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Last Name
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Andrew Tan Chan, M.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Gastrointestinal Unit, GRJ-722
55 Fruit St
Boston MA 02114
Phone617/726-2862

 Mentoring 
 current student opportunities
Available: 07/01/11, Expires: 06/01/13

We are interested in lifestyle, medication, diet, and genetic risk factors for chronic gastrointestinal diseases, including colorectal cancer, gallstone disease, gastrointestinal bleeding, and inflammatory bowel diseases. My group uses epidemiological techniques to examine risk factors and genetic markers in relation to disease incidence in large prospective cohorts based at Harvard. Depending on the student's abilities, a student can assist with review of medical records, assembly of data bases, literature reviews, and statistical analyses.

 completed student projects
A prospective study of circulating macrophage inhibitory cytokine-1 (MIC-1) levels and risk of colorectal cancer
Summer, 06/11/12 - 08/16/12

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Das KK, Nishino HT, Chan AT. Treatment-associated acute myeloid leukemia in a patient with Crohn's disease on 6-mercaptopurine. Inflamm Bowel Dis. 2010 Sep; 16(9):1454-6.
    View in: PubMed
  2. Chan AT, Giovannucci EL. Primary prevention of colorectal cancer. Gastroenterology. 2010 Jun; 138(6):2029-2043.e10.
    View in: PubMed
  3. Chan AT. COX-2 expression in adenoma: an imperfect marker for chemoprevention. Gut. 2010 May; 59(5):568-9.
    View in: PubMed
  4. Baba Y, Nosho K, Shima K, Irahara N, Chan AT, Meyerhardt JA, Chung DC, Giovannucci EL, Fuchs CS, Ogino S. HIF1A overexpression is associated with poor prognosis in a cohort of 731 colorectal cancers. Am J Pathol. 2010 May; 176(5):2292-301.
    View in: PubMed
  5. Baba Y, Nosho K, Shima K, Goessling W, Chan AT, Ng K, Chan JA, Giovannucci EL, Fuchs CS, Ogino S. PTGER2 overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype. Cancer Epidemiol Biomarkers Prev. 2010 Mar; 19(3):822-31.
    View in: PubMed
  6. Meyerhardt JA, Giovannucci EL, Ogino S, Kirkner GJ, Chan AT, Willett W, Fuchs CS. Physical activity and male colorectal cancer survival. Arch Intern Med. 2009 Dec 14; 169(22):2102-8.
    View in: PubMed
  7. Meyerhardt JA, Ogino S, Kirkner GJ, Chan AT, Wolpin B, Ng K, Nosho K, Shima K, Giovannucci EL, Loda M, Fuchs CS. Interaction of molecular markers and physical activity on mortality in patients with colon cancer. Clin Cancer Res. 2009 Sep 15; 15(18):5931-6.
    View in: PubMed
  8. Ng K, Wolpin BM, Meyerhardt JA, Wu K, Chan AT, Hollis BW, Giovannucci EL, Stampfer MJ, Willett WC, Fuchs CS. Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer. Br J Cancer. 2009 Sep 15; 101(6):916-23.
    View in: PubMed
  9. Chan AT, Ogino S, Fuchs CS. Aspirin use and survival after diagnosis of colorectal cancer. JAMA. 2009 Aug 12; 302(6):649-58.
    View in: PubMed
  10. Ogino S, Nosho K, Baba Y, Kure S, Shima K, Irahara N, Toyoda S, Chen L, Kirkner GJ, Wolpin BM, Chan AT, Giovannucci EL, Fuchs CS. A cohort study of STMN1 expression in colorectal cancer: body mass index and prognosis. Am J Gastroenterol. 2009 Aug; 104(8):2047-56.
    View in: PubMed
  11. Jacobson BC, Chan AT, Giovannucci EL, Fuchs CS. Body mass index and Barrett's oesophagus in women. Gut. 2009 Nov; 58(11):1460-6.
    View in: PubMed
  12. Wolpin BM, Chan AT, Hartge P, Chanock SJ, Kraft P, Hunter DJ, Giovannucci EL, Fuchs CS. ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst. 2009 Mar 18; 101(6):424-31.
    View in: PubMed
  13. Ogino S, Nosho K, Kirkner GJ, Shima K, Irahara N, Kure S, Chan AT, Engelman JA, Kraft P, Cantley LC, Giovannucci EL, Fuchs CS. PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. J Clin Oncol. 2009 Mar 20; 27(9):1477-84.
    View in: PubMed
  14. Chan AT, Zauber AG, Hsu M, Breazna A, Hunter DJ, Rosenstein RB, Eagle CJ, Hawk ET, Bertagnolli MM. Cytochrome P450 2C9 variants influence response to celecoxib for prevention of colorectal adenoma. Gastroenterology. 2009 Jun; 136(7):2127-2136.e1.
    View in: PubMed
  15. Chan AT. Time for a change: Is the 10-year interval too long?. AGA Perspectives. 2009; 5-8.
  16. Ogino S, Kirkner GJ, Nosho K, Irahara N, Kure S, Shima K, Hazra A, Chan AT, Dehari R, Giovannucci EL, Fuchs CS. Cyclooxygenase-2 expression is an independent predictor of poor prognosis in colon cancer. Clin Cancer Res. 2008 Dec 15; 14(24):8221-7.
    View in: PubMed
  17. Wolpin BM, Meyerhardt JA, Chan AT, Ng K, Chan JA, Wu K, Pollak MN, Giovannucci EL, Fuchs CS. Insulin, the insulin-like growth factor axis, and mortality in patients with nonmetastatic colorectal cancer. J Clin Oncol. 2009 Jan 10; 27(2):176-85.
    View in: PubMed
  18. Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Chan AT, Schernhammer ES, Giovannucci EL, Fuchs CS. A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer. J Natl Cancer Inst. 2008 Dec 3; 100(23):1734-8.
    View in: PubMed
  19. Nosho K, Kawasaki T, Chan AT, Ohnishi M, Suemoto Y, Kirkner GJ, Fuchs CS, Ogino S. Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype. Histopathology. 2008 Nov; 53(5):588-98.
    View in: PubMed
  20. Ogino S, Nosho K, Meyerhardt JA, Kirkner GJ, Chan AT, Kawasaki T, Giovannucci EL, Loda M, Fuchs CS. Cohort study of fatty acid synthase expression and patient survival in colon cancer. J Clin Oncol. 2008 Dec 10; 26(35):5713-20.
    View in: PubMed
  21. Berndt SI, Potter JD, Hazra A, Yeager M, Thomas G, Makar KW, Welch R, Cross AJ, Huang WY, Schoen RE, Giovannucci E, Chan AT, Chanock SJ, Peters U, Hunter DJ, Hayes RB. Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk. Hum Mol Genet. 2008 Sep 1; 17(17):2665-72.
    View in: PubMed
  22. Hazra A, Fuchs CS, Chan AT, Giovannucci EL, Hunter DJ. Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk. Cancer Causes Control. 2008 Nov; 19(9):975-80.
    View in: PubMed
  23. Kawasaki T, Nosho K, Ohnishi M, Suemoto Y, Glickman JN, Chan AT, Kirkner GJ, Mino-Kenudson M, Fuchs CS, Ogino S. Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. BMC Cancer. 2008; 8:33.
    View in: PubMed
  24. Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Wu K, Fuchs CS. Aspirin dose and duration of use and risk of colorectal cancer in men. Gastroenterology. 2008 Jan; 134(1):21-8.
    View in: PubMed
  25. Feskanich D, Bain C, Chan AT, Pandeya N, Speizer FE, Colditz GA. Aspirin and lung cancer risk in a cohort study of women: dosage, duration and latency. Br J Cancer. 2007 Nov 5; 97(9):1295-9.
    View in: PubMed
  26. Cho E, Willett WC, Colditz GA, Fuchs CS, Wu K, Chan AT, Zeisel SH, Giovannucci EL. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst. 2007 Aug 15; 99(16):1224-31.
    View in: PubMed
  27. Chan AT, Ogino S, Fuchs CS. Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med. 2007 May 24; 356(21):2131-42.
    View in: PubMed
  28. Chan AT. Can aspirin prevent colorectal cancer? Lancet. 2007 May 12; 369(9573):1577-8.
    View in: PubMed
  29. Chan AT, Manson JE, Feskanich D, Stampfer MJ, Colditz GA, Fuchs CS. Long-term aspirin use and mortality in women. Arch Intern Med. 2007 Mar 26; 167(6):562-72.
    View in: PubMed
  30. Chan AT. Non-steroidal Anti-Inflammatory Drugs: Role in Prevention of Colorectal Cancer. Up-to-Date. 2007.
  31. Chan JA, Meyerhardt JA, Chan AT, Giovannucci EL, Colditz GA, Fuchs CS. Hormone replacement therapy and survival after colorectal cancer diagnosis. J Clin Oncol. 2006 Dec 20; 24(36):5680-6.
    View in: PubMed
  32. Meyerhardt JA, Giovannucci EL, Holmes MD, Chan AT, Chan JA, Colditz GA, Fuchs CS. Physical activity and survival after colorectal cancer diagnosis. J Clin Oncol. 2006 Aug 1; 24(22):3527-34.
    View in: PubMed
  33. Hur C, Chan AT, Tramontano AC, Gazelle GS. Coxibs versus combination NSAID and PPI therapy for chronic pain: an exploration of the risks, benefits, and costs. Ann Pharmacother. 2006 Jun; 40(6):1052-63.
    View in: PubMed
  34. Michels KB, Giovannucci E, Chan AT, Singhania R, Fuchs CS, Willett WC. Fruit and vegetable consumption and colorectal adenomas in the Nurses' Health Study. Cancer Res. 2006 Apr 1; 66(7):3942-53.
    View in: PubMed
  35. Schernhammer ES, Tranah GJ, Giovannucci E, Chan AT, Ma J, Colditz GA, Hunter DJ, Willett WC, Fuchs CS. Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma. Br J Cancer. 2006 Mar 27; 94(6):928-34.
    View in: PubMed
  36. Chan AT, Manson JE, Albert CM, Chae CU, Rexrode KM, Curhan GC, Rimm EB, Willett WC, Fuchs CS. Nonsteroidal antiinflammatory drugs, acetaminophen, and the risk of cardiovascular events. Circulation. 2006 Mar 28; 113(12):1578-87.
    View in: PubMed
  37. Chan AT, Fuchs CS. Do cyclo-oxygenase 2 inhibitors increase the risk of cardiovascular events? Nat Clin Pract Oncol. 2005 Sep; 2(9):434-5.
    View in: PubMed
  38. Tranah GJ, Chan AT, Giovannucci E, Ma J, Fuchs C, Hunter DJ. Epoxide hydrolase and CYP2C9 polymorphisms, cigarette smoking, and risk of colorectal carcinoma in the Nurses' Health Study and the Physicians' Health Study. Mol Carcinog. 2005 Sep; 44(1):21-30.
    View in: PubMed
  39. Chan AT, Giovannucci EL, Meyerhardt JA, Schernhammer ES, Curhan GC, Fuchs CS. Long-term use of aspirin and nonsteroidal anti-inflammatory drugs and risk of colorectal cancer. JAMA. 2005 Aug 24; 294(8):914-23.
    View in: PubMed
  40. Chan AT, Tranah GJ, Giovannucci EL, Willett WC, Hunter DJ, Fuchs CS. Prospective study of N-acetyltransferase-2 genotypes, meat intake, smoking and risk of colorectal cancer. Int J Cancer. 2005 Jul 1; 115(4):648-52.
    View in: PubMed
  41. Chan AT, Ma J, Tranah GJ, Giovannucci EL, Rifai N, Hunter DJ, Fuchs CS. Hemochromatosis gene mutations, body iron stores, dietary iron, and risk of colorectal adenoma in women. J Natl Cancer Inst. 2005 Jun 15; 97(12):917-26.
    View in: PubMed
  42. Chan AT, Tranah GJ, Giovannucci EL, Hunter DJ, Fuchs CS. Genetic variants in the UGT1A6 enzyme, aspirin use, and the risk of colorectal adenoma. J Natl Cancer Inst. 2005 Mar 16; 97(6):457-60.
    View in: PubMed
  43. Chan AT, Tranah GJ, Giovannucci EL, Hunter DJ, Fuchs CS. A prospective study of genetic polymorphisms in the cytochrome P-450 2C9 enzyme and the risk for distal colorectal adenoma. Clin Gastroenterol Hepatol. 2004 Aug; 2(8):704-12.
    View in: PubMed
  44. Chan AT, Giovannucci EL, Schernhammer ES, Colditz GA, Hunter DJ, Willett WC, Fuchs CS. A prospective study of aspirin use and the risk for colorectal adenoma. Ann Intern Med. 2004 Feb 3; 140(3):157-66.
    View in: PubMed
  45. Schernhammer ES, Kang JH, Chan AT, Michaud DS, Skinner HG, Giovannucci E, Colditz GA, Fuchs CS. A prospective study of aspirin use and the risk of pancreatic cancer in women. J Natl Cancer Inst. 2004 Jan 7; 96(1):22-8.
    View in: PubMed
  46. Chan AT. Aspirin, non-steroidal anti-inflammatory drugs and colorectal neoplasia: future challenges in chemoprevention. Cancer Causes Control. 2003 Jun; 14(5):413-8.
    View in: PubMed
  47. Hylek EM, Regan S, Henault LE, Gardner M, Chan AT, Singer DE, Barry MJ. Challenges to the effective use of unfractionated heparin in the hospitalized management of acute thrombosis. Arch Intern Med. 2003 Mar 10; 163(5):621-7.
    View in: PubMed
  48. Chan AT. Aspirin, non-steroidal anti-inflammatory drugs, and colorectal neoplasia: future challenges in chemoprevention. Cancer Causes and Control. 2003; 14(5):413-18.
  49. Yee A, Brown J, Chan AT. Anticoagulation in primary care. Basch EM, Birnbaum SL, Garza C, Messersmith WA, editors. MGH Primer of Outpatient Medicine. 2002.
  50. Wong IH, Yeo W, Chan AT, Johnson PJ. Quantitative correlation of cytokeratin 19 mRNA level in peripheral blood with disease stage and metastasis in breast cancer patients: potential prognostic implications. Int J Oncol. 2001 Mar; 18(3):633-8.
    View in: PubMed
  51. Wong IH, Yeo W, Chan AT, Johnson PJ. Quantitative relationship of the circulating tumor burden assessed by reverse transcription-polymerase chain reaction for cytokeratin 19 mRNA in peripheral blood of colorectal cancer patients with Dukes' stage, serum carcinoembryonic antigen level and tumor progression. Cancer Lett. 2001 Jan 10; 162(1):65-73.
    View in: PubMed
  52. Wong IH, Chan AT, Johnson PJ. Molecular analysis of circulating tumor cells in peripheral blood from patients with germ cell tumor: a quantitative approach. Int J Mol Med. 2000 Oct; 6(4):491-4.
    View in: PubMed
  53. Wong IH, Chan AT, Johnson PJ. Quantitative analysis of circulating tumor cells in peripheral blood of osteosarcoma patients using osteoblast-specific messenger RNA markers: a pilot study. Clin Cancer Res. 2000 Jun; 6(6):2183-8.
    View in: PubMed
  54. Chan AT, Atiemo A, Diran LK, Licholai GP, McLaren Black P, Creager MA, Goldhaber SZ. Venous thromboembolism occurs frequently in patients undergoing brain tumor surgery despite prophylaxis. J Thromb Thrombolysis. 1999 Aug; 8(2):139-42.
    View in: PubMed
  55. Chan AT, Heller SJ, Van Dam J, Carr-Locke DL, Banks PA. Endoscopic cystgastrostomy: role of endoscopic ultrasonography. Am J Gastroenterol. 1996 Aug; 91(8):1622-5.
    View in: PubMed
  56. Su HC, Orange JS, Fast LD, Chan AT, Simpson SJ, Terhorst C, Biron CA. IL-2-dependent NK cell responses discovered in virus-infected beta 2-microglobulin-deficient mice. J Immunol. 1994 Dec 15; 153(12):5674-81.
    View in: PubMed
  57. McCorquodale MM, Burton BK, Arteaga G, Hauselman E, Chan AT. Partial monosomy 22q: A case report. Am J of Hum Genetics. 1992; 51(4):A293.
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