aug; 23(8):1182-93.
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  96. Bouxsein ML, Delmas PD. Considerations for development of surrogate endpoints for antifracture efficacy of new treatments in osteoporosis: a perspective. J Bone Miner Res. 2008 Aug; 23(8):1155-67.
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  97. Shimada M, Greer PA, McMahon AP, Bouxsein ML, Schipani E. In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation. J Biol Chem. 2008 Jul 25; 283(30):21002-10.
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  98. Pearsall RS, Canalis E, Cornwall-Brady M, Underwood KW, Haigis B, Ucran J, Kumar R, Pobre E, Grinberg A, Werner ED, Glatt V, Stadmeyer L, Smith D, Seehra J, Bouxsein ML. A soluble activin type IIA receptor induces bone formation and improves skeletal integrity. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):7082-7.
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  99. Rozental TD, Makhni EC, Day CS, Bouxsein ML. Improving evaluation and treatment for osteoporosis following distal radial fractures. A prospective randomized intervention. J Bone Joint Surg Am. 2008 May; 90(5):953-61.
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  101. Black DM, Bouxsein ML, Palermo L, McGowan JA, Newitt DC, Rosen E, Majumdar S, Rosen CJ. Randomized trial of once-weekly parathyroid hormone (1-84) on bone mineral density and remodeling. J Clin Endocrinol Metab. 2008 Jun; 93(6):2166-72.
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  102. Boutroy S, Van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD. Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Miner Res. 2008 Mar; 23(3):392-9.
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  103. DeMambro VE, Clemmons DR, Horton LG, Bouxsein ML, Wood TL, Beamer WG, Canalis E, Rosen CJ. Gender-specific changes in bone turnover and skeletal architecture in igfbp-2-null mice. Endocrinology. 2008 May; 149(5):2051-61.
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  104. McManus JF, Davey RA, Maclean HE, Doust EA, Chiu WS, Sims NA, Bouxsein ML, Glatt V, Zajac JD, Danks JA. Intermittent Fugu parathyroid hormone 1 (1-34) is an anabolic bone agent in young male rats and osteopenic ovariectomized rats. Bone. 2008 Jun; 42(6):1164-74.
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  105. Mukherjee S, Raje N, Schoonmaker JA, Liu JC, Hideshima T, Wein MN, Jones DC, Vallet S, Bouxsein ML, Pozzi S, Chhetri S, Seo YD, Aronson JP, Patel C, Fulciniti M, Purton LE, Glimcher LH, Lian JB, Stein G, Anderson KC, Scadden DT. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest. 2008 Feb; 118(2):491-504.
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  106. Engelke K, Adams JE, Armbrecht G, Augat P, Bogado CE, Bouxsein ML, Felsenberg D, Ito M, Prevrhal S, Hans DB, Lewiecki EM. Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions. J Clin Densitom. 2008 Jan-Mar; 11(1):123-62.
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  107. Melton LJ, Riggs BL, Keaveny TM, Achenbach SJ, Hoffmann PF, Camp JJ, Rouleau PA, Bouxsein ML, Amin S, Atkinson EJ, Robb RA, Khosla S. Structural determinants of vertebral fracture risk. J Bone Miner Res. 2007 Dec; 22(12):1885-92.
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  108. Kostenuik PJ, Ferrari S, Pierroz D, Bouxsein M, Morony S, Warmington KS, Adamu S, Geng Z, Grisanti M, Shalhoub V, Martin S, Biddlecome G, Shimamoto G, Boone T, Shen V, Lacey D. Infrequent delivery of a long-acting PTH-Fc fusion protein has potent anabolic effects on cortical and cancellous bone. J Bone Miner Res. 2007 Oct; 22(10):1534-47.
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  109. Betz VM, Betz OB, Glatt V, Gerstenfeld LC, Einhorn TA, Bouxsein ML, Vrahas MS, Evans CH. Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector dose. Hum Gene Ther. 2007 Oct; 18(10):907-15.
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  110. Viguet-Carrin S, Farlay D, Bala Y, Munoz F, Bouxsein ML, Delmas PD. An in vitro model to test the contribution of advanced glycation end products to bone biomechanical properties. Bone. 2008 Jan; 42(1):139-49.
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  111. Melton LJ, Riggs BL, van Lenthe GH, Achenbach SJ, Müller R, Bouxsein ML, Amin S, Atkinson EJ, Khosla S. Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women. J Bone Miner Res. 2007 Sep; 22(9):1442-8.
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  112. Tsiridis E, Morgan EF, Bancroft JM, Song M, Kain M, Gerstenfeld L, Einhorn TA, Bouxsein ML, Tornetta P. Effects of OP-1 and PTH in a new experimental model for the study of metaphyseal bone healing. J Orthop Res. 2007 Sep; 25(9):1193-203.
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  113. Glatt V, Canalis E, Stadmeyer L, Bouxsein ML. Age-related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res. 2007 Aug; 22(8):1197-207.
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  114. Bouxsein ML, Szulc P, Munoz F, Thrall E, Sornay-Rendu E, Delmas PD. Contribution of trochanteric soft tissues to fall force estimates, the factor of risk, and prediction of hip fracture risk. J Bone Miner Res. 2007 Jun; 22(6):825-31.
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  115. Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest. 2007 Jun; 117(6):1616-26.
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  116. Betz OB, Betz VM, Nazarian A, Egermann M, Gerstenfeld LC, Einhorn TA, Vrahas MS, Bouxsein ML, Evans CH. Delayed administration of adenoviral BMP-2 vector improves the formation of bone in osseous defects. Gene Ther. 2007 Jul; 14(13):1039-44.
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  117. Notini AJ, McManus JF, Moore A, Bouxsein M, Jimenez M, Chiu WS, Glatt V, Kream BE, Handelsman DJ, Morris HA, Zajac JD, Davey RA. Osteoblast deletion of exon 3 of the androgen receptor gene results in trabecular bone loss in adult male mice. J Bone Miner Res. 2007 Mar; 22(3):347-56.
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  118. Yang D, Singh R, Divieti P, Guo J, Bouxsein ML, Bringhurst FR. Contributions of parathyroid hormone (PTH)/PTH-related peptide receptor signaling pathways to the anabolic effect of PTH on bone. Bone. 2007 Jun; 40(6):1453-61.
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  119. Liu X, Bruxvoort KJ, Zylstra CR, Liu J, Cichowski R, Faugere MC, Bouxsein ML, Wan C, Williams BO, Clemens TL. Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2259-64.
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  120. Hsu YH, Xu X, Terwedow HA, Niu T, Hong X, Wu D, Wang L, Brain JD, Bouxsein ML, Cummings SR, Rosen CJ, Xu X. Large-scale genome-wide linkage analysis for loci linked to BMD at different skeletal sites in extreme selected sibships. J Bone Miner Res. 2007 Feb; 22(2):184-94.
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  121. Bouxsein ML, Melton LJ, Riggs BL, Muller J, Atkinson EJ, Oberg AL, Robb RA, Camp JJ, Rouleau PA, McCollough CH, Khosla S. Age- and sex-specific differences in the factor of risk for vertebral fracture: a population-based study using QCT. J Bone Miner Res. 2006 Sep; 21(9):1475-82.
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  122. Viguet-Carrin S, Roux JP, Arlot ME, Merabet Z, Leeming DJ, Byrjalsen I, Delmas PD, Bouxsein ML. Contribution of the advanced glycation end product pentosidine and of maturation of type I collagen to compressive biomechanical properties of human lumbar vertebrae. Bone. 2006 Nov; 39(5):1073-9.
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  123. Zalloua PA, Hsu YH, Terwedow H, Zang T, Wu D, Tang G, Li Z, Hong X, Azar ST, Wang B, Bouxsein ML, Brain J, Cummings SR, Rosen CJ, Xu X. Impact of seafood and fruit consumption on bone mineral density. Maturitas. 2007 Jan 20; 56(1):1-11.
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  124. Bouxsein ML, Karasik D. Bone geometry and skeletal fragility. Curr Osteoporos Rep. 2006 Jun; 4(2):49-56.
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  125. Yakar S, Bouxsein ML, Canalis E, Sun H, Glatt V, Gundberg C, Cohen P, Hwang D, Boisclair Y, Leroith D, Rosen CJ. The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. J Endocrinol. 2006 May; 189(2):289-99.
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  126. Thomas T, Feron JM, Delmas PD, Kaufman J, Tosi L, Cummings S, Lane J, Johnell O, Bouxsein ML. [Optimal management of patients with stress fractures and the role of the orthopedic surgeon in reducing the risk of new fractures]. Rev Chir Orthop Reparatrice Appar Mot. 2006 Apr; 92(2):165-74.
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  127. Pierroz DD, Bouxsein ML, Rizzoli R, Ferrari SL. Combined treatment with a beta-blocker and intermittent PTH improves bone mass and microarchitecture in ovariectomized mice. Bone. 2006 Aug; 39(2):260-7.
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  128. Betz OB, Betz VM, Nazarian A, Pilapil CG, Vrahas MS, Bouxsein ML, Gerstenfeld LC, Einhorn TA, Evans CH. Direct percutaneous gene delivery to enhance healing of segmental bone defects. J Bone Joint Surg Am. 2006 Feb; 88(2):355-65.
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  129. Hsu YH, Venners SA, Terwedow HA, Feng Y, Niu T, Li Z, Laird N, Brain JD, Cummings SR, Bouxsein ML, Rosen CJ, Xu X. Relation of body composition, fat mass, and serum lipids to osteoporotic fractures and bone mineral density in Chinese men and women. Am J Clin Nutr. 2006 Jan; 83(1):146-54.
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  130. Seeherman H, Li R, Bouxsein M, Kim H, Li XJ, Smith-Adaline EA, Aiolova M, Wozney JM. rhBMP-2/calcium phosphate matrix accelerates osteotomy-site healing in a nonhuman primate model at multiple treatment times and concentrations. J Bone Joint Surg Am. 2006 Jan; 88(1):144-60.
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  131. Rosen CJ, Bouxsein ML. Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol. 2006 Jan; 2(1):35-43.
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  132. Bouxsein ML. Determinants of skeletal fragility. Best Pract Res Clin Rheumatol. 2005 Dec; 19(6):897-911.
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  133. Garnero P, Borel O, Gineyts E, Duboeuf F, Solberg H, Bouxsein ML, Christiansen C, Delmas PD. Extracellular post-translational modifications of collagen are major determinants of biomechanical properties of fetal bovine cortical bone. Bone. 2006 Mar; 38(3):300-9.
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  134. Riggs BL, Melton LJ, Robb RA, Camp JJ, Atkinson EJ, Oberg AL, Rouleau PA, McCollough CH, Khosla S, Bouxsein ML. Population-based analysis of the relationship of whole bone strength indices and fall-related loads to age- and sex-specific patterns of hip and wrist fractures. J Bone Miner Res. 2006 Feb; 21(2):315-23.
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  135. Bouxsein ML, Fajardo RJ. Cortical stability of the femoral neck and hip fracture risk. Lancet. 2005 Oct 29-Nov 4; 366(9496):1523-4; author reply 1524-5.
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  136. Boutroy S, Bouxsein ML, Munoz F, Delmas PD. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab. 2005 Dec; 90(12):6508-15.
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  137. Feng Y, Hsu YH, Terwedow H, Chen Cz, Xu X, Niu T, Zang T, Wu D, Tang G, Li Z, Hong X, Wang B, Brain JD, Cummings SR, Rosen C, Bouxsein ML, Xu X. Familial aggregation of bone mineral density and bone mineral content in a Chinese population. Osteoporos Int. 2005 Dec; 16(12):1917-23.
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  138. Holmen SL, Zylstra CR, Mukherjee A, Sigler RE, Faugere MC, Bouxsein ML, Deng L, Clemens TL, Williams BO. Essential role of beta-catenin in postnatal bone acquisition. J Biol Chem. 2005 Jun 3; 280(22):21162-8.
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  139. Bouxsein ML, Myers KS, Shultz KL, Donahue LR, Rosen CJ, Beamer WG. Ovariectomy-induced bone loss varies among inbred strains of mice. J Bone Miner Res. 2005 Jul; 20(7):1085-92.
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  140. Ferrari SL, Pierroz DD, Glatt V, Goddard DS, Bianchi EN, Lin FT, Manen D, Bouxsein ML. Bone response to intermittent parathyroid hormone is altered in mice null for {beta}-Arrestin2. Endocrinology. 2005 Apr; 146(4):1854-62.
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  141. Knopp E, Troiano N, Bouxsein M, Sun BH, Lostritto K, Gundberg C, Dziura J, Insogna K. The effect of aging on the skeletal response to intermittent treatment with parathyroid hormone. Endocrinology. 2005 Apr; 146(4):1983-90.
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  142. Bouxsein ML, Pierroz DD, Glatt V, Goddard DS, Cavat F, Rizzoli R, Ferrari SL. beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice. J Bone Miner Res. 2005 Apr; 20(4):635-43.
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  143. Bouxsein ML. Non-invasive measurements of bone strength: promise and peril. J Musculoskelet Neuronal Interact. 2004 Dec; 4(4):404-5.
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  144. Rosen CJ, Ackert-Bicknell C, Beamer WG, Nelson T, Adamo M, Cohen P, Bouxsein ML, Horowitz MC. Allelic differences in a quantitative trait locus affecting insulin-like growth factor-I impact skeletal acquisition and body composition. Pediatr Nephrol. 2005 Mar; 20(3):255-60.
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  145. Rosen CJ, Ackert-Bicknell CL, Adamo ML, Shultz KL, Rubin J, Donahue LR, Horton LG, Delahunty KM, Beamer WG, Sipos J, Clemmons D, Nelson T, Bouxsein ML, Horowitz M. Congenic mice with low serum IGF-I have increased body fat, reduced bone mineral density, and an altered osteoblast differentiation program. Bone. 2004 Nov; 35(5):1046-58.
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  146. Bouxsein ML, Kaufman J, Tosi L, Cummings S, Lane J, Johnell O. Recommendations for optimal care of the fragility fracture patient to reduce the risk of future fracture. J Am Acad Orthop Surg. 2004 Nov-Dec; 12(6):385-95.
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  147. Bertone AL, Pittman DD, Bouxsein ML, Li J, Clancy B, Seeherman HJ. Adenoviral-mediated transfer of human BMP-6 gene accelerates healing in a rabbit ulnar osteotomy model. J Orthop Res. 2004 Nov; 22(6):1261-70.
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  148. Riggs BL, Melton Iii LJ, Robb RA, Camp JJ, Atkinson EJ, Peterson JM, Rouleau PA, McCollough CH, Bouxsein ML, Khosla S. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res. 2004 Dec; 19(12):1945-54.
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  149. Holmen SL, Giambernardi TA, Zylstra CR, Buckner-Berghuis BD, Resau JH, Hess JF, Glatt V, Bouxsein ML, Ai M, Warman ML, Williams BO. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res. 2004 Dec; 19(12):2033-40.
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  150. Seeherman HJ, Bouxsein M, Kim H, Li R, Li XJ, Aiolova M, Wozney JM. Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a nonhuman primate model. J Bone Joint Surg Am. 2004 Sep; 86-A(9):1961-72.
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  151. Johnston JD, Small CF, Bouxsein ML, Pichora DR. Mechanical properties of the scapholunate ligament correlate with bone mineral density measurements of the hand. J Orthop Res. 2004 Jul; 22(4):867-71.
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  152. Yakar S, Setser J, Zhao H, Stannard B, Haluzik M, Glatt V, Bouxsein ML, Kopchick JJ, LeRoith D. Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice. J Clin Invest. 2004 Jan; 113(1):96-105.
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  153. Kacena MA, Shivdasani RA, Wilson K, Xi Y, Troiano N, Nazarian A, Gundberg CM, Bouxsein ML, Lorenzo JA, Horowitz MC. Megakaryocyte-osteoblast interaction revealed in mice deficient in transcription factors GATA-1 and NF-E2. J Bone Miner Res. 2004 Apr; 19(4):652-60.
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  154. Bouxsein ML, Uchiyama T, Rosen CJ, Shultz KL, Donahue LR, Turner CH, Sen S, Churchill GA, Müller R, Beamer WG. Mapping quantitative trait loci for vertebral trabecular bone volume fraction and microarchitecture in mice. J Bone Miner Res. 2004 Apr; 19(4):587-99.
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  155. Tingart MJ, Bouxsein ML, Zurakowski D, Warner JP, Apreleva M. Three-dimensional distribution of bone density in the proximal humerus. Calcif Tissue Int. 2003 Dec; 73(6):531-6.
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  156. Li RH, Bouxsein ML, Blake CA, D'Augusta D, Kim H, Li XJ, Wozney JM, Seeherman HJ. rhBMP-2 injected in a calcium phosphate paste (alpha-BSM) accelerates healing in the rabbit ulnar osteotomy model. J Orthop Res. 2003 Nov; 21(6):997-1004.
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  157. Black DM, Greenspan SL, Ensrud KE, Palermo L, McGowan JA, Lang TF, Garnero P, Bouxsein ML, Bilezikian JP, Rosen CJ. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med. 2003 Sep 25; 349(13):1207-15.
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  158. Turner CH, Sun Q, Schriefer J, Pitner N, Price R, Bouxsein ML, Rosen CJ, Donahue LR, Shultz KL, Beamer WG. Congenic mice reveal sex-specific genetic regulation of femoral structure and strength. Calcif Tissue Int. 2003 Sep; 73(3):297-303.
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  159. Bouxsein ML. Bone quality: where do we go from here? Osteoporos Int. 2003 Sep; 14 Suppl 5:S118-27.
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  160. Einhorn TA, Majeska RJ, Mohaideen A, Kagel EM, Bouxsein ML, Turek TJ, Wozney JM. A single percutaneous injection of recombinant human bone morphogenetic protein-2 accelerates fracture repair. J Bone Joint Surg Am. 2003 Aug; 85-A(8):1425-35.
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  161. Babij P, Zhao W, Small C, Kharode Y, Yaworsky PJ, Bouxsein ML, Reddy PS, Bodine PV, Robinson JA, Bhat B, Marzolf J, Moran RA, Bex F. High bone mass in mice expressing a mutant LRP5 gene. J Bone Miner Res. 2003 Jun; 18(6):960-74.
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  162. Muller ME, Webber CE, Bouxsein ML. Predicting the failure load of the distal radius. Osteoporos Int. 2003 Jun; 14(4):345-52.
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  163. Shultz KL, Donahue LR, Bouxsein ML, Baylink DJ, Rosen CJ, Beamer WG. Congenic strains of mice for verification and genetic decomposition of quantitative trait loci for femoral bone mineral density. J Bone Miner Res. 2003 Feb; 18(2):175-85.
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  164. Bonner FJ, Sinaki M, Grabois M, Shipp KM, Lane JM, Lindsay R, Gold DT, Cosman F, Bouxsein ML, Weinstein JN, Gallagher RM, Melton LJ, Salcido RS, Gordon SL. Health professional's guide to rehabilitation of the patient with osteoporosis. Osteoporos Int. 2003; 14 Suppl 2:S1-22.
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  165. Bouxsein ML. Mechanisms of osteoporosis therapy: a bone strength perspective. Clin Cornerstone. 2003; Suppl 2:S13-21.
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  166. Nicholson PH, Bouxsein ML. Effect of temperature on ultrasonic properties of the calcaneus in situ. Osteoporos Int. 2002 Nov; 13(11):888-92.
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  167. Zhang M, Xuan S, Bouxsein ML, von Stechow D, Akeno N, Faugere MC, Malluche H, Zhao G, Rosen CJ, Efstratiadis A, Clemens TL. Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem. 2002 Nov 15; 277(46):44005-12.
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  168. Li G, Bouxsein ML, Luppen C, Li XJ, Wood M, Seeherman HJ, Wozney JM, Simpson H. Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis. J Orthop Res. 2002 Jul; 20(4):779-88.
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  169. Bouxsein ML, Palermo L, Yeung C, Black DM. Digital X-ray radiogrammetry predicts hip, wrist and vertebral fracture risk in elderly women: a prospective analysis from the study of osteoporotic fractures. Osteoporos Int. 2002 May; 13(5):358-65.
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  170. Bouxsein ML, Rosen CJ, Turner CH, Ackert CL, Shultz KL, Donahue LR, Churchill G, Adamo ML, Powell DR, Turner RT, Muller R, Beamer WG. Generation of a new congenic mouse strain to test the relationships among serum insulin-like growth factor I, bone mineral density, and skeletal morphology in vivo. J Bone Miner Res. 2002 Apr; 17(4):570-9.
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  171. Nicholson PH, Bouxsein ML. Bone marrow influences quantitative ultrasound measurements in human cancellous bone. Ultrasound Med Biol. 2002 Mar; 28(3):369-75.
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  172. Luppen CA, Blake CA, Ammirati KM, Stevens ML, Seeherman HJ, Wozney JM, Bouxsein ML. Recombinant human bone morphogenetic protein-2 enhances osteotomy healing in glucocorticoid-treated rabbits. J Bone Miner Res. 2002 Feb; 17(2):301-10.
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  173. Bouxsein ML, Turek TJ, Blake CA, D'Augusta D, Li X, Stevens M, Seeherman HJ, Wozney JM. Recombinant human bone morphogenetic protein-2 accelerates healing in a rabbit ulnar osteotomy model. J Bone Joint Surg Am. 2001 Aug; 83-A(8):1219-30.
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  174. Nelson DA, Bouxsein ML. Exercise maintains bone mass, but do people maintain exercise? J Bone Miner Res. 2001 Feb; 16(2):202-5.
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  175. Turner CH, Hsieh YF, Müller R, Bouxsein ML, Rosen CJ, McCrann ME, Donahue LR, Beamer WG. Variation in bone biomechanical properties, microstructure, and density in BXH recombinant inbred mice. J Bone Miner Res. 2001 Feb; 16(2):206-13.
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  176. Nicholson PH, Bouxsein ML. Quantitative ultrasound does not reflect mechanically induced damage in human cancellous bone. J Bone Miner Res. 2000 Dec; 15(12):2467-72.
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  177. Turner CH, Hsieh YF, Müller R, Bouxsein ML, Baylink DJ, Rosen CJ, Grynpas MD, Donahue LR, Beamer WG. Genetic regulation of cortical and trabecular bone strength and microstructure in inbred strains of mice. J Bone Miner Res. 2000 Jun; 15(6):1126-31.
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  178. McLean RR, Hannan MT, Epstein BE, Bouxsein ML, Cupples LA, Murabito J, Kiel DP. Elderly cohort study subjects unable to return for follow-up have lower bone mass than those who can return. Am J Epidemiol. 2000 Apr 1; 151(7):689-92.
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  179. Nicholson PH, Strelitzki R, Cleveland RO, Bouxsein ML. Scattering of ultrasound in cancellous bone: predictions from a theoretical model. J Biomech. 2000 Apr; 33(4):503-6.
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  180. Oden ZM, Selvitelli DM, Bouxsein ML. Effect of local density changes on the failure load of the proximal femur. J Orthop Res. 1999 Sep; 17(5):661-7.
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  181. Bouxsein ML, Coan BS, Lee SC. Prediction of the strength of the elderly proximal femur by bone mineral density and quantitative ultrasound measurements of the heel and tibia. Bone. 1999 Jul; 25(1):49-54.
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  182. Michaeli DA, Mirshahi A, Singer J, Rapa FG, Plass DB, Bouxsein ML. A new X-ray based osteoporosis screening tool provides accurate and precise assessment of phalanx bone mineral content. J Clin Densitom. 1999; 2(1):23-30.
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  183. Bouxsein ML, Parker RA, Greenspan SL. Forearm bone mineral densitometry cannot be used to monitor response to alendronate therapy in postmenopausal women. Osteoporos Int. 1999; 10(6):505-9.
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  184. Greenspan SL, Bouxsein ML, Melton ME, Kolodny AH, Clair JH, Delucca PT, Stek M, Faulkner KG, Orwoll ES. Precision and discriminatory ability of calcaneal bone assessment technologies. J Bone Miner Res. 1997 Aug; 12(8):1303-13.
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  185. Lee SC, Coan BS, Bouxsein ML. Tibial ultrasound velocity measured in situ predicts the material properties of tibial cortical bone. Bone. 1997 Jul; 21(1):119-25.
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  186. Bouxsein ML, Radloff SE. Quantitative ultrasound of the calcaneus reflects the mechanical properties of calcaneal trabecular bone. J Bone Miner Res. 1997 May; 12(5):839-46.
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  187. Bouxsein ML, Michaeli DA, Plass DB, Schick DA, Melton ME. Precision and accuracy of computed digital absorptiometry for assessment of bone density of the hand. Osteoporos Int. 1997; 7(5):444-9.
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  188. Pinilla TP, Boardman KC, Bouxsein ML, Myers ER, Hayes WC. Impact direction from a fall influences the failure load of the proximal femur as much as age-related bone loss. Calcif Tissue Int. 1996 Apr; 58(4):231-5.
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  189. Moro M, Hecker AT, Bouxsein ML, Myers ER. Failure load of thoracic vertebrae correlates with lumbar bone mineral density measured by DXA. Calcif Tissue Int. 1995 Mar; 56(3):206-9.
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  190. Bouxsein ML, Courtney AC, Hayes WC. Ultrasound and densitometry of the calcaneus correlate with the failure loads of cadaveric femurs. Calcif Tissue Int. 1995 Feb; 56(2):99-103.
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  191. Bouxsein ML, Marcus R. Overview of exercise and bone mass. Rheum Dis Clin North Am. 1994 Aug; 20(3):787-802.
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  192. Bouxsein ML, Myburgh KH, van der Meulen MC, Lindenberger E, Marcus R. Age-related differences in cross-sectional geometry of the forearm bones in healthy women. Calcif Tissue Int. 1994 Feb; 54(2):113-8.
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  193. Snow-Harter C, Bouxsein ML, Lewis BT, Carter DR, Marcus R. Effects of resistance and endurance exercise on bone mineral status of young women: a randomized exercise intervention trial. J Bone Miner Res. 1992 Jul; 7(7):761-9.
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  194. Carter DR, Bouxsein ML, Marcus R. New approaches for interpreting projected bone densitometry data. J Bone Miner Res. 1992 Feb; 7(2):137-45.
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  195. Snow-Harter C, Bouxsein M, Lewis B, Charette S, Weinstein P, Marcus R. Muscle strength as a predictor of bone mineral density in young women. J Bone Miner Res. 1990 Jun; 5(6):589-95.
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